Background: Osteoarthritis is a chronic disease associated with pain, inflammation, stiffness and synovial effusion, with progressive functional limitation, compromising quality of life. It progressively leads to loss...Background: Osteoarthritis is a chronic disease associated with pain, inflammation, stiffness and synovial effusion, with progressive functional limitation, compromising quality of life. It progressively leads to loss or decrease in joint function. Pharmacological and non-pharmacological therapy seeks symptomatic management, complicated by a lack of adherence. After acetaminophen, non-steroidal anti-inflammatory drugs such as diclofenac are the most widely used medications. Objectives: The primary objective compared the analgesic effect of diclofenac 150 mg once daily vs. 50 mg three times daily in patients with knee osteoarthritis. The secondary objective assessed changes in quality of life. Method: One group received diclofenac 150 mg OD with placebo TTD. Another group received placebo OD and 50 mg active diclofenac (reference) TTD, both for 30 days. The evaluation of pain was carried out by a visual analog scale (VAS), at the beginning, 2, 3, 4, 15 and 30 days, quality of life (the WOMAC scale) and adverse effects, at 15 and 30 days. Results: Pain decreased significantly on days 15 and 30, compared to day 0, in both groups, without differences between groups. The total results in the WOMAC scale showed a very marked improvement at 15 and 30 days, without differences between groups. The most frequent adverse effects were constipation 6% in the reference group, and gastric discomfort 30.3% in the reference group vs 28.1%, in the Test group. Conclusions: Prolonged-release diclofenac 150 mg OD is as effective as diclofenac 50 mg TID for the treatment of patients with knee osteoarthritis.展开更多
目的:回顾性分析普通射频联合低温等离子射频消融术与膝关节腔内注射羧甲基壳多糖(医用几丁糖)治疗顽固性膝骨关节炎(knee osteoarthritis,KOA)的临床疗效和安全性。方法:纳入2020年2月至2021年3月中日友好医院疼痛科收治的顽固性KOA病...目的:回顾性分析普通射频联合低温等离子射频消融术与膝关节腔内注射羧甲基壳多糖(医用几丁糖)治疗顽固性膝骨关节炎(knee osteoarthritis,KOA)的临床疗效和安全性。方法:纳入2020年2月至2021年3月中日友好医院疼痛科收治的顽固性KOA病人66例,根据治疗方法不同分为手术组35例和注射组31例,分别在术前、术后第2周、1个月、3个月、6个月、12个月应用疼痛数字分级评分法(numerical rating scale,NRS)评分、西安大略和麦克马斯特大学(the Western Ontario and McMaster Universities,WOMAC)骨关节炎评分、药物使用率、手术相关并发症、病人的满意度进行随访评估以及统计学分析。结果:与术前相比,手术组疗效优于注射组,在术后2周、1个月、3个月、6个月、12个月手术组NRS评分和WOMAC评分、术后药物使用率均明显下降;两组术后均未观察到下肢麻木、下肢无力、感觉减退、感觉异常、神经痛等严重不良反应。术后12个月,手术组82.9%的病人对术后疗效满意,注射组38.7%的病人对术后疗效感到满意。结论:膝神经射频联合低温等离子射频消融术可以有效缓解膝关节疼痛,改善关节功能,且未发现严重不良反应,可以作为全膝关节置换术以外的顽固性KOA的替代治疗模式。展开更多
目的观察并比较火针和电针治疗肾虚髓亏型膝骨关节炎的临床疗效。方法将110例肾虚髓亏型膝骨关节炎患者随机分为两组,火针组56例,电针组54例。火针组采用毫针针刺和火针点刺治疗,电针组采用电针治疗。两组均隔日治疗1次,4星期为1个疗程...目的观察并比较火针和电针治疗肾虚髓亏型膝骨关节炎的临床疗效。方法将110例肾虚髓亏型膝骨关节炎患者随机分为两组,火针组56例,电针组54例。火针组采用毫针针刺和火针点刺治疗,电针组采用电针治疗。两组均隔日治疗1次,4星期为1个疗程,共治疗1个疗程。观察两组治疗前后视觉模拟评分(visual analogue scale,VAS)和西安大略和麦克马斯特大学骨关节炎指数(western Ontario and Mc Master universities osteoarthritis index,WOMAC)量表各项评分变化,并比较两组的临床疗效。结果两组治疗后VAS评分及WOMAC量表各项评分较同组治疗前均有显著性降低(P<0.01)。两组治疗后VAS评分和WOMAC量表各项评分比较,均无统计学差异(P>0.05)。两组治疗后4星期VAS评分和WOMAC量表各项评分均较治疗后进一步降低(P<0.01)。电针组治疗后8星期VAS评分和WOMAC量表疼痛、僵硬评分与治疗后4星期比较,差异有统计学意义(P<0.01),电针组治疗后8星期WOMAC量表疼痛、僵硬、关节功能评分与治疗后比较,差异有统计学意义(P<0.01);火针组治疗后8星期VAS评分和WOMAC量表疼痛、僵硬、关节功能评分与治疗后比较,差异有统计学意义(P<0.01)。火针组治疗后4星期VAS评分和WOMAC量表疼痛、僵硬及关节功能评分均明显低于电针组(P<0.05,P<0.01),治疗后8星期VAS评分和WOMAC量表疼痛、僵硬评分仍显著低于电针组(P<0.01)。火针组总有效率为94.6%,电针组为90.7%,两组比较差异无统计学意义(P>0.05)。结论毫针针刺和火针点刺与电针均能明显改善肾虚髓亏型膝骨关节炎疼痛、僵硬和关节功能,两者近期疗效相当,毫针针刺和火针点刺在远期疗效方面优于电针。展开更多
文摘Background: Osteoarthritis is a chronic disease associated with pain, inflammation, stiffness and synovial effusion, with progressive functional limitation, compromising quality of life. It progressively leads to loss or decrease in joint function. Pharmacological and non-pharmacological therapy seeks symptomatic management, complicated by a lack of adherence. After acetaminophen, non-steroidal anti-inflammatory drugs such as diclofenac are the most widely used medications. Objectives: The primary objective compared the analgesic effect of diclofenac 150 mg once daily vs. 50 mg three times daily in patients with knee osteoarthritis. The secondary objective assessed changes in quality of life. Method: One group received diclofenac 150 mg OD with placebo TTD. Another group received placebo OD and 50 mg active diclofenac (reference) TTD, both for 30 days. The evaluation of pain was carried out by a visual analog scale (VAS), at the beginning, 2, 3, 4, 15 and 30 days, quality of life (the WOMAC scale) and adverse effects, at 15 and 30 days. Results: Pain decreased significantly on days 15 and 30, compared to day 0, in both groups, without differences between groups. The total results in the WOMAC scale showed a very marked improvement at 15 and 30 days, without differences between groups. The most frequent adverse effects were constipation 6% in the reference group, and gastric discomfort 30.3% in the reference group vs 28.1%, in the Test group. Conclusions: Prolonged-release diclofenac 150 mg OD is as effective as diclofenac 50 mg TID for the treatment of patients with knee osteoarthritis.
文摘目的:回顾性分析普通射频联合低温等离子射频消融术与膝关节腔内注射羧甲基壳多糖(医用几丁糖)治疗顽固性膝骨关节炎(knee osteoarthritis,KOA)的临床疗效和安全性。方法:纳入2020年2月至2021年3月中日友好医院疼痛科收治的顽固性KOA病人66例,根据治疗方法不同分为手术组35例和注射组31例,分别在术前、术后第2周、1个月、3个月、6个月、12个月应用疼痛数字分级评分法(numerical rating scale,NRS)评分、西安大略和麦克马斯特大学(the Western Ontario and McMaster Universities,WOMAC)骨关节炎评分、药物使用率、手术相关并发症、病人的满意度进行随访评估以及统计学分析。结果:与术前相比,手术组疗效优于注射组,在术后2周、1个月、3个月、6个月、12个月手术组NRS评分和WOMAC评分、术后药物使用率均明显下降;两组术后均未观察到下肢麻木、下肢无力、感觉减退、感觉异常、神经痛等严重不良反应。术后12个月,手术组82.9%的病人对术后疗效满意,注射组38.7%的病人对术后疗效感到满意。结论:膝神经射频联合低温等离子射频消融术可以有效缓解膝关节疼痛,改善关节功能,且未发现严重不良反应,可以作为全膝关节置换术以外的顽固性KOA的替代治疗模式。
文摘目的观察并比较火针和电针治疗肾虚髓亏型膝骨关节炎的临床疗效。方法将110例肾虚髓亏型膝骨关节炎患者随机分为两组,火针组56例,电针组54例。火针组采用毫针针刺和火针点刺治疗,电针组采用电针治疗。两组均隔日治疗1次,4星期为1个疗程,共治疗1个疗程。观察两组治疗前后视觉模拟评分(visual analogue scale,VAS)和西安大略和麦克马斯特大学骨关节炎指数(western Ontario and Mc Master universities osteoarthritis index,WOMAC)量表各项评分变化,并比较两组的临床疗效。结果两组治疗后VAS评分及WOMAC量表各项评分较同组治疗前均有显著性降低(P<0.01)。两组治疗后VAS评分和WOMAC量表各项评分比较,均无统计学差异(P>0.05)。两组治疗后4星期VAS评分和WOMAC量表各项评分均较治疗后进一步降低(P<0.01)。电针组治疗后8星期VAS评分和WOMAC量表疼痛、僵硬评分与治疗后4星期比较,差异有统计学意义(P<0.01),电针组治疗后8星期WOMAC量表疼痛、僵硬、关节功能评分与治疗后比较,差异有统计学意义(P<0.01);火针组治疗后8星期VAS评分和WOMAC量表疼痛、僵硬、关节功能评分与治疗后比较,差异有统计学意义(P<0.01)。火针组治疗后4星期VAS评分和WOMAC量表疼痛、僵硬及关节功能评分均明显低于电针组(P<0.05,P<0.01),治疗后8星期VAS评分和WOMAC量表疼痛、僵硬评分仍显著低于电针组(P<0.01)。火针组总有效率为94.6%,电针组为90.7%,两组比较差异无统计学意义(P>0.05)。结论毫针针刺和火针点刺与电针均能明显改善肾虚髓亏型膝骨关节炎疼痛、僵硬和关节功能,两者近期疗效相当,毫针针刺和火针点刺在远期疗效方面优于电针。
