The main goal of English teaching in colleges and universities is to cultivate students’ability to use the language,but many students are still unable to complete oral communication fluently after years of study.For ...The main goal of English teaching in colleges and universities is to cultivate students’ability to use the language,but many students are still unable to complete oral communication fluently after years of study.For this reason,teachers need to deeply analyze and study the linguistic features of oral English corpora and formulate reasonable teaching strategies to improve students’oral expression skills.This paper outlines the linguistic features of oral English corpora,comparatively analyzes the differences between oral English corpora and written English corpora,and explores effective teaching strategies,hoping to provide guidelines for relevant teachers.展开更多
The present article provides a critical review of Randi Reppen's impressing book Using Corpora in the Language Classroom.It's argued that Randi Reppen's book,despite a few slight flaws,has a strong practic...The present article provides a critical review of Randi Reppen's impressing book Using Corpora in the Language Classroom.It's argued that Randi Reppen's book,despite a few slight flaws,has a strong practical orientation and is a laudable effort to make English language teachers to realize the importance and practicality of bringing corpora into classroom in digital age.The book is particularly worthy of reading for those language teachers(especially beginner teachers) who want to breathe new life into their English teaching.展开更多
This paper examines the application of electronic corpora to English classroom of lexical learning.It starts with a literature review of basic issues on corpus linguistics and theories underlying lexical study,followe...This paper examines the application of electronic corpora to English classroom of lexical learning.It starts with a literature review of basic issues on corpus linguistics and theories underlying lexical study,followed by discussion on the specific lexical learning aspects in which a corpus might provide some insight.Based other research like data-driven learning(DDL)in this area,the paper goes further by exploring the possibility and ways of applying corpora in vocabulary learning classroom.展开更多
The motivation for this research comes from the gap found in discovering the common ground for medical context learning through analytics for different purposes of diagnosing,recommending,prescribing,or treating patie...The motivation for this research comes from the gap found in discovering the common ground for medical context learning through analytics for different purposes of diagnosing,recommending,prescribing,or treating patients for uniform phenotype features from patients’profile.The authors of this paper while searching for possible solutions for medical context learning found that unified corpora tagged with medical nomenclature was missing to train the analytics for medical context learning.Therefore,here we demonstrated a mechanism to come up with uniform NER(Named Entity Recognition)tagged medical corpora that is fed with 14407 endocrine patients’data set in Comma Separated Values(CSV)format diagnosed with diabetes mellitus and comorbidity diseases.The other corpus is of ICD-10-CM coding scheme in text format taken from www.icd10data.com.ICD-10-CM corpus is to be tagged for understanding the medical context with uniformity for which we are conducting different experiments using common natural language programming(NLP)techniques and frameworks like TensorFlow,Keras,Long Short-Term Memory(LSTM),and Bi-LSTM.In our preliminary experiments,albeit label sets in form of(instance,label)pair were tagged with Sequential()model formed on TensorFlow.Keras and Bi-LSTM NLP algorithms.The maximum accuracy achieved for model validation was 0.8846.展开更多
In the present study,we aimed to investigate a protective role for resveratrol against the effects of immobilization stress on corpora lutea(CL)of mice in early pregnancy.A total of 45 early-pregnant mice were divided...In the present study,we aimed to investigate a protective role for resveratrol against the effects of immobilization stress on corpora lutea(CL)of mice in early pregnancy.A total of 45 early-pregnant mice were divided into no immobilization stress(NIS)group,immobilization stress(IS)group,and immobilization and resveratrol treatment(IS+RES)group(n=15).Mice were immobilized in plastic tubes(50 mL)for 3 h per day during day 1 to 7 of pregnancy.In the IS+RES group,5 mg kg-'d-1 of resveratrol was administered just prior to application of stress.We analyzed apoptotic activity in CL by Western botting analysis(WB),transmission electron microscopy(TEM),and immunohistochemistry(IHC).Serum progesterone levels were examined with radioimmunoassay(RIA).IHC results showed that the intensity of positive staining for Bax was increased,and for BcI-2 was decreased in CL after IS,while resveratrol treatment reversed the positive staining for Bax and Bcl-2.WB revealed that immobilization stress up-regulated the expression of Bax and caspase-9,and down-regulated Bcl-2 expression,while resveratrol treatment attenuated the effects of immobilization stress on the expression of Bax,Bcl-2 and caspase-9.According to our TEM results,apoptosis as defined by chromatin condensation was found in CL after immobilization stress,while resveratrol inhibited the apoptosis.We also demonstrated that immobilization stress decreased progesterone concentrations and ovarian expression of StAR,while resveratrol restored the concentrations of progesterone and expression of StAR back to normal.These results indicated that immobilization stress induced luteal regression while resveratrol inhibited luteal regression,suggesting that resveratrol plays a protective role on corpora lutea of mice during early pregnancy.展开更多
Digitalization has changed the way of information processing, and newtechniques of legal data processing are evolving. Text mining helps to analyze andsearch different court cases available in the form of digital text...Digitalization has changed the way of information processing, and newtechniques of legal data processing are evolving. Text mining helps to analyze andsearch different court cases available in the form of digital text documents toextract case reasoning and related data. This sort of case processing helps professionals and researchers to refer the previous case with more accuracy in reducedtime. The rapid development of judicial ontologies seems to deliver interestingproblem solving to legal knowledge formalization. Mining context informationthrough ontologies from corpora is a challenging and interesting field. Thisresearch paper presents a three tier contextual text mining framework throughontologies for judicial corpora. This framework comprises on the judicial corpus,text mining processing resources and ontologies for mining contextual text fromcorpora to make text and data mining more reliable and fast. A top-down ontologyconstruction approach has been adopted in this paper. The judicial corpus hasbeen selected with a sufficient dataset to process and evaluate the results.The experimental results and evaluations show significant improvements incomparison with the available techniques.展开更多
BACKGROUND: Insulin-like growth factor-I(IGF-1), as one of the important members of growth factor family, participants in the regulation of many physiological functions and behaviors, having very strong neuroprotectiv...BACKGROUND: Insulin-like growth factor-I(IGF-1), as one of the important members of growth factor family, participants in the regulation of many physiological functions and behaviors, having very strong neuroprotective effect. However, the expression of IGF-1 following cerebral ischemia/reperfusion is still disputed. OBJECTIVE: To observe the expression of IGF-1 and protein of corpora striata in ischemic side at the early stage of middle cerebral artery ischemia/reperfusion in rhesus monkey. DESIGN: A completely randomized grouping design, controlled animal experiment. SETTING: Institute of Cerebrovascular Disease, Affiliated Hospital of Medical College of Qingdao University. MATERIALS: ① Totally 17 rhesus monkeys , of either gender, aged 4 to 5 years, were enrolled . Seven rhesus monkeys observed with gene chip were randomly divided into 2 groups: sham operation group (n=3) and ischemia/reperfusion group (n=4). Ten rhesus monkeys observed with in situ hybridization and immunohistochemistry method were randomly divided into 2 groups: sham operation group (n=3)and ischemia/reperfusion group (n=7). Rhesus monkeys observed under microscope were divided into 2 groups: sham operation group (n=6) and ischamia/reperfusion group (n=11). ② Materials used in the experiment: cresyl violet (Sigma Company, America); immunohistochemical reagent kit ( Huamei Bio-engineering Company); In situ hybridization reagent kit (Boshide Bio-engineering Co.Ltd, Wuhan); 12 800 dots chip (Boxing Company, Shanghai). METHODS: This experiment was carried out at the Institute of Cerebrovascular Disease, Affiliated Hospital of Medical College of Qingdao University from January 2001 to December 2003. ① The onset area of middle cerebral artery was blocked for 2 hours, middle cerebral artery ischemia/reperfusion models were created. ② After ischemia/reperfusion for 24 hours, cerebral tissue sections of rhesus monkeys were prepared and stained with cresyl violet. Image analysis was performed with 500IW image analysis software. Morphological change of corpora striata of operative side was observed in the rhesus monkeys between two groups. Total RNA was extracted from cerebral tissue. ③ Detection of gene chip: Cy3-duTP and Cy5-duTP were used to respectively perform reverse transcription labeling. The sample was reversely transcribed into cDNA, then hybridized with cDNA of cerebral tissue. Genes with the separate absolute value of cy3 and cy5>800, cy3/cy5 > 2(high expression) or < 0.5 (low expression) were found out. Those were genes with differential expression. ④ The expressions of IGF-1 mRNA and protein level of corpora striata in ischemic side of rhesus monkeys were detected between sham operation group and ischemia/reperfusion group at 9 and 24 hours after ischemia/reperfusion with in situ hybridization method and immunohistochemical method. Brown granules were IGF-1 protein positive cells. ⑤ Analysis of variance was used in the difference comparison of measurement data among groups. MAIN OUTCOME MEASURES: ① Change of morphological structure of corpora striata at ischemic side in rhesus monkeys. ② Change of cerebral gene expression profiles at ischemia/reperfusion in rhesus monkeys between two groups. ③ Expression of IGF-1 mRNA and protein level of corpora striata at ischemia/reperfusion in rhesus monkeys between two groups. RESULTS: ① Pathological change : Obvious pathological change of cerebral infarction appeared in the ischemia and reperfusion group, while there was no such pathological change in the sham operation group. ② Change of gene expression profile : There were 4480 genes with difference expression in the ischemia/reperfusion group and sham-operation group, in which, 260 genes had high expression and their absolute value was over 800, and 63 genes had low expression. cy3/cy5 of IGF-1 was 0.379, being relative low expression. ③ IGF-1 mRNA and protein positive cell counts in corpora striata at cerebral ischemic side[IGF-1 mRNA:(9.72±1.18),(9.11±0.76),(14.77±0.60) counts/field;IGF-1 protein:(15.11±1.83),(15.39±0.78),(34.62±0.97)counts/field,P < 0.05-0.01]. CONCLUSION: IGF-1 mRNA and protein are lowly expressed in middle cerebral artery of rhesus monkeys at ischemia/reperfusion.展开更多
A novel visualized sound description, called sound dendrogram is proposed to make manual annotation easier when building large speech corpora. It is a lattice structure built from a group of “seed regions” and throu...A novel visualized sound description, called sound dendrogram is proposed to make manual annotation easier when building large speech corpora. It is a lattice structure built from a group of “seed regions” and through an iterative procedure of mergence. A simple but reliable extraction method of “seed regions” and advanced distance metric are adopted to construct the sound dendrogram, so that it can present speech’s structure character ranging from coarse to fine in a visualized way. Tests show that all phonemic boundaries are contained in the lattice structure of sound dendrogram and very easy to identify. Sound dendrogram can be a powerful assistant tool during the process of speech corpora’s manual annotation.展开更多
The rising of aging and the declining of birth rates have forced the public to focus on the youth’s view on marriage.Based on critical discourse analysis and combined with Fairclough’s three-dimensional discourse an...The rising of aging and the declining of birth rates have forced the public to focus on the youth’s view on marriage.Based on critical discourse analysis and combined with Fairclough’s three-dimensional discourse analysis model,this paper builds a“Chinese media News Report Corpus on the topic of‘marriage’”whose news are collected from China Daily.It is found that the discourses are neutral and objective with regard to the advantages and disadvantages of marriage,but in general,it is still a traditional view of marriage that is inevitable and closely related to fertility.Although this is controlled by the policies and the social reasons including declining fertility rate,it deviates from the current view of the youth towards marriage,resulting in many serious consequences such as young people’s rejection.In addition,this research found that male and female have great differences in their views on marriage,and men’s resistance to marriage is far greater than that of women,which is departure from the public’s cognition.The reasons behind this need to be explored in order to solve the marriage and love problems of young people in today’s era and realize the healthy development of young marriage.展开更多
Multilingual corpora have well been recognised as a valuable resource in contrastive and translation studies.This article investigates the development and use of multilingual corpora with a focus on work done in Scand...Multilingual corpora have well been recognised as a valuable resource in contrastive and translation studies.This article investigates the development and use of multilingual corpora with a focus on work done in Scandinavia with the purpose of showing how parallel corpora can be useful within different fields of language descriptions:lexis,grammar and discourse.It also presents a case study that demonstrates how a parallel corpus can be used in comparing two seemingly equivalent future-referring expressions cross-linguistically,namely the English 'be going to' and the Norwegian 'kommer til '('come to').展开更多
Relationship between insulin-like growth factor-l receptor (IGF-IR) and luteinizing hormone receptor (LHR) mRNA expression as well as their regulation was determined in rat corpora lutea (CL) . In the CL of estrous cy...Relationship between insulin-like growth factor-l receptor (IGF-IR) and luteinizing hormone receptor (LHR) mRNA expression as well as their regulation was determined in rat corpora lutea (CL) . In the CL of estrous cycle rat, LHR mRNA positive CL expressed high level of mRNA of IGF-IR. While the expression of LHR mRNA decreased on estrus, the CL still expressed relatively high level of IGF-IR mRNA. In pseudopregnant rat CL, the expression level of LHR mRNA was low on day 1, the most intense signals were detected on day 8, the signals of LHR mRNA became undetectable on day 14. In contrast to LHR expression, the high level of IGF-IR mRNA was observed in pseudopregnant CL of day 1, and thereafter its signals were detected from day 2 to day 14. Pregnant rat CL expressed both LHR and IGF-IR mRNAs. IGF-I stimulated LHR expression in CL. PGF2ainhibited expression of IGF-IR and LHR. PGE2 negated the inhibiting effects of PGF2α. These data suggest that IGF-I may be involved in regulating CL function, and展开更多
1 Introduction Lady beetle (Coccinella septempunctata) is an important natural enemy of aphids.Our data show that JH produced in the corpora allata (CA) in the adult beetle playsa key role in regulating its reproducti...1 Introduction Lady beetle (Coccinella septempunctata) is an important natural enemy of aphids.Our data show that JH produced in the corpora allata (CA) in the adult beetle playsa key role in regulating its reproduction. Recently, it is demonstrated that CA ininsects are target tissues of allatostatin and allatotropin. Juvenile hormone (JH) issynthesized and released by CA and plays a vital role in insect development, primarilyin the control of metamorphosis, sexual maturation and reproduction. The activity ofCA during reproduction could be modulated by stimulatory factors (Allatotropicfactor, ATF), inhibitory factors (Allatostatic factor AST) or both.展开更多
Arabic is the world’s first language,categorized by its rich and complicated grammatical formats.Furthermore,the Arabic morphology can be perplexing because nearly 10,000 roots and 900 patterns were the basis for ver...Arabic is the world’s first language,categorized by its rich and complicated grammatical formats.Furthermore,the Arabic morphology can be perplexing because nearly 10,000 roots and 900 patterns were the basis for verbs and nouns.The Arabic language consists of distinct variations utilized in a community and particular situations.Social media sites are a medium for expressing opinions and social phenomena like racism,hatred,offensive language,and all kinds of verbal violence.Such conduct does not impact particular nations,communities,or groups only,extending beyond such areas into people’s everyday lives.This study introduces an Improved Ant Lion Optimizer with Deep Learning Dirven Offensive and Hate Speech Detection(IALODL-OHSD)on Arabic Cross-Corpora.The presented IALODL-OHSD model mainly aims to detect and classify offensive/hate speech expressed on social media.In the IALODL-OHSD model,a threestage process is performed,namely pre-processing,word embedding,and classification.Primarily,data pre-processing is performed to transform the Arabic social media text into a useful format.In addition,the word2vec word embedding process is utilized to produce word embeddings.The attentionbased cascaded long short-term memory(ACLSTM)model is utilized for the classification process.Finally,the IALO algorithm is exploited as a hyperparameter optimizer to boost classifier results.To illustrate a brief result analysis of the IALODL-OHSD model,a detailed set of simulations were performed.The extensive comparison study portrayed the enhanced performance of the IALODL-OHSD model over other approaches.展开更多
将中医临床病历分为五大类问题,利用Transformers的双向编码器,在训练文本分类器之前,用未标注的临床语料库来微调ERNIE(Traditional Chinese Medicine-ERNIE)模型,精炼出一个针对中医知识领域的TCM-ERNIE模型,该语料库只使用临床记录...将中医临床病历分为五大类问题,利用Transformers的双向编码器,在训练文本分类器之前,用未标注的临床语料库来微调ERNIE(Traditional Chinese Medicine-ERNIE)模型,精炼出一个针对中医知识领域的TCM-ERNIE模型,该语料库只使用临床记录文本中的汉字作为输入,无须再进行预处理或特征提取.最后采用基准数据集来评估TCM-ERNIE模型和传统文本分类器,取得了89.39%±0.35%的分类精度,Macro F1为88.64%±0.40%,Micro F1为89.39%±0.35%,还采用可视化的方法来显示注意力权重,进一步揭示临床病历文本中的指标性症状.展开更多
Automatic Speech Emotion Recognition(SER)is used to recognize emotion from speech automatically.Speech Emotion recognition is working well in a laboratory environment but real-time emotion recognition has been influen...Automatic Speech Emotion Recognition(SER)is used to recognize emotion from speech automatically.Speech Emotion recognition is working well in a laboratory environment but real-time emotion recognition has been influenced by the variations in gender,age,the cultural and acoustical background of the speaker.The acoustical resemblance between emotional expressions further increases the complexity of recognition.Many recent research works are concentrated to address these effects individually.Instead of addressing every influencing attribute individually,we would like to design a system,which reduces the effect that arises on any factor.We propose a two-level Hierarchical classifier named Interpreter of responses(IR).Thefirst level of IR has been realized using Support Vector Machine(SVM)and Gaussian Mixer Model(GMM)classifiers.In the second level of IR,a discriminative SVM classifier has been trained and tested with meta information offirst-level classifiers along with the input acoustical feature vector which is used in primary classifiers.To train the system with a corpus of versatile nature,an integrated emotion corpus has been composed using emotion samples of 5 speech corpora,namely;EMO-DB,IITKGP-SESC,SAVEE Corpus,Spanish emotion corpus,CMU's Woogle corpus.The hierarchical classifier has been trained and tested using MFCC and Low-Level Descriptors(LLD).The empirical analysis shows that the proposed classifier outperforms the traditional classifiers.The proposed ensemble design is very generic and can be adapted even when the number and nature of features change.Thefirst-level classifiers GMM or SVM may be replaced with any other learning algorithm.展开更多
近年来,使用平行语料库进行汉译英研究已成为国内翻译学界的一大热点。本研究自建平行语料库,从词汇特征入手,对汉语学术著作《语言符号学》及其英译本,以及英语学术著作Handbook of Semiotics(以下简称Handbook)的词汇丰富度进行了比...近年来,使用平行语料库进行汉译英研究已成为国内翻译学界的一大热点。本研究自建平行语料库,从词汇特征入手,对汉语学术著作《语言符号学》及其英译本,以及英语学术著作Handbook of Semiotics(以下简称Handbook)的词汇丰富度进行了比较研究。研究结果表明:1)《语言符号学》英译本的词汇多样性与Handbook比较接近,未呈现出词汇范围窄化的倾向;2)相对于原作,《语言符号学》英译本的词汇密度有所降低,连词、介词和代词存在扩增现象;3)《语言符号学》英译本的词汇复杂度低于Handbook,前者的阅读难度相对较低。展开更多
文摘The main goal of English teaching in colleges and universities is to cultivate students’ability to use the language,but many students are still unable to complete oral communication fluently after years of study.For this reason,teachers need to deeply analyze and study the linguistic features of oral English corpora and formulate reasonable teaching strategies to improve students’oral expression skills.This paper outlines the linguistic features of oral English corpora,comparatively analyzes the differences between oral English corpora and written English corpora,and explores effective teaching strategies,hoping to provide guidelines for relevant teachers.
文摘The present article provides a critical review of Randi Reppen's impressing book Using Corpora in the Language Classroom.It's argued that Randi Reppen's book,despite a few slight flaws,has a strong practical orientation and is a laudable effort to make English language teachers to realize the importance and practicality of bringing corpora into classroom in digital age.The book is particularly worthy of reading for those language teachers(especially beginner teachers) who want to breathe new life into their English teaching.
文摘This paper examines the application of electronic corpora to English classroom of lexical learning.It starts with a literature review of basic issues on corpus linguistics and theories underlying lexical study,followed by discussion on the specific lexical learning aspects in which a corpus might provide some insight.Based other research like data-driven learning(DDL)in this area,the paper goes further by exploring the possibility and ways of applying corpora in vocabulary learning classroom.
基金This research is supported by Shifa International Hospital,Pakistan.Endocrine patients’data contributed for diagnosis of diabetes,and its comorbidities holds a lot of worth to come up with these observations from experimental study。
文摘The motivation for this research comes from the gap found in discovering the common ground for medical context learning through analytics for different purposes of diagnosing,recommending,prescribing,or treating patients for uniform phenotype features from patients’profile.The authors of this paper while searching for possible solutions for medical context learning found that unified corpora tagged with medical nomenclature was missing to train the analytics for medical context learning.Therefore,here we demonstrated a mechanism to come up with uniform NER(Named Entity Recognition)tagged medical corpora that is fed with 14407 endocrine patients’data set in Comma Separated Values(CSV)format diagnosed with diabetes mellitus and comorbidity diseases.The other corpus is of ICD-10-CM coding scheme in text format taken from www.icd10data.com.ICD-10-CM corpus is to be tagged for understanding the medical context with uniformity for which we are conducting different experiments using common natural language programming(NLP)techniques and frameworks like TensorFlow,Keras,Long Short-Term Memory(LSTM),and Bi-LSTM.In our preliminary experiments,albeit label sets in form of(instance,label)pair were tagged with Sequential()model formed on TensorFlow.Keras and Bi-LSTM NLP algorithms.The maximum accuracy achieved for model validation was 0.8846.
基金The authors wish to thank Prof.Emeritus Reinhold J.Hutz,PhD of the Department of Biological Sciences,University of Wisconsin-Milwaukee,USA,for his editing and helpful adviceThis work was supported by the National Natural Science Foundation of China(31501956 and 31572403).
文摘In the present study,we aimed to investigate a protective role for resveratrol against the effects of immobilization stress on corpora lutea(CL)of mice in early pregnancy.A total of 45 early-pregnant mice were divided into no immobilization stress(NIS)group,immobilization stress(IS)group,and immobilization and resveratrol treatment(IS+RES)group(n=15).Mice were immobilized in plastic tubes(50 mL)for 3 h per day during day 1 to 7 of pregnancy.In the IS+RES group,5 mg kg-'d-1 of resveratrol was administered just prior to application of stress.We analyzed apoptotic activity in CL by Western botting analysis(WB),transmission electron microscopy(TEM),and immunohistochemistry(IHC).Serum progesterone levels were examined with radioimmunoassay(RIA).IHC results showed that the intensity of positive staining for Bax was increased,and for BcI-2 was decreased in CL after IS,while resveratrol treatment reversed the positive staining for Bax and Bcl-2.WB revealed that immobilization stress up-regulated the expression of Bax and caspase-9,and down-regulated Bcl-2 expression,while resveratrol treatment attenuated the effects of immobilization stress on the expression of Bax,Bcl-2 and caspase-9.According to our TEM results,apoptosis as defined by chromatin condensation was found in CL after immobilization stress,while resveratrol inhibited the apoptosis.We also demonstrated that immobilization stress decreased progesterone concentrations and ovarian expression of StAR,while resveratrol restored the concentrations of progesterone and expression of StAR back to normal.These results indicated that immobilization stress induced luteal regression while resveratrol inhibited luteal regression,suggesting that resveratrol plays a protective role on corpora lutea of mice during early pregnancy.
文摘Digitalization has changed the way of information processing, and newtechniques of legal data processing are evolving. Text mining helps to analyze andsearch different court cases available in the form of digital text documents toextract case reasoning and related data. This sort of case processing helps professionals and researchers to refer the previous case with more accuracy in reducedtime. The rapid development of judicial ontologies seems to deliver interestingproblem solving to legal knowledge formalization. Mining context informationthrough ontologies from corpora is a challenging and interesting field. Thisresearch paper presents a three tier contextual text mining framework throughontologies for judicial corpora. This framework comprises on the judicial corpus,text mining processing resources and ontologies for mining contextual text fromcorpora to make text and data mining more reliable and fast. A top-down ontologyconstruction approach has been adopted in this paper. The judicial corpus hasbeen selected with a sufficient dataset to process and evaluate the results.The experimental results and evaluations show significant improvements incomparison with the available techniques.
基金the Natural Science Foundation of Shandong Province, No. Y2004C04
文摘BACKGROUND: Insulin-like growth factor-I(IGF-1), as one of the important members of growth factor family, participants in the regulation of many physiological functions and behaviors, having very strong neuroprotective effect. However, the expression of IGF-1 following cerebral ischemia/reperfusion is still disputed. OBJECTIVE: To observe the expression of IGF-1 and protein of corpora striata in ischemic side at the early stage of middle cerebral artery ischemia/reperfusion in rhesus monkey. DESIGN: A completely randomized grouping design, controlled animal experiment. SETTING: Institute of Cerebrovascular Disease, Affiliated Hospital of Medical College of Qingdao University. MATERIALS: ① Totally 17 rhesus monkeys , of either gender, aged 4 to 5 years, were enrolled . Seven rhesus monkeys observed with gene chip were randomly divided into 2 groups: sham operation group (n=3) and ischemia/reperfusion group (n=4). Ten rhesus monkeys observed with in situ hybridization and immunohistochemistry method were randomly divided into 2 groups: sham operation group (n=3)and ischemia/reperfusion group (n=7). Rhesus monkeys observed under microscope were divided into 2 groups: sham operation group (n=6) and ischamia/reperfusion group (n=11). ② Materials used in the experiment: cresyl violet (Sigma Company, America); immunohistochemical reagent kit ( Huamei Bio-engineering Company); In situ hybridization reagent kit (Boshide Bio-engineering Co.Ltd, Wuhan); 12 800 dots chip (Boxing Company, Shanghai). METHODS: This experiment was carried out at the Institute of Cerebrovascular Disease, Affiliated Hospital of Medical College of Qingdao University from January 2001 to December 2003. ① The onset area of middle cerebral artery was blocked for 2 hours, middle cerebral artery ischemia/reperfusion models were created. ② After ischemia/reperfusion for 24 hours, cerebral tissue sections of rhesus monkeys were prepared and stained with cresyl violet. Image analysis was performed with 500IW image analysis software. Morphological change of corpora striata of operative side was observed in the rhesus monkeys between two groups. Total RNA was extracted from cerebral tissue. ③ Detection of gene chip: Cy3-duTP and Cy5-duTP were used to respectively perform reverse transcription labeling. The sample was reversely transcribed into cDNA, then hybridized with cDNA of cerebral tissue. Genes with the separate absolute value of cy3 and cy5>800, cy3/cy5 > 2(high expression) or < 0.5 (low expression) were found out. Those were genes with differential expression. ④ The expressions of IGF-1 mRNA and protein level of corpora striata in ischemic side of rhesus monkeys were detected between sham operation group and ischemia/reperfusion group at 9 and 24 hours after ischemia/reperfusion with in situ hybridization method and immunohistochemical method. Brown granules were IGF-1 protein positive cells. ⑤ Analysis of variance was used in the difference comparison of measurement data among groups. MAIN OUTCOME MEASURES: ① Change of morphological structure of corpora striata at ischemic side in rhesus monkeys. ② Change of cerebral gene expression profiles at ischemia/reperfusion in rhesus monkeys between two groups. ③ Expression of IGF-1 mRNA and protein level of corpora striata at ischemia/reperfusion in rhesus monkeys between two groups. RESULTS: ① Pathological change : Obvious pathological change of cerebral infarction appeared in the ischemia and reperfusion group, while there was no such pathological change in the sham operation group. ② Change of gene expression profile : There were 4480 genes with difference expression in the ischemia/reperfusion group and sham-operation group, in which, 260 genes had high expression and their absolute value was over 800, and 63 genes had low expression. cy3/cy5 of IGF-1 was 0.379, being relative low expression. ③ IGF-1 mRNA and protein positive cell counts in corpora striata at cerebral ischemic side[IGF-1 mRNA:(9.72±1.18),(9.11±0.76),(14.77±0.60) counts/field;IGF-1 protein:(15.11±1.83),(15.39±0.78),(34.62±0.97)counts/field,P < 0.05-0.01]. CONCLUSION: IGF-1 mRNA and protein are lowly expressed in middle cerebral artery of rhesus monkeys at ischemia/reperfusion.
文摘A novel visualized sound description, called sound dendrogram is proposed to make manual annotation easier when building large speech corpora. It is a lattice structure built from a group of “seed regions” and through an iterative procedure of mergence. A simple but reliable extraction method of “seed regions” and advanced distance metric are adopted to construct the sound dendrogram, so that it can present speech’s structure character ranging from coarse to fine in a visualized way. Tests show that all phonemic boundaries are contained in the lattice structure of sound dendrogram and very easy to identify. Sound dendrogram can be a powerful assistant tool during the process of speech corpora’s manual annotation.
文摘The rising of aging and the declining of birth rates have forced the public to focus on the youth’s view on marriage.Based on critical discourse analysis and combined with Fairclough’s three-dimensional discourse analysis model,this paper builds a“Chinese media News Report Corpus on the topic of‘marriage’”whose news are collected from China Daily.It is found that the discourses are neutral and objective with regard to the advantages and disadvantages of marriage,but in general,it is still a traditional view of marriage that is inevitable and closely related to fertility.Although this is controlled by the policies and the social reasons including declining fertility rate,it deviates from the current view of the youth towards marriage,resulting in many serious consequences such as young people’s rejection.In addition,this research found that male and female have great differences in their views on marriage,and men’s resistance to marriage is far greater than that of women,which is departure from the public’s cognition.The reasons behind this need to be explored in order to solve the marriage and love problems of young people in today’s era and realize the healthy development of young marriage.
文摘Multilingual corpora have well been recognised as a valuable resource in contrastive and translation studies.This article investigates the development and use of multilingual corpora with a focus on work done in Scandinavia with the purpose of showing how parallel corpora can be useful within different fields of language descriptions:lexis,grammar and discourse.It also presents a case study that demonstrates how a parallel corpus can be used in comparing two seemingly equivalent future-referring expressions cross-linguistically,namely the English 'be going to' and the Norwegian 'kommer til '('come to').
文摘Relationship between insulin-like growth factor-l receptor (IGF-IR) and luteinizing hormone receptor (LHR) mRNA expression as well as their regulation was determined in rat corpora lutea (CL) . In the CL of estrous cycle rat, LHR mRNA positive CL expressed high level of mRNA of IGF-IR. While the expression of LHR mRNA decreased on estrus, the CL still expressed relatively high level of IGF-IR mRNA. In pseudopregnant rat CL, the expression level of LHR mRNA was low on day 1, the most intense signals were detected on day 8, the signals of LHR mRNA became undetectable on day 14. In contrast to LHR expression, the high level of IGF-IR mRNA was observed in pseudopregnant CL of day 1, and thereafter its signals were detected from day 2 to day 14. Pregnant rat CL expressed both LHR and IGF-IR mRNAs. IGF-I stimulated LHR expression in CL. PGF2ainhibited expression of IGF-IR and LHR. PGE2 negated the inhibiting effects of PGF2α. These data suggest that IGF-I may be involved in regulating CL function, and
基金Project supported by the National Natural Science Foundation of China.
文摘1 Introduction Lady beetle (Coccinella septempunctata) is an important natural enemy of aphids.Our data show that JH produced in the corpora allata (CA) in the adult beetle playsa key role in regulating its reproduction. Recently, it is demonstrated that CA ininsects are target tissues of allatostatin and allatotropin. Juvenile hormone (JH) issynthesized and released by CA and plays a vital role in insect development, primarilyin the control of metamorphosis, sexual maturation and reproduction. The activity ofCA during reproduction could be modulated by stimulatory factors (Allatotropicfactor, ATF), inhibitory factors (Allatostatic factor AST) or both.
基金This work was supported by the National Natural Science Foundation of China （Grant Nos. 61133012, 61273321） and the National 863 Leading Technology Research Project （2012AA011102）. Special thanks to Wanxiang Che, Yanyan Zhao, Wei He, Fikadu Gemechu, Yuhang Guo, Zhenghua Li, Meishan Zhang and the anonymous reviewers for insightful comments and suggestions.
基金Princess Nourah bint Abdulrahman University Researchers Supporting Project number(PNURSP2022R263)Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia.The authors would like to thank the Deanship of Scientific Research at Umm Al-Qura University for supporting this work by Grant Code:22UQU4340237DSR43.
文摘Arabic is the world’s first language,categorized by its rich and complicated grammatical formats.Furthermore,the Arabic morphology can be perplexing because nearly 10,000 roots and 900 patterns were the basis for verbs and nouns.The Arabic language consists of distinct variations utilized in a community and particular situations.Social media sites are a medium for expressing opinions and social phenomena like racism,hatred,offensive language,and all kinds of verbal violence.Such conduct does not impact particular nations,communities,or groups only,extending beyond such areas into people’s everyday lives.This study introduces an Improved Ant Lion Optimizer with Deep Learning Dirven Offensive and Hate Speech Detection(IALODL-OHSD)on Arabic Cross-Corpora.The presented IALODL-OHSD model mainly aims to detect and classify offensive/hate speech expressed on social media.In the IALODL-OHSD model,a threestage process is performed,namely pre-processing,word embedding,and classification.Primarily,data pre-processing is performed to transform the Arabic social media text into a useful format.In addition,the word2vec word embedding process is utilized to produce word embeddings.The attentionbased cascaded long short-term memory(ACLSTM)model is utilized for the classification process.Finally,the IALO algorithm is exploited as a hyperparameter optimizer to boost classifier results.To illustrate a brief result analysis of the IALODL-OHSD model,a detailed set of simulations were performed.The extensive comparison study portrayed the enhanced performance of the IALODL-OHSD model over other approaches.
文摘将中医临床病历分为五大类问题,利用Transformers的双向编码器,在训练文本分类器之前,用未标注的临床语料库来微调ERNIE(Traditional Chinese Medicine-ERNIE)模型,精炼出一个针对中医知识领域的TCM-ERNIE模型,该语料库只使用临床记录文本中的汉字作为输入,无须再进行预处理或特征提取.最后采用基准数据集来评估TCM-ERNIE模型和传统文本分类器,取得了89.39%±0.35%的分类精度,Macro F1为88.64%±0.40%,Micro F1为89.39%±0.35%,还采用可视化的方法来显示注意力权重,进一步揭示临床病历文本中的指标性症状.
文摘Automatic Speech Emotion Recognition(SER)is used to recognize emotion from speech automatically.Speech Emotion recognition is working well in a laboratory environment but real-time emotion recognition has been influenced by the variations in gender,age,the cultural and acoustical background of the speaker.The acoustical resemblance between emotional expressions further increases the complexity of recognition.Many recent research works are concentrated to address these effects individually.Instead of addressing every influencing attribute individually,we would like to design a system,which reduces the effect that arises on any factor.We propose a two-level Hierarchical classifier named Interpreter of responses(IR).Thefirst level of IR has been realized using Support Vector Machine(SVM)and Gaussian Mixer Model(GMM)classifiers.In the second level of IR,a discriminative SVM classifier has been trained and tested with meta information offirst-level classifiers along with the input acoustical feature vector which is used in primary classifiers.To train the system with a corpus of versatile nature,an integrated emotion corpus has been composed using emotion samples of 5 speech corpora,namely;EMO-DB,IITKGP-SESC,SAVEE Corpus,Spanish emotion corpus,CMU's Woogle corpus.The hierarchical classifier has been trained and tested using MFCC and Low-Level Descriptors(LLD).The empirical analysis shows that the proposed classifier outperforms the traditional classifiers.The proposed ensemble design is very generic and can be adapted even when the number and nature of features change.Thefirst-level classifiers GMM or SVM may be replaced with any other learning algorithm.
文摘近年来,使用平行语料库进行汉译英研究已成为国内翻译学界的一大热点。本研究自建平行语料库,从词汇特征入手,对汉语学术著作《语言符号学》及其英译本,以及英语学术著作Handbook of Semiotics(以下简称Handbook)的词汇丰富度进行了比较研究。研究结果表明:1)《语言符号学》英译本的词汇多样性与Handbook比较接近,未呈现出词汇范围窄化的倾向;2)相对于原作,《语言符号学》英译本的词汇密度有所降低,连词、介词和代词存在扩增现象;3)《语言符号学》英译本的词汇复杂度低于Handbook,前者的阅读难度相对较低。
