A series of 3-pyridinyl-6-aryl-l, 2, 4-triazolo[3, 4-b][1, 3, 4]thiadiazoles(PATT) were prepared, the structures were confirmed by IR and H NMR spectra. The results of cyclic 1 voltammetry measurements imply that all ...A series of 3-pyridinyl-6-aryl-l, 2, 4-triazolo[3, 4-b][1, 3, 4]thiadiazoles(PATT) were prepared, the structures were confirmed by IR and H NMR spectra. The results of cyclic 1 voltammetry measurements imply that all these compounds have a higher electron affinity (EA) than 2-(4-biphenyl)-5-(4-tert-butyl phenyl)-1, 3, 4-oxadiazole (PBD) which implies that PATT could be acting as better electron acceptors than widely used electron transporting material PBD.展开更多
A method for selective reaction of 1-aryl-propane-1-ones with 1,2-dihydrxy grop of D-mannitol in the presence of ZnCl2-BF3 Et2O to 1, 2_O-(1-aryl- propylidene )-D-mannitol (1-4 ) is described. The compounds were first...A method for selective reaction of 1-aryl-propane-1-ones with 1,2-dihydrxy grop of D-mannitol in the presence of ZnCl2-BF3 Et2O to 1, 2_O-(1-aryl- propylidene )-D-mannitol (1-4 ) is described. The compounds were first reported and determined by IR, MS, 1H-/13C-NMR spectra.among them the Shae of 1 was further defined by X-ray diffraction展开更多
In order to search for new potent anti-inflammatory and analgesic agents in pyrrolizinones, the title compounds were designed and synthesized. A series of the compounds were prepared with two different synthetic sche...In order to search for new potent anti-inflammatory and analgesic agents in pyrrolizinones, the title compounds were designed and synthesized. A series of the compounds were prepared with two different synthetic schemes. Some of the compounds showed remarkable anti-inflammatory and/or analgesic activities on mice.展开更多
Synthesis of 2-aryl-1-arylmethyl-1H-1,3-benzo[d]imidazoles by the reaction of o-phenylenediamine with substituted aromatic aldehydes in the presence of 1-heptanesulfonic acid sodium salt （10 mol%） at room temperatur...Synthesis of 2-aryl-1-arylmethyl-1H-1,3-benzo[d]imidazoles by the reaction of o-phenylenediamine with substituted aromatic aldehydes in the presence of 1-heptanesulfonic acid sodium salt （10 mol%） at room temperature. The reactions were performed in acetonitrile：water （8：2）. The method was proved to be eco-friendly, convenient and the products were isolated with good yields （82- 90%）.展开更多
A convenient method for one-pot two-step 1,3-dipolar cycloadditon reaction of arylboronic acid, sodium azide followed with terminal alkynes in the presence of 2-pyrrolecarbaldiminato-Cu（Ⅱ） complexes catalyst is rep...A convenient method for one-pot two-step 1,3-dipolar cycloadditon reaction of arylboronic acid, sodium azide followed with terminal alkynes in the presence of 2-pyrrolecarbaldiminato-Cu（Ⅱ） complexes catalyst is reported. Various 1-aryl-1,2,3-triazoles were prepared in 63%-97% yields in water at 30℃ without any additives and avoiding the isolation of unstable aryl azides.展开更多
A series of new type substituted 5-fluorouracil derivatives, 1-aryl-5-fluorouracil (4a-4f), were synthesized via diaryliodonium salts and the structure of the title compound was finally confirmed by IR, UV. H-1-NMR. M...A series of new type substituted 5-fluorouracil derivatives, 1-aryl-5-fluorouracil (4a-4f), were synthesized via diaryliodonium salts and the structure of the title compound was finally confirmed by IR, UV. H-1-NMR. MS and CHN analysis.展开更多
An acid catalyzed oxa-Pictet-Spengler reaction‘on water leading to the synthesis of a variety of l-aryl-6,7-dimethoxyisochro-mans is described.The aqueous chemistry is a much cleaner,efficient,cheaper and simple meth...An acid catalyzed oxa-Pictet-Spengler reaction‘on water leading to the synthesis of a variety of l-aryl-6,7-dimethoxyisochro-mans is described.The aqueous chemistry is a much cleaner,efficient,cheaper and simple method for synthesis.The scope of reactions was extended to thia-Pictet-Spengler reaction to afford the some isothiochromans.展开更多
A series of N1-substituted-3-aryl-4-alkyl-4, 5-dihydro-1H-1-pyrazolethiocarboxamide were prepared from the Mannich bases of aryl ketones in good yields. Some derivatives were found to be active against the cysteine p...A series of N1-substituted-3-aryl-4-alkyl-4, 5-dihydro-1H-1-pyrazolethiocarboxamide were prepared from the Mannich bases of aryl ketones in good yields. Some derivatives were found to be active against the cysteine protease of T.cruzi..展开更多
文摘A series of 3-pyridinyl-6-aryl-l, 2, 4-triazolo[3, 4-b][1, 3, 4]thiadiazoles(PATT) were prepared, the structures were confirmed by IR and H NMR spectra. The results of cyclic 1 voltammetry measurements imply that all these compounds have a higher electron affinity (EA) than 2-(4-biphenyl)-5-(4-tert-butyl phenyl)-1, 3, 4-oxadiazole (PBD) which implies that PATT could be acting as better electron acceptors than widely used electron transporting material PBD.
文摘A method for selective reaction of 1-aryl-propane-1-ones with 1,2-dihydrxy grop of D-mannitol in the presence of ZnCl2-BF3 Et2O to 1, 2_O-(1-aryl- propylidene )-D-mannitol (1-4 ) is described. The compounds were first reported and determined by IR, MS, 1H-/13C-NMR spectra.among them the Shae of 1 was further defined by X-ray diffraction
文摘In order to search for new potent anti-inflammatory and analgesic agents in pyrrolizinones, the title compounds were designed and synthesized. A series of the compounds were prepared with two different synthetic schemes. Some of the compounds showed remarkable anti-inflammatory and/or analgesic activities on mice.
文摘Synthesis of 2-aryl-1-arylmethyl-1H-1,3-benzo[d]imidazoles by the reaction of o-phenylenediamine with substituted aromatic aldehydes in the presence of 1-heptanesulfonic acid sodium salt （10 mol%） at room temperature. The reactions were performed in acetonitrile：water （8：2）. The method was proved to be eco-friendly, convenient and the products were isolated with good yields （82- 90%）.
文摘A convenient method for one-pot two-step 1,3-dipolar cycloadditon reaction of arylboronic acid, sodium azide followed with terminal alkynes in the presence of 2-pyrrolecarbaldiminato-Cu（Ⅱ） complexes catalyst is reported. Various 1-aryl-1,2,3-triazoles were prepared in 63%-97% yields in water at 30℃ without any additives and avoiding the isolation of unstable aryl azides.
文摘A series of new type substituted 5-fluorouracil derivatives, 1-aryl-5-fluorouracil (4a-4f), were synthesized via diaryliodonium salts and the structure of the title compound was finally confirmed by IR, UV. H-1-NMR. MS and CHN analysis.
文摘An acid catalyzed oxa-Pictet-Spengler reaction‘on water leading to the synthesis of a variety of l-aryl-6,7-dimethoxyisochro-mans is described.The aqueous chemistry is a much cleaner,efficient,cheaper and simple method for synthesis.The scope of reactions was extended to thia-Pictet-Spengler reaction to afford the some isothiochromans.
文摘A series of N1-substituted-3-aryl-4-alkyl-4, 5-dihydro-1H-1-pyrazolethiocarboxamide were prepared from the Mannich bases of aryl ketones in good yields. Some derivatives were found to be active against the cysteine protease of T.cruzi..
