Objective:To observe the sustained expression of transient outward potassium channel related proteins at the end of the treatment and 30 days after the end of the treatment in rats,and to explore the sustained curativ...Objective:To observe the sustained expression of transient outward potassium channel related proteins at the end of the treatment and 30 days after the end of the treatment in rats,and to explore the sustained curative effect and mechanism of acupuncture combined with Xijingtongmai decoction in rats with myocardial infarction.Methods:Twenty of 130 male SD rats were random extracted as the control group,and the rest were used to establish myocardial infarction by fed with high-fat diet and then injected with isoproterenol.According to ECG,80 rats were successfully established.Then they were randomly divided into model group,acupuncture combined with Chinese medicine group,acupuncture group and Western medicine group.The content of bFGF protein was measured by ELISA.The protein contents of Kv1.4,Kv4.2,Kv4.3 and KChIP2 were measured by Western blot.Results:At the end of treatment,compared with the model group,the protein contents of Kv1.4,Kv4.2,Kv4.3,KChIP2 and bFGF in each treatment group increased,and the increase was most significant in the acupuncture combined with Chinese medicine group(P<0.05).At the end of treatment,compared with the model group,the protein contents of Kv1.4,Kv4.2,Kv4.3,KChIP2 and bFGF in each treatment group increased,and the increase was most significant in the acupuncture combined with Chinese medicine group(P<0.05).Compared with the treatment group at the end of treatment,the expression of Kv1.4,Kv4.2,Kv4.3,KChIP2 and bFGF protein in each treatment group 30 days after the end of treatment decreased slightly(P<0.05),but still higher than that of the model group at this time(P<0.05).The combination of acupuncture and Chinese medicine group decreased the least of them(P<0.05).Conclusion:The results showed that acupuncture combined with xijingtongmai decoction had a sustained good effect.Its sustained action mechanism may be achieved by continuously increasing the protein content of Kv1.4,Kv4.2,Kv4.3,KChIP2 and bFGF through transient outward potassium channel.展开更多
Warmly welcome Prof.Peter Wiedemann(middle),President of ICO/General Advisor of IJO to visit IJO Press Prof.Peter Wiedemann gave some guidance to IJO,recognized that it is a high-quality academic journal,and expected ...Warmly welcome Prof.Peter Wiedemann(middle),President of ICO/General Advisor of IJO to visit IJO Press Prof.Peter Wiedemann gave some guidance to IJO,recognized that it is a high-quality academic journal,and expected that it will make a greater contribution to the world ophthalmology.展开更多
In this paper, three types of green spaces in Xijing Community in Shijingshan District of Beijing were selected for as the measuring points, the HOBO portable weather station was used to monitor the microclimate envir...In this paper, three types of green spaces in Xijing Community in Shijingshan District of Beijing were selected for as the measuring points, the HOBO portable weather station was used to monitor the microclimate environmental changes in the same period and summarize the data of microclimate factors. The effectiveness of the simulation was verified by comparing the measured data with the simulated data obtained through ENVI-met. And strategies for microclimate adaptive design in residential areas were proposed according to the microclimate environmental characteristics of several green spaces.展开更多
基金Key project of Liaoning provincial science and technology foundation(No.20180530079)。
文摘Objective:To observe the sustained expression of transient outward potassium channel related proteins at the end of the treatment and 30 days after the end of the treatment in rats,and to explore the sustained curative effect and mechanism of acupuncture combined with Xijingtongmai decoction in rats with myocardial infarction.Methods:Twenty of 130 male SD rats were random extracted as the control group,and the rest were used to establish myocardial infarction by fed with high-fat diet and then injected with isoproterenol.According to ECG,80 rats were successfully established.Then they were randomly divided into model group,acupuncture combined with Chinese medicine group,acupuncture group and Western medicine group.The content of bFGF protein was measured by ELISA.The protein contents of Kv1.4,Kv4.2,Kv4.3 and KChIP2 were measured by Western blot.Results:At the end of treatment,compared with the model group,the protein contents of Kv1.4,Kv4.2,Kv4.3,KChIP2 and bFGF in each treatment group increased,and the increase was most significant in the acupuncture combined with Chinese medicine group(P<0.05).At the end of treatment,compared with the model group,the protein contents of Kv1.4,Kv4.2,Kv4.3,KChIP2 and bFGF in each treatment group increased,and the increase was most significant in the acupuncture combined with Chinese medicine group(P<0.05).Compared with the treatment group at the end of treatment,the expression of Kv1.4,Kv4.2,Kv4.3,KChIP2 and bFGF protein in each treatment group 30 days after the end of treatment decreased slightly(P<0.05),but still higher than that of the model group at this time(P<0.05).The combination of acupuncture and Chinese medicine group decreased the least of them(P<0.05).Conclusion:The results showed that acupuncture combined with xijingtongmai decoction had a sustained good effect.Its sustained action mechanism may be achieved by continuously increasing the protein content of Kv1.4,Kv4.2,Kv4.3,KChIP2 and bFGF through transient outward potassium channel.
文摘Warmly welcome Prof.Peter Wiedemann(middle),President of ICO/General Advisor of IJO to visit IJO Press Prof.Peter Wiedemann gave some guidance to IJO,recognized that it is a high-quality academic journal,and expected that it will make a greater contribution to the world ophthalmology.
基金Sponsored by 2018 Beijing Municipal University Academic Human Resources Development—Youth Talent Support Program(PXM2018_014212_000043)North China University of Technology “YuYOU” Talent Training Program
文摘In this paper, three types of green spaces in Xijing Community in Shijingshan District of Beijing were selected for as the measuring points, the HOBO portable weather station was used to monitor the microclimate environmental changes in the same period and summarize the data of microclimate factors. The effectiveness of the simulation was verified by comparing the measured data with the simulated data obtained through ENVI-met. And strategies for microclimate adaptive design in residential areas were proposed according to the microclimate environmental characteristics of several green spaces.
