Agricultural mechanization plays a pivotal role in the transition from subsistence to commercial agriculture, with a particular focus on labour-intensive activities like harvesting. This study assesses the operational...Agricultural mechanization plays a pivotal role in the transition from subsistence to commercial agriculture, with a particular focus on labour-intensive activities like harvesting. This study assesses the operational characteristics of the BRRI Whole Feed Combine Harvester (Model BRRI WCH2021) at the field level. Developed under the SFMRA project, the harvester’s technical performance and loss assessment were conducted during the Boro 2022 and Aman 2022 seasons in farmer fields in Bangladesh’s Rangpur region. The field efficiency of the harvester was determined to be 62.5% and 57.9% in the Boro and Aman seasons, respectively. Fuel consumption rates were recorded at 2.77 l/ha and 2.31 l/ha for the Boro and Aman seasons. The total harvesting losses, encompassing cutter bar, shatter, cylinder, and separation loss, averaged 0.56% and 0.48% in the Boro and Aman seasons, respectively. Mechanized harvesting with the BRRI Whole Feed Combine Harvester significantly reduced paddy losses by 5.81% compared to manual methods. The field evaluation results indicate the combine harvester’s satisfactory performance, highlighting its potential to alleviate labour demands during peak harvesting. The development of the BRRI WCH offers a sustainable solution for rice harvesting mechanization among progressive farmers. It paves the way for the broader adoption of advanced agricultural technology in Bangladesh.展开更多
A study was conducted at PAU Regional Research Station, Gurdaspur (Punjab) to investigate the design and operational parameters of threshing mechanism of conventional combine harvester for basmati crop. This study was...A study was conducted at PAU Regional Research Station, Gurdaspur (Punjab) to investigate the design and operational parameters of threshing mechanism of conventional combine harvester for basmati crop. This study was aimed to investigate the suitable changes required in the self-propelled conventional combine harvester for harvesting the basmati crop with minimum grain losses. Field evaluation of experiment was carried out to assess the influence of independent design variable <em>i.e.</em>, arrangement of spikes (AS) and independent operational parameters such as concave clearance (CC) and cylinder speed (CS). The study was aimed to enumerate various combining losses<em> viz</em>., extent of visible and invisible grain damage and threshing efficiency at different AS, CC and CS levels. The first year data recorded during 2017 were processed for the optimization during 2018. The results of the present study revealed that during 2017, maximum visible and invisible losses was 5.49% ± 0.33% and 28.07% ± 3.21%, respectively whereas after modification, these losses remained only 4.00% ± 0.80% and 24.07% ± 2.86%, respectively. The threshing efficiency remained above 99.31% ± 0.47%, for both years. Thus, optimization of combine harvester was able to save the visible grain damage by 60% to 83% and invisible grain damage by 6% to 16%, respectively during 2018 than the year 2017.展开更多
Bangladesh, a country with 87% of rural households that depend on agriculture and rice dominated diets (70%), engages the country’s food security. Therefore, there is strong advocacy for a mechanized paddy harvesting...Bangladesh, a country with 87% of rural households that depend on agriculture and rice dominated diets (70%), engages the country’s food security. Therefore, there is strong advocacy for a mechanized paddy harvesting system for food security in South Asia, mainly Bangladesh. Some harvesting machinery is available;however, the precise roles of a combine harvester during this process are little. This study attempts to understand the consequences of combining harvesters for paddy harvesting and compare them with hand harvesting. For comparison of field performance of combine harvester with traditional harvesting, the experiment was conducted at Gazipur District, Bangladesh, in 2016. Results showed that the labor required for harvesting unit area 283, 15 and 9.87 man-h∙ha<sup>−1</sup> for T<sub>1</sub> (Sickle + Head carry + Beating + Kula), T<sub>2</sub> (Reaper + Trolley carry + Close drum thresher + winnower), T<sub>3</sub> (Combine harvester) system, respectively. Likewise, the harvesting costs were 1.84 (T<sub>2</sub>) and 2.5 (T<sub>1</sub>) times higher than the combine harvester (T<sub>3</sub>). Also, the postharvest loss can be saved 1.84%, to use combine harvester over manual harvesting of paddy. The above result revealed that the semi-mechanized and mechanized harvesting system is a time, labor and cost-saving system;however, the manual reaping system is concerned with more postharvest losses (3.09%). This study highlights the importance of combine harvester;however, further research is required in other places with large and mini-combine harvesters under diverse cropping areas and to test a combine harvester’s detailed potentiality.展开更多
To improve the automation level and operation quality of China's beet harvester and reduce the loss due to damaged and missed excavation,this study used a self-developed sugar beet combine harvester and field simu...To improve the automation level and operation quality of China's beet harvester and reduce the loss due to damaged and missed excavation,this study used a self-developed sugar beet combine harvester and field simulation experiment platform,based on the single-factor bench test of the automatic row following system in the early stage,taking hydraulic flow A,spring preload B,and forward speed C which have significant influence on performance indices as test factors,and taking the missed excavation rate,breakage rate and reaction time as performance indices,the orthogonal experimental study on the parameter optimization of the three-factor and three-level automatic row following system with the first-order interaction of various factors was carried out.The results of the orthogonal experiments were analyzed using range analysis and variance analysis.The results showed that there were differences in the influence degree,factor priority order and first-order interaction,and the optimal parameter combination on each performance index.A weighted comprehensive scoring method was used to optimize and analyze each index.The optimal parameter combination of the overall operating performance of the automatic row following system was A 2B 2C 1,that is,the hydraulic flow was 25 L/min,the forward speed was 0.8 m/s,and the spring preload was 198 N.Under this combination,the response time was 0.496 s,the missed excavation rate was 2.35%,the breakage rate was 3.65%,and the operation quality was relatively good,which can meet the harvest requirements.The comprehensive optimization results were verified by field experiments with different ridge shapes and different planting patterns.The results showed that the mean values of the missed excavation rate of different planting patterns of conventional straight ridges and extremely large"S"ridges were 2.23%and 2.69%,respectively,and the maximum values were 2.39%and 2.98%,respectively;the average damage rates were 3.38%and 4.14%,and the maximum values were 3.58%and 4.48%,which meet the industry standards of sugar beet harvester operation quality.The overall adaptability of the automatic row following system is good.This study can provide a reference for research on automatic row following harvesting systems of sugar beets and other subsoil crop harvesters.展开更多
Existing development for cyclone separation cleaning components of the rapeseed combine harvester,which employs the suspending airflow to separate the rapeseeds from the materials other than grain(MOG),has the challen...Existing development for cyclone separation cleaning components of the rapeseed combine harvester,which employs the suspending airflow to separate the rapeseeds from the materials other than grain(MOG),has the challenge to figure out the optimal working parameters,highlighting a need for exploration of the invisible airflow based on Computational Fluid Dynamics(CFD).The airflow status was mainly affected by the air velocities of the inlet,and the outlet for the MOG.The single factor and response surface experiments were carried out.It could be found that the inlet and MOG outlet velocities affected the air velocities through the change in the air quantity.Furthermore,the mathematical model of the relationship between the air velocities inside the cyclone and the working parameters was built,and the optimal combination of working parameters was obtained by multi-objective optimization.The inlet and outlet velocities of the optimal combination were 4.25 m/s and 29.87 m/s,respectively.Under this condition,the cleaning ratio and loss ratio of the cleaning device was 94.62%and 5.39%,respectively,as validated by the field experiment.The findings provide references for the improvement of cleaning systems for rapeseed combine harvesters.展开更多
In order to meet the challenge of high loss rate and high tuber injury rate during the operation of the 4UZL-1 sweet potato combine harvester,the sweet potato tuber hand-over lifting mechanism was designed based on a ...In order to meet the challenge of high loss rate and high tuber injury rate during the operation of the 4UZL-1 sweet potato combine harvester,the sweet potato tuber hand-over lifting mechanism was designed based on a comprehensive analysis of the entire structure of the harvester.Taking the average normal force on conveying sweet potato tubers as evaluation indexes,the EDEM simulation experiment was carried out considering the factors of the angle of the excavating and conveying mechanism,the conveying angle of the scraper chain,the speed of the excavating and conveying mechanism,and the speed of the scraper chain conveying.The experimental findings indicated that the optimal operational performance of the hand-over lifting mechanism was achieved at a speed of 1.15 m/s for the excavating and conveying mechanism,an angle of 24°for the excavating and conveying mechanism,a conveying speed of 0.66 m/s for the scraper chain,and a conveying angle of 60°for the scraper chain.Field experiments were conducted based on the EDEM simulation experiment,using the loss rate and the injury rate of conveying sweet potato tubers as evaluation indexes.The results showed that the hand-over lifting mechanism demonstrated optimal operational effectiveness with an excavating and conveying mechanism angle of 20°,a scraper chain angle of 68°,an excavating and conveying mechanism speed of 1.2 m/s,and a scraper chain speed of 0.66 m/s,while the machine running speed was maintained at 1 m/s.At the moment,the hand-over lifting structure exhibited a loss rate of 1.12%and a tuber injury rate of 0.94%.The conclusions obtained serve as a valuable reference for future research and optimization of sweet potato combines.展开更多
This research proposes an artificial neural network(ANN)-based repair and maintenance(R&M)cost estimation model for agricultural machinery.The proposed ANN model can achieve high estimation accuracy with small dat...This research proposes an artificial neural network(ANN)-based repair and maintenance(R&M)cost estimation model for agricultural machinery.The proposed ANN model can achieve high estimation accuracy with small data requirement.In the study,the proposed ANN model is implemented to estimate the R&M costs using a sample of locally-made rice combine harvesters.The model inputs are geographical regions,harvest area,and curve fitting coefficients related to historical cost data;and the ANN output is the estimated R&M cost.Multilayer feed-forward is adopted as the processing algorithm and Levenberg-Marquardt backpropagation learning as the training algorithm.The R&M costs are estimated using the ANN-based model,and results are compared with those of conventional mathematical estimation model.The results reveal that the percentage error between the conventional and ANN-based estimation models is below 1%,indicating the proposed ANN model’s high predictive accuracy.The proposed ANN-based model is useful for setting the service rates of agricultural machinery,given the significance of R&M cost in profitability.The novelty of this research lies in the use of curve-fitting coefficients in the ANN-based estimation model to improve estimation accuracy.Besides,the proposed ANN model could be further developed into web-based applications using a programming language to enable ease of use and greater user accessibility.Moreover,with minor modifications,the ANN estimation model is also applicable to other geographical areas and tractors or combine harvesters of different countries of origin.展开更多
Farmers have to finish their harvesting with high efficiency,because of time and cost.However,farmers are lacking knowledge and information required for selecting suitable combine harvesters and giving the conditions ...Farmers have to finish their harvesting with high efficiency,because of time and cost.However,farmers are lacking knowledge and information required for selecting suitable combine harvesters and giving the conditions of their rice fields,because both information factors(combine harvester and field condition)impact the field capacity.The field capacity model was generated from combine harvesters with the Thai Hom Mali rice variety(KDML-105).Therefore,this study aimed to determine the prediction model for effective field capacity to combine harvesters when harvesting the Thai Hom Mali rice variety(KDML-105).The methods began by collecting data of 15 combine harvesters,such as field,crop,and machine conditions and operating times;to generate the prediction model for the KDML-105 variety.The prediction model was then validated using 12 combine harvesters that were collected similarly to the model creation.The results showed a root mean square error(RMSE)of 0.24 m^(2)/s for the model.The prediction model can be applied for farmers to select the proper combine harvesters and give their field conditions.展开更多
A nonlinear dynamic simulation model based on coordinated control of speed and flow rate for the molten salt reactor and combined cycle systems is proposed here to ensure the coordination and stability between the mol...A nonlinear dynamic simulation model based on coordinated control of speed and flow rate for the molten salt reactor and combined cycle systems is proposed here to ensure the coordination and stability between the molten salt reactor and power system.This model considers the impact of thermal properties of fluid variation on accuracy and has been validated with Simulink.This study reveals the capability of the control system to compensate for anomalous situations and maintain shaft stability in the event of perturbations occurring in high-temperature molten salt tank outlet parameters.Meanwhile,the control system’s impact on the system’s dynamic characteristics under molten salt disturbance is also analyzed.The results reveal that after the disturbance occurs,the controlled system benefits from the action of the control,and the overshoot and disturbance amplitude are positively correlated,while the system power and frequency eventually return to the initial values.This simulation model provides a basis for utilizing molten salt reactors for power generation and maintaining grid stability.展开更多
Effective monitoring of the structural health of combined coal-rock under complex geological conditions by pressure stimulated currents(PSCs)has great potential for the understanding of dynamic disasters in undergroun...Effective monitoring of the structural health of combined coal-rock under complex geological conditions by pressure stimulated currents(PSCs)has great potential for the understanding of dynamic disasters in underground engineering.To reveal the effect of this way,the uniaxial compression experiments with PSC monitoring were conducted on three types of coal-rock combination samples with different strength combinations.The mechanism explanation of PSCs are investigated by resistivity test,atomic force microscopy(AFM)and computed tomography(CT)methods,and a PSC flow model based on progressive failure process is proposed.The influence of strength combinations on PSCs in the progressive failure process are emphasized.The results show the PSC responses between rock part,coal part and the two components are different,which are affected by multi-scale fracture characteristics and electrical properties.As the rock strength decreases,the progressive failure process changes obviously with the influence range of interface constraint effect decreasing,resulting in the different responses of PSC strength and direction in different parts to fracture behaviors.The PSC flow model is initially validated by the relationship between the accumulated charges of different parts.The results are expected to provide a new reference and method for mining design and roadway quality assessment.展开更多
Natural gas hydrate(NGH)is generally produced and accumulated together with the underlying conventional gas.Therefore,optimizing the production technology of these two gases should be seen as a relevant way to effecti...Natural gas hydrate(NGH)is generally produced and accumulated together with the underlying conventional gas.Therefore,optimizing the production technology of these two gases should be seen as a relevant way to effectively reduce the exploitation cost of the gas hydrate.In this study,three types of models accounting for the coexistence of these gases are considered.Type A considers the upper hydrate-bearing layer(HBL)adjacent to the lower conventional gas layer(CGL);with the Type B a permeable interlayer exists between the upper HBL and the lower CGL;with the type C there is an impermeable interlayer between the upper HBL and the lower CGL.The production performances associated with the above three models are calculated under different conditions,including only a depressurized HBL(only HBL DP);only a depressurized CGL(only CGL DP);and both the HBL and the CGL being depressurized(HBL+CGL DP).The results show that for Type A and Type B coexistence accumulation models,when only HBL or CGL is depressurized,the gas from the other layer will flow into the production layer due to the pressure difference between the two layers.In the coexistence accumulation model of type C,the cumulative gas production is much lower than that of Type A and Type B,regardless of whether only HBL DP,only CGL DP,or HBL+CGL DP are considered.This indicates that the impermeable interlayer restricts the cross-flow of gas between HBL and CGL.For three different coexistence accumulation models,CGL DP has the largest gas-to-water ratio.展开更多
Objective Combination immunotherapy strategies targeting OX40,a co-stimulatory molecule that can enhance antitumor immunity by modulating the proliferation,differentiation,and effector function of tumor-infiltrating T...Objective Combination immunotherapy strategies targeting OX40,a co-stimulatory molecule that can enhance antitumor immunity by modulating the proliferation,differentiation,and effector function of tumor-infiltrating T cells,have attracted much attention for their excellent therapeutic effects.In this study,we aimed to evaluate the antitumor efficacy of combined anti-OX40 and hepatitis B core viruslike particles(HBc VLPs)therapy using a mouse colon cancer model.Methods Humanized B-h OX40 mice were injected subcutaneously with MC38 colon tumor cells and treated with HBc VLPs+anti-h OX40 antibody.Tumor growth was monitored.Flow cytometric analysis was performed to evaluate the populations of T cell subsets in the tumors.Results The combination of anti-OX40 with HBc VLPs resulted in a significant delay in tumor growth,suggesting that a potent antitumor immunity was induced by the combination therapy.Further studies revealed that HBc VLPs+anti-OX40 treatment induced a significant increase in effector T cells(Teffs)and a significant decrease in regulatory T cells(Tregs)in the tumor microenvironment(TME),which accounted for the synergistic antitumor effect of anti-OX40 in combination with HBc VLPs.Conclusion Combination therapy of anti-h OX40 and HBc VLPs provides synergistic antitumor activity in colon cancer-bearing mice,which may represent a potential design strategy for cancer immunotherapy.展开更多
We propose a combined shape and topology optimization approach in this research for 3D acoustics by using the isogeometric boundary element method with subdivision surfaces.The existing structural optimization methods...We propose a combined shape and topology optimization approach in this research for 3D acoustics by using the isogeometric boundary element method with subdivision surfaces.The existing structural optimization methods mainly contain shape and topology schemes,with the former changing the surface geometric profile of the structure and the latter changing thematerial distribution topology or hole topology of the structure.In the present acoustic performance optimization,the coordinates of the control points in the subdivision surfaces fine mesh are selected as the shape design parameters of the structure,the artificial density of the sound absorbing material covered on the structure surface is set as the topology design parameter,and the combined topology and shape optimization approach is established through the sound field analysis of the subdivision surfaces boundary element method as a bridge.The topology and shape sensitivities of the approach are calculated using the adjoint variable method,which ensures the efficiency of the optimization.The geometric jaggedness and material distribution discontinuities that appear in the optimization process are overcome to a certain degree by the multiresolution method and solid isotropic material with penalization.Numerical examples are given to validate the effectiveness of the presented optimization approach.展开更多
BACKGROUND Recently,combination therapy has shown a better trend towards improved tumour response and survival outcomes than monotherapy in patients with hepatocellular carcinoma(HCC).However,research on triple therap...BACKGROUND Recently,combination therapy has shown a better trend towards improved tumour response and survival outcomes than monotherapy in patients with hepatocellular carcinoma(HCC).However,research on triple therapy[lenvatinib+sintilimab+transarterial chemoembolization(TACE)]as a first-line treatment for advanced HCC is limited.AIM To evaluate the safety and efficacy of triple therapy as a first-line treatment for advanced HCC.METHODS HCC patients with Barcelona Clinic Liver Cancer stage C treated with triple therapy were enrolled.All patients were treated with lenvatinib every day and sintilimab once every 3 wk.Moreover,TACE was performed every 4-6 wk if necessary.The primary outcome of the study was overall survival(OS).The secondary outcomes were the objective response rate(ORR),disease control rate(DCR),and incidence of adverse events.RESULTS Forty HCC patients who underwent triple therapy were retrospectively analysed from January 2019 to January 2022.With a median follow-up of 8.5 months,the 3-,6-,and 12-mo OS rates were 100%,88.5%,and 22.5%,respectively.The ORR and DCR were 45%and 90%,respectively.The median progressive free survival and median OS were not reached.Common complications were observed in 76%of the patients(grade 3,15%;grade 4,2.5%).CONCLUSION Combination therapy comprising lenvatinib,sintilimab and TACE achieved promising outcomes in advanced HCC patients and had manageable effects.展开更多
Simultaneous stresses of salinity and drought often coincide during rice-growing seasons in saline lands,primarily due to insufficient water resources and inadequate irrigation facilities.Consequently,combined salinit...Simultaneous stresses of salinity and drought often coincide during rice-growing seasons in saline lands,primarily due to insufficient water resources and inadequate irrigation facilities.Consequently,combined salinity-drought stress poses a major threat to rice production.In this study,two salinity levels(NS,non-salinity;HS,high salinity)along with three drought treatments(CC,control condition;DJ,drought stress imposed at jointing;DH,drought stress imposed at heading)were performed to investigate their combined influences on leaf photosynthetic characteristics,biomass accumulation,and rice yield formation.Salinity,drought,and their combination led to a shortened growth period from heading to maturity,resulting in a reduced overall growth duration.Grain yield was reduced under both salinity and drought stress,with a more substantial reduction under the combined salinity-drought stress.The combined stress imposed at heading caused greater yield losses in rice compared with the stress imposed at jointing.Additionally,the combined salinity-drought stress induced greater decreases in shoot biomass accumulation from heading to maturity,as well as in shoot biomass and nonstructural carbohydrate(NSC)content in the stem at heading and maturity.However,it increased the harvest index and NSC remobilization reserve.Salinity and drought reduced the leaf area index and SPAD value of flag leaves and weakened the leaf photosynthetic characteristics as indicated by lower photosynthetic rates,transpiration rates,and stomatal conductance.These reductions were more pronounced under the combined stress.Salinity,drought,and especially their combination,decreased the activities of ascorbate peroxidase,catalase,and superoxide dismutase,while increasing the contents of malondialdehyde,hydrogen peroxide,and superoxide radical.Our results indicated a more significant yield loss in rice when subjected to combined salinity-drought stress.The individual and combined stresses of salinity and drought diminished antioxidant enzyme activities,inhibited leaf photosynthetic functions,accelerated leaf senescence,and subsequently lowered assimilate accumulation and grain yield.展开更多
Objective: To explore the clinical effectiveness of combined use of intravenous pain pump with Parecoxib injection in alleviating pain in patients during the early postoperative period after thoracoscopic surgery. Met...Objective: To explore the clinical effectiveness of combined use of intravenous pain pump with Parecoxib injection in alleviating pain in patients during the early postoperative period after thoracoscopic surgery. Methods: Eighty patients who underwent thoracoscopic surgery in a tertiary hospital were selected as the study subjects and randomly divided into two groups, with 40 patients in each group. The control group received routine postoperative treatment with intravenous pain pump, while the experimental group received Parecoxib in addition to the standard postoperative pain pump treatment. Visual Analog Scale (VAS) pain scores were used to evaluate postoperative pain relief in both groups, along with adverse reactions, postoperative complications, and patient satisfaction with pain relief. Results: Patients who received Parecoxib injection in addition to the routine use of intravenous pain pump had VAS pain scores lower than 3 points at 6 h, 12 h, 24 h, and 36 h postoperatively compared to those in the control group. The incidence of postoperative lung collapse, pleural effusion, and pulmonary infections was also significantly lower in the experimental group. The differences between the two groups were statistically significant (P Conclusion: Early combined use of Parecoxib injection in the early postoperative period after thoracoscopic surgery has shown good clinical efficacy. It can reduce the level of pain in patients, promote effective coughing and expectoration, facilitate early mobilization of patients, improve patient compliance, reduce complications, shorten hospital stay, and expedite patient recovery. Therefore, it is worth promoting the widespread clinical application of Parecoxib injection in this setting.展开更多
In the present study,we investigated the synergistic effects of targeted methotrexate-selenium nanostructure containing Myc decoy oligodeoxynucleotides along with X-irradiation exposure as a combination therapy on LNC...In the present study,we investigated the synergistic effects of targeted methotrexate-selenium nanostructure containing Myc decoy oligodeoxynucleotides along with X-irradiation exposure as a combination therapy on LNCaP prostate cancer cells.Myc decoy ODNs were designed based on the promoter of Bcl-2 gene and analyzed by molecular docking and molecular dynamics assays.ODNs were loaded on the synthesized Se@BSA@Chi-MTX nanostructure.The physicochemical characteristics of nanostructures were determined by FTIR,DLS,UV-vis,TEM,EDX,in vitro release,and hemolysis tests.Subsequently,the cytotoxicity properties of them with and without X-irradiation were investigated by uptake,MTT,cell cycle,apoptosis,and scratch assays on the LNCaP cell line.The results of DLS and TEM showed negative charge(−9 mV)and nanometer size(40 nm)for Se@BSA@Chi-DEC-MTX NPs,respectively.The results of FTIR,UV-vis,and EDX showed the proper interaction of different parts and the correct synthesis of nanoparticles.The results of hemolysis showed the hemocompatibility of this nanoparticle in concentrations less than 6 mg/mL.The ODNs release from the nanostructures showed a pH-dependent manner,and the release rate was 15%higher in acidic pH.The targeted Se@BSA@Chi-labeled ODN-MTX NPs were efficiently taken up by LNCaP cells by targeting the prostate-specific membrane antigen(PSMA).The significant synergistic effects of nanostructure(containing MTX drug)treatment along with X-irradiation showed cell growth inhibition,apoptosis induction(~57%),cell cycle arrest(G2/M phase),and migration inhibition(up to 90%)compared to the control.The results suggested that the Se@BSA@Chi-DEC-MTX NPs can potentially suppress the cell growth of LNCaP cells.This nanostructure system can be a promising approach for targeted drug delivery and chemoradiotherapy in prostate cancer treatment.展开更多
To effectively quantify the impact of distributed photovoltaic(PV)access on the distribution network,this paper proposes a comprehensive evaluation method of distributed PV grid connection combining subjective and obj...To effectively quantify the impact of distributed photovoltaic(PV)access on the distribution network,this paper proposes a comprehensive evaluation method of distributed PV grid connection combining subjective and objective combination of assignment and technique for order preference by similarity to an ideal solution(TOPSIS)—rank sum ratio(RSR)(TOPSIS-RSR)method.Based on the traditional distribution network evaluation system,a comprehensive evaluation system has been constructed.It fully considers the new development requirements of distributed PV access on the environmental friendliness and absorptive capacity of the distribution grid and comprehensively reflects the impact of distributed PV grid connection.The analytic hierarchy process(AHP)was used to determine the subjective weights of the primary indicators,and the Spearman consistency test was combined to determine the weights of the secondary indicators based on three objective assignment methods.The subjective and objective combination weights of each assessment indicator were calculated through the principle of minimum entropy.Calculate the distance between the indicators to be evaluated and the positive and negative ideal solutions,the relative closeness ranking,and qualitative binning by TOPSIS-RSR method to obtain the comprehensive evaluation results of different scenarios.By setting up different PV grid-connected scenarios and utilizing the IEEE33 node simulation algorithm,the correctness and effectiveness of the proposed subject-object combination assignment and integrated assessment method are verified.展开更多
BACKGROUND There are very few cases of cardiac occluder detachment,and it is rare to completely remove the occluder using interventional methods without undergoing thoracotomy surgery after detachment.This case innova...BACKGROUND There are very few cases of cardiac occluder detachment,and it is rare to completely remove the occluder using interventional methods without undergoing thoracotomy surgery after detachment.This case innovatively used ultrasound guidance combined with digital subtraction angiography(DSA)to completely remove the occluder,accumulating some experience.CASE SUMMARY The patient underwent left atrial appendage occlusion surgery in our hospital due to atrial fibrillation.After the surgery,the occluder fell off and became free in the left ventricle,which is very dangerous.We innovatively used ultrasound guidance,combined with DSA,and interventional surgery to successfully capture the free occluder using a catcher,completely remove it,and then re implant a new left atrial appendage occluder.After the surgery,the patient recovered very well.CONCLUSION The size selection of the occluder is slightly conservative,and the shape of the left atrial appendage opening is irregular.展开更多
Precise and timely prediction of crop yields is crucial for food security and the development of agricultural policies.However,crop yield is influenced by multiple factors within complex growth environments.Previous r...Precise and timely prediction of crop yields is crucial for food security and the development of agricultural policies.However,crop yield is influenced by multiple factors within complex growth environments.Previous research has paid relatively little attention to the interference of environmental factors and drought on the growth of winter wheat.Therefore,there is an urgent need for more effective methods to explore the inherent relationship between these factors and crop yield,making precise yield prediction increasingly important.This study was based on four type of indicators including meteorological,crop growth status,environmental,and drought index,from October 2003 to June 2019 in Henan Province as the basic data for predicting winter wheat yield.Using the sparrow search al-gorithm combined with random forest(SSA-RF)under different input indicators,accuracy of winter wheat yield estimation was calcu-lated.The estimation accuracy of SSA-RF was compared with partial least squares regression(PLSR),extreme gradient boosting(XG-Boost),and random forest(RF)models.Finally,the determined optimal yield estimation method was used to predict winter wheat yield in three typical years.Following are the findings:1)the SSA-RF demonstrates superior performance in estimating winter wheat yield compared to other algorithms.The best yield estimation method is achieved by four types indicators’composition with SSA-RF)(R^(2)=0.805,RRMSE=9.9%.2)Crops growth status and environmental indicators play significant roles in wheat yield estimation,accounting for 46%and 22%of the yield importance among all indicators,respectively.3)Selecting indicators from October to April of the follow-ing year yielded the highest accuracy in winter wheat yield estimation,with an R^(2)of 0.826 and an RMSE of 9.0%.Yield estimates can be completed two months before the winter wheat harvest in June.4)The predicted performance will be slightly affected by severe drought.Compared with severe drought year(2011)(R^(2)=0.680)and normal year(2017)(R^(2)=0.790),the SSA-RF model has higher prediction accuracy for wet year(2018)(R^(2)=0.820).This study could provide an innovative approach for remote sensing estimation of winter wheat yield.yield.展开更多
文摘Agricultural mechanization plays a pivotal role in the transition from subsistence to commercial agriculture, with a particular focus on labour-intensive activities like harvesting. This study assesses the operational characteristics of the BRRI Whole Feed Combine Harvester (Model BRRI WCH2021) at the field level. Developed under the SFMRA project, the harvester’s technical performance and loss assessment were conducted during the Boro 2022 and Aman 2022 seasons in farmer fields in Bangladesh’s Rangpur region. The field efficiency of the harvester was determined to be 62.5% and 57.9% in the Boro and Aman seasons, respectively. Fuel consumption rates were recorded at 2.77 l/ha and 2.31 l/ha for the Boro and Aman seasons. The total harvesting losses, encompassing cutter bar, shatter, cylinder, and separation loss, averaged 0.56% and 0.48% in the Boro and Aman seasons, respectively. Mechanized harvesting with the BRRI Whole Feed Combine Harvester significantly reduced paddy losses by 5.81% compared to manual methods. The field evaluation results indicate the combine harvester’s satisfactory performance, highlighting its potential to alleviate labour demands during peak harvesting. The development of the BRRI WCH offers a sustainable solution for rice harvesting mechanization among progressive farmers. It paves the way for the broader adoption of advanced agricultural technology in Bangladesh.
文摘A study was conducted at PAU Regional Research Station, Gurdaspur (Punjab) to investigate the design and operational parameters of threshing mechanism of conventional combine harvester for basmati crop. This study was aimed to investigate the suitable changes required in the self-propelled conventional combine harvester for harvesting the basmati crop with minimum grain losses. Field evaluation of experiment was carried out to assess the influence of independent design variable <em>i.e.</em>, arrangement of spikes (AS) and independent operational parameters such as concave clearance (CC) and cylinder speed (CS). The study was aimed to enumerate various combining losses<em> viz</em>., extent of visible and invisible grain damage and threshing efficiency at different AS, CC and CS levels. The first year data recorded during 2017 were processed for the optimization during 2018. The results of the present study revealed that during 2017, maximum visible and invisible losses was 5.49% ± 0.33% and 28.07% ± 3.21%, respectively whereas after modification, these losses remained only 4.00% ± 0.80% and 24.07% ± 2.86%, respectively. The threshing efficiency remained above 99.31% ± 0.47%, for both years. Thus, optimization of combine harvester was able to save the visible grain damage by 60% to 83% and invisible grain damage by 6% to 16%, respectively during 2018 than the year 2017.
文摘Bangladesh, a country with 87% of rural households that depend on agriculture and rice dominated diets (70%), engages the country’s food security. Therefore, there is strong advocacy for a mechanized paddy harvesting system for food security in South Asia, mainly Bangladesh. Some harvesting machinery is available;however, the precise roles of a combine harvester during this process are little. This study attempts to understand the consequences of combining harvesters for paddy harvesting and compare them with hand harvesting. For comparison of field performance of combine harvester with traditional harvesting, the experiment was conducted at Gazipur District, Bangladesh, in 2016. Results showed that the labor required for harvesting unit area 283, 15 and 9.87 man-h∙ha<sup>−1</sup> for T<sub>1</sub> (Sickle + Head carry + Beating + Kula), T<sub>2</sub> (Reaper + Trolley carry + Close drum thresher + winnower), T<sub>3</sub> (Combine harvester) system, respectively. Likewise, the harvesting costs were 1.84 (T<sub>2</sub>) and 2.5 (T<sub>1</sub>) times higher than the combine harvester (T<sub>3</sub>). Also, the postharvest loss can be saved 1.84%, to use combine harvester over manual harvesting of paddy. The above result revealed that the semi-mechanized and mechanized harvesting system is a time, labor and cost-saving system;however, the manual reaping system is concerned with more postharvest losses (3.09%). This study highlights the importance of combine harvester;however, further research is required in other places with large and mini-combine harvesters under diverse cropping areas and to test a combine harvester’s detailed potentiality.
基金supported by the National Natural Science Foundation of China(Grant No.52105263)the Key Laboratory of Intelligent Equipment and Robotics for Agriculture of Zhejiang Province(Grant No.2022ZJZD2201).
文摘To improve the automation level and operation quality of China's beet harvester and reduce the loss due to damaged and missed excavation,this study used a self-developed sugar beet combine harvester and field simulation experiment platform,based on the single-factor bench test of the automatic row following system in the early stage,taking hydraulic flow A,spring preload B,and forward speed C which have significant influence on performance indices as test factors,and taking the missed excavation rate,breakage rate and reaction time as performance indices,the orthogonal experimental study on the parameter optimization of the three-factor and three-level automatic row following system with the first-order interaction of various factors was carried out.The results of the orthogonal experiments were analyzed using range analysis and variance analysis.The results showed that there were differences in the influence degree,factor priority order and first-order interaction,and the optimal parameter combination on each performance index.A weighted comprehensive scoring method was used to optimize and analyze each index.The optimal parameter combination of the overall operating performance of the automatic row following system was A 2B 2C 1,that is,the hydraulic flow was 25 L/min,the forward speed was 0.8 m/s,and the spring preload was 198 N.Under this combination,the response time was 0.496 s,the missed excavation rate was 2.35%,the breakage rate was 3.65%,and the operation quality was relatively good,which can meet the harvest requirements.The comprehensive optimization results were verified by field experiments with different ridge shapes and different planting patterns.The results showed that the mean values of the missed excavation rate of different planting patterns of conventional straight ridges and extremely large"S"ridges were 2.23%and 2.69%,respectively,and the maximum values were 2.39%and 2.98%,respectively;the average damage rates were 3.38%and 4.14%,and the maximum values were 3.58%and 4.48%,which meet the industry standards of sugar beet harvester operation quality.The overall adaptability of the automatic row following system is good.This study can provide a reference for research on automatic row following harvesting systems of sugar beets and other subsoil crop harvesters.
基金supported by the National Natural Science Foundation of China(Grant No.52205270 and 52075210)the China Postdoctoral Science Foundation(Grant No.2020M682438)China Agriculture Research System of MOF and MARA(Grant No.CARS-12).
文摘Existing development for cyclone separation cleaning components of the rapeseed combine harvester,which employs the suspending airflow to separate the rapeseeds from the materials other than grain(MOG),has the challenge to figure out the optimal working parameters,highlighting a need for exploration of the invisible airflow based on Computational Fluid Dynamics(CFD).The airflow status was mainly affected by the air velocities of the inlet,and the outlet for the MOG.The single factor and response surface experiments were carried out.It could be found that the inlet and MOG outlet velocities affected the air velocities through the change in the air quantity.Furthermore,the mathematical model of the relationship between the air velocities inside the cyclone and the working parameters was built,and the optimal combination of working parameters was obtained by multi-objective optimization.The inlet and outlet velocities of the optimal combination were 4.25 m/s and 29.87 m/s,respectively.Under this condition,the cleaning ratio and loss ratio of the cleaning device was 94.62%and 5.39%,respectively,as validated by the field experiment.The findings provide references for the improvement of cleaning systems for rapeseed combine harvesters.
基金supported by the Nanjing Agricultural Machinery Equipment Industry Intellectual Property Operation Center(04 City 2202-01)the Natural Science Foundation of Jiangsu Province(BK20201124)the earmarked fund for CARS-10-Sweetpotato,the innovation project of the Chinese Academy of Agricultural Sciences(31-NIAM-02).
文摘In order to meet the challenge of high loss rate and high tuber injury rate during the operation of the 4UZL-1 sweet potato combine harvester,the sweet potato tuber hand-over lifting mechanism was designed based on a comprehensive analysis of the entire structure of the harvester.Taking the average normal force on conveying sweet potato tubers as evaluation indexes,the EDEM simulation experiment was carried out considering the factors of the angle of the excavating and conveying mechanism,the conveying angle of the scraper chain,the speed of the excavating and conveying mechanism,and the speed of the scraper chain conveying.The experimental findings indicated that the optimal operational performance of the hand-over lifting mechanism was achieved at a speed of 1.15 m/s for the excavating and conveying mechanism,an angle of 24°for the excavating and conveying mechanism,a conveying speed of 0.66 m/s for the scraper chain,and a conveying angle of 60°for the scraper chain.Field experiments were conducted based on the EDEM simulation experiment,using the loss rate and the injury rate of conveying sweet potato tubers as evaluation indexes.The results showed that the hand-over lifting mechanism demonstrated optimal operational effectiveness with an excavating and conveying mechanism angle of 20°,a scraper chain angle of 68°,an excavating and conveying mechanism speed of 1.2 m/s,and a scraper chain speed of 0.66 m/s,while the machine running speed was maintained at 1 m/s.At the moment,the hand-over lifting structure exhibited a loss rate of 1.12%and a tuber injury rate of 0.94%.The conclusions obtained serve as a valuable reference for future research and optimization of sweet potato combines.
基金supported by the Fundamental Fund of Khon Kaen University(KKU).
文摘This research proposes an artificial neural network(ANN)-based repair and maintenance(R&M)cost estimation model for agricultural machinery.The proposed ANN model can achieve high estimation accuracy with small data requirement.In the study,the proposed ANN model is implemented to estimate the R&M costs using a sample of locally-made rice combine harvesters.The model inputs are geographical regions,harvest area,and curve fitting coefficients related to historical cost data;and the ANN output is the estimated R&M cost.Multilayer feed-forward is adopted as the processing algorithm and Levenberg-Marquardt backpropagation learning as the training algorithm.The R&M costs are estimated using the ANN-based model,and results are compared with those of conventional mathematical estimation model.The results reveal that the percentage error between the conventional and ANN-based estimation models is below 1%,indicating the proposed ANN model’s high predictive accuracy.The proposed ANN-based model is useful for setting the service rates of agricultural machinery,given the significance of R&M cost in profitability.The novelty of this research lies in the use of curve-fitting coefficients in the ANN-based estimation model to improve estimation accuracy.Besides,the proposed ANN model could be further developed into web-based applications using a programming language to enable ease of use and greater user accessibility.Moreover,with minor modifications,the ANN estimation model is also applicable to other geographical areas and tractors or combine harvesters of different countries of origin.
文摘Farmers have to finish their harvesting with high efficiency,because of time and cost.However,farmers are lacking knowledge and information required for selecting suitable combine harvesters and giving the conditions of their rice fields,because both information factors(combine harvester and field condition)impact the field capacity.The field capacity model was generated from combine harvesters with the Thai Hom Mali rice variety(KDML-105).Therefore,this study aimed to determine the prediction model for effective field capacity to combine harvesters when harvesting the Thai Hom Mali rice variety(KDML-105).The methods began by collecting data of 15 combine harvesters,such as field,crop,and machine conditions and operating times;to generate the prediction model for the KDML-105 variety.The prediction model was then validated using 12 combine harvesters that were collected similarly to the model creation.The results showed a root mean square error(RMSE)of 0.24 m^(2)/s for the model.The prediction model can be applied for farmers to select the proper combine harvesters and give their field conditions.
基金This work was supported by the Chinese TMSR Strategic Pioneer Science and Technology Project(No.XDA02010300).
文摘A nonlinear dynamic simulation model based on coordinated control of speed and flow rate for the molten salt reactor and combined cycle systems is proposed here to ensure the coordination and stability between the molten salt reactor and power system.This model considers the impact of thermal properties of fluid variation on accuracy and has been validated with Simulink.This study reveals the capability of the control system to compensate for anomalous situations and maintain shaft stability in the event of perturbations occurring in high-temperature molten salt tank outlet parameters.Meanwhile,the control system’s impact on the system’s dynamic characteristics under molten salt disturbance is also analyzed.The results reveal that after the disturbance occurs,the controlled system benefits from the action of the control,and the overshoot and disturbance amplitude are positively correlated,while the system power and frequency eventually return to the initial values.This simulation model provides a basis for utilizing molten salt reactors for power generation and maintaining grid stability.
基金supported by National Key R&D Program of China(No.2022YFC3004705)the National Natural Science Foundation of China(Nos.52074280,52227901 and 52204249)National Natural Science Foundation of China Youth Fund(No.52104230).
文摘Effective monitoring of the structural health of combined coal-rock under complex geological conditions by pressure stimulated currents(PSCs)has great potential for the understanding of dynamic disasters in underground engineering.To reveal the effect of this way,the uniaxial compression experiments with PSC monitoring were conducted on three types of coal-rock combination samples with different strength combinations.The mechanism explanation of PSCs are investigated by resistivity test,atomic force microscopy(AFM)and computed tomography(CT)methods,and a PSC flow model based on progressive failure process is proposed.The influence of strength combinations on PSCs in the progressive failure process are emphasized.The results show the PSC responses between rock part,coal part and the two components are different,which are affected by multi-scale fracture characteristics and electrical properties.As the rock strength decreases,the progressive failure process changes obviously with the influence range of interface constraint effect decreasing,resulting in the different responses of PSC strength and direction in different parts to fracture behaviors.The PSC flow model is initially validated by the relationship between the accumulated charges of different parts.The results are expected to provide a new reference and method for mining design and roadway quality assessment.
基金supported by the National Natural Science Foundation of China (Nos.52074334,51991365)the National Key R&D Program of China (2021YFC2800903),which are gratefully acknowledged.
文摘Natural gas hydrate(NGH)is generally produced and accumulated together with the underlying conventional gas.Therefore,optimizing the production technology of these two gases should be seen as a relevant way to effectively reduce the exploitation cost of the gas hydrate.In this study,three types of models accounting for the coexistence of these gases are considered.Type A considers the upper hydrate-bearing layer(HBL)adjacent to the lower conventional gas layer(CGL);with the Type B a permeable interlayer exists between the upper HBL and the lower CGL;with the type C there is an impermeable interlayer between the upper HBL and the lower CGL.The production performances associated with the above three models are calculated under different conditions,including only a depressurized HBL(only HBL DP);only a depressurized CGL(only CGL DP);and both the HBL and the CGL being depressurized(HBL+CGL DP).The results show that for Type A and Type B coexistence accumulation models,when only HBL or CGL is depressurized,the gas from the other layer will flow into the production layer due to the pressure difference between the two layers.In the coexistence accumulation model of type C,the cumulative gas production is much lower than that of Type A and Type B,regardless of whether only HBL DP,only CGL DP,or HBL+CGL DP are considered.This indicates that the impermeable interlayer restricts the cross-flow of gas between HBL and CGL.For three different coexistence accumulation models,CGL DP has the largest gas-to-water ratio.
基金supported by National Major Science and Technology Projects of China 2017ZX10105015-001-002。
文摘Objective Combination immunotherapy strategies targeting OX40,a co-stimulatory molecule that can enhance antitumor immunity by modulating the proliferation,differentiation,and effector function of tumor-infiltrating T cells,have attracted much attention for their excellent therapeutic effects.In this study,we aimed to evaluate the antitumor efficacy of combined anti-OX40 and hepatitis B core viruslike particles(HBc VLPs)therapy using a mouse colon cancer model.Methods Humanized B-h OX40 mice were injected subcutaneously with MC38 colon tumor cells and treated with HBc VLPs+anti-h OX40 antibody.Tumor growth was monitored.Flow cytometric analysis was performed to evaluate the populations of T cell subsets in the tumors.Results The combination of anti-OX40 with HBc VLPs resulted in a significant delay in tumor growth,suggesting that a potent antitumor immunity was induced by the combination therapy.Further studies revealed that HBc VLPs+anti-OX40 treatment induced a significant increase in effector T cells(Teffs)and a significant decrease in regulatory T cells(Tregs)in the tumor microenvironment(TME),which accounted for the synergistic antitumor effect of anti-OX40 in combination with HBc VLPs.Conclusion Combination therapy of anti-h OX40 and HBc VLPs provides synergistic antitumor activity in colon cancer-bearing mice,which may represent a potential design strategy for cancer immunotherapy.
基金supported by the National Natural Science Foundation of China (NSFC)under Grant Nos.12172350,11772322 and 11702238。
文摘We propose a combined shape and topology optimization approach in this research for 3D acoustics by using the isogeometric boundary element method with subdivision surfaces.The existing structural optimization methods mainly contain shape and topology schemes,with the former changing the surface geometric profile of the structure and the latter changing thematerial distribution topology or hole topology of the structure.In the present acoustic performance optimization,the coordinates of the control points in the subdivision surfaces fine mesh are selected as the shape design parameters of the structure,the artificial density of the sound absorbing material covered on the structure surface is set as the topology design parameter,and the combined topology and shape optimization approach is established through the sound field analysis of the subdivision surfaces boundary element method as a bridge.The topology and shape sensitivities of the approach are calculated using the adjoint variable method,which ensures the efficiency of the optimization.The geometric jaggedness and material distribution discontinuities that appear in the optimization process are overcome to a certain degree by the multiresolution method and solid isotropic material with penalization.Numerical examples are given to validate the effectiveness of the presented optimization approach.
基金Capital Health Development and Scientific Research Special Project,No.2022-2-2175.
文摘BACKGROUND Recently,combination therapy has shown a better trend towards improved tumour response and survival outcomes than monotherapy in patients with hepatocellular carcinoma(HCC).However,research on triple therapy[lenvatinib+sintilimab+transarterial chemoembolization(TACE)]as a first-line treatment for advanced HCC is limited.AIM To evaluate the safety and efficacy of triple therapy as a first-line treatment for advanced HCC.METHODS HCC patients with Barcelona Clinic Liver Cancer stage C treated with triple therapy were enrolled.All patients were treated with lenvatinib every day and sintilimab once every 3 wk.Moreover,TACE was performed every 4-6 wk if necessary.The primary outcome of the study was overall survival(OS).The secondary outcomes were the objective response rate(ORR),disease control rate(DCR),and incidence of adverse events.RESULTS Forty HCC patients who underwent triple therapy were retrospectively analysed from January 2019 to January 2022.With a median follow-up of 8.5 months,the 3-,6-,and 12-mo OS rates were 100%,88.5%,and 22.5%,respectively.The ORR and DCR were 45%and 90%,respectively.The median progressive free survival and median OS were not reached.Common complications were observed in 76%of the patients(grade 3,15%;grade 4,2.5%).CONCLUSION Combination therapy comprising lenvatinib,sintilimab and TACE achieved promising outcomes in advanced HCC patients and had manageable effects.
基金financed by the National Key Research and Development Program,China(Grant Nos.2022YFE0113400 and 2022YFD1500402)National Natural Science Foundation of China(Grant No.32001466)+3 种基金Scientific and Technological Innovation Fund of Carbon Emissions Peak and Neutrality of Jiangsu Provincial Department of Science and Technology,China(Grant Nos.BE2022304 and BE2022305)Joints Funds of the National Natural Science Foundation of China(Grant No.U20A2022)Postdoctoral Research Foundation of China(Grant No.2020M671628)the Priority Academic Program Development of Jiangsu Higher Education Institutions,China.
文摘Simultaneous stresses of salinity and drought often coincide during rice-growing seasons in saline lands,primarily due to insufficient water resources and inadequate irrigation facilities.Consequently,combined salinity-drought stress poses a major threat to rice production.In this study,two salinity levels(NS,non-salinity;HS,high salinity)along with three drought treatments(CC,control condition;DJ,drought stress imposed at jointing;DH,drought stress imposed at heading)were performed to investigate their combined influences on leaf photosynthetic characteristics,biomass accumulation,and rice yield formation.Salinity,drought,and their combination led to a shortened growth period from heading to maturity,resulting in a reduced overall growth duration.Grain yield was reduced under both salinity and drought stress,with a more substantial reduction under the combined salinity-drought stress.The combined stress imposed at heading caused greater yield losses in rice compared with the stress imposed at jointing.Additionally,the combined salinity-drought stress induced greater decreases in shoot biomass accumulation from heading to maturity,as well as in shoot biomass and nonstructural carbohydrate(NSC)content in the stem at heading and maturity.However,it increased the harvest index and NSC remobilization reserve.Salinity and drought reduced the leaf area index and SPAD value of flag leaves and weakened the leaf photosynthetic characteristics as indicated by lower photosynthetic rates,transpiration rates,and stomatal conductance.These reductions were more pronounced under the combined stress.Salinity,drought,and especially their combination,decreased the activities of ascorbate peroxidase,catalase,and superoxide dismutase,while increasing the contents of malondialdehyde,hydrogen peroxide,and superoxide radical.Our results indicated a more significant yield loss in rice when subjected to combined salinity-drought stress.The individual and combined stresses of salinity and drought diminished antioxidant enzyme activities,inhibited leaf photosynthetic functions,accelerated leaf senescence,and subsequently lowered assimilate accumulation and grain yield.
文摘Objective: To explore the clinical effectiveness of combined use of intravenous pain pump with Parecoxib injection in alleviating pain in patients during the early postoperative period after thoracoscopic surgery. Methods: Eighty patients who underwent thoracoscopic surgery in a tertiary hospital were selected as the study subjects and randomly divided into two groups, with 40 patients in each group. The control group received routine postoperative treatment with intravenous pain pump, while the experimental group received Parecoxib in addition to the standard postoperative pain pump treatment. Visual Analog Scale (VAS) pain scores were used to evaluate postoperative pain relief in both groups, along with adverse reactions, postoperative complications, and patient satisfaction with pain relief. Results: Patients who received Parecoxib injection in addition to the routine use of intravenous pain pump had VAS pain scores lower than 3 points at 6 h, 12 h, 24 h, and 36 h postoperatively compared to those in the control group. The incidence of postoperative lung collapse, pleural effusion, and pulmonary infections was also significantly lower in the experimental group. The differences between the two groups were statistically significant (P Conclusion: Early combined use of Parecoxib injection in the early postoperative period after thoracoscopic surgery has shown good clinical efficacy. It can reduce the level of pain in patients, promote effective coughing and expectoration, facilitate early mobilization of patients, improve patient compliance, reduce complications, shorten hospital stay, and expedite patient recovery. Therefore, it is worth promoting the widespread clinical application of Parecoxib injection in this setting.
基金Zanjan University of Medical Sciences supported the present study(Grant Number:A-12-1244-18).
文摘In the present study,we investigated the synergistic effects of targeted methotrexate-selenium nanostructure containing Myc decoy oligodeoxynucleotides along with X-irradiation exposure as a combination therapy on LNCaP prostate cancer cells.Myc decoy ODNs were designed based on the promoter of Bcl-2 gene and analyzed by molecular docking and molecular dynamics assays.ODNs were loaded on the synthesized Se@BSA@Chi-MTX nanostructure.The physicochemical characteristics of nanostructures were determined by FTIR,DLS,UV-vis,TEM,EDX,in vitro release,and hemolysis tests.Subsequently,the cytotoxicity properties of them with and without X-irradiation were investigated by uptake,MTT,cell cycle,apoptosis,and scratch assays on the LNCaP cell line.The results of DLS and TEM showed negative charge(−9 mV)and nanometer size(40 nm)for Se@BSA@Chi-DEC-MTX NPs,respectively.The results of FTIR,UV-vis,and EDX showed the proper interaction of different parts and the correct synthesis of nanoparticles.The results of hemolysis showed the hemocompatibility of this nanoparticle in concentrations less than 6 mg/mL.The ODNs release from the nanostructures showed a pH-dependent manner,and the release rate was 15%higher in acidic pH.The targeted Se@BSA@Chi-labeled ODN-MTX NPs were efficiently taken up by LNCaP cells by targeting the prostate-specific membrane antigen(PSMA).The significant synergistic effects of nanostructure(containing MTX drug)treatment along with X-irradiation showed cell growth inhibition,apoptosis induction(~57%),cell cycle arrest(G2/M phase),and migration inhibition(up to 90%)compared to the control.The results suggested that the Se@BSA@Chi-DEC-MTX NPs can potentially suppress the cell growth of LNCaP cells.This nanostructure system can be a promising approach for targeted drug delivery and chemoradiotherapy in prostate cancer treatment.
基金support of the project“State Grid Corporation Headquarters Science and Technology Program(5108-202299258A-1-0-ZB)”.
文摘To effectively quantify the impact of distributed photovoltaic(PV)access on the distribution network,this paper proposes a comprehensive evaluation method of distributed PV grid connection combining subjective and objective combination of assignment and technique for order preference by similarity to an ideal solution(TOPSIS)—rank sum ratio(RSR)(TOPSIS-RSR)method.Based on the traditional distribution network evaluation system,a comprehensive evaluation system has been constructed.It fully considers the new development requirements of distributed PV access on the environmental friendliness and absorptive capacity of the distribution grid and comprehensively reflects the impact of distributed PV grid connection.The analytic hierarchy process(AHP)was used to determine the subjective weights of the primary indicators,and the Spearman consistency test was combined to determine the weights of the secondary indicators based on three objective assignment methods.The subjective and objective combination weights of each assessment indicator were calculated through the principle of minimum entropy.Calculate the distance between the indicators to be evaluated and the positive and negative ideal solutions,the relative closeness ranking,and qualitative binning by TOPSIS-RSR method to obtain the comprehensive evaluation results of different scenarios.By setting up different PV grid-connected scenarios and utilizing the IEEE33 node simulation algorithm,the correctness and effectiveness of the proposed subject-object combination assignment and integrated assessment method are verified.
文摘BACKGROUND There are very few cases of cardiac occluder detachment,and it is rare to completely remove the occluder using interventional methods without undergoing thoracotomy surgery after detachment.This case innovatively used ultrasound guidance combined with digital subtraction angiography(DSA)to completely remove the occluder,accumulating some experience.CASE SUMMARY The patient underwent left atrial appendage occlusion surgery in our hospital due to atrial fibrillation.After the surgery,the occluder fell off and became free in the left ventricle,which is very dangerous.We innovatively used ultrasound guidance,combined with DSA,and interventional surgery to successfully capture the free occluder using a catcher,completely remove it,and then re implant a new left atrial appendage occluder.After the surgery,the patient recovered very well.CONCLUSION The size selection of the occluder is slightly conservative,and the shape of the left atrial appendage opening is irregular.
基金Under the auspices of National Natural Science Foundation of China(No.52079103)。
文摘Precise and timely prediction of crop yields is crucial for food security and the development of agricultural policies.However,crop yield is influenced by multiple factors within complex growth environments.Previous research has paid relatively little attention to the interference of environmental factors and drought on the growth of winter wheat.Therefore,there is an urgent need for more effective methods to explore the inherent relationship between these factors and crop yield,making precise yield prediction increasingly important.This study was based on four type of indicators including meteorological,crop growth status,environmental,and drought index,from October 2003 to June 2019 in Henan Province as the basic data for predicting winter wheat yield.Using the sparrow search al-gorithm combined with random forest(SSA-RF)under different input indicators,accuracy of winter wheat yield estimation was calcu-lated.The estimation accuracy of SSA-RF was compared with partial least squares regression(PLSR),extreme gradient boosting(XG-Boost),and random forest(RF)models.Finally,the determined optimal yield estimation method was used to predict winter wheat yield in three typical years.Following are the findings:1)the SSA-RF demonstrates superior performance in estimating winter wheat yield compared to other algorithms.The best yield estimation method is achieved by four types indicators’composition with SSA-RF)(R^(2)=0.805,RRMSE=9.9%.2)Crops growth status and environmental indicators play significant roles in wheat yield estimation,accounting for 46%and 22%of the yield importance among all indicators,respectively.3)Selecting indicators from October to April of the follow-ing year yielded the highest accuracy in winter wheat yield estimation,with an R^(2)of 0.826 and an RMSE of 9.0%.Yield estimates can be completed two months before the winter wheat harvest in June.4)The predicted performance will be slightly affected by severe drought.Compared with severe drought year(2011)(R^(2)=0.680)and normal year(2017)(R^(2)=0.790),the SSA-RF model has higher prediction accuracy for wet year(2018)(R^(2)=0.820).This study could provide an innovative approach for remote sensing estimation of winter wheat yield.yield.
