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Calcium-chelating peptides from rabbit bone collagen:characterization,identification and mechanism elucidation 被引量:2
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作者 Fuhuan Yuan Yu Fu +8 位作者 Liang Ma Hankun Zhu Yong Yu Xin Feng Yi Sun Hongjie Dai Xin Liu Zhengfang Liu Yuhao Zhang 《Food Science and Human Wellness》 SCIE CSCD 2024年第3期1485-1493,共9页
This study aimed to characterize and identify calcium-chelating peptides from rabbit bone collagen and explore the underlying chelating mechanism.Collagen peptides and calcium were extracted from rabbit bone by instan... This study aimed to characterize and identify calcium-chelating peptides from rabbit bone collagen and explore the underlying chelating mechanism.Collagen peptides and calcium were extracted from rabbit bone by instant ejection steam explosion(ICSE)combined with enzymatic hydrolysis,followed by chelation reaction to prepare rabbit bone peptide-calcium chelate(RBCP-Ca).The chelating sites were further analyzed by liquid chromatography-tandem mass(LC-MS/MS)spectrometry while the chelating mechanism and binding modes were investigated.The structural characterization revealed that RBCP successfully chelated with calcium ions.Furthermore,LC-MS/MS analysis indicated that the binding sites included both acidic amino acids(Asp and Glu)and basic amino acids(Lys and Arg),Interestingly,three binding modes,namely Inter-Linking,Loop-Linking and Mono-Linking were for the first time found,while Inter-Linking mode accounted for the highest proportion(75.1%),suggesting that chelation of calcium ions frequently occurred between two peptides.Overall,this study provides a theoretical basis for the elucidation of chelation mechanism of calcium-chelating peptides. 展开更多
关键词 Rabbit bone collagen peptide Peptide-calcium chelate Chelation mechanism Liquid chromatography-tandem mass(LC-MS/MS)
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Anti-skin aging effects and bioavailability of collagen tripeptide and elastin peptide formulations in young and middle-aged women 被引量:1
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作者 Shan Lu Silu Zhang +3 位作者 Yun Wang Jiayi Ni Tiantian Zhao Guoxun Xiao 《Journal of Dermatologic Science and Cosmetic Technology》 2024年第2期26-37,共12页
Background:Collagen peptides(CP),including tripeptides and elastin peptides(EP),are known for their in vitro and in vivo anti-skin aging effects.Despite positive results in animal models,the combination effects of CP ... Background:Collagen peptides(CP),including tripeptides and elastin peptides(EP),are known for their in vitro and in vivo anti-skin aging effects.Despite positive results in animal models,the combination effects of CP and EP and the bioavailability of CP in human studies,particularly in young and middle-aged women,remain underexplored.Objective:To evaluate the effects of an orally administered collagen drink combining CP and EP on the skin health of young and middle-aged women.Materials and Methods:A single-center,randomized,double-blind,parallel-controlled trial was conducted,utilizing the WONDERLABR fish collagen tripeptide beverage.Participants consumed the drink over an 8-week period.Results:Compared to the placebo group,the collagen drink group showed significant improvements in skin hydration(39.19%increase),transepidermal water loss(33.45%decrease),skin elasticity(25.37%increase),dermal collagen content(21.64%increase),pore size(7.94%decrease),wrinkle length(18.09%decrease),skin smoothness(2.85%improvement),and skin roughness(15.32%decrease).Overall pore volume decreased by 60%,and visual assessments indicated a decrease in skin luminosity by 15.20%and smoothness index by 22.55%.Mass spectrometry demonstrated a significant increase in collagen efficacy components,including blood pH and GPH levels(P<0.05).Conclusion:The study confirmed the combination nourishing and anti-skin aging effects of EP and CP on the skin of young and middle-aged women,demonstrating significant improvements in various skin parameters and good bioavailability of collagen peptides. 展开更多
关键词 collagen tripeptides Elastin peptides ANTI-AGING Skin protection Peptide absorption
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Estimation of cancer cell migration in biomimetic random/oriented collagen fiber microenvironments
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作者 姚静如 李国强 +8 位作者 姚喜耀 周连杰 叶志凯 刘艳平 郑栋天 唐婷 宋克纳 陈果 刘雳宇 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第5期749-756,共8页
Increasing data indicate that cancer cell migration is regulated by extracellular matrixes and their surrounding biochemical microenvironment,playing a crucial role in pathological processes such as tumor invasion and... Increasing data indicate that cancer cell migration is regulated by extracellular matrixes and their surrounding biochemical microenvironment,playing a crucial role in pathological processes such as tumor invasion and metastasis.However,conventional two-dimensional cell culture and animal models have limitations in studying the influence of tumor microenvironment on cancer cell migration.Fortunately,the further development of microfluidic technology has provided solutions for the study of such questions.We utilize microfluidic chip to build a random collagen fiber microenvironment(RFM)model and an oriented collagen fiber microenvironment(OFM)model that resemble early stage and late stage breast cancer microenvironments,respectively.By combining cell culture,biochemical concentration gradient construction,and microscopic imaging techniques,we investigate the impact of different collagen fiber biochemical microenvironments on the migration of breast cancer MDA-MB-231-RFP cells.The results show that MDA-MB-231-RFP cells migrate further in the OFM model compared to the RFM model,with significant differences observed.Furthermore,we establish concentration gradients of the anticancer drug paclitaxel in both the RFM and OFM models and find that paclitaxel significantly inhibits the migration of MDA-MB-231-RFP cells in the RFM model,with stronger inhibition on the high concentration side compared to the low concentration side.However,the inhibitory effect of paclitaxel on the migration of MDA-MB-231-RFP cells in the OFM model is weak.These findings suggest that the oriented collagen fiber microenvironment resembling the late-stage tumor microenvironment is more favorable for cancer cell migration and that the effectiveness of anticancer drugs is diminished.The RFM and OFM models constructed in this study not only provide a platform for studying the mechanism of cancer development,but also serve as a tool for the initial measurement of drug screening. 展开更多
关键词 microfluidic chip random collagen fiber microenvironment(RFM) oriented collagen fiber microenvironment(OFM) cancer cell migration
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Anti-abrasion collagen fiber-based membrane functionalized by UiO-66-NH_(2)with ultra-high efficiency and stability for oil-in-water emulsions separation
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作者 Xiaoxia Ye Rixin Huang +3 位作者 Zhihong Zheng Juan Liu Jie Chen Yuancai Lv 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第2期285-297,共13页
Membrane separation strategies offer promising platform for the emulsion separation.However,the low mechanical strength of membrane separation layers and the trade-off between separation flux and efficiency present si... Membrane separation strategies offer promising platform for the emulsion separation.However,the low mechanical strength of membrane separation layers and the trade-off between separation flux and efficiency present significant challenges.In this study,we report a CFM@UiO-66-NH_(2)membrane with high separation flux,efficiency and stability,through utilizing a robust anti-abrasion collagen fiber membrane(CFM)as the multifunctional support and UiO-66-NH_(2)by an in-situ growth as the separation layer.The high mechanical strength of the CFM compensated for the weakness of the separation layer,while the charge-breaking effect of UiO-66-NH_(2),along with the size sieving of its constituent separating layers and the capillary effect of the collagen fibers,contributed to the potential for efficient separation.Additionally,the CFM@UiO-66-NH_(2)membrane exhibited superhydrophilic properties,making it suitable for separating oil-in-water microemulsions and nanoemulsions stabilized by anionic surfactants.The membrane demonstrated remarkable separation efficiencies of up to 99.960%and a separation flux of370.05 L·m^(-2)·h^(-1).Moreover,it exhibits stability,durability,and abrasion resistance,maintaining excellent separation performance even when exposed to strong acids and alkalis without any damage to its structure and performance.After six cycles of reuse,it achieved a separation flux of 417.97 L·m^(-2)·h^(-1)and a separation efficiency of 99.747%.Furthermore,after undergoing 500 cycles of strong abrasion,the separation flux remained at 124.39 L·m^(-2)·h^(-1),with a separation efficiency of 99.992%.These properties make it suitable for the long-term use in harsh operating environments.We attribute these properties to the electrostatic effect resulting from the amino group on UiO-66-NH_(2)and its in-situ growth on the CFM,which forms a size-screening separation layer.Our work highlights the potential of the CFM@UiO-66-NH_(2)membrane as an environmentally friendly size-screening material for the efficient emulsion wastewater separation. 展开更多
关键词 collagen fibers Metal-organic frameworks Oil-in-water emulsion separation Size sieving
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Acupotomy ameliorates knee osteoarthritis-related collagen deposition and fibrosis in rabbit skeletal muscle through the TGF-β/Smad pathway
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作者 Tingyao Hu Einar Khavaza +7 位作者 Chuxi Liang Longfei Xing Xilin Chen Yue Xu Weiwei Ma Farid Mokhtari Juan Lu Changqing Guo 《Journal of Traditional Chinese Medical Sciences》 CAS 2024年第3期376-385,共10页
Objective:To investigate the effects of acupotomy on skeletal muscle fibrosis and collagen deposition in a rabbit knee osteoarthritis(KOA)model.Methods: Rabbits(n=18)were randomly divided into control,KOA,and KOA+acup... Objective:To investigate the effects of acupotomy on skeletal muscle fibrosis and collagen deposition in a rabbit knee osteoarthritis(KOA)model.Methods: Rabbits(n=18)were randomly divided into control,KOA,and KOA+acupotomy(Apo)groups(n=6).The rabbits in the KOA and Apo groups were modeled using the modified Videman's method for 6 weeks.After modeling,the Apo group was subjected to acupotomy once a week for 3 weeks on the vastus medialis,vastus lateralis,rectus femoris,biceps femoris,and anserine bursa tendons around the knee.The behavior of all animals was recorded,rectus femoris tissue was obtained,and histomorphological changes were observed using Masson staining and transmission electron microscopy.The expression of transforming growth factor-β1(TGF-β1),Smad 3,Smad 7,fibrillar collagen types I(Col-I)and III(Col-III)was detected using Western blot and real-time polymerase chain reaction(RT-PCR).Results: Histological analysis revealed that acupotomy improved the microstructure and reduced the collagen volume fraction of rectus femoris,compared with the KOA group(P=.034).Acupotomy inhibited abnormal collagen deposition by modulating the expression of fibrosis-related proteins and mRNA,thus preventing skeletal muscle fibrosis.Western blot and RT-PCR analysis revealed that in the Apo group,Col-I,and Col-III protein levels were significantly lower than those in the KOA group(both P<.01),same as Col-I and Col-III mRNA levels(P=.0031;P=.0046).Compared with the KOA group,the protein levels of TGF-β1 and Smad 3 were significantly reduced(both P<.01),as were the mRNA levels of TGF-β1 and Smad 3(P=.0007;P=.0011).Conversely,the levels of protein and mRNA of Smad 7 were significantly higher than that in the KOA group(P<.01;P=.0271).Conclusion: Acupotomy could alleviate skeletal muscle fibrosis and delay KOA progress by inhibiting collagen deposition through the TGF-β/Smad pathway in the skeletal muscle of KOA rabbits. 展开更多
关键词 ACUPOTOMY Knee osteoarthritis Skeletal muscle FIBROSIS collagen deposition
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Multiscale engineered artificial compact bone via bidirectional freeze-driven lamellated organization of mineralized collagen microfibrils
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作者 Lingwenyao Kong Yonggang Zhao +6 位作者 Yang Xiong Junlin Chen Shuo Wang Ziming Yan Huibin Shi Zhanli Liu Xiumei Wang 《Bioactive Materials》 SCIE CSCD 2024年第10期168-181,共14页
Bone,renowned for its elegant hierarchical structure and unique mechanical properties,serves as a constant source of inspiration for the development of synthetic materials.However,achieving accurate replication of bon... Bone,renowned for its elegant hierarchical structure and unique mechanical properties,serves as a constant source of inspiration for the development of synthetic materials.However,achieving accurate replication of bone features in artificial materials with remarkable structural and mechanical similarity remains a significant challenge.In this study,we employed a cascade of continuous fabrication processes,including biomimetic mineralization of collagen,bidirectional freeze-casting,and pressure-driven fusion,to successfully fabricate a macroscopic bulk material known as artificial compact bone(ACB).The ACB material closely replicates the composition,hierarchical structures,and mechanical properties of natural bone.It demonstrates a lamellated alignment of mineralized collagen(MC)microfibrils,similar to those found in natural bone.Moreover,the ACB exhibits a similar high mineral content(70.9%)and density(2.2 g/cm3)as natural cortical bone,leading to exceptional mechanical properties such as high stiffness,hardness,and flexural strength that are comparable to those of natural bone.Importantly,the ACB also demonstrates excellent mechanical properties in wet,outstanding biocompatibility,and osteogenic properties in vivo,rendering it suitable for a broad spectrum of biomedical applications,including orthopedic,stomatological,and craniofacial surgeries. 展开更多
关键词 Artificial compact bone bidirectional freeze-casting Mineralized collagen microfibril Hierarchical structures
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Skin care efficacy study of recombinant humanized collagen based on in vitro level
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作者 Jian Wang Yuhui Fan +3 位作者 Danfeng Li Ningwen Cheng Ling Li Yufeng Yu 《日用化学工业(中英文)》 CAS 北大核心 2024年第9期1030-1038,共9页
Studying the skin care efficacy of recombinant humanized collagen based on in vitro level.The stability of the recombinant humanized collagen was first analyzed by treating at different temperatures,then its skincare ... Studying the skin care efficacy of recombinant humanized collagen based on in vitro level.The stability of the recombinant humanized collagen was first analyzed by treating at different temperatures,then its skincare efficacy based on in vitro level was evaluated by detecting the inhibition rate of elastase,the inhibition rate of collagenase,the protein content of type I collagen in human fibroblasts,the inhibition of reactive oxygen species(ROS)with human keratinocytes,and the effects of the recombinant humanized collagen on the expression of hyaluronic acid(HA),filaggrin(FLG)and transglutaminase 1(TGM1)in keratinocytes.The results showed that recombinant humanized collagen was able to maintain stability at temperatures below 70℃.With regard to its skincare efficacy,recombinant humanized collagen could inhibit elastase and collagenase activities and promote the increase of type I collagen content in human fibroblasts.It also showed good inhibition of ROS in keratinocytes in vitro and could increase the expression of HA,FLG,and TGM1 in keratinocytes.In short,the recombinant humanized collagen exhibited a favourable skin care effect in vitro level.This study proved that it has potential firming,anti-wrinkle,moisturizing,and repairing efficacy,and is a valuable cosmetic raw material. 展开更多
关键词 recombinant humanized collagen stability human fibroblast cell in vitro keratinocytes skin care efficacy
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Exosomes from umbilical cord mesenchymal stromal cells promote the collagen production of fibroblasts from pelvic organ prolapse
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作者 Lei-Mei Xu Xin-Xin Yu +1 位作者 Ning Zhang Yi-Song Chen 《World Journal of Stem Cells》 SCIE 2024年第6期708-727,共20页
BACKGROUND Pelvic organ prolapse(POP)involves pelvic organ herniation into the vagina due to pelvic floor tissue laxity,and vaginal structure is an essential factor.In POP,the vaginal walls exhibit abnormal collagen d... BACKGROUND Pelvic organ prolapse(POP)involves pelvic organ herniation into the vagina due to pelvic floor tissue laxity,and vaginal structure is an essential factor.In POP,the vaginal walls exhibit abnormal collagen distribution and decreased fibroblast levels and functions.The intricate etiology of POP and the prohibition of trans-vaginal meshes in pelvic reconstruction surgery present challenges in targeted therapy development.Human umbilical cord mesenchymal stromal cells(hucMSCs)present limitations,but their exosomes(hucMSC-Exo)are promising therapeutic tools for promoting fibroblast proliferation and extracellular matrix remodeling.suppressed inflammation in POP group fibroblasts,stimulated primary fibroblast growth,and elevated collagen I(Col1)production in vitro.High-throughput RNA-seq of fibroblasts treated with hucMSC-Exo and miRNA sequencing of hucMSC-Exo revealed that abundant exosomal miRNAs downregulated matrix metalloproteinase 11(MMP11)expression.CONCLUSION HucMSC-Exo normalized the growth and function of primary fibroblasts from patients with POP by promoting cell growth and Col1 expression in vitro.Abundant miRNAs in hucMSC-Exo targeted and downregulated MMP11 expression.HucMSC-Exo-based therapy may be ideal for safely and effectively treating POP. 展开更多
关键词 Pelvic organ prolapse EXOSOMES FIBROBLASTS Human umbilical cord mesenchymal stromal cells Extracellular matrix collagen I
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Tissue Regeneration in Infected Wounds of Albino Rats Using Ciprofloxacin-Loaded Gelatin Microspheres Incorporated Collagen Scaffold: A Histological Approach with H&E Staining
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作者 Kirubanandan Shanmugam 《Journal of Clinical and Nursing Research》 2024年第5期156-168,共13页
A wound care system consisting of ciprofloxacin-loaded gelatin microspheres impregnated in a macroporous collagen scaffold was created to effectively control wound infection and regenerate soft tissue at the wound sit... A wound care system consisting of ciprofloxacin-loaded gelatin microspheres impregnated in a macroporous collagen scaffold was created to effectively control wound infection and regenerate soft tissue at the wound site.Histological and biochemical alterations were observed in infected wounds treated with these scaffolds in Albino Wistar rats.Furthermore,the study examined the immediate and prolonged release of ciprofloxacin from the scaffolds,as well as their function in eliminating bacterial infections and expediting the process of skin healing and regeneration.The developed technique was followed in the streamlined process of creating these collagen scaffolds.Compared to untreated wounds,the group receiving scaffold treatment experienced a faster rate of wound closure.It was noted that the rate of infections was considerably reduced and that full soft tissue regeneration occurred within 12 days.The development of well-deposited collagen bundles in the treated groups was demonstrated by H&E staining,which verified the flawless regeneration of the dermis and epidermis.The antimicrobial agent-loaded gelatin microspheres impregnated into the porous collagen scaffold demonstrated remarkable soft tissue regeneration and efficient infection control at the wound site. 展开更多
关键词 Gelatin microspheres collagen Controlled release Wound healing
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The Combined Effect of Lumenato and Ceramide in the Protection of Collagen Damage Induced by Neutrophils in Normal Human Dermal Fibroblasts
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作者 Yulia Solomonov Rachel Levy 《Advances in Bioscience and Biotechnology》 CAS 2024年第2期140-159,共20页
Introduction: Collagen is the primary structural protein fibroblasts produce in the skin’s extracellular matrix. Infiltration of neutrophils into the epidermis and dermis by exposure to UV causes collagen damage and ... Introduction: Collagen is the primary structural protein fibroblasts produce in the skin’s extracellular matrix. Infiltration of neutrophils into the epidermis and dermis by exposure to UV causes collagen damage and contributes to photoaging. Methods: To study the combined effect of Lumenato and ceramide in preventing collagen-1 damage induced by phagocytes, we used co-cultures of normal human dermal fibroblasts (fibroblasts) and activated human neutrophils. The present study aimed to determine the protective effect of the combination of Lumenato and ceramide on fibroblast collagen-1 damage induced by neutrophils. Results: Lumenato (in the range of 6.5 - 208 μg/ml) or ceramide (in the range of 0.1 - 50 μM) inhibited the production of superoxides and MPO by TNFα-stimulated neutrophils, as well as the production of NO by LPS-stimulated macrophages in a dose-dependent manner. The combinations of Lumenato and ceramide, in low concentrations, caused synergistic prevention of fibroblasts’ collagen-1 damage induced by TNFα-activated neutrophils, detected by fluorescence immunostaining and WB analysis. MPO activity in the supernatants of the co-cultures was also synergistically inhibited. Adding Lumenato or ceramide singly or in combinations in these low concentrations to the fibroblast cultures did not affect the expression of collagen-1. The combinations of Lumenato or ceramide in these concentrations also caused a synergistic inhibition of NO production by activated macrophages. Conclusions: The results suggest that combining low concentrations of Lumenato and ceramide results in synergistic protection against fibroblasts’ collagen-1 damage induced by neutrophils, thus indicating their possible potential for enhanced skin health. 展开更多
关键词 Dermal Fibroblasts NEUTROPHILS collagen-1 Lumenato CERAMIDE
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3D Collagen Gels:A Promising Platform for Dendritic Cell Culture in Biomaterials Research
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作者 Kirubanandan Shanmugam 《Proceedings of Anticancer Research》 2024年第4期124-134,共11页
The three-dimensional(3D)cell culture system has garnered significant attention in recent years as a means of studying cell behavior and tissue development,as opposed to traditional two-dimensional cultures.These syst... The three-dimensional(3D)cell culture system has garnered significant attention in recent years as a means of studying cell behavior and tissue development,as opposed to traditional two-dimensional cultures.These systems can induce specific cell reactions,promote specific tissue functions,and serve as valuable tools for research in tissue engineering,regenerative medicine,and drug discovery.This paper discusses current developments in the field of three-dimensional cell culture and the potential applications of 3D type 1 collagen gels to enhance the growth and maturation of dendritic cells. 展开更多
关键词 Three-dimensional cell culture Dendritic cells Type 1 collagen gels Bovine tendons and rat tails
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铸态下Sn-Bi二元共晶焊料合金的组织特征及其力学性能
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作者 唐玲 张会 +1 位作者 孟凡莹 刘艳 《有色金属工程》 CAS 北大核心 2024年第7期52-59,共8页
研究了四种不同Bi含量(45%、50%、55%、60%)的Sn-Bi二元共晶合金自由凝固下的组织特征和力学性能,探讨了Sn-Bi二元共晶合金的晶体生长机制以及Bi元素含量对合金显微组织的影响。结果表明:Sn-Bi二元亚共晶合金铸态下的金相组织为初生Sn... 研究了四种不同Bi含量(45%、50%、55%、60%)的Sn-Bi二元共晶合金自由凝固下的组织特征和力学性能,探讨了Sn-Bi二元共晶合金的晶体生长机制以及Bi元素含量对合金显微组织的影响。结果表明:Sn-Bi二元亚共晶合金铸态下的金相组织为初生Sn固溶体相和Sn/Bi共晶层片集群构成,随着Bi含量的增加,呈树枝晶形态生长的初生Sn相数量减少,形态长大。初生Sn固溶体相内部脱溶析出大量的杆状或点状Bi相,形成杆状共晶结构;Sn-Bi二元过共晶合金铸态下的金相组织为初生Bi相和Sn/Bi共晶层片集群构成,初生Bi相中基本不固溶Sn元素,呈小平面方式生长,并在在初生Bi相周围包裹生长一层Sn晕圈相。在室温下,Sn-Bi二元共晶合金的硬度和强度随着Bi含量的增加而上升,延伸率随着Bi含量的增加先上升后下降。 展开更多
关键词 Sn-bi二元共晶合金 杆状共晶 晕圈相 显微组织 力学性能
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基于不同Bi2WO6形貌下光催化降解四环素性能研究
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作者 于洋 郎春秋 +1 位作者 杜刚 王岩 《通化师范学院学报》 2024年第6期47-51,共5页
该文以Bi(NO3)3·5H2O和Na2WO4·2H2O为原料通过水热法合成Bi2WO6,重点研究通过改变水合加热时间和溶液酸碱性,不同合成条件对Bi2WO6产物形貌的影响.借助扫描电子显微镜(SEM)对Bi2WO6形貌进行分析.实验结果显示,溶液酸碱性和加... 该文以Bi(NO3)3·5H2O和Na2WO4·2H2O为原料通过水热法合成Bi2WO6,重点研究通过改变水合加热时间和溶液酸碱性,不同合成条件对Bi2WO6产物形貌的影响.借助扫描电子显微镜(SEM)对Bi2WO6形貌进行分析.实验结果显示,溶液酸碱性和加热时间均对Bi2WO6的形貌有较大影响,水合加热时间也对其形貌有很大的影响.此外,通过在可见光下降解四环素(TC),探讨了不同合成条件对催化剂性能的影响.实验结果表明,酸碱性会破坏Bi2WO6的结构,进而降低其光催化性能.当水合加热时间为25 h时,Bi2WO6的降解效率最高,降解效果约为50%. 展开更多
关键词 bi2WO6 水热法 SEM 光催化降解
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放电等离子体烧结BaTiO_(3-x)Bi(Ni_(0.5)Zr_(0.5))O_(3)陶瓷的介电和阻抗性能
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作者 肖长江 马金明 张群飞 《材料工程》 EI CAS CSCD 北大核心 2024年第5期203-211,共9页
采用传统固相反应法合成BaTiO_(3-x)Bi(Ni_(0.5)Zr_(0.5))O_(3)粉体和放电等离子体烧结技术制备BaTiO_(3-x)Bi(Ni_(0.5)Zr_(0.5))O_(3)陶瓷,研究陶瓷的晶体结构、微观形貌、介电和阻抗性能。结果表明:BaTiO_(3)-0.10Bi(Ni_(0.5)Zr_(0.5)... 采用传统固相反应法合成BaTiO_(3-x)Bi(Ni_(0.5)Zr_(0.5))O_(3)粉体和放电等离子体烧结技术制备BaTiO_(3-x)Bi(Ni_(0.5)Zr_(0.5))O_(3)陶瓷,研究陶瓷的晶体结构、微观形貌、介电和阻抗性能。结果表明:BaTiO_(3)-0.10Bi(Ni_(0.5)Zr_(0.5))O_(3)陶瓷具有钙钛矿型,晶体结构为赝立方相,晶粒尺寸约为0.64μm,密度为5.81 g/cm^(3),最大介电常数为7149,且随频率升高相变温度向高温移动。在1 kHz下,BaTiO_(3)-0.10Bi(Ni_(0.5)Zr_(0.5))O_(3)陶瓷的ln(1/ε-1/ε_(m))与ln(T-T_(m))的拟合曲线斜率为1.61,在-41~169℃内,Δε/ε_(25℃)≤±15%,表明样品有良好的温度稳定性。此外,随温度和频率的升高,材料的阻抗降低,在50℃下,当频率为100 Hz时,电阻为2.33×10~6Ω,离子电导率为10^(-8)S/cm。 展开更多
关键词 BaTiO_(3-x)bi(Ni_(0.5)Zr_(0.5))O_(3) 放电等离子体烧结 赝立方相 介电性能 弛豫特性 阻抗
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Mg-Bi系合金的研究进展
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作者 杨来东 陈晓亚 +3 位作者 刘浩锐 罗宏博 赵磊 王建吉 《功能材料》 CAS CSCD 北大核心 2024年第7期7038-7050,共13页
合金元素Bi的价格较低,在镁中有较高的固溶度,随着温度降低,其固溶度减小,析出Mg_(3)Bi_(2)相,提高了镁的力学性能,因此Mg-Bi系合金具有良好的固溶和时效硬化潜力。在Mg-Bi系合金中加入Sn、Mn、Al、Ca、Zn等元素,改善合金组织,能够进一... 合金元素Bi的价格较低,在镁中有较高的固溶度,随着温度降低,其固溶度减小,析出Mg_(3)Bi_(2)相,提高了镁的力学性能,因此Mg-Bi系合金具有良好的固溶和时效硬化潜力。在Mg-Bi系合金中加入Sn、Mn、Al、Ca、Zn等元素,改善合金组织,能够进一步提高合金的力学性能及耐腐蚀性。文中介绍了国内外学者对Mg-Bi系合金的研究进展,在总结Mg-Bi二元合金研究成果基础上,系统的概述了Mg-Bi-Sn系、Mg-Bi-Mn系、Mg-Bi-Al系、Mg-Bi-Ca系、Mg-Bi-Zn系等合金的组织和性能,综述了合金化对合金第二相、晶粒尺寸、织构、动态再结晶的影响,阐述了合金元素种类、添加量及热加工参数与合金力学性能的关系。总结了Mg-Bi系合金研究中存在的问题,并对今后的研究工作进行了展望。 展开更多
关键词 Mg-bi系合金 合金化 显微组织 力学性能
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基于聚类的HPO-BILSTM光伏功率短期预测 被引量:2
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作者 周育才 肖添 +2 位作者 谢七月 付强 钟敏 《太阳能学报》 EI CAS CSCD 北大核心 2024年第4期512-518,共7页
考虑到光伏发电功率在不同天气类型下的波动性和不确定性,对此提出一种基于模糊C均值聚类算法(FCM)和猎食者优化算法(HPO)优化双向长短期记忆网络(BILSTM)的光伏发电短期功率预测模型。首先对光伏发电数据进行处理和分析,再进行主成分分... 考虑到光伏发电功率在不同天气类型下的波动性和不确定性,对此提出一种基于模糊C均值聚类算法(FCM)和猎食者优化算法(HPO)优化双向长短期记忆网络(BILSTM)的光伏发电短期功率预测模型。首先对光伏发电数据进行处理和分析,再进行主成分分析(PCA)降维和FCM聚类算法将数据按天气类型分为阴、晴、雨;最后通过HPO筛选得出BILSTM神经网络的最佳超参数,避免因超参数设置不佳对实验带来的影响,进一步提高实验的准确性和模型的泛化能力。最后通过预测和对比实验进行分析,验证所提方法的优越性。 展开更多
关键词 光伏发电 双向长短期记忆网络 功率预测 降维 聚类 优化算法
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Bi-SnO_(2)电催化膜的制备及对饮用水中卡马西平的强化去除
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作者 魏永 郭子寅 +3 位作者 袁学锋 李克英 周晨 孙甜 《中国环境科学》 EI CAS CSCD 北大核心 2024年第5期2543-2553,共11页
以家用净水器活性炭滤芯为支撑体(Carbon membrane,CM),通过电沉积法制备Bi-SnO_(2)电催化膜(Bi-SnO_(2)/CM),通过电催化强化降解饮用水中的PPCPs.采用SEM、EDS、XRD分别对CM、SnO_(2)/CM和Bi-SnO_(2)/CM进行了结构表征,并利用Tafel、CV... 以家用净水器活性炭滤芯为支撑体(Carbon membrane,CM),通过电沉积法制备Bi-SnO_(2)电催化膜(Bi-SnO_(2)/CM),通过电催化强化降解饮用水中的PPCPs.采用SEM、EDS、XRD分别对CM、SnO_(2)/CM和Bi-SnO_(2)/CM进行了结构表征,并利用Tafel、CV、EIS方法对3种膜的析氧电势、比电容和电化学阻抗等电化学特性进行表征,并选取卡马西平(Carbamazepine,CBZ)作为PPCPs代表物进行电催化效能试验研究.结果表明:采用电沉积-水热方法制备的Bi-SnO_(2)纳米颗粒的粒径尺寸约为27.2nm,可以很好地负载到活性炭滤芯表面,并制备出电化学性能优异的电催化膜,相比基膜其Tafel斜率由31.09mV/dec增至80.22mV/dec,电化学阻抗由1.03Ωcm^(2)降低为0.37Ωcm^(2),比电容也由0.689F/g增至2.635F/g.最终通过实验验证了其对卡马西平的降解效果,在静态循环实验中,Bi-SnO_(2)/CM对CBZ的去除率30min可达到97.3%,在运行1h后矿化率为59.2%,耗能为123.87kW·h/kgTOC,ΔTMP为0.177kPa.在连续运行时,Bi-SnO_(2)/CM对CBZ的去除率达93.7%,在运行1h后矿化率为35.2%,耗能为208.33kW·h/kgTOC,ΔTMP为0.613kPa.说明Bi-SnO_(2)/CM电催化膜具有良好的导电性、电催化活性和稳定性,同时对CBZ具有较好的去除效果. 展开更多
关键词 电沉积 SnO_(2) bi-SnO_(2) 电催化膜 卡马西平
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基于CNN-BiGRU-Attention的短期电力负荷预测 被引量:2
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作者 任爽 杨凯 +3 位作者 商继财 祁继明 魏翔宇 蔡永根 《电气工程学报》 CSCD 北大核心 2024年第1期344-350,共7页
针对目前电力负荷数据随机性强,影响因素复杂,传统单一预测模型精度低的问题,结合卷积神经网络(Convolutional neural network,CNN)、双向门控循环单元(Bi-directional gated recurrent unit,BiGRU)以及注意力机制(Attention)在短期电... 针对目前电力负荷数据随机性强,影响因素复杂,传统单一预测模型精度低的问题,结合卷积神经网络(Convolutional neural network,CNN)、双向门控循环单元(Bi-directional gated recurrent unit,BiGRU)以及注意力机制(Attention)在短期电力负荷预测上的不同优点,提出一种基于CNN-BiGRU-Attention的混合预测模型。该方法首先通过CNN对历史负荷和气象数据进行初步特征提取,然后利用BiGRU进一步挖掘特征数据间时序关联,再引入注意力机制,对BiGRU输出状态给与不同权重,强化关键特征,最后完成负荷预测。试验结果表明,该模型的平均绝对百分比误差(Mean absolute percentage error,MAPE)、均方根误差(Root mean square error,RMSE)、判定系数(R-square,R~2)分别为0.167%、0.057%、0.993,三项指标明显优于其他模型,具有更高的预测精度和稳定性,验证了模型在短期负荷预测中的优势。 展开更多
关键词 卷积神经网络 双向门控循环单元 注意力机制 短期电力负荷预测 混合预测模型
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基于Bo-BiLSTM网络的IGBT老化失效预测方法 被引量:1
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作者 万庆祝 于佳松 +1 位作者 佟庆彬 闵现娟 《电气技术》 2024年第3期1-10,共10页
针对绝缘栅双极型晶体管(IGBT)受热应力冲击后对其进行老化失效预测精度不高的情况,提出一种基于贝叶斯优化(Bo)-双向长短期记忆(BiLSTM)网络的IGBT老化失效预测方法。首先分析IGBT模块老化失效原理,然后基于NASA老化实验数据集建立失... 针对绝缘栅双极型晶体管(IGBT)受热应力冲击后对其进行老化失效预测精度不高的情况,提出一种基于贝叶斯优化(Bo)-双向长短期记忆(BiLSTM)网络的IGBT老化失效预测方法。首先分析IGBT模块老化失效原理,然后基于NASA老化实验数据集建立失效特征数据库,最后利用Matlab软件构造Bo-BiLSTM网络预测失效特征参数数据。选取常用回归预测性能评估指标将长短期记忆(LSTM)网络模型、BiLSTM网络模型与Bo-BiLSTM网络模型的预测结果进行对比分析。结果表明,Bo-BiLSTM网络的模型拟合精度更高,基于Bo-BiLSTM网络的IGBT老化失效预测方法具有较好的预测效果,能够应用于IGBT的失效预测。 展开更多
关键词 绝缘栅双极型晶体管(IGBT) 贝叶斯优化 双向长短期记忆(biLSTM)网络 老化失效预测
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老年腹部手术患者BIS监测下异丙酚闭环与开环靶控输注模式的麻醉效果比较
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作者 姚朋 张丹 《临床心身疾病杂志》 CAS 2024年第3期51-55,共5页
目的探讨脑电双频指数(BIS)监测下异丙酚闭环与开环靶控输注在老年腹部手术患者中的麻醉效果。方法将76例老年腹部手术患者按照随机数字表法分为对照组38例[采用异丙酚开环靶控输注(OLTCI)]和研究组38例[采用异丙酚闭环靶控输注(CLTCI)... 目的探讨脑电双频指数(BIS)监测下异丙酚闭环与开环靶控输注在老年腹部手术患者中的麻醉效果。方法将76例老年腹部手术患者按照随机数字表法分为对照组38例[采用异丙酚开环靶控输注(OLTCI)]和研究组38例[采用异丙酚闭环靶控输注(CLTCI)]。比较两组患者的麻醉效果、麻醉药物使用情况、不同时间阶段血流动力学指标以及手术相关指标。结果在麻醉诱导阶段和麻醉维持阶段,研究组患者麻醉满意时间占比高于对照组,麻醉过深时间占比低于对照组,且麻醉维持阶段的麻醉过浅时间占比低于对照组(P<0.05或0.01)。研究组患者异丙酚诱导总量少于对照组,每小时泵调整次数多于对照组(P<0.01)。两组患者意识消失、插管即刻、插管后1 min时的心率(HR)均慢于麻醉诱导前,但研究组患者意识消失、插管即刻、插管后1 min时的HR均快于对照组(P<0.05或0.01)。研究组患者诱导阶段各时期的平均动脉压(MAP)水平无明显变化(P>0.05)。对照组患者意识消失、插管即刻、插管后1 min时的MAP水平均低于麻醉诱导前,且插管即刻、插管后1 min时的MAP水平低于研究组(P<0.05或0.01)。两组患者手术时间、麻醉时间、拔管时间、苏醒时间以及恶心、呕吐发生率等手术相关指标比较,差异无统计学意义(P>0.05)。结论对老年腹部手术患者行BIS监测下异丙酚CLTCI时,可按照BIS的数值及时调整异丙酚用量,避免了血流动力学指标的大幅度波动,可减少麻醉药物的用量,值得临床大力推广。 展开更多
关键词 脑电双频指数 异丙酚 闭环靶控输注 开环靶控输注 老年 腹部手术
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