Available information on the microbial mechanisms associated with heavy metal(HM)passivation during co-composting amended with phosphate rock(PR)remains limited.Thus,this study investigated the dynamic changes in bact...Available information on the microbial mechanisms associated with heavy metal(HM)passivation during co-composting amended with phosphate rock(PR)remains limited.Thus,this study investigated the dynamic changes in bacterial communities and HM-fractions(Zn,Cu,Cd,Cr and Pb)during swine manure composting with maize straw,and ascertained the bacterial influence on HM-passivation.The results demonstrated that the addition of PR improved HM-passivation,especially for Zn and Cd,with their bioavailability factors(BFs)reduced by 247.41 and 176.25%,respectively.As for bacterial communities,the proportion of Firmicutes decreased,while the proportions of Proteobacteria,Bacteroidetes,DeinococcusThermus and Gemmatimonadetes increased in all treatments.PR significantly changed the primary bacterial phyla in the thermophilic phase.Bacteroidetes were the main bacterial component controlling the passivation of Zn,Cu and Cr,while Deinococcus-Thermus mainly regulated the mobility of Zn and Pb,and Proteobacteria only dominated the transformation among Cd-fractions.These results may provide a reference for the use of HM-passivation techniques during composting.展开更多
Static aerobic composting of municipal sewage sludge with forced ventilation or air ventilation using matured compost as bulking conditioner was investigated.Physical and chemical parameters,e.g.,temperature,moisture ...Static aerobic composting of municipal sewage sludge with forced ventilation or air ventilation using matured compost as bulking conditioner was investigated.Physical and chemical parameters,e.g.,temperature,moisture content,VSS,CODcr,pH,and germination index(GI),were analyzed to characterize the composting process.Fermentation starts quickly in both forced and air ventilation compost heaps and reaches high-temperature stage after 2 d,owing to the bulking function of matured compost.Compared to air ventilation,however,forced ventilation enables the high-temperature stage to last longer for approximately 7 d.The moisture content of both compost bodies decreases from 62% to about 50% as a result of evaporation,and it decreases slightly faster in forced ventilation compost heap after 13 d due to the higher temperature and better ventilation condition.Although no obvious differences of VSS and pH are observed between both compost heaps,the soluble CODCr and GI show differences during the second half period of fermentation.In forced ventilation compost,the soluble CODCr has a small rebound after 13 d,and GI decreases from 46% to 35% but then increases.These results show that in general,the matured compost is a good conditioner and force ventilation with a proper air supply strategy can be more efficient than air ventilation.展开更多
Oxytetracycline(OTC) and tetracycline(TC) are the most common TC antibiotics used in human and veterinary medicine.Residual amounts of these antibiotics in manure pose a potential threat to public and ecological healt...Oxytetracycline(OTC) and tetracycline(TC) are the most common TC antibiotics used in human and veterinary medicine.Residual amounts of these antibiotics in manure pose a potential threat to public and ecological health as a result of the potential for them to be released to the environment following land application of manure from animals treated with antibiotics.We investigated the degradation of OTC and TC during anaerobic composting.We tested the effects of temperature and antibiotic concentration on degradation rates in a control and in manure spiked with TCs.We examined changes in p H,biological degradation material(BDM),and moisture corresponding with antibiotic degradation of TCs in the swine manure.Results showed that the OTC and TC concentrations decreased by between 68.54% and 95.50% in all nine treatments following 14 days of anaerobic composting,and the highest removal ef ficiencies were observed at an incubation temperature of 55°C and initial concentrations of 10.36 μg·g^(-1),and 5.96 μg·g^(-1) of OTC and TC,respectively,which were degraded by 95.50%,and 90.06%.During composting at 55 °C and at added concentrations of 5 μg·g^(-1),OTC decreased rapidly,and the time required for50% and 90% degradation was 4.1 and 9.8 days,respectively;for TC,these values were 4.4 and 14.0 days,respectively.Removal ef ficiencies for all TCs correlated well with moisture content of the manure.These results show that composting may be a practical and useful means to reduce concentrations of OTC and TC in swine manure prior to its land application.展开更多
Bench-scale treatments with three mixtures of Mg and P salts,including K3PO4+MgSO4,K2HPO4+MgSO4,and KH2PO4+MgSO4 as additives in a simulated food waste aerobic composting process,were conducted to test the magnesium a...Bench-scale treatments with three mixtures of Mg and P salts,including K3PO4+MgSO4,K2HPO4+MgSO4,and KH2PO4+MgSO4 as additives in a simulated food waste aerobic composting process,were conducted to test the magnesium ammonium phosphate(MAP) formation,and the compost products were analyzed by X-ray diffraction(XRD),Scanning electron microscopy(SEM),and Energy dispersive X-ray spectroscopy(EDS) analyses.The comparison results between XRD,SEM,and EDS analyses of MAPs in the dried compost and synthesized MAPs confirm the formation of MAP crystals in the simulated food waste aerobic composting process.The analysis of the compost also indicates that the addition of all the three mixtures of Mg and P salts in the aerobic composting process can increase nitrogen conservation and decrease nitrogen loss because of the formation of MAPs.The mechanism of MAP formation was verified as the reaction of ammonium(NH4+) with magnesium(Mg2+) and phosphate[HnPO4(3-n)-,n=0,1,and 2).展开更多
For the control of environment pollution caused by livestock and poultry manure,four microbial strains conducive to aerobic composting were selected and mixed into four compound microbial agents,and effects of differe...For the control of environment pollution caused by livestock and poultry manure,four microbial strains conducive to aerobic composting were selected and mixed into four compound microbial agents,and effects of different compound microbial agents on aerobic composting of cow manure were studied from aspects of changes in temperature,pH,water content and C/N during the composting process.The results show that microbial agent M2 has the best effect for aerobic composting of cow manure,so microbial agent M2 has broad popularization and application prospect in livestock and poultry farms in low-temperature areas of Northeast China.展开更多
Alzheimer's disease (AD) is an irreversible neurodegenerative disease with a variety of pathogenic factors and complex pathogenesis, so that the disease has a high prevalence and mortality in the world. Although t...Alzheimer's disease (AD) is an irreversible neurodegenerative disease with a variety of pathogenic factors and complex pathogenesis, so that the disease has a high prevalence and mortality in the world. Although the current diagnosis and treatment equipment and drug research and development keep pace with the times, the current medical technology still can not completely cure the disease, so it is of great significance to explore the pathogenesis and treatment target of AD. The disorder of energy metabolism is one of the characteristic changes in the pathological process of AD. Aerobic glycolysis (AEG) is a special metabolic pathway in the brain, which can rapidly consume glucose to produce energy and substrate for neurons, improve synaptic plasticity, neuroinflammation and oxidative damage, and contribute to the recovery of memory and cognitive function. In recent years, many literatures have reported the mechanism of AEG in AD and the intervention of Tradit Chin Med on this mechanism. The purpose of this paper is to summarize the role of AEG in AD and the related research on the regulation and control of AEG in the treatment of AD by Tradit Chin Med, in order to provide reference and ideas for the prevention and treatment of AD with Tradit Chin Med in the future.展开更多
Composting as a solution to the increasing generation of municipal solid waste (MSW), also contribute to GHGs emission when not controlled and could lack some basic nutrients, especially nitrogen. This study assessed ...Composting as a solution to the increasing generation of municipal solid waste (MSW), also contribute to GHGs emission when not controlled and could lack some basic nutrients, especially nitrogen. This study assessed the split-additions of nitrogen-rich substrate to composting materials and their effect on GHGs emissions as well as the quality of the composts. Nitrogen-rich substrates formulated from pig and goat manure were co-composted with MSW for a 12-weeks period by split adding at mesophilic (˚C) and thermophilic (>50˚C) stages in five different treatments. Representative samples from the compost were taken from each treatment for physicochemical, heavy metals and bacteriological analysis. In-situ CH<sub>4</sub>, CO<sub>2</sub>, N<sub>2</sub>O gas emissions were also analyzed weekly during composting. It was observed that all the treatments showed significant organic matter decomposition, reaching thermophilic temperatures in the first week of composting. The absence affects the suitable agronomic properties. All nitrogen-rich substrate applied at thermophilic stage (Treatment two) recorded the highest N, P and K concentrations of 1.34%, 0.97% and 2.45%, respectively with highest nitrogen retention. In terms of GHG emissions, CO<sub>2</sub> was highest at the thermophilic stage when N-rich substrate was added in all treatment, while CH<sub>4</sub> was highest in the mesophilic stage with N-rich substrate addition. N<sub>2</sub>O showed no specific trend in the treatments. Split addition of the N-rich substrate for co-composting of MSW produced compost which is stable, has less nutrient loss and low GHG emissions. Split addition of a nitrogen-rich substrate could be an option for increasing the fertilizer value of MSW compost.展开更多
Current knowledge about the transformation of total mercury and methylmercury(Me Hg) in aerobic composting process is limited. In this study, the composition and transformation of mercury and dissovled organic matter(...Current knowledge about the transformation of total mercury and methylmercury(Me Hg) in aerobic composting process is limited. In this study, the composition and transformation of mercury and dissovled organic matter(DOM) in aerobic composting process of municipal sewage sludge were were comprehensively characterized, and the differences among the three C/N ratio(20, 26 and 30) were investigated. The main form of mercury in C/N 20 and 26 was organo-chelated Hg(F3, 46%-60%);while the main form of mercury in C/N 30 was mercuric sulfide(F5, 64%-70%). The main component of DOM in C/N 20 and 26 were tyrosine-like substance(C1, 53%-76%) while the main fractions in C/N 30 were tyrosine-like substance(C1, 28%-37%) and fulvic-like substance(C2, 17%-39%). The mercury and DOM varied significantly during the 9 days composting process. Compared to C/N 20 and 26, C/N 30 produced the less Me Hg after aerobic composting process, with values of 658%(C/N 20), 1400%(C/N 26) and 139%(C/N 30) of the initial, respectively. Meanwhile, C/N 30 produced the best compost showed greater degree of DOM molecular condensation and humification. Hg fraction had been altered by DOM, as indicated by a significant correlation between mercury species and DOM components. Notably, C/N 30 should be used as an appropriate C/N ratio to control the methylation processes of mercury and degration of DOM.展开更多
Antibiotic resistance genes(ARGs)have been diffusely detected in several kinds of organic solid waste,such as livestock manure,sludge,antibiotic fermentation residues,and food waste,thus attracting great attention.Aer...Antibiotic resistance genes(ARGs)have been diffusely detected in several kinds of organic solid waste,such as livestock manure,sludge,antibiotic fermentation residues,and food waste,thus attracting great attention.Aerobic composting,which is an effective,harmless treatment method for organic solid waste to promote recycling,has been identified to also aid in ARG reduction.However,the effect of composting in removing ARGs from organic solid waste has recently become controversial.Thus,this article summarizes and reviews the research on ARGs in relation to composting in the past 5 years.ARGs in organic solid waste could spread in different environmental media,including soil and the atmosphere,which could widen environmental risks.However,the conventional composting technology had limited effect on ARGs removal from organic solid waste.Improved composting processes,such as hyperthermophilic temperature composting,could effectively remove ARGs,and the HGT of ARGs and the microbial communities are identified as vital influencing factors.Currently,during the composting process,ARGs were mainly affected by three response pathways,(Ⅰ)“Microenvironment-ARGs”;(Ⅱ)“Microenvironment-microorganisms-ARGs”;(Ⅲ)“Microorganisms-horizontal gene transfer-ARGs”,respectively.Response pathway Ⅱ had been studied the most which was believed that microbial community was an important factor affecting ARGs.In response pathway Ⅲ,mainly believed that MGEs played an important role and paid less attention to eARGs.Further research on the role and impact of eARGs in ARGs may be considered in the future.It aims to provide support for further research on environmental risk control of ARGs in organic solid waste.展开更多
The effects of adding a bulking agent and chemically pretreating municipal kitchen waste before aerobic composting were studied using a laboratory-scale system. The system used20-L reactors and each test lasted 28 day...The effects of adding a bulking agent and chemically pretreating municipal kitchen waste before aerobic composting were studied using a laboratory-scale system. The system used20-L reactors and each test lasted 28 days. The objective was to decrease NH3 and H2S emissions during composting. The bulking agent, dry cornstalks, was mixed with the kitchen waste to give a mixture containing 15%(wet weight) bulking agent. A combined treatment was also conducted, in which kitchen waste mixed with the bulking agent was pretreated with ferric chloride(FeC l3). Less leachate was produced by the composted kitchen waste mixed with bulking agent than by the kitchen waste alone, when the materials had reached the required maturity. The presence of cornstalks also caused less H2 S to be emitted, but had little impact on the amount of NH3 emitted. The FeC l3 was found to act as an effective chemical flocculant,and its presence significantly decreased the amounts of NH3 and H2S emitted. Kitchen waste mixed with cornstalks and treated with FeC l3 emitted 42% less NH3 and 76% less H2 S during composting than did pure kitchen waste.展开更多
Spent Coffee Ground (SCG) is characterized by high organic content, in the form of insoluble polysaccharides bound and phenol compounds. Phenol compounds are toxic to nature and <span style="font-family:Verdan...Spent Coffee Ground (SCG) is characterized by high organic content, in the form of insoluble polysaccharides bound and phenol compounds. Phenol compounds are toxic to nature and <span style="font-family:Verdana;">are</span><span style="font-family:Verdana;"> a cause of environmental pollution. Composting method of this study is aerobic static batch composting with temperature control with adding activators of some fungi such as </span><i><span style="font-family:Verdana;">Aspergillus sp</span></i><span style="font-family:Verdana;">, and </span><i><span style="font-family:Verdana;">Penicillium sp. </span></i><span style="font-family:Verdana;">The purpose of the research is to fill the research gap from previous studies of spent coffee grounds compost, which requires a long time in composting, so that if it is used directly on the soil and plants, the positive effect also requires a long time. The result of composting for 28 days with this method is that mature compost has black crumb and normal pH, with characteristics of C/N ratio below 10: C1 (7.06), C2 (6.99). This value is far from the control with a C/N ratio of 8.33. Decompose rate of macromolecule are above 40% for lignin and 70% for cellulose. Implementation of compost in radish plants, resulting Germination Index above 80% which indicates that the compost is ripe: control (92.39%), C1 (183.88%), C2 (191.86%). The results of the analysis with FTIR also showed that the compost was mature and stable, and rich in minerals. So, it can be concluded </span><span style="font-family:Verdana;">that</span><span style="font-family:Verdana;"> this composting method can speed up composting time and optimize the results of compost produced.</span>展开更多
This study evaluated the bioaugmentation potential of a quinoline-degrading strain Pseudomonas citronellolis LV1 inoculation into activated sludge for treating quinoline wastewater, and results indicated the inoculati...This study evaluated the bioaugmentation potential of a quinoline-degrading strain Pseudomonas citronellolis LV1 inoculation into activated sludge for treating quinoline wastewater, and results indicated the inoculation of LV1 in aerobic continuous MBBR could substantially improve the quinoline removal performance with an improved removal efficiency of 34% averagely when quinoline was used as the sole carbon and nitrogen source. Additionally, efficient removal of quinoline in enhanced MBBR occurred at the influent p H of 7.0–8.0, hydraulic retention time(HRT) of 24–28 h and influent quinoline concentration of 100–700 mg·L^(-1). High-throughput sequencing analysis indicated that bioaugmentation could increase microbial diversity and shape the microbial community structure. Although the inoculant LV1 did not remain its dominance in stage Ⅲ, bioaugmentation indeed induced the formation of effective microbial community, and the indigenous microbes including Flavobacterium, Pseudoxanthomonas,Pseudomonas, Vermamoeba, Dyadobacter and Sphingomonas might play the key role in quinoline removal.According to the PICRUSt, the enhanced genes encoding aromatic ring-cleavage enzyme, especially for Nheterocyclic ring-cleavage enzymes, could lead to the improved removal performance of quinoline in bioaugmentation stage. Moreover, the enhanced MBBR treated well actual coking wastewater, as indicated by high removal performance of quinoline, phenol and COD.展开更多
Objective:To investigate the impact of resistance training and aerobic exercise before doula-assisted delivery on the psychological well-being and labor duration of parturients.Methods:105 cases of parturients who gav...Objective:To investigate the impact of resistance training and aerobic exercise before doula-assisted delivery on the psychological well-being and labor duration of parturients.Methods:105 cases of parturients who gave birth in our hospital from February 2021 to April 2023 were included in this study.The patients were divided into a control group of 52 cases and an observation group of 53 cases.The patients in the control group received no particular intervention before delivery and only received doula assistance.The patients in the observation group received resistance training,aerobic exercise,and doula assistance prior to giving birth.After delivery,the mothers were observed for 2 hours in the delivery room and then returned to the maternal and infant ward.The observation indicators of the two groups were compared.Results:In comparison to the control group,the observation group exhibited shorter durations in the first,second,and third stages of labor,as well as the total delivery time.Additionally,the amount of postpartum blood loss at 2 hours was smaller in the observation group.The rate of cesarean section was lower,and the rate of vaginal natural delivery was higher in the observation group.Following the intervention,both groups of postpartum women showed decreased SAS and SDS scores compared to before the intervention.Moreover,the observation group had lower scores than the control group.These differences were all statistically significant(P<0.05).Conclusion:Resistance training and aerobic exercise before doula-assisted delivery can effectively improve the psychological state of parturients,shorten labor duration,increase the rate of natural vaginal delivery,and reduce pain and postpartum hemorrhage.展开更多
基金the National Key Research and Development Program of China(2018YFD0500205)the Strategic Priority Research Program of the Chinese Academy Sciences(XDA23070502)。
文摘Available information on the microbial mechanisms associated with heavy metal(HM)passivation during co-composting amended with phosphate rock(PR)remains limited.Thus,this study investigated the dynamic changes in bacterial communities and HM-fractions(Zn,Cu,Cd,Cr and Pb)during swine manure composting with maize straw,and ascertained the bacterial influence on HM-passivation.The results demonstrated that the addition of PR improved HM-passivation,especially for Zn and Cd,with their bioavailability factors(BFs)reduced by 247.41 and 176.25%,respectively.As for bacterial communities,the proportion of Firmicutes decreased,while the proportions of Proteobacteria,Bacteroidetes,DeinococcusThermus and Gemmatimonadetes increased in all treatments.PR significantly changed the primary bacterial phyla in the thermophilic phase.Bacteroidetes were the main bacterial component controlling the passivation of Zn,Cu and Cr,while Deinococcus-Thermus mainly regulated the mobility of Zn and Pb,and Proteobacteria only dominated the transformation among Cd-fractions.These results may provide a reference for the use of HM-passivation techniques during composting.
基金Projects(50978087,50908081)supported by the National Natural Science Foundation of China
文摘Static aerobic composting of municipal sewage sludge with forced ventilation or air ventilation using matured compost as bulking conditioner was investigated.Physical and chemical parameters,e.g.,temperature,moisture content,VSS,CODcr,pH,and germination index(GI),were analyzed to characterize the composting process.Fermentation starts quickly in both forced and air ventilation compost heaps and reaches high-temperature stage after 2 d,owing to the bulking function of matured compost.Compared to air ventilation,however,forced ventilation enables the high-temperature stage to last longer for approximately 7 d.The moisture content of both compost bodies decreases from 62% to about 50% as a result of evaporation,and it decreases slightly faster in forced ventilation compost heap after 13 d due to the higher temperature and better ventilation condition.Although no obvious differences of VSS and pH are observed between both compost heaps,the soluble CODCr and GI show differences during the second half period of fermentation.In forced ventilation compost,the soluble CODCr has a small rebound after 13 d,and GI decreases from 46% to 35% but then increases.These results show that in general,the matured compost is a good conditioner and force ventilation with a proper air supply strategy can be more efficient than air ventilation.
基金Supported by the Innovative Team Foundation of Zhejiang Province(2013TD12)the International Science and Technology Cooperation Program of China(2014DFE90040)the Significant Science and Technology Project of Zhejiang Province(2015C33006)
文摘Oxytetracycline(OTC) and tetracycline(TC) are the most common TC antibiotics used in human and veterinary medicine.Residual amounts of these antibiotics in manure pose a potential threat to public and ecological health as a result of the potential for them to be released to the environment following land application of manure from animals treated with antibiotics.We investigated the degradation of OTC and TC during anaerobic composting.We tested the effects of temperature and antibiotic concentration on degradation rates in a control and in manure spiked with TCs.We examined changes in p H,biological degradation material(BDM),and moisture corresponding with antibiotic degradation of TCs in the swine manure.Results showed that the OTC and TC concentrations decreased by between 68.54% and 95.50% in all nine treatments following 14 days of anaerobic composting,and the highest removal ef ficiencies were observed at an incubation temperature of 55°C and initial concentrations of 10.36 μg·g^(-1),and 5.96 μg·g^(-1) of OTC and TC,respectively,which were degraded by 95.50%,and 90.06%.During composting at 55 °C and at added concentrations of 5 μg·g^(-1),OTC decreased rapidly,and the time required for50% and 90% degradation was 4.1 and 9.8 days,respectively;for TC,these values were 4.4 and 14.0 days,respectively.Removal ef ficiencies for all TCs correlated well with moisture content of the manure.These results show that composting may be a practical and useful means to reduce concentrations of OTC and TC in swine manure prior to its land application.
基金Supported by the Scholarship from China Scholarship Council(No.22822053)
文摘Bench-scale treatments with three mixtures of Mg and P salts,including K3PO4+MgSO4,K2HPO4+MgSO4,and KH2PO4+MgSO4 as additives in a simulated food waste aerobic composting process,were conducted to test the magnesium ammonium phosphate(MAP) formation,and the compost products were analyzed by X-ray diffraction(XRD),Scanning electron microscopy(SEM),and Energy dispersive X-ray spectroscopy(EDS) analyses.The comparison results between XRD,SEM,and EDS analyses of MAPs in the dried compost and synthesized MAPs confirm the formation of MAP crystals in the simulated food waste aerobic composting process.The analysis of the compost also indicates that the addition of all the three mixtures of Mg and P salts in the aerobic composting process can increase nitrogen conservation and decrease nitrogen loss because of the formation of MAPs.The mechanism of MAP formation was verified as the reaction of ammonium(NH4+) with magnesium(Mg2+) and phosphate[HnPO4(3-n)-,n=0,1,and 2).
基金Supported by the National Science and Technology Project of Water Pollution Control and Management(2012ZX07202-009-002)
文摘For the control of environment pollution caused by livestock and poultry manure,four microbial strains conducive to aerobic composting were selected and mixed into four compound microbial agents,and effects of different compound microbial agents on aerobic composting of cow manure were studied from aspects of changes in temperature,pH,water content and C/N during the composting process.The results show that microbial agent M2 has the best effect for aerobic composting of cow manure,so microbial agent M2 has broad popularization and application prospect in livestock and poultry farms in low-temperature areas of Northeast China.
基金National Natural Science Foundation of China Regional Fund(No.82060844)Guangxi Natural Science Foundation General Project(No.2022GXNSFAA035461)+4 种基金Guangxi Clinical Medical Research Center for Tradit Chin Med Encephalopathy(No.Guike AD20238028)Academic Team Construction Project of the First Affiliated Hospital of Guangxi Univ Tradit Chin Med[Hospital Letter(2018)No.146]The 2020 Guangxi Higher Education High level Innovation Team and Outstanding Scholar Program[Guijiao Talent(2020)No.6]Guangxi Univ Tradit Chin Med"Qihuang Project"High level Talent Team Cultivation Project(No.2018003)Guangxi Key Discipline Construction Project of Tradit Chin Med(No.GZXK-Z-20-13)Alzheimer’s disease(AD)is an irreversible neurodegenerative disease.At present,the number of AD cases has exceeded 30 million and continues to rise in the world,especially in developing countries including China.Due to the superposition of factors such as an aging population,social pressure and improper lifestyle,it is speculated that the number of AD cases will double in the next 30 years[1].Although a large amount of money has been invested in the drug development and diagnosis and treatment of AD,the current medical methods can only delay the disease of AD but can not cure it completely.It is undeniable that AD is a recognized health problem and health problem in the current society.Therefore,it is particularly important to further study the molecular mechanism of AD in order to identify the pathogenic factors and therapeutic targets,and to explore effective treatment.Modern medicine believes that its pathological mechanism is complex and interact with each other,includingβ-amyloid(Aβ)toxic damage,abnormal modification of Tau protein,oxidative stress,neuroinflammation,mitochondrial dysfunction and so on[2].In fact,in the process of inevitable aging,the metabolic network is affected by related signal pathways,proteins and genes,which leads to the gradual down-regulation of aerobic glycolysis(AEG),which can directly or indirectly participate in the pathogenesis of the above-mentioned AD and affect its pathological changes.Therefore,taking AEG as the research target can provide a new idea for the prevention and treatment of AD.The name of AD disease is not seen in Tradit Chin Med,and it is Alzheimer's disease(AD)is an irreversible neurodegenerative disease with a variety of pathogenic factors and complex pathogenesis,so that the disease has a high prevalence and mortality in the world.Although the current diagnosis and treatment equipment and drug research and development keep pace with the times,the current medical technology still can not completely cure the disease,so it is of great significance to explore the pathogenesis and treatment target of AD.The disorder of energy metabolism is one of the characteristic changes in the pathological process of AD.Aerobic glycolysis(AEG)is a special metabolic pathway in the brain,which can rapidly consume glucose to produce energy and substrate for neurons,improve synaptic plasticity,neuroinflammation and oxidative damage,and contribute to the recovery of memory and cognitive function.In recent years,many literatures have reported the mechanism of AEG in AD and the intervention of Tradit Chin Med on this mechanism.The purpose of this paper is to summarize the role of AEG in AD and the related research on the regulation and control of AEG in the treatment of AD by Tradit Chin Med,in order to provide reference and ideas for the prevention and treatment of AD with Tradit Chin Med in the future。
文摘Alzheimer's disease (AD) is an irreversible neurodegenerative disease with a variety of pathogenic factors and complex pathogenesis, so that the disease has a high prevalence and mortality in the world. Although the current diagnosis and treatment equipment and drug research and development keep pace with the times, the current medical technology still can not completely cure the disease, so it is of great significance to explore the pathogenesis and treatment target of AD. The disorder of energy metabolism is one of the characteristic changes in the pathological process of AD. Aerobic glycolysis (AEG) is a special metabolic pathway in the brain, which can rapidly consume glucose to produce energy and substrate for neurons, improve synaptic plasticity, neuroinflammation and oxidative damage, and contribute to the recovery of memory and cognitive function. In recent years, many literatures have reported the mechanism of AEG in AD and the intervention of Tradit Chin Med on this mechanism. The purpose of this paper is to summarize the role of AEG in AD and the related research on the regulation and control of AEG in the treatment of AD by Tradit Chin Med, in order to provide reference and ideas for the prevention and treatment of AD with Tradit Chin Med in the future.
文摘Composting as a solution to the increasing generation of municipal solid waste (MSW), also contribute to GHGs emission when not controlled and could lack some basic nutrients, especially nitrogen. This study assessed the split-additions of nitrogen-rich substrate to composting materials and their effect on GHGs emissions as well as the quality of the composts. Nitrogen-rich substrates formulated from pig and goat manure were co-composted with MSW for a 12-weeks period by split adding at mesophilic (˚C) and thermophilic (>50˚C) stages in five different treatments. Representative samples from the compost were taken from each treatment for physicochemical, heavy metals and bacteriological analysis. In-situ CH<sub>4</sub>, CO<sub>2</sub>, N<sub>2</sub>O gas emissions were also analyzed weekly during composting. It was observed that all the treatments showed significant organic matter decomposition, reaching thermophilic temperatures in the first week of composting. The absence affects the suitable agronomic properties. All nitrogen-rich substrate applied at thermophilic stage (Treatment two) recorded the highest N, P and K concentrations of 1.34%, 0.97% and 2.45%, respectively with highest nitrogen retention. In terms of GHG emissions, CO<sub>2</sub> was highest at the thermophilic stage when N-rich substrate was added in all treatment, while CH<sub>4</sub> was highest in the mesophilic stage with N-rich substrate addition. N<sub>2</sub>O showed no specific trend in the treatments. Split addition of the N-rich substrate for co-composting of MSW produced compost which is stable, has less nutrient loss and low GHG emissions. Split addition of a nitrogen-rich substrate could be an option for increasing the fertilizer value of MSW compost.
基金supported by the National Natural Science Foundation of China (No. 21605060 )the Key Scientific Research Project of Colleges and Universities in Henan Province (No. 20A610006 )。
文摘Current knowledge about the transformation of total mercury and methylmercury(Me Hg) in aerobic composting process is limited. In this study, the composition and transformation of mercury and dissovled organic matter(DOM) in aerobic composting process of municipal sewage sludge were were comprehensively characterized, and the differences among the three C/N ratio(20, 26 and 30) were investigated. The main form of mercury in C/N 20 and 26 was organo-chelated Hg(F3, 46%-60%);while the main form of mercury in C/N 30 was mercuric sulfide(F5, 64%-70%). The main component of DOM in C/N 20 and 26 were tyrosine-like substance(C1, 53%-76%) while the main fractions in C/N 30 were tyrosine-like substance(C1, 28%-37%) and fulvic-like substance(C2, 17%-39%). The mercury and DOM varied significantly during the 9 days composting process. Compared to C/N 20 and 26, C/N 30 produced the less Me Hg after aerobic composting process, with values of 658%(C/N 20), 1400%(C/N 26) and 139%(C/N 30) of the initial, respectively. Meanwhile, C/N 30 produced the best compost showed greater degree of DOM molecular condensation and humification. Hg fraction had been altered by DOM, as indicated by a significant correlation between mercury species and DOM components. Notably, C/N 30 should be used as an appropriate C/N ratio to control the methylation processes of mercury and degration of DOM.
基金supported by the National Key Research and Development Program of China(Grant No.2019YFC1906401)the Open Project of State Key Laboratory of Urban Water Resources and Environment,Harbin Institute of Technology,China(No.QAK201904).
文摘Antibiotic resistance genes(ARGs)have been diffusely detected in several kinds of organic solid waste,such as livestock manure,sludge,antibiotic fermentation residues,and food waste,thus attracting great attention.Aerobic composting,which is an effective,harmless treatment method for organic solid waste to promote recycling,has been identified to also aid in ARG reduction.However,the effect of composting in removing ARGs from organic solid waste has recently become controversial.Thus,this article summarizes and reviews the research on ARGs in relation to composting in the past 5 years.ARGs in organic solid waste could spread in different environmental media,including soil and the atmosphere,which could widen environmental risks.However,the conventional composting technology had limited effect on ARGs removal from organic solid waste.Improved composting processes,such as hyperthermophilic temperature composting,could effectively remove ARGs,and the HGT of ARGs and the microbial communities are identified as vital influencing factors.Currently,during the composting process,ARGs were mainly affected by three response pathways,(Ⅰ)“Microenvironment-ARGs”;(Ⅱ)“Microenvironment-microorganisms-ARGs”;(Ⅲ)“Microorganisms-horizontal gene transfer-ARGs”,respectively.Response pathway Ⅱ had been studied the most which was believed that microbial community was an important factor affecting ARGs.In response pathway Ⅲ,mainly believed that MGEs played an important role and paid less attention to eARGs.Further research on the role and impact of eARGs in ARGs may be considered in the future.It aims to provide support for further research on environmental risk control of ARGs in organic solid waste.
基金supported by the National Natural Science Foundation of China (No. 41275161)the National Science and Technology Support Program (No. 2012BAD14B01)+1 种基金the National Natural Science Foundation of China (NSFC) (No. 41275161)the Ministry of Science and Technology of the People's Republic of China (MOST) (No. 2012BAD14B01) for financing the projects
文摘The effects of adding a bulking agent and chemically pretreating municipal kitchen waste before aerobic composting were studied using a laboratory-scale system. The system used20-L reactors and each test lasted 28 days. The objective was to decrease NH3 and H2S emissions during composting. The bulking agent, dry cornstalks, was mixed with the kitchen waste to give a mixture containing 15%(wet weight) bulking agent. A combined treatment was also conducted, in which kitchen waste mixed with the bulking agent was pretreated with ferric chloride(FeC l3). Less leachate was produced by the composted kitchen waste mixed with bulking agent than by the kitchen waste alone, when the materials had reached the required maturity. The presence of cornstalks also caused less H2 S to be emitted, but had little impact on the amount of NH3 emitted. The FeC l3 was found to act as an effective chemical flocculant,and its presence significantly decreased the amounts of NH3 and H2S emitted. Kitchen waste mixed with cornstalks and treated with FeC l3 emitted 42% less NH3 and 76% less H2 S during composting than did pure kitchen waste.
文摘Spent Coffee Ground (SCG) is characterized by high organic content, in the form of insoluble polysaccharides bound and phenol compounds. Phenol compounds are toxic to nature and <span style="font-family:Verdana;">are</span><span style="font-family:Verdana;"> a cause of environmental pollution. Composting method of this study is aerobic static batch composting with temperature control with adding activators of some fungi such as </span><i><span style="font-family:Verdana;">Aspergillus sp</span></i><span style="font-family:Verdana;">, and </span><i><span style="font-family:Verdana;">Penicillium sp. </span></i><span style="font-family:Verdana;">The purpose of the research is to fill the research gap from previous studies of spent coffee grounds compost, which requires a long time in composting, so that if it is used directly on the soil and plants, the positive effect also requires a long time. The result of composting for 28 days with this method is that mature compost has black crumb and normal pH, with characteristics of C/N ratio below 10: C1 (7.06), C2 (6.99). This value is far from the control with a C/N ratio of 8.33. Decompose rate of macromolecule are above 40% for lignin and 70% for cellulose. Implementation of compost in radish plants, resulting Germination Index above 80% which indicates that the compost is ripe: control (92.39%), C1 (183.88%), C2 (191.86%). The results of the analysis with FTIR also showed that the compost was mature and stable, and rich in minerals. So, it can be concluded </span><span style="font-family:Verdana;">that</span><span style="font-family:Verdana;"> this composting method can speed up composting time and optimize the results of compost produced.</span>
基金financially supported by the Basic Research Project for Shanxi-Zheda Institute of Advanced Materials and Chemical Engineering (2021SX-AT004)the Shanxi Province Science Foundation for Youths (20210302124348, 202103021223099)the National Natural Science Foundation of China (51778397)。
文摘This study evaluated the bioaugmentation potential of a quinoline-degrading strain Pseudomonas citronellolis LV1 inoculation into activated sludge for treating quinoline wastewater, and results indicated the inoculation of LV1 in aerobic continuous MBBR could substantially improve the quinoline removal performance with an improved removal efficiency of 34% averagely when quinoline was used as the sole carbon and nitrogen source. Additionally, efficient removal of quinoline in enhanced MBBR occurred at the influent p H of 7.0–8.0, hydraulic retention time(HRT) of 24–28 h and influent quinoline concentration of 100–700 mg·L^(-1). High-throughput sequencing analysis indicated that bioaugmentation could increase microbial diversity and shape the microbial community structure. Although the inoculant LV1 did not remain its dominance in stage Ⅲ, bioaugmentation indeed induced the formation of effective microbial community, and the indigenous microbes including Flavobacterium, Pseudoxanthomonas,Pseudomonas, Vermamoeba, Dyadobacter and Sphingomonas might play the key role in quinoline removal.According to the PICRUSt, the enhanced genes encoding aromatic ring-cleavage enzyme, especially for Nheterocyclic ring-cleavage enzymes, could lead to the improved removal performance of quinoline in bioaugmentation stage. Moreover, the enhanced MBBR treated well actual coking wastewater, as indicated by high removal performance of quinoline, phenol and COD.
文摘Objective:To investigate the impact of resistance training and aerobic exercise before doula-assisted delivery on the psychological well-being and labor duration of parturients.Methods:105 cases of parturients who gave birth in our hospital from February 2021 to April 2023 were included in this study.The patients were divided into a control group of 52 cases and an observation group of 53 cases.The patients in the control group received no particular intervention before delivery and only received doula assistance.The patients in the observation group received resistance training,aerobic exercise,and doula assistance prior to giving birth.After delivery,the mothers were observed for 2 hours in the delivery room and then returned to the maternal and infant ward.The observation indicators of the two groups were compared.Results:In comparison to the control group,the observation group exhibited shorter durations in the first,second,and third stages of labor,as well as the total delivery time.Additionally,the amount of postpartum blood loss at 2 hours was smaller in the observation group.The rate of cesarean section was lower,and the rate of vaginal natural delivery was higher in the observation group.Following the intervention,both groups of postpartum women showed decreased SAS and SDS scores compared to before the intervention.Moreover,the observation group had lower scores than the control group.These differences were all statistically significant(P<0.05).Conclusion:Resistance training and aerobic exercise before doula-assisted delivery can effectively improve the psychological state of parturients,shorten labor duration,increase the rate of natural vaginal delivery,and reduce pain and postpartum hemorrhage.
