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Inverse of Rensch’s Rule of Allometry for Sexual Size Dimorphism in Bufo andrewsi
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作者 Lanlan ZHANG Ying JIANG +1 位作者 Li ZHAO Wenbo LIAO 《Asian Herpetological Research》 SCIE CSCD 2023年第1期95-102,I0005,共9页
Difference in body size between males and females(sexual size dimorphism:SSD)and its variation are a common phenomenon in animal kingdom.Rensch’s rule predicts that the degree of SSD variation increases with the enla... Difference in body size between males and females(sexual size dimorphism:SSD)and its variation are a common phenomenon in animal kingdom.Rensch’s rule predicts that the degree of SSD variation increases with the enlarged mean body size when males are larger than females and decreases when females are larger than males.Here,whether the patterns of variations in SSD in the Andrew’s toad(Bufo andrewsi)follow Rensch’s rule was tested using unpublished data from 14 populations and published data from 17 populations.Results show the reduced major axis regression of log10(male size)on log10(female size)across all populations displayed a significant hyperallometric relationship,which was consistent with inverse Rensch’s rule(the degree of SSD increased with enlarged mean body size).SSD could also be explained by sexual age difference(SAD)due to a positive SSD–SAD relationship among all populations.The findings suggest that the occurrence of inverse Rensch’s rule in B.andrewsi is likely to be a result of fecundity selection on increased reproductive investments in larger females. 展开更多
关键词 body size Bufo andrewsi hyperallometric Rensch’s rule sexual size dimorphism
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Zipf’s Law, Benford’s Law, and Pareto Rule
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作者 Oded Kafri 《Advances in Pure Mathematics》 2023年第3期174-180,共7页
From a basic probabilistic argumentation, the Zipfian distribution and Benford’s law are derived. It is argued that Zipf’s law fits to calculate the rank probabilities of identical indistinguishable objects and that... From a basic probabilistic argumentation, the Zipfian distribution and Benford’s law are derived. It is argued that Zipf’s law fits to calculate the rank probabilities of identical indistinguishable objects and that Benford’s distribution fits to calculate the rank probabilities of distinguishable objects. i.e. in the distribution of words in long texts all the words in a given rank are identical, therefore, the rank distribution is Zipfian. In logarithmic tables, the objects with identical 1st digits are distinguishable as there are many different digits in the 2nd, 3rd… places, etc., and therefore the distribution is according to Benford’s law. Pareto 20 - 80 rule is shown to be an outcome of Benford’s distribution as when the number of ranks is about 10 the probability of 20% of the high probability ranks is equal to the probability of the rest of 80% low probability ranks. It is argued that all these distributions, including the central limit theorem, are outcomes of Planck’s law and are the result of the quantization of energy. This argumentation may be considered a physical origin of probability. 展开更多
关键词 Zipf’s Law Benford’s Law Pareto 20 - 80 rule Planck’s Law Max Entropy
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Quantum Algorithm for Mining Frequent Patterns for Association Rule Mining
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作者 Abdirahman Alasow Marek Perkowski 《Journal of Quantum Information Science》 CAS 2023年第1期1-23,共23页
Maximum frequent pattern generation from a large database of transactions and items for association rule mining is an important research topic in data mining. Association rule mining aims to discover interesting corre... Maximum frequent pattern generation from a large database of transactions and items for association rule mining is an important research topic in data mining. Association rule mining aims to discover interesting correlations, frequent patterns, associations, or causal structures between items hidden in a large database. By exploiting quantum computing, we propose an efficient quantum search algorithm design to discover the maximum frequent patterns. We modified Grover’s search algorithm so that a subspace of arbitrary symmetric states is used instead of the whole search space. We presented a novel quantum oracle design that employs a quantum counter to count the maximum frequent items and a quantum comparator to check with a minimum support threshold. The proposed derived algorithm increases the rate of the correct solutions since the search is only in a subspace. Furthermore, our algorithm significantly scales and optimizes the required number of qubits in design, which directly reflected positively on the performance. Our proposed design can accommodate more transactions and items and still have a good performance with a small number of qubits. 展开更多
关键词 Data Mining Association rule Mining Frequent Pattern Apriori Algorithm Quantum Counter Quantum Comparator Grover’s search Algorithm
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Use Chou’s 5-Steps Rule to Predict Remote Homology Proteins by Merging Grey Incidence Analysis and Domain Similarity Analysis 被引量:14
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作者 Weizhong Lin Xuan Xiao +1 位作者 Wangren Qiu Kuo-Chen Chou 《Natural Science》 2020年第3期181-198,共18页
Detecting remote homology proteins is a challenging problem for both basic research and drug development. Although there are a couple of methods to deal with this problem, the benchmark datasets based on which the exi... Detecting remote homology proteins is a challenging problem for both basic research and drug development. Although there are a couple of methods to deal with this problem, the benchmark datasets based on which the existing methods were trained and tested contain many high homologous samples as reflected by the fact that the cutoff threshold was set at 95%. In this study, we reconstructed the benchmark dataset by setting the threshold at 40%, meaning none of the proteins included in the benchmark dataset has more than 40% pairwise sequence identity with any other in the same subset. Using the new benchmark dataset, we proposed a new predictor called “dRHP-GreyFun” based on the grey modeling and functional domain approach. Rigorous cross-validations have indicated that the new predictor is superior to its counterparts in both enhancing success rates and reducing computational cost. The predictor can be downloaded from https://github.com/jcilwz/dRHP-GreyFun. 展开更多
关键词 REMOTE HOMOLOGY PROTEINs Grey Model DOMAIN similarity Chou’s 5-steps rules
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On China's Foreign Trade Development and Linkage with the Customary Rules of International Trade 被引量:1
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作者 Li Siyu,Research Fellow of the InternationalTrade Institute,MOFTEC 《China's Foreign Trade》 1996年第7期7-8,共2页
Although great differences exist between the trade systems of different countries,internationaltrade must go on in line with the customary international trade rules.As China’s economy developsand the socialist market... Although great differences exist between the trade systems of different countries,internationaltrade must go on in line with the customary international trade rules.As China’s economy developsand the socialist market economic system emerges,China is basically qualified to link up withcustomary international trade rules.In the Ninth Five-Year Plan period,China’s reform of its foreigntrade system aims at setting up a trade system that conforms with international trade practice.Forthe purpose,the author of this article suggests that a neutral trade policy should be adopted inaccordance with the international practice since it does not hinder exports,nor restrict imports toan excessive degree. 展开更多
关键词 In On China’s Foreign Trade Development and Linkage with the Customary rules of International Trade mode
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基于动态剩余S-N曲线的线性疲劳寿命预测模型 被引量:1
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作者 张拓 刘坤 +2 位作者 何爱民 孙义忠 石万凯 《重庆大学学报》 CAS CSCD 北大核心 2023年第3期84-93,共10页
为估算结构在变幅载荷下的疲劳寿命,在动态剩余S-N曲线的基础上,结合材料的退化规律,对材料受载过程中的累积疲劳损伤进行了量化,提出了一种预测变幅载荷下线性疲劳损伤预测模型。根据热轧16Mn钢和20Cr2Ni4A标准圆柱齿轮多级载荷下疲劳... 为估算结构在变幅载荷下的疲劳寿命,在动态剩余S-N曲线的基础上,结合材料的退化规律,对材料受载过程中的累积疲劳损伤进行了量化,提出了一种预测变幅载荷下线性疲劳损伤预测模型。根据热轧16Mn钢和20Cr2Ni4A标准圆柱齿轮多级载荷下疲劳寿命试验数据,对提出模型的疲劳寿命预测能力进行了验证。结果表明:基于强度退化的线性疲劳寿命预测模型相对传统Miner法则和材料记忆退化累积模型的预测结果更接近试验结果,具有较高的预测精度。 展开更多
关键词 动态剩余s-N曲线 退化规律 寿命预测 弯曲疲劳试验
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Gly-LysPred: Identification of Lysine Glycation Sites in Protein Using Position Relative Features and Statistical Moments via Chou’s 5 Step Rule
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作者 Shaheena Khanum Muhammad Adeel Ashraf +5 位作者 Asim Karim Bilal Shoaib Muhammad Adnan Khan Rizwan Ali Naqvi Kamran Siddique Mohammed Alswaitti 《Computers, Materials & Continua》 SCIE EI 2021年第2期2165-2181,共17页
Glycation is a non-enzymatic post-translational modification which assigns sugar molecule and residues to a peptide.It is a clinically important attribute to numerous age-related,metabolic,and chronic diseases such as... Glycation is a non-enzymatic post-translational modification which assigns sugar molecule and residues to a peptide.It is a clinically important attribute to numerous age-related,metabolic,and chronic diseases such as diabetes,Alzheimer’s,renal failure,etc.Identification of a non-enzymatic reaction are quite challenging in research.Manual identification in labs is a very costly and timeconsuming process.In this research,we developed an accurate,valid,and a robust model named as Gly-LysPred to differentiate the glycated sites from non-glycated sites.Comprehensive techniques using position relative features are used for feature extraction.An algorithm named as a random forest with some preprocessing techniques and feature engineering techniques was developed to train a computational model.Various types of testing techniques such as self-consistency testing,jackknife testing,and cross-validation testing are used to evaluate the model.The overall model’s accuracy was accomplished through self-consistency,jackknife,and cross-validation testing 100%,99.92%,and 99.88%with MCC 1.00,0.99,and 0.997 respectively.In this regard,a user-friendly webserver is also urbanized to accumulate the whole procedure.These features vectorization methods suggest that they can play a critical role in other web servers which are developed to classify lysine glycation. 展开更多
关键词 Gly-LysPred PseAAC post-translational modification lysine glycation Chou’s 5 step rule position relative features
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Alzheimer’s Disease Diagnosis Based on a Semantic Rule-Based Modeling and Reasoning Approach
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作者 Nora Shoaip Amira Rezk +3 位作者 Shaker EL-Sappagh Tamer Abuhmed Sherif Barakat Mohammed Elmogy 《Computers, Materials & Continua》 SCIE EI 2021年第12期3531-3548,共18页
Alzheimer’s disease(AD)is a very complex disease that causes brain failure,then eventually,dementia ensues.It is a global health problem.99%of clinical trials have failed to limit the progression of this disease.The ... Alzheimer’s disease(AD)is a very complex disease that causes brain failure,then eventually,dementia ensues.It is a global health problem.99%of clinical trials have failed to limit the progression of this disease.The risks and barriers to detecting AD are huge as pathological events begin decades before appearing clinical symptoms.Therapies for AD are likely to be more helpful if the diagnosis is determined early before the final stage of neurological dysfunction.In this regard,the need becomes more urgent for biomarker-based detection.A key issue in understanding AD is the need to solve complex and high-dimensional datasets and heterogeneous biomarkers,such as genetics,magnetic resonance imaging(MRI),cerebrospinal fluid(CSF),and cognitive scores.Establishing an interpretable reasoning system and performing interoperability that achieves in terms of a semantic model is potentially very useful.Thus,our aim in this work is to propose an interpretable approach to detect AD based on Alzheimer’s disease diagnosis ontology(ADDO)and the expression of semantic web rule language(SWRL).This work implements an ontology-based application that exploits three different machine learning models.These models are random forest(RF),JRip,and J48,which have been used along with the voting ensemble.ADNI dataset was used for this study.The proposed classifier’s result with the voting ensemble achieves a higher accuracy of 94.1%and precision of 94.3%.Our approach provides effective inference rules.Besides,it contributes to a real,accurate,and interpretable classifier model based on various AD biomarkers for inferring whether the subject is a normal cognitive(NC),significant memory concern(SMC),early mild cognitive impairment(EMCI),late mild cognitive impairment(LMCI),or AD. 展开更多
关键词 Mild cognitive impairment Alzheimer’s disease knowledge based semantic web rule language reasoning system ADNI dataset machine learning techniques
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Study on Growth Rules and Photosynthetic Physiology of Biennial Container Seedlings and Bare Root Seedlings of Phoebe
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作者 Yongzheng MA Shuhuai HE Yongjun FEI 《Asian Agricultural Research》 2017年第9期59-63,共5页
Transplantation experiment was carried out using biennial container seedlings and bare root seedlings of Phoebe zhennan S. Lee as materials. In the experiment,it measured the growth indicators such as the seedling hei... Transplantation experiment was carried out using biennial container seedlings and bare root seedlings of Phoebe zhennan S. Lee as materials. In the experiment,it measured the growth indicators such as the seedling height,basal diameter,and number of branches and leaves. Besides,it also measured net photosynthetic rate( Pn),transpiration rate( Tr),stomatal conductance( Gs),intercellular CO_2 concentration( Ci) and soluble sugar,soluble protein,malondialdehyde( MDA) content,superoxide dismutase activity and root activity. The results indicated that the growth indicators of the Phoebe container seedlings performed the best in the plant height,basal diameter,and number of branches and leaves; photosynthetic capacity was the strongest,and the fertilization could enhance the photosynthetic capacity of seedlings; soluble sugar,soluble protein content,superoxide dismutase activity and root activity of Phoebe container seedlings were higher than that of bare root seedlings. 展开更多
关键词 Phoebe zhennan s.Lee Growth rules Photosynthetic characteristics Physiological characteristics
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Assessing gestational age of babies: Performance of obstetric ultrasound scan compared to that from the combination of Naegle’s rule and Dubowitz score in the 21st century
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作者 Baba Usman Ahmadu 《Natural Science》 2013年第8期32-35,共4页
Background: Some researchers have suggested that when Naegle’s rule (NR) and Dubowitz score (DS) are combined, it could out-perform obstetric ultrasound scan (USS). Others still believe that obstetric USS alone is st... Background: Some researchers have suggested that when Naegle’s rule (NR) and Dubowitz score (DS) are combined, it could out-perform obstetric ultrasound scan (USS). Others still believe that obstetric USS alone is still effective relative to the combination of NR rule and DS in assessing the gestational age (GA) of babies. Objectives: To determine and compare the GA of babies using obstetric USS, NR and DS;and to provide relevant public health information on obstetric USS in the 21st century. Methods: Subjects were selected using systematic random sampling and the GA of babies was determined using obstetric USS, NR, and DS. Statistical package for social science (SPSS) statistical software version 16, Illinois, Chicago USA was used for all data analysis. Results: Eightyfive mother-baby pairs were studied. Forty-four babies (52%) were males and 41 (48%) females. Sixty four (75%) were term with a mean (SD) BW of 3.02 (0.59) at 95%CI (2.89 -?3.14) kg. The overall mean GA of the babies was 38.49 (2.89) at 95%CI (38.14 -?38.85) weeks. The mean GA using obstetric USS, NR and DS were 38.52 (1.98) at 95%CI (38.14 -?38.99), 38.09 (4.13) at 95%CI (37.20-?38.99) and 38.82 (2.02) at 95%CI (38.39 -?39.26), but comparison of these means was not significant (p = 0.256). Combined mean GA by NR and DS was 38.46 (3.26) at 95%CI (37.96 -?38.95). Comparing this mean with mean GA obtained by obstetric USS was also not significant (p = 0.885). Conclusion: The GA assessments by Obstetric USS, NR and DS were all reliable, and Obstetric USS performed effectively relative to combined NR and DS. 展开更多
关键词 GEsTATIONAL Age Babies OBsTETRIC Ultrasound sCAN Naegle’s rule Dubowitz sCORE Maiduguri NIGERIA
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Stability and stabilization of discrete T-S fuzzy time-delay system based on maximal overlapped-rules group 被引量:1
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作者 Songtao Zhang Xiaowei Zhao Jiantong Zhang 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2016年第1期201-210,共10页
The problems of stability and stabilization for the discrete Takagi-Sugeno(T-S) fuzzy time-delay system are investigated.By constructing a discrete piecewise Lyapunov-Krasovskii function(PLKF) in each maximal overlapp... The problems of stability and stabilization for the discrete Takagi-Sugeno(T-S) fuzzy time-delay system are investigated.By constructing a discrete piecewise Lyapunov-Krasovskii function(PLKF) in each maximal overlapped-rules group(MORG),a new sufficient stability condition for the open-loop discrete T-S fuzzy time-delay system is proposed and proved.Then the systematic design of the fuzzy controller is investigated via the parallel distributed compensation control scheme,and a new stabilization condition for the closed-loop discrete T-S fuzzy time-delay system is proposed.The above two sufficient conditions only require finding common matrices in each MORG.Compared with the common Lyapunov-Krasovskii function(CLKF) approach and the fuzzy Lyapunov-Krasovskii function(FLKF) approach,these proposed sufficient conditions can not only overcome the defect of finding common matrices in the whole feasible region but also largely reduce the number of linear matrix inequalities to be solved.Finally,simulation examples show that the proposed PLKF approach is effective. 展开更多
关键词 模糊时滞系统 LYAPUNOV-KRAsOVsKII泛函 稳定性 离散 线性矩阵不等式 充分条件 并行分布补偿 控制器系统
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A Generalization of Cramer’s Rule
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作者 Hugo Leiva 《Advances in Linear Algebra & Matrix Theory》 2015年第4期156-166,共11页
In this paper, we find two formulas for the solutions of the following linear equation , where is a real matrix. This system has been well studied since the 1970s. It is known and simple proven that there is a solutio... In this paper, we find two formulas for the solutions of the following linear equation , where is a real matrix. This system has been well studied since the 1970s. It is known and simple proven that there is a solution for all if, and only if, the rows of A are linearly independent, and the minimum norm solution is given by the Moore-Penrose inverse formula, which is often denoted by;in this case, this solution is given by . Using this formula, Cramer’s Rule and Burgstahler’s Theorem (Theorem 2), we prove the following representation for this solution , where are the row vectors of the matrix A. To the best of our knowledge and looking in to many Linear Algebra books, there is not formula for this solution depending on determinants. Of course, this formula coincides with the one given by Cramer’s Rule when . 展开更多
关键词 LINEAR EQUATION Cramer’s rule GENERALIZED FORMULA
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A Study of the Effects of Family Precepts,Rules and Ethics on Children’s Education During the Tang Dynasty
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作者 Jin Yingkun Arthur(翻译) 《Contemporary Social Sciences》 2020年第6期83-103,共21页
From the perspectives of the prosperity of the Sui and Tang dynasties,the rise and fall of the aristocrats and the prevalence of the imperial examination,this paper studies the impact of family precepts,rules,and ethi... From the perspectives of the prosperity of the Sui and Tang dynasties,the rise and fall of the aristocrats and the prevalence of the imperial examination,this paper studies the impact of family precepts,rules,and ethics on children’s education.I believe that an important feature of family precepts in the Tang Dynasty was the development of the cultural tradition of poetry and literature study within the family,which promoted virtues like loyalty,filial piety,diligence,frugality and modesty and had a profound influence on future generations.The rise and fall of Tang Dynasty families was closely related to family precepts,rules,ethics,and learning.Famous and respectable families often regarded these traits as important means to maintain the family’s status,which objectively promoted the development of family scholarship and the importance of children’s education in the Tang Dynasty.The concept of learning as a“carry-on treasure”has become a common belief among scholars and has played a positive role in educating Chinese society,enriching our culture,and keeping society in order. 展开更多
关键词 Tang Dynasty family ethics family precepts family rules family learning children’s education
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Combining the Rule of Law with the Rule of Morality——General Secretary Xi Jinping's Important Discourse on the Relationship Between the Rule of Law and Rule by Virtue
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作者 徐显明 LI Kunyan 《The Journal of Human Rights》 2017年第2期103-109,共7页
Key points:Throughout the ages,rule of law has been an indispensable means of governing a state.However,as General Secretary Xi Jinping has pointed out,it is not enough to govern a state by the rule of
关键词 of it or as General secretary Xi Jinping’s Important Discourse on the Relationship Between the rule of Law and rule by Virtue Combining the rule of Law with the rule of Morality rule by is that been on with
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Plotting and application of predominance area diagram of Me-S-O system based on topological rules
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作者 谢富春 尹周澜 +2 位作者 谭军 刘常青 张平民 《Journal of Central South University》 SCIE EI CAS CSCD 2016年第6期1332-1338,共7页
The mathematical topological rule was applied to plot the predominance area diagram.Based on the analysis of the mutually conjugated,only two diagrams were the best topological embryonic graphs to build the predominan... The mathematical topological rule was applied to plot the predominance area diagram.Based on the analysis of the mutually conjugated,only two diagrams were the best topological embryonic graphs to build the predominance area diagram of Me-S-O system.Combined with topological rules and thermodynamic calculation,four relation-diagrams were denoted asαandβstable and unstable plane-topological diagrams,which were plotted for the Pb-S-O system and Zn-S-O system.The results show thatβstable plane-topological diagram of Pb-S-O system andαstable one of Zn-S-O system are in accordance with the traditional predominance area diagram,which indicates that it is feasible to plot the predominance area diagram based on mathematical topological rules.Meanwhile,αunstable plane-topological diagram of Pb-S-O system can elucidate the phenomenon that metallic lead exists in higher oxygen and sulfur pressure area in modern bath smelting furnace.The mathematical topological rules broaden the application scope of the predominance area diagram and enrich the practice of its plotting. 展开更多
关键词 拓扑规则 优势区图 系统 应用 绘图 优势区域图 不稳定 拓扑图
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Women’s Councils:A Practical Exploration on the Construction of Democracy, Autonomy and the Rule of Law at the Grassroots Level
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作者 曲相霏 TONG Xiaomei(译) 《The Journal of Human Rights》 2020年第5期638-656,共19页
The women’s councils are an innovation advocated by the All-China women’s federation for women’s participation in social management and grassroots democracy.They are a beneficial exploration for women to participat... The women’s councils are an innovation advocated by the All-China women’s federation for women’s participation in social management and grassroots democracy.They are a beneficial exploration for women to participate in public affairs according to the law in accordance with Article 2 of the Constitution of the People’s Republic of China,and are a model of"the combination of autonomy,rule of law and rule of virtue."The women’s councils have aroused the enthusiasm of women to participate in public affairs,stimulated their autonomous vitality and creativity,and helped to solve the problems of women’s lack of representation and voice in decision-making.The process of deliberation is also the process of developing the awareness of rights,rules,consultation ability,the concept of the rule of law and even thinking about the rule of law.The women’s councils not only help to protect the rights and interests of women and children and promote women’s development,but also has unique value in enriching grassroots consultative democracy,developing grassroots mass autonomy,building a society ruled by law and promoting the implementation of the Constitution.we should therefore fully affirm,support and perfect the women’s councils so as to make it long-term,standardized and institutionalized. 展开更多
关键词 women’s councils consultative democracy society ruled by law combination of autonomy rule of law and rule of virtue implementation of the Constitution
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基于TRIZ的S型曲线进化法则应用研究综述 被引量:2
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作者 王冰 王理 +1 位作者 陈大明 江洪波 《情报探索》 2023年第1期112-118,共7页
[目的/意义]旨在概述当前基于TRIZ的S型曲线进化法则在国内外的应用现状,阐明发展趋势,推动创新应用,促进技术系统发展。[方法/过程]结合WOS和CNKI的文献数据,阐述了基于TRIZ的S型曲线进化法则的起源及发展、应用领域、具体的应用方向... [目的/意义]旨在概述当前基于TRIZ的S型曲线进化法则在国内外的应用现状,阐明发展趋势,推动创新应用,促进技术系统发展。[方法/过程]结合WOS和CNKI的文献数据,阐述了基于TRIZ的S型曲线进化法则的起源及发展、应用领域、具体的应用方向、使用方法及其未来可拓展的应用内容。[结果/结论]基于TRIZ的S型曲线进化法则是一种模型定量化的方法,主要应用于工程技术领域进行技术成熟度评估、技术生命周期研究和技术进化趋势预测。未来,基于TRIZ的S型曲线进化法则仍然具有进一步改进和完善的潜力,依托于计算机技术的辅助提高实用价值。 展开更多
关键词 TRIZ理论 s型曲线进化法则 技术成熟度 技术生命周期 应用综述
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Democracy on the Road toward the Rule of Law Started from Umbrella Movement
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作者 XUE Yang 《International Journal of Technology Management》 2015年第10期123-125,共3页
关键词 法治建设 运动 民主政治建设 主从 主义 社会
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Design of New Thiadiazole Derivatives with Improved Antidiabetic Activity
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作者 Chiépi Nadège Dominique Dou Georges Stéphane Dembele +5 位作者 Mamadou Guy-Richard Kone Nanou Tiéba Tuo Fandia Konate Adama Niare Panaghiotis Karamanis Nahossé Ziao 《Computational Chemistry》 2023年第3期67-80,共14页
Diabetes is a serious, long-term (or chronic) disease that occurs when a person’s blood sugar levels are high because their body cannot produce enough insulin, or does not produce enough insulin or that it cannot eff... Diabetes is a serious, long-term (or chronic) disease that occurs when a person’s blood sugar levels are high because their body cannot produce enough insulin, or does not produce enough insulin or that it cannot effectively use the insulin it produces. According to the literature, this disease has several causes, but certain types of diabetes such as type 2 diabetes are most closely linked to a metabolic disorder due to abdominal obesity. Thus, the number of individuals with type 2 diabetes is increasing. It is with this in mind that we work to improve human health. The aim of this study is to design new derivatives of 1,3,4-thiadiazole with improved antidiabetic activity by the mathematical model of multiple linear regression (MLR) established previously. The analysis of the effect on the substituents influencing the antidiabetic activity, fourteen (14) new molecules coded CDTH were generated and presenting values of the potential of inhibitory concentration higher than that of the base compound (pIC50 = 2.526). But thirteen (13) of these new compounds belong to the domain of applicability of the MLR model established previously. In addition, the thermodynamic quantities of formation formed at 298K have been calculated. Lipinski’s rule and pharmacokinetic properties proved that five (5) (TH4, TH9, TH10, TH13 and TH14) new molecules can be used as diabetes medicine. 展开更多
关键词 DEsIGN Antidiabetic Activity 1 3 4-Thiadiazole Lipinski’s rule
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Combinations of Right Half-Plane Mappings and Vertical Strip Mappings Convex in the Vertical Direction
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作者 Yulin Cai Zirun She +1 位作者 Fanji Zeng Lu Huang 《Open Journal of Statistics》 2023年第6期941-954,共14页
In this paper, we explore the linear combinations of right half-plane mappings and vertical strip mappings. We demonstrate that the combinations of these harmonic mappings are convex in the vertical direction provided... In this paper, we explore the linear combinations of right half-plane mappings and vertical strip mappings. We demonstrate that the combinations of these harmonic mappings are convex in the vertical direction provided they are locally univalent and sense-preserving. Furthermore, we extend this analysis to a more general case by setting specific conditions. Additionally, we take some common parameters such as  as the dilatation of these harmonic mappings, and prove the sufficient conditions that their combinations are locally univalent and convex in the vertical direction. Several examples are constructed by the Mathematica software to demonstrate our main results. 展开更多
关键词 Harmonic Mapping Linear Combination Cohn’s rules Directional Convexi-ty
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