Coronavirus disease 2019(COVID-19)is an emerging disease caused by the coronavirus,SARS-CoV-2,which leads to severe respiratory infections in humans.COVID-19 was first reported in December 2019 in Wuhan city,a populat...Coronavirus disease 2019(COVID-19)is an emerging disease caused by the coronavirus,SARS-CoV-2,which leads to severe respiratory infections in humans.COVID-19 was first reported in December 2019 in Wuhan city,a populated area of the Hubei province in China.As of now,Wuhan and other cities nearby have become safe places for locals.The rapid control of the spread of COVID-19 infection was made possible due to several interventions and measures that were undertaken in Wuhan.This narrative review study was designed to evaluate the emerging literature on the combined measures taken to control the COVID-19 pandemic in Wuhan city.Science Direct,Springer,Web of Science,and the PubMed data repositories were searched for studies published between December 1,2019,and June 07,2020.The referred“preferred reporting items for systematic reviews and meta-analyses”(PRISMA)protocol was used to conduct this narrative review.A total of 330 research studies were found as a result of the initial search based on exclusion and inclusion criteria,and 30 articles were chosen on final evaluation.It was discovered that the combined measures to control the spread of COVID-19 in Wuhan included cordon sanitaire,social distancing,universal symptom surveys,quarantine strategies,and transport restrictions.Based on the recommendations presented in this review study,existing policies with regard to combined measures and public health policies can be enforced by other countries to implement a rapid control procedure to control the spread of the COVID-19 pandemic.展开更多
BACKGROUND: Recent researches demonstrate that onset of cerebral infarction always accompanies with obvious changes of function of thyroid axis; while, high-homocysteic acidemia has been proved as one of risk factors ...BACKGROUND: Recent researches demonstrate that onset of cerebral infarction always accompanies with obvious changes of function of thyroid axis; while, high-homocysteic acidemia has been proved as one of risk factors of vascular dementia and Alzheimer disease. Meanwhile, it is found that level of plasma homocysteic acid is positive correlation with injured degrees of cognitive function and brain damage. OBJECTIVE: To observe the changes of function of thyroid and level of homocysteic acid among patients with vascular dementia and compare with those patients without dementia cerebral infarction. DESIGN: Randomized grouping and contrast observation. SETTING: Department of Neurology, People's Hospital Affiliated to Yunyang Medical College, South China Hospital of Wuhan University. PARTICIPANTS: A total of 38 patients with vascular dementia were hospitalized in the Department of Neurology, People's Hospital Affiliated to Yunyang Medical College from February 2004 to December 2005. All patients met the diagnostic criteria of the Fourth Edition of Diagnostic and Statistical Manual of Mental Disorder (DSM-IV) established by American Psychiatric Association. Based on educational degrees, Mini-mental Status Examination (MMSE) was classified into illiteracy (≤ 17 points), education of primary school (educational duration ≤ 6 years, ≤ 24 points) and education of middle school or above (educational duration > 6 years, ≤ 24 points). Forty patients with non-dementia cerebral infarction were regarded as the control group and checked with CT examination. There were no significant differences of sex and age between the two groups. All patients and relatives were provided the consent. METHODS: Within 24 hours after hospitalization, patients with vascular dementia received MMSE scores, and the degrees were classified based on the scoring results: mild (20-24 points), moderate (10-19 points) and severe (below 10 points). Levels of thyroxine were measured with radioimmunodetection and content of homocysteic acid was measured with high performance liquid chromatogram (HPLC) electrochemical detection. MAIN OUTCOME MEASURES: Levels of homocysteic acid and thyroxine among patients with vascular dementia and non-dementia cerebral infarction. RESULTS: A total of 38 patients with vascular dementia and 40 patients with non-dementia cerebral infarction were involved in the final analysis. ① Levels of triiodothyronine (T3), thyroxine (T4) and free T3 (FT3) were (0.9±0.4) μg/L, (92.9±26.4) μg/L and (3.9±1.8) pmol/L in vascular dementia group respectively, which were higher than those in control group [(1.3±0.3) μg/L, (110.2±28.7) μg/L, (7.2±2.1) pmol/L, t =2.766 6-7.433 6, P < 0.01]; while, level of homocysteic acid was (29.57±7.12) μmol/L in vascular dementia group, which was higher than that in control group [(24.53±4.98) μmol/L, t =3.637 7, P < 0.01]. There were no significant differences of free T4 (FT4) and thyrotropic-stimulating hormone (TSH) between the two groups (P > 0.05). ② Levels of FT3 of patients with mild, moderate and severe vascular dementia were (1.0±0.2), (0.9±0.1) and (0.8±0.1) μg/L, respectively; levels of homocysteic acid were (26.52±4.84), (29.59±5.56) and (32.71±6.17) μmol/L, respectively. There were significant differences among patients at the three degrees of vascular dementia (F =3.59-32.4, P < 0.01). However, there were no significant differences of T4, FT4 and TSH among the three kinds of patients (P > 0.05). CONCLUSION: Levels of thyroxine of patients with vascular dementia decrease; however, levels of homocysteic acid increase. Therefore, the results can indirectly reflect severities of vascular dementia.展开更多
The accurate measurement of surfaces of large aviation components is vital for the assessment of manufacturing and assembly quality of such components.To satisfy the measurement requirement of large-size components,mo...The accurate measurement of surfaces of large aviation components is vital for the assessment of manufacturing and assembly quality of such components.To satisfy the measurement requirement of large-size components,most current researches pay more attention to combined measurement methods utilizing different measuring instruments,but the related researches on error analysis and optimization methods are not taken enough attention.This paper proposes a combined laser-assisted measurement method with feature enhancement techniques,and it also develops an error propagation model of the main factors affecting the overall measurement error in detail.Firstly,the surface of a large-size component is measured by the measurement system at multiple stations.Secondly,a control point coordinate system is established as a bridge to unify all local measurement data into the global coordinate system.To improve the overall measurement accuracy,the pixel extraction error as a key factor causing the overall measurement error is analyzed in detail.Next,the error propagation model is established,and some optimization strategies of layout for minimizing measurement error and transformation error are researched.Finally,experiments are carried out to verify the effectiveness of the proposed method.The results show that the measurement error of the proposed method reaches 0.073%and 0.14%with a 1 D standard ruler and a flat plate,respectively.展开更多
文摘Coronavirus disease 2019(COVID-19)is an emerging disease caused by the coronavirus,SARS-CoV-2,which leads to severe respiratory infections in humans.COVID-19 was first reported in December 2019 in Wuhan city,a populated area of the Hubei province in China.As of now,Wuhan and other cities nearby have become safe places for locals.The rapid control of the spread of COVID-19 infection was made possible due to several interventions and measures that were undertaken in Wuhan.This narrative review study was designed to evaluate the emerging literature on the combined measures taken to control the COVID-19 pandemic in Wuhan city.Science Direct,Springer,Web of Science,and the PubMed data repositories were searched for studies published between December 1,2019,and June 07,2020.The referred“preferred reporting items for systematic reviews and meta-analyses”(PRISMA)protocol was used to conduct this narrative review.A total of 330 research studies were found as a result of the initial search based on exclusion and inclusion criteria,and 30 articles were chosen on final evaluation.It was discovered that the combined measures to control the spread of COVID-19 in Wuhan included cordon sanitaire,social distancing,universal symptom surveys,quarantine strategies,and transport restrictions.Based on the recommendations presented in this review study,existing policies with regard to combined measures and public health policies can be enforced by other countries to implement a rapid control procedure to control the spread of the COVID-19 pandemic.
文摘BACKGROUND: Recent researches demonstrate that onset of cerebral infarction always accompanies with obvious changes of function of thyroid axis; while, high-homocysteic acidemia has been proved as one of risk factors of vascular dementia and Alzheimer disease. Meanwhile, it is found that level of plasma homocysteic acid is positive correlation with injured degrees of cognitive function and brain damage. OBJECTIVE: To observe the changes of function of thyroid and level of homocysteic acid among patients with vascular dementia and compare with those patients without dementia cerebral infarction. DESIGN: Randomized grouping and contrast observation. SETTING: Department of Neurology, People's Hospital Affiliated to Yunyang Medical College, South China Hospital of Wuhan University. PARTICIPANTS: A total of 38 patients with vascular dementia were hospitalized in the Department of Neurology, People's Hospital Affiliated to Yunyang Medical College from February 2004 to December 2005. All patients met the diagnostic criteria of the Fourth Edition of Diagnostic and Statistical Manual of Mental Disorder (DSM-IV) established by American Psychiatric Association. Based on educational degrees, Mini-mental Status Examination (MMSE) was classified into illiteracy (≤ 17 points), education of primary school (educational duration ≤ 6 years, ≤ 24 points) and education of middle school or above (educational duration > 6 years, ≤ 24 points). Forty patients with non-dementia cerebral infarction were regarded as the control group and checked with CT examination. There were no significant differences of sex and age between the two groups. All patients and relatives were provided the consent. METHODS: Within 24 hours after hospitalization, patients with vascular dementia received MMSE scores, and the degrees were classified based on the scoring results: mild (20-24 points), moderate (10-19 points) and severe (below 10 points). Levels of thyroxine were measured with radioimmunodetection and content of homocysteic acid was measured with high performance liquid chromatogram (HPLC) electrochemical detection. MAIN OUTCOME MEASURES: Levels of homocysteic acid and thyroxine among patients with vascular dementia and non-dementia cerebral infarction. RESULTS: A total of 38 patients with vascular dementia and 40 patients with non-dementia cerebral infarction were involved in the final analysis. ① Levels of triiodothyronine (T3), thyroxine (T4) and free T3 (FT3) were (0.9±0.4) μg/L, (92.9±26.4) μg/L and (3.9±1.8) pmol/L in vascular dementia group respectively, which were higher than those in control group [(1.3±0.3) μg/L, (110.2±28.7) μg/L, (7.2±2.1) pmol/L, t =2.766 6-7.433 6, P < 0.01]; while, level of homocysteic acid was (29.57±7.12) μmol/L in vascular dementia group, which was higher than that in control group [(24.53±4.98) μmol/L, t =3.637 7, P < 0.01]. There were no significant differences of free T4 (FT4) and thyrotropic-stimulating hormone (TSH) between the two groups (P > 0.05). ② Levels of FT3 of patients with mild, moderate and severe vascular dementia were (1.0±0.2), (0.9±0.1) and (0.8±0.1) μg/L, respectively; levels of homocysteic acid were (26.52±4.84), (29.59±5.56) and (32.71±6.17) μmol/L, respectively. There were significant differences among patients at the three degrees of vascular dementia (F =3.59-32.4, P < 0.01). However, there were no significant differences of T4, FT4 and TSH among the three kinds of patients (P > 0.05). CONCLUSION: Levels of thyroxine of patients with vascular dementia decrease; however, levels of homocysteic acid increase. Therefore, the results can indirectly reflect severities of vascular dementia.
基金co-supported by the National Key Research and Development Project of China(No.2018YFA0703304)the High-level Personnel Innovation Support Program of Dalian(No.2017RJ04)+2 种基金Youth Program of National Natural Science Foundation of China(No.51905077)Liaoning Revitalization Talents Program(No.XLYC1807086)China Postdoctoral Science Foundation Grand(No.2019M651110)。
文摘The accurate measurement of surfaces of large aviation components is vital for the assessment of manufacturing and assembly quality of such components.To satisfy the measurement requirement of large-size components,most current researches pay more attention to combined measurement methods utilizing different measuring instruments,but the related researches on error analysis and optimization methods are not taken enough attention.This paper proposes a combined laser-assisted measurement method with feature enhancement techniques,and it also develops an error propagation model of the main factors affecting the overall measurement error in detail.Firstly,the surface of a large-size component is measured by the measurement system at multiple stations.Secondly,a control point coordinate system is established as a bridge to unify all local measurement data into the global coordinate system.To improve the overall measurement accuracy,the pixel extraction error as a key factor causing the overall measurement error is analyzed in detail.Next,the error propagation model is established,and some optimization strategies of layout for minimizing measurement error and transformation error are researched.Finally,experiments are carried out to verify the effectiveness of the proposed method.The results show that the measurement error of the proposed method reaches 0.073%and 0.14%with a 1 D standard ruler and a flat plate,respectively.
