Some attributes are uncertain for evaluation work because of incomplete or limited information and knowledge.It leads to uncertainty in evaluation results.To that end,an evaluation method,uncertainty entropy-based exp...Some attributes are uncertain for evaluation work because of incomplete or limited information and knowledge.It leads to uncertainty in evaluation results.To that end,an evaluation method,uncertainty entropy-based exploratory evaluation(UEEE),is proposed to guide the evaluation activities,which can iteratively and gradually reduce uncertainty in evaluation results.Uncertainty entropy(UE)is proposed to measure the extent of uncertainty.First,the belief degree distributions are assumed to characterize the uncertainty in attributes.Then the belief degree distribution of the evaluation result can be calculated by using uncertainty theory.The obtained result is then checked based on UE to see if it could meet the requirements of decision-making.If its uncertainty level is high,more information needs to be introduced to reduce uncertainty.An algorithm based on the UE is proposed to find which attribute can mostly affect the uncertainty in results.Thus,efforts can be invested in key attribute(s),and the evaluation results can be updated accordingly.This update should be repeated until the evaluation result meets the requirements.Finally,as a case study,the effectiveness of ballistic missiles with uncertain attributes is evaluated by UEEE.The evaluation results show that the target is believed to be destroyed.展开更多
Jumong is a legendary figure in Korean mythology.He is depicted as a genius archer,a brilliant mind with horses,a god who rules the rivers and the sky.Jumong is a mythical character who is believed to be of divine des...Jumong is a legendary figure in Korean mythology.He is depicted as a genius archer,a brilliant mind with horses,a god who rules the rivers and the sky.Jumong is a mythical character who is believed to be of divine descent and to possess superhuman abilities that humans cannot match.The myth of Jumong is a very competitive content that can compete on a global scale.However,in order for it to be successful,it is necessary to be able to reinterpret our mythology to suit the times and reproduce it culturally.To this end,the realistic globalization of Korean classical literature should commence with the genre of Korean mythology.This paper presents the educational significance of the Jumong myth as a teaching-learning model,via STEAM(science,technology,engineering,arts,and mathematics),on the theme of Korean mythology.As we enter the era of artificial intelligence(AI)through the 4th Industrial Revolution,the most appropriate teaching and learning method,the convergence class,will provide an opportunity for students living in modern times to discover the cultural archetypes that allow them to recognise themselves as individuals and us as a collective,and to find the roots of the myth to positively renew their identity.Furthermore,it is my hope that they will rediscover and appreciate the representative work of Korean mythology,Gojomong,the eponymous story of Goguryeo.展开更多
Continued innovation in screening methodologies remains important for the discovery of high-quality multiactive fungi,which have been of great significance to the development of new drugs.Mangrove-derived fungi,which ...Continued innovation in screening methodologies remains important for the discovery of high-quality multiactive fungi,which have been of great significance to the development of new drugs.Mangrove-derived fungi,which are well recognized as prolific sources of natural products,are worth sustained attention and further study.In this study,118 fungi,which mainly included Aspergillus spp.(34.62%)and Penicillium spp.(15.38%),were isolated from the mangrove ecosystem of the Maowei Sea,and 83.1%of the cultured fungi showed at least one bioactivity in four antibacterial and three antioxidant assays.To accurately evaluate the fungal bioactivities,the fungi with multiple bioactivities were successfully evaluated and screened by principal component analysis(PCA),and this analysis provided a dataset for comparing and selecting multibioactive fungi.Among the 118 mangrove-derived fungi tested in this study,Aspergillus spp.showed the best comprehensive activity.Fungi such as A.clavatonanicus,A.flavipes and A.citrinoterreus,which exhibited high comprehensive bioactivity as determined by the PCA,have great potential in the exploitation of natural products and the development of new drugs.This study demonstrated the first use of PCA as a time-saving,scientific method with a strong ability to evaluate and screen multiactive fungi,which indicated that this method can affect the discovery and development of new drugs.展开更多
Evaluation is the major activity of performing Verification, Validation and Accreditation (VV&A) of a simulation system. Unfortunately, there is a lack of reasonable and operable evaluation methods. Moreover, ther...Evaluation is the major activity of performing Verification, Validation and Accreditation (VV&A) of a simulation system. Unfortunately, there is a lack of reasonable and operable evaluation methods. Moreover, there are other problems to address in VV&A evaluation, such as index definition, conclusion analysis, etc. In this paper, a VV&A evaluation system is introduced to try to resolve these problems. The system is based on a method called hierarchical evaluation, and it uses a good combination of evaluation processes and indexes. First, a thorough analysis of the VV&A evaluation’s essentials and principles are given, then the uncertainty of the evaluation results caused by various analysis of the evaluators is pointed out, then a hierarchical evaluation mechanism based on evaluator weight and evaluation hierarchy is brought forward, and finally a comprehensive VV&A evaluation system with evaluation flow processing, index management and hierarchical evaluation fulfillment is established. The system gives good consideration to ease of operation, reasonableness of evaluation conclusion, and the ability to comprehensively resolve VV&A problems. Since VV&A is attracting more and more recognition, it is meaningful to provide a good system for implementing credible simulation systems. It is hoped that this VV&A evaluation will provide a good way.展开更多
In order to monitor the basic mechanical properties and interior damage of concrete structures,the piezoelectric actuator/sensor based wave propagation method was investigated experimentally in the laboratory using a ...In order to monitor the basic mechanical properties and interior damage of concrete structures,the piezoelectric actuator/sensor based wave propagation method was investigated experimentally in the laboratory using a specifically designed test setup.The energy attenuation of stress waves was measured by the relative index between the output voltage of sensors and the excitation voltage at the actuator.Based on the experimental results of concrete cube and cylinder specimens,the effect of excitation frequencies,excitation amplitude,wave propagation paths and the curing age on the output signals of sensors are evaluated.The results show that the relative voltage attenuation coefficient RVAC is an effective indicator for measuring the attenuation of stress waves through the interior of concrete.展开更多
The marine environment provides rich and varied resources and services or functions for human’s produc-tion and life. Many countries have competitively exploited and utilized sea and ocean to develop marine economy f...The marine environment provides rich and varied resources and services or functions for human’s produc-tion and life. Many countries have competitively exploited and utilized sea and ocean to develop marine economy for someyears. The over-exploitation of marine environment and the overuse of marine resources have led to resource degradation,environmental pollution and ecosystem destruction. Considering the depletion of coastal environmental resources dur-ing planning, governing and decision-making is an important measure to promote the harmonious and sustainabledevelopment of coastal environmental resources and social economy, the main precondition of which is that the depletionof coastal environmental resources by human activities has been monetarily evaluated. Firstly, this paper summarizesrelevant references in this field and analyzes different sorts of depletion of coastal environmental resources caused byhuman activities and the necessity and importance of the monetary evaluation. Finally, this paper extensively discussesthe corresponding evaluation models of the depletion of marine mineral resources, marine organism resources, mari-time transport resources, intertidal zones and shallow seas, and marine environmental functions and services includingenvironmental capacity, gas regulation, disturbance prevention, recreation and biodiversity.展开更多
One of the latest sources of alternative energy, bioethanol, has been the focus of modem research, The production of bioethanol is commonly restricted by the activity of cellulase. Therefore, cellulase has become one ...One of the latest sources of alternative energy, bioethanol, has been the focus of modem research, The production of bioethanol is commonly restricted by the activity of cellulase. Therefore, cellulase has become one of the critical issues in the conversion of lignocelluloses to bioethanol. This article is an overview of the sources and factors affecting enzyme activity, as well as methods of evaluation and utilizations of cellulase. We conclude that a combination of cellulases from various strains can enhance hydrolysis of substrates. Large enough amounts of cellobiase or sufficient cellobiase activity can reduce the inhibition to exoglucanase activity of cellobiose. Characterization and exploitation of cellulase should focus on a definite substrate. Promotion and mixed incubation of strains can reduce the cost of industrial utilization of cellulase.展开更多
Replacement of precious single metal catalysts with cost-effective,highly-dispersed composite catalysts for catalytic hydrothermal conversion of residue holds tremendous promise for the residue upgrading technologies....Replacement of precious single metal catalysts with cost-effective,highly-dispersed composite catalysts for catalytic hydrothermal conversion of residue holds tremendous promise for the residue upgrading technologies.Organic metals were added to the feed as the oil-soluble precursors,and were transformed into the catalytic active phases in this work.Physical properties and structures of the composite catalysts had been investigated by X-ray fluorescence spectroscopy,X-ray photoelectron spectroscopy,X-ray diffraction,scanning electron microscopy and transmission electron microscopy.The composite catalysts were found to be highly efficient in the catalytic hydrothermal conversion of both the model compound and the residue.Increased metal dispersion and synergistic effects of two metals played indispensable roles in such catalytic system.Results showed that under the test conditions specified in the article,the catalyst had the best catalytic performance when the mass ratio of molybdenum to iron was 1.5.展开更多
Non-alcoholic fatty liver disease(NAFLD),a type of liver disease for which no treatment is currently approved,remains a major concern worldwide.It is manifested as simple hepatocyte steatosis and can develop into infl...Non-alcoholic fatty liver disease(NAFLD),a type of liver disease for which no treatment is currently approved,remains a major concern worldwide.It is manifested as simple hepatocyte steatosis and can develop into inflam-mation,fibrosis,cirrhosis and liver cancer in severe cases.However,due to the lack of appropriate in vitro drug testing platforms,an in-depth understanding of the therapeutic activity of ginsenoside Rb_(1)in NAFLD remains challenging.Here,we proposed a NAFLD model on a liver organoids(LOs)-on-a-chip platform to evaluate the therapeutic effect of ginsenoside Rb_(1)in a dynamic,multi-condition and high-throughput manner.This platform allowed us to reshape certain features such as multicellular types and liver-specific functions of the physiology of the human-relative liver.Free fatty acids(FFAs)-induced LOs displayed typical pathological characteristics of NAFLD progression,including steatosis,oxidative stress,lipid peroxidation,inflammation and fibrosis.With ginsenoside Rb_(1)intervention,these pathological features can be significantly improved,which may provide new insights into the potential mechanisms of NAFLD progression and treatment and suggest the clinical implications for humans.The proposed system enables the formation,differentiation,and function of LOs to serve as a scalable,high-throughput and sensitive drug testing model,to potentially expedite the NAFLD drug discovery.展开更多
We have developed a personal-computer-based water quality analysis system for river basins. The system estimates potential N outflow by model and calculates actual N outflow from monitoring data. For the former it use...We have developed a personal-computer-based water quality analysis system for river basins. The system estimates potential N outflow by model and calculates actual N outflow from monitoring data. For the former it uses the potential load factor method to estimate annual nitrogen load from various sources and runoff potential from each area of land in a basin. For the latter it analyzes water quality monitoring data in relation to meteorological data. We used the system to analyze N outflow in basins around Lake Kasumigaura and the Yahagi River in central Honshu, Japan. The land around Lake Kasumigaura is rather flat, and about 25% is periodically flooded for rice and lotus cultivation. The land around the Yahagi River is mountainous, and much less land is flooded. In the Yahagi River basin the actual N outflow agreed closely with the potential. However, the actual N outflow in the basin around Lake Kasumigaura was much less than the potential, suggesting that a large part of the N load is denitrified in flooded soils. This further indicates that a sequence of different land uses including flooded rice fields is an important factor determining N outflow in basins in Japan. On the basis of the above analyses, we incorporated a denitrification model into the system that enables us to estimate N balance in a designated basin;this system may be helpful in the formulation of scenarios of land use andsoil management for improving water quality.展开更多
基金the National Natural Science Foundation of China(61872378).
文摘Some attributes are uncertain for evaluation work because of incomplete or limited information and knowledge.It leads to uncertainty in evaluation results.To that end,an evaluation method,uncertainty entropy-based exploratory evaluation(UEEE),is proposed to guide the evaluation activities,which can iteratively and gradually reduce uncertainty in evaluation results.Uncertainty entropy(UE)is proposed to measure the extent of uncertainty.First,the belief degree distributions are assumed to characterize the uncertainty in attributes.Then the belief degree distribution of the evaluation result can be calculated by using uncertainty theory.The obtained result is then checked based on UE to see if it could meet the requirements of decision-making.If its uncertainty level is high,more information needs to be introduced to reduce uncertainty.An algorithm based on the UE is proposed to find which attribute can mostly affect the uncertainty in results.Thus,efforts can be invested in key attribute(s),and the evaluation results can be updated accordingly.This update should be repeated until the evaluation result meets the requirements.Finally,as a case study,the effectiveness of ballistic missiles with uncertain attributes is evaluated by UEEE.The evaluation results show that the target is believed to be destroyed.
基金support of the Korea University of Education and Training Center for Convergence Education(2019-2022).
文摘Jumong is a legendary figure in Korean mythology.He is depicted as a genius archer,a brilliant mind with horses,a god who rules the rivers and the sky.Jumong is a mythical character who is believed to be of divine descent and to possess superhuman abilities that humans cannot match.The myth of Jumong is a very competitive content that can compete on a global scale.However,in order for it to be successful,it is necessary to be able to reinterpret our mythology to suit the times and reproduce it culturally.To this end,the realistic globalization of Korean classical literature should commence with the genre of Korean mythology.This paper presents the educational significance of the Jumong myth as a teaching-learning model,via STEAM(science,technology,engineering,arts,and mathematics),on the theme of Korean mythology.As we enter the era of artificial intelligence(AI)through the 4th Industrial Revolution,the most appropriate teaching and learning method,the convergence class,will provide an opportunity for students living in modern times to discover the cultural archetypes that allow them to recognise themselves as individuals and us as a collective,and to find the roots of the myth to positively renew their identity.Furthermore,it is my hope that they will rediscover and appreciate the representative work of Korean mythology,Gojomong,the eponymous story of Goguryeo.
基金the Key R&D Program of Shandong Province(No.2020CXGC010703)the Key Project of the Natural Science Foundation of Shandong Province(No.ZR2020 KB021)。
文摘Continued innovation in screening methodologies remains important for the discovery of high-quality multiactive fungi,which have been of great significance to the development of new drugs.Mangrove-derived fungi,which are well recognized as prolific sources of natural products,are worth sustained attention and further study.In this study,118 fungi,which mainly included Aspergillus spp.(34.62%)and Penicillium spp.(15.38%),were isolated from the mangrove ecosystem of the Maowei Sea,and 83.1%of the cultured fungi showed at least one bioactivity in four antibacterial and three antioxidant assays.To accurately evaluate the fungal bioactivities,the fungi with multiple bioactivities were successfully evaluated and screened by principal component analysis(PCA),and this analysis provided a dataset for comparing and selecting multibioactive fungi.Among the 118 mangrove-derived fungi tested in this study,Aspergillus spp.showed the best comprehensive activity.Fungi such as A.clavatonanicus,A.flavipes and A.citrinoterreus,which exhibited high comprehensive bioactivity as determined by the PCA,have great potential in the exploitation of natural products and the development of new drugs.This study demonstrated the first use of PCA as a time-saving,scientific method with a strong ability to evaluate and screen multiactive fungi,which indicated that this method can affect the discovery and development of new drugs.
文摘Evaluation is the major activity of performing Verification, Validation and Accreditation (VV&A) of a simulation system. Unfortunately, there is a lack of reasonable and operable evaluation methods. Moreover, there are other problems to address in VV&A evaluation, such as index definition, conclusion analysis, etc. In this paper, a VV&A evaluation system is introduced to try to resolve these problems. The system is based on a method called hierarchical evaluation, and it uses a good combination of evaluation processes and indexes. First, a thorough analysis of the VV&A evaluation’s essentials and principles are given, then the uncertainty of the evaluation results caused by various analysis of the evaluators is pointed out, then a hierarchical evaluation mechanism based on evaluator weight and evaluation hierarchy is brought forward, and finally a comprehensive VV&A evaluation system with evaluation flow processing, index management and hierarchical evaluation fulfillment is established. The system gives good consideration to ease of operation, reasonableness of evaluation conclusion, and the ability to comprehensively resolve VV&A problems. Since VV&A is attracting more and more recognition, it is meaningful to provide a good system for implementing credible simulation systems. It is hoped that this VV&A evaluation will provide a good way.
基金Funded by the National Natural Science Foundation of China (No.50708065)the National High-tech R&D Program(863 Program )(No.2007-AA-11-Z-113)the Key Projects in the Science and Technology Pillar Program of Tianjin(No.11ZCKFSF00300)
文摘In order to monitor the basic mechanical properties and interior damage of concrete structures,the piezoelectric actuator/sensor based wave propagation method was investigated experimentally in the laboratory using a specifically designed test setup.The energy attenuation of stress waves was measured by the relative index between the output voltage of sensors and the excitation voltage at the actuator.Based on the experimental results of concrete cube and cylinder specimens,the effect of excitation frequencies,excitation amplitude,wave propagation paths and the curing age on the output signals of sensors are evaluated.The results show that the relative voltage attenuation coefficient RVAC is an effective indicator for measuring the attenuation of stress waves through the interior of concrete.
基金supported by National Natural Science Foundation of China(Grant No.70371020)Natural Science Foundation of Fujian Province(Grant No.D0410005).
文摘The marine environment provides rich and varied resources and services or functions for human’s produc-tion and life. Many countries have competitively exploited and utilized sea and ocean to develop marine economy for someyears. The over-exploitation of marine environment and the overuse of marine resources have led to resource degradation,environmental pollution and ecosystem destruction. Considering the depletion of coastal environmental resources dur-ing planning, governing and decision-making is an important measure to promote the harmonious and sustainabledevelopment of coastal environmental resources and social economy, the main precondition of which is that the depletionof coastal environmental resources by human activities has been monetarily evaluated. Firstly, this paper summarizesrelevant references in this field and analyzes different sorts of depletion of coastal environmental resources caused byhuman activities and the necessity and importance of the monetary evaluation. Finally, this paper extensively discussesthe corresponding evaluation models of the depletion of marine mineral resources, marine organism resources, mari-time transport resources, intertidal zones and shallow seas, and marine environmental functions and services includingenvironmental capacity, gas regulation, disturbance prevention, recreation and biodiversity.
文摘One of the latest sources of alternative energy, bioethanol, has been the focus of modem research, The production of bioethanol is commonly restricted by the activity of cellulase. Therefore, cellulase has become one of the critical issues in the conversion of lignocelluloses to bioethanol. This article is an overview of the sources and factors affecting enzyme activity, as well as methods of evaluation and utilizations of cellulase. We conclude that a combination of cellulases from various strains can enhance hydrolysis of substrates. Large enough amounts of cellobiase or sufficient cellobiase activity can reduce the inhibition to exoglucanase activity of cellobiose. Characterization and exploitation of cellulase should focus on a definite substrate. Promotion and mixed incubation of strains can reduce the cost of industrial utilization of cellulase.
基金This work is financially supported by the China Petroleum and Chemical Corporation(SINOPEC 120063-1).
文摘Replacement of precious single metal catalysts with cost-effective,highly-dispersed composite catalysts for catalytic hydrothermal conversion of residue holds tremendous promise for the residue upgrading technologies.Organic metals were added to the feed as the oil-soluble precursors,and were transformed into the catalytic active phases in this work.Physical properties and structures of the composite catalysts had been investigated by X-ray fluorescence spectroscopy,X-ray photoelectron spectroscopy,X-ray diffraction,scanning electron microscopy and transmission electron microscopy.The composite catalysts were found to be highly efficient in the catalytic hydrothermal conversion of both the model compound and the residue.Increased metal dispersion and synergistic effects of two metals played indispensable roles in such catalytic system.Results showed that under the test conditions specified in the article,the catalyst had the best catalytic performance when the mass ratio of molybdenum to iron was 1.5.
基金supported by the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Projects(TSBICIP-CXRC-008)Major Project of Haihe Laboratory of Synthetic Biology(E2M9560201)+1 种基金National Natural Science Foundation of China(32301210&31200035)the China Postdoctoral Science Foundation(No.2022M713330).
文摘Non-alcoholic fatty liver disease(NAFLD),a type of liver disease for which no treatment is currently approved,remains a major concern worldwide.It is manifested as simple hepatocyte steatosis and can develop into inflam-mation,fibrosis,cirrhosis and liver cancer in severe cases.However,due to the lack of appropriate in vitro drug testing platforms,an in-depth understanding of the therapeutic activity of ginsenoside Rb_(1)in NAFLD remains challenging.Here,we proposed a NAFLD model on a liver organoids(LOs)-on-a-chip platform to evaluate the therapeutic effect of ginsenoside Rb_(1)in a dynamic,multi-condition and high-throughput manner.This platform allowed us to reshape certain features such as multicellular types and liver-specific functions of the physiology of the human-relative liver.Free fatty acids(FFAs)-induced LOs displayed typical pathological characteristics of NAFLD progression,including steatosis,oxidative stress,lipid peroxidation,inflammation and fibrosis.With ginsenoside Rb_(1)intervention,these pathological features can be significantly improved,which may provide new insights into the potential mechanisms of NAFLD progression and treatment and suggest the clinical implications for humans.The proposed system enables the formation,differentiation,and function of LOs to serve as a scalable,high-throughput and sensitive drug testing model,to potentially expedite the NAFLD drug discovery.
文摘We have developed a personal-computer-based water quality analysis system for river basins. The system estimates potential N outflow by model and calculates actual N outflow from monitoring data. For the former it uses the potential load factor method to estimate annual nitrogen load from various sources and runoff potential from each area of land in a basin. For the latter it analyzes water quality monitoring data in relation to meteorological data. We used the system to analyze N outflow in basins around Lake Kasumigaura and the Yahagi River in central Honshu, Japan. The land around Lake Kasumigaura is rather flat, and about 25% is periodically flooded for rice and lotus cultivation. The land around the Yahagi River is mountainous, and much less land is flooded. In the Yahagi River basin the actual N outflow agreed closely with the potential. However, the actual N outflow in the basin around Lake Kasumigaura was much less than the potential, suggesting that a large part of the N load is denitrified in flooded soils. This further indicates that a sequence of different land uses including flooded rice fields is an important factor determining N outflow in basins in Japan. On the basis of the above analyses, we incorporated a denitrification model into the system that enables us to estimate N balance in a designated basin;this system may be helpful in the formulation of scenarios of land use andsoil management for improving water quality.
