Due to the increasing complexity of products and for the distributed product development, more closely collaborative work among designers is required. A collaborative assembly planning approach is proposed to support ...Due to the increasing complexity of products and for the distributed product development, more closely collaborative work among designers is required. A collaborative assembly planning approach is proposed to support assembly planning in a networked environment. The working procedure is depicted and the key techniques including collaborative-planning-oriented assembly decomposition modeling, assembly assignment modeling, and sub-plans merging are addressed. By incorporating visual models at client side with assembly application models at server side, a web-based supporting environment for collaborative assembly planning has been developed using VRML and Java-EAI techniques. A case study is given to illustrate the feasibility and validity of the idea.展开更多
Low-voltage electrical apparatuses(LVEAs)have many workpieces and intricate geometric structures,and the assembly process is rigid and labor-intensive,and has little balance.The assembly process cannot readily adapt t...Low-voltage electrical apparatuses(LVEAs)have many workpieces and intricate geometric structures,and the assembly process is rigid and labor-intensive,and has little balance.The assembly process cannot readily adapt to changes in assembly situations.To address these issues,a collaborative assembly is proposed.Based on the requirements of collaborative assembly,a colored Petri net(CPN)model is proposed to analyze the performance of the interaction and self-government of robots in collaborative assembly.Also,an artificial potential field based planning algorithm(AFPA)is presented to realize the assembly planning and dynamic interaction of robots in the collaborative assembly of LVEAs.Then an adaptive quantum genetic algorithm(AQGA)is developed to optimize the assembly process.Lastly,taking a two-pole circuit-breaker controller with leakage protection(TPCLP)as an assembly instance,comparative results show that the collaborative assembly is cost-effective and flexible in LVEA assembly.The distribution of resources can also be optimized in the assembly.The assembly robots can interact dynamically with each other to accommodate changes that may occur in the LVEA assembly.展开更多
Obesity plays a primary causative role in insulin resistance and hyperglycemia that contributes to type 2 diabetes.Excess lipid storage in the liver renders activation of the resident macrophages and chronic secretion...Obesity plays a primary causative role in insulin resistance and hyperglycemia that contributes to type 2 diabetes.Excess lipid storage in the liver renders activation of the resident macrophages and chronic secretion of inflammatory mediators,therefore causing or aggravating insulin resistance.Herein,we develop collaborative assemblies using a“one-pot”synthesis method for macrophage-specific delivery of small interfering RNAs(siRNAs)that target the inflammatory proteins.Ternary nanocomplex(NC)composed of the siRNA molecule,a synthetic thiol-bearing methacrylated hyaluronic acid(sm-HA)and protamine forms through an electrostatic-driven physical assembly,which is chemically crosslinked to acquire the collaboratively assembled nanocapsule(cNC)concurrently.The obtained cNC displays significantly higher stability than NC.Functional moieties as flexible assembly units can be easily equipped on cNC for long circulation,active targeting,or controlled siRNA release.cNC-F decorated with folic acid,a macrophage-targeting ligand promotes the siRNA accumulation in the activated macrophages in the liver of the obese mouse model.cNC-F loaded with siRNA targeting inflammatory indicators efficiently control the macrophage inflammatory response by reducing the expression of the inflammatory proteins(>40%reduction)and ameliorating the insulin resistance symptoms of the obese mice.展开更多
基金This research is supported by National Nature Science Foundation of China (NSFC) under the project number 59990470-2.
文摘Due to the increasing complexity of products and for the distributed product development, more closely collaborative work among designers is required. A collaborative assembly planning approach is proposed to support assembly planning in a networked environment. The working procedure is depicted and the key techniques including collaborative-planning-oriented assembly decomposition modeling, assembly assignment modeling, and sub-plans merging are addressed. By incorporating visual models at client side with assembly application models at server side, a web-based supporting environment for collaborative assembly planning has been developed using VRML and Java-EAI techniques. A case study is given to illustrate the feasibility and validity of the idea.
基金supported by the National Natural Science Foundation of China(No.52175124)the Zhejiang Provincial Natural Science Foundation of China(No.LZ21E050003)the Fundamental Research Funds for Zhejiang Universities,China(No.RF-C2020004)。
文摘Low-voltage electrical apparatuses(LVEAs)have many workpieces and intricate geometric structures,and the assembly process is rigid and labor-intensive,and has little balance.The assembly process cannot readily adapt to changes in assembly situations.To address these issues,a collaborative assembly is proposed.Based on the requirements of collaborative assembly,a colored Petri net(CPN)model is proposed to analyze the performance of the interaction and self-government of robots in collaborative assembly.Also,an artificial potential field based planning algorithm(AFPA)is presented to realize the assembly planning and dynamic interaction of robots in the collaborative assembly of LVEAs.Then an adaptive quantum genetic algorithm(AQGA)is developed to optimize the assembly process.Lastly,taking a two-pole circuit-breaker controller with leakage protection(TPCLP)as an assembly instance,comparative results show that the collaborative assembly is cost-effective and flexible in LVEA assembly.The distribution of resources can also be optimized in the assembly.The assembly robots can interact dynamically with each other to accommodate changes that may occur in the LVEA assembly.
基金supported by the National Natural Science Foundation of China(Nos.81673381,81971730,and 81773957)the National Science and Technology Major Projects for“Major New Drugs Innovation and Development”(No.2019ZX09201001-001-001)+2 种基金the Project of State Key Laboratory of Natural Medicines of China Pharmaceutical University(Nos.SKLNMZZCX201820 and SKLNMZZ202024)the“Double First-Class”Project of CPU(Nos.CPU2018GF05 and CPU2018GF04)the 111 Project(No.B16046).
文摘Obesity plays a primary causative role in insulin resistance and hyperglycemia that contributes to type 2 diabetes.Excess lipid storage in the liver renders activation of the resident macrophages and chronic secretion of inflammatory mediators,therefore causing or aggravating insulin resistance.Herein,we develop collaborative assemblies using a“one-pot”synthesis method for macrophage-specific delivery of small interfering RNAs(siRNAs)that target the inflammatory proteins.Ternary nanocomplex(NC)composed of the siRNA molecule,a synthetic thiol-bearing methacrylated hyaluronic acid(sm-HA)and protamine forms through an electrostatic-driven physical assembly,which is chemically crosslinked to acquire the collaboratively assembled nanocapsule(cNC)concurrently.The obtained cNC displays significantly higher stability than NC.Functional moieties as flexible assembly units can be easily equipped on cNC for long circulation,active targeting,or controlled siRNA release.cNC-F decorated with folic acid,a macrophage-targeting ligand promotes the siRNA accumulation in the activated macrophages in the liver of the obese mouse model.cNC-F loaded with siRNA targeting inflammatory indicators efficiently control the macrophage inflammatory response by reducing the expression of the inflammatory proteins(>40%reduction)and ameliorating the insulin resistance symptoms of the obese mice.
