Analyze the compatibility between cosmetics and live streaming e-commerce from its own nature,marketing means and supply chain characteristics.According to the prominent problems,sort out the relationship between all ...Analyze the compatibility between cosmetics and live streaming e-commerce from its own nature,marketing means and supply chain characteristics.According to the prominent problems,sort out the relationship between all parties in the cosmetics live e-commerce industry chain.Combined with the latest regulatory policies of live streaming e-commerce and cosmetics,the responsibilities of different subjects in cosmetics live streaming e-commerce are summarized,and relevant suggestions and countermeasures are put forward for the standardization and development of live streaming e-commerce.Cosmetics brand owners are the first responsible persons for product quality.Anchors,as a mixed identity between intermediary,advertising spokesperson and operator,should bear stricter joint and several liability when recommending products related to consumers’health.If anchors fail to clearly identify themselves in the recommendation process,thus causing consumers to mistake them for the operator of the cosmetics,they should assume the obligations of the operator.展开更多
Borneol, as a traditional natural permeation enhancer, has been widely used to promote the transdermal absorption of active ingredients. In this review, the mechanism of borneol in promoting permeation by destroying t...Borneol, as a traditional natural permeation enhancer, has been widely used to promote the transdermal absorption of active ingredients. In this review, the mechanism of borneol in promoting permeation by destroying the highly ordered lipid structure of the lipid layer and by destroying the hydrogen-bond network was described. The application of borneol in promoting the transdermal absorption of the active ingredients of traditional Chinese medicine and chemical drugs was introduced. The application of borneol as a natural ingredient added to functional cosmetics was summarized, and its effects on skin-spot treatment, acne skin care, eczema skin care, skin repair and anti-oxidation were introduced. Finally, the possible problems in the application of borneol in cosmetics were put forward, and the application prospect of borneol in the development of cosmetics was given.展开更多
To study the efficacy of lip moisturizing cosmetics and explore the methods for evaluating their efficacy.The claimed efficacy and number of claimed efficacy of 44 lip moisturizing cosmetics were investigated,and a co...To study the efficacy of lip moisturizing cosmetics and explore the methods for evaluating their efficacy.The claimed efficacy and number of claimed efficacy of 44 lip moisturizing cosmetics were investigated,and a combination of in vitro and human testing was used to evaluate the efficacy of the lip moisturizing cosmetics.The efficacy claims of lip cosmetics mainly included 4 categories of moisturizing,repairing,soothing and anti-wrinkle,with 79.55%of the products claiming 3~4 categories of efficacy.In the in vitro test,the cell morphology of the skin damage model improved and the secretion of pro-inflammatory factors decreased significantly.In the human trial,the water content,skin softness and brightness L value of the cuticle of the lips increased significantly in 31 subjects,and the transepidermal water loss,redness a value,and the area and volume of lip wrinkles decreased significantly;the dryness of the lip skin and the uniformity of the skin texture improved significantly.The dryness of lip skin and the uniformity of skin texture were significantly improved.The results show that the moisture content of the stratum corneum can be used to evaluate the moisturizing efficacy of lip products.The transepidermal water loss,skin color,skin softness and expert assessment can be used to evaluate the repairing efficacy.The observation of cell morphology of skin damage models and the detection of pro-inflammatory factor content can be used to evaluate the soothing efficacy.The area and volume of lip wrinkles can be used to evaluate the anti-wrinkle efficacy of products.展开更多
This article described the current regulatory requirements of cosmetics in the United States,listed the major changes and adjustments of the Modernization of Cosmetics Regulation Act of 2022,such as the mandatory syst...This article described the current regulatory requirements of cosmetics in the United States,listed the major changes and adjustments of the Modernization of Cosmetics Regulation Act of 2022,such as the mandatory system of adverse event reporting and the registration of voluntary changes to mandatory,and analyzed the new regulatory requirements in depth,and put forward some suggestions for enterprises to cope with the strategy,so as to help enterprises adapt to the new policy more smoothly when exporting cosmetics.展开更多
Recent studies have found that nicotinamide mononucleotide(nicotinamide mononucleotide,NMN)also has certain anti-aging,photoprotection,anti-oxidation,and soothing to the skin,while affects the level of nicotinamide ad...Recent studies have found that nicotinamide mononucleotide(nicotinamide mononucleotide,NMN)also has certain anti-aging,photoprotection,anti-oxidation,and soothing to the skin,while affects the level of nicotinamide adenine dinucleotide(nicotinamide adenine dinucleotide,NAD+)to improve aging-related diseases.These skincare features have laid the foundation for its application in cosmetics.NMN has been used in cosmetics and sold on the market in foreign countries,but there have been debates about its safety.It is currently as a new raw material for cosmetics in China,and its safety is also under monitoring.This paper systematically reviewed the basic properties,skin care functions and the safety of its application in cosmetics,aiming to provide theoretical reference for the development and application of NMN.展开更多
In order to search an appropriate evaluation method for the soothing effect of cosmetics,the LPS-induced macrophage model,SDS-stimulated zebrafish embryos model and the clinical assessment were used.The results showed...In order to search an appropriate evaluation method for the soothing effect of cosmetics,the LPS-induced macrophage model,SDS-stimulated zebrafish embryos model and the clinical assessment were used.The results showed that the concentration of NO and IL-6 was significantly reduced in LPS-induced RAW264.7 cells when applied to two essences.The inhibition rate of NO-release was 85.87%and 84.57%,while IL-6 was 44.18%and 38.76%,respectively.Furthermore,the spontaneous rotating of zebrafish embryos was significantly decreased to 51.85%and 76.54%in SDS-stimulated zebrafish embryos model.In the 28 days of clinical assessment,the concentration of hydration was significantly increased to 55.56%and 39.61%,while the erythrodesis was significantly decreased to 4.75%and 6.68%.This indicates that the three evaluation methods of soothing efficacy in this research were effective,and can be used in the evaluation of cosmetics.展开更多
Borneol,as a traditional natural permeation enhancer,has been widely used to promote the transdermal absorption of active ingredients.The mechanism of borneol in promoting permeation by destroying the highly ordered l...Borneol,as a traditional natural permeation enhancer,has been widely used to promote the transdermal absorption of active ingredients.The mechanism of borneol in promoting permeation by destroying the highly ordered lipid structure of the lipid layer and by destroying the hydrogen-bond network was described.The application of borneol in promoting the transdermal absorption of the active ingredients of traditional Chinese medicine and chemical drugs was introduced.The application of borneol as a natural ingredient added to functional cosmetics was summarized,and its effects on skin-spot treatment,acne skin care,eczema skin care,skin repair and anti-oxidation were introduced.Finally,the possible problems in the application of borneol in cosmetics were put forward,and the application prospect of borneol in the development of cosmetics was given。展开更多
An ultrahigh performance liquid chromatography-triple quadrupole tandem mass spectrometry(UPLC-MS/MS)was established to quickly and accurately determine the content of oleuropein in cosmetics.The samples were extracte...An ultrahigh performance liquid chromatography-triple quadrupole tandem mass spectrometry(UPLC-MS/MS)was established to quickly and accurately determine the content of oleuropein in cosmetics.The samples were extracted with methanol-aqueous solution,and the mobile phase with methanol-formic acid solution(0.1 mol/L)=40∶60 was separated by Agilent ZORBAX Eclipse Plus C18(2.1 mm×50 mm×1.8μm-Micron)column temperature 30℃,flow rate 0.3 mL/min.The MS end was detected by electrospray negative mode ionization(ESI-)and multiple reaction monitoring(MRM)mode.The results show a good linear relationship in the range of 0.002~5 mg/L,with a correlation coefficient R2 of 0.999,5.Method recovery range from 84.2%~107.6%and the relative standard deviation RSD is 5.8%.The detection time is 5 min,the detection limit is 0.000,6 mg/L,and the limit of quantification is 0.002 mg/L.This method has the advantages of convenient operation,low quantification limit,high precision and good repeatability,and is suitable for measuring the content of oleuropein in many kinds of cosmetics.展开更多
On April 7th,2023,the supervisory department of Xuhui district published the first Guidance to“Cosmetics Samples”for the First Time(Trial).It unified the management requirement regarding cosmetics samples,guided man...On April 7th,2023,the supervisory department of Xuhui district published the first Guidance to“Cosmetics Samples”for the First Time(Trial).It unified the management requirement regarding cosmetics samples,guided managers to develop responsibility awareness and prevent and advert risks beforehand.Besides,it identified the definition of“cosmetics samples”.展开更多
Cosmetic companies are trying to include more sustainability in their strategies. But, showing commitment is always a challenge for them. This work consists in showing the degree of commitment of cosmetic companies in...Cosmetic companies are trying to include more sustainability in their strategies. But, showing commitment is always a challenge for them. This work consists in showing the degree of commitment of cosmetic companies in their marketing practices. The qualitative study carried out aims to determine the level of their commitment in terms of sustainability, based on 10 websites of “sustainable” cosmetics companies that sell their products online, and on defining sustainability criteria for each variable of the marketing mix. The results indicate that the majority of the companies analyzed are aware of the importance of sustainability and have taken measures to have a positive impact on the economy, society and the environment. The companies have made considerable efforts in “product” and “communication” strategies, but additional improvements can be envisaged for “price” and “distribution” strategies.展开更多
On April 10,2023,the Shanghai Municipal Medical Products Administration issued a notice on the public consultation of the“Shanghai Pudong New Area General Cosmetics On-site Personalized Service Review Rules(for trial...On April 10,2023,the Shanghai Municipal Medical Products Administration issued a notice on the public consultation of the“Shanghai Pudong New Area General Cosmetics On-site Personalized Service Review Rules(for trial implementation)”(draft for comment),marking the public call for comments from April 3 to May 2,2023.展开更多
With the advancement of economic globalization,the flow of commodities from one country to another has become closer and closer.Especially in recent years,the logistics industry has been developing rapidly,overseas pu...With the advancement of economic globalization,the flow of commodities from one country to another has become closer and closer.Especially in recent years,the logistics industry has been developing rapidly,overseas purchasing agents and cross-border online shopping have been enormously prevailing,and accordingly more and more British and American cosmetics expect to occupy a place in the huge market of China.Therefore,it is particularly important to explore the Chinese translation strategies for British and American cosmetic brands.Based on the theory of reception aesthetics,this thesis takes the corpus Estee Lauder,La mer,and other famous cosmetics brands.The thesis proposes several methods for translating cosmetic brands:transliteration for proper names like person or geography names;free translation to recreate brand aesthetics;creative translation for new brands;and adapted translation for divergence in language habits.Therefore,this thesis is of theoretical and practical significance as far as the field of cosmetics is concerned.展开更多
To evaluate and discuss two novels in vitro alternative tests which based on the 2nd and 4th event of the AOP in skin sensitization and their application in skin sensitization evaluation of cosmetics in vitro.The DSen...To evaluate and discuss two novels in vitro alternative tests which based on the 2nd and 4th event of the AOP in skin sensitization and their application in skin sensitization evaluation of cosmetics in vitro.The DSens(DSens method)and Jurkat(TCPA method)were used as the test models and 9 of reference chemicals and 12 kinds of cosmetic products were used to confirm and assess the application capability in skin sensitization.The results showed that the DSens method was more sensitive to the reference chemicals compare to the TCPA method.All the results of cosmetic products showed a high consistency between these two assays and h-CLAT or in vivo assay.As the new screening method for skin sensitization evaluation of cosmetics,the in vitro alternative tests based on AOP have certain effectiveness.The reasonable combination strategy can bring a bright future for the development and application of animal alternative test in China.展开更多
This article is based on data analysis from 2012 to 2019 of imported non-special-use cosmetics registration quantity,special-use cosmetics registration quantity,children's cosmetics registration quantity,etc.And a...This article is based on data analysis from 2012 to 2019 of imported non-special-use cosmetics registration quantity,special-use cosmetics registration quantity,children's cosmetics registration quantity,etc.And also based on the Regulation on Supervision and Administration of Cosmetics(Draft),and so on.This article will briefly discuss the influence of the new trend of Chinese cosmetics regulations on the development of the cosmetics industry.According to data analysis,the pre-market approval process for cosmetics is closely related to the annual increase in the new product registrations quantity.Since March 1st,2017,the reform of the imported non-special-use cosmetics registration was first initiated in Pudong New Area in Shanghai,the imported cosmetics registration quantity has increased significantly,so as the non-special-use children’s registration.Under the background of no obvious change in the pre-marketing approval process of imported special-use cosmetics,there is no significant increase in the quantity of annual registration.Among the nine categories of special-use cosmetics,sunscreen and whitening cosmetics accounted for the highest proportion,followed by hair dyeing.For the hair-growing,breast beauty,fitness categories of special-use cosmetics,the registration quantity each year was very low due to the low approval rate,long approval process and high testing costs,etc.According to the new trend of Chinese cosmetics regulations,the idea of cosmetics supervision and administration is changing from focusing on pre-market approval procedures to focusing on post-market surveillance.展开更多
An effective and environmentally friendly method based on ionic liquid-based ultrasound-assisted emulsification microextraction(IL-USAEME) and high performance liquid chromatography (HPLC) has been developed for the d...An effective and environmentally friendly method based on ionic liquid-based ultrasound-assisted emulsification microextraction(IL-USAEME) and high performance liquid chromatography (HPLC) has been developed for the determination of nine hormones including three glucocorticoids, one androgen and five progestogens in cosmetics. Several factors that affect the extraction efficiency, such as the kinds and volume of ionic liquid, salt concentration, ultrasonic power and time, and centrifugation time were investigated and optimized. Under the optimum extraction condition, the recoveries of analytes ranged from 85.97% to 108.84% except prednisolone (62.30%). The intraday and interday precision was below 2.51% and 3.30%, respectively.展开更多
As nanotechnology finds new applications, the formulation and use of nano-particulate structures in the production of cosmetics and cosmeceuticals keeps increasing. Nano-sized materials such as cubosomes, nanodots, li...As nanotechnology finds new applications, the formulation and use of nano-particulate structures in the production of cosmetics and cosmeceuticals keeps increasing. Nano-sized materials such as cubosomes, nanodots, liposomes, dendrimers, nano-emulsions are now becoming regular ingredients in the cosmetic space. These nanoparticle-based cosmetics or nano-cosmeceuticals have extended the boundaries of the applications of cosmetics in managing conditions of wrinkling, dehydrated and inelastic skin associated with aging and dispersed hyperpigmentation. With so many claims by giant cosmetic manufacturers on the several possibilities achievable by such products containing these, there remain valid questions needing answers. Such includes: what are the actual facts as opposed to unfounded expectations on use of nano-materials in cosmetics? What are the peculiar properties of Nano-sized structures? Any potential or actual health risks associated with nanoparticle-incorporated cosmetic products? What roles are the regulating authorities and academic researchers playing in the light of all these developments? This review attempts to answer these questions, taking a look at the updates on nano-sized materials used in cosmetics, while presenting actual advances made in nano-cosmetics amidst the seemingly not too obvious hidden risks.展开更多
The hexagonal boron nitride has been well investigated. Its layered structure is similar to that of graphite. In the manufacture of cosmetics, this structure is intended to improve the appearance, sensory aspect and m...The hexagonal boron nitride has been well investigated. Its layered structure is similar to that of graphite. In the manufacture of cosmetics, this structure is intended to improve the appearance, sensory aspect and makes it easy to mix excipients contained in the formulation in the mixture process. In cosmetology, the efficiency and the penetration of active substances into skin are known to be directly related to the particle size. However, only recently their nanostructured properties have been explored. In this work, the synthesis of hexagonal boron nitride in the nanoscale, its composition, structure, morphology and potential for future application in sunscreens are being investigated. The boron nitride was synthesized from boric acid and melamine to a heat treatment at 1600℃. The crystal structure was characterized by (XRD) and its morphology was examined by (SEM) and (TEM);the chemical composition was studied by (FTIR), (EDS) and (EELS), the texture characterization by (BET) and its potential in sunscreens by (FTIR and UV/VIS). Results have shown that boron nitride may be synthesized in the nanoscale and that this material has the potential to be incorporated into cosmetics.展开更多
The performance and formation mechanism of sensitive skin were summarized. Various evaluation methods for soothing skin cosmetics such as physical and chemical methods, biochemical methods, cell biological methods, th...The performance and formation mechanism of sensitive skin were summarized. Various evaluation methods for soothing skin cosmetics such as physical and chemical methods, biochemical methods, cell biological methods, three-dimensional recombinant skin model alternative method, animal experiment method, subjective evaluation, semi subjective evaluation and objective instrument evaluation method were introduced. The new idea of soothing efficacy evaluation was proposed and the development direction was put forward.展开更多
文摘Analyze the compatibility between cosmetics and live streaming e-commerce from its own nature,marketing means and supply chain characteristics.According to the prominent problems,sort out the relationship between all parties in the cosmetics live e-commerce industry chain.Combined with the latest regulatory policies of live streaming e-commerce and cosmetics,the responsibilities of different subjects in cosmetics live streaming e-commerce are summarized,and relevant suggestions and countermeasures are put forward for the standardization and development of live streaming e-commerce.Cosmetics brand owners are the first responsible persons for product quality.Anchors,as a mixed identity between intermediary,advertising spokesperson and operator,should bear stricter joint and several liability when recommending products related to consumers’health.If anchors fail to clearly identify themselves in the recommendation process,thus causing consumers to mistake them for the operator of the cosmetics,they should assume the obligations of the operator.
文摘Borneol, as a traditional natural permeation enhancer, has been widely used to promote the transdermal absorption of active ingredients. In this review, the mechanism of borneol in promoting permeation by destroying the highly ordered lipid structure of the lipid layer and by destroying the hydrogen-bond network was described. The application of borneol in promoting the transdermal absorption of the active ingredients of traditional Chinese medicine and chemical drugs was introduced. The application of borneol as a natural ingredient added to functional cosmetics was summarized, and its effects on skin-spot treatment, acne skin care, eczema skin care, skin repair and anti-oxidation were introduced. Finally, the possible problems in the application of borneol in cosmetics were put forward, and the application prospect of borneol in the development of cosmetics was given.
文摘To study the efficacy of lip moisturizing cosmetics and explore the methods for evaluating their efficacy.The claimed efficacy and number of claimed efficacy of 44 lip moisturizing cosmetics were investigated,and a combination of in vitro and human testing was used to evaluate the efficacy of the lip moisturizing cosmetics.The efficacy claims of lip cosmetics mainly included 4 categories of moisturizing,repairing,soothing and anti-wrinkle,with 79.55%of the products claiming 3~4 categories of efficacy.In the in vitro test,the cell morphology of the skin damage model improved and the secretion of pro-inflammatory factors decreased significantly.In the human trial,the water content,skin softness and brightness L value of the cuticle of the lips increased significantly in 31 subjects,and the transepidermal water loss,redness a value,and the area and volume of lip wrinkles decreased significantly;the dryness of the lip skin and the uniformity of the skin texture improved significantly.The dryness of lip skin and the uniformity of skin texture were significantly improved.The results show that the moisture content of the stratum corneum can be used to evaluate the moisturizing efficacy of lip products.The transepidermal water loss,skin color,skin softness and expert assessment can be used to evaluate the repairing efficacy.The observation of cell morphology of skin damage models and the detection of pro-inflammatory factor content can be used to evaluate the soothing efficacy.The area and volume of lip wrinkles can be used to evaluate the anti-wrinkle efficacy of products.
文摘This article described the current regulatory requirements of cosmetics in the United States,listed the major changes and adjustments of the Modernization of Cosmetics Regulation Act of 2022,such as the mandatory system of adverse event reporting and the registration of voluntary changes to mandatory,and analyzed the new regulatory requirements in depth,and put forward some suggestions for enterprises to cope with the strategy,so as to help enterprises adapt to the new policy more smoothly when exporting cosmetics.
文摘Recent studies have found that nicotinamide mononucleotide(nicotinamide mononucleotide,NMN)also has certain anti-aging,photoprotection,anti-oxidation,and soothing to the skin,while affects the level of nicotinamide adenine dinucleotide(nicotinamide adenine dinucleotide,NAD+)to improve aging-related diseases.These skincare features have laid the foundation for its application in cosmetics.NMN has been used in cosmetics and sold on the market in foreign countries,but there have been debates about its safety.It is currently as a new raw material for cosmetics in China,and its safety is also under monitoring.This paper systematically reviewed the basic properties,skin care functions and the safety of its application in cosmetics,aiming to provide theoretical reference for the development and application of NMN.
文摘In order to search an appropriate evaluation method for the soothing effect of cosmetics,the LPS-induced macrophage model,SDS-stimulated zebrafish embryos model and the clinical assessment were used.The results showed that the concentration of NO and IL-6 was significantly reduced in LPS-induced RAW264.7 cells when applied to two essences.The inhibition rate of NO-release was 85.87%and 84.57%,while IL-6 was 44.18%and 38.76%,respectively.Furthermore,the spontaneous rotating of zebrafish embryos was significantly decreased to 51.85%and 76.54%in SDS-stimulated zebrafish embryos model.In the 28 days of clinical assessment,the concentration of hydration was significantly increased to 55.56%and 39.61%,while the erythrodesis was significantly decreased to 4.75%and 6.68%.This indicates that the three evaluation methods of soothing efficacy in this research were effective,and can be used in the evaluation of cosmetics.
文摘Borneol,as a traditional natural permeation enhancer,has been widely used to promote the transdermal absorption of active ingredients.The mechanism of borneol in promoting permeation by destroying the highly ordered lipid structure of the lipid layer and by destroying the hydrogen-bond network was described.The application of borneol in promoting the transdermal absorption of the active ingredients of traditional Chinese medicine and chemical drugs was introduced.The application of borneol as a natural ingredient added to functional cosmetics was summarized,and its effects on skin-spot treatment,acne skin care,eczema skin care,skin repair and anti-oxidation were introduced.Finally,the possible problems in the application of borneol in cosmetics were put forward,and the application prospect of borneol in the development of cosmetics was given。
文摘An ultrahigh performance liquid chromatography-triple quadrupole tandem mass spectrometry(UPLC-MS/MS)was established to quickly and accurately determine the content of oleuropein in cosmetics.The samples were extracted with methanol-aqueous solution,and the mobile phase with methanol-formic acid solution(0.1 mol/L)=40∶60 was separated by Agilent ZORBAX Eclipse Plus C18(2.1 mm×50 mm×1.8μm-Micron)column temperature 30℃,flow rate 0.3 mL/min.The MS end was detected by electrospray negative mode ionization(ESI-)and multiple reaction monitoring(MRM)mode.The results show a good linear relationship in the range of 0.002~5 mg/L,with a correlation coefficient R2 of 0.999,5.Method recovery range from 84.2%~107.6%and the relative standard deviation RSD is 5.8%.The detection time is 5 min,the detection limit is 0.000,6 mg/L,and the limit of quantification is 0.002 mg/L.This method has the advantages of convenient operation,low quantification limit,high precision and good repeatability,and is suitable for measuring the content of oleuropein in many kinds of cosmetics.
文摘On April 7th,2023,the supervisory department of Xuhui district published the first Guidance to“Cosmetics Samples”for the First Time(Trial).It unified the management requirement regarding cosmetics samples,guided managers to develop responsibility awareness and prevent and advert risks beforehand.Besides,it identified the definition of“cosmetics samples”.
文摘Cosmetic companies are trying to include more sustainability in their strategies. But, showing commitment is always a challenge for them. This work consists in showing the degree of commitment of cosmetic companies in their marketing practices. The qualitative study carried out aims to determine the level of their commitment in terms of sustainability, based on 10 websites of “sustainable” cosmetics companies that sell their products online, and on defining sustainability criteria for each variable of the marketing mix. The results indicate that the majority of the companies analyzed are aware of the importance of sustainability and have taken measures to have a positive impact on the economy, society and the environment. The companies have made considerable efforts in “product” and “communication” strategies, but additional improvements can be envisaged for “price” and “distribution” strategies.
文摘On April 10,2023,the Shanghai Municipal Medical Products Administration issued a notice on the public consultation of the“Shanghai Pudong New Area General Cosmetics On-site Personalized Service Review Rules(for trial implementation)”(draft for comment),marking the public call for comments from April 3 to May 2,2023.
文摘With the advancement of economic globalization,the flow of commodities from one country to another has become closer and closer.Especially in recent years,the logistics industry has been developing rapidly,overseas purchasing agents and cross-border online shopping have been enormously prevailing,and accordingly more and more British and American cosmetics expect to occupy a place in the huge market of China.Therefore,it is particularly important to explore the Chinese translation strategies for British and American cosmetic brands.Based on the theory of reception aesthetics,this thesis takes the corpus Estee Lauder,La mer,and other famous cosmetics brands.The thesis proposes several methods for translating cosmetic brands:transliteration for proper names like person or geography names;free translation to recreate brand aesthetics;creative translation for new brands;and adapted translation for divergence in language habits.Therefore,this thesis is of theoretical and practical significance as far as the field of cosmetics is concerned.
文摘To evaluate and discuss two novels in vitro alternative tests which based on the 2nd and 4th event of the AOP in skin sensitization and their application in skin sensitization evaluation of cosmetics in vitro.The DSens(DSens method)and Jurkat(TCPA method)were used as the test models and 9 of reference chemicals and 12 kinds of cosmetic products were used to confirm and assess the application capability in skin sensitization.The results showed that the DSens method was more sensitive to the reference chemicals compare to the TCPA method.All the results of cosmetic products showed a high consistency between these two assays and h-CLAT or in vivo assay.As the new screening method for skin sensitization evaluation of cosmetics,the in vitro alternative tests based on AOP have certain effectiveness.The reasonable combination strategy can bring a bright future for the development and application of animal alternative test in China.
文摘This article is based on data analysis from 2012 to 2019 of imported non-special-use cosmetics registration quantity,special-use cosmetics registration quantity,children's cosmetics registration quantity,etc.And also based on the Regulation on Supervision and Administration of Cosmetics(Draft),and so on.This article will briefly discuss the influence of the new trend of Chinese cosmetics regulations on the development of the cosmetics industry.According to data analysis,the pre-market approval process for cosmetics is closely related to the annual increase in the new product registrations quantity.Since March 1st,2017,the reform of the imported non-special-use cosmetics registration was first initiated in Pudong New Area in Shanghai,the imported cosmetics registration quantity has increased significantly,so as the non-special-use children’s registration.Under the background of no obvious change in the pre-marketing approval process of imported special-use cosmetics,there is no significant increase in the quantity of annual registration.Among the nine categories of special-use cosmetics,sunscreen and whitening cosmetics accounted for the highest proportion,followed by hair dyeing.For the hair-growing,breast beauty,fitness categories of special-use cosmetics,the registration quantity each year was very low due to the low approval rate,long approval process and high testing costs,etc.According to the new trend of Chinese cosmetics regulations,the idea of cosmetics supervision and administration is changing from focusing on pre-market approval procedures to focusing on post-market surveillance.
文摘An effective and environmentally friendly method based on ionic liquid-based ultrasound-assisted emulsification microextraction(IL-USAEME) and high performance liquid chromatography (HPLC) has been developed for the determination of nine hormones including three glucocorticoids, one androgen and five progestogens in cosmetics. Several factors that affect the extraction efficiency, such as the kinds and volume of ionic liquid, salt concentration, ultrasonic power and time, and centrifugation time were investigated and optimized. Under the optimum extraction condition, the recoveries of analytes ranged from 85.97% to 108.84% except prednisolone (62.30%). The intraday and interday precision was below 2.51% and 3.30%, respectively.
文摘As nanotechnology finds new applications, the formulation and use of nano-particulate structures in the production of cosmetics and cosmeceuticals keeps increasing. Nano-sized materials such as cubosomes, nanodots, liposomes, dendrimers, nano-emulsions are now becoming regular ingredients in the cosmetic space. These nanoparticle-based cosmetics or nano-cosmeceuticals have extended the boundaries of the applications of cosmetics in managing conditions of wrinkling, dehydrated and inelastic skin associated with aging and dispersed hyperpigmentation. With so many claims by giant cosmetic manufacturers on the several possibilities achievable by such products containing these, there remain valid questions needing answers. Such includes: what are the actual facts as opposed to unfounded expectations on use of nano-materials in cosmetics? What are the peculiar properties of Nano-sized structures? Any potential or actual health risks associated with nanoparticle-incorporated cosmetic products? What roles are the regulating authorities and academic researchers playing in the light of all these developments? This review attempts to answer these questions, taking a look at the updates on nano-sized materials used in cosmetics, while presenting actual advances made in nano-cosmetics amidst the seemingly not too obvious hidden risks.
文摘The hexagonal boron nitride has been well investigated. Its layered structure is similar to that of graphite. In the manufacture of cosmetics, this structure is intended to improve the appearance, sensory aspect and makes it easy to mix excipients contained in the formulation in the mixture process. In cosmetology, the efficiency and the penetration of active substances into skin are known to be directly related to the particle size. However, only recently their nanostructured properties have been explored. In this work, the synthesis of hexagonal boron nitride in the nanoscale, its composition, structure, morphology and potential for future application in sunscreens are being investigated. The boron nitride was synthesized from boric acid and melamine to a heat treatment at 1600℃. The crystal structure was characterized by (XRD) and its morphology was examined by (SEM) and (TEM);the chemical composition was studied by (FTIR), (EDS) and (EELS), the texture characterization by (BET) and its potential in sunscreens by (FTIR and UV/VIS). Results have shown that boron nitride may be synthesized in the nanoscale and that this material has the potential to be incorporated into cosmetics.
文摘The performance and formation mechanism of sensitive skin were summarized. Various evaluation methods for soothing skin cosmetics such as physical and chemical methods, biochemical methods, cell biological methods, three-dimensional recombinant skin model alternative method, animal experiment method, subjective evaluation, semi subjective evaluation and objective instrument evaluation method were introduced. The new idea of soothing efficacy evaluation was proposed and the development direction was put forward.
