The increasing demand for industrial automation and intelligence has put forward higher requirements for the reliability of industrial wireless communication technology.As an international standard based on 802.11,Wir...The increasing demand for industrial automation and intelligence has put forward higher requirements for the reliability of industrial wireless communication technology.As an international standard based on 802.11,Wireless networks for Industrial Automation-Factory Automation(WIA-FA)greatly improves the reliability in factory automation scenarios by Time Division Multiple Access(TDMA).However,in ultra-dense WIA-FA networks with mobile users,the basic connection management mechanism is inefficient.Most of the handover and resource management algorithms are all based on frequency division multiplexing,not suitable for the TDMA in the WIA-FA network.Therefore,we propose Load-aware Connection Management(LACM)algorithm to adjust the linkage and balance the load of access devices to avoid blocking and improve the reliability of the system.And then we simulate the algorithm to find the optimal settings of the parameters.After comparing with other existing algorithms,the result of the simulation proves that LACM is more efficient in reliability and maintains high reliability of more than 99.8%even in the ultra-dense moving scenario with 1500 field devices.Besides,this algorithm ensures that only a few signaling exchanges are required to ensure load bal-ancing,which is no more than 5 times,and less than half of the best state-of-the-art algorithm.展开更多
Seismic fragility analysis of three-tower cable-stayed bridges with three different structural systems,including rigid system(RS),floating system(FS),and passive energy dissipation system(PEDS),is conducted to study t...Seismic fragility analysis of three-tower cable-stayed bridges with three different structural systems,including rigid system(RS),floating system(FS),and passive energy dissipation system(PEDS),is conducted to study the effects of connection configurations on seismic responses and fragilities.Finite element models of bridges are established using OpenSees.A new ground motion screening method based on the statistical characteristic of the predominant period is proposed to avoid irregular behavior in the selection process of ground motions,and incremental dynamic analysis(IDA)is performed to develop components and systems fragility curves.The effects of damper failure on calculated results for PEDS are examined in terms of seismic response and fragility analysis.The results show that the bridge tower is the most affected component by different structural systems.For RS,the fragility of the middle tower is significantly higher than other components,and the bridge failure starts from the middle tower,exhibiting a characteristic of local failure.For FS and PEDS,the fragility of the edge tower is higher than the middle tower.The system fragility of RS is higher than FS and PEDS.Taking the failure of dampers into account is necessary to obtain reliable seismic capacity of cable-stayed bridges.展开更多
The synchronous virtual machine uses inverter power to imitate the performance of the conventional synchronous machine.It also has the same inertia,damping,frequency,voltage regulation,and other external performance a...The synchronous virtual machine uses inverter power to imitate the performance of the conventional synchronous machine.It also has the same inertia,damping,frequency,voltage regulation,and other external performance as the generator.It is the key technology to realize new energy grid connections’stable and reliable operation.This project studies a dynamic simulation model of an extensive new energy power system based on the virtual synchronous motor.A new energy storage method is proposed.The mathematical energy storage model is established by combining the fixed rotor model of a synchronous virtual machine with the charge-discharge power,state of charge,operation efficiency,dead zone,and inverter constraint.The rapid conversion of energy storage devices absorbs the excess instantaneous kinetic energy caused by interference.The branch transient of the critical cut set in the system can be confined to a limited area.Thus,the virtual synchronizer’s kinetic and potential energy can be efficiently converted into an instantaneous state.The simulation of power system analysis software package(PSASP)verifies the correctness of the theory and algorithm in this paper.This paper provides a theoretical basis for improving the transient stability of new energy-connected power grids.展开更多
AIM:To investigate the impact of niosome nanoparticles carrying umbelliprenin(UMB),an anti-angiogenic and anti-inflammatory plant compound,on the expression of vascular endothelial growth factor(VEGF-A)and connective ...AIM:To investigate the impact of niosome nanoparticles carrying umbelliprenin(UMB),an anti-angiogenic and anti-inflammatory plant compound,on the expression of vascular endothelial growth factor(VEGF-A)and connective tissue growth factor(CTGF)genes in a human retinal pigment epithelium(RPE)-like retina-derived cell line.METHODS:UMB-containing niosomes were created,optimized,and characterized.RPE-like cells were treated with free UMB and UMB-containing niosomes.The IC_(50)values of the treatments were determined using an MTT assay.Gene expression of VEGF-A and CTGF was evaluated using real-time polymerase chain reaction after RNA extraction and cDNA synthesis.Niosomes’characteristics,including drug entrapment efficiency,size,dispersion index,and zeta potential were assessed.Free UMB had an IC_(50)of 96.2μg/mL,while UMB-containing niosomes had an IC_(50)of 25μg/mL.RESULTS:Treatment with UMB-containing niosomes and free UMB resulted in a significant reduction in VEGF-A expression compared to control cells(P=0.001).Additionally,UMB-containing niosomes demonstrated a significant reduction in CTGF expression compared to control cells(P=0.05).However,there was no significant reduction in the expression of both genes in cells treated with free UMB.CONCLUSION:Both free UMB and niosome-encapsulated UMB inhibits VEGF-A and CTGF genes expression.However,the latter demonstrates significantly greater efficacy,potentially due to the lower UMB dosage and gradual delivery.These findings have implications for anti-angiogenesis therapeutic approaches targeting age-related macular degeneration.展开更多
Urban tourism is considered a complex system,and multiscale exploration of the organizational patterns of attraction networks has become a topical issue in urban tourism,so exploring the multiscale characteristics and...Urban tourism is considered a complex system,and multiscale exploration of the organizational patterns of attraction networks has become a topical issue in urban tourism,so exploring the multiscale characteristics and connection mechanisms of attraction networks is important for understanding the linkages between attractions and even the future destination planning.This paper uses geotagging data to compare the links between attractions in Beijing,China during four different periods:the pre-Olympic period(2004–2007),the Olympic Games and subsequent‘heat period’(2008–2013),the post-Olympic period(2014–2019),and the COVID-19(Corona Virus Disease 2019)pandemic period(2020–2021).The aim is to better understand the evolution and patterns of attraction networks at different scales in Beijing and to provide insights for tourism planning in the destination.The results show that the macro,meso-,and microscales network characteristics of attraction networks have inherent logical relationships that can explain the commonalities and differences in the development process of tourism networks.The macroscale attraction network degree Matthew effect is significant in the four different periods and exhibits a morphological monocentric structure,suggesting that new entrants are more likely to be associated with attractions that already have high value.The mesoscale links attractions according to the common purpose of tourists,and the results of the community segmentation of the attraction networks in the four different periods suggest that the functional polycentric structure describes their clustering effect,and the weak links between clusters result from attractions bound by incomplete information and distance,and the functional polycentric structure with a generally more efficient network of clusters.The pattern structure at the microscale reveals the topological transformation relationship of the regional collaboration pattern,and the attraction network structure in the four different periods has a very similar importance profile structure suggesting that the attraction network has the same construction rules and evolution mechanism,which aids in understanding the attraction network pattern at both macro and micro scales.Important approaches and practical implications for planners and managers are presented.展开更多
The gut-brain connection is a bidirectional communication system that links the gut microbiome to the central nervous system (CNS). The gut-brain axis communicates through a variety of mechanisms, including the releas...The gut-brain connection is a bidirectional communication system that links the gut microbiome to the central nervous system (CNS). The gut-brain axis communicates through a variety of mechanisms, including the release of hormones, neurotransmitters, and cytokines. These signaling molecules can travel from the gut to the brain and vice versa, influencing various physiological and cognitive functions. Emerging therapeutic strategies targeting the gut-brain connection include probiotics, prebiotics, and faecal microbiota transplantation (FMT). Probiotics are live microorganisms that are similar to the beneficial bacteria that are naturally found in the gut. Prebiotics are non-digestible fibers that feed the beneficial bacteria in the gut. FMT is a procedure in which faecal matter from a healthy donor is transplanted into the gut of a person with a diseased microbiome. Probiotics, prebiotics, and FMT have been shown to be effective in treating a variety of gastrointestinal disorders, and there is growing evidence that they may also be effective in treating neurological and psychiatric disorders. This review explores the emerging field of the gut-brain connection, focusing on the communication pathways between the gut microbiome and the central nervous system. We summarize the potential roles of gut dysbiosis in various neurological and psychiatric disorders. Additionally, we discuss potential therapeutic strategies, research limitations, and future directions in this exciting area of research. More research is needed to fully understand the mechanisms underlying the gut-brain connection and to develop safe and effective therapies that target this pathway. However, the findings to date are promising, and there is the potential to revolutionize the way we diagnose and treat a variety of neurological and psychiatric disorders.展开更多
As companies look to reduce their carbon footprint,the green electricity market is growing by leaps and bounds in China By purchasing Green Electricity Certificates(GECs),the organisers of the seventh China Internatio...As companies look to reduce their carbon footprint,the green electricity market is growing by leaps and bounds in China By purchasing Green Electricity Certificates(GECs),the organisers of the seventh China International Import Expo(CIIE)have succeeded in making the once energy-intensive event more environmentally friendly.展开更多
Digital services stand out at this year’s China International Fair for Trade in Services.Visitors gathered around a large screen displaying scenes from the video game Black Myth:Wukong,China’s first AAA title,where ...Digital services stand out at this year’s China International Fair for Trade in Services.Visitors gathered around a large screen displaying scenes from the video game Black Myth:Wukong,China’s first AAA title,where they learnt that the monkey king can move with lifelike fluidity,performing seamless actions,thanks to Virtual Motion’s state-of-the-art motion capture technology.展开更多
The joint-bolt-African Vulture optimization algorithm(AVOA)model is proposed for the design of building connections to improve the stability of steel beam-to-column connections.For this algorithm,the type of steel is ...The joint-bolt-African Vulture optimization algorithm(AVOA)model is proposed for the design of building connections to improve the stability of steel beam-to-column connections.For this algorithm,the type of steel is first determined,and the number of bolts needed by the corresponding steel type is referenced in Eurocode 3.Then,the bearing capacity of the joint can be calculated.The joint-bolt-AVOA model is established by substituting the bolt number required by the steel into the algorithm to obtain the optimal bolt number required while ensuring joint stability.The results show that the number of bolts required by the joint-bolt-AVOA model based on the stability of steel is lower than that calculated by Eurocode 3.Therefore,AVOA can effectively optimize the number of bolts needed in building connections and save resources.展开更多
Patients with age-related hearing loss face hearing difficulties in daily life.The causes of age-related hearing loss are complex and include changes in peripheral hearing,central processing,and cognitive-related abil...Patients with age-related hearing loss face hearing difficulties in daily life.The causes of age-related hearing loss are complex and include changes in peripheral hearing,central processing,and cognitive-related abilities.Furthermore,the factors by which aging relates to hearing loss via changes in audito ry processing ability are still unclear.In this cross-sectional study,we evaluated 27 older adults(over 60 years old) with age-related hearing loss,21 older adults(over 60years old) with normal hearing,and 30 younger subjects(18-30 years old) with normal hearing.We used the outcome of the uppe r-threshold test,including the time-compressed thres h old and the speech recognition threshold in noisy conditions,as a behavioral indicator of auditory processing ability.We also used electroencephalogra p hy to identify presbycusis-related abnormalities in the brain while the participants were in a spontaneous resting state.The timecompressed threshold and speech recognition threshold data indicated significant diffe rences among the groups.In patients with age-related hearing loss,information masking(babble noise) had a greater effect than energy masking(speech-shaped noise) on processing difficulties.In terms of resting-state electroencephalography signals,we observed enhanced fro ntal lobe(Brodmann’s area,BA11) activation in the older adults with normal hearing compared with the younger participants with normal hearing,and greater activation in the parietal(BA7) and occipital(BA19) lobes in the individuals with age-related hearing loss compared with the younger adults.Our functional connection analysis suggested that compared with younger people,the older adults with normal hearing exhibited enhanced connections among networks,including the default mode network,sensorimotor network,cingulo-opercular network,occipital network,and frontoparietal network.These results suggest that both normal aging and the development of age-related hearing loss have a negative effect on advanced audito ry processing capabilities and that hearing loss accele rates the decline in speech comprehension,especially in speech competition situations.Older adults with normal hearing may have increased compensatory attentional resource recruitment represented by the to p-down active listening mechanism,while those with age-related hearing loss exhibit decompensation of network connections involving multisensory integration.展开更多
A new microreactor with continuous serially connected micromixers(CSCM)was tailored for the coprecipitation process to synthesize Fe_(3)O_(4) nanoparticles.Numerical simulation reveals that the two types of CSCM micro...A new microreactor with continuous serially connected micromixers(CSCM)was tailored for the coprecipitation process to synthesize Fe_(3)O_(4) nanoparticles.Numerical simulation reveals that the two types of CSCM microchannels(V-typed and U-typed)proposed in this work exhibited markedly better mixing performances than the Zigzag and capillary microchannels due to the promotion of Dean vortices.Complete mixing was achieved in the V-typed microchannel in 2.7 s at an inlet Reynolds number of 27.Fe_(3)O_(4) nanoparticles synthesized in a planar glass microreactor with the V-typed microchannel,possessing an average size of 9.3 nm and exhibiting superparamagnetism,had obviously better dispersity and uniformity and higher crystallinity than those obtained in the capillary microreactor.The new CSCM microreactor developed in this work can act as a potent device to intensify the synthesis of similar inorganic nanoparticles via multistep chemical precipitation processes.展开更多
Topological indices(TIs)have been practiced for distinct wide-ranging physicochemical applications,especially used to characterize and model the chemical structures of various molecular compounds such as dendrimers,na...Topological indices(TIs)have been practiced for distinct wide-ranging physicochemical applications,especially used to characterize and model the chemical structures of various molecular compounds such as dendrimers,nanotubes and neural networks with respect to their certain properties such as solubility,chemical stability and low cytotoxicity.Dendrimers are prolonged artificially synthesized or amalgamated natural macromolecules with a sequential layer of branches enclosing a central core.A present-day trend in mathematical and computational chemistry is the characterization of molecular structure by applying topological approaches,including numerical graph invariants.Among topological descriptors,Zagreb connection indices(ZCIs)have much importance.This manuscript involves the establishment of general results to calculate ZCIs,namely first ZCI(FZCI),second ZCI(SZCI),third ZCI(TZCI),modified FZCI,modified SZCI and modified TZCI of two special types of dendrimers nanostars,namely,poly propylene imine octamin(PPIO)dendrimer and poly(propyl)ether imine(PPEtIm)dendrimer.Furthermore,we provide the numerical and graphical comparative analysis of our calculated results for both types of dendrimers with each other.展开更多
Background:Partial anomalous pulmonary venous connection(PAPVC)is frequently associated with atrial septal defect(ASD),especially sinus venosus defect(SVD).Although Waggstaffe described the pathology of SVDs in 1868,t...Background:Partial anomalous pulmonary venous connection(PAPVC)is frequently associated with atrial septal defect(ASD),especially sinus venosus defect(SVD).Although Waggstaffe described the pathology of SVDs in 1868,the exact anatomic features and the nature of SVD remains controversial.SVDs with no posterior atrial rim were observed in recent years.However,no studies suggested that absence of the residual posterior atrial septal tissue might be the key feature of SVD.The aims of this study were to investigate if absence of posterior rim of atrial septum played a crucial role in patients with SVD.Methods:From January 2011 to December 2019,256 children with PAPVC combined ASD and 878 children with isolated ASD who underwent corrective cardiac surgery were consecutively enrolled.Comprehensive review of preoperative transthoracic echocardiography,computed-tomography images and surgical findings were performed by experienced pediatric cardiologists.The subtypes of PAPVC,locations and types of ASD,and presence of posterior atrial rim of associated ASD were investigated.Results:PAPVC was right-sided in 244 children,left-sided in 6 children,and bilateral in 6 children.In PAPVC cases,ASD without posterior atrial rim existed in 226 SVD cases.ASD without posterior atrial septum only existed in cases with one or more right pulmonary veins returning to right atrium(RA)or to RA-superior vena cava junction.In cases with isolated ASD,there were 3 SVD,and the other 875 cases were secundum ASD.Conclusions:ASD without posterior atrial rims was associated with one or more right pulmonary veins returning to RA or RA-superior venous cava(SVC)junction.For SVD,the key feature is that the defect is in the posterior of the interatrial septum with no posterior septal rim,rather than adjacent to the SVC or to the inferior vena cava.展开更多
I show how many connections of Γ?are presently existing from R?to β?as they are being inputted simultaneously through tensor products. I plan to address the Quantum state of this tensor connection st...I show how many connections of Γ?are presently existing from R?to β?as they are being inputted simultaneously through tensor products. I plan to address the Quantum state of this tensor connection step by step throughout the application presented. Also, I will show you how to prove that the connection is true for this tensor connection through its output method using a small bit of tensor calculus and mostly number theory.展开更多
Based on the background of structural protection and Disaster Reduction Engineering, the dynamic behaviour and failure mechanism of restrained beams in portal steel frames in localised fire are investigated via experi...Based on the background of structural protection and Disaster Reduction Engineering, the dynamic behaviour and failure mechanism of restrained beams in portal steel frames in localised fire are investigated via experimental measurement and numerical simulation techniques. Comprehensive parametric studies are carried out to discuss the influence of end connection types, temperature, impact velocity,impact mass and span-to-depth ratio(SDR) on the dynamic response of the beams. The characteristics of deformation, internal force and energy distribution about the restrained beams and its joints are investigated. A temperature dependent criterion for evaluating the frame joint performance is proposed to measure the degree of performance degradation and impact resistance of the joint. The dynamic displacement amplification factor in different temperature environments are proposed for the different beam end constraint types and SDRs. Results of the experimental and numerical analysis show that the welded connection(WC) of three typical joint types is the strongest, and the extended endplate connection(EEC) is the weakest in terms of the impact resistance performance. With regard to the failure mode of the joint, the failure positions of the WC and the welded-bolted connection are located in the inner web of the column. Meanwhile, the EEC is located in the connection position between the beam and the endplate. Three different internal force stages and two obvious critical temperature boundaries of the restrained beams emerge with the increase in temperature, and they have significant characteristics in terms of deformation trend, internal force transfer and energy distribution. During the impact, a phenomenon known as “compression arch action” develops into “catenary action” with the increase in deflection in the frame beam mechanism.展开更多
Efficient flow simulation and optimization methods of hydraulic fracture morphology in unconventional reservoirs are effective ways to enhance oil/gas recovery.Based on the connection element method(CEM)and distributi...Efficient flow simulation and optimization methods of hydraulic fracture morphology in unconventional reservoirs are effective ways to enhance oil/gas recovery.Based on the connection element method(CEM)and distribution of stimulated reservoir volume,the complex hydraulic fracture morphology was accurately described using heterogeneous node connection system.Then a new fracture connection element method(FCEM)for fluid flow in stimulated unconventional reservoirs with complex hydraulic fracture morphology was proposed.In the proposed FCEM,the arrangement of dense nodes in the stimulated area and sparse nodes in the unstimulated area ensures the calculation accuracy and efficiency.The key parameter,transmissibility,was also modified according to the strong heterogeneity of stimulated reservoirs.The finite difference and semi-analytical tracking were used to accurately solve the pressure and saturation distribution between nodes.The FCEM is validated by comparing with traditional numerical simulation method,and the results show that the bottom hole pressure simulated by the FCEM is consistent with the results from traditional numerical simulation method,and the matching rate is larger than 95%.The proposed FCEM was also used in the optimization of fracturing parameters by coupling the hydraulic fracture propagation method and intelligent optimization algorithm.The integrated intelligent optimization approach for multi-parameters,such as perforation number,perforation location,and displacement in hydraulic fracturing is proposed.The proposed approach was applied in a shale gas reservoir,and the result shows that the optimized perforation location and morphology distribution are related to the distribution of porosity/permeability.When the perforation location and displacement are optimized with the same fracture number,NPV increases by 70.58%,which greatly improves the economic benefits of unconventional reservoirs.This work provides a new way for flow simulation and optimization of hydraulic fracture morphology of multi-fractured horizontal wells in unconventional reservoirs.展开更多
Islands and the mainland are separated by seas,and the distances between them might be so long that the height on the mainland cannot be exactly translated to the islands,resulting in different height systems on the m...Islands and the mainland are separated by seas,and the distances between them might be so long that the height on the mainland cannot be exactly translated to the islands,resulting in different height systems on the mainland and the islands.In this study,we used astrogeodetic deflections of the vertical and ellipsoidal heights of points on the mainland and island near their coastlines to implement height connection across sea areas.First,the modeled gravity and modeled astrogeodetic vertical deflections of segmentation points along connecting routes over the sea between the mainland and the island were determined by Earth Gravity Model(EGM),and the ellipsoidal heights of segmentation points were determined by the satellite altimetry data sets.Second,we used a linear interpolation model to increase the precision of the vertical deflections of segmentation points.Third,we computed the geopotential difference of points between the mainland and the island using a method derived from geopotential theory and the astronomical leveling principle.Finally,we estimated the normal height of the point on the island using the geopotential-difference iterative computation approach.Using observed data of normal heights,ellipsoidal heights,and astrogeodetic vertical deflections referring to height sites in Qingdao,Shandong Province,we conducted a numerical experiment involving the normal height connection across sea regions.We determined the data of the ellipsoidal heights and gravity of segmentation points along the connecting route across the water in the numerical experiment using DTU10.The distance of the height connection across the sea was approximately 10.5 km.According to China's official leveling specifications,the experimental results met the criterion of third-class leveling precision.展开更多
Considering the glulam beam-column connection form and the number of bolts,monotonic loading test and finite element analysis was carried out on 9 connection specimens in 3 groups to study the rotational performance a...Considering the glulam beam-column connection form and the number of bolts,monotonic loading test and finite element analysis was carried out on 9 connection specimens in 3 groups to study the rotational performance and failure mode of the connection.The test results revealed that compared with U-shaped connectors,T-shaped connectors can effectively improve the ductility of connections,and the increase in the number of bolts can reduce the initial stiffness and ductility of connections.By theoretical analysis,formulas for calculating the initial stiffness and ultimate moment of connections were deduced.Subsequently,the moment-rotation theoretical model of connections was established based on the formulas,which were validated according to the test data and simulation results.The proposed model can not only improve the current theoretical system of heavy-duty glulam beam-column structure but also provide a theoretical basis for calculating the mechanical properties of the glulam beam-column connection.展开更多
Increasing attention has been focused on the extent to which corporate political connections influence the growing pollution due to the rapid growth in the popularity of firm pollution in developing countries.We adopt...Increasing attention has been focused on the extent to which corporate political connections influence the growing pollution due to the rapid growth in the popularity of firm pollution in developing countries.We adopt a static threshold regression model to investigate the effects of heterogeneous environmental regulation on political connections and firm pollution based on the panel data from China’s A-share listed companies from 2012 to 2019.The empirical results show a non-linear relationship between the degree of political connection of listed company executives and the level of firm pollution.And the relationship between the two roughly presents a U-shaped relationship under the action of the marketincentive environmental regulation threshold.However,it roughly presents an inverted N-shaped relationship under the action of the command-control environmental regulation threshold.Additionally,the group test results show that the existence of regional and ownership heterogeneity causes certain differences in the environmental behaviour of politically connected enterprises.These findings indicate that diverse environmental regulations are needed to promote sustainable green development and to further expand the theoretical and practical exploration of political connections on firm pollution.展开更多
Tetralogy of Fallot(TOF)with total anomalous pulmonary vein connections(TAPVC)is a rare type of complex congenital heart disease among all TOF cases.Co-presentation of major aortopulmonary collateral arteries(MAPCAs)c...Tetralogy of Fallot(TOF)with total anomalous pulmonary vein connections(TAPVC)is a rare type of complex congenital heart disease among all TOF cases.Co-presentation of major aortopulmonary collateral arteries(MAPCAs)compensates for the lack of central pulmonary bloodflow and decreases the severity of right-to-left shunting in TOF.We present a case of a 2-year-old child with complex diagnoses of TOF,TAPVC,a large secun-dum atrial septal defect(ASD),and intraoperatively identified MAPCAs.She underwent surgery to repair the TAPVC,valve-sparing reconstruction of the right ventricular outflow tract,interventricular defect closure,and the creation of patent foramen ovale(PFO).After the operation,hemodynamic instability happened along with sudden blood pressure drop,desaturation,and increased central venous pressure,which subsided after adminis-tering inhalational nitric oxide(NO).A postoperative pulmonary hypertension crisis was suggested when the patient experienced recurrent symptoms after the termination of NO.Echocardiographicfindings of a D-shaped left ventricle(LV),right-to-left PFO shunt and high tricuspid valve gradientfirmly established the diagnosis.It was subsequently managed with continuous NO inhalation and sildenafil,which rendered a satisfactory outcome.Repaired TOF and TAPVC could be at particular risk of developing pulmonary hypertension crisis,especially in the presence of MAPCAs due to possible remodeling of the pulmonary vasculature.Furthermore,a relatively non-compliant LV function and small left atrial size may exacerbate the risk of developing postcapillary pulmonary hypertension after TAPVC repair.A successful postoperative outcome calls for a meticulous preoperative analysis of the anatomical lesions,as well as careful monitoring.展开更多
基金supported by NSFC project(grant No.61971359)Chongqing Municipal Key Laboratory of Institutions of Higher Education(grant No.cquptmct-202104)+1 种基金Fundamental Research Funds for the Central Universities,Sichuan Science and Technology Project(grant no.2021YFQ0053)State Key Laboratory of Rail Transit Engineering Informatization(FSDI).
文摘The increasing demand for industrial automation and intelligence has put forward higher requirements for the reliability of industrial wireless communication technology.As an international standard based on 802.11,Wireless networks for Industrial Automation-Factory Automation(WIA-FA)greatly improves the reliability in factory automation scenarios by Time Division Multiple Access(TDMA).However,in ultra-dense WIA-FA networks with mobile users,the basic connection management mechanism is inefficient.Most of the handover and resource management algorithms are all based on frequency division multiplexing,not suitable for the TDMA in the WIA-FA network.Therefore,we propose Load-aware Connection Management(LACM)algorithm to adjust the linkage and balance the load of access devices to avoid blocking and improve the reliability of the system.And then we simulate the algorithm to find the optimal settings of the parameters.After comparing with other existing algorithms,the result of the simulation proves that LACM is more efficient in reliability and maintains high reliability of more than 99.8%even in the ultra-dense moving scenario with 1500 field devices.Besides,this algorithm ensures that only a few signaling exchanges are required to ensure load bal-ancing,which is no more than 5 times,and less than half of the best state-of-the-art algorithm.
基金National Key R&D Program of China under Grant No.2022YFC3003603。
文摘Seismic fragility analysis of three-tower cable-stayed bridges with three different structural systems,including rigid system(RS),floating system(FS),and passive energy dissipation system(PEDS),is conducted to study the effects of connection configurations on seismic responses and fragilities.Finite element models of bridges are established using OpenSees.A new ground motion screening method based on the statistical characteristic of the predominant period is proposed to avoid irregular behavior in the selection process of ground motions,and incremental dynamic analysis(IDA)is performed to develop components and systems fragility curves.The effects of damper failure on calculated results for PEDS are examined in terms of seismic response and fragility analysis.The results show that the bridge tower is the most affected component by different structural systems.For RS,the fragility of the middle tower is significantly higher than other components,and the bridge failure starts from the middle tower,exhibiting a characteristic of local failure.For FS and PEDS,the fragility of the edge tower is higher than the middle tower.The system fragility of RS is higher than FS and PEDS.Taking the failure of dampers into account is necessary to obtain reliable seismic capacity of cable-stayed bridges.
文摘The synchronous virtual machine uses inverter power to imitate the performance of the conventional synchronous machine.It also has the same inertia,damping,frequency,voltage regulation,and other external performance as the generator.It is the key technology to realize new energy grid connections’stable and reliable operation.This project studies a dynamic simulation model of an extensive new energy power system based on the virtual synchronous motor.A new energy storage method is proposed.The mathematical energy storage model is established by combining the fixed rotor model of a synchronous virtual machine with the charge-discharge power,state of charge,operation efficiency,dead zone,and inverter constraint.The rapid conversion of energy storage devices absorbs the excess instantaneous kinetic energy caused by interference.The branch transient of the critical cut set in the system can be confined to a limited area.Thus,the virtual synchronizer’s kinetic and potential energy can be efficiently converted into an instantaneous state.The simulation of power system analysis software package(PSASP)verifies the correctness of the theory and algorithm in this paper.This paper provides a theoretical basis for improving the transient stability of new energy-connected power grids.
基金Supported by Stem Cell Research Center of Golestan University of Medical Sciences(No.110480).
文摘AIM:To investigate the impact of niosome nanoparticles carrying umbelliprenin(UMB),an anti-angiogenic and anti-inflammatory plant compound,on the expression of vascular endothelial growth factor(VEGF-A)and connective tissue growth factor(CTGF)genes in a human retinal pigment epithelium(RPE)-like retina-derived cell line.METHODS:UMB-containing niosomes were created,optimized,and characterized.RPE-like cells were treated with free UMB and UMB-containing niosomes.The IC_(50)values of the treatments were determined using an MTT assay.Gene expression of VEGF-A and CTGF was evaluated using real-time polymerase chain reaction after RNA extraction and cDNA synthesis.Niosomes’characteristics,including drug entrapment efficiency,size,dispersion index,and zeta potential were assessed.Free UMB had an IC_(50)of 96.2μg/mL,while UMB-containing niosomes had an IC_(50)of 25μg/mL.RESULTS:Treatment with UMB-containing niosomes and free UMB resulted in a significant reduction in VEGF-A expression compared to control cells(P=0.001).Additionally,UMB-containing niosomes demonstrated a significant reduction in CTGF expression compared to control cells(P=0.05).However,there was no significant reduction in the expression of both genes in cells treated with free UMB.CONCLUSION:Both free UMB and niosome-encapsulated UMB inhibits VEGF-A and CTGF genes expression.However,the latter demonstrates significantly greater efficacy,potentially due to the lower UMB dosage and gradual delivery.These findings have implications for anti-angiogenesis therapeutic approaches targeting age-related macular degeneration.
基金Under the auspices of the National Natural Science Foundation of China(No.41971202)the National Natural Science Foundation of China(No.42201181)the Fundamental research funding targets for central universities(No.2412022QD002)。
文摘Urban tourism is considered a complex system,and multiscale exploration of the organizational patterns of attraction networks has become a topical issue in urban tourism,so exploring the multiscale characteristics and connection mechanisms of attraction networks is important for understanding the linkages between attractions and even the future destination planning.This paper uses geotagging data to compare the links between attractions in Beijing,China during four different periods:the pre-Olympic period(2004–2007),the Olympic Games and subsequent‘heat period’(2008–2013),the post-Olympic period(2014–2019),and the COVID-19(Corona Virus Disease 2019)pandemic period(2020–2021).The aim is to better understand the evolution and patterns of attraction networks at different scales in Beijing and to provide insights for tourism planning in the destination.The results show that the macro,meso-,and microscales network characteristics of attraction networks have inherent logical relationships that can explain the commonalities and differences in the development process of tourism networks.The macroscale attraction network degree Matthew effect is significant in the four different periods and exhibits a morphological monocentric structure,suggesting that new entrants are more likely to be associated with attractions that already have high value.The mesoscale links attractions according to the common purpose of tourists,and the results of the community segmentation of the attraction networks in the four different periods suggest that the functional polycentric structure describes their clustering effect,and the weak links between clusters result from attractions bound by incomplete information and distance,and the functional polycentric structure with a generally more efficient network of clusters.The pattern structure at the microscale reveals the topological transformation relationship of the regional collaboration pattern,and the attraction network structure in the four different periods has a very similar importance profile structure suggesting that the attraction network has the same construction rules and evolution mechanism,which aids in understanding the attraction network pattern at both macro and micro scales.Important approaches and practical implications for planners and managers are presented.
文摘The gut-brain connection is a bidirectional communication system that links the gut microbiome to the central nervous system (CNS). The gut-brain axis communicates through a variety of mechanisms, including the release of hormones, neurotransmitters, and cytokines. These signaling molecules can travel from the gut to the brain and vice versa, influencing various physiological and cognitive functions. Emerging therapeutic strategies targeting the gut-brain connection include probiotics, prebiotics, and faecal microbiota transplantation (FMT). Probiotics are live microorganisms that are similar to the beneficial bacteria that are naturally found in the gut. Prebiotics are non-digestible fibers that feed the beneficial bacteria in the gut. FMT is a procedure in which faecal matter from a healthy donor is transplanted into the gut of a person with a diseased microbiome. Probiotics, prebiotics, and FMT have been shown to be effective in treating a variety of gastrointestinal disorders, and there is growing evidence that they may also be effective in treating neurological and psychiatric disorders. This review explores the emerging field of the gut-brain connection, focusing on the communication pathways between the gut microbiome and the central nervous system. We summarize the potential roles of gut dysbiosis in various neurological and psychiatric disorders. Additionally, we discuss potential therapeutic strategies, research limitations, and future directions in this exciting area of research. More research is needed to fully understand the mechanisms underlying the gut-brain connection and to develop safe and effective therapies that target this pathway. However, the findings to date are promising, and there is the potential to revolutionize the way we diagnose and treat a variety of neurological and psychiatric disorders.
文摘As companies look to reduce their carbon footprint,the green electricity market is growing by leaps and bounds in China By purchasing Green Electricity Certificates(GECs),the organisers of the seventh China International Import Expo(CIIE)have succeeded in making the once energy-intensive event more environmentally friendly.
文摘Digital services stand out at this year’s China International Fair for Trade in Services.Visitors gathered around a large screen displaying scenes from the video game Black Myth:Wukong,China’s first AAA title,where they learnt that the monkey king can move with lifelike fluidity,performing seamless actions,thanks to Virtual Motion’s state-of-the-art motion capture technology.
文摘The joint-bolt-African Vulture optimization algorithm(AVOA)model is proposed for the design of building connections to improve the stability of steel beam-to-column connections.For this algorithm,the type of steel is first determined,and the number of bolts needed by the corresponding steel type is referenced in Eurocode 3.Then,the bearing capacity of the joint can be calculated.The joint-bolt-AVOA model is established by substituting the bolt number required by the steel into the algorithm to obtain the optimal bolt number required while ensuring joint stability.The results show that the number of bolts required by the joint-bolt-AVOA model based on the stability of steel is lower than that calculated by Eurocode 3.Therefore,AVOA can effectively optimize the number of bolts needed in building connections and save resources.
基金supported by the National Natural Science Foundation of China,Nos.82171138 (to YQZ),82071 062 (to YXC)the Natural Science Foundation of Guangdong Province,No.2021A1515012038 (to YXC)+1 种基金the Fundamental Research Funds for the Central Universities,No.20ykpy91 (to YXC)the Sun Yat-Sen Clinical Research Cultivating Program,No.SYS-Q-201903 (to YXC)。
文摘Patients with age-related hearing loss face hearing difficulties in daily life.The causes of age-related hearing loss are complex and include changes in peripheral hearing,central processing,and cognitive-related abilities.Furthermore,the factors by which aging relates to hearing loss via changes in audito ry processing ability are still unclear.In this cross-sectional study,we evaluated 27 older adults(over 60 years old) with age-related hearing loss,21 older adults(over 60years old) with normal hearing,and 30 younger subjects(18-30 years old) with normal hearing.We used the outcome of the uppe r-threshold test,including the time-compressed thres h old and the speech recognition threshold in noisy conditions,as a behavioral indicator of auditory processing ability.We also used electroencephalogra p hy to identify presbycusis-related abnormalities in the brain while the participants were in a spontaneous resting state.The timecompressed threshold and speech recognition threshold data indicated significant diffe rences among the groups.In patients with age-related hearing loss,information masking(babble noise) had a greater effect than energy masking(speech-shaped noise) on processing difficulties.In terms of resting-state electroencephalography signals,we observed enhanced fro ntal lobe(Brodmann’s area,BA11) activation in the older adults with normal hearing compared with the younger participants with normal hearing,and greater activation in the parietal(BA7) and occipital(BA19) lobes in the individuals with age-related hearing loss compared with the younger adults.Our functional connection analysis suggested that compared with younger people,the older adults with normal hearing exhibited enhanced connections among networks,including the default mode network,sensorimotor network,cingulo-opercular network,occipital network,and frontoparietal network.These results suggest that both normal aging and the development of age-related hearing loss have a negative effect on advanced audito ry processing capabilities and that hearing loss accele rates the decline in speech comprehension,especially in speech competition situations.Older adults with normal hearing may have increased compensatory attentional resource recruitment represented by the to p-down active listening mechanism,while those with age-related hearing loss exhibit decompensation of network connections involving multisensory integration.
基金the financial support from the National Natural Science Foundation of China(21808059)the Fundamental Research Funds for the Central Universities(JKA01221712).
文摘A new microreactor with continuous serially connected micromixers(CSCM)was tailored for the coprecipitation process to synthesize Fe_(3)O_(4) nanoparticles.Numerical simulation reveals that the two types of CSCM microchannels(V-typed and U-typed)proposed in this work exhibited markedly better mixing performances than the Zigzag and capillary microchannels due to the promotion of Dean vortices.Complete mixing was achieved in the V-typed microchannel in 2.7 s at an inlet Reynolds number of 27.Fe_(3)O_(4) nanoparticles synthesized in a planar glass microreactor with the V-typed microchannel,possessing an average size of 9.3 nm and exhibiting superparamagnetism,had obviously better dispersity and uniformity and higher crystallinity than those obtained in the capillary microreactor.The new CSCM microreactor developed in this work can act as a potent device to intensify the synthesis of similar inorganic nanoparticles via multistep chemical precipitation processes.
文摘Topological indices(TIs)have been practiced for distinct wide-ranging physicochemical applications,especially used to characterize and model the chemical structures of various molecular compounds such as dendrimers,nanotubes and neural networks with respect to their certain properties such as solubility,chemical stability and low cytotoxicity.Dendrimers are prolonged artificially synthesized or amalgamated natural macromolecules with a sequential layer of branches enclosing a central core.A present-day trend in mathematical and computational chemistry is the characterization of molecular structure by applying topological approaches,including numerical graph invariants.Among topological descriptors,Zagreb connection indices(ZCIs)have much importance.This manuscript involves the establishment of general results to calculate ZCIs,namely first ZCI(FZCI),second ZCI(SZCI),third ZCI(TZCI),modified FZCI,modified SZCI and modified TZCI of two special types of dendrimers nanostars,namely,poly propylene imine octamin(PPIO)dendrimer and poly(propyl)ether imine(PPEtIm)dendrimer.Furthermore,we provide the numerical and graphical comparative analysis of our calculated results for both types of dendrimers with each other.
基金The current study was supported by the National Key R&D Program of China[2018YFC1002600]Science and Technology Planning Project of Guangdong Province[Nos.2018B090944002,2019B020230003 and 2018KJY2017]+1 种基金Guangdong Peak Project of Guangdong Province[DFJH201802]the Shenzhen San-Ming Project.
文摘Background:Partial anomalous pulmonary venous connection(PAPVC)is frequently associated with atrial septal defect(ASD),especially sinus venosus defect(SVD).Although Waggstaffe described the pathology of SVDs in 1868,the exact anatomic features and the nature of SVD remains controversial.SVDs with no posterior atrial rim were observed in recent years.However,no studies suggested that absence of the residual posterior atrial septal tissue might be the key feature of SVD.The aims of this study were to investigate if absence of posterior rim of atrial septum played a crucial role in patients with SVD.Methods:From January 2011 to December 2019,256 children with PAPVC combined ASD and 878 children with isolated ASD who underwent corrective cardiac surgery were consecutively enrolled.Comprehensive review of preoperative transthoracic echocardiography,computed-tomography images and surgical findings were performed by experienced pediatric cardiologists.The subtypes of PAPVC,locations and types of ASD,and presence of posterior atrial rim of associated ASD were investigated.Results:PAPVC was right-sided in 244 children,left-sided in 6 children,and bilateral in 6 children.In PAPVC cases,ASD without posterior atrial rim existed in 226 SVD cases.ASD without posterior atrial septum only existed in cases with one or more right pulmonary veins returning to right atrium(RA)or to RA-superior vena cava junction.In cases with isolated ASD,there were 3 SVD,and the other 875 cases were secundum ASD.Conclusions:ASD without posterior atrial rims was associated with one or more right pulmonary veins returning to RA or RA-superior venous cava(SVC)junction.For SVD,the key feature is that the defect is in the posterior of the interatrial septum with no posterior septal rim,rather than adjacent to the SVC or to the inferior vena cava.
文摘I show how many connections of Γ?are presently existing from R?to β?as they are being inputted simultaneously through tensor products. I plan to address the Quantum state of this tensor connection step by step throughout the application presented. Also, I will show you how to prove that the connection is true for this tensor connection through its output method using a small bit of tensor calculus and mostly number theory.
基金supported by the National natural Science Foundation of China [grant numbers 12172198, 11272189 and 52078283]Youth Innovation Technology Project of Higher School in Shandong Province [grant number 2019KJG015]。
文摘Based on the background of structural protection and Disaster Reduction Engineering, the dynamic behaviour and failure mechanism of restrained beams in portal steel frames in localised fire are investigated via experimental measurement and numerical simulation techniques. Comprehensive parametric studies are carried out to discuss the influence of end connection types, temperature, impact velocity,impact mass and span-to-depth ratio(SDR) on the dynamic response of the beams. The characteristics of deformation, internal force and energy distribution about the restrained beams and its joints are investigated. A temperature dependent criterion for evaluating the frame joint performance is proposed to measure the degree of performance degradation and impact resistance of the joint. The dynamic displacement amplification factor in different temperature environments are proposed for the different beam end constraint types and SDRs. Results of the experimental and numerical analysis show that the welded connection(WC) of three typical joint types is the strongest, and the extended endplate connection(EEC) is the weakest in terms of the impact resistance performance. With regard to the failure mode of the joint, the failure positions of the WC and the welded-bolted connection are located in the inner web of the column. Meanwhile, the EEC is located in the connection position between the beam and the endplate. Three different internal force stages and two obvious critical temperature boundaries of the restrained beams emerge with the increase in temperature, and they have significant characteristics in terms of deformation trend, internal force transfer and energy distribution. During the impact, a phenomenon known as “compression arch action” develops into “catenary action” with the increase in deflection in the frame beam mechanism.
基金supported the National Natural Science Foundation of China(No.52004033,51922007,and 51874044).
文摘Efficient flow simulation and optimization methods of hydraulic fracture morphology in unconventional reservoirs are effective ways to enhance oil/gas recovery.Based on the connection element method(CEM)and distribution of stimulated reservoir volume,the complex hydraulic fracture morphology was accurately described using heterogeneous node connection system.Then a new fracture connection element method(FCEM)for fluid flow in stimulated unconventional reservoirs with complex hydraulic fracture morphology was proposed.In the proposed FCEM,the arrangement of dense nodes in the stimulated area and sparse nodes in the unstimulated area ensures the calculation accuracy and efficiency.The key parameter,transmissibility,was also modified according to the strong heterogeneity of stimulated reservoirs.The finite difference and semi-analytical tracking were used to accurately solve the pressure and saturation distribution between nodes.The FCEM is validated by comparing with traditional numerical simulation method,and the results show that the bottom hole pressure simulated by the FCEM is consistent with the results from traditional numerical simulation method,and the matching rate is larger than 95%.The proposed FCEM was also used in the optimization of fracturing parameters by coupling the hydraulic fracture propagation method and intelligent optimization algorithm.The integrated intelligent optimization approach for multi-parameters,such as perforation number,perforation location,and displacement in hydraulic fracturing is proposed.The proposed approach was applied in a shale gas reservoir,and the result shows that the optimized perforation location and morphology distribution are related to the distribution of porosity/permeability.When the perforation location and displacement are optimized with the same fracture number,NPV increases by 70.58%,which greatly improves the economic benefits of unconventional reservoirs.This work provides a new way for flow simulation and optimization of hydraulic fracture morphology of multi-fractured horizontal wells in unconventional reservoirs.
基金financially supported by the foundation of the Key Laboratory of Marine Environmental Survey Technology and Application,Ministry of Natural Resources,China (No. MESTA-2020-B006)the National Natural Science Foundation of China (No.41774001)
文摘Islands and the mainland are separated by seas,and the distances between them might be so long that the height on the mainland cannot be exactly translated to the islands,resulting in different height systems on the mainland and the islands.In this study,we used astrogeodetic deflections of the vertical and ellipsoidal heights of points on the mainland and island near their coastlines to implement height connection across sea areas.First,the modeled gravity and modeled astrogeodetic vertical deflections of segmentation points along connecting routes over the sea between the mainland and the island were determined by Earth Gravity Model(EGM),and the ellipsoidal heights of segmentation points were determined by the satellite altimetry data sets.Second,we used a linear interpolation model to increase the precision of the vertical deflections of segmentation points.Third,we computed the geopotential difference of points between the mainland and the island using a method derived from geopotential theory and the astronomical leveling principle.Finally,we estimated the normal height of the point on the island using the geopotential-difference iterative computation approach.Using observed data of normal heights,ellipsoidal heights,and astrogeodetic vertical deflections referring to height sites in Qingdao,Shandong Province,we conducted a numerical experiment involving the normal height connection across sea regions.We determined the data of the ellipsoidal heights and gravity of segmentation points along the connecting route across the water in the numerical experiment using DTU10.The distance of the height connection across the sea was approximately 10.5 km.According to China's official leveling specifications,the experimental results met the criterion of third-class leveling precision.
基金funded by the National First-class Disciplines(PNFD)High Level Natural Science Foundation of Hainan Province of China(Grant No.2019RC055)Project Supported by the Education Department of Hainan Province(Project No.hnjg2021-13).
文摘Considering the glulam beam-column connection form and the number of bolts,monotonic loading test and finite element analysis was carried out on 9 connection specimens in 3 groups to study the rotational performance and failure mode of the connection.The test results revealed that compared with U-shaped connectors,T-shaped connectors can effectively improve the ductility of connections,and the increase in the number of bolts can reduce the initial stiffness and ductility of connections.By theoretical analysis,formulas for calculating the initial stiffness and ultimate moment of connections were deduced.Subsequently,the moment-rotation theoretical model of connections was established based on the formulas,which were validated according to the test data and simulation results.The proposed model can not only improve the current theoretical system of heavy-duty glulam beam-column structure but also provide a theoretical basis for calculating the mechanical properties of the glulam beam-column connection.
基金This work was supported by National Natural Science Foundation of China[No.72091515]the Natural Science Fund of Hunan Province(2022JJ40647).
文摘Increasing attention has been focused on the extent to which corporate political connections influence the growing pollution due to the rapid growth in the popularity of firm pollution in developing countries.We adopt a static threshold regression model to investigate the effects of heterogeneous environmental regulation on political connections and firm pollution based on the panel data from China’s A-share listed companies from 2012 to 2019.The empirical results show a non-linear relationship between the degree of political connection of listed company executives and the level of firm pollution.And the relationship between the two roughly presents a U-shaped relationship under the action of the marketincentive environmental regulation threshold.However,it roughly presents an inverted N-shaped relationship under the action of the command-control environmental regulation threshold.Additionally,the group test results show that the existence of regional and ownership heterogeneity causes certain differences in the environmental behaviour of politically connected enterprises.These findings indicate that diverse environmental regulations are needed to promote sustainable green development and to further expand the theoretical and practical exploration of political connections on firm pollution.
基金The report was conducted in accordance with the Nuremberg Code and Declaration of Helsinki,and the protocol was approved by the Institutional Review Board of National Cardiovascular Center Harapan Kita(No.LB.02.01/VII/037/KEP037/2022).
文摘Tetralogy of Fallot(TOF)with total anomalous pulmonary vein connections(TAPVC)is a rare type of complex congenital heart disease among all TOF cases.Co-presentation of major aortopulmonary collateral arteries(MAPCAs)compensates for the lack of central pulmonary bloodflow and decreases the severity of right-to-left shunting in TOF.We present a case of a 2-year-old child with complex diagnoses of TOF,TAPVC,a large secun-dum atrial septal defect(ASD),and intraoperatively identified MAPCAs.She underwent surgery to repair the TAPVC,valve-sparing reconstruction of the right ventricular outflow tract,interventricular defect closure,and the creation of patent foramen ovale(PFO).After the operation,hemodynamic instability happened along with sudden blood pressure drop,desaturation,and increased central venous pressure,which subsided after adminis-tering inhalational nitric oxide(NO).A postoperative pulmonary hypertension crisis was suggested when the patient experienced recurrent symptoms after the termination of NO.Echocardiographicfindings of a D-shaped left ventricle(LV),right-to-left PFO shunt and high tricuspid valve gradientfirmly established the diagnosis.It was subsequently managed with continuous NO inhalation and sildenafil,which rendered a satisfactory outcome.Repaired TOF and TAPVC could be at particular risk of developing pulmonary hypertension crisis,especially in the presence of MAPCAs due to possible remodeling of the pulmonary vasculature.Furthermore,a relatively non-compliant LV function and small left atrial size may exacerbate the risk of developing postcapillary pulmonary hypertension after TAPVC repair.A successful postoperative outcome calls for a meticulous preoperative analysis of the anatomical lesions,as well as careful monitoring.
