[Objectives]To optimize the extraction process of polysaccharide in Embelia parviflora Wall.by response surface methodology,and to study the antioxidant activity in vitro of polysaccharide in E.parviflora,so as to pro...[Objectives]To optimize the extraction process of polysaccharide in Embelia parviflora Wall.by response surface methodology,and to study the antioxidant activity in vitro of polysaccharide in E.parviflora,so as to provide a basis for the further development and utilization of E.parviflora.[Methods]The solid-to-liquid ratio,extraction temperature,extraction time and extraction times were used as single factors to investigate the effects.On this basis,the response surface methodology(RSM)was used to optimize the extraction process of polysaccharide in E.parviflora.DPPH and ABTS free radicals were used to investigate the antioxidant capacity of polysaccharide in E.parviflora.[Results]The optimal solid-to-liquid ratio for extraction of polysaccharide from E.parviflora was 32∶1(mL/g),extraction temperature was 77℃,and extraction time was 36 min.The IC50 values of DPPH and ABTS were 0.04 and 0.03 mg/mL,respectively.[Conclusions]The optimized extraction process of polysaccharide in E.parviflora is stable,the extraction rate is high,and has strong antioxidant activity.It is expected to provide a reference for the industrial extraction of polysaccharide from E.parviflora.展开更多
[Objectives] To establish the HPLC fingerprint of Spilanthes paniculata Wall. ex DC. and provide reference for the quality control of medicinal materials. [Methods]Welch Ultimate XB-C18( 5 μm,250 mm ×4. 6 mm) ch...[Objectives] To establish the HPLC fingerprint of Spilanthes paniculata Wall. ex DC. and provide reference for the quality control of medicinal materials. [Methods]Welch Ultimate XB-C18( 5 μm,250 mm ×4. 6 mm) chromatographic column was adopted,and the mobile phase was acetonitrile-0. 1% phosphoric acid aqueous solution for gradient elution,the detection wavelength was 328 nm,the column temperature was 25 ℃,the similarities of 18 different batches of medicinal materials were evaluated,and the HPLC fingerprint chromatogram of S. paniculata Wall. ex DC. was set up. [Results] The RSDs of precision,repeatability and stability of HPLC fingerprint of 18 batches of S. paniculata Wall. ex DC. medicine materials were all less than 3%;HPLC reference fingerprint of the medicine materials was established.[Conclusions]HPLC fingerprint was established,its data were stable and reliable,and the method was simple and efficient,which could provide reference for the quality evaluation of Zhuang medicine S. paniculata Wall. ex DC.展开更多
[Objectives]To optimize the ultrasonic-assisted extraction process of polysaccharides from Cyathula Capitata( Wall.) Moq. and evaluate its antioxidant capacity in vitro. [Methods] The single factor orthogonal design w...[Objectives]To optimize the ultrasonic-assisted extraction process of polysaccharides from Cyathula Capitata( Wall.) Moq. and evaluate its antioxidant capacity in vitro. [Methods] The single factor orthogonal design was applied to explore the effects of ultrasonic time,solid-to-liquid ratio,extraction time and ethanol precipitation concentration on the extraction rate of crude polysaccharides from C. Capitata,to obtain the optimal extraction process; DPPH and ABTS^+ free radical scavenging ability was detected to evaluate its in vitro antioxidant activity.[Results]The optimal extraction process of C. Capitata crude polysaccharide was as follows: solid-to-liquid ratio was 40∶ 1,the extraction temperature was 50℃,the ultrasonic time was 80 min. Under such conditions,the extraction rate of C. Capitata crude polysaccharide was 10. 51%,and the purity was 56. 9%; C. Capitata crude polysaccharide has good scavenging ability to DPPH and ABTS^+ free radicals,and its IC_(50) values are 0. 468 and 0. 231 mg/mL,respectively. [Conclusions]The optimized process is simple and feasible,and the C. Capitata polysaccharide has good antioxidant activity in vitro. This experiment provides a basis for the further development and utilization of the C. Capitata polysaccharide.展开更多
Delphinium denudatum Wall.is one of the important medicinal herbs of traditional Persian medicine and is known as Jadwar.Medicinal plants are the most widely used drugs in traditional Persian medicine and has been use...Delphinium denudatum Wall.is one of the important medicinal herbs of traditional Persian medicine and is known as Jadwar.Medicinal plants are the most widely used drugs in traditional Persian medicine and has been used for various diseases since earlier times.The medicinal uses of Delphinium denudatum Wall.date back to over 1,000 years ago.Rhazes(845–925 C.E.)was the first Persian physician and scientist who reported the use of Delphinium denudatum Wall.as a herbal remedy.During the following centuries,the usages of Delphinium denudatum Wall.in the treatment of various diseases has been mentioned in the books and references of traditional Persian medicine for cures to various diseases such as neurologic and psychiatric disease,gastrointestinal disease,fever,pain,and poisoning.According to modern studies,the dried roots of Delphinium denudatum Wall.have antipyretic,antimicrobial,anticonvulsant,hepatoprotective,antioxidant,and pain-relieving properties.Biomolecules from roots of Delphinium denudatum Wall.were also identified as potential cures for central nervous system diseases as well as for the amelioration of morphine addiction.Delphinium denudatum Wall.,with its properties involving the prevention of mitochondrial dysfunction,reduction of oxidative stress,and inflammation and immune dysregulation,can be utilized in curing inflammatory disorders.The effective therapeutic influence of root extract of Delphinium denudatum Wall.against several diseases needs to be confirmed through controlled clinical trials.This article reviews the different features of Delphinium denudatum Wall.and focuses on the well-known therapeutic effects of this herbal drug on various human disorders and animal disease models.展开更多
[Objectives]To study the chemical constituents of the fruit of Embelia undulata(Wall.)Mez.[Methods]Silica gel column chromatography,gel column chromatography,recrystallization,high-performance preparative liquid chrom...[Objectives]To study the chemical constituents of the fruit of Embelia undulata(Wall.)Mez.[Methods]Silica gel column chromatography,gel column chromatography,recrystallization,high-performance preparative liquid chromatography and other modern separation methods and techniques were used to separate and purify the chemical components of the ethyl acetate fraction of the fruit of E.undulata(Wall.)Mez,and based on the physical and chemical properties and spectral data,their structure was identified.[Results]Six compounds were isolated from the fruit of E.undulata(Wall.)Mez,including trimethyl citrate(1),vanillic acid(2),5-hydroxymethylfurfural(3),1,5-dimethyl citrate(4),1,6-dimethyl-5-ethyl citrate(5)and 3,4-dihydroxybenzoic acid(6).[Conclusions]Compounds 1-6 are all isolated from E.undulata(Wall.)Mez for the first time.展开更多
Panax pseudoginseng Wall., a highly medicinal, herbaceous, long-lived plant, grows in the forest litter of shady primary forest. The species is threatened in the natural habitat due to unsustainable harvesting of rhiz...Panax pseudoginseng Wall., a highly medicinal, herbaceous, long-lived plant, grows in the forest litter of shady primary forest. The species is threatened in the natural habitat due to unsustainable harvesting of rhizome for medicine and habitat destruction. The species has very poor adaptive power to the synthetic environment and fails to grow and propagate. Present study was undertaken to develop suitable low cost propagation technique and produce clonal planting materials through rhizome splitting and root cutting. Rhizomes and roots were cut into segments and sowed in the raised soil bed prepared by mixing decayed wood powder, sand and top black soil at 1:1:3 ratios in a shaded poly house. Of the sowed rhizome segments ~55% segments remained recalcitrant to morphogenetic response in the first year of the study and the response improved in the subsequent years. In the third year ~51% rhizome segments responded positively. The horizontal root cuts mostly remained morphogenetically dormant but inclined root cuts exhibited better response. The morphogenetic response from the roots was comparatively very poor compare to rhizome segments. The plantlets formed both rhizome segments and root cuttings were maintained for three years in the bed/pots followed by transferring in the cultivated plots.展开更多
Biological characteristics of Alternaria tenuissima on Dendrobium sandidium Wall. et Lindl. were studied. The result showed that A. tenuissima on D.sandidium Wall. et Lindl. could grow at temperature 5- 35 ℃ and p H ...Biological characteristics of Alternaria tenuissima on Dendrobium sandidium Wall. et Lindl. were studied. The result showed that A. tenuissima on D.sandidium Wall. et Lindl. could grow at temperature 5- 35 ℃ and p H value of 2- 10,the optimal temperature and p H value were 25℃ and 7 for its growth and sporulation,respectively. Starch was the optimal carbon sources and peptone was the optimal nitrogen source for the growth and sporulation of bacterial colony,respectively; PSA and PCA were the optimal media for its growth and sporulation,respectively.展开更多
Prototype experiments were carried out on the explosion-proof performance of the RC blast wall.The mass of TNT detonated in the experiments is 5 kg and 20 kg respectively.The shock wave overpressure was tested in diff...Prototype experiments were carried out on the explosion-proof performance of the RC blast wall.The mass of TNT detonated in the experiments is 5 kg and 20 kg respectively.The shock wave overpressure was tested in different regions.The above experiments were numerically simulated,and the simulated shock wave overpressure waveforms were compared with that tested and given by CONWEP program.The results show that the numerically simulated waveform is slightly different from the test waveform,but similar to CONWEP waveform.Through dimensional analysis and numerical simulation under different working conditions,the equation for the attenuation rate of the diffraction overpressure behind the blast wall was obtained.According to the corresponding standards,the degree of casualties and the damage degree of the brick concrete building at a certain distance behind the wall can be determined when parameters are set.The above results can provide a reference for the design and construction of the reinforced concrete blast wall.展开更多
Frame and rocking wall(FRW)structures have excellent resilient performance during earthquakes.However,the concrete at interfacial corners of rocking walls(RWs)is easily crushed due to local extreme compression during ...Frame and rocking wall(FRW)structures have excellent resilient performance during earthquakes.However,the concrete at interfacial corners of rocking walls(RWs)is easily crushed due to local extreme compression during the rocking process.An innovative RW with a curved interface is proposed to prevent interfacial corners from producing local damage,enhancing its earthquake resilient performance(ERP).The precast wall panel with a curved interface is assembled into an integral self-centering hybrid rocking wall(SCRW)by two post-tensioned unbonded prestressed tendons.Moreover,two ordinary energy dissipation steel rebars and two shear reinforcements are arranged to increase the energy dissipation capacity and lateral resistance.Two SCRW specimens and one monolithic reinforced concrete(RC)shear wall(SW)were tested under pseudo-static loading to compare the ERPs of the proposed SCRW and the SW,focusing on studying the effect of the curved interface on the SCRW.The key resilient performance of rocking effects,failure modes,and hysteretic properties of the SCRW were explored.The results show that nonlinear deformations of the SCRW are concentrated along the interface between the SCRW and the foundation,avoiding damage within the SCRW.The restoring force provided by the prestressed tendons can effectively realize self-centering capacity with small residual deformation,and the resilient performance of the SCRW is better than that of monolithic SW.In addition,the curved interface of the SCRW makes the rocking center change and move inward,partially relieving the stress concentration and crush of concrete.The rocking range of the rocking center is about 41.4%of the width of the SCRW.展开更多
H-steel all-bolted connection steel frame structures with heat preservation and decoration composite wall boards were investigated and the seismic performances of three scaled specimens were studied.The failure modes,...H-steel all-bolted connection steel frame structures with heat preservation and decoration composite wall boards were investigated and the seismic performances of three scaled specimens were studied.The failure modes,hysteresis curves,bearing capacity,ductility,energy dissipation capacity,stiffness degradation and strain distribution were discussed.The calculation method of structural theoretical internal force was presented.The results showed that the overall structural seismic performance was better,and the structural ductility met the demands of elastic-plastic inter-story drift angle for seismic design.The H-steel weak-axis connection structure obtained better energy dissipation capacity,and its bearing capacity and stiffness were slightly different from the strong-axis connection.The heat preservation and decoration performance of composite wallboard and the all-bolted connection of the steel frame realized prefabrication during the whole construction period.The plastic hinge of the steel beam can be moved outwards because of the L-angles,which effectively avoids stress concentration in joint areas and expands the plastic hinge range.The errors between the theoretical structural capacity calculated by the plastic analysis method and the test results were within 2.44%.In addition,structural failure mechanisms and bearing capacities were verified by the finite element(FE)analysis,and the effects of the main parameters on the structures were investigated.The FE verification results were the same as in the test.The research results provide theoretical support and technical guidance for the application of thermal insulation and decorative composite wall panels in H-shaped steel all-bolted steel frames.展开更多
Combining the detached eddy simulation(DES)method and Ffowcs Williams-Hawkings(FW-H)equation,the effect of bogie cavity end wall inclination on the flow field and aerodynamic noise in the bogie region is numerically s...Combining the detached eddy simulation(DES)method and Ffowcs Williams-Hawkings(FW-H)equation,the effect of bogie cavity end wall inclination on the flow field and aerodynamic noise in the bogie region is numerically studied.First,the simulation is conducted based on a simplified cavity-bogie model,including five cases with different inclination angles of the front and rear walls of the cavity.By comparing and analyzing the flow field and acoustic results of the five cases,the influence of the regularity and mechanism of the bogie cavity end wall inclination on the flow field and the aerodynamic noise of the bogie region are revealed.Then,the noise reduction strategy determined by the results of the simplified cavity-bogie model is applied to a three-car marshaling train model to verify its effectiveness when applied to the real train.The results reveal that the forward inclination of the cavity front wall enlarges the influence area of shear vortex structures formed at the leading edge of the cavity and intensifies the interaction between the vortex structures and the front wheelset,frontmotor,and front gearbox,resulting in the increase of the aerodynamic noise generated by the bogie itself.The backward inclination of the cavity rear wall is conducive to guiding the vortex structures flow out of the cavity and weakening the interaction between the shear vortex structures and the cavity rear wall,leading to the reduction of the aerodynamic noise generated by the bogie cavity.Inclining the rear end wall of the foremost bogie cavity of the head car is a feasible aerodynamic noise reduction measure for high-speed trains.展开更多
The nutrient digestion,absorption and biological activity of bee pollen may be limited due to the complex pollen wall.Here,the effect of superfine grinding technology on the release of nutrients from bee pollen were i...The nutrient digestion,absorption and biological activity of bee pollen may be limited due to the complex pollen wall.Here,the effect of superfine grinding technology on the release of nutrients from bee pollen were investigated,and their antioxidant activities and in vitro digestion were explored in this study.Results showed that the content of nutrients in bee pollen increased after wall disruption.Among them,fat content increased by 22.55%-8.31%,protein content increased by 0.54%-4.91%,starch content increased by 36.31%-48.64%,soluble sugar content increased by 20.57%-29.67%,total phenolic acid content increased by 11.73%-86.98%and total flavonoids content increased by 14.29%-24.79%.At the same time,the antioxidant activity increased by 14.84%-46.00%.Furthermore,the active components such as phenolic compounds in the wall-disruption bee pollen were more readily to be released during the in vitro digestion,and easier to be absorbed because of their higher bioaccessibility.Antioxidant activities during in vitro digestion were also improved in walldisruption bee pollen.These findings provide evidence that bee pollen wall disruption was suggested,thus,it is more conducive to exerting the value of bee pollen in functional foods.展开更多
To date,few models are available in the literature to consider the creep behavior of geosynthetics when predicting the lateral deformation(d)of geosynthetics-reinforced soil(GRS)retaining walls.In this study,a general...To date,few models are available in the literature to consider the creep behavior of geosynthetics when predicting the lateral deformation(d)of geosynthetics-reinforced soil(GRS)retaining walls.In this study,a general hyperbolic creep model was first introduced to describe the long-term deformation of geosynthetics,which is a function of elapsed time and two empirical parameters a and b.The conventional creep tests with three different tensile loads(Pr)were conducted on two uniaxial geogrids to determine their creep behavior,as well as the a-Pr and b-Pr relationships.The test results show that increasing Pr accelerates the development of creep deformation for both geogrids.Meanwhile,a and b respectively show exponential and negatively linear relationships with Pr,which were confirmed by abundant experimental data available in other studies.Based on the above creep model and relationships,an accurate and reliable analytical model was then proposed for predicting the time-dependent d of GRS walls with modular block facing,which was further validated using a relevant numerical investigation from the previous literature.Performance evaluation and comparison of the proposed model with six available prediction models were performed.Then a parametric study was carried out to evaluate the effects of wall height,vertical spacing of geogrids,unit weight and internal friction angle of backfills,and factor of safety against pullout on d at the end of construction and 5 years afterwards.The findings show that the creep effect not only promotes d but also raises the elevation of the maximum d along the wall height.Finally,the limitations and application prospects of the proposed model were discussed and analyzed.展开更多
The present work aims to assess earthquake-induced earth-retaining(ER)wall displacement.This study is on the dynamics analysis of various earth-retaining wall designs in hollow precast concrete panels,reinforcement co...The present work aims to assess earthquake-induced earth-retaining(ER)wall displacement.This study is on the dynamics analysis of various earth-retaining wall designs in hollow precast concrete panels,reinforcement concrete facing panels,and gravity-type earth-retaining walls.The finite element(FE)simulations utilized a 3D plane strain condition to model full-scale ER walls and numerous nonlinear dynamics analyses.The seismic performance of differentmodels,which includes reinforcement concrete panels and gravity-type and hollowprecast concrete ER walls,was simulated and examined using the FE approach.It also displays comparative studies such as stress distribution,deflection of the wall,acceleration across the wall height,lateral wall displacement,lateral wall pressure,and backfill plastic strain.Three components of the created ER walls were found throughout this research procedure.One is a granular reinforcement backfill,while the other is a wall-facing panel and base foundation.The dynamic response effects of varied earth-retaining walls have also been studied.It was discovered that the facing panel of the model significantly impacts the earthquake-induced displacement of ER walls.The proposed analytical model’s validity has been evaluated and compared with the reinforcement concrete facing panels,gravity-type ER wall,scientifically available data,and American Association of State Highway and Transportation Officials(AASHTO)guidelines results based on FE simulation.The results of the observations indicate that the hollow prefabricated concrete ER wall is the most feasible option due to its lower displacement and high-stress distribution compared to the two types.The methodology and results of this study establish standards for future analogous investigations and professionals,particularly in light of the increasing computational capabilities of desktop computers.展开更多
The impact sensitivity assessment of spacecraft is to obtain the probability of spacecraft encountering the OD/M(orbital debris or meteoroid),which is a prerequisite for survivability assessment of on-orbit spacecraft...The impact sensitivity assessment of spacecraft is to obtain the probability of spacecraft encountering the OD/M(orbital debris or meteoroid),which is a prerequisite for survivability assessment of on-orbit spacecraft.An impact sensitivity assessment method of spacecraft based on virtual exterior wall was proposed to improve the computational efficiency.This method eliminates determination of the outermost surface elements of the spacecraft before generating the debris rays,which are assumed to originate from a non-concave virtual wall that completely wraps the spacecraft.The Dist Mesh method was adopted for the generating of the virtual wall to ensure its mesh quality.The influences of the sizes,mesh densities,shapes of the virtual wall on the efficiency and accuracy were considered to obtain the best combination of the size and mesh density of the wall and spacecraft.The results of this method were compared with those of S3DE(Survivability of Spacecraft in Space Debris Environment),BUMPER,MDPANTO,ESABASE2/Debris to verify the feasibility of the method.The PCHIP(Piecewise Cubic Hermite Interpolating Polynomial)was used to fit the size vs.flux relationship of the space debris to acquire the impact probability of OD/M with arbitrary size on the spacecraft.展开更多
Rock avalanches are generally difficult to prevent and control due to their high velocities and the extensive destruction they cause.However,barrier structures constructed along the path of a rock avalanche can partia...Rock avalanches are generally difficult to prevent and control due to their high velocities and the extensive destruction they cause.However,barrier structures constructed along the path of a rock avalanche can partially mitigate the magnitudes and consequences of such catastrophic events.We selected a rock avalanche in Nayong County,Guizhou Province,China as a case to study the effect of the location and height of a retaining wall on the dynamic characteristics of rock avalanche by using both actual terrain-based laboratory-model tests and coupled PFC3D-FLAC3D numerical simulations.Our findings demonstrate that a retaining wall can largely block a rock avalanche and its protective efficacy is significantly influenced by the integrity of the retaining wall.Coupled numerical simulation can serve as a powerful tool for analyzing the interaction between a rock avalanche and a retaining wall,facilitating precise observations of its deformation and destruction.The impact-curve characteristics of the retaining wall depend upon whether or not the rock avalanche-induced destruction is taken into account.The location of the retaining wall exerts a greater influence on the outcome compared to the height and materials of the retaining wall,while implementing a stepped retaining-wall pattern in accordance with the terrain demonstrates optimal efficacy in controlling rock avalanche.展开更多
BACKGROUND Malignant triton tumors(MTTs)comprise a subgroup of malignant peripheral nerve sheath tumors(MPNSTs)that exhibits rhabdomyosarcomatous differen-tiation and follow an aggressive course.MTTs are primarily loc...BACKGROUND Malignant triton tumors(MTTs)comprise a subgroup of malignant peripheral nerve sheath tumors(MPNSTs)that exhibits rhabdomyosarcomatous differen-tiation and follow an aggressive course.MTTs are primarily located along peripheral nerves.Cases of MTTs in the abdominal wall have not been reported.MTT has a poorer prognosis than classic MPNSTs,and accurate diagnosis necessitates a keen understanding of the clinical history and knowledge of its differential diagnosis intricacies.Treatment for MTTs mirrors that for MPNSTs and is predominantly surgical.CASE SUMMARY A 49-year-old woman presented with a subcutaneous mass in her lower abdo-minal wall and a pre-existing surgical scar that had grown slowly over 3-4 months before the consultation.She had previously undergone radical hysterectomy and concurrent chemo-radiotherapy for cervical cancer approximately 5 years prior to the consultation.Abdominal computed tomography(CT)showed a 1.3 cm midline mass in the lower abdomen with infiltration into the rectus abdominis muscle.There was no sign of metastasis(T1N0M0).An incisional biopsy identified sporadic MTT of the lower abdomen.A comprehensive surgical excision with a 3 cm margin inclusive of the peritoneum was executed.Subse-quently,the general surgeon utilized an approach akin to the open peritoneal onlay mesh technique.The patient underwent additional treatment with an excision shaped as a mini-abdominoplasty for the skin defect.No complications arose,and annual follow-up CTs did not show signs of recurrence or metastasis.CONCLUSION An abdominal MTT was efficaciously treated with extensive excision and abdominal wall reconstruction,eliminating the need for postoperative radiotherapy.展开更多
BACKGROUND Intracranial atherosclerosis,a leading cause of stroke,involves arterial plaque formation.This study explores the link between plaque remodelling patterns and diabetes using high-resolution vessel wall imag...BACKGROUND Intracranial atherosclerosis,a leading cause of stroke,involves arterial plaque formation.This study explores the link between plaque remodelling patterns and diabetes using high-resolution vessel wall imaging(HR-VWI).AIM To investigate the factors of intracranial atherosclerotic remodelling patterns and the relationship between intracranial atherosclerotic remodelling and diabetes mellitus using HR-VWI.METHODS Ninety-four patients diagnosed with middle cerebral artery or basilar artery INTRODUCTION Intracranial atherosclerotic disease is one of the main causes of ischaemic stroke in the world,accounting for approx-imately 10%of transient ischaemic attacks and 30%-50%of ischaemic strokes[1].It is the most common factor among Asian people[2].The adaptive changes in the structure and function of blood vessels that can adapt to changes in the internal and external environment are called vascular remodelling,which is a common and important pathological mechanism in atherosclerotic diseases,and the remodelling mode of atherosclerotic plaques is closely related to the occurrence of stroke.Positive remodelling(PR)is an outwards compensatory remodelling where the arterial wall grows outwards in an attempt to maintain a constant lumen diameter.For a long time,it was believed that the degree of stenosis can accurately reflect the risk of ischaemic stroke[3-5].Previous studies have revealed that lesions without significant luminal stenosis can also lead to acute events[6,7],as summarized in a recent meta-analysis study in which approximately 50%of acute/subacute ischaemic events were due to this type of lesion[6].Research[8,9]has pointed out that the PR of plaques is more dangerous and more likely to cause acute ischaemic stroke.Previous studies[10-13]have found that there are specific vascular remodelling phenomena in the coronary and carotid arteries of diabetic patients.However,due to the deep location and small lumen of intracranial arteries and limitations of imaging techniques,the relationship between intracranial arterial remodelling and diabetes is still unclear.In recent years,with the development of magnetic resonance technology and the emergence of high-resolution(HR)vascular wall imaging,a clear and multidimensional display of the intracranial vascular wall has been achieved.Therefore,in this study,HR wall imaging(HR-VWI)was used to display the remodelling characteristics of bilateral middle cerebral arteries and basilar arteries and to explore the factors of intracranial vascular remodelling and its relationship with diabetes.展开更多
BACKGROUND Gastric wall necrosis is a rare complication of endoscopic treatment for bleeding gastric ulcer,which may exacerbate the patient’s condition once it occurs and may even require surgical intervention for tr...BACKGROUND Gastric wall necrosis is a rare complication of endoscopic treatment for bleeding gastric ulcer,which may exacerbate the patient’s condition once it occurs and may even require surgical intervention for treatment.CASE SUMMARY A 59-year-old man was admitted to our department with melena.Endoscopy revealed a giant ulcer in the gastric antrum with a visible vessel in its center,which was treated with sclerosants and tissue glue injection and resulted in necrosis of the gastric wall.CONCLUSION Injection of sclerosants and tissue glue may lead to gastric wall necrosis,which is a serious complication.Therefore,before administering this treatment to patients,we should consider other more effective methods of hemostasis to avoid gastric wall necrosis.展开更多
BACKGROUND Hepatic cystic and alveolar echinococcosis coinfections,particularly with concurrent abscesses and sinus tract formation,are extremely rare.This article presents a case of a patient diagnosed with this uniq...BACKGROUND Hepatic cystic and alveolar echinococcosis coinfections,particularly with concurrent abscesses and sinus tract formation,are extremely rare.This article presents a case of a patient diagnosed with this unique presentation,discussing the typical imaging manifestations of both echinococcosis types and detailing the diagnosis and surgical treatment experience thereof.CASE SUMMARY A 39-year-old Tibetan woman presented with concurrent hepatic cystic and alveolar echinococcosis,accompanied by abdominal wall abscesses and sinus tract formation.Initial conventional imaging examinations suggested only hepatic cystic echinococcosis,but intraoperative and postoperative pathological examination revealed the coinfection.Following radical resection of the lesions,the patient’s condition improved,and she was discharged soon thereafter.Subsequent outpatient follow-ups confirmed no recurrence of the hydatid lesion and normal surgical wound healing.Though mixed hepatic cystic and alveolar echinococcosis with abdominal wall abscesses and sinus tract formations are rare,the general treatment approach remains consistent with that of simpler infections of alveolar echinococcosis.CONCLUSION Lesions involving the abdominal wall and sinus tract formation,may require radical resection.Long-term prognosis includes albendazole and follow-up examinations.展开更多
基金National Natural Science Foundation of China(81660701)Natural Science Foundation of Guangxi(2016GXNSFAA380148)+1 种基金Scientific Research Innovation Program of Guangxi University of Chinese Medicine(YJSZ201712)Program of Key Laboratory for Purification and Quality Analysis of TCM Extraction in Guangxi Universities(Gui Jiao Ke Yan[2014]No.6).
文摘[Objectives]To optimize the extraction process of polysaccharide in Embelia parviflora Wall.by response surface methodology,and to study the antioxidant activity in vitro of polysaccharide in E.parviflora,so as to provide a basis for the further development and utilization of E.parviflora.[Methods]The solid-to-liquid ratio,extraction temperature,extraction time and extraction times were used as single factors to investigate the effects.On this basis,the response surface methodology(RSM)was used to optimize the extraction process of polysaccharide in E.parviflora.DPPH and ABTS free radicals were used to investigate the antioxidant capacity of polysaccharide in E.parviflora.[Results]The optimal solid-to-liquid ratio for extraction of polysaccharide from E.parviflora was 32∶1(mL/g),extraction temperature was 77℃,and extraction time was 36 min.The IC50 values of DPPH and ABTS were 0.04 and 0.03 mg/mL,respectively.[Conclusions]The optimized extraction process of polysaccharide in E.parviflora is stable,the extraction rate is high,and has strong antioxidant activity.It is expected to provide a reference for the industrial extraction of polysaccharide from E.parviflora.
基金Supported by"Collaborative Innovation Center in Guangxi in 2011-Study on Fingerprint of Three Kinds of Zhuang Medicine:Gynura crepidioides Benth.,Spilanthes paniculata Wall. ex DC.Lindernia ruellioides(Colsm)Pennell.,Program of Guangxi Scientific Research and Technology Development(Gui Ke Chong 1598005-10)+3 种基金Zhuang Yao Medicine Collaborative Innovation Center(No.20,Gui Jiao Ke Yan[2013])Guangxi Zhuang Yao Medicine Key Laboratory(No.32,Gui Ke Ji Zi[2014])Guangxi Zhuang Pharmacy Key Discipline(No.16,Gui Jiao Ke Yan[2013])Research on the Innovation Theory and Pharmacodynamics of Traditional Chinese Medicine by Guangxi Bagui Scholars(J13162)
文摘[Objectives] To establish the HPLC fingerprint of Spilanthes paniculata Wall. ex DC. and provide reference for the quality control of medicinal materials. [Methods]Welch Ultimate XB-C18( 5 μm,250 mm ×4. 6 mm) chromatographic column was adopted,and the mobile phase was acetonitrile-0. 1% phosphoric acid aqueous solution for gradient elution,the detection wavelength was 328 nm,the column temperature was 25 ℃,the similarities of 18 different batches of medicinal materials were evaluated,and the HPLC fingerprint chromatogram of S. paniculata Wall. ex DC. was set up. [Results] The RSDs of precision,repeatability and stability of HPLC fingerprint of 18 batches of S. paniculata Wall. ex DC. medicine materials were all less than 3%;HPLC reference fingerprint of the medicine materials was established.[Conclusions]HPLC fingerprint was established,its data were stable and reliable,and the method was simple and efficient,which could provide reference for the quality evaluation of Zhuang medicine S. paniculata Wall. ex DC.
基金Supported by Open Fund Project of Key Laboratory of Higher Education in Sichuan Province in 2017 for Development of Characteristic Biological Resources in Dry and Hot Valley(GR-2017-C-01)
文摘[Objectives]To optimize the ultrasonic-assisted extraction process of polysaccharides from Cyathula Capitata( Wall.) Moq. and evaluate its antioxidant capacity in vitro. [Methods] The single factor orthogonal design was applied to explore the effects of ultrasonic time,solid-to-liquid ratio,extraction time and ethanol precipitation concentration on the extraction rate of crude polysaccharides from C. Capitata,to obtain the optimal extraction process; DPPH and ABTS^+ free radical scavenging ability was detected to evaluate its in vitro antioxidant activity.[Results]The optimal extraction process of C. Capitata crude polysaccharide was as follows: solid-to-liquid ratio was 40∶ 1,the extraction temperature was 50℃,the ultrasonic time was 80 min. Under such conditions,the extraction rate of C. Capitata crude polysaccharide was 10. 51%,and the purity was 56. 9%; C. Capitata crude polysaccharide has good scavenging ability to DPPH and ABTS^+ free radicals,and its IC_(50) values are 0. 468 and 0. 231 mg/mL,respectively. [Conclusions]The optimized process is simple and feasible,and the C. Capitata polysaccharide has good antioxidant activity in vitro. This experiment provides a basis for the further development and utilization of the C. Capitata polysaccharide.
文摘Delphinium denudatum Wall.is one of the important medicinal herbs of traditional Persian medicine and is known as Jadwar.Medicinal plants are the most widely used drugs in traditional Persian medicine and has been used for various diseases since earlier times.The medicinal uses of Delphinium denudatum Wall.date back to over 1,000 years ago.Rhazes(845–925 C.E.)was the first Persian physician and scientist who reported the use of Delphinium denudatum Wall.as a herbal remedy.During the following centuries,the usages of Delphinium denudatum Wall.in the treatment of various diseases has been mentioned in the books and references of traditional Persian medicine for cures to various diseases such as neurologic and psychiatric disease,gastrointestinal disease,fever,pain,and poisoning.According to modern studies,the dried roots of Delphinium denudatum Wall.have antipyretic,antimicrobial,anticonvulsant,hepatoprotective,antioxidant,and pain-relieving properties.Biomolecules from roots of Delphinium denudatum Wall.were also identified as potential cures for central nervous system diseases as well as for the amelioration of morphine addiction.Delphinium denudatum Wall.,with its properties involving the prevention of mitochondrial dysfunction,reduction of oxidative stress,and inflammation and immune dysregulation,can be utilized in curing inflammatory disorders.The effective therapeutic influence of root extract of Delphinium denudatum Wall.against several diseases needs to be confirmed through controlled clinical trials.This article reviews the different features of Delphinium denudatum Wall.and focuses on the well-known therapeutic effects of this herbal drug on various human disorders and animal disease models.
基金Independent Research Project of Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards(Gui Zhong Zhong Zi 201503).
文摘[Objectives]To study the chemical constituents of the fruit of Embelia undulata(Wall.)Mez.[Methods]Silica gel column chromatography,gel column chromatography,recrystallization,high-performance preparative liquid chromatography and other modern separation methods and techniques were used to separate and purify the chemical components of the ethyl acetate fraction of the fruit of E.undulata(Wall.)Mez,and based on the physical and chemical properties and spectral data,their structure was identified.[Results]Six compounds were isolated from the fruit of E.undulata(Wall.)Mez,including trimethyl citrate(1),vanillic acid(2),5-hydroxymethylfurfural(3),1,5-dimethyl citrate(4),1,6-dimethyl-5-ethyl citrate(5)and 3,4-dihydroxybenzoic acid(6).[Conclusions]Compounds 1-6 are all isolated from E.undulata(Wall.)Mez for the first time.
文摘Panax pseudoginseng Wall., a highly medicinal, herbaceous, long-lived plant, grows in the forest litter of shady primary forest. The species is threatened in the natural habitat due to unsustainable harvesting of rhizome for medicine and habitat destruction. The species has very poor adaptive power to the synthetic environment and fails to grow and propagate. Present study was undertaken to develop suitable low cost propagation technique and produce clonal planting materials through rhizome splitting and root cutting. Rhizomes and roots were cut into segments and sowed in the raised soil bed prepared by mixing decayed wood powder, sand and top black soil at 1:1:3 ratios in a shaded poly house. Of the sowed rhizome segments ~55% segments remained recalcitrant to morphogenetic response in the first year of the study and the response improved in the subsequent years. In the third year ~51% rhizome segments responded positively. The horizontal root cuts mostly remained morphogenetically dormant but inclined root cuts exhibited better response. The morphogenetic response from the roots was comparatively very poor compare to rhizome segments. The plantlets formed both rhizome segments and root cuttings were maintained for three years in the bed/pots followed by transferring in the cultivated plots.
文摘Biological characteristics of Alternaria tenuissima on Dendrobium sandidium Wall. et Lindl. were studied. The result showed that A. tenuissima on D.sandidium Wall. et Lindl. could grow at temperature 5- 35 ℃ and p H value of 2- 10,the optimal temperature and p H value were 25℃ and 7 for its growth and sporulation,respectively. Starch was the optimal carbon sources and peptone was the optimal nitrogen source for the growth and sporulation of bacterial colony,respectively; PSA and PCA were the optimal media for its growth and sporulation,respectively.
基金funded by Key R&D Projects in Hubei Province (Grant No.2020BCA084)Innovative Group Project of Hubei Natural Science Foundation (Grant No.2020CFA043)。
文摘Prototype experiments were carried out on the explosion-proof performance of the RC blast wall.The mass of TNT detonated in the experiments is 5 kg and 20 kg respectively.The shock wave overpressure was tested in different regions.The above experiments were numerically simulated,and the simulated shock wave overpressure waveforms were compared with that tested and given by CONWEP program.The results show that the numerically simulated waveform is slightly different from the test waveform,but similar to CONWEP waveform.Through dimensional analysis and numerical simulation under different working conditions,the equation for the attenuation rate of the diffraction overpressure behind the blast wall was obtained.According to the corresponding standards,the degree of casualties and the damage degree of the brick concrete building at a certain distance behind the wall can be determined when parameters are set.The above results can provide a reference for the design and construction of the reinforced concrete blast wall.
基金National Key Research and Development Program of China under Grant No.2018YFC0705602。
文摘Frame and rocking wall(FRW)structures have excellent resilient performance during earthquakes.However,the concrete at interfacial corners of rocking walls(RWs)is easily crushed due to local extreme compression during the rocking process.An innovative RW with a curved interface is proposed to prevent interfacial corners from producing local damage,enhancing its earthquake resilient performance(ERP).The precast wall panel with a curved interface is assembled into an integral self-centering hybrid rocking wall(SCRW)by two post-tensioned unbonded prestressed tendons.Moreover,two ordinary energy dissipation steel rebars and two shear reinforcements are arranged to increase the energy dissipation capacity and lateral resistance.Two SCRW specimens and one monolithic reinforced concrete(RC)shear wall(SW)were tested under pseudo-static loading to compare the ERPs of the proposed SCRW and the SW,focusing on studying the effect of the curved interface on the SCRW.The key resilient performance of rocking effects,failure modes,and hysteretic properties of the SCRW were explored.The results show that nonlinear deformations of the SCRW are concentrated along the interface between the SCRW and the foundation,avoiding damage within the SCRW.The restoring force provided by the prestressed tendons can effectively realize self-centering capacity with small residual deformation,and the resilient performance of the SCRW is better than that of monolithic SW.In addition,the curved interface of the SCRW makes the rocking center change and move inward,partially relieving the stress concentration and crush of concrete.The rocking range of the rocking center is about 41.4%of the width of the SCRW.
文摘H-steel all-bolted connection steel frame structures with heat preservation and decoration composite wall boards were investigated and the seismic performances of three scaled specimens were studied.The failure modes,hysteresis curves,bearing capacity,ductility,energy dissipation capacity,stiffness degradation and strain distribution were discussed.The calculation method of structural theoretical internal force was presented.The results showed that the overall structural seismic performance was better,and the structural ductility met the demands of elastic-plastic inter-story drift angle for seismic design.The H-steel weak-axis connection structure obtained better energy dissipation capacity,and its bearing capacity and stiffness were slightly different from the strong-axis connection.The heat preservation and decoration performance of composite wallboard and the all-bolted connection of the steel frame realized prefabrication during the whole construction period.The plastic hinge of the steel beam can be moved outwards because of the L-angles,which effectively avoids stress concentration in joint areas and expands the plastic hinge range.The errors between the theoretical structural capacity calculated by the plastic analysis method and the test results were within 2.44%.In addition,structural failure mechanisms and bearing capacities were verified by the finite element(FE)analysis,and the effects of the main parameters on the structures were investigated.The FE verification results were the same as in the test.The research results provide theoretical support and technical guidance for the application of thermal insulation and decorative composite wall panels in H-shaped steel all-bolted steel frames.
基金supported by National Natural Science Foundation of China(12172308)National Key Research and Development Program of China(2020YFA0710902).
文摘Combining the detached eddy simulation(DES)method and Ffowcs Williams-Hawkings(FW-H)equation,the effect of bogie cavity end wall inclination on the flow field and aerodynamic noise in the bogie region is numerically studied.First,the simulation is conducted based on a simplified cavity-bogie model,including five cases with different inclination angles of the front and rear walls of the cavity.By comparing and analyzing the flow field and acoustic results of the five cases,the influence of the regularity and mechanism of the bogie cavity end wall inclination on the flow field and the aerodynamic noise of the bogie region are revealed.Then,the noise reduction strategy determined by the results of the simplified cavity-bogie model is applied to a three-car marshaling train model to verify its effectiveness when applied to the real train.The results reveal that the forward inclination of the cavity front wall enlarges the influence area of shear vortex structures formed at the leading edge of the cavity and intensifies the interaction between the vortex structures and the front wheelset,frontmotor,and front gearbox,resulting in the increase of the aerodynamic noise generated by the bogie itself.The backward inclination of the cavity rear wall is conducive to guiding the vortex structures flow out of the cavity and weakening the interaction between the shear vortex structures and the cavity rear wall,leading to the reduction of the aerodynamic noise generated by the bogie cavity.Inclining the rear end wall of the foremost bogie cavity of the head car is a feasible aerodynamic noise reduction measure for high-speed trains.
基金the Program of State Key Laboratory of Food Science and Technology,Nanchang University (SKLF-ZZB-202119)。
文摘The nutrient digestion,absorption and biological activity of bee pollen may be limited due to the complex pollen wall.Here,the effect of superfine grinding technology on the release of nutrients from bee pollen were investigated,and their antioxidant activities and in vitro digestion were explored in this study.Results showed that the content of nutrients in bee pollen increased after wall disruption.Among them,fat content increased by 22.55%-8.31%,protein content increased by 0.54%-4.91%,starch content increased by 36.31%-48.64%,soluble sugar content increased by 20.57%-29.67%,total phenolic acid content increased by 11.73%-86.98%and total flavonoids content increased by 14.29%-24.79%.At the same time,the antioxidant activity increased by 14.84%-46.00%.Furthermore,the active components such as phenolic compounds in the wall-disruption bee pollen were more readily to be released during the in vitro digestion,and easier to be absorbed because of their higher bioaccessibility.Antioxidant activities during in vitro digestion were also improved in walldisruption bee pollen.These findings provide evidence that bee pollen wall disruption was suggested,thus,it is more conducive to exerting the value of bee pollen in functional foods.
基金This research work was financially supported by the National Natural Science Foundation of China(Grant Nos.52078182 and 41877255)the Tianjin Municipal Natural Science Foundation(Grant No.20JCYBJC00630).Their financial support is gratefully acknowledged.
文摘To date,few models are available in the literature to consider the creep behavior of geosynthetics when predicting the lateral deformation(d)of geosynthetics-reinforced soil(GRS)retaining walls.In this study,a general hyperbolic creep model was first introduced to describe the long-term deformation of geosynthetics,which is a function of elapsed time and two empirical parameters a and b.The conventional creep tests with three different tensile loads(Pr)were conducted on two uniaxial geogrids to determine their creep behavior,as well as the a-Pr and b-Pr relationships.The test results show that increasing Pr accelerates the development of creep deformation for both geogrids.Meanwhile,a and b respectively show exponential and negatively linear relationships with Pr,which were confirmed by abundant experimental data available in other studies.Based on the above creep model and relationships,an accurate and reliable analytical model was then proposed for predicting the time-dependent d of GRS walls with modular block facing,which was further validated using a relevant numerical investigation from the previous literature.Performance evaluation and comparison of the proposed model with six available prediction models were performed.Then a parametric study was carried out to evaluate the effects of wall height,vertical spacing of geogrids,unit weight and internal friction angle of backfills,and factor of safety against pullout on d at the end of construction and 5 years afterwards.The findings show that the creep effect not only promotes d but also raises the elevation of the maximum d along the wall height.Finally,the limitations and application prospects of the proposed model were discussed and analyzed.
基金supported by Supported by the Science and Technology Research Program of the Institute of Mountain Hazards and Environment,CAS(IMHE-ZDRW-01)the National Natural Science Foundation of China,China(Grant Numbers:42077275&42271086)the Special Project of Basic Research-Key Project,Yunnan(Grant Number:202301AS070039).
文摘The present work aims to assess earthquake-induced earth-retaining(ER)wall displacement.This study is on the dynamics analysis of various earth-retaining wall designs in hollow precast concrete panels,reinforcement concrete facing panels,and gravity-type earth-retaining walls.The finite element(FE)simulations utilized a 3D plane strain condition to model full-scale ER walls and numerous nonlinear dynamics analyses.The seismic performance of differentmodels,which includes reinforcement concrete panels and gravity-type and hollowprecast concrete ER walls,was simulated and examined using the FE approach.It also displays comparative studies such as stress distribution,deflection of the wall,acceleration across the wall height,lateral wall displacement,lateral wall pressure,and backfill plastic strain.Three components of the created ER walls were found throughout this research procedure.One is a granular reinforcement backfill,while the other is a wall-facing panel and base foundation.The dynamic response effects of varied earth-retaining walls have also been studied.It was discovered that the facing panel of the model significantly impacts the earthquake-induced displacement of ER walls.The proposed analytical model’s validity has been evaluated and compared with the reinforcement concrete facing panels,gravity-type ER wall,scientifically available data,and American Association of State Highway and Transportation Officials(AASHTO)guidelines results based on FE simulation.The results of the observations indicate that the hollow prefabricated concrete ER wall is the most feasible option due to its lower displacement and high-stress distribution compared to the two types.The methodology and results of this study establish standards for future analogous investigations and professionals,particularly in light of the increasing computational capabilities of desktop computers.
文摘The impact sensitivity assessment of spacecraft is to obtain the probability of spacecraft encountering the OD/M(orbital debris or meteoroid),which is a prerequisite for survivability assessment of on-orbit spacecraft.An impact sensitivity assessment method of spacecraft based on virtual exterior wall was proposed to improve the computational efficiency.This method eliminates determination of the outermost surface elements of the spacecraft before generating the debris rays,which are assumed to originate from a non-concave virtual wall that completely wraps the spacecraft.The Dist Mesh method was adopted for the generating of the virtual wall to ensure its mesh quality.The influences of the sizes,mesh densities,shapes of the virtual wall on the efficiency and accuracy were considered to obtain the best combination of the size and mesh density of the wall and spacecraft.The results of this method were compared with those of S3DE(Survivability of Spacecraft in Space Debris Environment),BUMPER,MDPANTO,ESABASE2/Debris to verify the feasibility of the method.The PCHIP(Piecewise Cubic Hermite Interpolating Polynomial)was used to fit the size vs.flux relationship of the space debris to acquire the impact probability of OD/M with arbitrary size on the spacecraft.
基金Hunan Provincial key Laboratory of key Technology on Hydropower Development Open Research Fund (PKLHD202203)
文摘Rock avalanches are generally difficult to prevent and control due to their high velocities and the extensive destruction they cause.However,barrier structures constructed along the path of a rock avalanche can partially mitigate the magnitudes and consequences of such catastrophic events.We selected a rock avalanche in Nayong County,Guizhou Province,China as a case to study the effect of the location and height of a retaining wall on the dynamic characteristics of rock avalanche by using both actual terrain-based laboratory-model tests and coupled PFC3D-FLAC3D numerical simulations.Our findings demonstrate that a retaining wall can largely block a rock avalanche and its protective efficacy is significantly influenced by the integrity of the retaining wall.Coupled numerical simulation can serve as a powerful tool for analyzing the interaction between a rock avalanche and a retaining wall,facilitating precise observations of its deformation and destruction.The impact-curve characteristics of the retaining wall depend upon whether or not the rock avalanche-induced destruction is taken into account.The location of the retaining wall exerts a greater influence on the outcome compared to the height and materials of the retaining wall,while implementing a stepped retaining-wall pattern in accordance with the terrain demonstrates optimal efficacy in controlling rock avalanche.
文摘BACKGROUND Malignant triton tumors(MTTs)comprise a subgroup of malignant peripheral nerve sheath tumors(MPNSTs)that exhibits rhabdomyosarcomatous differen-tiation and follow an aggressive course.MTTs are primarily located along peripheral nerves.Cases of MTTs in the abdominal wall have not been reported.MTT has a poorer prognosis than classic MPNSTs,and accurate diagnosis necessitates a keen understanding of the clinical history and knowledge of its differential diagnosis intricacies.Treatment for MTTs mirrors that for MPNSTs and is predominantly surgical.CASE SUMMARY A 49-year-old woman presented with a subcutaneous mass in her lower abdo-minal wall and a pre-existing surgical scar that had grown slowly over 3-4 months before the consultation.She had previously undergone radical hysterectomy and concurrent chemo-radiotherapy for cervical cancer approximately 5 years prior to the consultation.Abdominal computed tomography(CT)showed a 1.3 cm midline mass in the lower abdomen with infiltration into the rectus abdominis muscle.There was no sign of metastasis(T1N0M0).An incisional biopsy identified sporadic MTT of the lower abdomen.A comprehensive surgical excision with a 3 cm margin inclusive of the peritoneum was executed.Subse-quently,the general surgeon utilized an approach akin to the open peritoneal onlay mesh technique.The patient underwent additional treatment with an excision shaped as a mini-abdominoplasty for the skin defect.No complications arose,and annual follow-up CTs did not show signs of recurrence or metastasis.CONCLUSION An abdominal MTT was efficaciously treated with extensive excision and abdominal wall reconstruction,eliminating the need for postoperative radiotherapy.
基金Supported by National Natural Science Foundation of China,No.82071871Guangdong Basic and Applied Basic Research Foundation,No.2021A1515220131+1 种基金Guangdong Medical Science and Technology Research Fund Project,No.2022111520491834Clinical Research Project of Shenzhen Second People's Hospital,No.20223357022。
文摘BACKGROUND Intracranial atherosclerosis,a leading cause of stroke,involves arterial plaque formation.This study explores the link between plaque remodelling patterns and diabetes using high-resolution vessel wall imaging(HR-VWI).AIM To investigate the factors of intracranial atherosclerotic remodelling patterns and the relationship between intracranial atherosclerotic remodelling and diabetes mellitus using HR-VWI.METHODS Ninety-four patients diagnosed with middle cerebral artery or basilar artery INTRODUCTION Intracranial atherosclerotic disease is one of the main causes of ischaemic stroke in the world,accounting for approx-imately 10%of transient ischaemic attacks and 30%-50%of ischaemic strokes[1].It is the most common factor among Asian people[2].The adaptive changes in the structure and function of blood vessels that can adapt to changes in the internal and external environment are called vascular remodelling,which is a common and important pathological mechanism in atherosclerotic diseases,and the remodelling mode of atherosclerotic plaques is closely related to the occurrence of stroke.Positive remodelling(PR)is an outwards compensatory remodelling where the arterial wall grows outwards in an attempt to maintain a constant lumen diameter.For a long time,it was believed that the degree of stenosis can accurately reflect the risk of ischaemic stroke[3-5].Previous studies have revealed that lesions without significant luminal stenosis can also lead to acute events[6,7],as summarized in a recent meta-analysis study in which approximately 50%of acute/subacute ischaemic events were due to this type of lesion[6].Research[8,9]has pointed out that the PR of plaques is more dangerous and more likely to cause acute ischaemic stroke.Previous studies[10-13]have found that there are specific vascular remodelling phenomena in the coronary and carotid arteries of diabetic patients.However,due to the deep location and small lumen of intracranial arteries and limitations of imaging techniques,the relationship between intracranial arterial remodelling and diabetes is still unclear.In recent years,with the development of magnetic resonance technology and the emergence of high-resolution(HR)vascular wall imaging,a clear and multidimensional display of the intracranial vascular wall has been achieved.Therefore,in this study,HR wall imaging(HR-VWI)was used to display the remodelling characteristics of bilateral middle cerebral arteries and basilar arteries and to explore the factors of intracranial vascular remodelling and its relationship with diabetes.
基金Supported by Shenzhen Science and Technology Research and Development Fund,No.JSGG20210802153548040.
文摘BACKGROUND Gastric wall necrosis is a rare complication of endoscopic treatment for bleeding gastric ulcer,which may exacerbate the patient’s condition once it occurs and may even require surgical intervention for treatment.CASE SUMMARY A 59-year-old man was admitted to our department with melena.Endoscopy revealed a giant ulcer in the gastric antrum with a visible vessel in its center,which was treated with sclerosants and tissue glue injection and resulted in necrosis of the gastric wall.CONCLUSION Injection of sclerosants and tissue glue may lead to gastric wall necrosis,which is a serious complication.Therefore,before administering this treatment to patients,we should consider other more effective methods of hemostasis to avoid gastric wall necrosis.
基金Supported by National Natural Science Foundation of China,No.82260412.
文摘BACKGROUND Hepatic cystic and alveolar echinococcosis coinfections,particularly with concurrent abscesses and sinus tract formation,are extremely rare.This article presents a case of a patient diagnosed with this unique presentation,discussing the typical imaging manifestations of both echinococcosis types and detailing the diagnosis and surgical treatment experience thereof.CASE SUMMARY A 39-year-old Tibetan woman presented with concurrent hepatic cystic and alveolar echinococcosis,accompanied by abdominal wall abscesses and sinus tract formation.Initial conventional imaging examinations suggested only hepatic cystic echinococcosis,but intraoperative and postoperative pathological examination revealed the coinfection.Following radical resection of the lesions,the patient’s condition improved,and she was discharged soon thereafter.Subsequent outpatient follow-ups confirmed no recurrence of the hydatid lesion and normal surgical wound healing.Though mixed hepatic cystic and alveolar echinococcosis with abdominal wall abscesses and sinus tract formations are rare,the general treatment approach remains consistent with that of simpler infections of alveolar echinococcosis.CONCLUSION Lesions involving the abdominal wall and sinus tract formation,may require radical resection.Long-term prognosis includes albendazole and follow-up examinations.
