AIM:To study of corneal biomechanical properties and intraocular pressure(IOP)measured with Corvis Scheimpflug Technology(ST)in patients with childhood glaucoma(CG).METHODS:Cross-sectional study in which 89 eyes were ...AIM:To study of corneal biomechanical properties and intraocular pressure(IOP)measured with Corvis Scheimpflug Technology(ST)in patients with childhood glaucoma(CG).METHODS:Cross-sectional study in which 89 eyes were included 56 of them with CG.Only one eye per patient was included.The following variables were obtained from the clinical history and the ophthalmological examination:age,sex,IOP,number of surgeries,and the cup/disc ratio(CDR).The following parameters were recorded using Corvis ST:corrected by biomechanics IOP(b IOP),not corrected IOP(nct IOP),central corneal thickness(CCT),maximum concavity[radius,peak distance(PD)and deformation amplitude],applanation 1 and 2(length and velocity).The mean age was 23±14.55 and 33±19.5 years old for the control group and CG group,respectively.Totally 36 were males and 53 were females.In the CG group,7 patients were controlled only with medical treatment.Sixteen had at least one previous goniotomy,19 had at least one trabeculectomy,and 11 had an Ahmed implant.RESULTS:A significant and positive intraclass correlation coefficient was found between Goldman IOP and the IOP measured by Corvis in both groups.No differences were found between the IOP measured with Corvis and Goldman using a student t-test.Regarding biomechanical parameters,there were differences in the applanation length 2(A-L2),in the applanation velocity 2(A-V2)and in the PD.By sex,only the applanation length 1(A-L1)was found to be different in control group.A positive and significant Pearson correlation was found between CDR and the A-L1.CONCLUSION:Corneal biomechanical properties have shown differences between CG and healthy subjects and also between men and women.展开更多
Microtubules (MT) are of great engineering importance due to their potential applications as sensors, actuators, drug delivery, and others. The MT properties/mechanics are greatly affected by their biomechanical envir...Microtubules (MT) are of great engineering importance due to their potential applications as sensors, actuators, drug delivery, and others. The MT properties/mechanics are greatly affected by their biomechanical environment and it is important to understand their biological function. Although microtubule mechanics has been extensively studied statically, very limited studies are devoted to the biomechanical properties of microtubule undergoing deformation and vibration. In this study, we investigate the biomechanical properties of the microtubule under bending deformation and free vibration using 3D finite element analysis. Results of force-deformation and vibration frequencies and mode shapes obtained from the finite element analysis are presented. The results indicate that the force-deformation characteristics vary with time/phases and become non-linear at higher time intervals. The modes of MT vibration and frequencies are in the GHz range and higher modes will involve combined bending, torsion and axial deformations. These higher modes and shapes change their deformation which might have implications for physiological and biological behavior, especially for sensing and actuation and communication to cells. The bending force-deformation characteristics and vibration modes and frequencies should help further understand the biomechanical properties of self-assembled microtubules.展开更多
Entangled Porous Titanium Alloy Metal Rubber(EPTA-MR)was used as a nucleus pulposus material in the design of non-fusion intervertebral disc prosthesis for the first time.A novel artificial lumbar intervertebral disc ...Entangled Porous Titanium Alloy Metal Rubber(EPTA-MR)was used as a nucleus pulposus material in the design of non-fusion intervertebral disc prosthesis for the first time.A novel artificial lumbar intervertebral disc prosthesis was designed by reconstructing the lumbar model with reverse engineering technology,and the biomechanical behavior of the prosthesis was simulated under varied working conditions.The nucleus pulposus size was determined by the actual size of human prosthesis.EPTA-MR samples with different densities were prepared by medical titanium alloy wire experimental studies were conducted on static stiffness,damping energy consumption,and fatigue life.The results indicated that the static stiffness of EPTA-MR could reach approximately 1500 N mm and its loss factor remained higher than 0.2,and the variation range was relatively small,with excellent vibration damping capacity and bearing capacity.Among them,the overall performance of EPTA-MR with a density of 2.5 g em 3 was closer to that of the physiologic intervertebral disc.A macro experiment of five million fatigue vibration tests combined with microstructure observation exhibited a wear rate of only 0.9396 g-MC with no noticeable change in the internal micro-morphology.Therefore,the EPTA-MR has a broad application prospect as the nucleus pulposus material of artificial intervertebral disc prosthesis.展开更多
Background:Robot-assisted gait training(RAGT)is more effective in the range of motion(ROM)and isometric strength in patients with burns than conventional training.However,concerns have been raised about whether RAGT m...Background:Robot-assisted gait training(RAGT)is more effective in the range of motion(ROM)and isometric strength in patients with burns than conventional training.However,concerns have been raised about whether RAGT might negatively affect the scars of patients with burns.Therefore,we investigated the effects of RAGT-induced mechanical load on the biomechanical properties of burn scars.Methods:This was a single-blind,randomized clinical trial conducted on inpatients admitted to the Department of Rehabilitation Medicine between September 2020 and August 2021.RAGT was conducted for 30 min per day,five days a week for 12 weeks and the control group received conventional gait training for 12 weeks.The pre-training ROM of lower extremity joints was evaluated and the levels of melanin,erythema,trans-epidermal water loss,scar distensibility and elasticity were assessed before training and at 4 and 12 weeks after training.Finally,19 patients in the gait assistance robot(GAR)group and 20 patients in the control group completed the 12-week trial and all evaluations.Results:There were no significant differences in the epidemiologic characteristics,pre-training ROM of joints and pre-training biomechanical properties of the burn scar between the groups(p>0.05 for all).None of the patients experienced skin abrasion around the burn scar where the fastening belts were applied or musculoskeletal or cardiovascular adverse events during the training.Scar thickness significantly increased in both groups(p=0.037 and p=0.019)and scar distensibility significantly decreased in the control group(p=0.011)during the training.Hysteresis was significantly decreased in the GAR group during the training(p=0.038).The GAR and control groups showed significant difference in the change in the values of hysteresis between pre-training and 12 weeks after training(p=0.441 and p=0.049).Conclusions:RAGT significantly decreased hysteresis in hypertrophic burn scars and did not cause a significant decrease in skin distensibility.Moreover,no skin complications around the burn scars were detected during RAGT.展开更多
This paper studied experimentally and theoretically the biomechanical properties of skin with laser influence. Different types of tensile tests of the porcine skin in vitro were conducted to study effect of the laser,...This paper studied experimentally and theoretically the biomechanical properties of skin with laser influence. Different types of tensile tests of the porcine skin in vitro were conducted to study effect of the laser, tensile strength, stress-strain relationship, influence of skin's anisotropy and different regions, repetitive loading and stress-relaxation. A modeling of skin was developed according to the experimental results. The modeling provided insights into the important structure-function relationship in skin tissue with the laser effect. The nonlinear and anisotropic mechanical responses of skin are largely due to varying degree of fiber undulation which is effected by laser and outside forces. By introducing the laser factor into the constitutive modeling, the skin's biomechanical properties and the mechanism of the skin repair with laser were discussed.展开更多
文摘AIM:To study of corneal biomechanical properties and intraocular pressure(IOP)measured with Corvis Scheimpflug Technology(ST)in patients with childhood glaucoma(CG).METHODS:Cross-sectional study in which 89 eyes were included 56 of them with CG.Only one eye per patient was included.The following variables were obtained from the clinical history and the ophthalmological examination:age,sex,IOP,number of surgeries,and the cup/disc ratio(CDR).The following parameters were recorded using Corvis ST:corrected by biomechanics IOP(b IOP),not corrected IOP(nct IOP),central corneal thickness(CCT),maximum concavity[radius,peak distance(PD)and deformation amplitude],applanation 1 and 2(length and velocity).The mean age was 23±14.55 and 33±19.5 years old for the control group and CG group,respectively.Totally 36 were males and 53 were females.In the CG group,7 patients were controlled only with medical treatment.Sixteen had at least one previous goniotomy,19 had at least one trabeculectomy,and 11 had an Ahmed implant.RESULTS:A significant and positive intraclass correlation coefficient was found between Goldman IOP and the IOP measured by Corvis in both groups.No differences were found between the IOP measured with Corvis and Goldman using a student t-test.Regarding biomechanical parameters,there were differences in the applanation length 2(A-L2),in the applanation velocity 2(A-V2)and in the PD.By sex,only the applanation length 1(A-L1)was found to be different in control group.A positive and significant Pearson correlation was found between CDR and the A-L1.CONCLUSION:Corneal biomechanical properties have shown differences between CG and healthy subjects and also between men and women.
文摘Microtubules (MT) are of great engineering importance due to their potential applications as sensors, actuators, drug delivery, and others. The MT properties/mechanics are greatly affected by their biomechanical environment and it is important to understand their biological function. Although microtubule mechanics has been extensively studied statically, very limited studies are devoted to the biomechanical properties of microtubule undergoing deformation and vibration. In this study, we investigate the biomechanical properties of the microtubule under bending deformation and free vibration using 3D finite element analysis. Results of force-deformation and vibration frequencies and mode shapes obtained from the finite element analysis are presented. The results indicate that the force-deformation characteristics vary with time/phases and become non-linear at higher time intervals. The modes of MT vibration and frequencies are in the GHz range and higher modes will involve combined bending, torsion and axial deformations. These higher modes and shapes change their deformation which might have implications for physiological and biological behavior, especially for sensing and actuation and communication to cells. The bending force-deformation characteristics and vibration modes and frequencies should help further understand the biomechanical properties of self-assembled microtubules.
基金The authors thank the National Natural Science Foundation of China(Grant Nos.51805086 and 51975123)the Fujian Provincial Natural Science Foundation(Grant No.2019J01210)Fujian Province health education joint project(Grant No.2019-WJ-01).
文摘Entangled Porous Titanium Alloy Metal Rubber(EPTA-MR)was used as a nucleus pulposus material in the design of non-fusion intervertebral disc prosthesis for the first time.A novel artificial lumbar intervertebral disc prosthesis was designed by reconstructing the lumbar model with reverse engineering technology,and the biomechanical behavior of the prosthesis was simulated under varied working conditions.The nucleus pulposus size was determined by the actual size of human prosthesis.EPTA-MR samples with different densities were prepared by medical titanium alloy wire experimental studies were conducted on static stiffness,damping energy consumption,and fatigue life.The results indicated that the static stiffness of EPTA-MR could reach approximately 1500 N mm and its loss factor remained higher than 0.2,and the variation range was relatively small,with excellent vibration damping capacity and bearing capacity.Among them,the overall performance of EPTA-MR with a density of 2.5 g em 3 was closer to that of the physiologic intervertebral disc.A macro experiment of five million fatigue vibration tests combined with microstructure observation exhibited a wear rate of only 0.9396 g-MC with no noticeable change in the internal micro-morphology.Therefore,the EPTA-MR has a broad application prospect as the nucleus pulposus material of artificial intervertebral disc prosthesis.
基金supported by Market Creation Robot Supply Project 2018 through the Ministry of Trade,Industry and Energy of the Republic of Korea and Korea institute for robot industry advancement(Medical and Rehabilitation Robot Pilot Program 2018)Hallym University Research Fund 2018(HURF-2018-065)supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(2020R1l1A3074150).
文摘Background:Robot-assisted gait training(RAGT)is more effective in the range of motion(ROM)and isometric strength in patients with burns than conventional training.However,concerns have been raised about whether RAGT might negatively affect the scars of patients with burns.Therefore,we investigated the effects of RAGT-induced mechanical load on the biomechanical properties of burn scars.Methods:This was a single-blind,randomized clinical trial conducted on inpatients admitted to the Department of Rehabilitation Medicine between September 2020 and August 2021.RAGT was conducted for 30 min per day,five days a week for 12 weeks and the control group received conventional gait training for 12 weeks.The pre-training ROM of lower extremity joints was evaluated and the levels of melanin,erythema,trans-epidermal water loss,scar distensibility and elasticity were assessed before training and at 4 and 12 weeks after training.Finally,19 patients in the gait assistance robot(GAR)group and 20 patients in the control group completed the 12-week trial and all evaluations.Results:There were no significant differences in the epidemiologic characteristics,pre-training ROM of joints and pre-training biomechanical properties of the burn scar between the groups(p>0.05 for all).None of the patients experienced skin abrasion around the burn scar where the fastening belts were applied or musculoskeletal or cardiovascular adverse events during the training.Scar thickness significantly increased in both groups(p=0.037 and p=0.019)and scar distensibility significantly decreased in the control group(p=0.011)during the training.Hysteresis was significantly decreased in the GAR group during the training(p=0.038).The GAR and control groups showed significant difference in the change in the values of hysteresis between pre-training and 12 weeks after training(p=0.441 and p=0.049).Conclusions:RAGT significantly decreased hysteresis in hypertrophic burn scars and did not cause a significant decrease in skin distensibility.Moreover,no skin complications around the burn scars were detected during RAGT.
基金the National Natural Science Foundation of China (No. 51178265)
文摘This paper studied experimentally and theoretically the biomechanical properties of skin with laser influence. Different types of tensile tests of the porcine skin in vitro were conducted to study effect of the laser, tensile strength, stress-strain relationship, influence of skin's anisotropy and different regions, repetitive loading and stress-relaxation. A modeling of skin was developed according to the experimental results. The modeling provided insights into the important structure-function relationship in skin tissue with the laser effect. The nonlinear and anisotropic mechanical responses of skin are largely due to varying degree of fiber undulation which is effected by laser and outside forces. By introducing the laser factor into the constitutive modeling, the skin's biomechanical properties and the mechanism of the skin repair with laser were discussed.
