Objective: Lung cancer is one of the leading cancers and major causes of cancer mortality worldwide. The economic burden associated with the high mortality of lung cancer is high, which accounts for nearly $180 billio...Objective: Lung cancer is one of the leading cancers and major causes of cancer mortality worldwide. The economic burden associated with the high mortality of lung cancer is high, which accounts for nearly $180 billion on a global scale in 2008. This paper aims to understand the economic burden of lung cancer in terms of disability adjusted life years(DALY) in Australia, the Philippines, and Singapore.Methods: The years of life lost(YLL) and years lost due to disability(YLD) were calculated using the formula developed by Murray and Lopez in 1996 as part of a comprehensive assessment of mortality and disability for diseases, injuries and risk factors in 1990 and projected to 2020. The same formula is represented in the Global Burden of Disease template provided by the World Health Organization. Appropriate assumptions were made when data were unavailable and projections were performed using regression analysis to obtain data for 2015.Results: The total DALYs due to lung cancer in Australia, the Philippines, and Singapore were 91,695, 38,584, and 12,435,respectively, and the corresponding DALY rates per a population of 1,000 were 4.0, 0.4, and 2.2, respectively, with a discount rate of 3%. When researchers calculated DALYs without the discount rate, the burden of disease increased substantially; the DALYs were 117,438 in Australia, 50,977 in the Philippines, and 16,379 in Singapore. Overall, YLL or premature death accounted for more than 95% of DALYs in these countries.Conclusions: Strategies for prevention, early diagnosis, and prompt treatment must be devised for diseases where the major burden is due to mortality.展开更多
Objective To analyze the prevalence and years lived with disability （YLD） from dental caries among children and adolescents and the time trends over the past two decades in Sichuan province, the largest province in ...Objective To analyze the prevalence and years lived with disability （YLD） from dental caries among children and adolescents and the time trends over the past two decades in Sichuan province, the largest province in west China. Methods Based on the Global Burden of Disease Study 2015 （GBD2015）, which systematically assessed the epidemiological characteristics of major diseases and their transitions by country and region from 1990 to 2015, we extracted the estimated results for China. We then used the Bayesian meta-regression method to estimate the sex- and age-specific prevalences and YLDs from dental caries among children and adolescents under 15 years old in Sichuan province and compared them with global and national indicators for the same period. Results In 2015, there were almost 6 million cases of dental caries in children and adolescents （aged 〈 15 years） in Sichuan province, accounting for 6% of the total cases in China. For children under 5 years, the prevalence of deciduous caries was 55.9%, and the YLDs value was 10.8 per 100,000, while it was 24.3% and 5.1 per 100,000 respectively among 5- to 14-year-olds; for those aged 5 to 14 years, the prevalence of permanent caries was 21.5%, and the YLDs value was 11.5 per 100,000. From 1990 to 2015, the prevalence of dental caries for children under 5 years increased substantially, by 16.2%, and the YLDs increased by 8.7%. Among those aged 5 to 14 years, the prevalence increased and the YLDs decreased. Conclusion Dental caries remains a huge health burden in Western China. In contrast to the global and national data, the trend has increased rapidly over the past 25 years in this region. This work provides suggestions for the prevention and control for oral health in China with the policy of two-child.展开更多
The hydration products and microstructure of class G oil well cement and a newly developed plugging agent （YLD） slurries cured in the simulated temperature and pressure environment, which was of similar temperature ...The hydration products and microstructure of class G oil well cement and a newly developed plugging agent （YLD） slurries cured in the simulated temperature and pressure environment, which was of similar temperature and pressure with those at the bottom of oil well in a normal depth, were investigated using XRD, TG and SEM. Severe leakage is confirmed at the interface between hardened slurries and steel tube during the dynamically curing process, which induces the quick loss of cementing property of slurries. This should be the dominating cause of degradation of class G oil well cement slurry. A secondary hydration process can take place at the eroded interface of hardened YLD plugging agent slurry. Newly formed C-S-H gel has a self-healing effect to repair the damaged interface, which unceasingly maintains the cementing property of the YLD plugging agent slurry. Therefore, the effective using period of YLD plugging agent can be prolonged.展开更多
Introduction: People with diabetes often develop diverse microvascular, macrovascular, and neuropathic complications. Diabetes named high disease because of its high prevalence, high incidence, chronicity and high cos...Introduction: People with diabetes often develop diverse microvascular, macrovascular, and neuropathic complications. Diabetes named high disease because of its high prevalence, high incidence, chronicity and high costs. Accurate projections of diabetes burden are essential for health planning so the aim of this study was to calculate the burden of diabetes in Razavikhorasan population, in Iran. Methodology: We used Disability Adjusted Life Years (DALYs) index using computer model (DisMod) for assessment of burden of diabetes and complications in Razavikhorasan province in Iran in year 2010-2011. Results: Burden of diabetes in Razavikhorasan population was 64,733 DALY in year 2010-2011. The total Years Life Lost (YLL) from diabetes mellitus was 62,883 (34,216 in men and 28,667 in women) due to premature death and the total Years Life Disability (YLD) was 1850. Conclusion: Diabetes mellitus and lesser forms of glucose intolerance can now be found in almost every population and epidemiological evidences suggest that, without effective prevention and control programs, diabetes will continue to increase and therefore advances in all levels of prevention may help reduce the number of people with diabetes.展开更多
目的基于全球疾病负担(global burden of disease,GBD)研究,对比日本、印度、美国、英国和全球,分析中国屈光不正疾病负担现状及变化趋势。方法从全球健康交流数据库获取1990—2019年屈光不正的患病率、伤残损伤寿命年(years lived with...目的基于全球疾病负担(global burden of disease,GBD)研究,对比日本、印度、美国、英国和全球,分析中国屈光不正疾病负担现状及变化趋势。方法从全球健康交流数据库获取1990—2019年屈光不正的患病率、伤残损伤寿命年(years lived with disability,YLD)率等指标,利用Joinpoint等软件分析屈光不正的疾病负担及变化趋势。结果2019年中国屈光不正人数超过2700万,患病率和YLD率分别为19.18‰和89.40/10万。1990—2019年,全球范围内屈光不正患病率和YLD率均呈增长趋势(印度除外),中国增幅最大(分别上升53.21%、53.96%)。中国、日本、美国和英国年龄标化YLD率均低于全球平均水平,但中国的年龄标化YLD率高于发达国家(日本、美国和英国)。结论1990—2019年,中国屈光不正的控制与发达国家有一定差距,仍需以全球角度了解疾病现状,以期更好的防控屈光不正。展开更多
In the context of the continuous growth of the aging population,priority has been given to the health promotion strategy of"orientation toward prevention and reduction of disease occurrence."On the basis of ...In the context of the continuous growth of the aging population,priority has been given to the health promotion strategy of"orientation toward prevention and reduction of disease occurrence."On the basis of the assessment of disability weights in the Global Burden of Disease(GBD),we assigned disability weights to the data on health conditions in the China Health and Retirement Longitudinal Study(CHARLS),using Years Lived with Disability(YLDs)as a quantitative indicator to evaluate the predictive effect of early psychosocial risks on health in old age.The results show that early psychosocial risks significantly increase YLDs in old age and have significant predictive power for high-risk health conditions among the elderly,and that the relationship between the two is causal.In addition,the study identifies four early psychosocial risks that lead to serious deterioration of the quality of life in old age:physical violence,childhood migration,maternal mental health and paternal physical health.These findings have significant implications for preventing the occurrence of aging diseases derived from the distal period of the individual’s lifetime and for implementing"full life cycle health management."展开更多
This paper focused on the effect of pre-strain on forming limit curves(FLC)of 5754-O aluminum alloy sheet through utilizing biaxial tensile approach.Based on Swift model and Yld2000-2 d yield criterion,the dimensions ...This paper focused on the effect of pre-strain on forming limit curves(FLC)of 5754-O aluminum alloy sheet through utilizing biaxial tensile approach.Based on Swift model and Yld2000-2 d yield criterion,the dimensions of cruciform specimen was optimized through applying finite element method for increasing the strain at specimen center.After that,with the recommended specimen size,the cruciform specimen was tested under various stroke ratios to experimentally characterize the limit strains under different pre-strain levels.Subsequently,the biaxial tensile tests were simulated by Abaqus to obtain the limit strains and validate the material models.It can be observed in both experiments and simulations that the pre-strained uniaxial tension followed by plane tension or equi-biaxial tension can improve the formability of sheet metals.Besides,the strain path change affects the trend of first derivative of strain rate difference between neighboring points with respect to time.An early increase occurred and then fell back to the stable value,the steady evolution continued until to a new increase reaching the critical value.The M–K prediction approach was simulated to verify the influence of pre-strain on FLC.It can be found that the early increase peaks of the major strain incremental ratio rose with the amplitude of pre-strain.Finally,the phenomenon of pseudolocalization caused by the strain path change was explained through evolution of stress state inside the groove.展开更多
The biaxial tensile tests were carried out to investigate the deformation behavior and yield loci of dual-phase （DP） steel sheets under biaxial tensile conditions. The true stress-true strain curves of DP steel shee...The biaxial tensile tests were carried out to investigate the deformation behavior and yield loci of dual-phase （DP） steel sheets under biaxial tensile conditions. The true stress-true strain curves of DP steel sheets for different loading ratios were obtained, and the experimental yield loci were determined based on the equivalent plastic work principle. The experimental yield loci were compared to the theoretical yield loci based on Hi1148, Hi1190, Hi1193, Hosford, Barlat89, Yld2000-2d and Gotoh yield criteria. It is found that Yld2000-2d yield criterion can describe the general trends of experimental yield loci of DP steel sheets with comparably higher accuracy. Hosford criterion has the maximum error for DP590, whereas Hi1148 and Barlat89 have the maximum errors for DP780 and DP980.展开更多
文摘Objective: Lung cancer is one of the leading cancers and major causes of cancer mortality worldwide. The economic burden associated with the high mortality of lung cancer is high, which accounts for nearly $180 billion on a global scale in 2008. This paper aims to understand the economic burden of lung cancer in terms of disability adjusted life years(DALY) in Australia, the Philippines, and Singapore.Methods: The years of life lost(YLL) and years lost due to disability(YLD) were calculated using the formula developed by Murray and Lopez in 1996 as part of a comprehensive assessment of mortality and disability for diseases, injuries and risk factors in 1990 and projected to 2020. The same formula is represented in the Global Burden of Disease template provided by the World Health Organization. Appropriate assumptions were made when data were unavailable and projections were performed using regression analysis to obtain data for 2015.Results: The total DALYs due to lung cancer in Australia, the Philippines, and Singapore were 91,695, 38,584, and 12,435,respectively, and the corresponding DALY rates per a population of 1,000 were 4.0, 0.4, and 2.2, respectively, with a discount rate of 3%. When researchers calculated DALYs without the discount rate, the burden of disease increased substantially; the DALYs were 117,438 in Australia, 50,977 in the Philippines, and 16,379 in Singapore. Overall, YLL or premature death accounted for more than 95% of DALYs in these countries.Conclusions: Strategies for prevention, early diagnosis, and prompt treatment must be devised for diseases where the major burden is due to mortality.
文摘Objective To analyze the prevalence and years lived with disability （YLD） from dental caries among children and adolescents and the time trends over the past two decades in Sichuan province, the largest province in west China. Methods Based on the Global Burden of Disease Study 2015 （GBD2015）, which systematically assessed the epidemiological characteristics of major diseases and their transitions by country and region from 1990 to 2015, we extracted the estimated results for China. We then used the Bayesian meta-regression method to estimate the sex- and age-specific prevalences and YLDs from dental caries among children and adolescents under 15 years old in Sichuan province and compared them with global and national indicators for the same period. Results In 2015, there were almost 6 million cases of dental caries in children and adolescents （aged 〈 15 years） in Sichuan province, accounting for 6% of the total cases in China. For children under 5 years, the prevalence of deciduous caries was 55.9%, and the YLDs value was 10.8 per 100,000, while it was 24.3% and 5.1 per 100,000 respectively among 5- to 14-year-olds; for those aged 5 to 14 years, the prevalence of permanent caries was 21.5%, and the YLDs value was 11.5 per 100,000. From 1990 to 2015, the prevalence of dental caries for children under 5 years increased substantially, by 16.2%, and the YLDs increased by 8.7%. Among those aged 5 to 14 years, the prevalence increased and the YLDs decreased. Conclusion Dental caries remains a huge health burden in Western China. In contrast to the global and national data, the trend has increased rapidly over the past 25 years in this region. This work provides suggestions for the prevention and control for oral health in China with the policy of two-child.
文摘The hydration products and microstructure of class G oil well cement and a newly developed plugging agent （YLD） slurries cured in the simulated temperature and pressure environment, which was of similar temperature and pressure with those at the bottom of oil well in a normal depth, were investigated using XRD, TG and SEM. Severe leakage is confirmed at the interface between hardened slurries and steel tube during the dynamically curing process, which induces the quick loss of cementing property of slurries. This should be the dominating cause of degradation of class G oil well cement slurry. A secondary hydration process can take place at the eroded interface of hardened YLD plugging agent slurry. Newly formed C-S-H gel has a self-healing effect to repair the damaged interface, which unceasingly maintains the cementing property of the YLD plugging agent slurry. Therefore, the effective using period of YLD plugging agent can be prolonged.
文摘Introduction: People with diabetes often develop diverse microvascular, macrovascular, and neuropathic complications. Diabetes named high disease because of its high prevalence, high incidence, chronicity and high costs. Accurate projections of diabetes burden are essential for health planning so the aim of this study was to calculate the burden of diabetes in Razavikhorasan population, in Iran. Methodology: We used Disability Adjusted Life Years (DALYs) index using computer model (DisMod) for assessment of burden of diabetes and complications in Razavikhorasan province in Iran in year 2010-2011. Results: Burden of diabetes in Razavikhorasan population was 64,733 DALY in year 2010-2011. The total Years Life Lost (YLL) from diabetes mellitus was 62,883 (34,216 in men and 28,667 in women) due to premature death and the total Years Life Disability (YLD) was 1850. Conclusion: Diabetes mellitus and lesser forms of glucose intolerance can now be found in almost every population and epidemiological evidences suggest that, without effective prevention and control programs, diabetes will continue to increase and therefore advances in all levels of prevention may help reduce the number of people with diabetes.
文摘目的基于全球疾病负担(global burden of disease,GBD)研究,对比日本、印度、美国、英国和全球,分析中国屈光不正疾病负担现状及变化趋势。方法从全球健康交流数据库获取1990—2019年屈光不正的患病率、伤残损伤寿命年(years lived with disability,YLD)率等指标,利用Joinpoint等软件分析屈光不正的疾病负担及变化趋势。结果2019年中国屈光不正人数超过2700万,患病率和YLD率分别为19.18‰和89.40/10万。1990—2019年,全球范围内屈光不正患病率和YLD率均呈增长趋势(印度除外),中国增幅最大(分别上升53.21%、53.96%)。中国、日本、美国和英国年龄标化YLD率均低于全球平均水平,但中国的年龄标化YLD率高于发达国家(日本、美国和英国)。结论1990—2019年,中国屈光不正的控制与发达国家有一定差距,仍需以全球角度了解疾病现状,以期更好的防控屈光不正。
基金the National Social Science Fund key project“Research on Progress in Contemporary Western Cultural Identity Theory”(18ASH008)。
文摘In the context of the continuous growth of the aging population,priority has been given to the health promotion strategy of"orientation toward prevention and reduction of disease occurrence."On the basis of the assessment of disability weights in the Global Burden of Disease(GBD),we assigned disability weights to the data on health conditions in the China Health and Retirement Longitudinal Study(CHARLS),using Years Lived with Disability(YLDs)as a quantitative indicator to evaluate the predictive effect of early psychosocial risks on health in old age.The results show that early psychosocial risks significantly increase YLDs in old age and have significant predictive power for high-risk health conditions among the elderly,and that the relationship between the two is causal.In addition,the study identifies four early psychosocial risks that lead to serious deterioration of the quality of life in old age:physical violence,childhood migration,maternal mental health and paternal physical health.These findings have significant implications for preventing the occurrence of aging diseases derived from the distal period of the individual’s lifetime and for implementing"full life cycle health management."
基金supported by the National Natural Science Foundation of China(Grant No.51875027)the China Postdoctoral Science Foundation(No.2018M630058)assistances of the program for the financial support。
文摘This paper focused on the effect of pre-strain on forming limit curves(FLC)of 5754-O aluminum alloy sheet through utilizing biaxial tensile approach.Based on Swift model and Yld2000-2 d yield criterion,the dimensions of cruciform specimen was optimized through applying finite element method for increasing the strain at specimen center.After that,with the recommended specimen size,the cruciform specimen was tested under various stroke ratios to experimentally characterize the limit strains under different pre-strain levels.Subsequently,the biaxial tensile tests were simulated by Abaqus to obtain the limit strains and validate the material models.It can be observed in both experiments and simulations that the pre-strained uniaxial tension followed by plane tension or equi-biaxial tension can improve the formability of sheet metals.Besides,the strain path change affects the trend of first derivative of strain rate difference between neighboring points with respect to time.An early increase occurred and then fell back to the stable value,the steady evolution continued until to a new increase reaching the critical value.The M–K prediction approach was simulated to verify the influence of pre-strain on FLC.It can be found that the early increase peaks of the major strain incremental ratio rose with the amplitude of pre-strain.Finally,the phenomenon of pseudolocalization caused by the strain path change was explained through evolution of stress state inside the groove.
基金This research was funded by National Natural Science Foundation of China （51275026） and State Key Laboratory of Development and Application Technology of Automotive Steels （Bao Steel Y 12ECEQ07Y）.
文摘The biaxial tensile tests were carried out to investigate the deformation behavior and yield loci of dual-phase （DP） steel sheets under biaxial tensile conditions. The true stress-true strain curves of DP steel sheets for different loading ratios were obtained, and the experimental yield loci were determined based on the equivalent plastic work principle. The experimental yield loci were compared to the theoretical yield loci based on Hi1148, Hi1190, Hi1193, Hosford, Barlat89, Yld2000-2d and Gotoh yield criteria. It is found that Yld2000-2d yield criterion can describe the general trends of experimental yield loci of DP steel sheets with comparably higher accuracy. Hosford criterion has the maximum error for DP590, whereas Hi1148 and Barlat89 have the maximum errors for DP780 and DP980.
