Perilla frutescens L. is a traditional medicinal plant in china. In recent years, with more and more attention is paid to the nutritional and health values of Perilla frutescens L, it has become a potential medicinal ...Perilla frutescens L. is a traditional medicinal plant in china. In recent years, with more and more attention is paid to the nutritional and health values of Perilla frutescens L, it has become a potential medicinal and edible crop. Two Per- ilia frutescens cultivars, Qisu No.1 （oil type） and Qisu No.3 （leaf and seed-using type）, bred by Rapeseed Research Institute of Guizhou Academy of Agricultural Sciences, were used as test material for studying the effects of different planting density on the economic yield and agronomic characters of Perilla frutescens L. under moderate fertility level. The results showed the variation tendency of agro- nomic characters with the change of planting density was similar for the two Perilla frutescens cultivars. Among them, the plant height, main-stem nods, first effective branch length, first effective branch height, spikes per plant, and yield per plant were negatively related to the planting density; and main spike length and main- spike grains were positively related to the planting density. The effects of planting density on kilo-grain weight were not significant. The yield of the two cuitivars all increased first and then decreased with the increase of planting density. The re- gression analysis of planting density versus yield of Perilla frutescens L. was per- formed for obtaining the regression equations （Qisu No.l： y=54.046 5＋96.777 lx- 45.719 8x2, r=0.999 4; Qisu No.3：y=38.717 6＋42.111 3x-16.757 7x2, r=0.999 8）. Based on the regression equations, the optimal planting density for Qisu No.1 was 158 745 plants/hm2 with peak yield of 1 578.90 kg/hm2, and for Qisu No.3 was 188 745 plants/hm2 with peak yield of 977.55 kg/hm2. Under the optimal planting density, Qisu No.3 could also harvest 3 000 kg/hm2 of Perilla frutescens dry leaves and 2 400 kg/hm2 of Perilla frutescens stems. This research would provide an important reference for the promotion, high-yield cultivation and comprehensive utilization of Perilla frutescens L.展开更多
Monoclonal antibody （mAb）-based therapeutics are playing an increasingly important role in the treatment or pre- vention of many important diseases such as cancers, autoimmune disorders, and infectious diseases. Mul...Monoclonal antibody （mAb）-based therapeutics are playing an increasingly important role in the treatment or pre- vention of many important diseases such as cancers, autoimmune disorders, and infectious diseases. Multi- domain mAbs are far more complex than small molecule drugs with intrinsic heterogeneities. The critical quality attributes of a given mAb, including structure, post-trans- lational modifications, and functions at biomolecular and cellular levels, need to be defined and profiled in details during the developmental phases of a biologics. These critical quality attributes, outlined in this review, serve an important database for defining the drug properties during commercial production phase as well as post licensure life cycle managemenL Specially, the molecular characteriza- tion, functional assessment, and effector function analysis of mAbs, are reviewed with respect to the critical parame- ters and the methods used for obtaining them. The three groups of analytical methods are three essential and inte. gral facets making up the whole analytical package for a mAIPbased drug. Such a package is critically important for the licensure and the post-licensurs life cycle management of a therapeutic or prophylactic biologics. In addition, the basic principles on the evaluation of biosimilar mAbs were discussed briefly based on the recommendations by the World Health Organization.展开更多
基金Supported by National Natural Science Foundation of China(31360067)Guiyang Science and Technology Plan Project(Cultivation Plan of Innovative Talents-Young Science and Technology Talents Training Subsidy)(ZKHT[2012HK]209-36)+1 种基金Agriculture Animal and Plant Breeding Special of Guizhou Province(QNYZ[2013]019)Special Fund of Guizhou Academy of Agricultural Sciences(QKH[2011]017)~~
文摘Perilla frutescens L. is a traditional medicinal plant in china. In recent years, with more and more attention is paid to the nutritional and health values of Perilla frutescens L, it has become a potential medicinal and edible crop. Two Per- ilia frutescens cultivars, Qisu No.1 （oil type） and Qisu No.3 （leaf and seed-using type）, bred by Rapeseed Research Institute of Guizhou Academy of Agricultural Sciences, were used as test material for studying the effects of different planting density on the economic yield and agronomic characters of Perilla frutescens L. under moderate fertility level. The results showed the variation tendency of agro- nomic characters with the change of planting density was similar for the two Perilla frutescens cultivars. Among them, the plant height, main-stem nods, first effective branch length, first effective branch height, spikes per plant, and yield per plant were negatively related to the planting density; and main spike length and main- spike grains were positively related to the planting density. The effects of planting density on kilo-grain weight were not significant. The yield of the two cuitivars all increased first and then decreased with the increase of planting density. The re- gression analysis of planting density versus yield of Perilla frutescens L. was per- formed for obtaining the regression equations （Qisu No.l： y=54.046 5＋96.777 lx- 45.719 8x2, r=0.999 4; Qisu No.3：y=38.717 6＋42.111 3x-16.757 7x2, r=0.999 8）. Based on the regression equations, the optimal planting density for Qisu No.1 was 158 745 plants/hm2 with peak yield of 1 578.90 kg/hm2, and for Qisu No.3 was 188 745 plants/hm2 with peak yield of 977.55 kg/hm2. Under the optimal planting density, Qisu No.3 could also harvest 3 000 kg/hm2 of Perilla frutescens dry leaves and 2 400 kg/hm2 of Perilla frutescens stems. This research would provide an important reference for the promotion, high-yield cultivation and comprehensive utilization of Perilla frutescens L.
文摘Monoclonal antibody （mAb）-based therapeutics are playing an increasingly important role in the treatment or pre- vention of many important diseases such as cancers, autoimmune disorders, and infectious diseases. Multi- domain mAbs are far more complex than small molecule drugs with intrinsic heterogeneities. The critical quality attributes of a given mAb, including structure, post-trans- lational modifications, and functions at biomolecular and cellular levels, need to be defined and profiled in details during the developmental phases of a biologics. These critical quality attributes, outlined in this review, serve an important database for defining the drug properties during commercial production phase as well as post licensure life cycle managemenL Specially, the molecular characteriza- tion, functional assessment, and effector function analysis of mAbs, are reviewed with respect to the critical parame- ters and the methods used for obtaining them. The three groups of analytical methods are three essential and inte. gral facets making up the whole analytical package for a mAIPbased drug. Such a package is critically important for the licensure and the post-licensurs life cycle management of a therapeutic or prophylactic biologics. In addition, the basic principles on the evaluation of biosimilar mAbs were discussed briefly based on the recommendations by the World Health Organization.
