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Case Report: Carnitine Palmitoyl Transferase II (CPT II) Deficiency
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作者 Kathy Po Marius Chivu +1 位作者 Edwin Rosas Balpreet Kaur 《Open Journal of Internal Medicine》 2024年第1期93-101,共9页
Carnitine Palmitoyl Transferase II (CPTII) is a very important enzyme that helps with the oxidation of long-chain fatty acid to produce energy. Deficiency in CPTII will lead to energy deficiency in the case of fasting... Carnitine Palmitoyl Transferase II (CPTII) is a very important enzyme that helps with the oxidation of long-chain fatty acid to produce energy. Deficiency in CPTII will lead to energy deficiency in the case of fasting and the accumulation of the long chain fatty in the body. There are three types of CPT II deficiency, the myopathic form, the severe infantile hepatocardiomuscular form and the lethal neonatal form. They are all inherited as an autosomal recessive. Diagnosis of the CPTII are 1) tandem mass spectrometry (MS/MS) in adult form and 2) CPTII polymorphism (F352C), which is linked to reducing the activity of CPTII in infantile form [1]. Glucose is the primary management and medium-chain fatty acid is an alternative due to the bypass of the CPTII enzyme in the pathway. For the prevention of CPTII deficiency are to avoid long chain fatty acid (C12-fatty acid), fasting, prolonged exercise, known triggers, and certain medications such as anti-epileptics and general anesthesia. During the rhabdomyolysis and myoglobinuria attack, it is very important to maintain hydration to avoid acute renal failure. If, however, renal failure occurs, dialysis is recommended. We present a case of a 27-year-old African American woman with the significant past medical history of CPT II deficiency leading to recurrent rhabdomyolysis and myoglobinuria. Together with all the research studies from diagnosis to treatment of CPTII deficiency will help in clinical management of patients. And this case report will add to the existing case reports of patients who have CPTII deficiency in terms of how we diagnose, how we treat, and how we prevent symptoms from re-occurring. 展开更多
关键词 carnitine Palmitoyl Transferase II (CPTII) Mitochondria Long Chain Fatty Acid Medium Chain Fatty Acid carnitine carnitine Palmitoyl Transferase I (CPTI) Acyl-carnitine BETA-OXIDATION RHABDOMYOLYSIS Myoglobinuria Renal Failure Hypoketotic Hypoglycemia
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Mitochondrial carnitine palmitoyltransferase-Ⅱ dysfunction: A possible novel mechanism for nonalcoholic fatty liver disease in hepatocarcinogenesis
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作者 Min Yao Ping Zhou +2 位作者 Yan-Yan Qin Li Wang Deng-Fu Yao 《World Journal of Gastroenterology》 SCIE CAS 2023年第12期1765-1778,共14页
Nonalcoholic fatty liver disease(NAFLD)or metabolic-associated fatty liver disease has been characterized by the lipid accumulation with injury of hepatocytes and has become one of the most common chronic liver diseas... Nonalcoholic fatty liver disease(NAFLD)or metabolic-associated fatty liver disease has been characterized by the lipid accumulation with injury of hepatocytes and has become one of the most common chronic liver diseases in the world.The complex mechanisms of NAFLD formation are still under identification.Carnitine palmitoyltransferase-Ⅱ(CPT-Ⅱ)on inner mitochondrial membrane(IMM)regulates long chain fatty acidβ-oxidation,and its abnormality has had more and more attention paid to it by basic and clinical research in NAFLD.The sequences of its peptide chain and DNA nucleotides have been identified,and the catalytic activity of CPT-Ⅱ is affected on its gene mutations,deficiency,enzymatic thermal instability,circulating carnitine level and so on.Recently,the CPT-Ⅱ dysfunction has been discovered in models of liver lipid accumulation.Meanwhile,the malignant transformation of hepatocyte-related CD44^(+) stem T cell activation,high levels of tumor-related biomarkers(AFP,GPC3)and abnormal activation of Wnt3a expression as a key signal molecule of the Wnt/β-catenin pathway run parallel to the alterations of hepatocyte pathology.This review focuses on some of the progress of CPT-Ⅱ inactivity on IMM with liver fatty accumulation as a possible novel pathogenesis for NAFLD in hepatocarcinogenesis. 展开更多
关键词 carnitine palmitoyl transferase-II Nonalcoholic fatty liver disease Fatty acidβ-oxidation carnitine Hepatocyte malignant transformation Mitochondrial membrane
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Enabling an Inorganic-Rich Interface via Cationic Surfactant for High-Performance Lithium Metal Batteries 被引量:1
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作者 Zejun Sun Jinlin Yang +18 位作者 Hongfei Xu Chonglai Jiang Yuxiang Niu Xu Lian Yuan Liu Ruiqi Su Dayu Liu Yu Long Meng Wang Jingyu Mao Haotian Yang Baihua Cui Yukun Xiao Ganwen Chen Qi Zhang Zhenxiang Xing Jisheng Pan Gang Wu Wei Chen 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第8期1-17,共17页
An anion-rich electric double layer(EDL)region is favorable for fabricating an inorganic-rich solid-electrolyte interphase(SEI)towards stable lithium metal anode in ester electrolyte.Herein,cetyltrimethylammonium brom... An anion-rich electric double layer(EDL)region is favorable for fabricating an inorganic-rich solid-electrolyte interphase(SEI)towards stable lithium metal anode in ester electrolyte.Herein,cetyltrimethylammonium bromide(CTAB),a cationic surfactant,is adopted to draw more anions into EDL by ionic interactions that shield the repelling force on anions during lithium plating.In situ electrochemical surface-enhanced Raman spectroscopy results combined with molecular dynamics simulations validate the enrichment of NO_(3)^(−)/FSI−anions in the EDL region due to the positively charged CTA^(+).In-depth analysis of SEI structure by X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry results confirmed the formation of the inorganic-rich SEI,which helps improve the kinetics of Li^(+)transfer,lower the charge transfer activation energy,and homogenize Li deposition.As a result,the Li||Li symmetric cell in the designed electrolyte displays a prolongated cycling time from 500 to 1300 h compared to that in the blank electrolyte at 0.5 mA cm^(-2) with a capacity of 1 mAh cm^(-2).Moreover,Li||LiFePO_(4) and Li||LiCoO_(2) with a high cathode mass loading of>10 mg cm^(-2) can be stably cycled over 180 cycles. 展开更多
关键词 cationic surfactant Lithium nitrate additive Solid-electrolyte interphase Electric double layer Lithium metal batteries
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Study of the Temperature-Programmed Desorption of Carbon Dioxide (CO2) on Zeolites X Modified with Bivalent Cations
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作者 Charly Mve Mfoumou Francis Ngoye +4 位作者 Pradel Tonda-Mikiela Ferdinand Evoung Evoung Landry Biyoghe Bi-Ndong Thomas Belin Samuel Mignard 《Journal of Environmental Protection》 CAS 2023年第1期66-82,共17页
Study of physisorbed and chemisorbed carbon dioxide (CO<sub>2</sub>) species was carried out on the NaX zeolite modified by cationic exchanges with bivalent cations (Ca<sup>2+</sup> and Ba<s... Study of physisorbed and chemisorbed carbon dioxide (CO<sub>2</sub>) species was carried out on the NaX zeolite modified by cationic exchanges with bivalent cations (Ca<sup>2+</sup> and Ba<sup>2+</sup>) by temperature-programmed desorption of CO<sub>2</sub> (CO<sub>2</sub>-TPD). Others results were obtained by infrared to complete the study. The results of this research showed, in the physisorption region (213 - 473 K), that the cationic exchanges on NaX zeolite with bivalent cations increase slightly the interactions of CO<sub>2</sub> molecule with adsorbents and/or cationic site. Indeed, the desorption energies of physisorbed CO<sub>2</sub> obtained on the reference zeolite NaX (13.5 kJ·mol<sup>-1</sup>) are lower than that of exchanged zeolites E-CaX and E-BaX (15.77 and 15.17 kJ·mol<sup>-1</sup> respectively). In the chemisorbed CO<sub>2</sub> region (573 - 873 K), the desorption energies related to desorbed species (bidentate carbonates: CO<sub>3</sub>2-</sup>) on the exchanged zeolites E-CaX and E-BaX are about 81 kJ·mol<sup>-1</sup>, higher than the desorbed species (bicarbonates: HCO<sub>3</sub>2-</sup>) on the reference R-NaX (62 kJ·mol<sup>-1</sup>). In addition, the exchanged E-BaX zeolite develops the secondary adsorption sites corresponding to bicarbonates species with desorption energies of 35 kJ·mol<sup>-1</sup> lower to desorption energies of bicarbonates noted on the reference zeolite NaX. 展开更多
关键词 Adsorption Faujasite X Chemisorbed and Physisorbed CO2 Exchanged Zeolites Bivalent cations Temperature-Programmed Desorption (TPD) Infrared
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Development and validation of a UPLC–MS/MS assay for the determination of gemcitabine and its L-carnitine ester derivative in rat plasma and its application in oral pharmacokinetics 被引量:2
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作者 Gang Wang Dongyang Zhao +10 位作者 Hongxiang Chen Dawei Ding Longfa Kou Lifang Sun Chenxia Hao Xincong Li Kai Jia Qiming Kan Xiaohong Liu Zhonggui He Jin Sun 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2017年第5期478-485,共8页
A simple and rapid UPLC–MS/MS method to simultaneously determine gemcitabine and its L-carnitine ester derivative(2’-deoxy-2’, 2’-difluoro-N-((4-amino-4-oxobutanoyl) oxy)-4-(trimethyl amm-onio) butanoate-cytidine,... A simple and rapid UPLC–MS/MS method to simultaneously determine gemcitabine and its L-carnitine ester derivative(2’-deoxy-2’, 2’-difluoro-N-((4-amino-4-oxobutanoyl) oxy)-4-(trimethyl amm-onio) butanoate-cytidine, JDR) in rat plasma was developed and validated.The conventional plasma sample preparation method of nucleoside analogues is solidphase extraction(SPE) which is time-consuming and cost-expensive. In this study, gradient elution with small particles size solid phase was applied to effectively separate gemcitabine and JDR, and protein precipitation pretreatment was adopted to remove plasma protein and extract the analytes with high recovery(>81%). Method validation was performed as per the FDA guidelines, and the standard curves were found to be linear in the range of 5–4000 ng/ml for JDR and 4–4000 ng/ml for gemcitabine, respectively. The lower limit of quantitation(LLOQ)of gemcitabine and JDR was 4 and 5 ng/ml, respectively. The intra-day and inter-day precision and accuracy results were within the acceptable limits. Finally, the developed method was successfully applied to investigate the pharmacokinetic studies of JDR and gemcitabine after oral administration to rats. 展开更多
关键词 GEMCITABINE L-carnitine PRODRUG PHARMACOKINETICS UPLC/MS/MS
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Cation effects in electrocatalytic reduction reactions:Recent advances
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作者 Qinghui Ren Liang Xu +4 位作者 Mengyu Lv Zhiyuan Zhang Zhenhua Li Mingfei Shao Xue Duan 《Chinese Journal of Catalysis》 SCIE CAS CSCD 2024年第8期16-32,共17页
Electrocatalytic reduction reactions,powered by clean energy sources such as solar energy and wind,offer a sustainable method for converting inexpensive feedstocks(e.g.,CO_(2),N_(2)/NO_(x),organics,and O_(2))into high... Electrocatalytic reduction reactions,powered by clean energy sources such as solar energy and wind,offer a sustainable method for converting inexpensive feedstocks(e.g.,CO_(2),N_(2)/NO_(x),organics,and O_(2))into high-value-added chemicals or fuels.The design and modification of electrocatalysts have been widely implemented to improve their performance in these reactions.However,bottle-necks are encountered,making it challenging to further improve performance through catalyst development alone.Recently,cations in the electrolyte have emerged as critical factors for tuning both the activity and product selectivity of reduction reactions.This review summarizes recent advances in understanding the role of cation effects in electrocatalytic reduction reactions.First,we introduce the mechanisms underlying cation effects.We then provide a comprehensive overview of their application in electroreduction reactions.Characterization techniques and theoretical calcula-tion methods for studying cation effects are also discussed.Finally,we address remaining challeng-es and future perspectives in this field.We hope that this review offers fundamental insights and design guidance for utilizing cation effects,thereby advancing their development. 展开更多
关键词 ELECTROCATALYSIS Reduction reaction cation effect MECHANISM APPLIcation
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Waste acid recovery utilizing monovalent cation permselective membranes through selective electrodialysis
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作者 Yanran Zhu Yue Zhou +4 位作者 Qian Chen Rongqiang Fu Zhaoming Liu Liang Ge Tongwen Xu 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第7期45-57,共13页
Selective electrodialysis(SED)has surfaced as a highly promising membrane separation technique in the realm of acid recovery owing to its ability to effectively separate monovalent ions through the utilization of a po... Selective electrodialysis(SED)has surfaced as a highly promising membrane separation technique in the realm of acid recovery owing to its ability to effectively separate monovalent ions through the utilization of a potential difference.However,the current SED process is limited by conventional commercial monovalent cation permselective membranes(MCPMs).This study systematically investigates the use of an independently developed MCPM in the SED process for acid recovery.Various factors such as current density,volume ratio,initial ion concentration,and waste acid systems are considered.The independently developed MCPM offers several advantages over the commercial monovalent selective cation-exchange membrane(CIMS),including higher recovered acid concentration,better ion flux ratio,improved acid recovery efficiency,increased recovered acid purity,and higher current efficiency.The SED process with the MCPM achieves a recovered acid of 95.9%and a concentration of 2.3 mol·L^(–1) in the HCl/FeCl_(2) system,when a current density of 20 mA·cm^(-2) and a volume ratio of 1:2 are applied.Similarly,in the H_(2)SO_(4)/FeSO_(4) system,a purity of over 99%and a concentration of 2.1 mol·L^(–1) can be achieved in the recovered acid.This study thoroughly examines the impact of operation conditions on acid recovery performance in the SED process.The independently developed MCPM demonstrates outstanding acid recovery performance,highlighting its potential for future commercial utilization. 展开更多
关键词 Selective electrodialysis WASTEWATER Monovalent cation permselective membranes SEPARATION RECOVERY
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Fabrication and Properties of a New Reactive Diluent for Cationic UV Curing
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作者 吴正森 黄笔武 +1 位作者 LIU Yuansheng SHEN Han 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS CSCD 2024年第4期1053-1060,共8页
The reactive diluent prepared by siloxane modified Trimethylene oxide can improve the performance of the UV curing system.Therefore,1,7-bis[(3-ethyl-3-methoxyoxacylobutane)propyl]octadecylosiloxane(BEMOPOMTS)was synth... The reactive diluent prepared by siloxane modified Trimethylene oxide can improve the performance of the UV curing system.Therefore,1,7-bis[(3-ethyl-3-methoxyoxacylobutane)propyl]octadecylosiloxane(BEMOPOMTS)was synthesized from diethyl carbonate,trimethylopropanes,allyl bromide,and 1,1,3,3,5,5,7,7-octadecylosiloxane as the main raw materials.BEMOPOMTS can be used as reactive diluents in the field of cationic UV curing.It has good thermal stability,and the addition of BEMOPOMTS significantly improves the tensile strength and elongation at break of epoxy resin.Compared with the pure epoxy resin,adding 20%BEMOPOMTS increased the elastic modulus by 25%to 677 MPa. 展开更多
关键词 UV curing cation curing reactive diluent SILOXANE
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Lithium cation-doped tungsten oxide as a bidirectional nanocatalyst for lithium-sulfur batteries with high areal capacity
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作者 Biying Wang Ke Chen +3 位作者 Jieying Liang Zhichun Yu Da-Wei Wang Ruopian Fang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第11期406-413,共8页
Lithium-sulfur(Li-S) batteries are promising for high energy-storage applications but suffer from sluggish conversion reaction kinetics and substantial lithium sulfide(Li_(2)S) oxidation barrier,especially under high ... Lithium-sulfur(Li-S) batteries are promising for high energy-storage applications but suffer from sluggish conversion reaction kinetics and substantial lithium sulfide(Li_(2)S) oxidation barrier,especially under high sulfur loadings.Here,we report a Li cation-doped tungsten oxide(Li_(x)WO_(x)) electrocatalyst that efficiently accelerates the S■HLi_(2)S interconversion kinetics.The incorporation of Li dopants into WO_(x) cationic vacancies enables bidirectional electrocatalytic activity for both polysulfide reduction and Li_(2)S oxidation,along with enhanced Li^(+) diffusion.In conjunction with theoretical calculations,it is discovered that the improved electrocatalytic activity originates from the Li dopant-induced geometric and electronic structural optimization of the Li_(x)WO_(x),which promotes the anchoring of sulfur species at favourable adsorption sites while facilitating the charge transfer kinetics.Consequently,Li-S cells with the Li_(x)WO_(x) bidirectional electrocatalyst show stable cycling performance and high sulfur utilization under high sulfur loadings.Our approach provides insights into cation engineering as an effective electrocatalyst design strategy for advancing high-performance Li-S batteries. 展开更多
关键词 cation engineering Electrocatalysis Polysulfide conversion Lithium sulfide oxidation Lithium-sulfur batteries
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Exploring the Cation Regulation Mechanism for Interfacial Water Involved in the Hydrogen Evolution Reaction by In Situ Raman Spectroscopy
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作者 Xueqiu You Dongao Zhang +4 位作者 Xia‑Guang Zhang Xiangyu Li Jing‑Hua Tian Yao‑Hui Wang Jian‑Feng Li 《Nano-Micro Letters》 SCIE EI CSCD 2024年第3期303-312,共10页
Interfacial water molecules are the most important participants in the hydrogen evolution reaction(HER).Hence,understanding the behavior and role that interfacial water plays will ultimately reveal the HER mechanism.U... Interfacial water molecules are the most important participants in the hydrogen evolution reaction(HER).Hence,understanding the behavior and role that interfacial water plays will ultimately reveal the HER mechanism.Unfortunately,investigating interfacial water is extremely challenging owing to the interference caused by bulk water molecules and complexity of the interfacial environment.Here,the behaviors of interfacial water in different cationic electrolytes on Pd surfaces were investigated by the electrochemistry,in situ core-shell nanostructure enhanced Raman spectroscopy and theoretical simulation techniques.Direct spectral evidence reveals a red shift in the frequency and a decrease in the intensity of interfacial water as the potential is shifted in the positively direction.When comparing the different cation electrolyte systems at a given potential,the frequency of the interfacial water peak increases in the specified order:Li+<Na^(+)<K^(+)<Ca^(2+)<Sr^(2+).The structure of interfacial water was optimized by adjusting the radius,valence,and concentration of cation to form the two-H down structure.This unique interfacial water structure will improve the charge transfer efficiency between the water and electrode further enhancing the HER performance.Therefore,local cation tuning strategies can be used to improve the HER performance by optimizing the interfacial water structure. 展开更多
关键词 In situ Raman Interfacial water Hydrogen evolution reaction cations
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Cationic ordering transition in oxygen-redox layered oxide cathodes
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作者 Xinyan Li Ang Gao +10 位作者 Qinghua Zhang Hao Yu Pengxiang Ji Dongdong Xiao Xuefeng Wang Dong Su Xiaohui Rong Xiqian Yu Hong Li Yong-Sheng Hu Lin Gu 《Carbon Energy》 SCIE EI CAS CSCD 2024年第1期197-206,共10页
Understanding the structural origin of the competition between oxygen 2p and transition-metal 3d orbitals in oxygen-redox(OR)layered oxides is eminently desirable for exploring reversible and high-energy-density Li/Na... Understanding the structural origin of the competition between oxygen 2p and transition-metal 3d orbitals in oxygen-redox(OR)layered oxides is eminently desirable for exploring reversible and high-energy-density Li/Na-ion cathodes.Here,we reveal the correlation between cationic ordering transition and OR degradation in ribbon-ordered P3-Na_(0.6)Li_(0.2)Mn_(0.8)O_(2) via in situ structural analysis.Comparing two different voltage windows,the OR capacity can be improved approximately twofold when suppressing the in-plane cationic ordering transition.We find that the intralayer cationic migration is promoted by electrochemical reduction from Mn^(4+)to Jahn–Teller Mn^(3+)and the concomitant NaO_(6) stacking transformation from triangular prisms to octahedra,resulting in the loss of ribbon ordering and electrochemical decay.First-principles calculations reveal that Mn^(4+)/Mn^(3+)charge ordering and alignment of the degenerate eg orbital induce lattice-level collective Jahn–Teller distortion,which favors intralayer Mn-ion migration and thereby accelerates OR degradation.These findings unravel the relationship between in-plane cationic ordering and OR reversibility and highlight the importance of superstructure protection for the rational design of reversible OR-active layered oxide cathodes. 展开更多
关键词 cationic ordering layered oxide cathodes oxygen redox sodium-ion batteries
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Enhancing selectivity in acidic CO_(2) electrolysis:Cation effects and catalyst innovation
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作者 Zichao Huang Tinghui Yang +4 位作者 Yingbing Zhang Chaoqun Guan Wenke Gui Min Kuang Jianping Yang 《Chinese Journal of Catalysis》 SCIE CAS CSCD 2024年第8期61-80,共20页
The electrochemical reduction of CO_(2)(eCO_(2)R)under ambient conditions is crucial for reducing carbon emissions and achieving carbon neutrality.Despite progress with alkaline and neutral electrolytes,their efficien... The electrochemical reduction of CO_(2)(eCO_(2)R)under ambient conditions is crucial for reducing carbon emissions and achieving carbon neutrality.Despite progress with alkaline and neutral electrolytes,their efficiency is limited by(bi)carbonates formation.Acidic media have emerged as a solution,addressing the(bi)carbonates challenge but introducing the issue of the hydrogen evolu-tion reaction(HER),which reduces CO_(2) conversion efficiency in acidic environments.This review focuses on enhancing the selectivity of acidic CO_(2) electrolysis.It commences with an overview of the latest advancements in acidic CO_(2) electrolysis,focusing on product selectivity and electrocatalytic activity enhancements.It then delves into the critical factors shaping selectivity in acidic CO_(2) electrolysis,with a special emphasis on the influence of cations and catalyst design.Finally,the research challenges and personal perspectives of acidic CO_(2) electrolysis are suggested. 展开更多
关键词 ACIDIC CO_(2) electrolysis High selectivity cation effects Catalyst design Competitive HER
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Atomically Adjustable Rhodium Catalyst Synthesis with Outstanding Mass Activity via Surface-Li mi ted Cation Exchange
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作者 Hak Hyeon Lee Dong Su Kim +3 位作者 Swagotom Sarker Ji Hoon Choi Ho Seong Lee Hyung Koun Cho 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2024年第2期83-92,共10页
Rh has been widely studied as a catalyst for the promising hydrazine oxidation reaction that can replace oxygen evolution reactions for boosting hydrogen production from hydrazine-containing wastewater.Despite Rh bein... Rh has been widely studied as a catalyst for the promising hydrazine oxidation reaction that can replace oxygen evolution reactions for boosting hydrogen production from hydrazine-containing wastewater.Despite Rh being expensive,only a few studies have examined its electrocatalytic mass activity.Herein,surface-limited cation exchange and electrochemical activation processes are designed to remarkably enhance the mass activity of Rh.Rh atoms were readily replaced at the Ni sites on the surface of NiOOH electrodes by cation exchange,and the resulting RhOOH compounds were activated by the electrochemical reduction process.The cation exchange-derived Rh catalysts exhibited particle sizes not exceeding 2 nm without agglomeration,indicating a decrease in the number of inactive inner Rh atoms.Consequently,an improved mass activity of 30 A mg_(Rh)^(-1)was achieved at 0.4 V versus reversible hydrogen electrode.Furthermore,the two-electrode system employing the same CE-derived Rh electrodes achieved overall hydrazine splitting over 36 h at a stable low voltage.The proposed surface-limited CE process is an effective method for reducing inactive atoms of expensive noble metal catalysts. 展开更多
关键词 cation exchange synthesis electrochemical metallization hydrazine oxidation reaction mass activity rhodium catalyst
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Identification of Mulberry Bacterial Blight Caused by Klebsiella oxytoca in Bazhong,Sichuan,China
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作者 Yuan Huang Jia Wei +8 位作者 Peigang Liu Yan Zhu Tianbao Lin Zhiqiang Lv Yijun Li Mei Zong Yun Zhou Junshan Gao Zilong Xu 《Phyton-International Journal of Experimental Botany》 SCIE 2024年第8期1995-2008,共14页
To provide a scientific basis for controlling mulberry bacterial blight in Bazhong,Sichuan,China(BSC),this study aimed to isolate and purify pathogenic bacteria from diseased branches of mulberry trees in the region a... To provide a scientific basis for controlling mulberry bacterial blight in Bazhong,Sichuan,China(BSC),this study aimed to isolate and purify pathogenic bacteria from diseased branches of mulberry trees in the region and to clarify their taxonomic status using morphological observation,physiological and biochemical detection,molecular-level identification,and the construction of a phylogenetic tree.A total of 218 bacterial strains were isolated from samples of diseased mulberry branches.Of these,7 strains were identified as pathogenic bacteria based on pathogenicity tests conducted in accordance with Koch’s postulates.Preliminary findings from the analysis of the 16S rRNA sequence indicated that the 7 pathogenic bacteria are members of Klebsiella spp.Morphological observation revealed that the pathogenic bacteria were oval-shaped and had capsules but no spores.They could secrete pectinase,cellulase,and protease and were able to utilize D-glucose,D-mannose,D-maltose,and D-Cellobiose.The 7 strains of pathogenic bacteria exhibited the highest homology with Klebsiella oxytoca.This study identifies Klebsiella oxytoca as the causative agent of mulberry bacterial blight in BSC,laying the foundation for the prevention and control of this pathogen and further investigation into its pathogenic mechanism. 展开更多
关键词 MULBERRY bacterial blight pathogenic identification Klebsiella spp. Klebsiella oxytoca
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Application of Transgenic Technology in Identification for Gene Function on Grasses
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作者 Lijun Zhang Ying Liu +1 位作者 Yushou Ma Xinyou Wang Qinghai 《Phyton-International Journal of Experimental Botany》 SCIE 2024年第8期1913-1941,共29页
Perennial grasses have developed intricate mechanisms to adapt to diverse environments,enabling their resistance to various biotic and abiotic stressors.These mechanisms arise from strong natural selection that contri... Perennial grasses have developed intricate mechanisms to adapt to diverse environments,enabling their resistance to various biotic and abiotic stressors.These mechanisms arise from strong natural selection that contributes to enhancing the adaptation of forage plants to various stress conditions.Methods such as antisense RNA technology,CRISPR/Cas9 screening,virus-induced gene silencing,and transgenic technology,are commonly utilized for investigating the stress response functionalities of grass genes in both warm-season and cool-season varieties.This review focuses on the functional identification of stress-resistance genes and regulatory elements in grasses.It synthesizes recent studies on mining functional genes,regulatory genes,and protein kinase-like signaling factors involved in stress responses in grasses.Additionally,the review outlines future research directions,providing theoretical support and references for further exploration of(i)molecular mechanisms underlying grass stress responses,(ii)cultivation and domestication of herbage,(iii)development of high-yield varieties resistant to stress,and(iv)mechanisms and breeding strategies for stress resistance in grasses. 展开更多
关键词 Grasses regulatory genes protein kinase-like signaling factors gene function identification resistance breeding
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Structural Modal Parameter Recognition and Related Damage Identification Methods under Environmental Excitations: A Review
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作者 Chao Zhang Shang-Xi Lai Hua-Ping Wang 《Structural Durability & Health Monitoring》 EI 2025年第1期25-54,共30页
Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the structure.Therefore,it is particularly significant to identify the structural modal parameters accordi... Modal parameters can accurately characterize the structural dynamic properties and assess the physical state of the structure.Therefore,it is particularly significant to identify the structural modal parameters according to the monitoring data information in the structural health monitoring(SHM)system,so as to provide a scientific basis for structural damage identification and dynamic model modification.In view of this,this paper reviews methods for identifying structural modal parameters under environmental excitation and briefly describes how to identify structural damages based on the derived modal parameters.The paper primarily introduces data-driven modal parameter recognition methods(e.g.,time-domain,frequency-domain,and time-frequency-domain methods,etc.),briefly describes damage identification methods based on the variations of modal parameters(e.g.,natural frequency,modal shapes,and curvature modal shapes,etc.)and modal validation methods(e.g.,Stability Diagram and Modal Assurance Criterion,etc.).The current status of the application of artificial intelligence(AI)methods in the direction of modal parameter recognition and damage identification is further discussed.Based on the pre-vious analysis,the main development trends of structural modal parameter recognition and damage identification methods are given to provide scientific references for the optimized design and functional upgrading of SHM systems. 展开更多
关键词 Structural health monitoring data information modal parameters damage identification AI method
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L-Carnitine拮抗培养心肌细胞缺氧/复氧损伤 被引量:10
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作者 朱光旭 余争平 +5 位作者 谢燕 楼淑芬 王小华 杨明杰 杨学森 周舟 《第三军医大学学报》 CAS CSCD 北大核心 2001年第12期1410-1413,共4页
目的 探讨L Carnitine对心肌细胞缺氧 /复氧损伤的防护作用及其可能的机制。方法 以原代培养新生鼠心肌细胞建立缺氧 /复氧损伤模型 ,观察不同剂量L Carnitine处理后细胞增殖活性、凋亡细胞百分率及DNA断片化率 ,作为反映L Carnitine... 目的 探讨L Carnitine对心肌细胞缺氧 /复氧损伤的防护作用及其可能的机制。方法 以原代培养新生鼠心肌细胞建立缺氧 /复氧损伤模型 ,观察不同剂量L Carnitine处理后细胞增殖活性、凋亡细胞百分率及DNA断片化率 ,作为反映L Carnitine对心肌细胞缺氧 /复氧损伤防护作用及其机制的指标。结果 在 5~ 5 0 0 0nmol/L范围内 ,L Carnitine预处理对培养心肌细胞缺氧 /复氧损伤均显示保护效应 ;在 5、5 0及 5 0 0nmol/L时均显著降低DNA断片化率 ;L Carnitine在 5 0nmol/L时与单纯缺氧 /复氧组比较可显著降低凋亡细胞百分率。结论 缺氧 /复氧对心肌细胞的影响之一是可诱导心肌细胞凋亡 ;L Carnitine对培养心肌细胞培养缺氧/复氧损伤具有防护作用 ,其机制可能与抑制缺氧 /复氧诱导细胞凋亡有关。 展开更多
关键词 缺氧复氧 细胞凋亡 细胞增殖活性 L-carnitine
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缺氧复氧对培养仔鼠心肌细胞NRF1和mtTFA表达的影响与L-carnitine保护作用 被引量:7
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作者 谢燕 朱光旭 +2 位作者 江海洪 周舟 余争平 《第三军医大学学报》 CAS CSCD 北大核心 2001年第12期1399-1402,共4页
目的 探讨培养仔鼠心肌细胞缺氧复氧能量代谢损伤的机制及L 肉毒碱 (L carnitine )的保护作用。方法 以原代培养仔鼠心肌细胞建立缺氧复氧损伤模型 ,应用高效液相色谱检测心肌细胞内ATP、ADP、AMP含量 ;应用RT PCR方法检测心肌细胞核... 目的 探讨培养仔鼠心肌细胞缺氧复氧能量代谢损伤的机制及L 肉毒碱 (L carnitine )的保护作用。方法 以原代培养仔鼠心肌细胞建立缺氧复氧损伤模型 ,应用高效液相色谱检测心肌细胞内ATP、ADP、AMP含量 ;应用RT PCR方法检测心肌细胞核呼吸因子 (Nuclearrespiratoryfactor1 ,NRF1 )和线粒体转录因子A(MitochondrialtranscriptionfactorA ,mtTFA)mRNA表达。结果 与正常对照组比较 ,培养的心肌细胞缺氧 2 4h复氧 0、2、4、8h ,心肌细胞ATP、ADP含量均明显下降。与单纯缺氧复氧组比较 ,L carnitine预处理组心肌细胞缺氧复氧后ATP含量明显提升 ;培养的心肌细胞缺氧 2 4h ,NRF1和mtTFAmRNA明显降低 ,复氧 2、4、8h进一步降低。L carnitine预处理使缺氧 2 4h复氧 4h的心肌细胞NRF1和mtTFAmRNA表达分别提升 1 5 %和 2 0 %。结论 心肌细胞缺氧复氧过程中能量代谢明显降低 ,其损伤可能与NRF1和mtTFAmRNA表达下调有关 ;L carnitine对培养仔鼠心肌细胞缺氧复氧能量代谢损伤具有保护作用 ,其机制可能是L carnitine从转录调控水平改善了缺氧复氧过程中心肌细胞的能量代谢。 展开更多
关键词 缺氧复氧 能量代谢 NRF1 mtTFA L-肉毒碱
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L-carnitine对缺氧/复氧新生大鼠心肌细胞能量生成及CPT-Ⅱ mRNA表达的影响 被引量:5
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作者 朱光旭 谢燕 +3 位作者 王小华 周舟 楼淑芬 余争平 《第三军医大学学报》 CAS CSCD 北大核心 2004年第3期201-204,共4页
目的 探讨L 肉毒碱 (L carnitine ,L Car)对缺氧 复氧培养新生大鼠心肌细胞能量生成的影响及其机制。方法 以原代培养新生大鼠心肌细胞建立缺氧 复氧损伤模型 ,高效液相色谱检测单纯缺氧 复氧以及L Car预处理缺氧 复氧心肌细胞ATP... 目的 探讨L 肉毒碱 (L carnitine ,L Car)对缺氧 复氧培养新生大鼠心肌细胞能量生成的影响及其机制。方法 以原代培养新生大鼠心肌细胞建立缺氧 复氧损伤模型 ,高效液相色谱检测单纯缺氧 复氧以及L Car预处理缺氧 复氧心肌细胞ATP、ADP、AMP生成改变 ;RT PCR方法检测心肌细胞肉毒碱脂酰基转移酶 Ⅱ (carnitinepalmitoyltransferase Ⅱ ,CPT Ⅱ )mRNA表达。结果 与正常对照组比较 ,培养心肌细胞缺氧 2 4h复氧 0、2、4、8h后 ,心肌细胞ATP、ADP均明显下降。与单纯缺氧 复氧组比较 ,L Car预处理组心肌细胞缺氧 复氧后ATP含量明显增高 ;培养心肌细胞缺氧 2 4h后 ,CPT ⅡmRNA表达除复氧 2h有所上升外 ,复氧 4、8h表达渐次降低。L Car预处理使缺氧 2 4h复氧 4h心肌细胞CPT ⅡmRNA表达呈浓度依赖性增高 ,5 0nmol L处理组CPT ⅡmRNA表达显著高于 0nmol L处理组。结论 心肌细胞缺氧 复氧过程中能量生成明显降低 ,其损伤可能与三羧酸循环中呼吸酶CPT Ⅱ表达降低有关 ;L Car对培养仔鼠心肌细胞缺氧复氧损伤具有显著保护作用 ,其机制可能是与L Car从转录调控水平改善CPT Ⅱ合成有关。 展开更多
关键词 缺氧/复氧 L-camitine 能量代谢 CPT-Ⅱ 心肌细胞 新生大鼠
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A study of the ameliorating effects of carnitine on hepatic steatosis induced by total parenteral nutrition in rats 被引量:6
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作者 LIANG Li Jian, YIN Xiao Yu, LUO Shi Min, ZHENG Jin Fang, LU Ming De and HUANG Jie Fu 《World Journal of Gastroenterology》 SCIE CAS CSCD 1999年第4期40-43,共4页
AIM To investigate the effects of carnitine on ameliorating hepatic steatosis induced by total parenteral nutrition (TPN) in animal model. METHODS Eighteen normal Wistar rats and 19 cirrhotic Wistar rats induced by... AIM To investigate the effects of carnitine on ameliorating hepatic steatosis induced by total parenteral nutrition (TPN) in animal model. METHODS Eighteen normal Wistar rats and 19 cirrhotic Wistar rats induced by carbon tetrachloride were randomly divided into three groups, i.e., free access to food and drink (group A), TPN (group B) and TPN+carnitine (group C) for one week, respectively. Hepatic function, histology and its fat content were determined on the 7th day. RESULTS Hepatic triglyceride (TG) and cholesterol (CHO) contents were significantly higher in groups B and C than in group A, and significantly lower in group C than in group B in both normal and cirrhotic rats (all P <0 05). Histopathological examinations revealed that hepatic steatosis was more severe in group B than in group C in both normal and cirrhotic rats. CONCLUSION Carnitine can ameliorate hepatic steatosis associated with TPN in both non cirrhotic and cirrhotic rats. 展开更多
关键词 carnitine HEPATIC STEATOSIS TOTAL PARENTERAL NUTRITION rats
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