Five benzamide deriatives containing capsaicin were synthesized which have similar structures to capsaicin. Their yield was high. The monomers synthesized were characterized by IR, 1H NMR and MS spectroscopy. Cha-ract...Five benzamide deriatives containing capsaicin were synthesized which have similar structures to capsaicin. Their yield was high. The monomers synthesized were characterized by IR, 1H NMR and MS spectroscopy. Cha-racterization data are in agreement with the proposed structures of the products. These five compounds exhibit bacterial inhibition and N-[4-hydroxy-2-methyl-5-（methylthio）benzyl]benzamide（HMMBBA）, for instance, shows that the minimal inhibitory concentrations（MIC） of HMMBBA are 0.125 and 0.25 mg/mL on Staphyloccocus aureus and Escherichia coli, respectively. A static test site was set up in the eighth harbor to investigate the antifouling effectiveness of the five new antifoulants. Five-month exposure experiments were performed on sets of panels coated with each of antifouling coatings, and the results were compared to that of the test panel without antifouling coating. Test boards with antifouling coating were covered with just a macroscopic fouling organism such as Balanus. The results of the present paper demonstrate that new antifoulants represent an alternative to the biocidal antifouling paint.展开更多
Five new nervogenic acid derivatives（1-5） have been isolated from Liparis nervosa（Thunb.ex A.Murray） Lindl.Their structures were elucidated on the basis of extensive spectroscopic analysis,including 1D NMR,2D NMR,...Five new nervogenic acid derivatives（1-5） have been isolated from Liparis nervosa（Thunb.ex A.Murray） Lindl.Their structures were elucidated on the basis of extensive spectroscopic analysis,including 1D NMR,2D NMR,and HR-ESI-MS.展开更多
A new series of benzamide derivatives as glucokinase activators （GKAs） were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay. The structure-...A new series of benzamide derivatives as glucokinase activators （GKAs） were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay. The structure-activity relationship （SAR） is discussed. The result shows that compound 12d and 12h have potent activity reference drug RO-28-1675.展开更多
基金Supported by the National High-Tech Research and Development Program of China(Nos.2010AA09Z203, 2010AA065104, 201005028-2)the National Natural Science Foundation of China(No. 51003099)
文摘Five benzamide deriatives containing capsaicin were synthesized which have similar structures to capsaicin. Their yield was high. The monomers synthesized were characterized by IR, 1H NMR and MS spectroscopy. Cha-racterization data are in agreement with the proposed structures of the products. These five compounds exhibit bacterial inhibition and N-[4-hydroxy-2-methyl-5-（methylthio）benzyl]benzamide（HMMBBA）, for instance, shows that the minimal inhibitory concentrations（MIC） of HMMBBA are 0.125 and 0.25 mg/mL on Staphyloccocus aureus and Escherichia coli, respectively. A static test site was set up in the eighth harbor to investigate the antifouling effectiveness of the five new antifoulants. Five-month exposure experiments were performed on sets of panels coated with each of antifouling coatings, and the results were compared to that of the test panel without antifouling coating. Test boards with antifouling coating were covered with just a macroscopic fouling organism such as Balanus. The results of the present paper demonstrate that new antifoulants represent an alternative to the biocidal antifouling paint.
基金supported by the National Natural Science Foundation of China(Nos.21142004,31171695)the New Century Talents Scheme of the Ministry of Education(No. NCET-08-0820)+1 种基金Science and Technology Support Programs of Sichuan Province(No.2013SZ0083)the Fundamental Research Funds for Central Universities(Nos.SWJTU2010ZT09, SWJTU12CX048)
文摘Five new nervogenic acid derivatives（1-5） have been isolated from Liparis nervosa（Thunb.ex A.Murray） Lindl.Their structures were elucidated on the basis of extensive spectroscopic analysis,including 1D NMR,2D NMR,and HR-ESI-MS.
基金financially supported by the National Nature Science Foundation of China(No.30572256)
文摘A new series of benzamide derivatives as glucokinase activators （GKAs） were designed and synthesized, and their activation for glucokinase were evaluated by the preliminary glucokinase activity assay. The structure-activity relationship （SAR） is discussed. The result shows that compound 12d and 12h have potent activity reference drug RO-28-1675.
