Objective:To investigate the active compounds,key targets and molecular mechanism of Qizhu Yuling Decoction in the treatment of esophageal carcinoma based on network pharmacology.Methods:The active compounds of Qizhu ...Objective:To investigate the active compounds,key targets and molecular mechanism of Qizhu Yuling Decoction in the treatment of esophageal carcinoma based on network pharmacology.Methods:The active compounds of Qizhu Yuling Decoction with anti-esophageal cancer activity were screened by TCMSP and literature search,and the drug targets were searched by DrugBank and predicted by SwissTargetPrediction.The esophageal cancer-related genes were obtained from GeneCards,OMIM,DrugBank,TTD,DisGeNET,and the intersection network was selected to obtain candidate genes.The"herb-compound-target-disease"network was constructed with Cytoscape,the PPI network was constructed in STRING and core network modules were screened.Gene ontology and KEGG enrichment analysis was performed by using Metascape,and the"pathway-gene"network was constructed to further screen key targets.Results:A total of 47 active compounds(19 Astragalus,4 Zedoary turmeric,11 Atractylodes macrocephala,9 Curcuma longa,5 Clematis root,and 5 Salvia chinensis),297 candidate genes,2413 GO and 119 KEGG pathways were obtained.Conclusion:The active compounds of Qizhu Yuling Decoction in the treatment of esophageal cancer are quercetin,kaempferol,glycine and ursolic acid.The potential targets are AKT1,MAPK1,MAPK3,PIK3R1 and RELA.GO involves oxidative stress,cell cycle,apoptosis and cell death,and KEGG involves typical cancer pathways,MAPK,NF-κB and PI3K-Akt signaling pathways.This study reveals the molecular biological mechanism of Qizhu Yuling Decoction in the treatment of esophageal cancer,and speculates that the function of potential targets focuses on the interaction of multiple signaling pathways,which can antagonize the proliferation,invasion,metastasis and recurrence of esophageal cancer and improve the prognosis of patients.This study provides new evidence for subsequent new drug development,clinical application and experimental study.展开更多
Objective:To analyze the medication rules of ZHENG Yuling in the treatment of cervical cancer,and provide a basis for the clinical practice of Chinese medicine for the treatment of cervical cancer.Methods:The data of ...Objective:To analyze the medication rules of ZHENG Yuling in the treatment of cervical cancer,and provide a basis for the clinical practice of Chinese medicine for the treatment of cervical cancer.Methods:The data of patients with cervical cancer treated by ZHENG Yuling in the First Hospital Affliated to Henan Univer-sity of Chinese Medicine from March 26,2017 to January 5,2021 were collected and the medication rules were analyzed.Results:Totally 143 cases were included,and the most frequently used prescriptions were Wuling Powder(五苓散),Simiao Powder(四妙散),Danggui Shaoyao Powder(当归芍药散),Shuyu Pill(薯损丸),Qingxin Lianzi Decoetion(清心莲子饮),Bazhen Decoction(八珍汤),etc.With statistics of the efficacy,all Chinese materia medica were divided into 19 categories,and their properties were mainly warm,mild and cold;the flavors of medicine were mainly sweet,pungent and bitter;the meridian tropism mainly ineludes the lung,liver,spleen and stomach.After cluster analysis and factor analysis,15 common factors were extracted;through the analysis of association rules,14 groups of Chinese materia medica combinations with high frequency associ-ation strength were obtai ned.Conclusion:ZHENG Yuling believes that the pathogenesis of cervical cancer is not only related to disorder between Chong and conception Channels due to the intermingling of dampness,tox-icity,blood stasis,and phlegm but also retention of urine due to qi stagnation and water retention.The direct disease location is in the uterus and indirect location may involve the lung,liver,spleen and kidney according to the development of disease,accompanying symptoms and the different constitutions of the patients.It is advo-cated that attention should be paid to not only removing dampness,detoxification,removing blood stasis,and re-ducing phlegm,but also regulating qi,opening the blockage,promoting water flow.At the same time,the spleen and stomach should be protected,and tonification and purgation should be applied in combination.展开更多
The Qi Yuling case is a crucial juncture in the study of “fundamental rights and private law” in China, yet relevant research is underpinned on two clues. The first is that the increasing interest in the “constitut...The Qi Yuling case is a crucial juncture in the study of “fundamental rights and private law” in China, yet relevant research is underpinned on two clues. The first is that the increasing interest in the “constitutionalization of private law” worldwide provides knowledge resources and reference materials for scholars in China;the second is the understanding and exploration of the judicial application of the Constitution since the 1980s. Among them, such concepts as “the Constitution has direct legal effect” and “the Constitution needs to be implemented by the people” could have directly affected the Qi Yuling case. Focusing on such topics as the case of Qi Yuling, judicial enforcement of the Constitution, and the compilation of the Civil Code, scholars discussed the ways and scope for inclu ding fundamental rights in private law based on their experience abroad. They also looked into specific issues, covering how fundamental rights affect civil acts and the private law effects fundamental rights like personality rights, equali ty rights, freedom of speech, and protection of personal information. In the context of promoting the full implementation of the Constitution in the new era, “fundamental rights and private law” is still a field with great potential in both practice and theory.展开更多
We discuss formulas and techniques for finding maximum-likelihood estimators of parameters of autoregressive (with particular emphasis on Markov and Yule) models, computing their asymptotic variance-covariance matrix ...We discuss formulas and techniques for finding maximum-likelihood estimators of parameters of autoregressive (with particular emphasis on Markov and Yule) models, computing their asymptotic variance-covariance matrix and displaying the resulting confidence regions;Monte Carlo simulation is then used to establish the accuracy of the corresponding level of confidence. The results indicate that a direct application of the Central Limit Theorem yields errors too large to be acceptable;instead, we recommend using a technique based directly on the natural logarithm of the likelihood function, verifying its substantially higher accuracy. Our study is then extended to the case of estimating only a subset of a model’s parameters, when the remaining ones (called nuisance) are of no interest to us.展开更多
The pathogenesis of can cer-related in som nia(CRI)mainly in eludes,first,the flow of cancerous toxin leading to the disorder of visceral qi;second,cancer-related radiotherapy and chemotherapy belonging to"exogen...The pathogenesis of can cer-related in som nia(CRI)mainly in eludes,first,the flow of cancerous toxin leading to the disorder of visceral qi;second,cancer-related radiotherapy and chemotherapy belonging to"exogenous pathogenic factors"to a certain extent,which can further aggravate visceral disorders.The therapeutic principle of Chinese medicine is to tranquilize the mind on the basis of regulating viscera,suppressing yang,and astringing yin.On this theoretical basis,Professor Zheng Yuling created a representative prescription of Zhenjing Anshen Granules(镇静安神颗粒)which can achieve the co-regulation of the heart,liver,and kidney,tranquilizing the mind and nourishing the blood.Clinically,the selection of prescriptions and medicines needs to be considered due to factors such as different treatment stages and differ-ences in patients'constitutions.展开更多
An algorithm for multivariable autoregressive moving average (MARMA) modelling which only uses scalar computations is proposed. The given MARMA process is converted to an equivalent scalar, periodic ARMA process. The ...An algorithm for multivariable autoregressive moving average (MARMA) modelling which only uses scalar computations is proposed. The given MARMA process is converted to an equivalent scalar, periodic ARMA process. The scalar autoregressive (AR) parameters展开更多
Spectral estimation method is an effective method in the case of parameter estimation of sinusoid signal in noises.It always applies cross spectral estimation theory and high order self spectral estimation methods up ...Spectral estimation method is an effective method in the case of parameter estimation of sinusoid signal in noises.It always applies cross spectral estimation theory and high order self spectral estimation methods up to now.Yule Walker equation based on cross fourth order cumulant is developed and Pisarenko method is provided in this paper.Simulation results show that the method is effective to retrieve sinusoid signal frequencies from hybrid colored noises and has good performance.展开更多
基金National Natural Science Foundation of China(No.81774289)Beijing Science and Technology Plan Major Fund Project(No.D161100005116004)China Academy of Chinese Medical Sciences(No.ZZ11-028)。
文摘Objective:To investigate the active compounds,key targets and molecular mechanism of Qizhu Yuling Decoction in the treatment of esophageal carcinoma based on network pharmacology.Methods:The active compounds of Qizhu Yuling Decoction with anti-esophageal cancer activity were screened by TCMSP and literature search,and the drug targets were searched by DrugBank and predicted by SwissTargetPrediction.The esophageal cancer-related genes were obtained from GeneCards,OMIM,DrugBank,TTD,DisGeNET,and the intersection network was selected to obtain candidate genes.The"herb-compound-target-disease"network was constructed with Cytoscape,the PPI network was constructed in STRING and core network modules were screened.Gene ontology and KEGG enrichment analysis was performed by using Metascape,and the"pathway-gene"network was constructed to further screen key targets.Results:A total of 47 active compounds(19 Astragalus,4 Zedoary turmeric,11 Atractylodes macrocephala,9 Curcuma longa,5 Clematis root,and 5 Salvia chinensis),297 candidate genes,2413 GO and 119 KEGG pathways were obtained.Conclusion:The active compounds of Qizhu Yuling Decoction in the treatment of esophageal cancer are quercetin,kaempferol,glycine and ursolic acid.The potential targets are AKT1,MAPK1,MAPK3,PIK3R1 and RELA.GO involves oxidative stress,cell cycle,apoptosis and cell death,and KEGG involves typical cancer pathways,MAPK,NF-κB and PI3K-Akt signaling pathways.This study reveals the molecular biological mechanism of Qizhu Yuling Decoction in the treatment of esophageal cancer,and speculates that the function of potential targets focuses on the interaction of multiple signaling pathways,which can antagonize the proliferation,invasion,metastasis and recurrence of esophageal cancer and improve the prognosis of patients.This study provides new evidence for subsequent new drug development,clinical application and experimental study.
基金We thank for the funding support from the "HundredThousandTen Thousand"Talents Project of Chinese Medicine Inheritance and Innovation(Qihuang Project)—Qihuang Scholars(284 official letter of People′s Education of Chinese Medicine 2018)as well as Special Scientific Research Project of National Clinical Research Base of Traditional Chinese Medicine(2019JDZX001).
文摘Objective:To analyze the medication rules of ZHENG Yuling in the treatment of cervical cancer,and provide a basis for the clinical practice of Chinese medicine for the treatment of cervical cancer.Methods:The data of patients with cervical cancer treated by ZHENG Yuling in the First Hospital Affliated to Henan Univer-sity of Chinese Medicine from March 26,2017 to January 5,2021 were collected and the medication rules were analyzed.Results:Totally 143 cases were included,and the most frequently used prescriptions were Wuling Powder(五苓散),Simiao Powder(四妙散),Danggui Shaoyao Powder(当归芍药散),Shuyu Pill(薯损丸),Qingxin Lianzi Decoetion(清心莲子饮),Bazhen Decoction(八珍汤),etc.With statistics of the efficacy,all Chinese materia medica were divided into 19 categories,and their properties were mainly warm,mild and cold;the flavors of medicine were mainly sweet,pungent and bitter;the meridian tropism mainly ineludes the lung,liver,spleen and stomach.After cluster analysis and factor analysis,15 common factors were extracted;through the analysis of association rules,14 groups of Chinese materia medica combinations with high frequency associ-ation strength were obtai ned.Conclusion:ZHENG Yuling believes that the pathogenesis of cervical cancer is not only related to disorder between Chong and conception Channels due to the intermingling of dampness,tox-icity,blood stasis,and phlegm but also retention of urine due to qi stagnation and water retention.The direct disease location is in the uterus and indirect location may involve the lung,liver,spleen and kidney according to the development of disease,accompanying symptoms and the different constitutions of the patients.It is advo-cated that attention should be paid to not only removing dampness,detoxification,removing blood stasis,and re-ducing phlegm,but also regulating qi,opening the blockage,promoting water flow.At the same time,the spleen and stomach should be protected,and tonification and purgation should be applied in combination.
文摘The Qi Yuling case is a crucial juncture in the study of “fundamental rights and private law” in China, yet relevant research is underpinned on two clues. The first is that the increasing interest in the “constitutionalization of private law” worldwide provides knowledge resources and reference materials for scholars in China;the second is the understanding and exploration of the judicial application of the Constitution since the 1980s. Among them, such concepts as “the Constitution has direct legal effect” and “the Constitution needs to be implemented by the people” could have directly affected the Qi Yuling case. Focusing on such topics as the case of Qi Yuling, judicial enforcement of the Constitution, and the compilation of the Civil Code, scholars discussed the ways and scope for inclu ding fundamental rights in private law based on their experience abroad. They also looked into specific issues, covering how fundamental rights affect civil acts and the private law effects fundamental rights like personality rights, equali ty rights, freedom of speech, and protection of personal information. In the context of promoting the full implementation of the Constitution in the new era, “fundamental rights and private law” is still a field with great potential in both practice and theory.
文摘We discuss formulas and techniques for finding maximum-likelihood estimators of parameters of autoregressive (with particular emphasis on Markov and Yule) models, computing their asymptotic variance-covariance matrix and displaying the resulting confidence regions;Monte Carlo simulation is then used to establish the accuracy of the corresponding level of confidence. The results indicate that a direct application of the Central Limit Theorem yields errors too large to be acceptable;instead, we recommend using a technique based directly on the natural logarithm of the likelihood function, verifying its substantially higher accuracy. Our study is then extended to the case of estimating only a subset of a model’s parameters, when the remaining ones (called nuisance) are of no interest to us.
基金supported by"Hundred-Thousand-Ten Thousand"Talents Project of Chinese Medicine Inheritance and Innovation(Qihuang Project)-Qihuang Scholars(284 Official Letter of People's Education of Chinese Medicine 2018)Special Scientific Research Project of National Clinical Research Base of Traditional Chinese Medicine(2019JDZX001)+2 种基金Special Scientific Research Project of National Clinical Research Base of Chinese Medicine(2019JDZX028)Key Scientific Research Project of Henan Province Colleges and Universities(20A360005)Henan Province Science and Technology Research and Social Development Project(202102310497).
文摘The pathogenesis of can cer-related in som nia(CRI)mainly in eludes,first,the flow of cancerous toxin leading to the disorder of visceral qi;second,cancer-related radiotherapy and chemotherapy belonging to"exogenous pathogenic factors"to a certain extent,which can further aggravate visceral disorders.The therapeutic principle of Chinese medicine is to tranquilize the mind on the basis of regulating viscera,suppressing yang,and astringing yin.On this theoretical basis,Professor Zheng Yuling created a representative prescription of Zhenjing Anshen Granules(镇静安神颗粒)which can achieve the co-regulation of the heart,liver,and kidney,tranquilizing the mind and nourishing the blood.Clinically,the selection of prescriptions and medicines needs to be considered due to factors such as different treatment stages and differ-ences in patients'constitutions.
文摘An algorithm for multivariable autoregressive moving average (MARMA) modelling which only uses scalar computations is proposed. The given MARMA process is converted to an equivalent scalar, periodic ARMA process. The scalar autoregressive (AR) parameters
文摘Spectral estimation method is an effective method in the case of parameter estimation of sinusoid signal in noises.It always applies cross spectral estimation theory and high order self spectral estimation methods up to now.Yule Walker equation based on cross fourth order cumulant is developed and Pisarenko method is provided in this paper.Simulation results show that the method is effective to retrieve sinusoid signal frequencies from hybrid colored noises and has good performance.
