Several studies on earthquake occurrence and associated faulting have demonstrated that both phenomena have a scale-invariant behavior which can be analyzed by means of a set of non-integer dimensions （Dq） describin...Several studies on earthquake occurrence and associated faulting have demonstrated that both phenomena have a scale-invariant behavior which can be analyzed by means of a set of non-integer dimensions （Dq） describing their fractal properties and the calculation ofmulti-fractal spectra. It is the case that the behavior of these spectra is asymptotic at the ends of the variation interval of q, which is a real number that enters into the definition of the partition function of the dataset. The difference between the extreme values, called multi-fractal spectrum slope, is used to investigate the heterogeneity of the spatial distribution of earthquakes and fault systems. In this paper we focus on the Betic Cordillera, southeastern Spain, which is commonly considered the contact between the Eurasian and African plates and has an important seismic activity in the context of the Iberian Peninsula. Some of the most conspicuous Iberian earthquakes, such as the 1829 mb6.3 Torrevieja and the 1884 mb6.1 Alhama de Granada earthquakes occurred in this mountain range and both reached intensity X. The pre- sent work implies a new analysis based on the slope of multi-fractal spectra and referred to the historical seismicity of the re- gion, specifically b-value （frequency distribution of earthquakes respect to magnitude）, epicentral location, seismic energy and faulting. On this basis we propose a seismotectonic zonation that is contrasted with the stress state and the geodynamical evolution of the Betic Cordillera.展开更多
Redox balance is fundamentally important for physiological homeostasis. Pathological factors that disturb this dedicated balance may result in oxidative stress, leading to the development or aggravation of a variety o...Redox balance is fundamentally important for physiological homeostasis. Pathological factors that disturb this dedicated balance may result in oxidative stress, leading to the development or aggravation of a variety of diseases, including diabetes mellitus, cardiovascular diseases, metabolic syndrome as well as inflammation, aging and cancer. Thus, the capacity of endogenous free radical clearance can be of patho-physiological importance; in this regard, the major reactive oxygen species defense machinery, the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) system needs to be precisely modulated in response to pathological alterations. While oxidative stress is among the early events that lead to the development of insulin resistance, the activation of Nrf2 scavenging capacity leads to insulin sensitization. Furthermore, Nrf2 is evidently involved in regulating lipid metabolism. Here we summarize recent findings that link the Nrf2 system to metabolic homeostasis and insulin action and present our view that Nrf2 may serve as a novel drug target for diabetes and its complications.展开更多
Objective:To compare the physiologically active substances,antioxidant and anti diabetic activities in vitro of bitter melon fruit and leaf extract.Methods:Total polyphenol and flavonoid contents were measured using s...Objective:To compare the physiologically active substances,antioxidant and anti diabetic activities in vitro of bitter melon fruit and leaf extract.Methods:Total polyphenol and flavonoid contents were measured using spectrophotometrically by gallic acid and catechin standard curves,respectively.The radical-scavenging potential of bitter melon fruit and leaf extract were measured by DPPH,ABTS and hydroxyl radical scavenging ability and reducing power and anti-diabetic ability was evaluated byα-glucosidase activity.Results:It was confirmed that the bitter melon leaf contained more total polyphenols and flavonoidsthan bitter melon fruits.Bitter melon leaf extract contained 2.8-fold and 4.9-fold higher total polyphenols and flavonoids than bitter melon fruits,respectively.The DPPH radical scavenging activity of bitter melon leaf was 5.81-and 5.70-fold higherthan that of the bitter melon frui,based on200μg/mL and 400μg/mL of the extract,respectively.In ABTS,hydroxyl radical scavenging ability and reducing power,the bitter melon leaf extract all showed higher antioxidant capacity than the bitter melon fruit.Bitter melon fruit showed 2.52-and 2.63-fold higherα-glucosidase inhibitory activity than bitter melon leaf extract at 200μg/mL and 400μg/mL,respectively.Conclusions:Based on our results,bitter melon may improve antidiabetic effects by upreguatingα-glycosidase activity.Even,bitter melon leaf extract shows higher antioxidant potential than its fruit but bitter melon leaf extract does not show higherα-glucosidase inhibitory potential than bitter melon fruit.The overall results support that bitter melon fruit and leaf may have specific torget effects on antidiabetic and antioxidant,respectively.展开更多
基金The Ministry of Education and Science funded this study (project CGL2007-60535)sponsored by the Junta de Andalucía, Spain, through the Research Groups RNM-217 and RNM-024
文摘Several studies on earthquake occurrence and associated faulting have demonstrated that both phenomena have a scale-invariant behavior which can be analyzed by means of a set of non-integer dimensions （Dq） describing their fractal properties and the calculation ofmulti-fractal spectra. It is the case that the behavior of these spectra is asymptotic at the ends of the variation interval of q, which is a real number that enters into the definition of the partition function of the dataset. The difference between the extreme values, called multi-fractal spectrum slope, is used to investigate the heterogeneity of the spatial distribution of earthquakes and fault systems. In this paper we focus on the Betic Cordillera, southeastern Spain, which is commonly considered the contact between the Eurasian and African plates and has an important seismic activity in the context of the Iberian Peninsula. Some of the most conspicuous Iberian earthquakes, such as the 1829 mb6.3 Torrevieja and the 1884 mb6.1 Alhama de Granada earthquakes occurred in this mountain range and both reached intensity X. The pre- sent work implies a new analysis based on the slope of multi-fractal spectra and referred to the historical seismicity of the re- gion, specifically b-value （frequency distribution of earthquakes respect to magnitude）, epicentral location, seismic energy and faulting. On this basis we propose a seismotectonic zonation that is contrasted with the stress state and the geodynamical evolution of the Betic Cordillera.
基金Supported by An operating grant from Canadian Institutes of Health Research,No.89887 to Jin TRa NSFC grant,No.81072300 to Jin TR and Yu ZWa NSFC grant,No.30730079 to Ling WH in part
文摘Redox balance is fundamentally important for physiological homeostasis. Pathological factors that disturb this dedicated balance may result in oxidative stress, leading to the development or aggravation of a variety of diseases, including diabetes mellitus, cardiovascular diseases, metabolic syndrome as well as inflammation, aging and cancer. Thus, the capacity of endogenous free radical clearance can be of patho-physiological importance; in this regard, the major reactive oxygen species defense machinery, the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) system needs to be precisely modulated in response to pathological alterations. While oxidative stress is among the early events that lead to the development of insulin resistance, the activation of Nrf2 scavenging capacity leads to insulin sensitization. Furthermore, Nrf2 is evidently involved in regulating lipid metabolism. Here we summarize recent findings that link the Nrf2 system to metabolic homeostasis and insulin action and present our view that Nrf2 may serve as a novel drug target for diabetes and its complications.
基金funded by the Basic Science Research Program supported by the National Research Foundation of Korea(NRF-2016R1A2B4014977)
文摘Objective:To compare the physiologically active substances,antioxidant and anti diabetic activities in vitro of bitter melon fruit and leaf extract.Methods:Total polyphenol and flavonoid contents were measured using spectrophotometrically by gallic acid and catechin standard curves,respectively.The radical-scavenging potential of bitter melon fruit and leaf extract were measured by DPPH,ABTS and hydroxyl radical scavenging ability and reducing power and anti-diabetic ability was evaluated byα-glucosidase activity.Results:It was confirmed that the bitter melon leaf contained more total polyphenols and flavonoidsthan bitter melon fruits.Bitter melon leaf extract contained 2.8-fold and 4.9-fold higher total polyphenols and flavonoids than bitter melon fruits,respectively.The DPPH radical scavenging activity of bitter melon leaf was 5.81-and 5.70-fold higherthan that of the bitter melon frui,based on200μg/mL and 400μg/mL of the extract,respectively.In ABTS,hydroxyl radical scavenging ability and reducing power,the bitter melon leaf extract all showed higher antioxidant capacity than the bitter melon fruit.Bitter melon fruit showed 2.52-and 2.63-fold higherα-glucosidase inhibitory activity than bitter melon leaf extract at 200μg/mL and 400μg/mL,respectively.Conclusions:Based on our results,bitter melon may improve antidiabetic effects by upreguatingα-glycosidase activity.Even,bitter melon leaf extract shows higher antioxidant potential than its fruit but bitter melon leaf extract does not show higherα-glucosidase inhibitory potential than bitter melon fruit.The overall results support that bitter melon fruit and leaf may have specific torget effects on antidiabetic and antioxidant,respectively.
