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A Novel Green Preparation of a, a'-Bis (substituted benzylidene)-cycloalkanones Promoted by FeCl_3 6H-2O in Ionic Liquid 被引量:5
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作者 Xin Ying ZHANG, Xue Sen FAN, Hong Ying NIU, Jian Ji WANGSchool of Chemical and Environmental Sciences, Henan Normal University, Key Laboratory ofEnvironmental Science and Engineering of Henan Education Department,Xinxiang 453002 《Chinese Chemical Letters》 SCIE CAS CSCD 2003年第10期1005-1007,共3页
a, a'-Bis(substituted benzylidene)cycloalkanones were efficiently prepared from cycloalkanones and benzaldehydes in [bmim][BF4] by using iron(III) chloride hexahydrate as a catalyst. It is shown that [bmim][BF4] a... a, a'-Bis(substituted benzylidene)cycloalkanones were efficiently prepared from cycloalkanones and benzaldehydes in [bmim][BF4] by using iron(III) chloride hexahydrate as a catalyst. It is shown that [bmim][BF4] and iron(III) chloride hexahydrate can be quantitatively recovered and be reused effectively for many times. Compared with the known methods, this novel process has the advantage of being an envkonmentally benign process together with good yields and mild reaction conditions. 展开更多
关键词 Ionic liquid a a'-bis(substituted benzylidene)cycloalkanones iron(III) chloride hexahydrate.
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Synthesis of Poly[(3-octanoylpyrrole-2,5-diyl)-p-(N,N-dimethylamino)benzylidene] and Its Properties by Nitrogen Ion Implantation 被引量:1
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作者 ZHANGZhi-gang WUHong-cai +1 位作者 LIUXiao-zeng YIWen-hui 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2005年第2期166-168,共3页
A novel soluble π-conjugated polymer, poly[(3-octanoylpyrrole-2,5-diyl)-p-(N,N-dimethylamino)benzylidene](POPDMABE), was synthesized firstly by the condensation of 3-octanoylpyrrole with para-dimethylaminobenzaldehyd... A novel soluble π-conjugated polymer, poly[(3-octanoylpyrrole-2,5-diyl)-p-(N,N-dimethylamino)benzylidene](POPDMABE), was synthesized firstly by the condensation of 3-octanoylpyrrole with para-dimethylaminobenzaldehyde. The chemical structure of the polymer was characterized by FTIR and 1H NMR spectrometries. The polymer is a potential nonlinear optical(NLO) material. According to the function of optical forbidden band gap(E_g) and photon energy(hν), the optical forbidden band gaps of the polymer before and after ion implantation were calculated. The resonant third-order nonlinear optical properties of POPDMABE before and after ion implantation were also studied by using the degenerate four-wave mixing(DFWM) technique at 532 nm. When the energy is 25 keV and the dose is 2.2×10 17 ions/cm 2, the {polymer′s} optical forbidden band gap is about 1.63 eV which is smaller than that of the non-implanted sample(1.98 eV) and the resonant third-order NLO susceptibility of POPDMABE is about 4.3×10 -7 esu, 1 order of magnitude higher than that of the non-implanted sample(4.1×10 -8 esu). The results show that nitrogen ion implantation is an effective method to improve the resonant third-order NLO property of the polymer. 展开更多
关键词 Poly[(3-octanoylpyrrole-2 5-diyl)-p-(N N-dimethylamino)benzylidene] Ion implantation Optical forbidden band gap Resonant third-order nonlinear optical property Degenerate four-wave mixing technique
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Anticancer efficacy of 3-(4-isopropyl)benzylidene-8-ethoxy,6-methyl,chroman-4-one(SBL-060),a novel,dual,estrogen receptor-Akt kinase inhibitor in acute myeloid leukemia cells
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作者 MESFER AL SHAHRANI PRASANNA RAJAGOPALAN +5 位作者 MOHAMMAD ABOHASSAN MOHAMMAD ALSHAHRANI YASSER ALRAEY REEM MGAHTANI SURESH RADHAKRISHNAN KHLOOD DAGREERY 《Oncology Research》 SCIE 2021年第3期149-157,共9页
Estrogen receptor(ER)αis expressed in a subset of patient-derived acute myeloid leukemia(AML)cells,whereas Akt is predominantly expressed in most types of AML.Targeting AML with dual inhibitors is a novel approach to... Estrogen receptor(ER)αis expressed in a subset of patient-derived acute myeloid leukemia(AML)cells,whereas Akt is predominantly expressed in most types of AML.Targeting AML with dual inhibitors is a novel approach to combat the disease.Herein,we examined a novel small molecule,3-(4-isopropyl)benzylidene-8-ethoxy,6-methyl,chroman-4-one(SBL-060),capable of targeting AML cells by inhibiting ERαand Akt kinase.The chemical properties of SBL-060 were identified by proton nuclear magnetic resonance(^(1)H-NMR),^(13)C-NMR,and mass spectroscopy.In silico docking was performed using an automated protocol with AutoDock-VINA.THP-1 and HL-60 cell lines were differentiated using phorbol 12-myristate 13-acetate.ERαinhibition was assessed using ELISA.The MTT assay assessed cell viability.Flow cytometry was performed for cell cycle,apoptosis,and p-Akt analyses.Chemical analysis identified the compound as 3-(4-isopropyl)benzylidene-8-ethoxy,6-methyl,chroman-4-one,which showed high binding efficacy toward ER,with aΔG_(binding) score of−7.4 kcal/mol.SBL-060 inhibited ERα,exhibiting IC50 values of 448 and 374.3 nM in THP-1 and HL-60 cells,respectively.Regarding inhibited cell proliferation,GI50 values of SBL-060 were 244.1 and 189.9 nM for THP-1 and HL-60 cells,respectively.In addition,a dose-dependent increase in sub G_(0)/G_(1) phase cell cycle arrest and total apoptosis was observed after treatment with SBL-060 in both cell types.SBL-060 also dose-dependently increased the p-Akt-positive populations in both THP-1 and HL-60 cells.Our results indicate that SBL-060 has excellent efficacy against differentiated AML cell types by inhibiting ER and Akt kinase,warranting further preclinical evaluations. 展开更多
关键词 Akt kinase AML THP-1 HL-60 Estrogen receptor benzylidene compounds
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Preparation and Properties of 1-octadecanol/1,3:2,4-di-(3,4-dimethyl) Benzylidene Sorbitol/Expanded Graphite Form-stable Composite Phase Change Material
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作者 XU Jun CHENG Xiaomin 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2019年第3期728-735,共8页
A 1-octadecanol(OD)/1,3:2,4-di-(3,4-dimethyl) benzylidene sorbitol(DMDBS)/expander graphite(EG) composite was prepared as a form-stable phase change material(PCM) by vacuum melting method. The results of fie... A 1-octadecanol(OD)/1,3:2,4-di-(3,4-dimethyl) benzylidene sorbitol(DMDBS)/expander graphite(EG) composite was prepared as a form-stable phase change material(PCM) by vacuum melting method. The results of field emission-scanning electron microscopy(FE-SEM) showed that 1-octadecanol was restricted in the three-dimensional network formed by DMDBS and the honeycomb network formed by EG. X-ray diffraction(XRD) and Fourier transform infrared spectroscopy(FT-IR) results showed that no chemical reaction occurred among the components of composite PCM in the preparation process. The gel-to-sol transition temperature of the composite PCMs containing DMDBS was much higher than the melting point of pure 1-octadecanol. The improvements in preventing leakage and thermal stability limits were mainly attributed to the synergistic effect of the three-dimensional network formed by DMDBS and the honeycomb network formed by EG. Differential scanning calorimeter(DSC) was used to determine the latent heat and phase change temperature of the composite PCMs. During melting and freezing process the latent heat values of the PCM with the composition of 91% OD/3% DMDBS/6% EG were 214.9 and 185.9 kJ·kg-1, respectively. Its degree of supercooling was only 0.1 ℃. Thermal constant analyzer results showed that its thermal conductivity(κ) changed up to roughly 10 times over that of OD/DMDBS matrix. 展开更多
关键词 1-octadecanol 1 3 4-di-(3 4-dimethyl) benzylidene sorbitol expander graphite composite phase change materials synergistic effect GELATOR
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A New Method for the Cleavage of Carbohydrate Benzylidene Acetal by Ceric (IV) Ammonium Nitrate in CH_3CN-H_2O (10: 1)
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作者 Shou Fu LU Qin Qin OUYANG +2 位作者 Zhong Wu GUO Biao YU and Yong Zheng HUI(State Key Laboratory of Bio-organic and Natural Products Chemistry,Shanghai Institute of Organic Chemistry, Academia Sinica, Shanghai 200032) 《Chinese Chemical Letters》 SCIE CAS CSCD 1997年第10期841-842,共2页
A new method for the cleavage of carbohydrate benzylidene acetal has been developed using Ceric (YV) ammonium nitrate (CAN) [(NH4)2Ce(NO3)6] in CH3CN-H2O (10/1, v/v).
关键词 CH A New Method for the Cleavage of Carbohydrate benzylidene Acetal by Ceric Ammonium Nitrate in CH3CN-H2O CN IV
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Synthesis,Crystal Structure and Fluorescent Properties of 1-(4-(Dimethylamino)benzylidene)-4-(naphthalen-1-yl) Thiosemicarbazide
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作者 YU Yun LIN Li-Rong HUANG Rong-Bin 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2006年第10期1197-1202,共6页
The title compound, 1-4-(dimethylamino)benzylidene)-4-(naphthalene-1-yl) thiosemicarbazide (DMABNTS, C20H20N4S, Mr = 348.47), was synthesized and characterized by elemental analysis, 1R, ^1H NMR and MS. The cry... The title compound, 1-4-(dimethylamino)benzylidene)-4-(naphthalene-1-yl) thiosemicarbazide (DMABNTS, C20H20N4S, Mr = 348.47), was synthesized and characterized by elemental analysis, 1R, ^1H NMR and MS. The crystal structure of DMABNTS with 1,4-dioxane (Diox, C4H8O2) solvent molecules (DMABNTS·2Diox, C28H36N4O4S, Mr = 524.67) was determined by single-crystal X-ray diffraction. The crystal belongs to monoclinic system, space group P21/c with a = 14.418(4), b = 7.1702(19), c = 28.350(7)°A,β= 101.154(6)°, V= 2875.4(13) °A^3, Z= 4, Dc= 1.212 g/cm^3, F(000) = 1120 and μ= 0.151 mm^-1. A total of 6458 reflections were collected, of which 4671 were unique. The structure was solved by direct methods and refined to the final R = 0.0732 and wR = 0.2127 for 3921 observed reflections (I〉 2σ(I)). There exist intermolecular hydrogen bonds (N(2)-H(2B)…S(1A)and N(1)-H(1A)…O(4B)) in the structure. The study of fluorescent properties 'shows that DMABNTS emits bright solid-state fluorescence in the visible region and exhibits blue photoluminescence. 展开更多
关键词 1-(4-(dimethylamino)benzylidene)-4-(naphthalen- 1-yl)thiosemicarbazide SYNTHESIS crystal structure fluorescence
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Synthesis and Crystal Structure of [2-Hydroxy-5-(4-hydroxy-3-phenyliminomethyl-benzyl)-benzylidene]-phenyl-amine
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作者 丁瑜 库宗军 +2 位作者 周环波 余华莉 高大顺 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2009年第6期699-702,共4页
The title compound [2-hydroxy-5-(4-hydroxy-3-phenyliminomethyl-benzyl)-benzylidene]-phenyl-amine (C27H22N2O2, Mr = 406.47) was synthesized by 5,5′-methylene-bissalicylal- dehyde with aminobenezene, and its crysta... The title compound [2-hydroxy-5-(4-hydroxy-3-phenyliminomethyl-benzyl)-benzylidene]-phenyl-amine (C27H22N2O2, Mr = 406.47) was synthesized by 5,5′-methylene-bissalicylal- dehyde with aminobenezene, and its crystal structure was determined by single-crystal X-ray diffraction. The crystal belongs to the monoclinic system, space group C2/c with a = 4.4026(6), b = 1.501(13), c = 0.95818(12) nm, β = 90.868(2)°, V= 4.2813(9) nm^3, Z= 8, Dc= 1.292 g/cm^3,μ = 0.010, F(000) = 1744, R = 0.0576 and wR = 0.1450 for 3766 observed reflections with I 〉 2σ(I). X-ray analysis reveals that the molecule has a pair of intramolecular OH…N hydrogen bonds. 展开更多
关键词 synthesis crystal structure [2-hydroxy-5-(4-hydroxy-3-phenyUminomethylbenzyl)- benzylidene]-phenyl-amine
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Bis(1-(4-(dimethylamino)benzylidene)-4-phenylthiose micarbaznato)palladium(Ⅱ):Synthesis,Crystal Structure and Its Dual Fluorescence Property
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作者 徐勤娟 林丽榕 +2 位作者 孙頔 黄荣彬 郑兰荪 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2010年第8期1169-1174,共6页
The title compound bis(1-(4-(dimethylamino)benzylidene)-4-phenylthiosemicar-bazato)-palladium(Ⅱ)(PdL2) was obtained by reacting 1-(4-(dimethylamino)benzylidene)-4-phenyl-thiosemicarbazide with dichloro... The title compound bis(1-(4-(dimethylamino)benzylidene)-4-phenylthiosemicar-bazato)-palladium(Ⅱ)(PdL2) was obtained by reacting 1-(4-(dimethylamino)benzylidene)-4-phenyl-thiosemicarbazide with dichlorobis(benzonitrile)palladium(Ⅱ) in methanol,and its structure was characterized by single-crystal X-ray diffraction.The crystal of PdL2 was obtained in dimethyl-formamide(DMF) solvent with solvent molecules involved in the cell and crystallizes in the monoclinic system,space group C2 with a = 18.485(15),b = 7.090(5),c = 17.595(11) ,β = 121.21(3)o,V = 1972(2) 3,Z = 2,Mr = 847.40,Dc = 1.427 g/cm3,μ = 0.624 mm-1,F(000) = 880,R = 0.0607 and wR = 0.1358.The Pd atom adopts a distorted square planar coordination geometry with two Pd-N and two Pd-S bonds.The ligand loses a proton from its tautomeric thiol form and coordinates to the Pd atom via mercapto sulfur and the imine nitrogen atom,which binds to palladium as bidentate N,S-donors forming five-membered chelate rings.The complex formed hydrogen bonding interaction with solvent DMF molecules from the hydrogen of phenylamine to the oxygen of DMF and several intramolecular hydrogen bonds.Pd(Ⅱ) perturbed ligand π-π* transition and metal-to-ligand charge transfer(MLCT) transition are observed in its electronic absorption spectra.The complex exhibits intraligand 1π-π*(IL) state and MLCT state dual fluorescent emissions in organic solvent at room temperature. 展开更多
关键词 palladium(Ⅱ) complex 1-(4-(dimethylamino)benzylidene)-4-phenylthiosemicarbazide dual fluorescence crystal structure
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Formation of α,α'-Bis(substituted benzylidene)cycloalkanones from Masked Aldehydes Promoted by Samarium(III) Triiodide
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作者 XiaoXiaWANG YongMinZHANG 《Chinese Chemical Letters》 SCIE CAS CSCD 2004年第5期511-514,共4页
Diacetates 1 and N-[(1-benzotriazol-l-yl)alkyl]amides 2, both masked forms of aldehydes, could undergo deprotection and condensation with cycloalkanones in a one-pot procedure promoted by samarium(III) iodide (SmI3) ... Diacetates 1 and N-[(1-benzotriazol-l-yl)alkyl]amides 2, both masked forms of aldehydes, could undergo deprotection and condensation with cycloalkanones in a one-pot procedure promoted by samarium(III) iodide (SmI3) to afford α,α'-bis(substituted benzylidene) cycloalkanones in good yields. 展开更多
关键词 Samarium(III) triiodide α α'-bis(substituted benzylidene)cycloalkanone 1 1-diacetate N-[(l-benzotriazol-1-yl)alkyl]amide. Quinolone antibacterial agents have emerged as one of the dominant classes
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Sodium-Modified Fluorapatite: A Mild and Efficient Reusable Catalyst for the Synthesis of <i>α,α</i>’-Bis(Substituted Benzylidene) Cycloalkanones under Conventional Heating and Microwave Irradiation
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作者 Bahija Mounir Fathallaah Bazi +2 位作者 Abddelfetah Mounir Mohamed Zahouily Hamid Toufik 《Green and Sustainable Chemistry》 2018年第2期156-166,共11页
A versatile and environmentally friendly method for α,α’-bis(substituted ben-zylidene) cycloalkanones has been developed using a heterogeneous catalysis technology. We have synthesized a series of the α,α’-bis(s... A versatile and environmentally friendly method for α,α’-bis(substituted ben-zylidene) cycloalkanones has been developed using a heterogeneous catalysis technology. We have synthesized a series of the α,α’-bis(substituted benzylidene) cycloalkanones, a biologically important class of compounds, via the cross aldol condensation between arylaldehydes and cycloketones using sodium-modified fluorapatite (Na/FAP) as a highly efficient solid catalyst under conventional heating in aqueous media and solventless conditions under microwave. Catalyst reuse, ease of separation of the pure product, and high yields are some of the unique features of this process. Shorter reaction times (4 - 7 min) and higher yields (80% - 94%) were achieved under microwave irradiation conditions. 展开更多
关键词 Green Chemistry α α’-Bis(Substituted benzylidene) CYCLOALKANONES Microwaves Irradiation Conventional Heating Aqueous Media FLUORAPATITE Activated by SODIUM Nitrate (Na/FAP)
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Synthesis,antimicrobial evaluation and QSAR studies of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides 被引量:1
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作者 Davinder Kumar Archana Kapoor +2 位作者 Ananda Thangadurai Pradeep Kumar Balasubramanian Narasimhan 《Chinese Chemical Letters》 SCIE CAS CSCD 2011年第11期1293-1296,共4页
A series of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides(1-20) was synthesized and tested for in vitro antimicrobial activity.The results of antimicrobial studies indicated that the compounds having d... A series of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides(1-20) was synthesized and tested for in vitro antimicrobial activity.The results of antimicrobial studies indicated that the compounds having dinitro,methoxy,hydroxy and nitro substituents on phenyl ring of the aromatic acids were most active ones.The QSAR investigation indicated the importance of the topological parameter,third order molecular connectivity index(~3x) in describing the antimicrobial activity of synthesized hydrazides. 展开更多
关键词 benzylidene hydrazides SYNTHESIS ANTIMICROBIAL mt-QSAR LOO method
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Visible-light-induced novel cyclization of 2-(2-(arylethynyl)benzylidene)-malononitrile derivatives with 2,6-di(tert-butyl)-4-methylphenol to bridged spirocyclic compounds
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作者 Xiaofei Xie Lei Wang +3 位作者 Quan Zhou Yongmin Ma Zhi-Ming Wang Pinhua Li 《Chinese Chemical Letters》 SCIE CAS CSCD 2022年第12期5069-5073,共5页
A green and highly efficient strategy for the preparation of bridged spirocyclic compounds via visible-light-induced cyclization of 2-(2-(arylethynyl)benzylidene)malononitrile derivatives with 2,6-di(tert-butyl)-4-met... A green and highly efficient strategy for the preparation of bridged spirocyclic compounds via visible-light-induced cyclization of 2-(2-(arylethynyl)benzylidene)malononitrile derivatives with 2,6-di(tert-butyl)-4-methylphenol(BHT)at room temperature was developed.The photoinduced radical reactions generated the corresponding products in good yields under simple and mild reaction conditions. 展开更多
关键词 2-(2-(Arylethynyl)benzylidene)malononitriles 2 6-Di(tert-butyl)-4-methylphenol Bridged spirocyclic compounds Visible-light-induced organosynthesis
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Potential anti-tubercular agents:Hexahydro-3-phenyl indazol-2-yl(pyridin-4-yl)methanones from anti-tubercular drug isoniazid and bis(substituted-benzylidene)cycloalkanones
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作者 Ayyakannu Arumugam Napoleon Fazlur-Rahman Nawaz Khan +1 位作者 Euh Duck Jeong Eun Hyuk Chung 《Chinese Chemical Letters》 SCIE CAS CSCD 2015年第5期567-571,共5页
A series of indazol-2-yl(pyridin-4-yl)methanones, 4 were acquired from 2,6-bisbenzylidene cyclohex- anones, 3 and anti-tubercular drug (isoniazid), and their anti-tubercular impacts were screened. Among the test c... A series of indazol-2-yl(pyridin-4-yl)methanones, 4 were acquired from 2,6-bisbenzylidene cyclohex- anones, 3 and anti-tubercular drug (isoniazid), and their anti-tubercular impacts were screened. Among the test compounds used against Mycobacterium tuberculosis H37 Ra cell line in the microplate alamar blue assay, the compounds 4g-j revealed moderate anti-tubercular activity with MIC 12.5 μg/mL, comparable to standard drugs (streptomycin, MIC, 6.25 μg/mL, pyrazinamide, isoniazid and ciprofloxacin with MICs of 3.125 μg/mL). 展开更多
关键词 benzylidene cyclohexanones Hexahydro-3-phenyl indazol-2-yl (pyridin- 4-yl)methanones lsoniazid Anti-tubercular activity
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An unexpected synthesis of an α,β,γ,δ-unsaturated ketone due to an abnormal opening of benzylidene acetal by bromide anion
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作者 魏常青 赵刚 丁渝 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2000年第2期212-219,共0页
An unexpected synthesis of an α, β, γ, δ-unsaturated ketone, which embodies a new type of oxy-carbon cyclic structure, was achieved, while we tried to construct the taxane CB-ring system. Also, a series of abnorma... An unexpected synthesis of an α, β, γ, δ-unsaturated ketone, which embodies a new type of oxy-carbon cyclic structure, was achieved, while we tried to construct the taxane CB-ring system. Also, a series of abnormal reaction phenomens was found to be related to the formation and reaction of seven membered cyclic benzylidene acetal. 展开更多
关键词 synthesis unsaturated ketone seven membered cyclic benzylidene acetal
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Design and Synthesis of New Compounds Derived from Phenyl Hydrazine and Different Aldehydes as Anticancer Agents 被引量:1
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作者 Mo’men Salem Rezk Ayyad +1 位作者 Helmy Sakr Ahmed Gaafer 《International Journal of Organic Chemistry》 CAS 2022年第1期28-39,共12页
In this work we synthesized new derivatives from Phenyl Hydrazine and series of different Aldehydes (derivatives of benzylidenes). The synthesized compounds contain different aromatic Aldehydes which attached by Benze... In this work we synthesized new derivatives from Phenyl Hydrazine and series of different Aldehydes (derivatives of benzylidenes). The synthesized compounds contain different aromatic Aldehydes which attached by Benzene ring via Hydrazine moiety in glacial acetic acid. These derivatives were characterized by TLC, melting points, Infrared Red, Proton Nuclear Magnetic Resonance, Carbon Thirteen Nuclear Magnetic Resonance and Mass Spectroscopy. Finally, these synthesized derivatives were tested for antiproliferative activity against multiple normal and cancerous cell lines, HepG2 (Liver cancer) and MCF-7 (Breast cancer) cell lines were used for cytotoxic assay. 展开更多
关键词 Phenyl Hydrazine Aromatic Aldehydes benzylidene Synthesis Cytotoxic Assay Anticancer HepG2 and MCF-7
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Design and Synthesis of Some New Oxadiazole Derivatives as Anticancer Agents
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作者 Mo’men Salem Rezk Ayyad Helmy Sakr 《International Journal of Organic Chemistry》 CAS 2022年第2期64-74,共11页
In this work, some new oxadiazole derivatives have been prepared, by reacting phenyl hydrazine and acetic anhydride together, which furnished 2,4-dimethyl-4-phenyloxadiazole. This product was reacted with a series of ... In this work, some new oxadiazole derivatives have been prepared, by reacting phenyl hydrazine and acetic anhydride together, which furnished 2,4-dimethyl-4-phenyloxadiazole. This product was reacted with a series of aromatic aldehydes, to obtain a series of oxadiazole derivatives. These derivatives were characterized by TLC, melting points, infrared red, proton nuclear magnetic resonance, carbon thirteen nuclear magnetic resonance and mass spectroscopy. Finally, these synthetized derivatives were tested for antiproliferative activity by two different cell lines. MCF-7 (Breast cancer cell line) and HepG2 (Liver cancer cell line) were used to assess the antiproliferative activity of the prepared compounds. 展开更多
关键词 Phenyl Hydrazine OXADIAZOLE Aromatic Aldehydes Acetic Anhydride benzylidene Synthesis Cytotoxic Assay ANTICANCER HepG2 and MCF-7
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Synthesis of Substituted Benzothiazepine Compounds with Medicinal Potential
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作者 Clare E. Gutteridge Brett W. Sadowski +6 位作者 Stephen M. Hughes J. Alan Friedlander Leighton G. Rodrigo Michael C. Baxter Nathan C. Lorei Jonathan E. Harrell Michael T. O’Neil 《International Journal of Organic Chemistry》 2020年第3期123-134,共12页
A versatile synthetic approach toward a series of benzothiazepines with medicinal potential (for example, compound <strong>1</strong>) that allows incorporation of structural variation at the three aromati... A versatile synthetic approach toward a series of benzothiazepines with medicinal potential (for example, compound <strong>1</strong>) that allows incorporation of structural variation at the three aromatic regions of the structure, and at the sulfur atom, was developed. Knoevenagel condensation of indan-1,3-diones with benzaldehydes, yielded 2-benzylidineindan-1,3-diones, which undewent thio-Michael addition and intramolecular imine formation upon reaction with 2-aminothiophenols, to produce the target benzothiazepines. Use of indan-1,3-diones, benzaldehydes or 2-aminothiophenols bearing further substitution enabled production of novel 5,11-dihydro-12H-benzo[b]indeno [1,2-e][1,4]thiazepin-12-one analogs <strong>1</strong> - <strong>14</strong>, including compounds bearing substitution at novel positions within the scaffold. 展开更多
关键词 BENZOTHIAZEPINE Knoevenagel Condensation Thio-Michael Addition benzylidene Indandione 2-Aminothiophenol
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A Novel Tetraphenylethylene-Based“Turn On”Fluorescent Sensor with Highly Sensitive Response to Mercury Ions
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作者 GUI Meifang PENG Yanfeng +2 位作者 ZHANG Min LIU Tianbao WANG Xin 《Wuhan University Journal of Natural Sciences》 CAS CSCD 2020年第5期417-422,共6页
A novel 4-tert-butyl-N’-(4-(1,2,2-triphenylvinyl)benzylidene)benzohydrazide(TBB)was successfully synthesized in simple one-step process.It was characterized by FT-IR,1H NMR,13C NMR and HRMS.Its fluorescence sensing a... A novel 4-tert-butyl-N’-(4-(1,2,2-triphenylvinyl)benzylidene)benzohydrazide(TBB)was successfully synthesized in simple one-step process.It was characterized by FT-IR,1H NMR,13C NMR and HRMS.Its fluorescence sensing ability to 15 metal ions was investigated.Weak emission from TBB could be efficiently increased by trace Hg^2+,through coordination reaction between TBB and Hg^2+ with"turn on"character.The fluorescence intensity of TBB/Hg^2+([TBB]=3.0×10^–6 mol/L,[Hg2+]=1.3×10^–4 mol/L)was 7.5 times higher than that of TBB.This TBB sensor exhibited high selectivity for Hg^2+ and other metal ions did not interfere in this determination.The limit of detection was 0.566μmol/L(S/N=3).The experimental results showed that this TBB sensor could sensitively respond to Hg^2+ within concentration range(from 5×10–6 mol/L to 1.3×10^–4 mol/L). 展开更多
关键词 4-tert-butyl-N’-(4-(1 2 2-triphenylvinyl)benzylidene)benzohydrazide(TBB) turn on Hg2+ coordination reaction
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Synthesis of propyl O-(α-L-rhamnopyranosyl)-(1→3)-[2,4-di-O-(2s-methylbutyryl)-α-L-rhamno-pyranosyl]-(1→2)-(3-O-acetyl-β-D-glucopyranosyl)-(1→2)-β-D-fucopyranoside,the tetrasaccharide moiety of Tricolorin A
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作者 卢寿福 欧阳琴琴 +2 位作者 郭忠武 俞飚 惠永正 《Chinese Journal of Chemistry》 SCIE CAS CSCD 1998年第1期78-89,共12页
Propyl O-(α-L-rhamncpyranosyl)-(1→3)-[2,4-di-O-(2s-methylbutyryl)-α-L-rham-nopyranosyl]-(1→2)-(3-O-acetyl-β-D-glucopyranosyl)-(1→2)-β-D-fucopyranoside (1), the tetrasac-charide moiety of Tricolorin A, was synth... Propyl O-(α-L-rhamncpyranosyl)-(1→3)-[2,4-di-O-(2s-methylbutyryl)-α-L-rham-nopyranosyl]-(1→2)-(3-O-acetyl-β-D-glucopyranosyl)-(1→2)-β-D-fucopyranoside (1), the tetrasac-charide moiety of Tricolorin A, was synthesized in total 23 steps with a longest linear sequence of 10 steps, and overall yield of 3.7% from D-Glucose. The isomerization of the dioxolane-type berzyli-dene in the presence of NIS/AgOTf was observed. Tetrasaccharide 1 exhibited no activity against the cultured P388 cell as Tricolorin A did. 展开更多
关键词 Propyl O-(α-L-rhamnopyranosyl)-(1→3)-[2 4-di-O-(2s-methylbutyryl)-α-L-rham-nopyranosyl]-(1→2)-(3-O-acetyl-β-D-glucopyranosyl)-(1→2)-β-D-fucopyranoside synthesis dioxo-lane-type benzylidene Tricolorin A
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