With the development and widespread use of blockchain in recent years,many projects have introduced blockchain technology to solve the growing security issues of the Industrial Internet of Things(IIoT).However,due to ...With the development and widespread use of blockchain in recent years,many projects have introduced blockchain technology to solve the growing security issues of the Industrial Internet of Things(IIoT).However,due to the conflict between the operational performance and security of the blockchain system and the compatibility issues with a large number of IIoT devices running together,the mainstream blockchain system cannot be applied to IIoT scenarios.In order to solve these problems,this paper proposes SBFT(Speculative Byzantine Consensus Protocol),a flexible and scalable blockchain consensus mechanism for the Industrial Internet of Things.SBFT has a consensus process based on speculation,improving the throughput and consensus speed of blockchain systems and reducing communication overhead.In order to improve the compatibility and scalability of the blockchain system,we select some nodes to participate in the consensus,and these nodes have better performance in the network.Since multiple properties determine node performance,we abstract the node selection problem as a joint optimization problem and use Dueling Deep Q Learning(DQL)to solve it.Finally,we evaluate the performance of the scheme through simulation,and the simulation results prove the superiority of our scheme.展开更多
The wide application of intelligent terminals in microgrids has fueled the surge of data amount in recent years.In real-world scenarios,microgrids must store large amounts of data efficiently while also being able to ...The wide application of intelligent terminals in microgrids has fueled the surge of data amount in recent years.In real-world scenarios,microgrids must store large amounts of data efficiently while also being able to withstand malicious cyberattacks.To meet the high hardware resource requirements,address the vulnerability to network attacks and poor reliability in the tradi-tional centralized data storage schemes,this paper proposes a secure storage management method for microgrid data that considers node trust and directed acyclic graph(DAG)consensus mechanism.Firstly,the microgrid data storage model is designed based on the edge computing technology.The blockchain,deployed on the edge computing server and combined with cloud storage,ensures reliable data storage in the microgrid.Secondly,a blockchain consen-sus algorithm based on directed acyclic graph data structure is then proposed to effectively improve the data storage timeliness and avoid disadvantages in traditional blockchain topology such as long chain construction time and low consensus efficiency.Finally,considering the tolerance differences among the candidate chain-building nodes to network attacks,a hash value update mechanism of blockchain header with node trust identification to ensure data storage security is proposed.Experimental results from the microgrid data storage platform show that the proposed method can achieve a private key update time of less than 5 milliseconds.When the number of blockchain nodes is less than 25,the blockchain construction takes no more than 80 mins,and the data throughput is close to 300 kbps.Compared with the traditional chain-topology-based consensus methods that do not consider node trust,the proposed method has higher efficiency in data storage and better resistance to network attacks.展开更多
In LEO(Low Earth Orbit)satellite communication systems,the satellite network is made up of a large number of satellites,the dynamically changing network environment affects the results of distributed computing.In orde...In LEO(Low Earth Orbit)satellite communication systems,the satellite network is made up of a large number of satellites,the dynamically changing network environment affects the results of distributed computing.In order to improve the fault tolerance rate,a novel public blockchain consensus mechanism that applies a distributed computing architecture in a public network is proposed.Redundant calculation of blockchain ensures the credibility of the results;and the transactions with calculation results of a task are stored distributed in sequence in Directed Acyclic Graphs(DAG).The transactions issued by nodes are connected to form a net.The net can quickly provide node reputation evaluation that does not rely on third parties.Simulations show that our proposed blockchain has the following advantages:1.The task processing speed of the blockchain can be close to that of the fastest node in the entire blockchain;2.When the tasks’arrival time intervals and demanded working nodes(WNs)meet certain conditions,the network can tolerate more than 50%of malicious devices;3.No matter the number of nodes in the blockchain is increased or reduced,the network can keep robustness by adjusting the task’s arrival time interval and demanded WNs.展开更多
In recent years,Blockchain is gaining prominence as a hot topic in academic research.However,the consensus mechanism of blockchain has been criticized in terms of energy consumption and performance.Although Proof-of-A...In recent years,Blockchain is gaining prominence as a hot topic in academic research.However,the consensus mechanism of blockchain has been criticized in terms of energy consumption and performance.Although Proof-of-Authority(PoA)consensus mechanism,as a lightweight consensus mechanism,is more efficient than traditional Proof-of-Work(PoW)and Proof-of-Stake(PoS),it suffers from the problem of centralization.To this end,on account of analyzing the shortcomings of existing consensus mechanisms,this paper proposes a dynamic reputation-based consensus mechanism for blockchain.This scheme allows nodes with reputation value higher than a threshold apply to become a monitoring node,which can monitor the behavior of validators in case that validators with excessive power cause harm to the blockchain network.At the same time,the reputation evaluation algorithm is also introduced to select nodes with high reputation to become validators in the network,thus increasing the cost of malicious behavior.In each consensus cycle,validators and monitoring nodes are dynamically updated according to the reputation value.Through security analysis,it is demonstrated that the scheme can resist the attacks of malicious nodes in the blockchain network.By simulation experiments and analysis of the scheme,the result verifies that the mechanism can effectively improve the fault tolerance of the consensus mechanism,reduce the time of consensus to guarantee the security of the system.展开更多
The research on the governing blockchain by blockchain supervision system is an important development trend of blockchain technology.In this system there is a supervisory blockchain managing and governing the supervis...The research on the governing blockchain by blockchain supervision system is an important development trend of blockchain technology.In this system there is a supervisory blockchain managing and governing the supervised blockchain based on blockchain technology,results in a uniquely cross-blockchain demand to consensus mechanism for solving the trust problem between supervisory blockchain and supervised blockchain.To solve this problem,this paper proposes a cross-blockchain consensus mechanism based on smart contract and a set of smart contracts endorse the crossblockchain consensus.New consensus mechanism called Proof-of-EndorseContracts(PoEC)consensus,which firstly transfers the consensus reached in supervisory blockchain to supervised blockchain by supervisory nodes,then packages the supervisory block in supervisory blockchain and transmits it to the smart contract deployed in the supervised blockchain,finally miners in supervised blockchain will execute and package the new block according to the status of the smart contract.The core part of the consensus mechanism is Endorse Contracts which designed and implemented by us and verified the effectiveness through experiments.PoEC consensus mechanism and Endorse Contracts support the supervised blockchain to join the governing blockchain by blockchain system without changing the original consensus mechanism,which has the advantages of low cost,high scalability and being able to crossblockchain.This paper proves that our method can provide a feasible crossblockchain governance scheme for the field of blockchain governance.展开更多
Bitcoin is widely used as the most classic electronic currency for various electronic services such as exchanges,gambling,marketplaces,and also scams such as high-yield investment projects.Identifying the services ope...Bitcoin is widely used as the most classic electronic currency for various electronic services such as exchanges,gambling,marketplaces,and also scams such as high-yield investment projects.Identifying the services operated by a Bitcoin address can help determine the risk level of that address and build an alert model accordingly.Feature engineering can also be used to flesh out labeled addresses and to analyze the current state of Bitcoin in a small way.In this paper,we address the problem of identifying multiple classes of Bitcoin services,and for the poor classification of individual addresses that do not have significant features,we propose a Bitcoin address identification scheme based on joint multi-model prediction using the mapping relationship between addresses and entities.The innovation of the method is to(1)Extract as many valuable features as possible when an address is given to facilitate the multi-class service identification task.(2)Unlike the general supervised model approach,this paper proposes a joint prediction scheme for multiple learners based on address-entity mapping relationships.Specifically,after obtaining the overall features,the address classification and entity clustering tasks are performed separately,and the results are subjected to graph-basedmaximization consensus.The final result ismade to baseline the individual address classification results while satisfying the constraint of having similarly behaving entities as far as possible.By testing and evaluating over 26,000 Bitcoin addresses,our feature extraction method captures more useful features.In addition,the combined multi-learner model obtained results that exceeded the baseline classifier reaching an accuracy of 77.4%.展开更多
Purpose-As the core technology of blockchain,various consensus mechanisms have emerged to satisfy the demands of different application scenarios.Since determining the security,scalability and other related performance...Purpose-As the core technology of blockchain,various consensus mechanisms have emerged to satisfy the demands of different application scenarios.Since determining the security,scalability and other related performance of the blockchain,how to reach consensus efficiently of consensus mechanism is a critical issue in the blockchain.Design/methodology/approach-The paper opted for a research overview on the blockchain consensus mechanism,including the consensus mechanisms’consensus progress,classification and comparison,which are complemented by documentary analysis.Findings-This survey analyzes solutions for the improvement of consensus mechanisms in blockchain that have been proposed during the last few years and suggests future research directions around consensus mechanisms.First,the authors outline the consensus processes,the advantages and disadvantages of the mainstream consensus mechanisms.Additionally,the consensus mechanisms are subdivided into four types according to their characteristics.Then,the consensus mechanisms are compared and analyzed based on four evaluation criteria.Finally,the authors summarize the representative progress of consensus mechanisms and provide some suggestions on the design of consensus mechanisms to make further advances in this field.Originality/value-This paper summarizes the future research development of the consensus mechanisms.展开更多
Effectively identifying and preventing the threat of Byzantine nodes to the security of distributed systems is a challenge in applying consortium chains.Therefore,this paper proposes a new consortium chain generation ...Effectively identifying and preventing the threat of Byzantine nodes to the security of distributed systems is a challenge in applying consortium chains.Therefore,this paper proposes a new consortium chain generation model,deeply analyzes the vulnerability of the consortium chain consensus based on the behavior of the nodes,and points out the effects of Byzantine node proportion and node state verification on the consensus process and system security.Furthermore,the normalized verification node aggregation index that represents the consensus ability of the consortium organization and the trust evaluation function of the verification node set is derived.When either of the two is lower than the threshold,the consortium institution or the verification node set members are dynamically adjusted.On this basis,an innovative consortium chain generation mechanism based on the Asynchronous Binary Byzantine Consensus Mechanism(ABBCM)is proposed.Based on the extended consortium chain consensus mechanism,a certain consensus value set can be combined into multiple proposals,which can realize crossdomain asynchronous message passing between multi-consortium chains without reducing the system’s security.In addition,experiments are carried out under four classical Byzantine Attack(BA)behaviors,BA1 to BA4.The results show that the proposed method can obtain better delay than the classical random Byzantine consensus algorithm Coin,effectively improving the consensus efficiency based on asynchronous message passing in the consortium chain and thus meeting the throughput of most Internet of Things(IoT)applications.展开更多
This research presents a reputation-based blockchain consensus mechanism called Proof of Intelligent Reputation(PoIR)as an alternative to traditional Proof of Work(PoW).PoIR addresses the limitations of existing reput...This research presents a reputation-based blockchain consensus mechanism called Proof of Intelligent Reputation(PoIR)as an alternative to traditional Proof of Work(PoW).PoIR addresses the limitations of existing reputationbased consensus mechanisms by proposing a more decentralized and fair node selection process.The proposed PoIR consensus combines Bidirectional Long Short-Term Memory(BiLSTM)with the Network Entity Reputation Database(NERD)to generate reputation scores for network entities and select authoritative nodes.NERD records network entity profiles based on various sources,i.e.,Warden,Blacklists,DShield,AlienVault Open Threat Exchange(OTX),and MISP(Malware Information Sharing Platform).It summarizes these profile records into a reputation score value.The PoIR consensus mechanism utilizes these reputation scores to select authoritative nodes.The evaluation demonstrates that PoIR exhibits higher centralization resistance than PoS and PoW.Authoritative nodes were selected fairly during the 1000-block proposal round,ensuring a more decentralized blockchain ecosystem.In contrast,malicious nodes successfully monopolized 58%and 32%of transaction processes in PoS and PoW,respectively,but failed to do so in PoIR.The findings also indicate that PoIR offers efficient transaction times of 12 s,outperforms reputation-based consensus such as PoW,and is comparable to reputation-based consensus such as PoS.Furthermore,the model evaluation shows that BiLSTM outperforms other Recurrent Neural Network models,i.e.,BiGRU(Bidirectional Gated Recurrent Unit),UniLSTM(Unidirectional Long Short-Term Memory),and UniGRU(Unidirectional Gated Recurrent Unit)with 0.022 Root Mean Squared Error(RMSE).This study concludes that the PoIR consensus mechanism is more resistant to centralization than PoS and PoW.Integrating BiLSTM and NERD enhances the fairness and efficiency of blockchain applications.展开更多
As the smart grid develops rapidly,abundant connected devices offer various trading data.This raises higher requirements for secure and effective data storage.Traditional centralized data management does not meet the ...As the smart grid develops rapidly,abundant connected devices offer various trading data.This raises higher requirements for secure and effective data storage.Traditional centralized data management does not meet the above requirements.Currently,smart grid with conventional consortium blockchain can solve the above issues.However,in the face of a large number of nodes,existing consensus algorithms often perform poorly in terms of efficiency and throughput.In this paper,we propose a trust-based hierarchical consensus mechanism(THCM)to solve this problem.Firstly,we design a hierarchical mechanism to improve the efficiency and throughput.Then,intra-layer nodes use an improved Raft consensus algorithm and inter-layer nodes use the Byzantine Fault Tolerance algorithm.Thirdly,we propose a trust evaluation method to improve the election process of Raft.Finally,we implement a prototype system to evaluate the performance of THCM.The results demonstrate that the consensus efficiency is improved by 19.8%,the throughput is improved by 12.34%,and the storage is reduced by 37.9%.展开更多
This paper investigates the consensus control of multi-agent systems(MASs) with constrained input using the dynamic event-triggered mechanism(ETM).Consider the MASs with small-scale networks where a centralized dynami...This paper investigates the consensus control of multi-agent systems(MASs) with constrained input using the dynamic event-triggered mechanism(ETM).Consider the MASs with small-scale networks where a centralized dynamic ETM with global information of the MASs is first designed.Then,a distributed dynamic ETM which only uses local information is developed for the MASs with large-scale networks.It is shown that the semi-global consensus of the MASs can be achieved by the designed bounded control protocol where the Zeno phenomenon is eliminated by a designable minimum inter-event time.In addition,it is easier to find a trade-off between the convergence rate and the minimum inter-event time by an adjustable parameter.Furthermore,the results are extended to regional consensus of the MASs with the bounded control protocol.Numerical simulations show the effectiveness of the proposed approach.展开更多
Escherichia coli O157:H7 is one of the major foodborne pathogenic bacterial that cause infectious diseases in humans.The previous found that a combination of kojic acid and tea polyphenols exhibited better activity ag...Escherichia coli O157:H7 is one of the major foodborne pathogenic bacterial that cause infectious diseases in humans.The previous found that a combination of kojic acid and tea polyphenols exhibited better activity against E.coli O157:H7 than using either alone.This study aimed to explore responses underlying the antibacterial mechanisms of kojic acid and tea polyphenols from the gene level.The functional enrichment analysis by comparing kojic acid and tea polyphenols individually or synergistically against E.coli O157:H7 found that acid resistance systems in kojic acid were activated,and the cell membrane and genomic DNA were destructed in the cells,resulting in“oxygen starvation”.The oxidative stress response triggered by tea polyphenols inhibited both sulfur uptake and the synthesis of ATP,which affected the bacteria's life metabolic process.Interestingly,we found that kojic acid combined with tea polyphenols hindered the uptake of iron that played an essential role in the synthesis of DNA,respiration,tricarboxylic acid cycle.The results suggested that the iron uptake pathways may represent a novel approach for kojic acid and tea polyphenols synergistically against E.coli O157:H7 and provided a theoretical basis for bacterial pathogen control in the food industry.展开更多
This paper is concerned with consensus of a secondorder linear time-invariant multi-agent system in the situation that there exists a communication delay among the agents in the network.A proportional-integral consens...This paper is concerned with consensus of a secondorder linear time-invariant multi-agent system in the situation that there exists a communication delay among the agents in the network.A proportional-integral consensus protocol is designed by using delayed and memorized state information.Under the proportional-integral consensus protocol,the consensus problem of the multi-agent system is transformed into the problem of asymptotic stability of the corresponding linear time-invariant time-delay system.Note that the location of the eigenvalues of the corresponding characteristic function of the linear time-invariant time-delay system not only determines the stability of the system,but also plays a critical role in the dynamic performance of the system.In this paper,based on recent results on the distribution of roots of quasi-polynomials,several necessary conditions for Hurwitz stability for a class of quasi-polynomials are first derived.Then allowable regions of consensus protocol parameters are estimated.Some necessary and sufficient conditions for determining effective protocol parameters are provided.The designed protocol can achieve consensus and improve the dynamic performance of the second-order multi-agent system.Moreover,the effects of delays on consensus of systems of harmonic oscillators/double integrators under proportional-integral consensus protocols are investigated.Furthermore,some results on proportional-integral consensus are derived for a class of high-order linear time-invariant multi-agent systems.展开更多
The deformation in sedimentary rock induced by train loads has potential threat to the safe operation of tunnels. This study investigated the influence of stratification structure on the infrared radiation and tempora...The deformation in sedimentary rock induced by train loads has potential threat to the safe operation of tunnels. This study investigated the influence of stratification structure on the infrared radiation and temporal damage mechanism of hard siltstone. The uniaxial compression tests, coupled with acoustic emission(AE) and infrared radiation temperature(IRT) were conducted on siltstones with different stratification effects. The results revealed that the stratigraphic structure significantly affects the stress-strain response and strength degradation characteristics. The mechanical parameters exhibit anisotropy characteristics, and the stratification effect exhibits a negative correlation with the cracking stress and peak stress. The failure modes caused by the stratification effect show remarkable anisotropic features, including splitting failure(Ⅰ: 0°-22.50°, Ⅱ: 90°), composite failure(45°), and shearing failure(67.50°). The AE temporal sequences demonstrate a stepwise response characteristic to the loading stress level. The AE intensity indicates that the stress sensitivity of shearing failure and composite failure is generally greater than that of splitting failure. The IRT field has spatiotemporal migration and progressive dissimilation with stress loading and its dissimilation degree increases under higher stress levels. The stronger the stratification effect, the greater the dissimilation degree of the IRT field. The abnormal characteristic points of average infrared radiation temperature(AIRT) variance at local stress drop and peak stress can be used as early and late precursors to identify fracture instability. Theoretical analysis shows that the competitive relationship between compaction strengthening and fracturing damage intensifies the dissimilation of the infrared thermal field for an increasing stress level. The present study provides a theoretical reference for disaster warnings in hard sedimentary rock mass.展开更多
Understanding the mechanical properties and multiscale failure mechanism of frozen soft rock is an important prerequisite for the construction safety of tunnels,artificially frozen ground and other infrastructure in c...Understanding the mechanical properties and multiscale failure mechanism of frozen soft rock is an important prerequisite for the construction safety of tunnels,artificially frozen ground and other infrastructure in cold regions.In this study,the triaxial compression test are performed on mudstone in the weakly cemented soft rock strata in the mining area of western China,and the mechanical characteristics and failure mechanism of weakly cemented mudstone are systematically investigated under the combined action of freezing and loading.Furthermore,the quantitative relationship between the microstructural parameters and the macroscopic strength and deformation parameters is established based on fractal theory.Thus,the failure mechanism of frozen weakly cemented mudstone is revealed on both micro- and macro-scales.The results show that temperature and confining pressure significantly affects the elastic modulus and peak strength of weakly cemented mudstone.With decreasing temperature,the compressive strength increases,while the corresponding peak strain decreases gradually.On the deformation curve,the plastic deformation stage is shortened,and the brittle fracture feature at the post-peak stage is more prominent,and the elastic modulus correspondingly increases with decreasing temperature.Under low-temperature conditions,most of the weakly cemented mudstone undergoes microscopic shear failure along the main fracture surface.The micro-fracture morphology characteristics of weakly cemented mudstone under different temperatures are quantified via the fractal dimension,and an approximately exponential relationship can be obtained among the fractal dimension and the temperature,compressive strength and elastic modulus.展开更多
The study of the brain and its complex functions is highly fascinating and,at the same time,extremely important.Indeed,furthering our understanding of the biology of neurons and synapses is a prerequisite to uncover t...The study of the brain and its complex functions is highly fascinating and,at the same time,extremely important.Indeed,furthering our understanding of the biology of neurons and synapses is a prerequisite to uncover the mechanisms involved in memory formation and the coordination of movement as well as their alterations occurring in several neurological disorders.展开更多
Prof.Yun Zhang was born on 9 July 1963 in Kunming,Yunnan,China,during a tumultuous period which he often referenced.Throughout his life,he harbored a steadfast belief in using knowledge to unravel the mysteries of hum...Prof.Yun Zhang was born on 9 July 1963 in Kunming,Yunnan,China,during a tumultuous period which he often referenced.Throughout his life,he harbored a steadfast belief in using knowledge to unravel the mysteries of human diseases.His educational journey was marked by frequent changes in schools due to his parents’occupational relocations.However,despite these challenges,he consistently displayed diligence and was admitted to the East China University of Science and Technology,Shanghai,after completing high school in 1980.He remained an active and loyal member of the School of Biotechnology at the university.展开更多
For the deep understanding on combustion of ammonia/diesel,this study develops a reduced mechanism of ammonia/diesel with 227 species and 937 reactions.The sub-mechanism on ammonia/interactions of N-based and C-based ...For the deep understanding on combustion of ammonia/diesel,this study develops a reduced mechanism of ammonia/diesel with 227 species and 937 reactions.The sub-mechanism on ammonia/interactions of N-based and C-based species(N—C)/NOx is optimized using the Non-dominated Sorting Genetic Algorithm II(NSGA-II)with 200 generations.The optimized mechanism(named as 937b)is validated against combustion characteristics of ammonia/methane(which is used to examine the accuracy of N—C interactions)and ammonia/diesel blends.The ignition delay times(IDTs),the laminar flame speeds and most of key intermediate species during the combustion of ammonia/methane blends can be accurately simulated by 937b under a wide range of conditions.As for ammonia/diesel blends with various diesel energy fractions,reasonable predictions on the IDTs under pressures from 1.0 MPa to5.0 MPa as well as the laminar flame speeds are also achieved by 937b.In particular,with regard to the IDT simulations of ammonia/diesel blends,937b makes progress in both aspects of overall accuracy and computational efficiency,compared to a detailed ammonia/diesel mechanism.Further kinetic analysis reveals that the reaction pathway of ammonia during the combustion of ammonia/diesel blend mainly differs in the tendencies of oxygen additions to NH_2 and NH with different equivalence ratios.展开更多
Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar formation.These changes reduce cardiac contractility,resulting in heart failure,which causes a huge public hea...Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar formation.These changes reduce cardiac contractility,resulting in heart failure,which causes a huge public health burden.Military personnel,compared with civilians,is exposed to more stress,a risk factor for heart diseases,making cardiovascular health management and treatment innovation an important topic for military medicine.So far,medical intervention can slow down cardiovascular disease progression,but not yet induce heart regeneration.In the past decades,studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart injury.Insights have emerged from studies in animal models and early clinical trials.Clinical interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart disease.In this review,we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury.展开更多
The solubility of H_(2)S was measured in solutions of N-butyl-N-methylmorpholine acetate([Bmmorp][Ac])containing 20%-40%(mass)water at experimental temperatures ranged from 298.15 to 328.15 K and pressures up to 320 k...The solubility of H_(2)S was measured in solutions of N-butyl-N-methylmorpholine acetate([Bmmorp][Ac])containing 20%-40%(mass)water at experimental temperatures ranged from 298.15 to 328.15 K and pressures up to 320 k Pa.The total solubility of H_(2)S increased with higher temperatures,lower pressures,and reduced water content.The reaction equilibrium thermodynamic model was used to correlate the solubility data.The results indicate that the chemical reaction equilibrium constant decrease with increasing water content and temperature,whereas Henry constant increase with increasing water content and temperature.Compared with other ionic liquids,H_(2)S exhibits a higher physical absorption enthalpy and a lower chemical absorption enthalpy in[Bmmorp][Ac]aqueous solution.This suggests that[Bmmorp][Ac]has a strong physical affinity for H_(2)S and low energy requirement for desorption.Quantum chemical methods were used to investigate the molecular mechanism of H_(2)S absorption in ionic liquids.The interaction energy analysis revealed that the binding of H_(2)S with the ionic liquid in a1:2 ratio is more stable.Detailed analyses by the methods of the interaction region indicator and the atoms in molecules were conducted to the interactions between H_(2)S and the ionic liquid.展开更多
文摘With the development and widespread use of blockchain in recent years,many projects have introduced blockchain technology to solve the growing security issues of the Industrial Internet of Things(IIoT).However,due to the conflict between the operational performance and security of the blockchain system and the compatibility issues with a large number of IIoT devices running together,the mainstream blockchain system cannot be applied to IIoT scenarios.In order to solve these problems,this paper proposes SBFT(Speculative Byzantine Consensus Protocol),a flexible and scalable blockchain consensus mechanism for the Industrial Internet of Things.SBFT has a consensus process based on speculation,improving the throughput and consensus speed of blockchain systems and reducing communication overhead.In order to improve the compatibility and scalability of the blockchain system,we select some nodes to participate in the consensus,and these nodes have better performance in the network.Since multiple properties determine node performance,we abstract the node selection problem as a joint optimization problem and use Dueling Deep Q Learning(DQL)to solve it.Finally,we evaluate the performance of the scheme through simulation,and the simulation results prove the superiority of our scheme.
文摘The wide application of intelligent terminals in microgrids has fueled the surge of data amount in recent years.In real-world scenarios,microgrids must store large amounts of data efficiently while also being able to withstand malicious cyberattacks.To meet the high hardware resource requirements,address the vulnerability to network attacks and poor reliability in the tradi-tional centralized data storage schemes,this paper proposes a secure storage management method for microgrid data that considers node trust and directed acyclic graph(DAG)consensus mechanism.Firstly,the microgrid data storage model is designed based on the edge computing technology.The blockchain,deployed on the edge computing server and combined with cloud storage,ensures reliable data storage in the microgrid.Secondly,a blockchain consen-sus algorithm based on directed acyclic graph data structure is then proposed to effectively improve the data storage timeliness and avoid disadvantages in traditional blockchain topology such as long chain construction time and low consensus efficiency.Finally,considering the tolerance differences among the candidate chain-building nodes to network attacks,a hash value update mechanism of blockchain header with node trust identification to ensure data storage security is proposed.Experimental results from the microgrid data storage platform show that the proposed method can achieve a private key update time of less than 5 milliseconds.When the number of blockchain nodes is less than 25,the blockchain construction takes no more than 80 mins,and the data throughput is close to 300 kbps.Compared with the traditional chain-topology-based consensus methods that do not consider node trust,the proposed method has higher efficiency in data storage and better resistance to network attacks.
基金funded in part by the National Natural Science Foundation of China (Grant no. 61772352, 62172061, 61871422)National Key Research and Development Project (Grants nos. 2020YFB1711800 and 2020YFB1707900)+2 种基金the Science and Technology Project of Sichuan Province (Grants no. 2021YFG0152, 2021YFG0025, 2020YFG0479, 2020YFG0322, 2020GFW035, 2020GFW033, 2020YFH0071)the R&D Project of Chengdu City (Grant no. 2019-YF05-01790-GX)the Central Universities of Southwest Minzu University (Grants no. ZYN2022032)
文摘In LEO(Low Earth Orbit)satellite communication systems,the satellite network is made up of a large number of satellites,the dynamically changing network environment affects the results of distributed computing.In order to improve the fault tolerance rate,a novel public blockchain consensus mechanism that applies a distributed computing architecture in a public network is proposed.Redundant calculation of blockchain ensures the credibility of the results;and the transactions with calculation results of a task are stored distributed in sequence in Directed Acyclic Graphs(DAG).The transactions issued by nodes are connected to form a net.The net can quickly provide node reputation evaluation that does not rely on third parties.Simulations show that our proposed blockchain has the following advantages:1.The task processing speed of the blockchain can be close to that of the fastest node in the entire blockchain;2.When the tasks’arrival time intervals and demanded working nodes(WNs)meet certain conditions,the network can tolerate more than 50%of malicious devices;3.No matter the number of nodes in the blockchain is increased or reduced,the network can keep robustness by adjusting the task’s arrival time interval and demanded WNs.
基金This work is supported by the Key Research and Development Project of Sichuan Province(No.2021YFSY0012,No.2020YFG0307,No.2021YFG0332)the Key Research and Development Project of Chengdu(No.2019-YF05-02028-GX)+1 种基金the Innovation Team of Quantum Security Communication of Sichuan Province(No.17TD0009)the Academic and Technical Leaders Training Funding Support Projects of Sichuan Province(No.2016120080102643).
文摘In recent years,Blockchain is gaining prominence as a hot topic in academic research.However,the consensus mechanism of blockchain has been criticized in terms of energy consumption and performance.Although Proof-of-Authority(PoA)consensus mechanism,as a lightweight consensus mechanism,is more efficient than traditional Proof-of-Work(PoW)and Proof-of-Stake(PoS),it suffers from the problem of centralization.To this end,on account of analyzing the shortcomings of existing consensus mechanisms,this paper proposes a dynamic reputation-based consensus mechanism for blockchain.This scheme allows nodes with reputation value higher than a threshold apply to become a monitoring node,which can monitor the behavior of validators in case that validators with excessive power cause harm to the blockchain network.At the same time,the reputation evaluation algorithm is also introduced to select nodes with high reputation to become validators in the network,thus increasing the cost of malicious behavior.In each consensus cycle,validators and monitoring nodes are dynamically updated according to the reputation value.Through security analysis,it is demonstrated that the scheme can resist the attacks of malicious nodes in the blockchain network.By simulation experiments and analysis of the scheme,the result verifies that the mechanism can effectively improve the fault tolerance of the consensus mechanism,reduce the time of consensus to guarantee the security of the system.
基金This work was supported by National Natural Science Foundation of China(Grant No.62162022 and 62162024)Key Projects in Hainan Province(Grant ZDYF2021GXJS003 and Grant ZDYF2020040)the Major science and technology project of Hainan Province(Grant No.ZDKJ2020012).
文摘The research on the governing blockchain by blockchain supervision system is an important development trend of blockchain technology.In this system there is a supervisory blockchain managing and governing the supervised blockchain based on blockchain technology,results in a uniquely cross-blockchain demand to consensus mechanism for solving the trust problem between supervisory blockchain and supervised blockchain.To solve this problem,this paper proposes a cross-blockchain consensus mechanism based on smart contract and a set of smart contracts endorse the crossblockchain consensus.New consensus mechanism called Proof-of-EndorseContracts(PoEC)consensus,which firstly transfers the consensus reached in supervisory blockchain to supervised blockchain by supervisory nodes,then packages the supervisory block in supervisory blockchain and transmits it to the smart contract deployed in the supervised blockchain,finally miners in supervised blockchain will execute and package the new block according to the status of the smart contract.The core part of the consensus mechanism is Endorse Contracts which designed and implemented by us and verified the effectiveness through experiments.PoEC consensus mechanism and Endorse Contracts support the supervised blockchain to join the governing blockchain by blockchain system without changing the original consensus mechanism,which has the advantages of low cost,high scalability and being able to crossblockchain.This paper proves that our method can provide a feasible crossblockchain governance scheme for the field of blockchain governance.
基金sponsored by the National Natural Science Foundation of China Nos.62172353,62302114 and U20B2046Future Network Scientific Research Fund Project No.FNSRFP-2021-YB-48Innovation Fund Program of the Engineering Research Center for Integration and Application of Digital Learning Technology of Ministry of Education No.1221045。
文摘Bitcoin is widely used as the most classic electronic currency for various electronic services such as exchanges,gambling,marketplaces,and also scams such as high-yield investment projects.Identifying the services operated by a Bitcoin address can help determine the risk level of that address and build an alert model accordingly.Feature engineering can also be used to flesh out labeled addresses and to analyze the current state of Bitcoin in a small way.In this paper,we address the problem of identifying multiple classes of Bitcoin services,and for the poor classification of individual addresses that do not have significant features,we propose a Bitcoin address identification scheme based on joint multi-model prediction using the mapping relationship between addresses and entities.The innovation of the method is to(1)Extract as many valuable features as possible when an address is given to facilitate the multi-class service identification task.(2)Unlike the general supervised model approach,this paper proposes a joint prediction scheme for multiple learners based on address-entity mapping relationships.Specifically,after obtaining the overall features,the address classification and entity clustering tasks are performed separately,and the results are subjected to graph-basedmaximization consensus.The final result ismade to baseline the individual address classification results while satisfying the constraint of having similarly behaving entities as far as possible.By testing and evaluating over 26,000 Bitcoin addresses,our feature extraction method captures more useful features.In addition,the combined multi-learner model obtained results that exceeded the baseline classifier reaching an accuracy of 77.4%.
基金This work was supported by the Chongqing Research Program of Basic Research and Frontier Technology(Grant No.cstc2021jcyj-msxmX0530 and Grant No.cstc2020jcyj-msxmX0804)the Graduate Scientific Research and Innovation Foundation of Chongqing(Grant No.CYS22457)+1 种基金the Technology Innovation and Application Development Projects of Chongqing(Grant No.cstc2021jscx-gksbX0032,cstc2021jscx-gksbX0029)the Key R&D plan of Hainan Province(Grant No.ZDYF2021GXJS006).
文摘Purpose-As the core technology of blockchain,various consensus mechanisms have emerged to satisfy the demands of different application scenarios.Since determining the security,scalability and other related performance of the blockchain,how to reach consensus efficiently of consensus mechanism is a critical issue in the blockchain.Design/methodology/approach-The paper opted for a research overview on the blockchain consensus mechanism,including the consensus mechanisms’consensus progress,classification and comparison,which are complemented by documentary analysis.Findings-This survey analyzes solutions for the improvement of consensus mechanisms in blockchain that have been proposed during the last few years and suggests future research directions around consensus mechanisms.First,the authors outline the consensus processes,the advantages and disadvantages of the mainstream consensus mechanisms.Additionally,the consensus mechanisms are subdivided into four types according to their characteristics.Then,the consensus mechanisms are compared and analyzed based on four evaluation criteria.Finally,the authors summarize the representative progress of consensus mechanisms and provide some suggestions on the design of consensus mechanisms to make further advances in this field.Originality/value-This paper summarizes the future research development of the consensus mechanisms.
基金supported by Henan University Science and Technology Innovation Talent Support Program(23HASTIT029)the National Natural Science Foundation of China(61902447)+3 种基金Tianjin Natural Science Foundation Key Project(22JCZDJC00600)Research Project of Humanities and Social Sciences in Universities of Henan Province(2024-ZDJH-061)Key Scientific Research Projects of Colleges and Universities in Henan Province(23A520054)Henan Science and Technology Research Project(232102210124).
文摘Effectively identifying and preventing the threat of Byzantine nodes to the security of distributed systems is a challenge in applying consortium chains.Therefore,this paper proposes a new consortium chain generation model,deeply analyzes the vulnerability of the consortium chain consensus based on the behavior of the nodes,and points out the effects of Byzantine node proportion and node state verification on the consensus process and system security.Furthermore,the normalized verification node aggregation index that represents the consensus ability of the consortium organization and the trust evaluation function of the verification node set is derived.When either of the two is lower than the threshold,the consortium institution or the verification node set members are dynamically adjusted.On this basis,an innovative consortium chain generation mechanism based on the Asynchronous Binary Byzantine Consensus Mechanism(ABBCM)is proposed.Based on the extended consortium chain consensus mechanism,a certain consensus value set can be combined into multiple proposals,which can realize crossdomain asynchronous message passing between multi-consortium chains without reducing the system’s security.In addition,experiments are carried out under four classical Byzantine Attack(BA)behaviors,BA1 to BA4.The results show that the proposed method can obtain better delay than the classical random Byzantine consensus algorithm Coin,effectively improving the consensus efficiency based on asynchronous message passing in the consortium chain and thus meeting the throughput of most Internet of Things(IoT)applications.
基金funded by the Ministry of Education,Culture,Research,and Technology(Kemendikbudristek)of Indonesia under PDD Grant with Grant Number NKB1016/UN2.RST/HKP.05.00/2022.
文摘This research presents a reputation-based blockchain consensus mechanism called Proof of Intelligent Reputation(PoIR)as an alternative to traditional Proof of Work(PoW).PoIR addresses the limitations of existing reputationbased consensus mechanisms by proposing a more decentralized and fair node selection process.The proposed PoIR consensus combines Bidirectional Long Short-Term Memory(BiLSTM)with the Network Entity Reputation Database(NERD)to generate reputation scores for network entities and select authoritative nodes.NERD records network entity profiles based on various sources,i.e.,Warden,Blacklists,DShield,AlienVault Open Threat Exchange(OTX),and MISP(Malware Information Sharing Platform).It summarizes these profile records into a reputation score value.The PoIR consensus mechanism utilizes these reputation scores to select authoritative nodes.The evaluation demonstrates that PoIR exhibits higher centralization resistance than PoS and PoW.Authoritative nodes were selected fairly during the 1000-block proposal round,ensuring a more decentralized blockchain ecosystem.In contrast,malicious nodes successfully monopolized 58%and 32%of transaction processes in PoS and PoW,respectively,but failed to do so in PoIR.The findings also indicate that PoIR offers efficient transaction times of 12 s,outperforms reputation-based consensus such as PoW,and is comparable to reputation-based consensus such as PoS.Furthermore,the model evaluation shows that BiLSTM outperforms other Recurrent Neural Network models,i.e.,BiGRU(Bidirectional Gated Recurrent Unit),UniLSTM(Unidirectional Long Short-Term Memory),and UniGRU(Unidirectional Gated Recurrent Unit)with 0.022 Root Mean Squared Error(RMSE).This study concludes that the PoIR consensus mechanism is more resistant to centralization than PoS and PoW.Integrating BiLSTM and NERD enhances the fairness and efficiency of blockchain applications.
基金supported by the National Natural Science Foundation of China (Nos.62172051,61772085,and 61877005)Jiangsu Agriculture Science and Technology Innovation Fund (No.CX (18)3054).
文摘As the smart grid develops rapidly,abundant connected devices offer various trading data.This raises higher requirements for secure and effective data storage.Traditional centralized data management does not meet the above requirements.Currently,smart grid with conventional consortium blockchain can solve the above issues.However,in the face of a large number of nodes,existing consensus algorithms often perform poorly in terms of efficiency and throughput.In this paper,we propose a trust-based hierarchical consensus mechanism(THCM)to solve this problem.Firstly,we design a hierarchical mechanism to improve the efficiency and throughput.Then,intra-layer nodes use an improved Raft consensus algorithm and inter-layer nodes use the Byzantine Fault Tolerance algorithm.Thirdly,we propose a trust evaluation method to improve the election process of Raft.Finally,we implement a prototype system to evaluate the performance of THCM.The results demonstrate that the consensus efficiency is improved by 19.8%,the throughput is improved by 12.34%,and the storage is reduced by 37.9%.
基金supported in part by the National Natural Science Foundation of China(51939001,61976033,62273072)the Natural Science Foundation of Sichuan Province (2022NSFSC0903)。
文摘This paper investigates the consensus control of multi-agent systems(MASs) with constrained input using the dynamic event-triggered mechanism(ETM).Consider the MASs with small-scale networks where a centralized dynamic ETM with global information of the MASs is first designed.Then,a distributed dynamic ETM which only uses local information is developed for the MASs with large-scale networks.It is shown that the semi-global consensus of the MASs can be achieved by the designed bounded control protocol where the Zeno phenomenon is eliminated by a designable minimum inter-event time.In addition,it is easier to find a trade-off between the convergence rate and the minimum inter-event time by an adjustable parameter.Furthermore,the results are extended to regional consensus of the MASs with the bounded control protocol.Numerical simulations show the effectiveness of the proposed approach.
基金supported by National Natural Science Foundation of China(31972021)R&D Projects in Key Areas of Guangdong Province(2019B020212003)+4 种基金the Science and Technology Program of Guangzhou,China(202206010177)Guangdong key research and development program(2021B0202060001)Foshan and agricultural academy cooperation projectGuangdong Modern Agriculture project(2022KJ117)Aquatic Products Center Project of GAAS。
文摘Escherichia coli O157:H7 is one of the major foodborne pathogenic bacterial that cause infectious diseases in humans.The previous found that a combination of kojic acid and tea polyphenols exhibited better activity against E.coli O157:H7 than using either alone.This study aimed to explore responses underlying the antibacterial mechanisms of kojic acid and tea polyphenols from the gene level.The functional enrichment analysis by comparing kojic acid and tea polyphenols individually or synergistically against E.coli O157:H7 found that acid resistance systems in kojic acid were activated,and the cell membrane and genomic DNA were destructed in the cells,resulting in“oxygen starvation”.The oxidative stress response triggered by tea polyphenols inhibited both sulfur uptake and the synthesis of ATP,which affected the bacteria's life metabolic process.Interestingly,we found that kojic acid combined with tea polyphenols hindered the uptake of iron that played an essential role in the synthesis of DNA,respiration,tricarboxylic acid cycle.The results suggested that the iron uptake pathways may represent a novel approach for kojic acid and tea polyphenols synergistically against E.coli O157:H7 and provided a theoretical basis for bacterial pathogen control in the food industry.
基金supported in part by the National Natural Science Foundation of China (NSFC)(61703086, 61773106)the IAPI Fundamental Research Funds (2018ZCX27)
文摘This paper is concerned with consensus of a secondorder linear time-invariant multi-agent system in the situation that there exists a communication delay among the agents in the network.A proportional-integral consensus protocol is designed by using delayed and memorized state information.Under the proportional-integral consensus protocol,the consensus problem of the multi-agent system is transformed into the problem of asymptotic stability of the corresponding linear time-invariant time-delay system.Note that the location of the eigenvalues of the corresponding characteristic function of the linear time-invariant time-delay system not only determines the stability of the system,but also plays a critical role in the dynamic performance of the system.In this paper,based on recent results on the distribution of roots of quasi-polynomials,several necessary conditions for Hurwitz stability for a class of quasi-polynomials are first derived.Then allowable regions of consensus protocol parameters are estimated.Some necessary and sufficient conditions for determining effective protocol parameters are provided.The designed protocol can achieve consensus and improve the dynamic performance of the second-order multi-agent system.Moreover,the effects of delays on consensus of systems of harmonic oscillators/double integrators under proportional-integral consensus protocols are investigated.Furthermore,some results on proportional-integral consensus are derived for a class of high-order linear time-invariant multi-agent systems.
基金National Natural Science Foundation of China(No.52178393)2023 High-level Talent Research Project from Yancheng Institute of Technology(No.xjr2023019)+1 种基金Open Fund Project of Shaanxi Key Laboratory of Geotechnical and Underground Space Engineering(Grant No.YT202302)Science and Technology Innovation Team of Shaanxi Innovation Capability Support Plan(No.2020TD005).
文摘The deformation in sedimentary rock induced by train loads has potential threat to the safe operation of tunnels. This study investigated the influence of stratification structure on the infrared radiation and temporal damage mechanism of hard siltstone. The uniaxial compression tests, coupled with acoustic emission(AE) and infrared radiation temperature(IRT) were conducted on siltstones with different stratification effects. The results revealed that the stratigraphic structure significantly affects the stress-strain response and strength degradation characteristics. The mechanical parameters exhibit anisotropy characteristics, and the stratification effect exhibits a negative correlation with the cracking stress and peak stress. The failure modes caused by the stratification effect show remarkable anisotropic features, including splitting failure(Ⅰ: 0°-22.50°, Ⅱ: 90°), composite failure(45°), and shearing failure(67.50°). The AE temporal sequences demonstrate a stepwise response characteristic to the loading stress level. The AE intensity indicates that the stress sensitivity of shearing failure and composite failure is generally greater than that of splitting failure. The IRT field has spatiotemporal migration and progressive dissimilation with stress loading and its dissimilation degree increases under higher stress levels. The stronger the stratification effect, the greater the dissimilation degree of the IRT field. The abnormal characteristic points of average infrared radiation temperature(AIRT) variance at local stress drop and peak stress can be used as early and late precursors to identify fracture instability. Theoretical analysis shows that the competitive relationship between compaction strengthening and fracturing damage intensifies the dissimilation of the infrared thermal field for an increasing stress level. The present study provides a theoretical reference for disaster warnings in hard sedimentary rock mass.
基金funding support from Natural Science Foundation of Shandong Province(Grant No.ZR2021QE187).
文摘Understanding the mechanical properties and multiscale failure mechanism of frozen soft rock is an important prerequisite for the construction safety of tunnels,artificially frozen ground and other infrastructure in cold regions.In this study,the triaxial compression test are performed on mudstone in the weakly cemented soft rock strata in the mining area of western China,and the mechanical characteristics and failure mechanism of weakly cemented mudstone are systematically investigated under the combined action of freezing and loading.Furthermore,the quantitative relationship between the microstructural parameters and the macroscopic strength and deformation parameters is established based on fractal theory.Thus,the failure mechanism of frozen weakly cemented mudstone is revealed on both micro- and macro-scales.The results show that temperature and confining pressure significantly affects the elastic modulus and peak strength of weakly cemented mudstone.With decreasing temperature,the compressive strength increases,while the corresponding peak strain decreases gradually.On the deformation curve,the plastic deformation stage is shortened,and the brittle fracture feature at the post-peak stage is more prominent,and the elastic modulus correspondingly increases with decreasing temperature.Under low-temperature conditions,most of the weakly cemented mudstone undergoes microscopic shear failure along the main fracture surface.The micro-fracture morphology characteristics of weakly cemented mudstone under different temperatures are quantified via the fractal dimension,and an approximately exponential relationship can be obtained among the fractal dimension and the temperature,compressive strength and elastic modulus.
基金supported by a grant from the Institut Professeur Baulieu (to DT)。
文摘The study of the brain and its complex functions is highly fascinating and,at the same time,extremely important.Indeed,furthering our understanding of the biology of neurons and synapses is a prerequisite to uncover the mechanisms involved in memory formation and the coordination of movement as well as their alterations occurring in several neurological disorders.
文摘Prof.Yun Zhang was born on 9 July 1963 in Kunming,Yunnan,China,during a tumultuous period which he often referenced.Throughout his life,he harbored a steadfast belief in using knowledge to unravel the mysteries of human diseases.His educational journey was marked by frequent changes in schools due to his parents’occupational relocations.However,despite these challenges,he consistently displayed diligence and was admitted to the East China University of Science and Technology,Shanghai,after completing high school in 1980.He remained an active and loyal member of the School of Biotechnology at the university.
基金the National Natural Science Foundation of China(project code:52202470)Jilin Province Natural Science Foundation(project codes:20220101205JC,20220101212JC)+2 种基金Jilin Province Specific Project of Industrial Technology Research&Development(project code:2020C025-2)2021 Interdisciplinary Integration and Innovation Project of Jilin University(project code:XJRCYB07)Free Exploration Project of Changsha Automotive Innovation Research Institute of Jilin University(project code:CAIRIZT20220202)。
文摘For the deep understanding on combustion of ammonia/diesel,this study develops a reduced mechanism of ammonia/diesel with 227 species and 937 reactions.The sub-mechanism on ammonia/interactions of N-based and C-based species(N—C)/NOx is optimized using the Non-dominated Sorting Genetic Algorithm II(NSGA-II)with 200 generations.The optimized mechanism(named as 937b)is validated against combustion characteristics of ammonia/methane(which is used to examine the accuracy of N—C interactions)and ammonia/diesel blends.The ignition delay times(IDTs),the laminar flame speeds and most of key intermediate species during the combustion of ammonia/methane blends can be accurately simulated by 937b under a wide range of conditions.As for ammonia/diesel blends with various diesel energy fractions,reasonable predictions on the IDTs under pressures from 1.0 MPa to5.0 MPa as well as the laminar flame speeds are also achieved by 937b.In particular,with regard to the IDT simulations of ammonia/diesel blends,937b makes progress in both aspects of overall accuracy and computational efficiency,compared to a detailed ammonia/diesel mechanism.Further kinetic analysis reveals that the reaction pathway of ammonia during the combustion of ammonia/diesel blend mainly differs in the tendencies of oxygen additions to NH_2 and NH with different equivalence ratios.
基金supported by the Natural Science Foundation of Beijing,China(7214223,7212027)the Beijing Hospitals Authority Youth Programme(QML20210601)+3 种基金the Chinese Scholarship Council(CSC)scholarship(201706210415)the National Key Research and Development Program of China(2017YFC0908800)the Beijing Municipal Health Commission(PXM2020_026272_000002,PXM2020_026272_000014)the National Natural Science Foundation of China(82070293).
文摘Heart injury such as myocardial infarction leads to cardiomyocyte loss,fibrotic tissue deposition,and scar formation.These changes reduce cardiac contractility,resulting in heart failure,which causes a huge public health burden.Military personnel,compared with civilians,is exposed to more stress,a risk factor for heart diseases,making cardiovascular health management and treatment innovation an important topic for military medicine.So far,medical intervention can slow down cardiovascular disease progression,but not yet induce heart regeneration.In the past decades,studies have focused on mechanisms underlying the regenerative capability of the heart and applicable approaches to reverse heart injury.Insights have emerged from studies in animal models and early clinical trials.Clinical interventions show the potential to reduce scar formation and enhance cardiomyocyte proliferation that counteracts the pathogenesis of heart disease.In this review,we discuss the signaling events controlling the regeneration of heart tissue and summarize current therapeutic approaches to promote heart regeneration after injury.
基金Financial support from the National Natural Science Foundation of China(21775081)Shandong Province Natural Science Foundation(ZR2020MB145)。
文摘The solubility of H_(2)S was measured in solutions of N-butyl-N-methylmorpholine acetate([Bmmorp][Ac])containing 20%-40%(mass)water at experimental temperatures ranged from 298.15 to 328.15 K and pressures up to 320 k Pa.The total solubility of H_(2)S increased with higher temperatures,lower pressures,and reduced water content.The reaction equilibrium thermodynamic model was used to correlate the solubility data.The results indicate that the chemical reaction equilibrium constant decrease with increasing water content and temperature,whereas Henry constant increase with increasing water content and temperature.Compared with other ionic liquids,H_(2)S exhibits a higher physical absorption enthalpy and a lower chemical absorption enthalpy in[Bmmorp][Ac]aqueous solution.This suggests that[Bmmorp][Ac]has a strong physical affinity for H_(2)S and low energy requirement for desorption.Quantum chemical methods were used to investigate the molecular mechanism of H_(2)S absorption in ionic liquids.The interaction energy analysis revealed that the binding of H_(2)S with the ionic liquid in a1:2 ratio is more stable.Detailed analyses by the methods of the interaction region indicator and the atoms in molecules were conducted to the interactions between H_(2)S and the ionic liquid.
