Multichromophoric boron dipyrromethene （BODIPY） dyes have been efficiently synthesized from a one-pot condensation of acyl chloride with 2,4-dimethylpyrrole and have been converted to energy transfer cassettes throu...Multichromophoric boron dipyrromethene （BODIPY） dyes have been efficiently synthesized from a one-pot condensation of acyl chloride with 2,4-dimethylpyrrole and have been converted to energy transfer cassettes through a one-pot Knoevenagel condensation. Various BODIPYs containing 2-ketopyrrole unit were also isolated as the side products and one of their BF2 complex was also isolated from these condensation reactions. The fluores- cence quantum yields of these phenylene bridged dimers and trimer are much lower than those of their correspond- ing monomers. A significant decrease of the fluorescence quantum yield was observed in most polar solvents for these dimers and trimer, which may be due to a possible symmetry breaking resulted intramolecular charge transfer （ICT） in the excited state. Efficient energy transfer between the donor and acceptor was observed in these energy transfer cassettes, which could be useful as large pseudo-Stokes shift fluorescent dyes with potential applications in diverse fields.展开更多
Three dipyrrin-containing metal complexes and a boron dipyrromethene（BODIPY）-containing complex were designed and synthesized. The photophysical properties, electrochemical behaviours and photovoltaic performance we...Three dipyrrin-containing metal complexes and a boron dipyrromethene（BODIPY）-containing complex were designed and synthesized. The photophysical properties, electrochemical behaviours and photovoltaic performance were extensively investigated. Density functional theory calculations were also performed on those complexes These complexes, together with electron-acceptor [6,6]-phenyl-C71-butyric acid methyl ester, were utilized for the fabrication of solution-processed bulk heterojunction solar cells as the electron-donor materials. The more efficient electron acceptor BODIPY segment renders a lower energy gap and a relatively better photovoltaic conversion efficiency of 0.58%. These results prove that BODIPY segment has a great potential for constructing efficient organic solar cell materials.展开更多
Tumor oxygen spatial heterogeneity is a critical challenge for the photodynamic inhibition of solid tumors.Development of an intelligent nanoagent to initiate optimal therapeutics according to the localized oxygen lev...Tumor oxygen spatial heterogeneity is a critical challenge for the photodynamic inhibition of solid tumors.Development of an intelligent nanoagent to initiate optimal therapeutics according to the localized oxygen levels is an effective settlement.Herein,we report an activatable nanoagent(BDP-Oxide nanoparticles(NPs))to enable the oxygen auto-adaptive photodynamic/photothermal complementaly treatment.Upon the nanoagent accumulated in the tumor region,the low extracellular pH could trigger the disassociation of the nanoagent to release the phototheranostic agent,BDP-Oxide,which will subsequently afford the fluorescence imaging-guided photodynamic oxidation after it gets into the outer oxygen-rich tumors.Along with the penetration deepening in the solid tumor,furthermore,BDP-Oxide could be reduced into BDP by the cytochrome P450(CYP450)enzymes activated in the low oxygen tension regions of inner hypoxic tumors,which will switch on the photothermal and photoacoustic effects.Overall,the BDP-Oxide NPs-enabled photodynamic/photothermal complementary therapy significantly suppressed the solid tumor growth(inhibition rate of 94.8%).This work proposes an intelligent platform to address the oxygen partial pressure for the optimization of cancer phototherapeutics.展开更多
基金This work is supported by the National Natural Science Foundation of China （Grant Nos. 21372011, 21402001 and 21472002） and Natural Science Foundation of Anhui Province （Grant No. 1508085J07）.
文摘Multichromophoric boron dipyrromethene （BODIPY） dyes have been efficiently synthesized from a one-pot condensation of acyl chloride with 2,4-dimethylpyrrole and have been converted to energy transfer cassettes through a one-pot Knoevenagel condensation. Various BODIPYs containing 2-ketopyrrole unit were also isolated as the side products and one of their BF2 complex was also isolated from these condensation reactions. The fluores- cence quantum yields of these phenylene bridged dimers and trimer are much lower than those of their correspond- ing monomers. A significant decrease of the fluorescence quantum yield was observed in most polar solvents for these dimers and trimer, which may be due to a possible symmetry breaking resulted intramolecular charge transfer （ICT） in the excited state. Efficient energy transfer between the donor and acceptor was observed in these energy transfer cassettes, which could be useful as large pseudo-Stokes shift fluorescent dyes with potential applications in diverse fields.
基金Supported by the National Natural Science Foundation of China（Nos.21403085, 51402286） and the Science and Technology Development Project of Jilin Province, China（No.20130522009JH）.
文摘Three dipyrrin-containing metal complexes and a boron dipyrromethene（BODIPY）-containing complex were designed and synthesized. The photophysical properties, electrochemical behaviours and photovoltaic performance were extensively investigated. Density functional theory calculations were also performed on those complexes These complexes, together with electron-acceptor [6,6]-phenyl-C71-butyric acid methyl ester, were utilized for the fabrication of solution-processed bulk heterojunction solar cells as the electron-donor materials. The more efficient electron acceptor BODIPY segment renders a lower energy gap and a relatively better photovoltaic conversion efficiency of 0.58%. These results prove that BODIPY segment has a great potential for constructing efficient organic solar cell materials.
基金supported by the National Natural Science Foundation of China(No.21771065)Guangdong Special Support Program(No.2017TQ04R138)+3 种基金Science and Technology Program of Guangzhou(No.2019050001)Natural Science Foundation of Guangdong(No.2019A1515012021)Pearl River Nova Program of Guangzhou(No.201806010189)the Major Program of Ningbo Science and Technology Innovation 2025(No.2020Z093).
文摘Tumor oxygen spatial heterogeneity is a critical challenge for the photodynamic inhibition of solid tumors.Development of an intelligent nanoagent to initiate optimal therapeutics according to the localized oxygen levels is an effective settlement.Herein,we report an activatable nanoagent(BDP-Oxide nanoparticles(NPs))to enable the oxygen auto-adaptive photodynamic/photothermal complementaly treatment.Upon the nanoagent accumulated in the tumor region,the low extracellular pH could trigger the disassociation of the nanoagent to release the phototheranostic agent,BDP-Oxide,which will subsequently afford the fluorescence imaging-guided photodynamic oxidation after it gets into the outer oxygen-rich tumors.Along with the penetration deepening in the solid tumor,furthermore,BDP-Oxide could be reduced into BDP by the cytochrome P450(CYP450)enzymes activated in the low oxygen tension regions of inner hypoxic tumors,which will switch on the photothermal and photoacoustic effects.Overall,the BDP-Oxide NPs-enabled photodynamic/photothermal complementary therapy significantly suppressed the solid tumor growth(inhibition rate of 94.8%).This work proposes an intelligent platform to address the oxygen partial pressure for the optimization of cancer phototherapeutics.
