Introduction: Orthostatic Hypotension (OH) is a frequent situation during consultation in hypertensive patients. The prevalence in the general population increases with age and it is recommended to systematically...Introduction: Orthostatic Hypotension (OH) is a frequent situation during consultation in hypertensive patients. The prevalence in the general population increases with age and it is recommended to systematically search for it in patients with multiple comorbidities. The objective of this study was to determine the prevalence of orthostatic hypotension;describe their socio- demographic profile, the various clinical and paraclinical aspects and the predisposing factors of orthostatic hypotension in treated hypertensives, controlled or not. Method: This was a descriptive cross-sectional study, from January 2 to June 30, 2022 in the cardiology department of the Ignace Deen National Hospital. Included in this study were all patients who presented with orthostatic hypotension under antihypertensive treatment, regardless of age and sex, and who agreed to participate in the study. The non-inclusion criteria were hypertensive patients without OH and those who had not agreed to participate in the study. Each patient had blood pressure and heart rate measured in the supine position at room temperature and with an empty bladder. Then the measurement is taken again three (3) minutes after the switch to orthostatism. We retained the diagnosis of OH if the SBP drops by at least 20 mmHg and/or the PAD by at least 10 mmHg three (3) min after the transition to orthostatism. Our data obtained were analyzed in the Epi-info 7.4.0 software. Results: During our study period, we investigated 385 presented with OH, 12.2%. The mean age of the patients was 60.83 years ± 10.01 years and hypertensive patients, 47 of whom the M/F sex ratio was 0.81. In our study, blood pressure was not controlled in 36.2% of our patients with a predominance of grade 3 hypertension, a rate of 55.32%. Renal failure, anemia, heart failure and stroke were the main comorbidities associated with the occurrence of HO. The most incriminated factors were age with a frequency of 74.47%, followed by obesity at 44.68% and diabetes at 27.66%. BP was normally controlled with a rate of 68.8% in treated hypertensive patients with OH. It is found much more in patients using triple therapy, a rate of 61.71%. Conclusion: The prevalence of OH is high in our department. It is found much more in patients using triple therapy. The most incriminated factors were age followed by obesity and diabetes.展开更多
Arsenic in drinking water is a worldwide health problem that is associated with cardiovascular disease, but the cause is currently unknown. In order to examine whether arsenic affects vasomotor tone in blood vessels, ...Arsenic in drinking water is a worldwide health problem that is associated with cardiovascular disease, but the cause is currently unknown. In order to examine whether arsenic affects vasomotor tone in blood vessels, we investigated the effect of arsenic on agonist-induced vasorelaxation and vasoconstriction using the isolated rat aortic rings in in vitro organ bath system. Treatment with inorganic arsenite (AsⅢ) inhibited acetylcholine-induced relaxation of aortic rings by inhibiting production of nitric oxide in endothelium.展开更多
Most of the existing literature on the emergence of new consumption and its essence is based on the discussion of micro consumption phenomena. This paper takes new consumption phenomena in the digital media-dominated ...Most of the existing literature on the emergence of new consumption and its essence is based on the discussion of micro consumption phenomena. This paper takes new consumption phenomena in the digital media-dominated polymedia environment as the object of study to review the theoretical history of “mediatization,” and explores new consumption’s emergence, essence, and related issues systematically through deductive reasoning. More specifically, this paper is to first interpret the mediatization theory and then analyze two dimensions(i.e., the formation of mediatized consumption and the resultant reinvention of practice rules) from the perspective of media affordances. On this basis, we conclude mediatized consumption’s essence, forms, and practice rules. This study indicates that new consumption is essentially mediatized consumption, which concerns “media-shaped consumption” and “consumption-shaped media,” and that new consumption has two representations;consumption-oriented media and banal consumption. Media affordances make new consumption fields human-oriented, connecting “people” and “things,” and are becoming a major contributor to the formation of mediatized consumption. Thus, the practice rules concerning “people, goods, and fields” in the new consumption sector are reinvented;the social interactions in the “middle region” are highlighted;the imaginative, narrative, and social characteristics of goods are emphasized;and the cross-field integration of consumption is realized.展开更多
<strong>Background:</strong> Erectile dysfunction, which is defined as difficult to attain and maintain an erectile function enough to permit sufficient sexual performance, is accepted to be a big problem ...<strong>Background:</strong> Erectile dysfunction, which is defined as difficult to attain and maintain an erectile function enough to permit sufficient sexual performance, is accepted to be a big problem especially among diabetic patients. <strong>Objective </strong>To assess the Magnitude and factors contributing to Erectile Dysfunction Among Diabetic men attending the diabetic clinic in Debre Tabor Comprehensive and Specialized hospital, North West Ethiopia. <strong>Methods:</strong> Hospital based cross-sectional study was conducted on 362 participants in Debre Tabor Comprehensive and Specialized Hospital from August - December 2020 using systematic random sampling technique. Data were analyzed with SPSS Version 23. Binary and multivariable logistic regressions were done to identify factors which were contributing to erectile dysfunction. P-value < 0.05 and the corresponding 95% CI of odds ratios were considered to declare the result as statistically significant. <strong>Results:</strong> Three hundred sixty-two diabetes patients participating in the study with the mean age being 44.4 ± 14.47 (range: 18 - 78) years were interviewed. The majority (59.7% with CI: 54.4:64.6) of the diabetes patients suffered from erectile dysfunction and 13.3% (95% CI 17.8% - 26.8%) were found to have severe erectile dysfunction. Bi-variable analysis showed duration of diabetes (>10 years), type of diabetes (type II), physical exercise, drinking alcohol, BMI, blood glucose, and blood pressure were associated with erectile dysfunction at 5% level (p ≤ 0.05). Multiple logistic regression analysis revealed that duration of diabetes 10 years (AOR = 6.2, 95% CI: 2.78 - 13.85, p = 0.001), co-existing hypertension (AOR: 3.59, 95% CI: 1.58 - 8.19, p = 0.002), physically inactive (AOR = 2.87, 95% CI: 1.53 - 8.31, p = 0.003), unsafe level alcohol intake (AOR: 3.09;95% CI 1.45 - 6.59*, p = 0.003) and raised blood glucose (AOR: 15.26, 95% CI: 7.82 - 29.77, p = 0.004) were independent risk factors but no association was found with other variables. <strong>Conclusion:</strong> The magnitude of erectile dysfunction in this study population was 59.7% and associated with the type of diabetes;duration of diabetic, physical exercise, alcohol drinking, increase in blood pressure, and elevated blood glucose level were independently correlated with erectile dysfunction.展开更多
With the rapid socio-economic development and urban expansion,land subsidence has emerged as a major environmental issue,impeding the high-quality development of the plain area in eastern Zhengzhou City,Henan Province...With the rapid socio-economic development and urban expansion,land subsidence has emerged as a major environmental issue,impeding the high-quality development of the plain area in eastern Zhengzhou City,Henan Province,China.However,effective prevention and control of land subsidence in this region have been challenging due to the lack of comprehensive surface deformations monitoring and the quantitative analysis of the factors driving these deformations.In order to accurately identify the dominant factor driving surface deformations in the study area,this study utilized the Persistent Scattered Interferometric Synthetic Aperture Radar(PS-InSAR)technique to acquire the spatio-temporal distribution of surface deformations from January 2018 to March 2020.The acquired data was verified using leveling data.Subsequently,GIS spatial analysis was employed to investigate the responses of surface deformations to the driving factors.The findings are as follows:Finally,the geographical detector model was utilized to quantify the contributions of the driving factors and reveal the mechanisms of their interactions.The findings are as follows:(1)Surface deformations in the study area are dominated by land subsidence,concentrated mainly in Zhongmu County,with a deformation rate of−12.5–−37.1 mm/a.In contrast,areas experiencing surface uplift are primarily located downtown,with deformation rates ranging from 0 mm to 8 mm;(2)Groundwater level,lithology,and urban construction exhibit strong spatial correlations with cumulative deformation amplitude;(3)Groundwater level of the second aquifer group is the primary driver of spatially stratified heterogeneity in surface deformations,with a contributive degree of 0.5328.The contributive degrees of driving factors are significantly enhanced through interactions.Groundwater level and the cohesive soil thickness in the second aquifer group show the strongest interactions in the study area.Their total contributive degree increases to 0.5722 after interactions,establishing them as the primary factors influencing surface deformation patterns in the study area.The results of this study can provide a theoretical basis and scientific support for precise prevention and control measures against land subsidence in the study area,as well as contributing to research on the underlying mechanisms.展开更多
Objective To evaluate the risk factors of myasthenic crisis (MC) after thymectomy for myasthenia gravis (MG) . Methods A retrospective study was conducted in 84 patients with MG from July 1995 to December 2009. The fo...Objective To evaluate the risk factors of myasthenic crisis (MC) after thymectomy for myasthenia gravis (MG) . Methods A retrospective study was conducted in 84 patients with MG from July 1995 to December 2009. The following factors were evaluated: sex,age,history of preoperative myasthenic crisis,Ossermen classification, steroid hormones use and anticholinesterase drugs before operation,operation methods,operation time,thymoma,展开更多
The analysis of company data useful for economic decisions,if not interpreted in an overall view of the company situation,can lead to wrong conclusions.This is the case when a company has to choose between several sal...The analysis of company data useful for economic decisions,if not interpreted in an overall view of the company situation,can lead to wrong conclusions.This is the case when a company has to choose between several sales options for one or more products in the presence of a limiting factor.The continuation of the investigation often denies the initial analysis.Not everything is as it appears,therefore,at the beginning of the deepening of the data useful for economic decisions.As it is well known,the choices of profitability concerning the planning of the sale of company products take place,at least in the majority of cases,through the determination of the contribution margin,i.e.the profitability margin connected to the individual goods/services sold by the companies(selling price net of variable costs).The contribution margin can be determined with four objectives:(1)Determination of the yield of the single product,net of variable costs only.In this case,the margin defines unitary,from net product yield to unitary contribution margin.(2)Determination of the return on total sales of an individual product,net of variable costs.In this hypothesis,reference is made to the first level(or gross)contribution margin.(3)Determination of the ability of the individual product to contribute to the coverage of fixed costs common to the company.This margin is determined net of special product variable and fixed costs.This aggregate is defined as a Level II(or semi-gross)margin.(4)Determination of the useful value in the planning choices in case of presence of scarce productive factors.In this case,it must identify the so-called unitary margin for low factor.Here we will only deal with the problem of the use of the contribution margin in the presence of rare factors.To complete the analysis,below are some very brief considerations regarding,respectively,the unitary,level I,and level II contribution margin in order to better understand where the problem of the most convenient choice of income is located in the event of the presence of rare production factors,especially in an environment characterized by a plurality of sales options.展开更多
Malnutrition is a major public health problem in Mali, along with the country’s political and security instability. We initiated this work with the objective of determining the frequency as well as the risk factors f...Malnutrition is a major public health problem in Mali, along with the country’s political and security instability. We initiated this work with the objective of determining the frequency as well as the risk factors favoring the occurrence of malnutrition in children aged 6</span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">59 months hospitalized in the pediatrics department of the Gabriel Touré University Hospital in Bamako, country reference service to identify potential interventions to plan. A cross-sectional study was carried out over a period of 4 months. A bivariate logistic regression analysis allowed us to identify risk factors with degree of significance if p</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> < </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">0.05. During the study period, 2888 children were hospitalized, including 348 aged 6 to 59 months, or a frequency of 12.04%. One in two children was malnourished, </span><i><span style="font-family:Verdana;">i</span></i></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><i><span style="font-family:Verdana;">.</span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><i><span style="font-family:Verdana;">e</span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">.</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> a frequency of 50%. It more frequently affected infants aged between 6 and 23 months with a frequency of 33.7%</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">,</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> with a hospital frequency of growth retardation which was 23% including 14.7% of severe form. The emaciation was 27% of which 18.7% </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">were</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"> severe form. The underweight was 42.2% with 31% in severe form. We found the diet inequality in all malnourished and non-malnourished children. A bivariate </span><span style="font-family:Verdana;">analysis showed that children with an out-of-school mother have a 2.4-fold risk of being malnourished (OR</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">=</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">2.425;CI</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">= 1.9</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">4.2;p</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">0.03).</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Also children from households with no stable income (non-salaried father) have twice the risk of children from a household with stable income (OR</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">= 2.120;IC</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">=</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">1.1 </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> 4.1;p</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">0.002). Finally, inappropriate nutrients (early introduction of food and early weaning) have been strongly associated with the occurrence of malnutrition. The prevalence of malnutrition reflects the way children eat. Emphasis should be placed on nutritional education and financial stability in households.展开更多
<b><span style="font-family:""><span style="font-family:Verdana;">Backg</span><span style="font-family:Verdana;">round</span></span></b&g...<b><span style="font-family:""><span style="font-family:Verdana;">Backg</span><span style="font-family:Verdana;">round</span></span></b><span style="font-family:Verdana;">: Anemia is</span><span style="font-family:""> </span><span style="font-family:Verdana;">one of the most</span><span style="font-family:""> </span><span style="font-family:Verdana;">occurring nutritional deficiency</span><span style="font-family:Verdana;"> problems in the world especially in Africa. It can be prevalent in women of reproductive age, particularly during pregnancy when it is often a contributory cause of maternal mortality. In our country Ethiopia, anemia prevalence is increased from 2011 to 2016 in all anemia categories</span><span style="font-family:Verdana;">. </span><span style="font-family:""><span style="font-family:Verdana;">Even though scarce information is known about the problem in Ethiopia and studies related to the problem are not available at Debre Tabor comprehensive and specialized hospitals. Hence, we aimed to assess the prevalence and factors associated with anemia among pregnant women who are attending antenatal care at Debre Tabor Comprehensive and specialized hospitals. </span><b><span style="font-family:Verdana;">Methods</span></b><b><span style="font-family:Verdana;">:</span></b><span style="font-family:Verdana;"> Institution</span></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">based cross-sectional study was conducted from October 15 to November 15, 2020, with a sample size of 232 pregnant women participants selected using a systematic random sampling method. Laboratory determination of hemoglobin level was done at Anti-natal care follow-up. The data was entered into Epi info Version 7.2 and exported to SPSSS version 23 for analysis. Descriptive statistics using frequency and other summary statistics w</span><span style="font-family:Verdana;">ere</span><span style="font-family:""><span style="font-family:Verdana;"> used to present the socio-demographic and clinical characteristics of women. Binary and multivariable logistic regression was done to identify factors associated with anemia using an odds ratio at 95% CI and p-value < 0.05 significance level. </span><b><span style="font-family:Verdana;">Result:</span></b><span style="font-family:Verdana;"> The magnitude of anemia showed that 12.9% with 95% CI (9.4% - 17.7%). The mean age of the participants was 33 years with a range of 18 - 39 years. Rural residency (AOR:</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">2.82;95% CI:</span><span style="font-family:""> </span><span style="font-family:Verdana;">1.02</span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:Verdana;">4.87,</span><span style="font-family:""> </span><span style="font-family:Verdana;">p-0.001), multi-parity were (AOR:</span><span style="font-family:""> </span><span style="font-family:Verdana;">3.12;95% CI:</span><span style="font-family:""> </span><span style="font-family:Verdana;">2.43</span><span style="font-family:""> </span><span style="font-family:Verdana;">- 7.56,</span><span style="font-family:""> </span><span style="font-family:Verdana;">p-0.045), previous malaria attack (AOR:</span><span style="font-family:""> </span><span style="font-family:Verdana;">1.91;95% CI:</span><span style="font-family:""> </span><span style="font-family:Verdana;">1.04</span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:Verdana;">4.88,</span><span style="font-family:""> </span><span style="font-family:Verdana;">p-0.023), and having history of abortion (AOR:</span><span style="font-family:""> </span><span style="font-family:Verdana;">2.10;95% CI:</span><span style="font-family:""> </span><span style="font-family:Verdana;">1.18</span><span style="font-family:""> </span><span style="font-family:Verdana;">- 6.79,</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">p-0.014) were factors associated to anemia in pregnancy. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> This study found a relatively high magnitude of anemia among pregnant women. Rural residency, multi</span></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">parity, previous malaria attack, and having a history of abortion were found to be independent predictors of anemia in pregnancy.展开更多
Although the slippage effect has been extensively studied,most of the previous studies focused on the impact of the slippage effect on apparent permeability within a low pore pressure range,resulting in the inability ...Although the slippage effect has been extensively studied,most of the previous studies focused on the impact of the slippage effect on apparent permeability within a low pore pressure range,resulting in the inability of matching the evolution of permeability in the remaining pressure range.In this paper,a new apparent permeability model that reveals the evolution of permeability under the combined action of effective stress and slippage in the full pore pressure range was proposed.In this model,both intrinsic permeability and slippage coefficient are stress dependent.Three experimental tests with pore pressure lower than 2 MPa and a test with pore pressure at about 10 MPa using cores from the same origin under constant confining stress and constant effective stress are conducted.By comparing experimental data and another apparent permeability model,we proved the fidelity of our newly developed model.Furthermore,the contribution factor of the slippage effect Rslip is used to determine the low pore pressure limit with significant slippage effect.Our results show that both narrow initial pore size and high effective stress increase the critical pore pressure.Finally,the evolutions of the slippage coefficient and the intrinsic permeability under different boundary conditions were analyzed.展开更多
In the analysis on economic growth factors, calculating the contribution rate of influencing factor to economic growth using the CES production function model is a common and important research field. The CES producti...In the analysis on economic growth factors, calculating the contribution rate of influencing factor to economic growth using the CES production function model is a common and important research field. The CES production function model has a variety of forms, and the superposition CES production function model proposed in the paper is a new model. With regard to the model's parameter estimation, the paper proposes a modified particle swarm optimization which has a fast convergence rate and a high precision. With regard to the calculation of factor contribution rate, the paper offers a new scientific calculation method with the superposition CES production function model. At last, the paper makes an empirical analysis on the contribution rate of Chinese economic growth factors and the result obtained consists with the reality.展开更多
Epidermal growth factor receptor (EGFR) is overexpressed in head and neck squamous-cell carcinoma (HNSCC) and its expression levels correlate with decreased patient survival. Nonetheless, therapies aiming at blocking ...Epidermal growth factor receptor (EGFR) is overexpressed in head and neck squamous-cell carcinoma (HNSCC) and its expression levels correlate with decreased patient survival. Nonetheless, therapies aiming at blocking EGFR has shown limited efficacy in a proportion of patients with HNSCC in clinical trials. Sok et al. in a recent paper (Clin Cancer Res, 2006, 12:5064-5073 ) attempted to ascertain whether it is due to mutation of EGFR. As the most common form of mutation of EGFR seen in several other types of cancer is a truncation mutation,展开更多
文摘Introduction: Orthostatic Hypotension (OH) is a frequent situation during consultation in hypertensive patients. The prevalence in the general population increases with age and it is recommended to systematically search for it in patients with multiple comorbidities. The objective of this study was to determine the prevalence of orthostatic hypotension;describe their socio- demographic profile, the various clinical and paraclinical aspects and the predisposing factors of orthostatic hypotension in treated hypertensives, controlled or not. Method: This was a descriptive cross-sectional study, from January 2 to June 30, 2022 in the cardiology department of the Ignace Deen National Hospital. Included in this study were all patients who presented with orthostatic hypotension under antihypertensive treatment, regardless of age and sex, and who agreed to participate in the study. The non-inclusion criteria were hypertensive patients without OH and those who had not agreed to participate in the study. Each patient had blood pressure and heart rate measured in the supine position at room temperature and with an empty bladder. Then the measurement is taken again three (3) minutes after the switch to orthostatism. We retained the diagnosis of OH if the SBP drops by at least 20 mmHg and/or the PAD by at least 10 mmHg three (3) min after the transition to orthostatism. Our data obtained were analyzed in the Epi-info 7.4.0 software. Results: During our study period, we investigated 385 presented with OH, 12.2%. The mean age of the patients was 60.83 years ± 10.01 years and hypertensive patients, 47 of whom the M/F sex ratio was 0.81. In our study, blood pressure was not controlled in 36.2% of our patients with a predominance of grade 3 hypertension, a rate of 55.32%. Renal failure, anemia, heart failure and stroke were the main comorbidities associated with the occurrence of HO. The most incriminated factors were age with a frequency of 74.47%, followed by obesity at 44.68% and diabetes at 27.66%. BP was normally controlled with a rate of 68.8% in treated hypertensive patients with OH. It is found much more in patients using triple therapy, a rate of 61.71%. Conclusion: The prevalence of OH is high in our department. It is found much more in patients using triple therapy. The most incriminated factors were age followed by obesity and diabetes.
文摘Arsenic in drinking water is a worldwide health problem that is associated with cardiovascular disease, but the cause is currently unknown. In order to examine whether arsenic affects vasomotor tone in blood vessels, we investigated the effect of arsenic on agonist-induced vasorelaxation and vasoconstriction using the isolated rat aortic rings in in vitro organ bath system. Treatment with inorganic arsenite (AsⅢ) inhibited acetylcholine-induced relaxation of aortic rings by inhibiting production of nitric oxide in endothelium.
基金a phased research result of the“New Changes in Media and New Consumerism”(18BXW085)a program funded by the National Social Science Fund of China(NSSFC)。
文摘Most of the existing literature on the emergence of new consumption and its essence is based on the discussion of micro consumption phenomena. This paper takes new consumption phenomena in the digital media-dominated polymedia environment as the object of study to review the theoretical history of “mediatization,” and explores new consumption’s emergence, essence, and related issues systematically through deductive reasoning. More specifically, this paper is to first interpret the mediatization theory and then analyze two dimensions(i.e., the formation of mediatized consumption and the resultant reinvention of practice rules) from the perspective of media affordances. On this basis, we conclude mediatized consumption’s essence, forms, and practice rules. This study indicates that new consumption is essentially mediatized consumption, which concerns “media-shaped consumption” and “consumption-shaped media,” and that new consumption has two representations;consumption-oriented media and banal consumption. Media affordances make new consumption fields human-oriented, connecting “people” and “things,” and are becoming a major contributor to the formation of mediatized consumption. Thus, the practice rules concerning “people, goods, and fields” in the new consumption sector are reinvented;the social interactions in the “middle region” are highlighted;the imaginative, narrative, and social characteristics of goods are emphasized;and the cross-field integration of consumption is realized.
文摘<strong>Background:</strong> Erectile dysfunction, which is defined as difficult to attain and maintain an erectile function enough to permit sufficient sexual performance, is accepted to be a big problem especially among diabetic patients. <strong>Objective </strong>To assess the Magnitude and factors contributing to Erectile Dysfunction Among Diabetic men attending the diabetic clinic in Debre Tabor Comprehensive and Specialized hospital, North West Ethiopia. <strong>Methods:</strong> Hospital based cross-sectional study was conducted on 362 participants in Debre Tabor Comprehensive and Specialized Hospital from August - December 2020 using systematic random sampling technique. Data were analyzed with SPSS Version 23. Binary and multivariable logistic regressions were done to identify factors which were contributing to erectile dysfunction. P-value < 0.05 and the corresponding 95% CI of odds ratios were considered to declare the result as statistically significant. <strong>Results:</strong> Three hundred sixty-two diabetes patients participating in the study with the mean age being 44.4 ± 14.47 (range: 18 - 78) years were interviewed. The majority (59.7% with CI: 54.4:64.6) of the diabetes patients suffered from erectile dysfunction and 13.3% (95% CI 17.8% - 26.8%) were found to have severe erectile dysfunction. Bi-variable analysis showed duration of diabetes (>10 years), type of diabetes (type II), physical exercise, drinking alcohol, BMI, blood glucose, and blood pressure were associated with erectile dysfunction at 5% level (p ≤ 0.05). Multiple logistic regression analysis revealed that duration of diabetes 10 years (AOR = 6.2, 95% CI: 2.78 - 13.85, p = 0.001), co-existing hypertension (AOR: 3.59, 95% CI: 1.58 - 8.19, p = 0.002), physically inactive (AOR = 2.87, 95% CI: 1.53 - 8.31, p = 0.003), unsafe level alcohol intake (AOR: 3.09;95% CI 1.45 - 6.59*, p = 0.003) and raised blood glucose (AOR: 15.26, 95% CI: 7.82 - 29.77, p = 0.004) were independent risk factors but no association was found with other variables. <strong>Conclusion:</strong> The magnitude of erectile dysfunction in this study population was 59.7% and associated with the type of diabetes;duration of diabetic, physical exercise, alcohol drinking, increase in blood pressure, and elevated blood glucose level were independently correlated with erectile dysfunction.
基金supported by the China Geological Survey Project(Grant No.DD20189262Grant No.DD20211309)Basic Research Operations Project of the Institute of Hydrogeology and Environmental Geology,Chinese Academy of Geological Sciences(SK202206).
文摘With the rapid socio-economic development and urban expansion,land subsidence has emerged as a major environmental issue,impeding the high-quality development of the plain area in eastern Zhengzhou City,Henan Province,China.However,effective prevention and control of land subsidence in this region have been challenging due to the lack of comprehensive surface deformations monitoring and the quantitative analysis of the factors driving these deformations.In order to accurately identify the dominant factor driving surface deformations in the study area,this study utilized the Persistent Scattered Interferometric Synthetic Aperture Radar(PS-InSAR)technique to acquire the spatio-temporal distribution of surface deformations from January 2018 to March 2020.The acquired data was verified using leveling data.Subsequently,GIS spatial analysis was employed to investigate the responses of surface deformations to the driving factors.The findings are as follows:Finally,the geographical detector model was utilized to quantify the contributions of the driving factors and reveal the mechanisms of their interactions.The findings are as follows:(1)Surface deformations in the study area are dominated by land subsidence,concentrated mainly in Zhongmu County,with a deformation rate of−12.5–−37.1 mm/a.In contrast,areas experiencing surface uplift are primarily located downtown,with deformation rates ranging from 0 mm to 8 mm;(2)Groundwater level,lithology,and urban construction exhibit strong spatial correlations with cumulative deformation amplitude;(3)Groundwater level of the second aquifer group is the primary driver of spatially stratified heterogeneity in surface deformations,with a contributive degree of 0.5328.The contributive degrees of driving factors are significantly enhanced through interactions.Groundwater level and the cohesive soil thickness in the second aquifer group show the strongest interactions in the study area.Their total contributive degree increases to 0.5722 after interactions,establishing them as the primary factors influencing surface deformation patterns in the study area.The results of this study can provide a theoretical basis and scientific support for precise prevention and control measures against land subsidence in the study area,as well as contributing to research on the underlying mechanisms.
文摘Objective To evaluate the risk factors of myasthenic crisis (MC) after thymectomy for myasthenia gravis (MG) . Methods A retrospective study was conducted in 84 patients with MG from July 1995 to December 2009. The following factors were evaluated: sex,age,history of preoperative myasthenic crisis,Ossermen classification, steroid hormones use and anticholinesterase drugs before operation,operation methods,operation time,thymoma,
文摘The analysis of company data useful for economic decisions,if not interpreted in an overall view of the company situation,can lead to wrong conclusions.This is the case when a company has to choose between several sales options for one or more products in the presence of a limiting factor.The continuation of the investigation often denies the initial analysis.Not everything is as it appears,therefore,at the beginning of the deepening of the data useful for economic decisions.As it is well known,the choices of profitability concerning the planning of the sale of company products take place,at least in the majority of cases,through the determination of the contribution margin,i.e.the profitability margin connected to the individual goods/services sold by the companies(selling price net of variable costs).The contribution margin can be determined with four objectives:(1)Determination of the yield of the single product,net of variable costs only.In this case,the margin defines unitary,from net product yield to unitary contribution margin.(2)Determination of the return on total sales of an individual product,net of variable costs.In this hypothesis,reference is made to the first level(or gross)contribution margin.(3)Determination of the ability of the individual product to contribute to the coverage of fixed costs common to the company.This margin is determined net of special product variable and fixed costs.This aggregate is defined as a Level II(or semi-gross)margin.(4)Determination of the useful value in the planning choices in case of presence of scarce productive factors.In this case,it must identify the so-called unitary margin for low factor.Here we will only deal with the problem of the use of the contribution margin in the presence of rare factors.To complete the analysis,below are some very brief considerations regarding,respectively,the unitary,level I,and level II contribution margin in order to better understand where the problem of the most convenient choice of income is located in the event of the presence of rare production factors,especially in an environment characterized by a plurality of sales options.
文摘Malnutrition is a major public health problem in Mali, along with the country’s political and security instability. We initiated this work with the objective of determining the frequency as well as the risk factors favoring the occurrence of malnutrition in children aged 6</span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">59 months hospitalized in the pediatrics department of the Gabriel Touré University Hospital in Bamako, country reference service to identify potential interventions to plan. A cross-sectional study was carried out over a period of 4 months. A bivariate logistic regression analysis allowed us to identify risk factors with degree of significance if p</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> < </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">0.05. During the study period, 2888 children were hospitalized, including 348 aged 6 to 59 months, or a frequency of 12.04%. One in two children was malnourished, </span><i><span style="font-family:Verdana;">i</span></i></span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><i><span style="font-family:Verdana;">.</span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><i><span style="font-family:Verdana;">e</span></i></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">.</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> a frequency of 50%. It more frequently affected infants aged between 6 and 23 months with a frequency of 33.7%</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">,</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> with a hospital frequency of growth retardation which was 23% including 14.7% of severe form. The emaciation was 27% of which 18.7% </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">were</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;"> severe form. The underweight was 42.2% with 31% in severe form. We found the diet inequality in all malnourished and non-malnourished children. A bivariate </span><span style="font-family:Verdana;">analysis showed that children with an out-of-school mother have a 2.4-fold risk of being malnourished (OR</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">=</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">2.425;CI</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">= 1.9</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">4.2;p</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">0.03).</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Also children from households with no stable income (non-salaried father) have twice the risk of children from a household with stable income (OR</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">= 2.120;IC</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">=</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">1.1 </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">-</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> 4.1;p</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"><</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">0.002). Finally, inappropriate nutrients (early introduction of food and early weaning) have been strongly associated with the occurrence of malnutrition. The prevalence of malnutrition reflects the way children eat. Emphasis should be placed on nutritional education and financial stability in households.
文摘<b><span style="font-family:""><span style="font-family:Verdana;">Backg</span><span style="font-family:Verdana;">round</span></span></b><span style="font-family:Verdana;">: Anemia is</span><span style="font-family:""> </span><span style="font-family:Verdana;">one of the most</span><span style="font-family:""> </span><span style="font-family:Verdana;">occurring nutritional deficiency</span><span style="font-family:Verdana;"> problems in the world especially in Africa. It can be prevalent in women of reproductive age, particularly during pregnancy when it is often a contributory cause of maternal mortality. In our country Ethiopia, anemia prevalence is increased from 2011 to 2016 in all anemia categories</span><span style="font-family:Verdana;">. </span><span style="font-family:""><span style="font-family:Verdana;">Even though scarce information is known about the problem in Ethiopia and studies related to the problem are not available at Debre Tabor comprehensive and specialized hospitals. Hence, we aimed to assess the prevalence and factors associated with anemia among pregnant women who are attending antenatal care at Debre Tabor Comprehensive and specialized hospitals. </span><b><span style="font-family:Verdana;">Methods</span></b><b><span style="font-family:Verdana;">:</span></b><span style="font-family:Verdana;"> Institution</span></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">based cross-sectional study was conducted from October 15 to November 15, 2020, with a sample size of 232 pregnant women participants selected using a systematic random sampling method. Laboratory determination of hemoglobin level was done at Anti-natal care follow-up. The data was entered into Epi info Version 7.2 and exported to SPSSS version 23 for analysis. Descriptive statistics using frequency and other summary statistics w</span><span style="font-family:Verdana;">ere</span><span style="font-family:""><span style="font-family:Verdana;"> used to present the socio-demographic and clinical characteristics of women. Binary and multivariable logistic regression was done to identify factors associated with anemia using an odds ratio at 95% CI and p-value < 0.05 significance level. </span><b><span style="font-family:Verdana;">Result:</span></b><span style="font-family:Verdana;"> The magnitude of anemia showed that 12.9% with 95% CI (9.4% - 17.7%). The mean age of the participants was 33 years with a range of 18 - 39 years. Rural residency (AOR:</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">2.82;95% CI:</span><span style="font-family:""> </span><span style="font-family:Verdana;">1.02</span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:Verdana;">4.87,</span><span style="font-family:""> </span><span style="font-family:Verdana;">p-0.001), multi-parity were (AOR:</span><span style="font-family:""> </span><span style="font-family:Verdana;">3.12;95% CI:</span><span style="font-family:""> </span><span style="font-family:Verdana;">2.43</span><span style="font-family:""> </span><span style="font-family:Verdana;">- 7.56,</span><span style="font-family:""> </span><span style="font-family:Verdana;">p-0.045), previous malaria attack (AOR:</span><span style="font-family:""> </span><span style="font-family:Verdana;">1.91;95% CI:</span><span style="font-family:""> </span><span style="font-family:Verdana;">1.04</span><span style="font-family:""> </span><span style="font-family:Verdana;">-</span><span style="font-family:""> </span><span style="font-family:Verdana;">4.88,</span><span style="font-family:""> </span><span style="font-family:Verdana;">p-0.023), and having history of abortion (AOR:</span><span style="font-family:""> </span><span style="font-family:Verdana;">2.10;95% CI:</span><span style="font-family:""> </span><span style="font-family:Verdana;">1.18</span><span style="font-family:""> </span><span style="font-family:Verdana;">- 6.79,</span><span style="font-family:""> </span><span style="font-family:""><span style="font-family:Verdana;">p-0.014) were factors associated to anemia in pregnancy. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> This study found a relatively high magnitude of anemia among pregnant women. Rural residency, multi</span></span><span style="font-family:Verdana;">-</span><span style="font-family:Verdana;">parity, previous malaria attack, and having a history of abortion were found to be independent predictors of anemia in pregnancy.
基金supported by the National Natural Science Foundation of China(No.52079077)the Natural Science Foundation of Shandong Province(No.ZR2021QE069)China Postdoctoral Science Foundation(No.2019M662402).
文摘Although the slippage effect has been extensively studied,most of the previous studies focused on the impact of the slippage effect on apparent permeability within a low pore pressure range,resulting in the inability of matching the evolution of permeability in the remaining pressure range.In this paper,a new apparent permeability model that reveals the evolution of permeability under the combined action of effective stress and slippage in the full pore pressure range was proposed.In this model,both intrinsic permeability and slippage coefficient are stress dependent.Three experimental tests with pore pressure lower than 2 MPa and a test with pore pressure at about 10 MPa using cores from the same origin under constant confining stress and constant effective stress are conducted.By comparing experimental data and another apparent permeability model,we proved the fidelity of our newly developed model.Furthermore,the contribution factor of the slippage effect Rslip is used to determine the low pore pressure limit with significant slippage effect.Our results show that both narrow initial pore size and high effective stress increase the critical pore pressure.Finally,the evolutions of the slippage coefficient and the intrinsic permeability under different boundary conditions were analyzed.
基金Supported by the National Natural Science Foundation of China(11401418)the National Statistical Research Program(2013LY133)Scientific Research Foundation of Suzhou University of Science and Technology(XKZ201309)
文摘In the analysis on economic growth factors, calculating the contribution rate of influencing factor to economic growth using the CES production function model is a common and important research field. The CES production function model has a variety of forms, and the superposition CES production function model proposed in the paper is a new model. With regard to the model's parameter estimation, the paper proposes a modified particle swarm optimization which has a fast convergence rate and a high precision. With regard to the calculation of factor contribution rate, the paper offers a new scientific calculation method with the superposition CES production function model. At last, the paper makes an empirical analysis on the contribution rate of Chinese economic growth factors and the result obtained consists with the reality.
文摘Epidermal growth factor receptor (EGFR) is overexpressed in head and neck squamous-cell carcinoma (HNSCC) and its expression levels correlate with decreased patient survival. Nonetheless, therapies aiming at blocking EGFR has shown limited efficacy in a proportion of patients with HNSCC in clinical trials. Sok et al. in a recent paper (Clin Cancer Res, 2006, 12:5064-5073 ) attempted to ascertain whether it is due to mutation of EGFR. As the most common form of mutation of EGFR seen in several other types of cancer is a truncation mutation,
