To discuss the inhibitory effect of supramolecular azelaic acid(SAZA)and azelaic acid(AZA)on melanin synthesis.The inhibition rate of tyrosinase activity was tested in vitro.Zebrafish embryos were exposed to SAZA and ...To discuss the inhibitory effect of supramolecular azelaic acid(SAZA)and azelaic acid(AZA)on melanin synthesis.The inhibition rate of tyrosinase activity was tested in vitro.Zebrafish embryos were exposed to SAZA and AZA in different proportions.The development of embryo melanin was observed and quantitatively analyzed.The experimental result showed that both AZA and SAZA had inhibitory effect on tyrosinase,with IC_(50) of 8.34 mmol/L for AZA and 6.56 mmol/L for SAZA.Zebrafish embryo is basically normally developed,with no obvious deformity.Both AZA and SAZA can inhibit the production of melanin,and the SAZA has a better effect in the same amount of experiment.In addition,AZA is able to inhibit the tyrosinase activity and melanin production in zebrafish embryos.The SAZA prepared by cyclodextrin inclusion has shown better water solubility and significantly improved compatibility.展开更多
Background: Acne vulgaris is a common disorder affecting 79% - 95% of the adolescent population. The choice of treatment depends on the severity, patients with mild to moderate acne should receive topical therapy such...Background: Acne vulgaris is a common disorder affecting 79% - 95% of the adolescent population. The choice of treatment depends on the severity, patients with mild to moderate acne should receive topical therapy such as azelaic acid. Rising antibiotic drug resistance consequent to the widespread use of topical antibiotics is causing concern and effective non-antibiotic treatments are needed. Objective: To compare the efficacy and side effects of topical azelaic acid cream 20% versus active lotion containing triethyl citrate and ethyl linoleate (TCEL) in treatment of mild to moderate acne vulgaris. Patients and Methods: This single, blinded, comparative, therapeutic study was done in the Department of Dermatology-Baghdad Teaching Hospital, Baghdad, Iraq;from May 2013-July 2014. Scoring of acne was carried out and the patients were examined every 2 weeks for 10 weeks of treatment. One month after stopping drugs, patients were evaluated for drug complications and disease recurrence. Sixty patients fulfilling enrollment criteria were included in this study. Patients were divided into 2 groups: Group A (30 patients) treated twice daily with TCEL lotion and Group B (30 patients) treated twice daily with topical azelaic acid cream 20%. Results: Both topical TCEL lotion and azelaic acid cream were statistically an effective therapy for treatment of mild to moderate acne vulgaris. TCEL lotion was more effective and act earlier than azelaic acid cream starting from 4 weeks of therapy till the end of treatment (after 10 weeks) and even after 4 weeks after stopping the treatment (P-value < 0.04). No systemic side effect for both groups was noted while the following side effects were reported;burning, pruritus and erythema, all these side effects disappeared after 8 weeks from starting treatment. After one month of follow up there was no significant relapse in both groups. Conclusion: The TCEL is non-antibiotic based, it had quicker onset of action and observable improvement of both inflammatory and non-inflammatory acne lesions. Its use would reduce the risk of antibiotic resistance developing within the skin flora.展开更多
文摘To discuss the inhibitory effect of supramolecular azelaic acid(SAZA)and azelaic acid(AZA)on melanin synthesis.The inhibition rate of tyrosinase activity was tested in vitro.Zebrafish embryos were exposed to SAZA and AZA in different proportions.The development of embryo melanin was observed and quantitatively analyzed.The experimental result showed that both AZA and SAZA had inhibitory effect on tyrosinase,with IC_(50) of 8.34 mmol/L for AZA and 6.56 mmol/L for SAZA.Zebrafish embryo is basically normally developed,with no obvious deformity.Both AZA and SAZA can inhibit the production of melanin,and the SAZA has a better effect in the same amount of experiment.In addition,AZA is able to inhibit the tyrosinase activity and melanin production in zebrafish embryos.The SAZA prepared by cyclodextrin inclusion has shown better water solubility and significantly improved compatibility.
文摘Background: Acne vulgaris is a common disorder affecting 79% - 95% of the adolescent population. The choice of treatment depends on the severity, patients with mild to moderate acne should receive topical therapy such as azelaic acid. Rising antibiotic drug resistance consequent to the widespread use of topical antibiotics is causing concern and effective non-antibiotic treatments are needed. Objective: To compare the efficacy and side effects of topical azelaic acid cream 20% versus active lotion containing triethyl citrate and ethyl linoleate (TCEL) in treatment of mild to moderate acne vulgaris. Patients and Methods: This single, blinded, comparative, therapeutic study was done in the Department of Dermatology-Baghdad Teaching Hospital, Baghdad, Iraq;from May 2013-July 2014. Scoring of acne was carried out and the patients were examined every 2 weeks for 10 weeks of treatment. One month after stopping drugs, patients were evaluated for drug complications and disease recurrence. Sixty patients fulfilling enrollment criteria were included in this study. Patients were divided into 2 groups: Group A (30 patients) treated twice daily with TCEL lotion and Group B (30 patients) treated twice daily with topical azelaic acid cream 20%. Results: Both topical TCEL lotion and azelaic acid cream were statistically an effective therapy for treatment of mild to moderate acne vulgaris. TCEL lotion was more effective and act earlier than azelaic acid cream starting from 4 weeks of therapy till the end of treatment (after 10 weeks) and even after 4 weeks after stopping the treatment (P-value < 0.04). No systemic side effect for both groups was noted while the following side effects were reported;burning, pruritus and erythema, all these side effects disappeared after 8 weeks from starting treatment. After one month of follow up there was no significant relapse in both groups. Conclusion: The TCEL is non-antibiotic based, it had quicker onset of action and observable improvement of both inflammatory and non-inflammatory acne lesions. Its use would reduce the risk of antibiotic resistance developing within the skin flora.
