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Eruptive xanthomas in a patient with severe hypertriglyceridemia:A case report
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作者 Ci Ren Ling Zhu +3 位作者 Yan-Chao Niu Lian-Yu Tu Zhou-Feng Jin Jian Zhang 《World Journal of Clinical Cases》 SCIE 2024年第16期2842-2846,共5页
BACKGROUND Xanthomatosis,a metabolic disorder causing yellow growths(xanthomas),poses challenges in lipid metabolism.This case study introduces the first documented instance within China's Yi population,emphasizin... BACKGROUND Xanthomatosis,a metabolic disorder causing yellow growths(xanthomas),poses challenges in lipid metabolism.This case study introduces the first documented instance within China's Yi population,emphasizing the need to explore dietary habits and treatment strategies tailored to this specific community.CASE SUMMARY Xanthomatosis is a metabolic disorder where lipid metabolism goes awry,resulting in the development of yellowish growths called xanthomas.A male patient,47 years of age,from China's Yi population,who is obese,visited our dermatology clinic complaining of widespread,non-painful rashes that have been present for two weeks.The patient works as a chef and has a diet that frequently includes oily and greasy foods.This case represents the initial documentation of xanthomatosis within the Yi population in China,offering a theoretical foundation for understanding dietary patterns and treatment options specific to the Yi community.CONCLUSION The first report of xanthomatosis in the Yi population in China lays a theoretical foundation for understanding Yi dietary patterns and treatment. 展开更多
关键词 Eruptive xanthomas HYPERTRIGLYCERIDEMIA Yi ethnicity DERMATOLOGY Chef Case report
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Alagille syndrome associated with total anomalous pulmonary venous connection and severe xanthomas:A case report
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作者 Han-Shi Zeng Zhan-Hui Zhang +4 位作者 Yan Hu Gui-Lang Zheng Jing Wang Jing-Wen Zhang Yu-Xiong Guo 《World Journal of Clinical Cases》 SCIE 2022年第25期8932-8938,共7页
BACKGROUND Alagille syndrome(ALGS)is an autosomal dominant genetic disorder caused by mutations in the JAG1 or NOTCH2 gene.It is characterized by decreased intrahepatic bile ducts associated with a variety of abnormal... BACKGROUND Alagille syndrome(ALGS)is an autosomal dominant genetic disorder caused by mutations in the JAG1 or NOTCH2 gene.It is characterized by decreased intrahepatic bile ducts associated with a variety of abnormalities in many other organ systems,such as the cardiovascular,skeletal,and urinary systems.CASE SUMMARY We report a rare case of ALGS.A 1-month-old male infant presented with sustained jaundice and had a rare congenital heart disease:Total anomalous pulmonary venous connection(TAPVC).Sustained jaundice,particularly with cardiac murmur,caught our attention.Laboratory tests revealed elevated levels of alanine aminotransferase,aspartate aminotransferase,gamma-glutamyl transpeptidase,total bilirubin,and total bile acids,indicating serious intrahepatic cholestasis.Imaging confirmed the presence of butterfly vertebra at the seventh thoracic vertebra.This suggested ALGS,which was confirmed by genetic testing with a c.3197dupC mutation in the JAG1 gene.Ursodiol was administered immediately after confirmation of the diagnosis,and cardiac surgery was performed when the patient was 1.5 month old.He recovered well after treatment and was discharged at the age of 3 mo.At the age of two years,the patient returned to our clinic because multiple cutaneous nodules with xanthomas appeared,and their size and number increased over time.CONCLUSION We report a unique case of ALGS associated with TAPVC and severe xanthomas.This study has enriched the clinical manifestations of ALGS and emphasized the association between JAG1 gene and TAPVC. 展开更多
关键词 Alagille syndrome JAG1 gene Notch signaling pathway Total anomalous pulmonary venous connection Severe xanthomas Case report
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Pleomorphic cutaneous xanthomas disclosing homozygous familial hypercholesterolemia
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作者 Antonio Mastrolorenzo Antonietta D'Errico +3 位作者 Piera Pierotti Margherita Vannucchi Stefano Giannini Fiammetta Fossi 《World Journal of Dermatology》 2017年第4期59-65,共7页
Homoxygous Familial Hypercholesterolemia is characterized by a presence of several types of cutaneous xanthomas with an abnormal lipid profile. Some of these could be pathognomonic. Although these could be initially i... Homoxygous Familial Hypercholesterolemia is characterized by a presence of several types of cutaneous xanthomas with an abnormal lipid profile. Some of these could be pathognomonic. Although these could be initially interpreted as isolated and localized benign disorders and offered surgical treatment, it has become increasingly clear that they could be a part of a systemic pathology. Here we describe a case of this rare disorder in a 19 years old non-obese young man who presented multiple, intertriginous, tuberous and tendinous xanthomas and had an associated abnormal lipid profile with elevated lowdensity lipoprotein cholesterol levels. A detailed history with clinical assessment in the differential diagnosis and laboratory investigations led to a precise diagnosis. 展开更多
关键词 Intertriginous xanthomas Homoxygous FAMILIAL HYPERCHOLESTEROLEMIA FAMILIAL HYPERCHOLESTEROLEMIA DYSLIPIDEMIA xanthomas
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Eruptive xanthomas associated with diabetes mellitus
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作者 Ivana Binic Aleksandar Jankovic 《Chinese Medical Journal》 SCIE CAS CSCD 2009年第17期2074-2075,共2页
Diabetes mellitus (DM) is a most common endocrine disorder and it is characterized by high serum glucose levels and by disturbance of lipid metabolism. As a result, the patients can develop long-term systemic compli... Diabetes mellitus (DM) is a most common endocrine disorder and it is characterized by high serum glucose levels and by disturbance of lipid metabolism. As a result, the patients can develop long-term systemic complications. Numerous skin lesions are associated with either type 1 or type 2 diabetes mellitus, and they are specific chronic complications of the disease. Cutaneous xanthomas result from deposition of lipids in the histiocytes in the dermis or subcutaneous tissue. Eruptive xanthomas are a characteristic, but uncommon complication of diabetes mellitus associated with a more sustained hyperlipidemia affecting plasma triglycerides and cholesterol, and hyperglycemia with glycosuria. 展开更多
关键词 eruptive xanthomas diabetes mellitus HYPERTRIGLYCERIDEMIA HYPERCHOLESTEROLEMIA
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Gastric xanthoma is a predictive marker for metachronous and synchronous gastric cancer 被引量:9
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作者 Narihiro Shibukawa Shohei Ouchi +2 位作者 Shuji Wakamatsu Yuhei Wakahara Akira Kaneko 《World Journal of Gastrointestinal Oncology》 SCIE CAS 2017年第8期327-332,共6页
To investigate predictive markers for metachronous and synchronous gastric cancer (GC), which can develop after endoscopic submucosal dissection (ESD). METHODSA total of 352 patients underwent ESD for early GC at NTT ... To investigate predictive markers for metachronous and synchronous gastric cancer (GC), which can develop after endoscopic submucosal dissection (ESD). METHODSA total of 352 patients underwent ESD for early GC at NTT West Osaka Hospital between June 2006 and February 2016. Exclusion criteria were as follows: Remnant stomach, unknown Helicobacter pylori status, and endoscopic observation of the whole stomach outside our hospital. We analyzed data from 192 patients comprising 109 patients with solitary GC (Group A) and 83 with metachronous and synchronous GC (Group B). We retrospectively investigated the clinicopathological and endoscopic characteristics, and endoscopic risk score as predictive markers for GC. RESULTSThe median age of Group B [72 years (interquartile range 63-78)] was significantly higher than that of Group A [66 years (interquartile range 61-74), respectively, P = 0.0009]. The prevalence of intestinal metaplasia in Group B tended to be higher than that in Group A (57.8% vs 45.0%, P = 0.08). The prevalence of gastric xanthoma (GX) in Group B was significantly higher than that in Group A (54.2% vs 32.1%, P = 0.003). The atrophy score in Group B was significantly higher than that in Group A (P = 0.005). Multivariate analysis revealed that higher age and the presence of GX were independently related to metachronous and synchronous GC [OR = 1.04 (1.01-1.08), P = 0.02; and OR = 2.11 (1.14-3.99), P = 0.02, respectively]. CONCLUSIONThe presence of GX is a useful predictive marker for metachronous and synchronous GC. 展开更多
关键词 Gastric cancer Metachronous neoplasms Synchronous neoplasms XANTHOMA BIOMARKER
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Giant xanthogranuloma of the pelvis with S1 origin: Complete removal with only posterior approach, technical note
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作者 Nicola Marotta Alessandro Landi +5 位作者 Cristina Mancarella Pierluigi Rocco Andrea Pietrantonio Gaspare Galati Antonio Bolognese Roberto Delfini 《World Journal of Clinical Cases》 SCIE 2015年第1期77-80,共4页
Xanthogranulomas(XG) are benign proliferative disorder of histiocytes, a non-Langerhans cell histiocytosis. Whose etiology is unknown. The nature of these lesions is controversial and could be either reactive or neopl... Xanthogranulomas(XG) are benign proliferative disorder of histiocytes, a non-Langerhans cell histiocytosis. Whose etiology is unknown. The nature of these lesions is controversial and could be either reactive or neoplastic;the presence of monoclonal cells does, however, favor the second hypothesis. Xanthogranuloma is frequently found in young adults and children(under 20 years old), mainly in the skin. In about 5%-10% of all Juvenile XG(JXG) cases xanthogranuloma are extracutaneous. Within this group, the site most frequently involved is the eye. Other involved organs are heart, liver, adrenals, oropharynx, lung, spleen, central nervous system and subcutaneous tissue, although involvement of the spine is uncommon. Isolated lesions involving the sacral region are extremely rare. To date, this is the first reported case of a giant JXG arising from S1 with extension into the pelvic region in an adult spine. 展开更多
关键词 Xanthogranulomas Non-Langerhans cell HISTIOCYTOSIS Touton GIANT cells Congenital XANTHOMA NEUROFIBROMATOSIS
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Cutaneous markers of coronary artery disease
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作者 Shridhar Dwivedi Rajat Jhamb 《World Journal of Cardiology》 CAS 2010年第9期262-269,共8页
Coronary artery disease (CAD) is rapidly increasing in prevalence across the world and particularly in south Asians at a relatively younger age. As atherosclerosis starts in early childhood, the process of risk evalua... Coronary artery disease (CAD) is rapidly increasing in prevalence across the world and particularly in south Asians at a relatively younger age. As atherosclerosis starts in early childhood, the process of risk evaluation must start quite early. The present review addresses the issue of cutaneous markers associated with atherosclerosis, and the strengths and weaknesses of the markers in identifying early coronary atherosclerosis. A diligent search for such clinical markers, namely xanthelasma, xanthoma, arcus juvenilis, acanthosis nigricans, skin tags, ear lobe crease, nicotine stains, premature graying in smokers, hyperpigmented hands in betel quid sellers, central obesity, and signs of peripheral vascular disease may prove to be a rewarding exercise in identifying asymptomatic CAD in high risk individuals. 展开更多
关键词 CUTANEOUS MARKERS CORONARY artery disease XANTHOMA Arcus juvenilis Acanthosis nigricans NICOTINE
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Bilateral primary xanthoma of the humeri with pathologic fractures: A case report
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作者 Sayed Ali Alex Fedenko +4 位作者 Ali B Syed George Matcuk Dakshesh Patel Chris Gottsegen Eric White 《World Journal of Radiology》 CAS 2013年第9期345-348,共4页
Xanthomas are rare bone tumors that occur more often in the appendicular skeleton and typically appear radiographically benign,with a narrow zone of transition and a sclerotic rim.We report the case of a 57-year-old w... Xanthomas are rare bone tumors that occur more often in the appendicular skeleton and typically appear radiographically benign,with a narrow zone of transition and a sclerotic rim.We report the case of a 57-year-old woman with hyperlipidemia presenting with bilateral shoulder pain after minor trauma.Radiographic and histopathologic investigation demonstrated intraosseous xanthoma with atypical features,including multifocality,a wide zone of transition and pathologic fractures-characteristics more commonly associated with aggressive lesions such as multiple myeloma or metastasis.The diagnosis,imaging,and histological appearance of xanthoma of bone are reviewed. 展开更多
关键词 XANTHOMA HYPERLIPIDEMIA PATHOLOGIC FRACTURE
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Diffuse xanthoma in early esophageal cancer: A case report
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作者 Xiao-Yun Yang Kuang-I Fu +2 位作者 Yan-Ping Chen Zhen-Wei Chen Jing Ding 《World Journal of Clinical Cases》 SCIE 2021年第19期5259-5265,共7页
BACKGROUND Gastrointestinal xanthomas are asymptomatic and infrequent non-neoplastic lesions that commonly occur in the stomach with Helicobacter pylori-associated gastritis and rarely in the esophagus.To date,there h... BACKGROUND Gastrointestinal xanthomas are asymptomatic and infrequent non-neoplastic lesions that commonly occur in the stomach with Helicobacter pylori-associated gastritis and rarely in the esophagus.To date,there have been no reports of esophageal xanthoma combined with esophageal cancer.Herein,we present the first case in the literature of a diffuse xanthoma complicated with early esophageal cancer.Moreover,this combination makes the endoscopic diagnosis difficult if it is not in mind.CASE SUMMARY A 68-year-old man visited our department with a 2-mo history of epigastric discomfort.He underwent surgery for gastric cancer 6 years ago.Esophagogastroduodenoscopy showed a semi-circumferential irregular yellowish-colored and granular lesion in the esophagus(30-35 cm from the incisors).Using magnifying endoscopy with narrow band imaging,aggregated minute and yellowish-colored spots with tortuous microvessels on the surface were observed,and background coloration was clearly seen in the lesion.As endoscopic biopsy suggested a histologically high-grade dysplasia;the lesion was completely resected en bloc by endoscopic submucosal dissection(ESD).The resected specimen was confirmed to be a squamous cell carcinoma in situ with extensive foamy cells in the superficial mucosal layer.Immunohistochemically,the observed foamy cells were strongly positive for CD68,which is characteristic of xanthoma.The clinical course was favorable,and no recurrence was observed 2 years and 7 mo after ESD.CONCLUSIONDiffuse xanthoma concurrent with early esophageal cancer is extremely rare.The characteristic endoscopic features may assist endoscopists in diagnosing similar lesions. 展开更多
关键词 Esophageal xanthoma Early esophageal cancer Magnifying endoscopy Endoscopic submucosal dissection Case report
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Progressive ataxia of cerebrotendinous xanthomatosis with a rare c.255+1G>T splice site mutation:A case report
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作者 Yue-Yue Chang Chuan-Qing Yu Lei Zhu 《World Journal of Clinical Cases》 SCIE 2022年第29期10681-10688,共8页
BACKGROUND Cerebrotendinous xanthomatosis is an autosomal recessive disorder of lipid metabolism caused by the mutation of the CYP27A1 gene encoding sterol 27-hydroxylase,an essential enzyme for the conversion of chol... BACKGROUND Cerebrotendinous xanthomatosis is an autosomal recessive disorder of lipid metabolism caused by the mutation of the CYP27A1 gene encoding sterol 27-hydroxylase,an essential enzyme for the conversion of cholesterol to chenodeoxycholic and cholic acids.Cerebrotendinous xanthomatosis is a rare neurological dis-ease with a wide range of clinical symptoms that are easily misdiagnosed.CASE SUMMARY Here we report the clinical,biochemical,and molecular characterization of a 33-year-old female patient with cerebrotendinous xanthomatosis.The patient developed ataxia and had the typical symptoms of juvenile cataracts,tendon xanthomata,and progressive nervous system dysfunction.Magnetic resonance imaging of the brain revealed bilateral dentate nucleus lesions and white matter abnormalities.This patient was misdiagnosed for 2 years resulting in severe neurological complications.After 2 years of chenodeoxycholic acid treatment,she still presented with ataxia and dysarthria.The pathogenic sites of CYP27A1 were identified as c.255+1G>T and c.1263+1G>T,which were both caused by shear denaturation.CONCLUSION Cerebrotendinous xanthomatosis requires a multidisciplinary diagnosis that must be made early to avoid progressive neurological degeneration.c.1263+1G>T is a known mutation,but c.255+1G>T is a rare mutation site. 展开更多
关键词 Cerebrotendinous xanthomatosis CYP27A1 gene ATAXIA Juvenile cataracts Tendon xanthoma Lipid metabolism Case report
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Histopathological, Immunohistochemical and Exfoliative Cytological Studies of Oral Verruciform Xanthoma
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作者 Tadahiko Utsunomiya Takashi Matsumoto +6 位作者 Miyuki Morikawa Masaaki Suemitsu Hidekuni Tanaka Yasuto Ota Takaaki Saito Hirotsugu Yamamoto Kayo Kuyama 《Open Journal of Stomatology》 2014年第9期435-440,共6页
Verruciform xanthoma is a rare tumor-like lesion, predominantly affecting the oral mucosa. Although several studies of verruciform xanthoma have been reported, the characteristic features and pathogenesis have not bee... Verruciform xanthoma is a rare tumor-like lesion, predominantly affecting the oral mucosa. Although several studies of verruciform xanthoma have been reported, the characteristic features and pathogenesis have not been fully clarified. The purpose of the present study is to perform immunohistochemical analysis using markers of proliferative cell activity and cytokeratins, and to perform comparative analysis between cytological and histological features in order to clarify the characteristic features of verruciform xanthomas. Histological findings showed exophitic proliferation of stratified squamous epithelium and accumulation of foamy macrophages between epithelial processes. Immunohistochemically, accumulated foamy cells showed positive immuno-reactivity for CD68, and positive cells were also present in the epithelium. Expression of pancy-tokeratin was observed in most layers of the epithelium, whereas cytokeratin 13 was also detected in prickle cell layers. Positive reactivity for Ki-67 was observed in epithelial cell nuclei. Positive reactivity was largely distributed in basal and/or parabasal cell layers, and the positive cell rate was 20%. In addition, exfoliative cytological findings showed hyperkeratotic epithelial cells with picnosis, thus suggesting the characteristics of hyperplastic epithelium in verruciforma, although foamy cells were not observed in the cytological specimens. These results suggest that benign morphological characteristics with local cellular immune response of verruciform xanthoma may be evaluated based on immunohistochemical expression of cytokeratin and Ki-67, as well as exfoliative cytological findings. 展开更多
关键词 ORAL Verruci Form XANTHOMA Histopathology Immunohistochemistry EXFOLIATIVE CYTOLOGY
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Bilateral Achilles Tendon Xanthoma in an 18-Year-Old Patient
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作者 S. K. Venkatesh Gupta B. Sahithya S. P. Prashanth 《Open Journal of Orthopedics》 2017年第4期110-116,共7页
Background: Xanthomas are rare, non-neoplastic lesions which occur due to defect in the LDL receptors leading to their accumulation in tendons and synovium. The prevalence of heterozygous familial hypercholesterolaemi... Background: Xanthomas are rare, non-neoplastic lesions which occur due to defect in the LDL receptors leading to their accumulation in tendons and synovium. The prevalence of heterozygous familial hypercholesterolaemia (HFH) is approximately 1 in 500. Aim: To study a rare case of bilateral achilles tendon xanthoma and its functional outcome. Case Presentation: We presented a case of xanthoma over posterior aspect of both lower third legs just above the heel in an 18-year-old female, and diagnosis was confirmed by clinical examination ultrasound and MRI, for which subtotal resection was planned and further followed up. Postoperative treatment consisted of six weeks long leg cast immobilization. After 10 weeks the patient started walking without any difficulties. Conclusion: Subtotal resection of achilles tendon xanthoma has given a good functional outcome. There is no need for reconstruction of tendon in every case. 展开更多
关键词 ACHILLES TENDON XANTHOMA Low Density LIPOPROTEIN Magnetic Resonance Imaging Ultrasound
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Bilateral Tibial Xanthoma in a Normolipidemic Patient—Report of a Rare Case with Review of Literature
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作者 Vallabhaneni Kalyan Chakravarthi E. Aruna +1 位作者 Damera Naveen Chandra Rao Diddi Ranga Rao 《International Journal of Clinical Medicine》 2012年第3期234-237,共4页
Xanthoma of bone is a rare benign bone disorder. It radiologically presents as a lytic lesion, often with cortical expansion or disruption, mimics primary bone tumors and metastatic lesions. Histopathological study gi... Xanthoma of bone is a rare benign bone disorder. It radiologically presents as a lytic lesion, often with cortical expansion or disruption, mimics primary bone tumors and metastatic lesions. Histopathological study gives the definitive diagnosis. Xanthoma of bilateral tibia in a normolipidemic patient is rare and not yet reported in literature. Here with we present one such rare case, with review of literature. 展开更多
关键词 XANTHOMA Normolipidic TIBIA LYTIC LESION
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An unexpected urinary bladder xanthoma:Case report
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作者 Martina Mandarano Guido Bellezza +3 位作者 Giovanni Cochetti Giulio Metro Ettore Mearini Rachele Del Sordo 《临床与病理杂志》 CAS 2021年第10期2227-2230,共4页
In spite of the fact that xanthomas of the skin,tendons and mucosae are relatively common conditions,urinary bladder xanthoma is a rare benign lesion,only occasionally reported in literature.It usually appears as an e... In spite of the fact that xanthomas of the skin,tendons and mucosae are relatively common conditions,urinary bladder xanthoma is a rare benign lesion,only occasionally reported in literature.It usually appears as an exophytic mass into the bladder cavity,which often worries the clinicians,because it is considered as a neoplasm that need both an excision and follow-up.We herein describe the 32nd case,accidentally identified in a 63-year-old man with a right urinary bladder mass on follow-up abdominal ultrasound scan for a previous open pyeloplasty.He also referred mild obstructive lower urinary tract symptoms.Consequently,a cystoscopy with biopsies was performed and the subsequent histopathological examination was consistent with the diagnosis of urinary bladder xanthoma.Therefore,no additional therapeutics interventions were needed,and the patient currently presents nor symptoms,recurrences,or other pathologies.Although its rarity,it is important to correctly identify urinary bladder xanthoma,differentiating it from other pathological entities which present similar histopathological characteristics,but which sometimes could be associated with a patients’dismal prognosis.Moreover,an accurate diagnosis of urinary bladder xanthoma can avoid both additional treatments and follow up,but also allows to recognize some potential detrimental pathologies which could be associated with it,such as either an altered lipid metabolism or urothelial neoplasms.Proper and prompt recognition and treatment of these last can notably improve patient’s outcome. 展开更多
关键词 Urinary bladder xanthoma(UBX) rare urinary bladder lesion incidental urological finding case report
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Verruciform xanthoma of the penis:report of a case 被引量:2
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作者 夏同礼 李贵忠 +1 位作者 那彦群 郭应禄 《Chinese Medical Journal》 SCIE CAS CSCD 2004年第1期150-152,共3页
关键词 XANTHOMA PENIS HISTOLOGY
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