Satellite glial cells are unique glial cells that surround the cell body of primary sensory neurons.An increasing body of evidence suggests that in the presence of inflammation and nerve damage,a significant number of...Satellite glial cells are unique glial cells that surround the cell body of primary sensory neurons.An increasing body of evidence suggests that in the presence of inflammation and nerve damage,a significant number of satellite glial cells become activated,thus triggering a series of functional changes.This suggests that satellite glial cells are closely related to the occurrence of chronic pain.In this review,we first summarize the morphological structure,molecular markers,and physiological functions of satellite glial cells.Then,we clarify the multiple key roles of satellite glial cells in chronic pain,including gap junction hemichannel Cx43,membrane channel Pannexin1,K channel subunit 4.1,ATP,purinergic P2 receptors,and a series of additional factors and their receptors,including tumor necrosis factor,glutamate,endothelin,and bradykinin.Finally,we propose that future research should focus on the specific sorting of satellite glial cells,and identify genomic differences between physiological and pathological conditions.This review provides an important perspective for clarifying mechanisms underlying the peripheral regulation of chronic pain and will facilitate the formulation of new treatment plans for chronic pain.展开更多
Background: Chronic pain is a major public health issue. It is a complex condition comprising biological, social and psychological elements, which can be challenging to manage. Forgiveness is a recognised effective in...Background: Chronic pain is a major public health issue. It is a complex condition comprising biological, social and psychological elements, which can be challenging to manage. Forgiveness is a recognised effective intervention in various health conditions. Research has shown promising results using forgiveness as an intervention in the management of pain. This study aims to examine the relationship between forgiveness and other variables in patients suffering from chronic pain in the setting of a chronic pain clinic. Methods: Institutional ethical approval was granted for this study. Patients attending a chronic pain clinic for the first time were invited to complete a questionnaire comprising a brief socio-demographic survey and questionnaires including the Heartland Forgiveness Scale, Hospital Anxiety and Depression Scale, Pain and Anxiety Symptoms Scale and Perceived Injustice. Results: 104 adult patients were included. The mean age was 59 years. Back pain was the most common chronic pain presentation. The Heartland Forgiveness Scale (HFS) was found to have a good internal consistency among the Irish population. This study found that 55% of patients attending the pain clinic were not forgiving. Negative correlations were identified between forgiveness and pain, and forgiveness and injustice. Conclusion: The majority of patients attending a chronic pain clinic were not forgiving as measured on the HFS. There was a negative correlation between forgiveness and pain. The results have shown that forgiveness could be beneficial as a therapeutic intervention among patients attending a chronic pain clinic.展开更多
Nitric oxide(NO)/cyclic guanosine 3′,5′-monophosphate(cGMP) signaling has been shown to act as a mediator involved in pain transmission and processing. In this review, we summarize and discuss the mechanisms of the ...Nitric oxide(NO)/cyclic guanosine 3′,5′-monophosphate(cGMP) signaling has been shown to act as a mediator involved in pain transmission and processing. In this review, we summarize and discuss the mechanisms of the NO/cGMP signaling pathway involved in chronic pain, including neuropathic pain, bone cancer pain, inflammatory pain, and morphine tolerance. The main process in the NO/cGMP signaling pathway in cells involves NO activating soluble guanylate cyclase, which leads to subsequent production of cGMP. cGMP then activates cGMP-dependent protein kinase(PKG), resulting in the activation of multiple targets such as the opening of ATP-sensitive K+ channels. The activation of NO/cGMP signaling in the spinal cord evidently induces upregulation of downstream molecules, as well as reactive astrogliosis and microglial polarization which participate in the process of chronic pain. In dorsal root ganglion neurons, natriuretic peptide binds to particulate guanylyl cyclase, generating and further activating the cGMP/PKG pathway, and it also contributes to the development of chronic pain. Upregulation of multiple receptors is involved in activation of the NO/cGMP signaling pathway in various pain models. Notably the NO/cGMP signaling pathway induces expression of downstream effectors, exerting both algesic and analgesic effects in neuropathic pain and inflammatory pain. These findings suggest that activation of NO/cGMP signaling plays a constituent role in the development of chronic pain, and this signaling pathway with dual effects is an interesting and promising target for chronic pain therapy.展开更多
The management of patients with concomitant chronic pain (CP) and Major Depressive Disorder (MDD) remains challenging for clinicians. Current chronic pharmacologic management is often unsuccessful, or has intolerable ...The management of patients with concomitant chronic pain (CP) and Major Depressive Disorder (MDD) remains challenging for clinicians. Current chronic pharmacologic management is often unsuccessful, or has intolerable side effects to the patients. While not restricted to patients with chronic pain, these patients are often diagnosed with depression, presenting with symptoms such as poor mood, anhedonia, and altered cognitive processes. It is estimated that a substantial proportion of treated patients do not derive a substantive benefit from traditional pharmacological treatments for depression. The present study involved a retrospective review of cases, exploring the patient-reported satisfaction with and tolerability of a novel use of virtual reality (VR), coined KVR, as an adjunct to intravenous ketamine infusion therapies. Specifically, the ketamine-virtual reality protocol was employed as a potential adjunctive intervention for patients suffering from chronic pain and depression. Visual Analog Scores (VAS) associated with pain were significantly lower on the third than on the first assessment day. Montgomery-?sberg Depression Rating Scale (MADRS) scores improved following infusion and across days (i.e., sessions). Lastly, 2/3 of patients preferred the use of VR with their ketamine infusion. The results are considered in terms of implementing prospective studies to examine whether the combination therapies have a synergistic benefit and the nature and magnitude of clinically meaningful treatment effects, if any.展开更多
Chronic pain is a multifaceted debilitating experience often associated with significant physical and emotional burden. Low dose naltrexone (LDN) has gained attention in recent years for its potential utility in the m...Chronic pain is a multifaceted debilitating experience often associated with significant physical and emotional burden. Low dose naltrexone (LDN) has gained attention in recent years for its potential utility in the management of fibromyalgia, irritable bowel syndrome, multiple sclerosis, and painful diabetic neuropathy. LDN’s analgesic effects have been associated with its ability to increase the production of endorphins while reducing the production of tumor necrosis factor-alpha, interleukin-6, reactive oxygen species and nitric oxide. This meta-analysis aims to systematically review and synthesize the available evidence on efficacy of LDN as an analgesic in pain syndromes, with a focus on chronic (neuro) inflammatory diseases. The goal is to provide clinicians with a more comprehensive estimate of the effectiveness of LDN as a non-opioid option for managing chronic pain and guide future research in the area. Thirteen randomized control trials, published from 1990 to 2022, were selected for the analysis that satisfied inclusion criteria. The overall effects in these studies were calculated using the standardized mean difference (SMD) between the LDN and placebo groups. We found an overall SMD of -10.77 (95% CI: -13.96 to -7.58) with a p-value of 0.002. This indicated that the LDN group experienced a statistically significant reduction in pain compared to placebo. This meta-analysis provides evidence for the potential efficacy of low dose naltrexone in reducing pain and enhancing analgesia in various pain syndromes. LDN may be a useful treatment option for patients suffering from chronic pain, particularly with fibromyalgia, multiple sclerosis, or diabetic neuropathy. However, further research is needed to confirm the efficacy and safety of low dose naltrexone for chronic pain conditions, especially with larger sample sizes, standardized dosing regimens and treatment durations.展开更多
Background:The present investigation tested the efficacy of the Tennant Biomodulator,a novel pain management intervention that uses biofeedback-modulated electrical stimulation,to reduce chronic pain and its psychosoc...Background:The present investigation tested the efficacy of the Tennant Biomodulator,a novel pain management intervention that uses biofeedback-modulated electrical stimulation,to reduce chronic pain and its psychosocial sequelae in a sample of current and former military service members.The Tennant Biomodulator used on its most basic setting was compared to two commonly used,non-pharmacological pain treatments—traditional Chinese acupuncture and transcutaneous electrical nerve stimulation(TENS)—in a comparative efficacy,randomized,open-label trial.Methods:Participants included 100 active duty and retired service men and women with chronic pain undergoing treatment at the Brooke Army Medical Center in Texas,USA,randomly assigned to receive six,weekly sessions of either Tennant Biomodulator treatment,traditional Chinese acupuncture,or TENS,in addition to usual care.Recruitment was conducted between May 2010 to September 2013.Outcome measures were collected at intake,before and after each treatment session,and at a 1-month follow-up.Intent-to-treat analyses were used throughout,with mixed models used to investigate main effects of group,time,and group×time interactions with consideration given to quadratic effects.Outcomes measured included ratings of chronic pain,pain-related functional disability,and symptoms of post-traumatic stress disorder(PTSD)and depression.Results:On average,regardless of their treatment group,participants exhibited a 16%reduction in pain measured by the Brooke Army Medical Center’s Clinic Pain Log[F(1,335)=55.7,P<0.0001]and an 11%reduction in pain-related disability measured by the Million Visual Analog Scale[MVAS:F(1,84)=28.3,P<0.0001]from baseline to the end of treatment,but no one treatment performed better than the other,and the reductions in pain and pain-related disability were largely lost by 1-month follow-up.Symptoms of PTSD and depression did not change significantly as a function of time or group.Conclusions:Findings build on previous work suggesting that traditional Chinese acupuncture and TENS can reduce pain and its functional sequelae without risks associated with pharmacological pain management.The Tennant Biomodulator used on its most basic setting performs as well as these other interventions.Based on the present findings,large,randomized controlled trials on the Tennant Biomodulator are indicated.Future work should test this device using its full range of settings for pain-related psychological health.Trial registration:Clincialtrials.gov(NCT01752010);registered December 14,2012.展开更多
Objective: The purpose of this qualitative study was to describe the experiences of pain acceptance in Chinese cancer patients with chronic pain.Methods: Twelve hospitalized cancer patients with chronic pain participa...Objective: The purpose of this qualitative study was to describe the experiences of pain acceptance in Chinese cancer patients with chronic pain.Methods: Twelve hospitalized cancer patients with chronic pain participated in this qualitative descriptive study from August to November 2017.In-person semi-structured interviews were conducted,recorded,transcribed,and analyzed using Colaizzi's seven-step method.Results: The following four main themes and 15 subthemes emerged.Theme 1 (adaptation): pain is overwhelming and pain relief is a top priority,avoidance of pain-inducing factors,and resignation;theme 2 (emotional reactions to pain): feeling misunderstood,hopelessness,frustration,irritability,and concern for loved ones;theme 3 (functional limitations): daily life activities,social communication,and work;theme 4 (coping strategies): pharmacological therapies,behavioral strategies,social support strategies,and spiritual strategies.Conclusions: This study provides a description of cancer patients' experiences related to the need for pain acceptance.These findings provide insight into the essential role of pain acceptance and underline the need to apply acceptance-based cognitive behavioral interventions as adjunctive non-pharmacological alternatives for chronic cancer pain.展开更多
Objective:To review trials on mindfulness intervention for chronic pain in primary care to clarify the evidence base and establish whether mindfulness is an important intervention for relieving pain and improving psyc...Objective:To review trials on mindfulness intervention for chronic pain in primary care to clarify the evidence base and establish whether mindfulness is an important intervention for relieving pain and improving psychological comorbidity.Methods:We performed a literature search using PubMed,the Cochrane Database,EBSCOhost,Elsevier,Wiley,Springer,and the references of retrieved articles.We included articles written in English and that were published up to January 2012.We found 428 empirical studies,but only eight were included as randomized controlled trials of mindfulness intervention for chronic pain in our meta-analysis.After extracting and synthesizing data from these eight trials,we analyzed the data extracted and synthesized from these eight trials.Results:Compared with control intervention,mindfulness intervention had no specific effect on reducing pain intensity(weighted mean difference 3.24,95%confidence interval[CI]:8.92 to 2.45).Mindfulness intervention led to greater improvement in psychological comorbidity with chronic pain,such as depression(weighted mean difference3.91,95%CI5.94 to2.32)and trait anxiety(weighted mean difference4.07,95%CI4.48 to3.65).Conclusion:There is insufficient evidence that mindfulness intervention relieves pain intensity.However,it improves depression and trait anxiety in patients with chronic pain.Further research in larger,properly powered,and better-designed studies is warranted.展开更多
BACKGROUND Vitamin D deficiency is common in patients with chronic pain and healthy people,but the difference between the two has not been reported;thus,whether there is a relationship between vitamin D deficiency and...BACKGROUND Vitamin D deficiency is common in patients with chronic pain and healthy people,but the difference between the two has not been reported;thus,whether there is a relationship between vitamin D deficiency and chronic pain remains to be confirmed.Osteoporosis is a common disease in chronic pain disorders.Understanding the relationship between vitamin D and osteoporosis will provide a basis for the rational supplementation of vitamin D to prevent osteoporosis,and to understand the risk factors of bone mass change to provide a new treatment plan for early prevention of osteoporosis.AIM To determine 25 hydroxy vitamin D(25OHD)level in patients with chronic pain to clarify its clinical significance.The relationship between vitamin D and bone mineral density(BMD)and the risk factors for bone mass change were also evaluated.METHODS In this study,184 patients with chronic pain were included in the study group,and 104 healthy individuals who underwent routine health checkups during the same period were included in the control group.25OHD level was detected in both groups by enzyme-linked immunosorbent assay.According to the BMD test results,the patients in the study group were further classified into three subgroups:Normal BMD group,reduced BMD group,and osteoporosis group.Age,sex,ethnicity,living altitude,body mass index,25OHD level,parathyroid hormone(PTH),calcium(Ca)and phosphorus levels were analyzed statistically in both groups.RESULTS The vitamin D level in the study group was lower than that in the control group at 53.8%vs 57.7%,with no significant difference between the two groups.The proportion of patients with severe vitamin D deficiency in the study group was higher than that in the control group.The mean age was greater in the osteoporosis subgroup,and the youngest in the normal BMD subgroup.Vitamin D level in the osteoporosis subgroup was lower than that in the other two subgroups,and was not specific for the diagnosis of bone mass reduction and osteoporosis.The above results were analyzed statistically and showed significant differences(P<0.05).There was a positive correlation between age and BMD in patients with chronic pain(R=0.567,P<0.001).Age,PTH and Ca were risk factors for bone mass reduction,while age,ethnicity and altitude were risk factors for osteoporosis.CONCLUSION Vitamin D deficiency is a common phenomenon in patients with chronic pain,and severe vitamin D deficiency is not uncommon.Vitamin D level is not a risk factor for bone mass reduction and osteoporosis.Bone mass reduction is correlated with age,PTH and Ca,while osteoporosis is correlated with age,ethnicity and altitude.展开更多
The aim of this study was to evaluate the prevalence of chronic pain (CP) and the relationship between CP, especially headache adjusted for CP at other sites, and health-related quality of life (HRQoL) in middle-aged ...The aim of this study was to evaluate the prevalence of chronic pain (CP) and the relationship between CP, especially headache adjusted for CP at other sites, and health-related quality of life (HRQoL) in middle-aged Japanese residents. We examined the prevalence of CP (defined as pain persisting for 3 months or more) and HRQoL (SF-36) in 1117 middle-aged residents of Japan. We assessed the eight dimensions of health status and the 3 component SF-36 summary score to evaluate HRQoL. The prevalence of CP was 15.3% among men and 15.1% among women. Multiple linear regression analysis demonstrated that lumbar pain (p β = -0.132), knee pain (p β = -0.115), foot pain (p = 0.042, β = -0.065), and age (p β = -0.154) were independently correlated with a lower physical component score (PCS). Older age (ppβ = -0.096), knee pain (p β = -0.109), upper limb pain (p β = -0.098), and lumbar pain (p = 0.022, β = -0.077) all showed a significant negative correlation with MCS. The presence of chronic headache (p = 0.011, β = -0.082) was the only factor significantly correlated with a lower role component score (RCS). We identified a negative correlation between chronic headache and RCS, unlike the relation between musculoskeletal pain and PCS or MCS, suggesting that RCS was an independently influenced by CP differently from PCS or MCS in Japanese residents.展开更多
This paper addresses the topic of an interdisciplinary approach of chronic pain management from a biopsychosocial perspective. The first section provides an introduction to the definitions and theories of chronic pain...This paper addresses the topic of an interdisciplinary approach of chronic pain management from a biopsychosocial perspective. The first section provides an introduction to the definitions and theories of chronic pain and the various contributing factors (psychological, interpersonal/environmental and social support, and vocational). The second section presents the role of various health care professions (medical doctors, nurses, physical therapists, occupational therapists, psychologists and rehabilitation counselors) and the evidence of their treatment effectiveness. The third section discusses the concept of an interdisciplinary pain rehabilitation program (IPRP) and its evidence to support its effectiveness. Finally, the clinical implications of rehabilitation counseling and psychology as part of the inter-disciplinary program in treating individuals with chronic pain will be highlighted.展开更多
Pain and depression are the most common neural responses to many harmful or harmful stimuli.The two are risk factors for each other.The comorbid relationship between pain and depression makes clinical treatment diffic...Pain and depression are the most common neural responses to many harmful or harmful stimuli.The two are risk factors for each other.The comorbid relationship between pain and depression makes clinical treatment difficult.Seeking an analgesic and antidepressant is an urgent goal of clinical management of pain and depression.Melatonin(N-acetyl-5-methoxytryptamine)secreted by the pineal gland has multiple functions,including anti-inflammatory,antioxidant,immunomodulatory,sedative and analgesic.The effectiveness,safety,and basic non-toxic side effects of melatonin as an analgesic and antidepressant have been demonstrated in various pain animal models,which makes melatonin different in pathological conditions and during surgery.It has been used clinically in patients.Melatonin-mediated analgesic and antidepressant effects may involve inflammatory factors,astrocytes,protein kinase C(PKC)/N-methyl-D-aspartate(NMDA)pathway.However,there are few reports about the mechanism of melatonin in pain syndrome and depression in China.Therefore,this article summarizes the analgesic and antidepressant mechanism of melatonin by consulting domestic and foreign literatures.Provide theoretical basis for clinical treatment of related diseases.展开更多
Chronic pain is one of the major complaints from patients seen in all acupuncture clinics.The most common principle to treat pain with acupuncture is to activate channels to relieve pain;however,little attention has b...Chronic pain is one of the major complaints from patients seen in all acupuncture clinics.The most common principle to treat pain with acupuncture is to activate channels to relieve pain;however,little attention has been paid to treating the patient’s shen when treating their pain.This article is an introduction to the incorporation of the treatment of shen when treating chronic pain with acupuncture.The discussion of the shen and its treatments in this article are based on the review and study of the theories and principles in the ancient classics of traditional Chinese medicine.Shen is the interaction between yin and yang.Shen is the governor of life;it controls all physical and mental activities.Shen enables us to feel pain.The disorders of shen in pain sufferers can negatively affect how they feel or recognize pain,how they response to pain and how they report their pain level.We should pay more attention to the treatment of patient’s shen during the entire treatment course of chronic pain.Guarding shen is the key to acupuncture efficacy;the essential principles are harmonizing yin and yang by needling techniques and regulating hun and po at the needling sites.展开更多
Objective:The aim of this scoping review was to provide evidence for health practitioners to improve patient education practice for chronic pain management.Methods:A scoping review was guided by Arksey and O’Malley’...Objective:The aim of this scoping review was to provide evidence for health practitioners to improve patient education practice for chronic pain management.Methods:A scoping review was guided by Arksey and O’Malley’s(2005)1 five-stage framework,investigated contemporary patient education programs(2007–2018)for chronic pain management in education content,formats of delivery,and tools used for evaluation.Content analysis and description were used for the outcome report.Results:Seven quantitative studies were included.Education content consisted of General information,Cognitive behavior therapy(CBT),Self-management,and Pain neurophysiology(PN).Education delivery formats varied from workbook to workbook,face-toface,online,when given for a group or individual or in a combined way.In total,19 tools were reported for the evaluation of the education programs.Conclusions:There is a variety in the education content and the delivery formats.The majority of programs showed effectiveness in patients’chronic pain management based on their selected evaluation tools.This review showed that patient education programs can be useful in chronic pain management.The effectiveness of patient education programs focuses on the improved patients’physical function and quality of life rather than the cessation of pain only.展开更多
BACKGROUND The literature suggests that there is a high degree of co-occurrence between chronic pain and posttraumatic stress disorder(PTSD). An association has been found between PTSD and substance abuse. PTSD is a s...BACKGROUND The literature suggests that there is a high degree of co-occurrence between chronic pain and posttraumatic stress disorder(PTSD). An association has been found between PTSD and substance abuse. PTSD is a severe disorder that should be taken into account when opioids are prescribed. It has been found that the prevalence of opioid use disorder(OUD) in chronic pain patients is higher among those with PTSD than those without this disorder.AIM To perform a systematic review on the association between PTSD, chronic noncancer pain(CNCP), and opioid intake(i.e., prescription, misuse, and abuse).METHODS We conducted a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The Patient, Intervention,Comparator, and Outcomes(PICOS) criteria were formulated a priori in the protocol of the systematic review. A search was conducted of the PROSPERO database. In March 2019, searches were also conducted of 5 other databases:Pub Med, MEDLINE, Psyc INFO, Web of Science, and PILOTS. The Scottish Intercollegiate Guidelines Network checklist for cohort studies was used to assess the selected studies for their methodological quality and risk of bias. Each study was evaluated according to its internal validity, participant sampling,confounding variables, and the statistical analysis.RESULTS A total of 151 potentially eligible studies were identified of which 17 were retained for analysis. Only 10 met the selection criteria. All the studies were published between 2008 and 2018 and were conducted in the United States. The eligible studies included a total of 1622785 unique participants. Of these, 196516 had comorbid CNCP and PTSD and were consuming opiates. The participants had a cross-study mean age of 35.2 years. The majority of participants were men(81.6%). The most common chronic pain condition was musculoskeletal pain:back pain(47.14% across studies;range: 16%-60.6%), arthritis and joint pain(31.1%;range: 18%-67.5%), and neck pain(28.7%;range: 3.6%-63%). In total,42.4% of the participants across studies had a diagnosis of PTSD(range: 4.7%-95%). In relation to opioid intake, we identified 2 different outcomes: opioid prescription and OUD. All the studies reported evidence of a greater prevalence of PTSD in CNCP patients who were receiving prescribed opioids and that PTSD was associated with OUD in CNCP patients.CONCLUSION Opioid analgesic prescription as the treatment of choice for CNCP patients should include screening for baseline PTSD to ensure that these drugs are safely consumed.展开更多
In this study, we examined extensive narratives prepared by participants who attended a chronic pain management programme where therapeutic writing was included. The aim was to explore how narrators experience the con...In this study, we examined extensive narratives prepared by participants who attended a chronic pain management programme where therapeutic writing was included. The aim was to explore how narrators experience the contexts in which their lives unfold following a cognitive behavioural programme. The analysis was based on a three-sphere model for context analysis, which referred to the contexts in which the narrators located their life stories: their immediate inter-subjective relationships, the collective social field, and broad cultural meaning. We identified important change processes related to adaptation. Our examination of the experience of therapeutic writing clearly indicated that therapeutic writing is helpful. We suggest that obtaining a better understanding of living with chronic pain through storytelling as part of therapeutic writing and using a three-sphere model for context analysis could improve understanding and approaches to nursing. Health carers should organize care around the experience of illness and its inter-subjective, social, and cultural consequences, which may provide a deeper understanding of identity and the core themes embedded in life stories.展开更多
Pain is a common event in many scenarios involving healthcare, from birth to death, in the hospital or outside of it. The overall purpose of this work was to critically review articles on types of pain and options emp...Pain is a common event in many scenarios involving healthcare, from birth to death, in the hospital or outside of it. The overall purpose of this work was to critically review articles on types of pain and options employed in managing pain. Some electronic sources like google scholar, Ovid MEDLINE, PsychINFO, Embase were used to source for information. The articles were reviewed according to the various themes of the topic. From the different sources pain is categorized as acute or chronic with physical, psychological and social characteristics. Effective management of pain utilizes both pharmacologic and non-pharmacologic therapy. Pharmacological therapy employs non-opioids medications. Prolonged or unnecessary use of opioids causes some harmful side effects to the patient. Non-pharmacologic therapy plays a significant role and should be included in the multidisciplinary treatment plan. Nurses are members of the healthcare team who spend most of their time with patients as such they must work in collaboration with other healthcare professionals to facilitate patient’s recovery from pain. Healthcare professionals should also make use of internationally recognized guidelines during practice.展开更多
Objective: To analyze the intensity of chronic pain and pharmacotherapy in chronic renal patients on hemodialysis. Method: This is a cross-sectional, prospective study conducted in a Service of Substitute Renal Therap...Objective: To analyze the intensity of chronic pain and pharmacotherapy in chronic renal patients on hemodialysis. Method: This is a cross-sectional, prospective study conducted in a Service of Substitute Renal Therapy in the South region of Brazil. Seventy adult patients with chronic renal disease, who were undergoing hemodialysis treatment in the first half of 2015, participated in the study. We used the Graduated Scale for Chronic Pain. The data were analyzed with the Statistical Package for Social Sciences software version 18.0. The study was approved under N°. CAAE: 20138913.4.0000.0118. Results: Fifty-one (72%) patients reported some forms of pain in the last six months, 17 (24%) reported severely limiting pain, high interference and persistence. Painkillers were most widely used therapy for pain management, in 19 patients (27%). Conclusion: Chronic pain was reported in different degrees of intensity, with severely limiting character, high interference, and persistence. Painkillers were the most widely used pharmacological class to control it.展开更多
Objective To screen the key genes of chronic pain and provide a reference for the treatment of chronic pain.Methods We performed comprehensive bioinformatics analysis by screening chronic primary pain-related datasets...Objective To screen the key genes of chronic pain and provide a reference for the treatment of chronic pain.Methods We performed comprehensive bioinformatics analysis by screening chronic primary pain-related datasets to obtain differentially expressed genes(DEGs)and then imported DEGs into the DAVID database for Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis.Gene Set Enrichment Analysis(GESA)analysis was done by GSEA_4.1.0 software.At the same time,we imported the intersecting genes into the STRING database and processed them by Cytoscape_3.8.1 software to obtain the protein-protein interaction(PPI)network and the central gene.Results As a result,a total of 54 DEGs were screened,including 47 up-regulated genes,1 down-regulated gene,and 6 genes that were expressed differently in different datasets.23 GO terms and 8 KEGG pathways were enriched by DAVID.PPI network analysis found that SPI1,STAT3,TNFRSF1B,PTGS2,and CXCL1 genes interacted more strongly with other genes,and were predicted to be key genes in chronic primary pain.Conclusion Our results suggested that 5 DEGs,STAT3,SPI1,TNFRSF1B,PTGS2,and CXCL1,have the potential to be used as prognostic and predictive markers for the clinical management of patients with this disease.展开更多
A reduction in gray matter volume is common in patients with chronic back pain,and different types of pain are associated with gray matter abnormalities in distinct brain regions.To examine differences in brain morpho...A reduction in gray matter volume is common in patients with chronic back pain,and different types of pain are associated with gray matter abnormalities in distinct brain regions.To examine differences in brain morphology in patients with low back pain or neck and upper back pain,we investigated changes in gray matter volume in chronic back pain patients having different sites of pain using voxel-based morphometry.A reduction in cortical gray matter volume was found primarily in the left postcentral gyrus and in the left precuneus and bilateral cuneal cortex of patients with low back pain.In these patients,there was an increase in subcortical gray matter volume in the bilateral putamen and accumbens,right pallidum,right caudate nucleus,and left amygdala.In upper back pain patients,reduced cortical gray matter volume was found in the left precentral and left postcentral cortices.Our findings suggest that regional gray matter volume abnormalities in low back pain patients are more extensive than in upper back pain patients.Subcortical gray matter volume increases are found only in patients with low back pain.展开更多
基金supported by the National Natural Science Foundation of China,No.82173796(to CX)the Research Project of Zhejiang Chinese Medical University,No.2022JKJNTZ13(to XQ).
文摘Satellite glial cells are unique glial cells that surround the cell body of primary sensory neurons.An increasing body of evidence suggests that in the presence of inflammation and nerve damage,a significant number of satellite glial cells become activated,thus triggering a series of functional changes.This suggests that satellite glial cells are closely related to the occurrence of chronic pain.In this review,we first summarize the morphological structure,molecular markers,and physiological functions of satellite glial cells.Then,we clarify the multiple key roles of satellite glial cells in chronic pain,including gap junction hemichannel Cx43,membrane channel Pannexin1,K channel subunit 4.1,ATP,purinergic P2 receptors,and a series of additional factors and their receptors,including tumor necrosis factor,glutamate,endothelin,and bradykinin.Finally,we propose that future research should focus on the specific sorting of satellite glial cells,and identify genomic differences between physiological and pathological conditions.This review provides an important perspective for clarifying mechanisms underlying the peripheral regulation of chronic pain and will facilitate the formulation of new treatment plans for chronic pain.
文摘Background: Chronic pain is a major public health issue. It is a complex condition comprising biological, social and psychological elements, which can be challenging to manage. Forgiveness is a recognised effective intervention in various health conditions. Research has shown promising results using forgiveness as an intervention in the management of pain. This study aims to examine the relationship between forgiveness and other variables in patients suffering from chronic pain in the setting of a chronic pain clinic. Methods: Institutional ethical approval was granted for this study. Patients attending a chronic pain clinic for the first time were invited to complete a questionnaire comprising a brief socio-demographic survey and questionnaires including the Heartland Forgiveness Scale, Hospital Anxiety and Depression Scale, Pain and Anxiety Symptoms Scale and Perceived Injustice. Results: 104 adult patients were included. The mean age was 59 years. Back pain was the most common chronic pain presentation. The Heartland Forgiveness Scale (HFS) was found to have a good internal consistency among the Irish population. This study found that 55% of patients attending the pain clinic were not forgiving. Negative correlations were identified between forgiveness and pain, and forgiveness and injustice. Conclusion: The majority of patients attending a chronic pain clinic were not forgiving as measured on the HFS. There was a negative correlation between forgiveness and pain. The results have shown that forgiveness could be beneficial as a therapeutic intervention among patients attending a chronic pain clinic.
基金supported by the National Natural Science Foundation of China,Nos. 82071556 (to WM), 81873793 (to WM), 82001198 (to YQZ), 82101310 (to DQL)the National Key Research and Development Program of China,No. 2020YFC2005300 (to WM)。
文摘Nitric oxide(NO)/cyclic guanosine 3′,5′-monophosphate(cGMP) signaling has been shown to act as a mediator involved in pain transmission and processing. In this review, we summarize and discuss the mechanisms of the NO/cGMP signaling pathway involved in chronic pain, including neuropathic pain, bone cancer pain, inflammatory pain, and morphine tolerance. The main process in the NO/cGMP signaling pathway in cells involves NO activating soluble guanylate cyclase, which leads to subsequent production of cGMP. cGMP then activates cGMP-dependent protein kinase(PKG), resulting in the activation of multiple targets such as the opening of ATP-sensitive K+ channels. The activation of NO/cGMP signaling in the spinal cord evidently induces upregulation of downstream molecules, as well as reactive astrogliosis and microglial polarization which participate in the process of chronic pain. In dorsal root ganglion neurons, natriuretic peptide binds to particulate guanylyl cyclase, generating and further activating the cGMP/PKG pathway, and it also contributes to the development of chronic pain. Upregulation of multiple receptors is involved in activation of the NO/cGMP signaling pathway in various pain models. Notably the NO/cGMP signaling pathway induces expression of downstream effectors, exerting both algesic and analgesic effects in neuropathic pain and inflammatory pain. These findings suggest that activation of NO/cGMP signaling plays a constituent role in the development of chronic pain, and this signaling pathway with dual effects is an interesting and promising target for chronic pain therapy.
文摘The management of patients with concomitant chronic pain (CP) and Major Depressive Disorder (MDD) remains challenging for clinicians. Current chronic pharmacologic management is often unsuccessful, or has intolerable side effects to the patients. While not restricted to patients with chronic pain, these patients are often diagnosed with depression, presenting with symptoms such as poor mood, anhedonia, and altered cognitive processes. It is estimated that a substantial proportion of treated patients do not derive a substantive benefit from traditional pharmacological treatments for depression. The present study involved a retrospective review of cases, exploring the patient-reported satisfaction with and tolerability of a novel use of virtual reality (VR), coined KVR, as an adjunct to intravenous ketamine infusion therapies. Specifically, the ketamine-virtual reality protocol was employed as a potential adjunctive intervention for patients suffering from chronic pain and depression. Visual Analog Scores (VAS) associated with pain were significantly lower on the third than on the first assessment day. Montgomery-?sberg Depression Rating Scale (MADRS) scores improved following infusion and across days (i.e., sessions). Lastly, 2/3 of patients preferred the use of VR with their ketamine infusion. The results are considered in terms of implementing prospective studies to examine whether the combination therapies have a synergistic benefit and the nature and magnitude of clinically meaningful treatment effects, if any.
文摘Chronic pain is a multifaceted debilitating experience often associated with significant physical and emotional burden. Low dose naltrexone (LDN) has gained attention in recent years for its potential utility in the management of fibromyalgia, irritable bowel syndrome, multiple sclerosis, and painful diabetic neuropathy. LDN’s analgesic effects have been associated with its ability to increase the production of endorphins while reducing the production of tumor necrosis factor-alpha, interleukin-6, reactive oxygen species and nitric oxide. This meta-analysis aims to systematically review and synthesize the available evidence on efficacy of LDN as an analgesic in pain syndromes, with a focus on chronic (neuro) inflammatory diseases. The goal is to provide clinicians with a more comprehensive estimate of the effectiveness of LDN as a non-opioid option for managing chronic pain and guide future research in the area. Thirteen randomized control trials, published from 1990 to 2022, were selected for the analysis that satisfied inclusion criteria. The overall effects in these studies were calculated using the standardized mean difference (SMD) between the LDN and placebo groups. We found an overall SMD of -10.77 (95% CI: -13.96 to -7.58) with a p-value of 0.002. This indicated that the LDN group experienced a statistically significant reduction in pain compared to placebo. This meta-analysis provides evidence for the potential efficacy of low dose naltrexone in reducing pain and enhancing analgesia in various pain syndromes. LDN may be a useful treatment option for patients suffering from chronic pain, particularly with fibromyalgia, multiple sclerosis, or diabetic neuropathy. However, further research is needed to confirm the efficacy and safety of low dose naltrexone for chronic pain conditions, especially with larger sample sizes, standardized dosing regimens and treatment durations.
基金funding source was grant#W81XWH-06-2-0279 from the United States Army Medical Research Acquisition Activity through the Telemedicine and Advanced Technology Research Centerwhich was provided to the Samueli Institutefunding was provided as a gift to the Samueli Institute by an anonymous donor with no conflicts of interest to declare。
文摘Background:The present investigation tested the efficacy of the Tennant Biomodulator,a novel pain management intervention that uses biofeedback-modulated electrical stimulation,to reduce chronic pain and its psychosocial sequelae in a sample of current and former military service members.The Tennant Biomodulator used on its most basic setting was compared to two commonly used,non-pharmacological pain treatments—traditional Chinese acupuncture and transcutaneous electrical nerve stimulation(TENS)—in a comparative efficacy,randomized,open-label trial.Methods:Participants included 100 active duty and retired service men and women with chronic pain undergoing treatment at the Brooke Army Medical Center in Texas,USA,randomly assigned to receive six,weekly sessions of either Tennant Biomodulator treatment,traditional Chinese acupuncture,or TENS,in addition to usual care.Recruitment was conducted between May 2010 to September 2013.Outcome measures were collected at intake,before and after each treatment session,and at a 1-month follow-up.Intent-to-treat analyses were used throughout,with mixed models used to investigate main effects of group,time,and group×time interactions with consideration given to quadratic effects.Outcomes measured included ratings of chronic pain,pain-related functional disability,and symptoms of post-traumatic stress disorder(PTSD)and depression.Results:On average,regardless of their treatment group,participants exhibited a 16%reduction in pain measured by the Brooke Army Medical Center’s Clinic Pain Log[F(1,335)=55.7,P<0.0001]and an 11%reduction in pain-related disability measured by the Million Visual Analog Scale[MVAS:F(1,84)=28.3,P<0.0001]from baseline to the end of treatment,but no one treatment performed better than the other,and the reductions in pain and pain-related disability were largely lost by 1-month follow-up.Symptoms of PTSD and depression did not change significantly as a function of time or group.Conclusions:Findings build on previous work suggesting that traditional Chinese acupuncture and TENS can reduce pain and its functional sequelae without risks associated with pharmacological pain management.The Tennant Biomodulator used on its most basic setting performs as well as these other interventions.Based on the present findings,large,randomized controlled trials on the Tennant Biomodulator are indicated.Future work should test this device using its full range of settings for pain-related psychological health.Trial registration:Clincialtrials.gov(NCT01752010);registered December 14,2012.
基金This study was supported by the Hunan Provincial Natural Science Fund,China,grant number 2018JJ6110
文摘Objective: The purpose of this qualitative study was to describe the experiences of pain acceptance in Chinese cancer patients with chronic pain.Methods: Twelve hospitalized cancer patients with chronic pain participated in this qualitative descriptive study from August to November 2017.In-person semi-structured interviews were conducted,recorded,transcribed,and analyzed using Colaizzi's seven-step method.Results: The following four main themes and 15 subthemes emerged.Theme 1 (adaptation): pain is overwhelming and pain relief is a top priority,avoidance of pain-inducing factors,and resignation;theme 2 (emotional reactions to pain): feeling misunderstood,hopelessness,frustration,irritability,and concern for loved ones;theme 3 (functional limitations): daily life activities,social communication,and work;theme 4 (coping strategies): pharmacological therapies,behavioral strategies,social support strategies,and spiritual strategies.Conclusions: This study provides a description of cancer patients' experiences related to the need for pain acceptance.These findings provide insight into the essential role of pain acceptance and underline the need to apply acceptance-based cognitive behavioral interventions as adjunctive non-pharmacological alternatives for chronic cancer pain.
基金supported by Nantong Science and Technology Information Bureau(HS2012046).
文摘Objective:To review trials on mindfulness intervention for chronic pain in primary care to clarify the evidence base and establish whether mindfulness is an important intervention for relieving pain and improving psychological comorbidity.Methods:We performed a literature search using PubMed,the Cochrane Database,EBSCOhost,Elsevier,Wiley,Springer,and the references of retrieved articles.We included articles written in English and that were published up to January 2012.We found 428 empirical studies,but only eight were included as randomized controlled trials of mindfulness intervention for chronic pain in our meta-analysis.After extracting and synthesizing data from these eight trials,we analyzed the data extracted and synthesized from these eight trials.Results:Compared with control intervention,mindfulness intervention had no specific effect on reducing pain intensity(weighted mean difference 3.24,95%confidence interval[CI]:8.92 to 2.45).Mindfulness intervention led to greater improvement in psychological comorbidity with chronic pain,such as depression(weighted mean difference3.91,95%CI5.94 to2.32)and trait anxiety(weighted mean difference4.07,95%CI4.48 to3.65).Conclusion:There is insufficient evidence that mindfulness intervention relieves pain intensity.However,it improves depression and trait anxiety in patients with chronic pain.Further research in larger,properly powered,and better-designed studies is warranted.
基金Supported by the 2016 Guidance Project of Qinghai Provincial Health and Family Planning Commission,No.2016-wjzdx-14.
文摘BACKGROUND Vitamin D deficiency is common in patients with chronic pain and healthy people,but the difference between the two has not been reported;thus,whether there is a relationship between vitamin D deficiency and chronic pain remains to be confirmed.Osteoporosis is a common disease in chronic pain disorders.Understanding the relationship between vitamin D and osteoporosis will provide a basis for the rational supplementation of vitamin D to prevent osteoporosis,and to understand the risk factors of bone mass change to provide a new treatment plan for early prevention of osteoporosis.AIM To determine 25 hydroxy vitamin D(25OHD)level in patients with chronic pain to clarify its clinical significance.The relationship between vitamin D and bone mineral density(BMD)and the risk factors for bone mass change were also evaluated.METHODS In this study,184 patients with chronic pain were included in the study group,and 104 healthy individuals who underwent routine health checkups during the same period were included in the control group.25OHD level was detected in both groups by enzyme-linked immunosorbent assay.According to the BMD test results,the patients in the study group were further classified into three subgroups:Normal BMD group,reduced BMD group,and osteoporosis group.Age,sex,ethnicity,living altitude,body mass index,25OHD level,parathyroid hormone(PTH),calcium(Ca)and phosphorus levels were analyzed statistically in both groups.RESULTS The vitamin D level in the study group was lower than that in the control group at 53.8%vs 57.7%,with no significant difference between the two groups.The proportion of patients with severe vitamin D deficiency in the study group was higher than that in the control group.The mean age was greater in the osteoporosis subgroup,and the youngest in the normal BMD subgroup.Vitamin D level in the osteoporosis subgroup was lower than that in the other two subgroups,and was not specific for the diagnosis of bone mass reduction and osteoporosis.The above results were analyzed statistically and showed significant differences(P<0.05).There was a positive correlation between age and BMD in patients with chronic pain(R=0.567,P<0.001).Age,PTH and Ca were risk factors for bone mass reduction,while age,ethnicity and altitude were risk factors for osteoporosis.CONCLUSION Vitamin D deficiency is a common phenomenon in patients with chronic pain,and severe vitamin D deficiency is not uncommon.Vitamin D level is not a risk factor for bone mass reduction and osteoporosis.Bone mass reduction is correlated with age,PTH and Ca,while osteoporosis is correlated with age,ethnicity and altitude.
文摘The aim of this study was to evaluate the prevalence of chronic pain (CP) and the relationship between CP, especially headache adjusted for CP at other sites, and health-related quality of life (HRQoL) in middle-aged Japanese residents. We examined the prevalence of CP (defined as pain persisting for 3 months or more) and HRQoL (SF-36) in 1117 middle-aged residents of Japan. We assessed the eight dimensions of health status and the 3 component SF-36 summary score to evaluate HRQoL. The prevalence of CP was 15.3% among men and 15.1% among women. Multiple linear regression analysis demonstrated that lumbar pain (p β = -0.132), knee pain (p β = -0.115), foot pain (p = 0.042, β = -0.065), and age (p β = -0.154) were independently correlated with a lower physical component score (PCS). Older age (ppβ = -0.096), knee pain (p β = -0.109), upper limb pain (p β = -0.098), and lumbar pain (p = 0.022, β = -0.077) all showed a significant negative correlation with MCS. The presence of chronic headache (p = 0.011, β = -0.082) was the only factor significantly correlated with a lower role component score (RCS). We identified a negative correlation between chronic headache and RCS, unlike the relation between musculoskeletal pain and PCS or MCS, suggesting that RCS was an independently influenced by CP differently from PCS or MCS in Japanese residents.
文摘This paper addresses the topic of an interdisciplinary approach of chronic pain management from a biopsychosocial perspective. The first section provides an introduction to the definitions and theories of chronic pain and the various contributing factors (psychological, interpersonal/environmental and social support, and vocational). The second section presents the role of various health care professions (medical doctors, nurses, physical therapists, occupational therapists, psychologists and rehabilitation counselors) and the evidence of their treatment effectiveness. The third section discusses the concept of an interdisciplinary pain rehabilitation program (IPRP) and its evidence to support its effectiveness. Finally, the clinical implications of rehabilitation counseling and psychology as part of the inter-disciplinary program in treating individuals with chronic pain will be highlighted.
基金General project of scientific research plan of PLA logistics(No.CWH17J009)PLA training program of medical science and technology for the Youth(No.19QNP047)+2 种基金Gansu provincial youth foundation of science and technology(No.1606RJYA300)Gansu provincial planning project for scientific research of health industry(No.GSWSKY2018-21)Lanzhou talent innovation and entrepreneurship project(No.2019-RC-65)
文摘Pain and depression are the most common neural responses to many harmful or harmful stimuli.The two are risk factors for each other.The comorbid relationship between pain and depression makes clinical treatment difficult.Seeking an analgesic and antidepressant is an urgent goal of clinical management of pain and depression.Melatonin(N-acetyl-5-methoxytryptamine)secreted by the pineal gland has multiple functions,including anti-inflammatory,antioxidant,immunomodulatory,sedative and analgesic.The effectiveness,safety,and basic non-toxic side effects of melatonin as an analgesic and antidepressant have been demonstrated in various pain animal models,which makes melatonin different in pathological conditions and during surgery.It has been used clinically in patients.Melatonin-mediated analgesic and antidepressant effects may involve inflammatory factors,astrocytes,protein kinase C(PKC)/N-methyl-D-aspartate(NMDA)pathway.However,there are few reports about the mechanism of melatonin in pain syndrome and depression in China.Therefore,this article summarizes the analgesic and antidepressant mechanism of melatonin by consulting domestic and foreign literatures.Provide theoretical basis for clinical treatment of related diseases.
文摘Chronic pain is one of the major complaints from patients seen in all acupuncture clinics.The most common principle to treat pain with acupuncture is to activate channels to relieve pain;however,little attention has been paid to treating the patient’s shen when treating their pain.This article is an introduction to the incorporation of the treatment of shen when treating chronic pain with acupuncture.The discussion of the shen and its treatments in this article are based on the review and study of the theories and principles in the ancient classics of traditional Chinese medicine.Shen is the interaction between yin and yang.Shen is the governor of life;it controls all physical and mental activities.Shen enables us to feel pain.The disorders of shen in pain sufferers can negatively affect how they feel or recognize pain,how they response to pain and how they report their pain level.We should pay more attention to the treatment of patient’s shen during the entire treatment course of chronic pain.Guarding shen is the key to acupuncture efficacy;the essential principles are harmonizing yin and yang by needling techniques and regulating hun and po at the needling sites.
文摘Objective:The aim of this scoping review was to provide evidence for health practitioners to improve patient education practice for chronic pain management.Methods:A scoping review was guided by Arksey and O’Malley’s(2005)1 five-stage framework,investigated contemporary patient education programs(2007–2018)for chronic pain management in education content,formats of delivery,and tools used for evaluation.Content analysis and description were used for the outcome report.Results:Seven quantitative studies were included.Education content consisted of General information,Cognitive behavior therapy(CBT),Self-management,and Pain neurophysiology(PN).Education delivery formats varied from workbook to workbook,face-toface,online,when given for a group or individual or in a combined way.In total,19 tools were reported for the evaluation of the education programs.Conclusions:There is a variety in the education content and the delivery formats.The majority of programs showed effectiveness in patients’chronic pain management based on their selected evaluation tools.This review showed that patient education programs can be useful in chronic pain management.The effectiveness of patient education programs focuses on the improved patients’physical function and quality of life rather than the cessation of pain only.
文摘BACKGROUND The literature suggests that there is a high degree of co-occurrence between chronic pain and posttraumatic stress disorder(PTSD). An association has been found between PTSD and substance abuse. PTSD is a severe disorder that should be taken into account when opioids are prescribed. It has been found that the prevalence of opioid use disorder(OUD) in chronic pain patients is higher among those with PTSD than those without this disorder.AIM To perform a systematic review on the association between PTSD, chronic noncancer pain(CNCP), and opioid intake(i.e., prescription, misuse, and abuse).METHODS We conducted a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The Patient, Intervention,Comparator, and Outcomes(PICOS) criteria were formulated a priori in the protocol of the systematic review. A search was conducted of the PROSPERO database. In March 2019, searches were also conducted of 5 other databases:Pub Med, MEDLINE, Psyc INFO, Web of Science, and PILOTS. The Scottish Intercollegiate Guidelines Network checklist for cohort studies was used to assess the selected studies for their methodological quality and risk of bias. Each study was evaluated according to its internal validity, participant sampling,confounding variables, and the statistical analysis.RESULTS A total of 151 potentially eligible studies were identified of which 17 were retained for analysis. Only 10 met the selection criteria. All the studies were published between 2008 and 2018 and were conducted in the United States. The eligible studies included a total of 1622785 unique participants. Of these, 196516 had comorbid CNCP and PTSD and were consuming opiates. The participants had a cross-study mean age of 35.2 years. The majority of participants were men(81.6%). The most common chronic pain condition was musculoskeletal pain:back pain(47.14% across studies;range: 16%-60.6%), arthritis and joint pain(31.1%;range: 18%-67.5%), and neck pain(28.7%;range: 3.6%-63%). In total,42.4% of the participants across studies had a diagnosis of PTSD(range: 4.7%-95%). In relation to opioid intake, we identified 2 different outcomes: opioid prescription and OUD. All the studies reported evidence of a greater prevalence of PTSD in CNCP patients who were receiving prescribed opioids and that PTSD was associated with OUD in CNCP patients.CONCLUSION Opioid analgesic prescription as the treatment of choice for CNCP patients should include screening for baseline PTSD to ensure that these drugs are safely consumed.
文摘In this study, we examined extensive narratives prepared by participants who attended a chronic pain management programme where therapeutic writing was included. The aim was to explore how narrators experience the contexts in which their lives unfold following a cognitive behavioural programme. The analysis was based on a three-sphere model for context analysis, which referred to the contexts in which the narrators located their life stories: their immediate inter-subjective relationships, the collective social field, and broad cultural meaning. We identified important change processes related to adaptation. Our examination of the experience of therapeutic writing clearly indicated that therapeutic writing is helpful. We suggest that obtaining a better understanding of living with chronic pain through storytelling as part of therapeutic writing and using a three-sphere model for context analysis could improve understanding and approaches to nursing. Health carers should organize care around the experience of illness and its inter-subjective, social, and cultural consequences, which may provide a deeper understanding of identity and the core themes embedded in life stories.
文摘Pain is a common event in many scenarios involving healthcare, from birth to death, in the hospital or outside of it. The overall purpose of this work was to critically review articles on types of pain and options employed in managing pain. Some electronic sources like google scholar, Ovid MEDLINE, PsychINFO, Embase were used to source for information. The articles were reviewed according to the various themes of the topic. From the different sources pain is categorized as acute or chronic with physical, psychological and social characteristics. Effective management of pain utilizes both pharmacologic and non-pharmacologic therapy. Pharmacological therapy employs non-opioids medications. Prolonged or unnecessary use of opioids causes some harmful side effects to the patient. Non-pharmacologic therapy plays a significant role and should be included in the multidisciplinary treatment plan. Nurses are members of the healthcare team who spend most of their time with patients as such they must work in collaboration with other healthcare professionals to facilitate patient’s recovery from pain. Healthcare professionals should also make use of internationally recognized guidelines during practice.
文摘Objective: To analyze the intensity of chronic pain and pharmacotherapy in chronic renal patients on hemodialysis. Method: This is a cross-sectional, prospective study conducted in a Service of Substitute Renal Therapy in the South region of Brazil. Seventy adult patients with chronic renal disease, who were undergoing hemodialysis treatment in the first half of 2015, participated in the study. We used the Graduated Scale for Chronic Pain. The data were analyzed with the Statistical Package for Social Sciences software version 18.0. The study was approved under N°. CAAE: 20138913.4.0000.0118. Results: Fifty-one (72%) patients reported some forms of pain in the last six months, 17 (24%) reported severely limiting pain, high interference and persistence. Painkillers were most widely used therapy for pain management, in 19 patients (27%). Conclusion: Chronic pain was reported in different degrees of intensity, with severely limiting character, high interference, and persistence. Painkillers were the most widely used pharmacological class to control it.
基金supported by the National Key Research and Development Program of China(Grant No.2018YFE0197900).
文摘Objective To screen the key genes of chronic pain and provide a reference for the treatment of chronic pain.Methods We performed comprehensive bioinformatics analysis by screening chronic primary pain-related datasets to obtain differentially expressed genes(DEGs)and then imported DEGs into the DAVID database for Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis.Gene Set Enrichment Analysis(GESA)analysis was done by GSEA_4.1.0 software.At the same time,we imported the intersecting genes into the STRING database and processed them by Cytoscape_3.8.1 software to obtain the protein-protein interaction(PPI)network and the central gene.Results As a result,a total of 54 DEGs were screened,including 47 up-regulated genes,1 down-regulated gene,and 6 genes that were expressed differently in different datasets.23 GO terms and 8 KEGG pathways were enriched by DAVID.PPI network analysis found that SPI1,STAT3,TNFRSF1B,PTGS2,and CXCL1 genes interacted more strongly with other genes,and were predicted to be key genes in chronic primary pain.Conclusion Our results suggested that 5 DEGs,STAT3,SPI1,TNFRSF1B,PTGS2,and CXCL1,have the potential to be used as prognostic and predictive markers for the clinical management of patients with this disease.
基金supported partially by two grants from the National Natural Science Foundation of China,No.30870686 and 81371530
文摘A reduction in gray matter volume is common in patients with chronic back pain,and different types of pain are associated with gray matter abnormalities in distinct brain regions.To examine differences in brain morphology in patients with low back pain or neck and upper back pain,we investigated changes in gray matter volume in chronic back pain patients having different sites of pain using voxel-based morphometry.A reduction in cortical gray matter volume was found primarily in the left postcentral gyrus and in the left precuneus and bilateral cuneal cortex of patients with low back pain.In these patients,there was an increase in subcortical gray matter volume in the bilateral putamen and accumbens,right pallidum,right caudate nucleus,and left amygdala.In upper back pain patients,reduced cortical gray matter volume was found in the left precentral and left postcentral cortices.Our findings suggest that regional gray matter volume abnormalities in low back pain patients are more extensive than in upper back pain patients.Subcortical gray matter volume increases are found only in patients with low back pain.
