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A study on the treatment of chloasma with moxibustion based on the theory of“Yang transforming Qi,and Yin shaping”
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作者 Mi Yang Hong-Yi Lan +2 位作者 Hong Wu Xu Wang Xin-Ju Li 《Clinical Research Communications》 2024年第3期23-28,共6页
Background:“Yang Transforming Qi and Yin shaping”comes from“Plain Question Yin and Yang should be like the theory”.Chinese medicine believes that the imbalance of yin and yang is the cause of human diseases.One of... Background:“Yang Transforming Qi and Yin shaping”comes from“Plain Question Yin and Yang should be like the theory”.Chinese medicine believes that the imbalance of yin and yang is the cause of human diseases.One of the strengths of TCM in treating diseases is holistic regulation.The theory of“Yang transforming Qi,and Yin shaping”implies a strong holistic view.Chloasma,one of the common skin diseases,seriously affects the physical and mental health of patients due to its unclear etiology,difficult treatment and easy recurrence.The occurrence and development of chloasma are closely related to internal organs.This paper is based on the theory of internal meridian,“Yang transforming Qi,and Yin shaping”which attaches importance to the concept of“Yang Qi”,from a new understanding of the pathogenesis etiology of chloasma.Methods:The author believes that the incidence of the disease is the deficiency of Yang Qi,which can’t promote the movement of Qi and blood to nourish the face,resulting in tangible material condensation,so proposes that this disease needs to be promoted by Yang transforming Qi and warm to dissipate.Moxibustion belongs to the fire,and its warming effect can dissipate the tangible evil.Results:Combined with clinical practice and the theory of internal meridian,the author elaborated that moxibustion is one of the effective methods for treating chloasma,which provides a new way of thinking for the treatment of chloasma.Conclusion:“Yang Transforming Qi and Yin shaping”can be used to guide the treatment of chloasma. 展开更多
关键词 yang Transforming Qi and yin shaping MOXIBUSTION CHLOASMA
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Differential Effects of Yin- and Yang-Chinese Tonifying Herbs on Innate and Adaptive Immunity
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作者 Hoi Yan Leung Kam Ming Ko 《Chinese Medicine》 2023年第2期68-78,共11页
The present study investigated the effect of treatment with methanolic extracts of Yin- and Yang-Chinese tonifying herbs on concanavalin A (Con A)/lipopolysaccharide (LPS)-stimulated splenocyte proliferation (adaptive... The present study investigated the effect of treatment with methanolic extracts of Yin- and Yang-Chinese tonifying herbs on concanavalin A (Con A)/lipopolysaccharide (LPS)-stimulated splenocyte proliferation (adaptive immunity) and natural killer (NK) cell activity (innate immunity) in an ex vivo mouse model. The results indicated that while treatment with most Yin herbal extracts potentiated the Con A/LPS-stimulated splenocyte proliferation, only Yang (but not Yin) herbal extracts stimulated NK cell activity. The differential effects of Yin- and Yang-Chinese tonifying herbs on innate and adaptive immunity are consistent with the Chinese medicine theory which depicts the Yin and Yang functional components of Zheng Qi (vital energy), with the Yang component being responsible for the first line of defense against invading microorganisms (i.e., innate immunity) and the Yin oner serving as a follow-up defensive response (adaptive immunity). 展开更多
关键词 yin yang Innate Immunity Adaptive Immunity Natural Killer Cell Activity Splenocyte Proliferation
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Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia: Yin and Yang 被引量:8
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作者 Hong-Sheng Zhou Bing Z.Carter Michael Andreeff 《Cancer Biology & Medicine》 SCIE CAS CSCD 2016年第2期248-259,共12页
Acute myeloid leukemia (AML) is characterized by the accumulation of circulating immature blasts that exhibit uncontrolled growth, lack the ability to undergo normal differentiation, and have decreased sensitivity t... Acute myeloid leukemia (AML) is characterized by the accumulation of circulating immature blasts that exhibit uncontrolled growth, lack the ability to undergo normal differentiation, and have decreased sensitivity to apoptosis. Accumulating evidence shows the bone marrow (BM) niche is critical to the maintenance and retention of hematopoietic stem cells (HSC), including leukemia stem cells (LSC), and an increasing number of studies have demonstrated that crosstalk between LSC and the stromal cells associated with this niche greatly influences leukemia initiation, progression, and response to therapy. Undeniably, stromal cells in the BM niche provide a sanctuary in which LSC can acquire a drug-resistant phenotype and thereby evade chemotherapy- induced death. Yin and Yang, the ancient Chinese philosophical concept, vividly portrays the intricate and dynamic interactions between LSC and the BM niche. In fact, LSC-induced microenvironmental reprogramming contributes significantly to leukemogenesis. Thus, identifying the critical signaling pathways involved in these interactions will contribute to target optimization and combinatorial drug treatment strategies to overcome acquired drug resistance and prevent relapse following therapy. In this review, we describe some of the critical signaling pathways mediating BM niche-LSC interaction, including SDFI/CXCL12, Wnt/β-catenin, VCAM/VLA-4/NF-κB, CD44, and hypoxia as a newly-recognized physical determinant of resistance, and outline therapeutic strategies for overcoming these resistance factors. 展开更多
关键词 Bone marrow niche leukemia stem cell acute myeloid leukemia yin and yang
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Molecular Yin and Yang of erectile function and dysfunction 被引量:1
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作者 Ching-Shwun Lin Zhong-Cheng Xin +2 位作者 Zhong Wang Guiting Lin Tom E Lue 《Asian Journal of Andrology》 SCIE CAS CSCD 2008年第3期433-440,共8页
In regard to erectile function, Yin is flaccidity and Yang erection. In the past decade, research has mostly focused on the Yang aspect of erectile function. However, in recent years, the Yin side is attracting increa... In regard to erectile function, Yin is flaccidity and Yang erection. In the past decade, research has mostly focused on the Yang aspect of erectile function. However, in recent years, the Yin side is attracting increasingly greater attention. This is due to the realization that penile flaccidity is no less important than penile erection and is actively maintained by mechanisms that play critical roles in certain types of erectile dysfunction (ED); for example, in diabetic patients. In addition, there is evidence that the Yin and Yang signaling pathways interact with each other during the transition from flaccidity to erection, and vice versa. As such, it is important that we view erectile function from not only the Yang but also the Yin side. The purpose of this article is to review recent advances in the understanding of the molecular mechanisms that regulate the Yin and Yang of the penis. Emphasis is given to the Rho kinase signaling pathway that regulates the Yin, and to the cyclic nucleotide signaling pathway that regulates the Yang. Discussion is organized in such a way so as to follow the signaling cascade, that is, beginning with the extracellular signaling molecules (e.g., norepinephrin and nitric oxide) and their receptors, converging onto the intracellular effectors (e.g., Rho kinase and protein kinase G), branching into secondary effectors, and finishing with contractile molecules and phosphodiesterases. Interactions between the Yin and Yang signaling pathways are discussed as well. 展开更多
关键词 erectile function erectile dysfunction molecular mechanisms Rho kinase signaling cyclic nucleotide signaling yin-yang
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Discussion on Reinforcing and Reducing Manipulation of Yin and Yang in Acupuncture
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作者 Zhang Changzhi(Cerebral Institute,52935 Unit of the PLA)Zhao Xhuancha Wang Junhong,(Outpatient Department,52935 Unit of the PLA) 《中国针灸》 CAS CSCD 北大核心 1995年第S2期351-352,共2页
DiscussiononReinforcingandReducingManipulationofYinandYanginAcupuncture¥ZhangChangzhi(CerebralInstitute,5293... DiscussiononReinforcingandReducingManipulationofYinandYanginAcupuncture¥ZhangChangzhi(CerebralInstitute,52935UnitofthePLA)Zha... 展开更多
关键词 ACUPUNCTURE DISCUSSION yin REDUCING Reinforcing yang MANIPULATION and of
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Facing stress and inflammation:From the cell to the planet
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作者 Jean-Marc Cavaillon Irshad H Chaudry 《World Journal of Experimental Medicine》 2024年第4期53-85,共33页
As identified in 1936 by Hans Selye,stress is shaping diseases through the induction of inflammation.But inflammation display some yin yang properties.On one hand inflammation is merging with the innate immune respons... As identified in 1936 by Hans Selye,stress is shaping diseases through the induction of inflammation.But inflammation display some yin yang properties.On one hand inflammation is merging with the innate immune response aimed to fight infectious or sterile insults,on the other hand inflammation favors chronic physical or psychological disorders.Nature has equipped the cells,the organs,and the individuals with mediators and mechanisms that allow them to deal with stress,and even a good stress(eustress)has been associated with homeostasis.Likewise,societies and the planet are exposed to stressful settings,but wars and global warming suggest that the regulatory mechanisms are poorly efficient.In this review we list some inducers of the physiological stress,psychologic stress,societal stress,and planetary stress,and mention some of the great number of parameters which affect and modulate the response to stress and render it different from an individual to another,from the cellular level to the societal one.The cell,the organ,the individual,the society,and the planet share many stressors of which the consequences are extremely interconnected ending in the domino effect and the butterfly effect. 展开更多
关键词 Climate change CYTOKINES Genetic diversity Global health Immunity Microplastics RESILIENCE yin yang
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Yin Yang: A New Perspective in Understanding the Development of Religion in Contemporary China
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作者 CHU YI, Lu 《Cultural and Religious Studies》 2014年第2期78-93,共16页
The Taoism on Yin Yang has influenced the Orientalists' perception concerning the types of relation among all existence in the universe for cenalries. It maintains that a society is comprised of countless antagonisti... The Taoism on Yin Yang has influenced the Orientalists' perception concerning the types of relation among all existence in the universe for cenalries. It maintains that a society is comprised of countless antagonistic components or conflicting social players, including religious institutions and the Chinese government. All existence is charged with two great forces, simply known as Yin and Yang. These two great forces are opposite-but-complementary to each other. They determine how social players interact to avoid chaos and destructions, so balance and harmony are established and maintained in society. In other words, Yin Yang helps the social players to form a harmonious relationship with one and another by weakening or strengthening their inner inherited Yin-or-Yang elements according to timing and conditions. Drawing on recent research on Yin Yang as a novel approach in understanding business-related issues in contemporary China, such concept is also relevant to understand the development of religion in China. 展开更多
关键词 RELIGION China TAOISM yin yang
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The Reality and Application of Yin and Yang
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作者 Wutong Song Hongxin Cao 《Chinese Medicine》 CAS 2022年第2期23-31,共9页
Ancient Chinese philosophers discovered Yin and Yang and the laws of Yin and Yang movement during their exploration and practice of nature more than two thousand years ago, and applied them to life, science, philosoph... Ancient Chinese philosophers discovered Yin and Yang and the laws of Yin and Yang movement during their exploration and practice of nature more than two thousand years ago, and applied them to life, science, philosophy and medicine, playing an important role in the achievement of ancient Chinese civilization. Through historical changes, yin and yang have gradually been regarded as a concept or theory, thus making it difficult for people to understand the connotation of Yin-Yang and make new discoveries and progress. Nowadays, many scholars in China and the West are interested in studying the treasures of ancient Chinese civilization. We illustrate the actual function of Yin and Yang by explaining the essential state of matter, the law of physical movement, the transformation of energy, and then illustrate the practical application in life and science. In conclusion, yin-yang is a key to unlocking the treasures of traditional Chinese civilization, which can help to bring into play its original values, and continue to provide new insights and directions for the development of modern science and the advancement of humanities. 展开更多
关键词 yin and yang Material Properties Physical Movement Energy Transformation Practical Applications
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Uncovering the Messages Behind Four Imperial Dragon Robes from Exhibitions With Yin and Yang Message
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作者 Shu Hwa Lin C J Duarte 《Journalism and Mass Communication》 2017年第1期53-62,共10页
The design themes of three Qing dynasty imperial dragon robes from the University of Hawaii at Manoa Costume Collection act as carriers of the Chinese yin-yang philosophy. The information shared by these imperial drag... The design themes of three Qing dynasty imperial dragon robes from the University of Hawaii at Manoa Costume Collection act as carriers of the Chinese yin-yang philosophy. The information shared by these imperial dragon robes are discussed through a cultural and technological analysis of the symbolic motifs and fabric structures of these garments to reveal the cultural and social impact ofyin-yang on Qing imperial costume design. 展开更多
关键词 Dragon robe yin and yang imperial/court costume
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Research on Sports Health System from the perspective of Yin-Yang and Balance
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作者 Jiaqi Kou 《International Journal of Technology Management》 2017年第1期35-37,共3页
Traditional sports health is an integral part of Chinese culture, Chinese civilization is accompanied by a process to produce, to grow up. It has self-cultivation, physical ? tness and longevity effect. Unfortunately... Traditional sports health is an integral part of Chinese culture, Chinese civilization is accompanied by a process to produce, to grow up. It has self-cultivation, physical ? tness and longevity effect. Unfortunately, despite thousands of years of traditional sports health practice, the formation of a rich health ideas, but these traditional sports health mind, like scattered pearls scattered in the literature and practice of traditional sports health, without to pick up a bunch of dressed form traditional sports regimen thought a monograph system. Based on this, the present study the history of ideas as a starting point for a study of traditional sports and health aspects of the history of ideas, aimed at the formation of traditional sports and health history of ideas monographs, traditional sports for the rich theory of health and promote the further development of traditional sports health theoretical system of scientific value. We life philosophy, yin and yang sports concept of yin and yang as the number concept of yin and yang concept of information four angles, analyzes the theory of Yin and Yang. 展开更多
关键词 yin and yang balance perspective HEALTH sports system ANALYTIC
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Research on the Flexible Yoga Training Mode based on Yin and Yang Theory of Dialectical Thinking Pattern
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作者 Xueyan Li 《International Journal of Technology Management》 2015年第11期55-57,共3页
In this research paper, we conduct research on the flexible yoga training mode based on Yin and Yang theory of dialectical thinking pattern. Yoga become modem young people are increasingly keen on sports exercise prog... In this research paper, we conduct research on the flexible yoga training mode based on Yin and Yang theory of dialectical thinking pattern. Yoga become modem young people are increasingly keen on sports exercise program, at the same time, as more ferocious originated in India yoga culture, even beyond the native of the popularity of the tai chi culture in China, in view of this kind of social cultural phenomenon, the author think it is necessary to carry out the two of fitness culture contrast research, to more deep understanding from angle of culturology of tai chi chuan and the Indian yoga in development in our country, as well as the similarities and differences of inheritance, development and research of its better to provide theoretical reference. We discuss the combination of the cutures and propose the flexible yoga training mode which is innovative. 展开更多
关键词 Yoga Training yin and yang Dialectical Thinking Pattern Flexible Yoga.
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Differential Effects of Ursolic Acid and Oleanolic Acid on Mitochondrial ATP Generation in H9c2 Cardiomyocytes and Lipopolysaccharide-Induced Cell Proliferation in Mouse Splenocytes: Yang versus Yin
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作者 Hoi Yan Leung Kai Chit Cheung Kam Ming Ko 《Chinese Medicine》 2021年第3期37-46,共10页
<span style="font-family:Verdana;">In the present study, two cell-based systems for assessing Yang and Yin activities were for the first time used to investigate the effect of ursolic acid (UA) and ole... <span style="font-family:Verdana;">In the present study, two cell-based systems for assessing Yang and Yin activities were for the first time used to investigate the effect of ursolic acid (UA) and oleanolic acid (OA). The results indicated that while UA was only active in the Yang assay, OA produced activity in the Yin assay. The Yang/Yin activity of UA/OA may be attributed to their distinct molecular structures, which confer their differential ability to interact with mitochondrial membrane or cellular membrane lipids, with resultant membrane fluidization and potentiation of biological responses.</span> 展开更多
关键词 yang yin Ursolic Acid Oleanolic Acid Mitochondrial ATP Generation SPLENOCYTES
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Acupuncture Treating Heart Diseases Based on Sixty JiaZi and Eight Palaces <br/>—Mathematical Reasoning of Treatment Principle Based on Yin Yang Wu Xing Theory in Traditional Chinese Medicine (V)
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作者 Yingshan Zhang Yan Li Chunyun Guo 《Chinese Medicine》 2021年第3期118-184,共67页
<span style="font-family:Verdana;">Theory</span><span style="font-family:Verdana;" "=""> of Sixty JiaZi (60 </span><span style="font-family:Verdana;&q... <span style="font-family:Verdana;">Theory</span><span style="font-family:Verdana;" "=""> of Sixty JiaZi (60 </span><span style="font-family:Verdana;">甲子</span><span style="font-family:;" "=""><span style="font-family:Verdana;">) is useful in understanding a human body disease. By using mathematical reasoning based on Yin Yang Wu Xing Theory in Traditional Chinese Medicine (TCM), this paper demonstrates the treatment principle: “seize the momentum of development, hasten </span><span style="font-family:Verdana;">lucky</span> <span style="font-family:Verdana;">avoids</span><span style="font-family:Verdana;"> disaster” (</span></span><span style="font-family:Verdana;">顺势而为</span><span style="font-family:Verdana;" "="">, </span><span style="font-family:Verdana;">趋吉避凶</span><span style="font-family:;" "=""><span style="font-family:Verdana;">). Sixty </span><span style="font-family:Verdana;">JiaZi</span><span style="font-family:Verdana;"> is hidden behind eight palaces. The first or second transfer law of human body energies of Sixty JiaZi changes according to the different blood pH values of a human body whether in the normal range or not, respectively, assuming that the range of blood pH values of a human </span><span style="font-family:Verdana;">body</span><span style="font-family:Verdana;"> is divided into four parts from small to large. Both second and third are for a healthy human body. Both the </span><span style="font-family:Verdana;">root-cause</span><span style="font-family:Verdana;"> and symptoms come from the first transfer law of human body energies. And both first and fourth are for an unhealthy human body. Both the </span><span style="font-family:Verdana;">root-cause</span><span style="font-family:Verdana;"> and symptoms come from the second transfer law of human body energies. The treating disease of a human body should protect and maintain the balance of two incompatibility relations: the loving relationship and the killing relationship. As an application, acupuncture is used to treat atrial premature beats as congenital heart disease.</span></span> 展开更多
关键词 Traditional Chinese Medicine (TCM) yin yang Wu Xing Theory Steady Multilateral Systems Incompatibility Relations Side Effects Medical and Drug Resistance Problem
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Assessment of Ankylosing Spondylitis Based on the Theory of Yin and Yang in Traditional Chinese Medicine
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作者 Yuan Cheng Jichao Yin +3 位作者 Xinglv Hu Penggang Xu Yingchun Liu Chengxiang Lei 《Journal of Clinical and Nursing Research》 2021年第5期33-36,共4页
The theory of yin and yang in Chinese medicine signifies everything and can be used to divide everything in the world.The diagnosis and assessment of ankylosing spondylitis in Western medicine can also be divided by y... The theory of yin and yang in Chinese medicine signifies everything and can be used to divide everything in the world.The diagnosis and assessment of ankylosing spondylitis in Western medicine can also be divided by yin and yang.The current technologies used in Western medicine for detecting ankylosing spondylitis is summarized,divided,and reasoned with the philosophical views of yin and yang in traditional Chinese medicine. 展开更多
关键词 Traditional Chinese medicine Ankylosing spondylitis yin and yang theory
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On the Possible Structures of Electron and Proton
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作者 Wei-Xing Xu 《Journal of High Energy Physics, Gravitation and Cosmology》 CAS 2024年第4期1734-1742,共9页
In this work, the possible structures of electron and proton have been explored. Based on the potential expressions of electron and proton, we found that the electron and proton share the similar structure inside re a... In this work, the possible structures of electron and proton have been explored. Based on the potential expressions of electron and proton, we found that the electron and proton share the similar structure inside re and rn. And within re and rn, the conventional charge concept stops working, the same charge repelling force doesn’t exist anymore and as a result, the requirement of charge conservation is automatically removed. Whereas beyond re and rn, the potential expressions of electron and proton obey the point charge potentials as we normally understand. Therefore, the conventional charge concept can be applied and the requirement of charge conservation takes effect. Furthermore, a possible mechanism for the creations of electric monopole and magnetic monopole is discussed. In addition, to compare the particle size in micro-world, the balloon criterion is proposed. By this balloon criterion, the proton is determined about 10 times bigger than electron. From the physical picture about electron and proton described above, the stabilities of electron and proton can be explained quite well. 展开更多
关键词 Electromagnetic Spacetime Quantum Mechanics ELECTRON PROTON Standard Model Particle Physics yin-yang Philosophy Electric Monopole Magnetic Monopole Charge Conservation
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Discussion on the Application of Warm Yang to Promote Qi Transformation in Acne Mastitis from“Yang Promotes Qi Transformation and Yin Promotes Forming”
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作者 Yupei Chen Zhenlin Chen Pu Zhang 《Journal of Clinical and Nursing Research》 2021年第6期155-158,共4页
“Yang promotes Qi transformation and Yin promotes forming”maintains the normal progress of human life activities,which is an important embodiment of human vitality.The dysfunction of“Yang promotes Qi transformation... “Yang promotes Qi transformation and Yin promotes forming”maintains the normal progress of human life activities,which is an important embodiment of human vitality.The dysfunction of“Yang promotes Qi transformation and Yin promotes forming”leads to the coagulation of pathological products such as phlegm and blood stasis in the breast meridian,resulting in the occurrence of acne mastitis.In clinical treatment,we should take“warm Yang to promote Qi transformation”as the treatment principle,and add or subtract according to the specific situation. 展开更多
关键词 yang promotes Qi transformation and yin promotes formation Warm yang to promote Qi transformation Acne mastitis
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Therapy of Suppressing Yang and Astringing Yin for the Treatment of Cancer-Related Insomnia
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作者 Ranpei Zhu Xu Sun Yuling Zheng 《Chinese Medicine and Natural Products》 2022年第1期11-18,共8页
The pathogenesis of can cer-related in som nia(CRI)mainly in eludes,first,the flow of cancerous toxin leading to the disorder of visceral qi;second,cancer-related radiotherapy and chemotherapy belonging to"exogen... The pathogenesis of can cer-related in som nia(CRI)mainly in eludes,first,the flow of cancerous toxin leading to the disorder of visceral qi;second,cancer-related radiotherapy and chemotherapy belonging to"exogenous pathogenic factors"to a certain extent,which can further aggravate visceral disorders.The therapeutic principle of Chinese medicine is to tranquilize the mind on the basis of regulating viscera,suppressing yang,and astringing yin.On this theoretical basis,Professor Zheng Yuling created a representative prescription of Zhenjing Anshen Granules(镇静安神颗粒)which can achieve the co-regulation of the heart,liver,and kidney,tranquilizing the mind and nourishing the blood.Clinically,the selection of prescriptions and medicines needs to be considered due to factors such as different treatment stages and differ-ences in patients'constitutions. 展开更多
关键词 cancer related insomnia(CRI) suppressing yang and astringing yin Zhenjing Anshen Granules syndrome differentiation and treatment Yuling Zheng
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Image Mathematics—Mathematical Intervening Principle Based on “Yin Yang Wu Xing” Theory in Traditional Chinese Mathematics (I) 被引量:28
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作者 Yingshan Zhang Weilan Shao 《Applied Mathematics》 2012年第6期617-636,共20页
By using mathematical reasoning, this paper demonstrates the mathematical intervening principle: “Virtual disease is to fill his mother but real disease is to rush down his son” (虚则补其母, 实则泄其子) and “Strong... By using mathematical reasoning, this paper demonstrates the mathematical intervening principle: “Virtual disease is to fill his mother but real disease is to rush down his son” (虚则补其母, 实则泄其子) and “Strong inhibition of the same time, support the weak” (抑强扶弱) based on “Yin Yang Wu Xing” Theory in image mathematics of Traditional Chinese Mathematics (TCMath). We defined generalized relations and generalized reasoning, introduced the concept of steady multilateral systems with two non-compatibility relations, and discussed its energy properties. Later based on the intervention principle in image mathematics of TCMath and treated the research object of the image mathematics as a steady multilateral system, it has been proved that the mathematical intervening principle is true. The kernel of this paper is the existence and reasoning of the non-compatibility relations in steady multilateral systems, and it accords with the oriental thinking model. 展开更多
关键词 Image MATHEMATICS yin yang WU Xing” Theory Steady Multilateral Systems Opposite Non-Compatibility Relations INTERVENTION RULE Self-Protection RULE MATHEMATICAL Side Effects Mathe-matical INTERVENTION Resistance Problem
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Transcriptional dysregulation in neurodegenerative diseases:who tipped the balance of Yin Yang 1 in the brain? 被引量:1
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作者 Zhefan Stephen Chen Ho Yin Edwin Chan 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第7期1148-1151,共4页
Yin Yang 1(YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types,including neurons.It controls neuronal differentiation,as well as neuronal specification and migration... Yin Yang 1(YY1) is a multi-functional transcription factor that regulates gene expression in a range of cell types,including neurons.It controls neuronal differentiation,as well as neuronal specification and migration during the development of the mammalian nervous system.Besides,YY1 also mediates the transcription of genes that are required for neuronal survival.An impairment of the transcriptional function of YY1 causes neuronal death.This review summarizes recent research findings that unveil the dysfunction of YY1 in multiple neurodegenerative disorders.The expression of disease proteins perturbs the function of YY1 via distinct molecular mechanisms,including recruitment to protein aggregates,protein degradation and aberrant nuclear/cytoplasmic shuttling.Understanding the pathogenic roles of YY1 will further broaden our knowledge of the disease mechanisms in distinct neurodegenerative disorders. 展开更多
关键词 Alzheimer’s disease amyotrophic lateral SCLEROSIS neurodegeneration PROTEIN aggregates recruitment PROTEIN degradation SUBCELLULAR localization TRANSCRIPTIONAL regulation yin yang 1
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Mathematical Reasoning of Treatment Principle Based on “Yin Yang Wu Xing” Theory in Traditional Chinese Medicine 被引量:5
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作者 Yingshan Zhang 《Chinese Medicine》 2011年第1期6-15,共10页
By using mathematical reasoning, this paper demonstrates the treatment principle: “Virtual disease is to fill his mother but real disease is to rush down his son” and “Strong inhibition of the same time, support th... By using mathematical reasoning, this paper demonstrates the treatment principle: “Virtual disease is to fill his mother but real disease is to rush down his son” and “Strong inhibition of the same time, support the weak” based on “Yin Yang Wu Xing” Theory in Traditional Chinese Medicine (TCM). We defined two kinds of opposite relations and one kind of equivalence relation, introduced the concept of steady multilateral systems with two non-compatibility relations, and discussed its energy properties. Later based on the treatment of TCM and treated the healthy body as a steady multilateral system, it has been proved that the treatment principle is true. The kernel of this paper is the existence and reasoning of the non-compatibility relations in steady multilateral systems, and it accords with the oriental thinking model. 展开更多
关键词 Traditional Chinese Medicine yin yang WU Xing” THEORY STEADY Multilateral Systems Opposite RELATIONS Side Effects Medical and Drug Resistance Problem
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