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N[a,b]类中Nevanlinna-Pick插值与Hausdorff矩量问题 被引量:4
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作者 吴化璋 陈公宁 《北京师范大学学报(自然科学版)》 CAS CSCD 北大核心 2002年第3期316-323,共8页
利用Hankel向量方法建立N [a ,b]类中Nevanlinna Pick插值与相关Hausdorff矩量问题解集之间的一一对应 ,从而获得前者问题的可解性准则和解的描述 .
关键词 NP问题 Hankel向量 可解性准则 解集 N[α b]类 Nevanlinna-Pick插值 Hausdorff矩量问题
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S[a,b]类中边界Nevanlinna-Pick插值(Ⅱ) 被引量:1
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作者 吴化璋 《Journal of Mathematical Research and Exposition》 CSCD 北大核心 2004年第3期559-568,共10页
继续作者最近的研究,用所谓的Hankel向量方法建立S[a,b]函数类中带边界插值数据的Nevanlinna-Pick插值问题与[a,b]上的某种带约束条件的Hausdorff矩量问题之间解集之间明确的一一对应关系.通过N[a,b]函数类与S[a,b]函数类之间的联系,从... 继续作者最近的研究,用所谓的Hankel向量方法建立S[a,b]函数类中带边界插值数据的Nevanlinna-Pick插值问题与[a,b]上的某种带约束条件的Hausdorff矩量问题之间解集之间明确的一一对应关系.通过N[a,b]函数类与S[a,b]函数类之间的联系,从而由BNP(N[a,b])问题的可解性准则和解的参数化描述获得BNP(S[a,b)问题的可解性准则和解的参数化表示. 展开更多
关键词 S[a b]类 bNP(S[a b)问题 bNP(N[a b)问题 Hausdorff矩量问题 Hankel向量
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N[a,b]类中边界Nevanlinna-Pick插值(I)
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作者 吴化璋 《Journal of Mathematical Research and Exposition》 CSCD 北大核心 2004年第1期107-118,共12页
用所谓的Hankel向量方法求解N[a,b]函数类中带边界插值数据的Nevanlina-Pick插值(BNP(N[a,b]))问题,并建立BNP(N[a,b])问题与[a,b]上的某种带约束条件的Hausdorff矩量问题之间等价的可解条件以及解之间明确的一一对应关系.这使得当BNP(N... 用所谓的Hankel向量方法求解N[a,b]函数类中带边界插值数据的Nevanlina-Pick插值(BNP(N[a,b]))问题,并建立BNP(N[a,b])问题与[a,b]上的某种带约束条件的Hausdorff矩量问题之间等价的可解条件以及解之间明确的一一对应关系.这使得当BNP(N[a,b])问题有多解时,能通过带约束条件的矩量问题的可解性准则和解获得BNP(N[a,b])问题的可解性准则和解的参数化描述,而在唯一解的情况下,通过BNP(N[a,b])问题解的存在唯一性准则和唯一解来获得带约束条件的矩量问题解的存在唯一性准则和唯一解的表示. 展开更多
关键词 N[a b]类 bNP(N[a b])问题 Hausdorff矩量问题 Hankel向量 角导数 边界Nevanlinna-Pick插值
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Effect of Enhanced Ultraviolet-B Radiation on Photosynthetic Pigments and Flavonoids in the Leaves of Grapevine 被引量:4
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作者 李红娟 周新明 张卫强 《Agricultural Science & Technology》 CAS 2011年第12期1849-1852,共4页
[Objective] The study aimed at investigating the influence of enhanced UV-B radiation on photosynthesis of grapevine.[Method] The seedlings of Cabernet sauvignon were treated with different intensities of UV-B radiati... [Objective] The study aimed at investigating the influence of enhanced UV-B radiation on photosynthesis of grapevine.[Method] The seedlings of Cabernet sauvignon were treated with different intensities of UV-B radiation under outdoor conditions,and then the contents of photosynthetic pigments and flavonoids in leaves were determined by measuring the absorbance of leaves extracts at 663,645,470 and 300 nm,respectively.[Result] The content of photosynthetic pigments in the leaves of grapevine obviously increased with time under the treatments of different enhanced UV-B radiation.Compared with the control,the chlorophyll a,chlorophyll b,total chlorophyll and carotenoid were obviously increased by 5%,2%,4% and 3% in the enhanced UV-B radiation treatment of 10.8 μW/cm2(T1),and in the treatment of 25.6 μW/cm2(T2) the corresponding levels were subsequently increased by 11%,9%,10% and 7% with a significant increase in the content of chlorophyll a.On the other hand,the flavonoids content in the leaves of grapevine were obviously increased by 13%,9% in T1 and T2.[Conclusion] The grapevine has strong adaptability to UV-B radiation,and appropriate enhanced UV-B radiation couldn't decrease the photosynthesis of grapevine leaves. 展开更多
关键词 Ultraviolet-b radiation Grapevine.Photosynthetic pigment Flavonoid
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Phylogenetic Relationships of Monal Pheasants Lophophorus Inferred from Sequences of Mitochondrial Cytochrome b Gene 被引量:13
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作者 詹祥江 张正旺 +1 位作者 吴爱平 陶玉静 《Zoological Research》 CAS CSCD 北大核心 2003年第5期337-342,共6页
The phylogeny of the monal pheasants (Lophophorus) and their relationships to some species of the genera Tragopan,Pucrasia and Ithaginis were studied by comparing mitochondrial cytochrome b (cyt b) nucleotide sequence... The phylogeny of the monal pheasants (Lophophorus) and their relationships to some species of the genera Tragopan,Pucrasia and Ithaginis were studied by comparing mitochondrial cytochrome b (cyt b) nucleotide sequences.The molecular phylogenetic trees show that:①the genus Tragopan and the genus Pucrasia share a common ancestor which is the sister taxon of the ancestor of the genus Lophophorus;②the genus Lophophorus had evolved into two branches:One was the Sclaters Monal;the other included the Chinese Monal and the Himalayan Monal.Considering its molecular phylogeny,distribution patterns and morphological evidences,the genus Lophophorus might originate in the Hengduan mountains region of southwestern China. 展开更多
关键词 Lophophorus PHEASANT PHYLOGENY Cyt b gene
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ROLE OF BIVALENT CATIONS AND CHOLINE IN ATP-INDUCED APOPTOSIS OF HUMAN LYMPHOCYTES WITH P2Z RECEPTORS
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作者 彭黎明 JamesSWiley 《Chinese Medical Sciences Journal》 CAS CSCD 1999年第1期23-30,共8页
The role of bivalent cations and choline in ATP induced apoptosis via P2Z purinoceptor was investigated in human leukemic lymphocytes. In vitro exposure of leukemic lymphocytes with P2Z rec... The role of bivalent cations and choline in ATP induced apoptosis via P2Z purinoceptor was investigated in human leukemic lymphocytes. In vitro exposure of leukemic lymphocytes with P2Z receptors to 1 mmol/L ATP or 0 1 mmol/L benzoylbenzoic ATP(BzATP) for 8 h in the presence of choline, 1 mmol/L Mg 2+ or other bivalent cations, and ATP induced DNA breaks, associated with apoptosis were quantified by TdT assay. We observed that (1) Extracellular Mg 2+ or Ca 2+ stimulated ATP induced DNA fragmentation in a dose dependent manner, and the compatible evidence was provided by the inhibition of ATP induced DNA fragmentation in the present of EGTA or EDTA; (2) ATP induced DNA fragmentation was completely inhibited by 1 mmol/L Zn 2+ ;(3)ATP induced DNA breaks were not affected by Ba 2+ , Sr 2+ , Co 2+ when they were substituted for extracellular Mg 2+ or Ca 2+ ;(4)Choline, an inhibitor of phospholipase D(PLD) stimulated by ATP through P2Z receptor in human lymphocytes, was also a partial inhibitor of ATP induced DNA fragmentation, and the results were confirmed by flow cytometric analysis (FCA); (5)ATP induced DNA fragmentation was completely obliterated when the temperature was lower than 10℃. These results suggest that the endonuclease and PLD may be involved in ATP induced apoptosis in human lymphocytes via P2Z receptor. 展开更多
关键词 P2Z purinoceptor apoptosis bivalent cation
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Sequence polymorphism of two major histocompatibility(MH)classⅡB genes and their association with Vibrio anguillarum infection in half-smooth tongue sole(Cynoglossus semilaevis)
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作者 李春梅 张全启 +7 位作者 于燕 李朔 钟其旺 孙业盈 王志刚 齐洁 翟介明 王旭波 《Chinese Journal of Oceanology and Limnology》 SCIE CAS CSCD 2011年第6期1275-1286,共12页
Major histocompatibility complex (MHC) class II B molecules play an important role in the adaptive immune response in fish. Previous study has reported that two highly polymorphic class II B genes, Cyse-DAB and Cyse... Major histocompatibility complex (MHC) class II B molecules play an important role in the adaptive immune response in fish. Previous study has reported that two highly polymorphic class II B genes, Cyse-DAB and Cyse-DBB exist in half-smooth tongue sole (Cynoglossus semilaevis). In this study, the polymorphism within exon 2 of the class II B genes following bacterial challenge was evaluated. Two hundred C. semilaevis individuals were injected intraperitoneally with Vibrio anguillarum. Muscle tissue from the first 20 dead and 20 of the survivors was collected for genotyping. Sixty alleles from the 40 individuals were isolated, of which 32 belonged to Cyse-DAB and 28 belonged to Cyse-DBB. The rate of dN (non-synonymous substitution) was higher than that of ds (synonymous substitution) in the PBRs (peptide binding residues) of both class I1 B genes. Conversely, the rate of ds was higher than dy in the non-PBRs and the complete exon 2 sequence. Thus, the results suggest that positive selection has occurred in the PBRs and purifying selection in the non-PBRs and exon 2. Thirteen class II B alleles were used to study the association between alleles and resistance to infection. Though not significant, alleles Cyse-DAB* 0601, Cyse-DAB * 0706, and Cyse-DBB*O 101, Cyse-DBB* 1301 were only found in surviving individuals and may represent alleles that have resistance against V. anguillarum infection. Alleles Cyse-DAB*0701 and Cyse-DAB*1301 were significantly more prevalent in dead individuals than in surviving ones and may represent alleles that are associated with increased susceptibility to V. anguillarum infection. 展开更多
关键词 major histocompatibility Cyse-DAb Cyse-Dbb ALLELE Vibrio anguillarum INFECTION
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SUBTYPES OF B LYMPHOCYTES IN PATIENTS WITH AUTOIMMUNE HEMOCYTOPENIA 被引量:3
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作者 Li-min Xing Zong-hong Shao +9 位作者 Rong Fu Hong Liu Jun Shi Jie Bai Mei-feng Tu Hua-quan Wang Zhen-zhu Cui Hai-rong Jia Juan Sun Chong-li Yang 《Chinese Medical Sciences Journal》 CAS CSCD 2007年第2期128-131,共4页
Objective To investigate the quantities of bone marrow CD5+ B lymphocytes in the patients with autoimmune hemocytopenia and the relationship between quantities of CD5+ B lymphocytes and clinical or laboratorial parame... Objective To investigate the quantities of bone marrow CD5+ B lymphocytes in the patients with autoimmune hemocytopenia and the relationship between quantities of CD5+ B lymphocytes and clinical or laboratorial parameters. Methods Quantities of CD5+ B lymphocytes in the bone marrow of 14 patients with autoimmune hemolytic anemia (AIHA) or Evans syndrome, 22 immunorelated pancytopenia (IRP) patients, and 10 normal controls were assayed by flow cytometry. The correlation between their clinical or laboratorial parameters and CD5+ B lymphocytes was analyzed. Results The quantity of CD5+ B lymphocytes of AIHA/Evans syndrome (34.64%±19.81%) or IRP patients (35.81%±16.83%) was significantly higher than that of normal controls (12.00%±1.97%, P<0.05). However, there was no significant difference between AIHA/Evans syndrome and IRP patients (P>0.05). In all hemocytopenic patients, the quantity of bone marrow CD5+ B lymphocytes showed significantly negative correlation with serum complement C3 level (r=-0.416, P<0.05). In the patients with AIHA/Evans syndrome, the quantity of bone marrow CD5+ B lymphocytes showed significantly positive correlation with serum indirect bilirubin level (r=1.00, P<0.05). In Evans syndrome patients, the quantity of CD5+ B lymphocytes in bone marrow showed significantly positive correlation with platelet-associated immunoglobulin G (r=0.761, P<0.05) and platelet-associated immunoglobulin M (r=0.925, P<0.05). The quantity of CD5+ B lymphocytes in bone marrow of all hemocytopenic patients showed significantly negative correlation with treatment response (tau-b=-0.289, P<0.05), but had no correlation with colony forming unit-erythroid (r=-0.205, P>0.05) or colony forming unit-granulocyte-macrophage colonies (r=-0.214, P>0.05). Conclusions The quantity of bone marrow CD5+ B lymphocytes in the patients with autoimmune hemocytopenia significantly increases and is correlated with disease severity and clinical response, which suggest that CD5+ B lymphocytes might play an important role in the pathogenesis of autoimmune hemocytopenia. 展开更多
关键词 autoimmune hemocytopenia b lymphocyte SUbTYPE
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Genetic Correction and Hepatic Differentiation of Hemophilia B-specific Human Induced Pluripotent Stem Cells 被引量:2
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作者 何琼 王惠荟 +4 位作者 程涛 袁卫平 马钰波 蒋永平 任志华 《Chinese Medical Sciences Journal》 CAS CSCD 2017年第3期135-144,共10页
Objective To genetically correct a disease-causing point mutation in human induced pluripotent stem cells (iPSCs) derived from a hemophilia B patient. Methods First, the disease-causing mutation was detected by ... Objective To genetically correct a disease-causing point mutation in human induced pluripotent stem cells (iPSCs) derived from a hemophilia B patient. Methods First, the disease-causing mutation was detected by sequencing the encoding area of human coagulation factor IX (F IX) gene. Genomic DNA was extracted from the iPSCs, and the primers were designed to amplify the eight exons of F IX. Next, the point mutation in those iPSCs was genetically corrected using CRISPR/Cas9 technology in the presence of a 129-nucleotide homologous repair template that contained two synonymous mutations. Then, top 8 potential off-target sites were subsequently analyzed using Sanger sequencing. Finally, the corrected clones were differentiated into hepatocyte-like cells, and the secretion of F IX was validated by immunocytochemistry and ELISA assay.Results The cell line bore a missense mutation in the 6th coding exon (c.676 C〉T) of F IX gene. Correction of the point mutation was achieved via CRISPR/Cas9 technology in situ with a high efficacy at about 22% (10/45) and no off-target effects detected in the corrected iPSC clones. F IX secretion, which was further visualized by immunocytochemistry and quantified by ELISA in vitro, reached about 6 ng/ml on day 21 of differentiation procedure. Conclusions Mutations in human disease-specific iPSCs could be precisely corrected by CRISPR/Cas9 technology, and corrected cells still maintained hepatic differentiation capability. Our findings might throw a light on iPSC-based personalized therapies in the clinical application, especially for hemophilia B. 展开更多
关键词 hemophilia b human induced pluripotent stem cells CRISPR/Cas9 genetic correction hepatic differentiation
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Spatio-temporal distribution of earthquake occurrence in Eastern Himalaya and vicinity(26°N-31°N and 87°E-98°E)based on b-value and fractal dimension 被引量:1
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作者 Ram Krishna Tiwari Harihar Paudyal Daya Shanker 《Applied Geophysics》 SCIE CSCD 2022年第3期458-469,472,共13页
This study investigates the spatial and temporal variation of fractal dimension and b-value for the eastern part of the Himalaya and adjoining area(26°N–31°N and 87°E–98°E).The analysis is carrie... This study investigates the spatial and temporal variation of fractal dimension and b-value for the eastern part of the Himalaya and adjoining area(26°N–31°N and 87°E–98°E).The analysis is carried out on the earthquake dataset of 1373 events(Mc=4.0)by sliding window technique for the period 1964 to 2020.The region is divided into three sub regions A(87°E–92°E),B(92°E–94°E)and C(94°E–98°E).The b-value computed for the region A comprising eastern Nepal is smaller compared to other two regions which infers the possible high stress and asperities in the region.High spatial fractal dimension(Dc>1.5)and low temporal fractal dimension(Dt<0.31)are computed for the regions.High spatial fractal dimension may indicate that fractures generating earthquakes are approaching a 2D structure and low temporal fractal dimension implies high clustering of earthquake’s epicenters.The b value shows a weak negative correlation with Dc for regions A and C while a weak positive correlation is observed for the region B.Based on b-value and fractal dimension,this study explains the frequency of earthquakes and heterogeneity of the seismogenic structure in this part of the Himalaya. 展开更多
关键词 Eastern Himalaya FAULT b-VALUE fractal dimension earthquake clustering
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The Taxonomic Status of Gymnura bimaculata and G. japonica: Evidence from Mitochondrial DNA Sequences
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作者 Anglv Shen Chunyan Ma Yong Ni Zhaoli Xu Lingbo Ma 《Journal of Life Sciences》 2012年第1期9-13,共5页
Japanese butterfly ray Gymnura japonica from twinspot butterfly ray G. bimaculata based on a pair of white spots behind eyes or not, which was not reliable. To clarify the taxonomic status of G. japonica and G. bimacu... Japanese butterfly ray Gymnura japonica from twinspot butterfly ray G. bimaculata based on a pair of white spots behind eyes or not, which was not reliable. To clarify the taxonomic status of G. japonica and G. bimaculata, the nucleotide variation between the two butterfly rays was examined using mitochondrial DNA sequence comparisons. Approximately 585 bp of 16S ribosomal RNA (rRNA) and 1,128 bp cytochrome b (cyt b) genes were sequenced from representatives of two butterfly rays species in East China Sea. The results showed that there were the same sequences of 16S rRNA gene between two butterfly rays; six sites were variable among two butterfly rays of cyt b genes, the proportion of polymorphie loci was 0.53%, and two haplotypes were defined which genetic distance was 0.5%. Combined with the morphological character and the analysis of mtDNA sequence indicated that twinspot butterfly ray G. bimaculata was a synonym of Japanese butterfly ray G. japonica. 展开更多
关键词 16S rRNA cyt b morphological character taxonomic status butterfly ray.
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论蔗糖衍生物结构与甜度的相互关系 被引量:5
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作者 郑建仙 饶志娟 贾呈祥 《食品科学》 EI CAS CSCD 北大核心 2003年第5期29-33,共5页
蔗糖含有三个第一类羟基和五个第二类羟基,其甜度与分子上的八个羟基密切相关。使用高度亲油性氯原子,取代蔗糖分子的葡糖基和果糖基上特殊位置的羟基,可以使蔗糖甜味明显增强,这些特殊位置包括C-4、C-1'、C-4'和C-6',而C-... 蔗糖含有三个第一类羟基和五个第二类羟基,其甜度与分子上的八个羟基密切相关。使用高度亲油性氯原子,取代蔗糖分子的葡糖基和果糖基上特殊位置的羟基,可以使蔗糖甜味明显增强,这些特殊位置包括C-4、C-1'、C-4'和C-6',而C-6上的取代则可能导致甜味降低甚至产生苦味。高甜度蔗糖衍生物的分子结构具有很强立体专一性,研究蔗糖衍生物的结构-甜度之间关系,具有十分重要的意义。目前,AH-B-γ理论和多点结合(MPA)理论都被用来解释蔗糖衍生物等甜味分子的甜味机理。 展开更多
关键词 蔗糖衍生物 甜度 分子结构 AH-b-γ理论 多点结合理论 甜味机理
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Transcriptome analysis differentially expressed genes with total carotenoid contents in pearl oyster(Pinctada fucata martensii)
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作者 LIU Yong YANG Xiuyan +3 位作者 LEI Chao LI Junhui YANG Chuangye DENG Yuewen 《Marine Science Bulletin》 2022年第1期56-71,共16页
Differentially expressed genes(DEGs)between individuals with high(HC)and low(LC)total carotenoid content(TCC)were sampled from a selected line of Pinctada fucata martensii with black shell in the prismatic layer.The e... Differentially expressed genes(DEGs)between individuals with high(HC)and low(LC)total carotenoid content(TCC)were sampled from a selected line of Pinctada fucata martensii with black shell in the prismatic layer.The expression levels of candidate genes were verified by qRT-PCR.Targeted resequencing was used to detect SNPs in a candidate gene,PmSR-BI.The association of TCC with SNPs in PmSR-BI was determined.Results showed that a total of 1025 DEGs were identified between HC and LC.The expression levels of the candidate gene PmSR-BI in HC were higher than those in LC.Seven SNPs in the exon and eight SNPs in the 5′regulatory regions of PmSR-BI were found.Association analysis showed that one SNP in the exon and two SNPs in the 5′regulatory regions of PmSR-BI were significantly associated with the TCC(P<0.05).All SNPs of PmSR-BI were divided into four blocks.CC haplotype in Block 1 and AG haplotype in Block 3 were significantly higher than other haplotypes.These results help elucidate the mechanism underlying carotenoid metabolism and develop marker-assisted breeding design in the species. 展开更多
关键词 Pinctada fucata martensii Total carotenoid content Scavenger Receptors Class b Type SNP markers
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鄂北工程总体布局及主要技术问题 被引量:1
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作者 陈长江 刘家明 《中国水利》 2017年第22期5-8,共4页
根据鄂北地区水资源配置工程的实际情况,确定了工程总体布局原则,对引水线路的选择、引水线路及建筑物的布置、调蓄工程布置和分水口门布置进行了总体布局,提出了工程主要解决的技术难题,并总结了为解决这些技术难题所采用的多项新技术... 根据鄂北地区水资源配置工程的实际情况,确定了工程总体布局原则,对引水线路的选择、引水线路及建筑物的布置、调蓄工程布置和分水口门布置进行了总体布局,提出了工程主要解决的技术难题,并总结了为解决这些技术难题所采用的多项新技术、新工艺、新材料,可为类似工程提供借鉴。 展开更多
关键词 院鄂北地区水资源配置工程 总体布局 技术方案
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Moment inequalities for the partial sums of random variables 被引量:9
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作者 杨善朝 《Science China Mathematics》 SCIE 2001年第1期1-6,共6页
This paper discusses the conditions under which Rosenthal type inequality is obtained from M-Z-B type inequality. And M-Z-B type inequality is proved for a wide class of random variables. Hence Rosenthal type inequali... This paper discusses the conditions under which Rosenthal type inequality is obtained from M-Z-B type inequality. And M-Z-B type inequality is proved for a wide class of random variables. Hence Rosenthal type inequalities for some classes of random variables are obtained. 展开更多
关键词 partial sum M-Z-b type inequality Rosenthal type inequality
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Chimera formation of platelet GPⅡb Bak a/b by intrauterine transplantation of fetal liver stem cells
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作者 陈方平 解勤之 +3 位作者 蹇在伏 张新华 张玲娜 吴新华 《Chinese Medical Journal》 SCIE CAS CSCD 2001年第7期4-7,101,共5页
Abstract:Objective To investigate whether artificial heterozygous chimeras of platelets can be established by intrauterine transplantation of fetal liver stem cells and evaluate its potential use for the treatment of ... Abstract:Objective To investigate whether artificial heterozygous chimeras of platelets can be established by intrauterine transplantation of fetal liver stem cells and evaluate its potential use for the treatment of Glanzmann thrombasthenia.Methods Platelet glycoprotein (GP) Ⅱb Bak a/b (or GPⅡb Ⅰle843Ser) was used as a genetic marker. A homozygous 16-week-old Bak a/a fetus (as donor) and a homozygous 16.5-week-old Bak b/b fetus (as recipient) were screened from 42 pregnant women hospitalized for abortion. PCR with allele specific primers and FOK Ⅰ digestion based on PCR products were used. Aborted donor fetal liver cell suspensions were prepared and intrauterine transplantation was carried out by infusion of 4?ml fetal liver cells (22×105) into the recipient umbilical vein under ultrasonic visualization.Results At gestation termination (abortion), 21 days after transplantation, chimera GPⅡb Bak a/b of the recipient were detected by FOK 1 digestion based on PCR from DNA and RT-PCR from platelet RNA. Conclusion Intrauterine transplantation of fetal liver cell may provide an effective way for curing GT or other inherited diseases. 展开更多
关键词 platelet GPⅡb bak a/b · artificial chimera · human fetal liver stem cells · intrauterine transplantation
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Studies on abacavir-induced hypersensitivity reaction:a successful example of translation of pharmacogenetics to personalized medicine 被引量:3
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作者 GUO YongLi SHI LeMing +3 位作者 HONG HuiXiao SU ZhenQiang FUSCOE James NING BaiTang 《Science China(Life Sciences)》 SCIE CAS 2013年第2期119-124,共6页
Abacavir is an effective nucleoside analog reverse transcriptase inhibitor used to treat human immunodeficiency virus(HIV) infected patients.Its main side effect is hypersensitivity reaction(HSR).The incidence of the ... Abacavir is an effective nucleoside analog reverse transcriptase inhibitor used to treat human immunodeficiency virus(HIV) infected patients.Its main side effect is hypersensitivity reaction(HSR).The incidence of the HSR is associated with ethnicity among patients exposed to abacavir,and retrospective and prospective studies show a significantly increased risk of abacavir-induced HSR in human leukocyte antigen(HLA)-B*57:01-carrying patients.Immunological studies indicated that abacavir interacts specifically with HLA-B*57:01 and changed the binding specificity between the HLA molecule and the HLA-presented endogenous peptide repertoire,leading to a systemic autoimmune reaction.HLA-B*57:01 screening,combined with patch testing,had clinically predictive value and cost-effective impact in reducing the incidence of abacavir-induced HSR regardless of the HLA-B*57:01 prevalence in the population.Therefore,the US Food and Drug Administration(FDA) and international HIV treatment guidelines recommend a routine HLA-B*57:01 screening prior to abacavir treatment to decrease false positive diagnosis and prevent abacavir-induced HSR.The studies of abacavir-induced HSR and the implementation of the HLA-B*57:01 screening in the clinic represent a successful example of the use of pharmacogenetics for personalized diagnosis and therapy. 展开更多
关键词 personalized medicine PHARMACOGENETICS drug safety AbACAVIR hypersensitivity reaction (HSR) HLA-b*57:01 HLA-b*57-01 screening
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Classification of EEG-based single-trial motor imagery tasks using a B-CSP method for BCI 被引量:5
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作者 Zhi-chuan TANG Chao LI +2 位作者 Jian-feng WU Peng-cheng LIU Shi-wei CHENG 《Frontiers of Information Technology & Electronic Engineering》 SCIE EI CSCD 2019年第8期1087-1099,共13页
Classifying single-trial electroencephalogram(EEG)based motor imagery(MI)tasks is extensively used to control brain-computer interface(BCI)applications,as a communication bridge between humans and computers.However,th... Classifying single-trial electroencephalogram(EEG)based motor imagery(MI)tasks is extensively used to control brain-computer interface(BCI)applications,as a communication bridge between humans and computers.However,the low signal-to-noise ratio and individual differences of EEG can affect the classification results negatively.In this paper,we propose an improved common spatial pattern(B-CSP)method to extract features for alleviating these adverse effects.First,for different subjects,the method of Bhattacharyya distance is used to select the optimal frequency band of each electrode including strong event-related desynchronization(ERD)and event-related synchronization(ERS)patterns;then the signals of the optimal frequency band are decomposed into spatial patterns,and the features that can describe the maximum differences of two classes of MI are extracted from the EEG data.The proposed method is applied to the public data set and experimental data set to extract features which are input into a back propagation neural network(BPNN)classifier to classify single-trial MI EEG.Another two conventional feature extraction methods,original common spatial pattern(CSP)and autoregressive(AR),are used for comparison.An improved classification performance for both data sets(public data set:91.25%±1.77%for left hand vs.foot and84.50%±5.42%for left hand vs.right hand;experimental data set:90.43%±4.26%for left hand vs.foot)verifies the advantages of the B-CSP method over conventional methods.The results demonstrate that our proposed B-CSP method can classify EEG-based MI tasks effectively,and this study provides practical and theoretical approaches to BCI applications. 展开更多
关键词 Electroencephalogram(EEG) Motor imagery(MI) Improved common spatial pattern(b-CSP) Feature extraction CLASSIFICATION
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Single stage management of Gustilo type Ⅲ A/B tibia fractures: Fixed with nail & covered with fasciocutaneous flap
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作者 G.I. Nambi Abhijeet Ashok Salunke +5 位作者 S.G.Thirumalaisamy V. Lenin Babu K. Baskaran T. Janarthanan K. Boopathi Yong Sheng Chen 《Chinese Journal of Traumatology》 CAS CSCD 2017年第2期99-102,共4页
Purpose: To evaluate the role of immediate and definitive management of Gustilo type Ⅲ A/B tibia fractures with intramedullary nailing and fasciocutaneous flap. Methods: From August 2010 to July 2012, 22 patients w... Purpose: To evaluate the role of immediate and definitive management of Gustilo type Ⅲ A/B tibia fractures with intramedullary nailing and fasciocutaneous flap. Methods: From August 2010 to July 2012, 22 patients with Gustilo Grade Ⅲ A/B tibia fractures were managed with a single stage treatment of ipsilateral fasciocutaneous flap & reamed intramedullary nailing and were included in the study. The severity of the injury was calculated with Ganga Hospital injury severity score. Results: The mean age of patients was 41 years and the follow-up time ranged from six months to one year. Among the 22 patients, 73% were type Ⅲ B fractures with upper leg involved in 55% of them. The time interval from injury to completion of surgery was 8 14 h. The incidence of bone infection requiring secondary procedure was 9%; the major and minor soft tissue complication rate was 9% and 14% respectively. The limb salvage rate was 100%. Conclusion: Multidisciplinary management of severe lower limb trauma is important and provides good outcomes, lntramedullary nailing and immediate flap fixation can achieve early bone union and good soft tissue coverage, leading to good outcomes in patient with Grade Ⅲ A & B tibia fractures. 展开更多
关键词 Tibial fractures openFracture fixation intramedullaryFasciocutaneous flapGustilo type A/b
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Estimates of Soil Organic Carbon Stocks in Zhejiang Province of China Based on 1:50000 Soil Database Using the PKB Method 被引量:2
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作者 ZHI Jun-Jun JING Chang-Wei +2 位作者 LIN Sheng-Pan ZHANG Cao WU Jia-Ping 《Pedosphere》 SCIE CAS CSCD 2015年第1期12-24,共13页
Soil organic carbon(SOC) is an important component of farming systems and global carbon cycle. Accurately estimating SOC stock is of great importance for assessing soil productivity and modeling global climate change.... Soil organic carbon(SOC) is an important component of farming systems and global carbon cycle. Accurately estimating SOC stock is of great importance for assessing soil productivity and modeling global climate change. A newly built 1:50 000 soil database of Zhejiang Province containing 2 154 geo-referenced soil profiles and a pedological professional knowledge-based(PKB) method were used to estimate SOC stock up to a depth of 100 cm for the Province. The spatial patterns of SOC stocks stratified by soil types,watershed(buffer analysis), topographical factors, and land use types were identified. Results showed that the soils in Zhejiang covered an area of 100 740 km2 with a total SOC stock of 831.49 × 106 t and a mean SOC density of 8.25 kg m-2, excluding water and urban areas. In terms of soil types, red soils had the highest SOC stock(259.10 × 106t), whereas mountain meadow soils contained the lowest(0.15 × 106t). In terms of SOC densities, the lowest value(5.11 kg m-2) was found in skel soils, whereas the highest value(45.30 kg m-2) was observed in mountain meadow soils. Yellow soils, as a dominant soil group, determined the SOC densities of different buffer zones in Qiantang River watershed because of their large area percentage and wide variation of SOC density values.The area percentages of various soil groups significantly varied with increasing elevation or slope when overlaid with digital elevation model data, thus influencing the SOC densities. The highest SOC density was observed under grassland, whereas the lowest SOC density was identified under unutilized land. The map of SOC density(0–100 cm depth) and the spatial patterns of SOC stocks in the Province would be helpful for relevant agencies and communities in Zhejiang Province, China. 展开更多
关键词 ELEVATION pedological professional knowledge-based method sampling depth SLOPE SOC density soil groups
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