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UPLC-Q-TOF-MS法分析枇杷叶的倍半萜苷类化合物 被引量:13
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作者 赵磊 陈剑 +2 位作者 印敏 任冰如 李维林 《中成药》 CAS CSCD 北大核心 2015年第7期1498-1502,共5页
目的采用超高效液相-四级杆-飞行时间串联质谱(UPLC-Q-TOF-MS)技术对分离得到的枇杷叶总倍半萜苷类成分进行定性分析,并对其裂解途径进行研究总结。方法枇杷叶乙醇提取物经大孔树脂、聚酰胺柱色谱和RP-18柱色谱处理后,得到的枇杷叶总倍... 目的采用超高效液相-四级杆-飞行时间串联质谱(UPLC-Q-TOF-MS)技术对分离得到的枇杷叶总倍半萜苷类成分进行定性分析,并对其裂解途径进行研究总结。方法枇杷叶乙醇提取物经大孔树脂、聚酰胺柱色谱和RP-18柱色谱处理后,得到的枇杷叶总倍半萜苷采用Agilent ZORBAX SB-C18色谱柱(4.6 mm×100 mm,1.8μm),甲醇-0.1%甲酸水溶液为流动相进行梯度洗脱,ESI源负离子模式下采集质谱数据。结果从总倍半萜苷中得到5个倍半萜苷类化合物,其二级质谱裂解规律均相同,表现为逐个脱去寡糖链上的糖基,产生特征碎片离子m/z 675、529、383,最后生成m/z 205的特征苷元碎片。结论其中2个倍半萜苷类成分可能是仅在苷元C-6和C-7位上构型有差异的loquatifolin A和6,7-cis-nerolidol-3-O-α-L-rhamnopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→6)]-β-D-glucopyranoside。 展开更多
关键词 枇杷叶 倍半萜苷 UPLC-Q-TOF-MS loquatifolin A 6 7-cis-nerolidol-3-O-α-L-rhamnopyranosyl-(1→4)-α-L-rh-amnopyranosyl-(1→2)--L-rhamnopyranosyl-(1→6)]-β-d-glucopyranoside
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青蕨植物化学成分的研究(英文) 被引量:4
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作者 胡浩斌 郑旭东 《西北植物学报》 CAS CSCD 北大核心 2005年第4期781-785,共5页
从青蕨根部的乙酸乙酯提取物中分离得到4个化合物.通过化学及波谱分析鉴定其结构为:saucerneolD1,dehydrogoniothalamin2,1-acetoxyl-2-piperonyl-6-[6-methoxyl-piperonyl]-3,7-dioxabicyclo-[3,3,0]-octane3and5,5′-dihydroxy-3-meth... 从青蕨根部的乙酸乙酯提取物中分离得到4个化合物.通过化学及波谱分析鉴定其结构为:saucerneolD1,dehydrogoniothalamin2,1-acetoxyl-2-piperonyl-6-[6-methoxyl-piperonyl]-3,7-dioxabicyclo-[3,3,0]-octane3and5,5′-dihydroxy-3-methoxy-6,8,3″,3″-tetramethylpyran-3′,4′flavone-7-O-[β-D-apiofuranosyl-1→6]-β-D-glucopyranoside4.其中化合物4为新化合物,化合物1为首次从该属植物中分离得到. 展开更多
关键词 青蕨 saucerneol D 5 5′-dihydroxy-3-methoxy-6 8 3″ 3″-tetramethylpyran-(3′ 4′)flavone-7-O--D-apiofuranosyl-(1→6)]-β-d-glucopyranoside
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Spirostane Steroidal Saponins from the Undergroud Parts of Tupistra chinensis 被引量:4
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作者 GuangXuWU XiaoYiWEI WeiXinCHEN 《Chinese Chemical Letters》 SCIE CAS CSCD 2005年第7期911-914,共4页
Two new spirostanol saponins, (25S)-spirostane-1β,3β,5β-triol 3-O-β-D-glucopyrano- side 1 and rhodeasapogenin 3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranoside 2, together with a known saponin, rhodeasapogenin... Two new spirostanol saponins, (25S)-spirostane-1β,3β,5β-triol 3-O-β-D-glucopyrano- side 1 and rhodeasapogenin 3-O-β-D-glucopyranosyl-(1 → 4)-β-D-glucopyranoside 2, together with a known saponin, rhodeasapogenin 3-O-β-D-glucopyranoside 3, were isolated from the underground parts of Tupistra chinensis Bak.. Their structures were determined by spectroscopic analysis. 展开更多
关键词 Tupistra chinensis Bak. LILIACEAE steroidal saponins (25S)-spirostane-1β -triol 3- O-β-d-glucopyranoside rhodeasapogenin 3-O-β-d-glucopyranosyl-(1 4)-β-d-glucopyranoside.
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A new flavonoid glucoside from Cassia angustifolia 被引量:3
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作者 Qiu Ping Wu Zhu Ju Wang +2 位作者 Li Ying Tang Mei Hong Fu Yan He 《Chinese Chemical Letters》 SCIE CAS CSCD 2009年第3期320-321,共2页
A new flavonoid glucoside with a known one was isolated from the leaves of Cassia angustifolia. Based on the spectral analysis, including MS, ^1H NMR, ^13C NMR, DEPT, ^1H-1HCOSY, HMQC, HMBC and NOSEY, their chemical s... A new flavonoid glucoside with a known one was isolated from the leaves of Cassia angustifolia. Based on the spectral analysis, including MS, ^1H NMR, ^13C NMR, DEPT, ^1H-1HCOSY, HMQC, HMBC and NOSEY, their chemical structures were determined as kaempferol-3-O-[(6'''-O-trans-sinnapoyt)-β-D-glucopyranosyl (1 → 6)]-β-D-glucopyranoside 1 and apigenin-6,8-di-C-glycoside 2. 展开更多
关键词 Cassia angustifolia Flavonol glucoside Kaempferol-3-O-[ 6'''-O-trans-sinnapoyl)-β-d-glucopyranosyl-(1→6)]-β-d-glucopyranoside
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A new triterpene saponin from Panax japonicus C.A.Meyer var major(Burk.) C.Y.Wu et K.M.Feng 被引量:4
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作者 Hong Zhao Lin Shi +3 位作者 Jia Qing Cao Wei Li Xia Wen Yu Qing Zhao 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第10期1216-1218,共3页
One new Iriterpene saponin was isolated from Panaxjaponicus C. A. Meyer var major (Burk.) C. Y. Wu et K. M. Feng, and established as oleanolic acid 3-O-[β-D-glucopyranosyl-(1 →2)-β-D-glucuronopyranosyl-6'-O-n-... One new Iriterpene saponin was isolated from Panaxjaponicus C. A. Meyer var major (Burk.) C. Y. Wu et K. M. Feng, and established as oleanolic acid 3-O-[β-D-glucopyranosyl-(1 →2)-β-D-glucuronopyranosyl-6'-O-n-butyl ester] which showed mod- erate antitumor activities against the A2780 cells and OVCAR-3 cells. Its structure was established by means of spectral data, particularly NMR, including HSQC and HMBC techniques. 展开更多
关键词 Oleanolic acid 3-O-[β-d-glucopyranosyl-(1 2)-β-D-glucuronopyranosyl-6-O-n-butyl ester] Antitumor Panax japonicus C. A.Meyer vat major (Burk) C Y wu et K. M Feng Triterpene saponin
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A new glycoside from the leaves of Neoalsomitra integrifoliola 被引量:1
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作者 Dong Min Su Jing Qu +5 位作者 You Cai Hu Shi Shan Yu Wen Zhao Tang Yun Bao Liu Shuang Gang Ma De Quan Yu 《Chinese Chemical Letters》 SCIE CAS CSCD 2008年第7期845-848,共4页
A new ionone glycoside (6R,9R)-blumenyl α-L-rhamnopyranosyl-(1 → 6)-β-D-gluco-pyranoside (1), together with a new natural product 2-methoxyl-4-trans-pmpenyl-phenol α-L-rhamnopyranosyl-(1 → 6)-β-D-glucopy... A new ionone glycoside (6R,9R)-blumenyl α-L-rhamnopyranosyl-(1 → 6)-β-D-gluco-pyranoside (1), together with a new natural product 2-methoxyl-4-trans-pmpenyl-phenol α-L-rhamnopyranosyl-(1 → 6)-β-D-glucopyranoside (2), was isolated from the leaves ofNeoalsomitra integrifoliola. Their structures were elucidated by chemical and spectral analysis. Compound 1 showed weak anti-inflammatory and low-level antioxidant activities. 展开更多
关键词 Neoalsomitra integrifoliola 6R 9R)-Blumenyl α-L-rhamnopyranosyl-(1 6)-β-d-glucopyranoside 2-Methoxyl-4-trans-propenyl-phenol α-L-rhamnopyranosyl-(1 6)-β-d-glucopyranoside BIOACTIVITIES
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New Constituents from the Fresh Stems of Opuntia Dillenii 被引量:2
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作者 QIUYing-kun CHENYing-jie +2 位作者 PEIYu-pin MatsudaHisashi YoshikawaMasayuki 《Journal of Chinese Pharmaceutical Sciences》 CAS 2003年第1期1-5,共5页
Aim To study the chemical composition of Opuntia dillenii Haw. Methods Manykinds of chromatogra-phy methods were used in the isolation procedure, while the structures ofisolated compounds were determined on the aids o... Aim To study the chemical composition of Opuntia dillenii Haw. Methods Manykinds of chromatogra-phy methods were used in the isolation procedure, while the structures ofisolated compounds were determined on the aids of NMR and MS spectral analysis. Result Three newcompounds, together with 14 known compounds, were isolated form the 80% ethanolic extract of itsstems. Conclusion The three new compounds, opuntioside Ⅰ (2), 4-ethoxyl-6-hydroxymethyl-α-pyrone(3) and kaempferol 7-O-β-D-glucopyranosyl (1→4)-β-D-glucopyranoside (4), were characterized. 展开更多
关键词 opuntia dillenii opuntioside 4-ethoxyl-6-hydroxymethyl-α-pyrone kaempferol 7- O-D-glucopyranosyl (1→4)-β-d-glucopyranoside
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A new coumarin glycoside from Daphne giraldii
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作者 Juan Su Zhi Jun Wu +5 位作者 Run Hui Liu Yun Heng Shen Chuan Zhang Hui Liang Li Wei Zhang Wei Dong Zhang 《Chinese Chemical Letters》 SCIE CAS CSCD 2007年第7期835-836,共2页
A new coumarin glycoside was isolated from the ethanol extract of the barks of stem of Daphne giraldii Nitsche. Its structure was defined as daphnetin 8-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranoside on the bas... A new coumarin glycoside was isolated from the ethanol extract of the barks of stem of Daphne giraldii Nitsche. Its structure was defined as daphnetin 8-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranoside on the basis of spectral evidences. 展开更多
关键词 Daphne giraldii THYMELAEACEAE Coumarin glycoside Daphnetin 8-O-β-d-glucopyranosyl-(1 6)-β-d-glucopyranoside
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A new phenolic compound from Crinum asiaticum L.
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作者 Qian Sun Wei Dong Zhang +2 位作者 Yun Heng Shen Chuan Zhang Hui Liang Li 《Chinese Chemical Letters》 SCIE CAS CSCD 2008年第4期447-449,共3页
A new phenolic compound was isolated from the ethanol extract of the bulbs of Crinum asiaticum L.var.sinicum Baker.Its structure was defined as 1-(2-hydroxy-4-hydroxymethyl)phenyl-6-O-caffeoyl-β-D-gluco-pyranoside ... A new phenolic compound was isolated from the ethanol extract of the bulbs of Crinum asiaticum L.var.sinicum Baker.Its structure was defined as 1-(2-hydroxy-4-hydroxymethyl)phenyl-6-O-caffeoyl-β-D-gluco-pyranoside on the basis of spectroscopic evidences. 展开更多
关键词 Crinum asiaticum L.var.sinicum baker Amaryllideae Phenolic compound 1-(2-Hydroxy-4-hydroxymethyl)phenyl-6-O-caffeoyl-β-d-glucopyranoside
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UPLC-Q/TOF法同时定性定量分析滇芹药材中主要化学成分 被引量:8
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作者 秦伟瀚 冉继春 +4 位作者 叶良红 花雷 王云红 郭延垒 阳勇 《中草药》 CAS CSCD 北大核心 2018年第15期3576-3582,共7页
目的建立UPLC-Q/TOF法同时定性、定量分析滇芹中主要化学成分。方法采用超高效液相色谱串联飞行时间质谱法进行分析,色谱柱为Agilent Poroshell 120 Hilic,流动相为乙腈-0.1%甲酸水溶液,梯度洗脱,体积流量0.3 m L/min;定性、定量采用Q-... 目的建立UPLC-Q/TOF法同时定性、定量分析滇芹中主要化学成分。方法采用超高效液相色谱串联飞行时间质谱法进行分析,色谱柱为Agilent Poroshell 120 Hilic,流动相为乙腈-0.1%甲酸水溶液,梯度洗脱,体积流量0.3 m L/min;定性、定量采用Q-TOF正负离子全扫描+IDA(信息关联采集)模式。结果利用已建立的筛查数据库将满足质量误差小于5×10-6、同位素分布正确且含有二级碎片的离子作为分析目标化合物,结合软件Formula Finder、Mass Calculators等功能、在线数据库(Human Metabolome Database、Pub Chem、Chemical Book等)及二级碎片裂解规律,共鉴定出23个化合物,滇芹首次发现4个化合物。确定阿魏酸为定量分析指标性成分,其定量、定性离子分别为178和149;阿魏酸检测质量浓度线性范围为1.14~1 140 ng/m L(r=1.000),检测限、定量限分别为0.87、2.91 ng/m L,精密度、稳定性、重复性试验的RSD<2%,加样回收率为98.13%~101.25%(RSD=1.37%,n=5)。结论该方法灵敏度高、重现性好,分析快速、准确、可靠,可用于同时定性、定量检测滇芹药材中主要化学成分;云南滇芹中阿魏酸含量要高于西藏滇芹。 展开更多
关键词 滇芹 UPLC-Q/TOF 阿魏酸 6-(2-methoxyvinyl)-7-methyl-2H-1-benzopyran-2-one 1-O-β-d-glucopyranosyl-1 3-octanediol 2-pentylbutanedioic acid 4 4-dimethylcholesta-8(9) 14-dien--ol
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玄参药材中多类型成分的定量分析方法建立及其在脉络宁口服液中的应用 被引量:1
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作者 徐思易 谭亚杰 +2 位作者 唐浩竣 李剑 谭宁华 《中草药》 CAS CSCD 北大核心 2023年第11期3446-3458,共13页
目的建立超高效液相色谱-串联三重四极杆质谱(UPLC-QqQ-MS/MS)方法同时测定玄参Scrophulariae Radix中多类型成分的含量,并将此方法应用于脉络宁口服液(Mailuoning Oral Liquid,MOL),为玄参药材和MOL的质量评价提供依据。方法采用Waters... 目的建立超高效液相色谱-串联三重四极杆质谱(UPLC-QqQ-MS/MS)方法同时测定玄参Scrophulariae Radix中多类型成分的含量,并将此方法应用于脉络宁口服液(Mailuoning Oral Liquid,MOL),为玄参药材和MOL的质量评价提供依据。方法采用Waters HSS T3色谱柱(100 mm×2.1 mm,1.8μm),以0.1%甲酸水溶液和乙腈为流动相进行梯度洗脱。质谱采用电喷雾离子源(electrospray ionization,ESI),在多反应监测模式(multiple reaction monitoring,MRM)下对环烯醚萜苷、苯丙素苷、有机酸和核苷4类成分进行定量分析,结合化学计量学分析评价不同批次样品的质量。结果化学计量学结果表明,不同地区的玄参药材得到了有效区分,其质量差异可能与其生长环境相关。此外,4个年份(2019、2020、2021和2022年)的MOL各自聚成1类,可能是当年使用的药材质量相对稳定使得同一年份的MOL质量更相近;通过正交偏最小二乘-判别分析(orthogonal partial least squares-discriminate analysis,OPLS-DA)进一步筛选出不同年份MOL中异毛蕊花糖苷、对甲氧基肉桂酸、腺苷、1-(3-hydroxy-4-methoxyphenyl)ethyl-3-α-L-rhamnopyranosyl-6-caffeoyl-β-D-glucopyranoside、对羟基苯甲酸、阿魏酸和原儿茶酸7个差异性化学成分。结论该方法特异性强、准确度高且稳定性好,可为MOL中臣药玄参的药材选择及复方整体质量评价提供科学依据。 展开更多
关键词 玄参 脉络宁口服液 质量控制 化学计量学 异毛蕊花糖苷 对甲氧基肉桂酸 腺苷 1-(3-hydroxy-4-methoxyphenyl)ethyl-3-α-L-rhamnopyranosyl-6-caffeoyl-β-d-glucopyranoside 对羟基苯甲酸 阿魏酸 原儿茶酸
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桂枝茯苓胶囊化学成分研究(VI) 被引量:12
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作者 谢雪 张宏达 +6 位作者 温建辉 宋亚玲 王雪晶 赵祎武 黄文哲 王振中 萧伟 《中草药》 CAS CSCD 北大核心 2016年第21期3795-3797,共3页
目的对桂枝茯苓胶囊内容物正丁醇和醋酸乙酯萃取部位进行化学成分研究。方法采用多种色谱方法对桂枝茯苓胶囊内容物的正丁醇和醋酸乙酯萃取部位进行分离纯化,根据理化性质和波谱数据鉴定其结构。结果从醋酸乙酯和正丁醇层分离得到10个... 目的对桂枝茯苓胶囊内容物正丁醇和醋酸乙酯萃取部位进行化学成分研究。方法采用多种色谱方法对桂枝茯苓胶囊内容物的正丁醇和醋酸乙酯萃取部位进行分离纯化,根据理化性质和波谱数据鉴定其结构。结果从醋酸乙酯和正丁醇层分离得到10个化合物,分别鉴定为对羟基苯甲酸(1)、反式邻甲氧基桂皮酸(2)、反式桂皮酸(3)、对香豆酸(4)、2,5-dihydroxy-4-methylaeetophenone(5)、没食子酸乙酯(6);从正丁醇层分离得到4个化合物,分别为香草酸(7)、原儿茶酸(8)、affinoside(9)、benzyl-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside(10)。结论化合物1~10均为首次从该复方中分离得到。 展开更多
关键词 桂枝茯苓胶囊 对香豆酸 2 5-dihydroxy-4-methylacetophenone 原儿茶酸 affinoside benzyl-β-d-glucopyranosyl-(1→6)-β-d-glucopyranoside
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