Objective:Nature theory of Chinese medicine (CM) is the core basic theory of Traditional Chinese Medicine (TCM), in which cold-hot nature is the focus of research. Studies have found that CM ingredients are the materi...Objective:Nature theory of Chinese medicine (CM) is the core basic theory of Traditional Chinese Medicine (TCM), in which cold-hot nature is the focus of research. Studies have found that CM ingredients are the material basis for the production of medicine natures. Therefore, it is speculated that CMs with similar composition of substances should have similar medicinal nature. Modern work studies cold-hot medicine of CMs with chemical fingerprinting technology because the chemical fingerprint data of CM can reflect the whole composition of CM ingredients. Methods:To verify the hypothesis above, in this work, we study quantifying the similarity of CM ingredients to fingerprint similarity, and explore the relationship between the composition of CMs and cold-hot nature. Firstly, we utilize ultraviolet (UV) spectrum technology to analyze 61 CMs, which have clear cold-hot nature (including 30 ‘cold’ CMs and 31 ‘hot’ CMs). Secondly, with the constructed fingerprint database of CMs, a distance metric learning algorithm is studied to metric the similarity of UV fingerprints. Finally, a retrieval scheme is proposed to build a predictive identification model to identify cold-hot nature of CMs. Results:By means of numerous experiment analyses, ultraviolet spectrum data of petroleum ether solvent can better represent CMs to distinguish between cold and hot natures. Comparing with existing classical models, the proposed identification scheme has better predictive performance. Conclusion:The experimental results prove our inference that CMs with similar composition of substances should have similar medicinal nature. The proposed prediction model is proved to be effective and feasible.展开更多
为了在数据密集型工作流下有效降低缓存碎片整理开销并提高缓存命中率,提出一种持久性分布式文件系统客户端缓存DFS-Cache(Distributed File System Cache)。DFS-Cache基于非易失性内存(NVM)设计实现,能够保证数据的持久性和崩溃一致性...为了在数据密集型工作流下有效降低缓存碎片整理开销并提高缓存命中率,提出一种持久性分布式文件系统客户端缓存DFS-Cache(Distributed File System Cache)。DFS-Cache基于非易失性内存(NVM)设计实现,能够保证数据的持久性和崩溃一致性,并大幅减少冷启动时间。DFS-Cache包括基于虚拟内存重映射的缓存碎片整理机制和基于生存时间(TTL)的缓存空间管理策略。前者基于NVM可被内存控制器直接寻址的特性,动态修改虚拟地址和物理地址之间的映射关系,实现零拷贝的内存碎片整理;后者是一种冷热分离的分组管理策略,借助重映射的缓存碎片整理机制,提升缓存空间的管理效率。实验采用真实的Intel傲腾持久性内存设备,对比商用的分布式文件系统MooseFS和GlusterFS,采用Fio和Filebench等标准测试程序,DFS-Cache最高能提升5.73倍和1.89倍的系统吞吐量。展开更多
基金National key basic research development program (973 Program)(Grant No.:2007CB512600)National Natural Science Foundation of China (Grant No.:81473369)+1 种基金Key research and development plan of Shandong province (Grant No.:2016CYJS08A01-1)Shandong Province TCM science and technology development plan project (2019-0037).
文摘Objective:Nature theory of Chinese medicine (CM) is the core basic theory of Traditional Chinese Medicine (TCM), in which cold-hot nature is the focus of research. Studies have found that CM ingredients are the material basis for the production of medicine natures. Therefore, it is speculated that CMs with similar composition of substances should have similar medicinal nature. Modern work studies cold-hot medicine of CMs with chemical fingerprinting technology because the chemical fingerprint data of CM can reflect the whole composition of CM ingredients. Methods:To verify the hypothesis above, in this work, we study quantifying the similarity of CM ingredients to fingerprint similarity, and explore the relationship between the composition of CMs and cold-hot nature. Firstly, we utilize ultraviolet (UV) spectrum technology to analyze 61 CMs, which have clear cold-hot nature (including 30 ‘cold’ CMs and 31 ‘hot’ CMs). Secondly, with the constructed fingerprint database of CMs, a distance metric learning algorithm is studied to metric the similarity of UV fingerprints. Finally, a retrieval scheme is proposed to build a predictive identification model to identify cold-hot nature of CMs. Results:By means of numerous experiment analyses, ultraviolet spectrum data of petroleum ether solvent can better represent CMs to distinguish between cold and hot natures. Comparing with existing classical models, the proposed identification scheme has better predictive performance. Conclusion:The experimental results prove our inference that CMs with similar composition of substances should have similar medicinal nature. The proposed prediction model is proved to be effective and feasible.
文摘为了在数据密集型工作流下有效降低缓存碎片整理开销并提高缓存命中率,提出一种持久性分布式文件系统客户端缓存DFS-Cache(Distributed File System Cache)。DFS-Cache基于非易失性内存(NVM)设计实现,能够保证数据的持久性和崩溃一致性,并大幅减少冷启动时间。DFS-Cache包括基于虚拟内存重映射的缓存碎片整理机制和基于生存时间(TTL)的缓存空间管理策略。前者基于NVM可被内存控制器直接寻址的特性,动态修改虚拟地址和物理地址之间的映射关系,实现零拷贝的内存碎片整理;后者是一种冷热分离的分组管理策略,借助重映射的缓存碎片整理机制,提升缓存空间的管理效率。实验采用真实的Intel傲腾持久性内存设备,对比商用的分布式文件系统MooseFS和GlusterFS,采用Fio和Filebench等标准测试程序,DFS-Cache最高能提升5.73倍和1.89倍的系统吞吐量。
