La_ 1-xSr_xGa_ 1-yMg_yO_ 3-δ(LSGM)electrolyte material was synthesized by solid-state reaction method. The microstructure characteristics were tested via X-ray diffraction(XRD), scanning electron microcopy (SEM), and...La_ 1-xSr_xGa_ 1-yMg_yO_ 3-δ(LSGM)electrolyte material was synthesized by solid-state reaction method. The microstructure characteristics were tested via X-ray diffraction(XRD), scanning electron microcopy (SEM), and energy dispersive spectroscopy (EDS). XRD patterns indicate that perovskite phase began to form when the mixed materials were sintered at 1000 ℃, and the material has a pure LSGM perovskite phase when the mixed materials were sintered at 1450 ℃ in air for 24 h. No chemical reaction between LSGM electrolyte material and La_ 1-xSr_xMn_ 1-yCr_yO_ 3-δ(LSMC) anode material or La_ 1-xSr_xFe_ 1-yCo_yO_ 3-δ (LSFC) cathode material was detected after the mixed materials consisting of LSGM and LSMC or LSFC was sintered at 1200 ℃ in air for 15 h respectively, which shows that LSGM electrolyte material has excellent chemical compatibility with LSMC anode and LSFC cathode materials. According to SEM, LSMC anode film and cathode composite film of LSFC and LSMC prepared using direct painting method by sintering at 1150 ℃ are both porous and well cohered on LSGM electrolyte substrate.展开更多
Background Recombinant human(rh)IGF-1/IGFBP-3 protein complex,administered as a continuous intravenous infusion in preterm infants,is being studied for the prevention of complications of prematurity.Methods We conduct...Background Recombinant human(rh)IGF-1/IGFBP-3 protein complex,administered as a continuous intravenous infusion in preterm infants,is being studied for the prevention of complications of prematurity.Methods We conducted in vitro studies to evaluate the physical and chemical compatibility of rhIGF-1/IGFBP-3 with medications routinely administered to preterm neonates.In vitro mixing of rhIGF-1/IGFBP-3 drug product with small-molecule test medications plus corresponding controls was performed.Physical compatibility was defined as no color change,precipitation,turbidity,gas evolution,no clinically relevant change in pH/osmolality or loss in medication content.Chemical compatibility of small molecules was assessed using liquid chromatography(e.g.,reverse-phase HPLC and ion chromatography),with incompatibility defined as loss of concentration of≥10%.A risk evaluation was conducted for each medication based on in vitro compatibility data and potential for chemical modification.Results In vitro physical compatibility was established for 11/19 medications:caffeine citrate,fentanyl,fluconazole,gen-tamicin,insulin,intravenous fat emulsion,midazolam,morphine sulfate,custom-mixed parenteral nutrition solution(with/without electrolytes),parenteral nutrition solution+intravenous fat emulsion,and vancomycin(dosed from a 5 mg/mL solu-tion),but not for 8/19 medications:amikacin,ampicillin,dopamine,dobutamine,furosemide,meropenem,norepinephrine,and penicillin G,largely owing to changes in pH after mixing.Small-molecule compatibility was unaffected post-mixing,with no loss of small-molecule content.For physically compatible medications,risk analyses confirmed low probability and severity of a risk event.Conclusion Co-administration of rhIGF-1/rhIGFBP-3 drug product with various medications was assessed by in vitro studies using case-by-case risk analyses to determine the suitability of the products for co-administration.展开更多
Searching for insensitive melt-castable energetic materials is still facing great challenges.In this work,we developed a promising strategy that is regulating the ratio of non-covalent interaction by fluorine atoms to...Searching for insensitive melt-castable energetic materials is still facing great challenges.In this work,we developed a promising strategy that is regulating the ratio of non-covalent interaction by fluorine atoms to regulate the melting point to develop new melt-castable energetic materials.Using this method,a highly sym-metric 1,2-difluoro-4,5-dinitrobenzene(DFDNB)was synthesized in one step and fully characterized.DFDNB has a desirable melting point(83.2℃),high decomposition temperature(>400℃),acceptable detonation properties(6786 m s^(-1),21.5 GPa)but superior safety performance(>40 J,>360 N),and excellent chemical compatibility with 1,3,5-trinitro-1,3,5-triazine(RDX)that make it a promising insensitive melt-castable energetic material.A detailed study based on crystal stacking,electrostatic potential,and intermolecular weak interactions in DFDNB and its isomers or analogs demonstrates that non-covalent interactions including the C-F…H,N-O…H hydrogen bonding,and C-F…O halogen-like bonding play an important role in regulating the melting point.展开更多
As candidate thermal/environmental barrier coatings(T/EBCs),the structure characteristics and comprehensive properties of monoclinic-prime(m')RETaO4(RE=Yb,Lu,Sc)with excellent Al2O3/SiO2 chemical compatibility are...As candidate thermal/environmental barrier coatings(T/EBCs),the structure characteristics and comprehensive properties of monoclinic-prime(m')RETaO4(RE=Yb,Lu,Sc)with excellent Al2O3/SiO2 chemical compatibility are studied.Excellent thermal insulation protection will be provided by m'RETaO4 due to their low thermal conductivity(~1.6 Wm^-1 K^-1,900℃)and prominent thermal radiation resistance,which is much better than those of YSZ(~2.5 Wm^-1 K^-1,1000℃)and La-12 Zr2O7(~2.0 Wm^-1 K,900℃).The thermal expansion coefficients(TECs)are 3.0–8.0×10^-6 K^-1(200-1200℃),which is suitable for T/EBCs applications.Furthermore,absence of phase transition and extraordinary chemical compatibility with Al2O3/SiO2 up to 1500℃indicate the potential application prospect.The documented governing mechanisms of m'RETaO4 properties will enable researchers to promote their application in the future investigation.展开更多
文摘La_ 1-xSr_xGa_ 1-yMg_yO_ 3-δ(LSGM)electrolyte material was synthesized by solid-state reaction method. The microstructure characteristics were tested via X-ray diffraction(XRD), scanning electron microcopy (SEM), and energy dispersive spectroscopy (EDS). XRD patterns indicate that perovskite phase began to form when the mixed materials were sintered at 1000 ℃, and the material has a pure LSGM perovskite phase when the mixed materials were sintered at 1450 ℃ in air for 24 h. No chemical reaction between LSGM electrolyte material and La_ 1-xSr_xMn_ 1-yCr_yO_ 3-δ(LSMC) anode material or La_ 1-xSr_xFe_ 1-yCo_yO_ 3-δ (LSFC) cathode material was detected after the mixed materials consisting of LSGM and LSMC or LSFC was sintered at 1200 ℃ in air for 15 h respectively, which shows that LSGM electrolyte material has excellent chemical compatibility with LSMC anode and LSFC cathode materials. According to SEM, LSMC anode film and cathode composite film of LSFC and LSMC prepared using direct painting method by sintering at 1150 ℃ are both porous and well cohered on LSGM electrolyte substrate.
文摘Background Recombinant human(rh)IGF-1/IGFBP-3 protein complex,administered as a continuous intravenous infusion in preterm infants,is being studied for the prevention of complications of prematurity.Methods We conducted in vitro studies to evaluate the physical and chemical compatibility of rhIGF-1/IGFBP-3 with medications routinely administered to preterm neonates.In vitro mixing of rhIGF-1/IGFBP-3 drug product with small-molecule test medications plus corresponding controls was performed.Physical compatibility was defined as no color change,precipitation,turbidity,gas evolution,no clinically relevant change in pH/osmolality or loss in medication content.Chemical compatibility of small molecules was assessed using liquid chromatography(e.g.,reverse-phase HPLC and ion chromatography),with incompatibility defined as loss of concentration of≥10%.A risk evaluation was conducted for each medication based on in vitro compatibility data and potential for chemical modification.Results In vitro physical compatibility was established for 11/19 medications:caffeine citrate,fentanyl,fluconazole,gen-tamicin,insulin,intravenous fat emulsion,midazolam,morphine sulfate,custom-mixed parenteral nutrition solution(with/without electrolytes),parenteral nutrition solution+intravenous fat emulsion,and vancomycin(dosed from a 5 mg/mL solu-tion),but not for 8/19 medications:amikacin,ampicillin,dopamine,dobutamine,furosemide,meropenem,norepinephrine,and penicillin G,largely owing to changes in pH after mixing.Small-molecule compatibility was unaffected post-mixing,with no loss of small-molecule content.For physically compatible medications,risk analyses confirmed low probability and severity of a risk event.Conclusion Co-administration of rhIGF-1/rhIGFBP-3 drug product with various medications was assessed by in vitro studies using case-by-case risk analyses to determine the suitability of the products for co-administration.
基金supported by the National Natural Science Foundation of China(No.22105023).
文摘Searching for insensitive melt-castable energetic materials is still facing great challenges.In this work,we developed a promising strategy that is regulating the ratio of non-covalent interaction by fluorine atoms to regulate the melting point to develop new melt-castable energetic materials.Using this method,a highly sym-metric 1,2-difluoro-4,5-dinitrobenzene(DFDNB)was synthesized in one step and fully characterized.DFDNB has a desirable melting point(83.2℃),high decomposition temperature(>400℃),acceptable detonation properties(6786 m s^(-1),21.5 GPa)but superior safety performance(>40 J,>360 N),and excellent chemical compatibility with 1,3,5-trinitro-1,3,5-triazine(RDX)that make it a promising insensitive melt-castable energetic material.A detailed study based on crystal stacking,electrostatic potential,and intermolecular weak interactions in DFDNB and its isomers or analogs demonstrates that non-covalent interactions including the C-F…H,N-O…H hydrogen bonding,and C-F…O halogen-like bonding play an important role in regulating the melting point.
基金under the support of the Natural Science Foundation of China(No.51762028,No.91960103)Materials Genome Engineering of Rare and Precious Metal of Yunnan Province(No.2018ZE019)。
文摘As candidate thermal/environmental barrier coatings(T/EBCs),the structure characteristics and comprehensive properties of monoclinic-prime(m')RETaO4(RE=Yb,Lu,Sc)with excellent Al2O3/SiO2 chemical compatibility are studied.Excellent thermal insulation protection will be provided by m'RETaO4 due to their low thermal conductivity(~1.6 Wm^-1 K^-1,900℃)and prominent thermal radiation resistance,which is much better than those of YSZ(~2.5 Wm^-1 K^-1,1000℃)and La-12 Zr2O7(~2.0 Wm^-1 K,900℃).The thermal expansion coefficients(TECs)are 3.0–8.0×10^-6 K^-1(200-1200℃),which is suitable for T/EBCs applications.Furthermore,absence of phase transition and extraordinary chemical compatibility with Al2O3/SiO2 up to 1500℃indicate the potential application prospect.The documented governing mechanisms of m'RETaO4 properties will enable researchers to promote their application in the future investigation.
