Synaptic crosstalk is a prevalent phenomenon among neuronal synapses,playing a crucial role in the transmission of neural signals.Therefore,considering synaptic crosstalk behavior and investigating the dynamical behav...Synaptic crosstalk is a prevalent phenomenon among neuronal synapses,playing a crucial role in the transmission of neural signals.Therefore,considering synaptic crosstalk behavior and investigating the dynamical behavior of discrete neural networks are highly necessary.In this paper,we propose a heterogeneous discrete neural network(HDNN)consisting of a three-dimensional KTz discrete neuron and a Chialvo discrete neuron.These two neurons are coupled mutually by two discrete memristors and the synaptic crosstalk is considered.The impact of crosstalk strength on the firing behavior of the HDNN is explored through bifurcation diagrams and Lyapunov exponents.It is observed that the HDNN exhibits different coexisting attractors under varying crosstalk strengths.Furthermore,the influence of different crosstalk strengths on the synchronized firing of the HDNN is investigated,revealing a gradual attainment of phase synchronization between the two discrete neurons as the crosstalk strength decreases.展开更多
Rice(Oryza sativa)plant architecture and grain shape,which determine grain quality and yield,are modulatedby auxin and brassinosteroid via regulation of cell elongation and proliferation.We review the signaltransducti...Rice(Oryza sativa)plant architecture and grain shape,which determine grain quality and yield,are modulatedby auxin and brassinosteroid via regulation of cell elongation and proliferation.We review the signaltransduction of these hormones and the crosstalk between their signals on the regulation of rice plantarchitecture and grain shape.展开更多
【目的】探究中华鳖(Pelodiscus sinensis)甘露糖受体C2(Mannose receptor C type 2)基因PsMRC2在应答嗜水气单胞菌(Aeromonas hydrophila)感染中的免疫功能,为中华鳖抗细菌感染的免疫机制研究提供理论依据。【方法】通过PCR克隆PsMRC2...【目的】探究中华鳖(Pelodiscus sinensis)甘露糖受体C2(Mannose receptor C type 2)基因PsMRC2在应答嗜水气单胞菌(Aeromonas hydrophila)感染中的免疫功能,为中华鳖抗细菌感染的免疫机制研究提供理论依据。【方法】通过PCR克隆PsMRC2基因开放阅读框(ORF)序列,对其进行生物信息学和系统发育进化分析,并以实时荧光定量PCR检测PsMRC2基因在中华鳖各组织中表达谱及嗜水气单胞菌感染后的时序表达。【结果】PsMRC2基因ORF序列为4086 bp,共编码1361个氨基酸残基。PsMRC2蛋白结构域包括1个纤连蛋白Ⅱ型(FNⅡ)结构域(第61~109位氨基酸)、8个串联的C型凝集素(CLECT)结构域(第116~1276位氨基酸)、1个跨膜结构域(第1295~1317位氨基酸)。通过SOMPA预测得到PsMRC2蛋白二级结构包含706个无规则卷曲(占51.87%)、302个延伸链(占22.19%)、289个α-螺旋(占21.23%)和64个β-转角(占4.70%);SWISS-MODEL预测PsMRC2蛋白三级结构匹配的模板与PsMRC2氨基酸序列相似性为90%,预测结果可信。基于PsMRC2蛋白氨基酸序列相似性构建的系统发育进化树显示,中华鳖与龟类的亲缘关系最近,而与鱼类相距较远。PsMRC2基因在中华鳖的心脏、肝脏、脾脏、肾脏、肠道、肌肉、脑和肺脏组织中均有表达,以脾脏组织中的相对表达量最高。感染嗜水气单胞菌后,PsMRC2基因在中华鳖肝脏、脾脏、肾脏和肠道组织中的相对表达量均呈上调趋势。【结论】PsMRC2基因在进化上较保守,广泛表达于中华鳖各组织中,参与中华鳖抗细菌感染的免疫应答过程。展开更多
目的:探究在替牙列期,对深覆牙合的患儿行MRC(Myofunctional research company)早期矫治后,其软组织及硬组织的变化,评价MRC肌功能训练器对于深覆牙合病例的早期治疗效果,以期为深覆牙合病例的早期矫治提供依据。方法:回顾性分析2019年1...目的:探究在替牙列期,对深覆牙合的患儿行MRC(Myofunctional research company)早期矫治后,其软组织及硬组织的变化,评价MRC肌功能训练器对于深覆牙合病例的早期治疗效果,以期为深覆牙合病例的早期矫治提供依据。方法:回顾性分析2019年12月-2020年8月于苏州大学附属口腔医院就诊的50例替牙期中重度牙性深覆牙合患儿的临床资料,早期应用MRC肌功能训练器,比较其矫治前后硬组织及软组织变化,分析其前后改变的相关性。结果:治疗前后软组织测量值Z角,上唇E线距,下唇E线距差异无统计学意义(P>0.05),治疗前后硬组织测量值SNA、ANB、NP-FH、NA-PA、MP-FH、Y轴角、U1-L1、U1-NA、U1-NA、L1-MP、Po-NB距、FMA(FH-MP)差异均无统计学意义(P>0.05);治疗后,SNB、L1-NB、L1-NB均大于治疗前,而覆牙合小于治疗前,差异均有统计学意义(P<0.05)。结论:MRC肌功能训练器可显著减小替牙期患儿的中重度前牙深覆牙合,同时可以增加下前牙唇倾度,改善下颌后缩。展开更多
Plasmacytoid dendritic cells(pDCs)are a pioneer cell type that produces type I interferon(IFN-I)and promotes antiviral immune responses.However,they are tolerogenic and,when recruited to the tumor microenvironment(TME...Plasmacytoid dendritic cells(pDCs)are a pioneer cell type that produces type I interferon(IFN-I)and promotes antiviral immune responses.However,they are tolerogenic and,when recruited to the tumor microenvironment(TME),play complex roles that have long been a research focus.The interactions between p DCs and other components of the TME,whether direct or indirect,can either promote or hinder tumor development;consequently,p DCs are an intriguing target for therapeutic intervention.This review provides a comprehensive overview of p DC crosstalk in the TME,including crosstalk with various cell types,biochemical factors,and microorganisms.An in-depth understanding of p DC crosstalk in TME should facilitate the development of novel p DC-based therapeutic methods.展开更多
Liver disease has become a leading cause of death,particularly in the West,where it is attributed to more than two million deaths annually.The correlation between gut microbiota and liver disease is still not fully un...Liver disease has become a leading cause of death,particularly in the West,where it is attributed to more than two million deaths annually.The correlation between gut microbiota and liver disease is still not fully understood.However,it is well known that gut dysbiosis accompanied by a leaky gut causes an increase in lipopolysaccharides in circulation,which in turn evoke massive hepatic inflammation promoting liver cirrhosis.Microbial dysbiosis also leads to poor bile acid metabolism and low short-chain fatty acids,all of which exacerbate the inflammatory response of liver cells.Gut microbial homeostasis is maintained through intricate processes that ensure that commensal microbes adapt to the low oxygen potential of the gut and that they rapidly occupy all the intestinal niches,thus outcompeting any potential pathogens for available nutrients.The crosstalk between the gut microbiota and its metabolites also guarantee an intact gut barrier.These processes that protect against destabilization of gut microbes by potential entry of pathogenic bacteria are collectively called colonization resistance and are equally essential for liver health.In this review,we shall investigate how the mechanisms of colonization resistance influence the liver in health and disease and the microbial-liver crosstalk potential as therapeutic target areas.展开更多
Based on single-cell sequencing of the hippocampi of 5×familiar Alzheimer's disease(5×FAD)and wild type mice at 2-,12-,and 24-month of age,we found an increased percentage of microglia in aging and Alzhe...Based on single-cell sequencing of the hippocampi of 5×familiar Alzheimer's disease(5×FAD)and wild type mice at 2-,12-,and 24-month of age,we found an increased percentage of microglia in aging and Alzheimer's disease(AD)mice.Blood brain barrier injury may also have contributed to this increase.Immune regulation by microglia plays a major role in the progression of aging and AD,according to the functions of 41 intersecting differentially expressed genes in microglia.Signaling crosstalk between C−C motif chemokine ligand(CCL)and major histocompatibility complex-1 bridges intercellular communication in the hippocampus during aging and AD.The amyloid precursor protein(APP)and colony stimulating factor(CSF)signals drive 5×FAD to deviate from aging track to AD occurrence among intercellular communication in hippocampus.Microglia are involved in the progression of aging and AD can be divided into 10 functional types.The strength of the interaction among microglial subtypes weakened with aging,and the CCL and CSF signaling pathways were the fundamental bridge of communication among microglial subtypes.展开更多
The precise control and manipulation of the qubit state are vital for quantum simulation and quantum computation.In superconducting circuits,one notorious error comes from the crosstalk of microwave signals applied to...The precise control and manipulation of the qubit state are vital for quantum simulation and quantum computation.In superconducting circuits,one notorious error comes from the crosstalk of microwave signals applied to different qubit control lines.In this work,we present a method for the calibration and cancellation of the microwave crosstalk and experimentally demonstrate its effectiveness in a superconducting 10-qubit chain.The method is convenient and efficient especially for calibrating the microwave crosstalk with large amplitudes and variations,which can be performed successively to reduce the microwave crosstalk by two to three orders.The qubit chain with microwave driving is governed by one-dimensional(1D)Bose-Hubbard model in transverse field,which is nonintegrable and shows thermalization behaviour during the time evolution from certain initial states.Such thermalization process is observed with excellent agreement between experiment and theory further confirming the effective global cancellation of the microwave crosstalk.展开更多
基金Project supported by the Key Projects of Hunan Provincial Department of Education(Grant No.23A0133)the Natural Science Foundation of Hunan Province(Grant No.2022JJ30572)the National Natural Science Foundations of China(Grant No.62171401).
文摘Synaptic crosstalk is a prevalent phenomenon among neuronal synapses,playing a crucial role in the transmission of neural signals.Therefore,considering synaptic crosstalk behavior and investigating the dynamical behavior of discrete neural networks are highly necessary.In this paper,we propose a heterogeneous discrete neural network(HDNN)consisting of a three-dimensional KTz discrete neuron and a Chialvo discrete neuron.These two neurons are coupled mutually by two discrete memristors and the synaptic crosstalk is considered.The impact of crosstalk strength on the firing behavior of the HDNN is explored through bifurcation diagrams and Lyapunov exponents.It is observed that the HDNN exhibits different coexisting attractors under varying crosstalk strengths.Furthermore,the influence of different crosstalk strengths on the synchronized firing of the HDNN is investigated,revealing a gradual attainment of phase synchronization between the two discrete neurons as the crosstalk strength decreases.
基金the National Natural Science Foundation of China(32370248)the Jiangsu Seed Industry Revitalization Project(JBGS[2021]001)a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
文摘Rice(Oryza sativa)plant architecture and grain shape,which determine grain quality and yield,are modulatedby auxin and brassinosteroid via regulation of cell elongation and proliferation.We review the signaltransduction of these hormones and the crosstalk between their signals on the regulation of rice plantarchitecture and grain shape.
文摘【目的】探究中华鳖(Pelodiscus sinensis)甘露糖受体C2(Mannose receptor C type 2)基因PsMRC2在应答嗜水气单胞菌(Aeromonas hydrophila)感染中的免疫功能,为中华鳖抗细菌感染的免疫机制研究提供理论依据。【方法】通过PCR克隆PsMRC2基因开放阅读框(ORF)序列,对其进行生物信息学和系统发育进化分析,并以实时荧光定量PCR检测PsMRC2基因在中华鳖各组织中表达谱及嗜水气单胞菌感染后的时序表达。【结果】PsMRC2基因ORF序列为4086 bp,共编码1361个氨基酸残基。PsMRC2蛋白结构域包括1个纤连蛋白Ⅱ型(FNⅡ)结构域(第61~109位氨基酸)、8个串联的C型凝集素(CLECT)结构域(第116~1276位氨基酸)、1个跨膜结构域(第1295~1317位氨基酸)。通过SOMPA预测得到PsMRC2蛋白二级结构包含706个无规则卷曲(占51.87%)、302个延伸链(占22.19%)、289个α-螺旋(占21.23%)和64个β-转角(占4.70%);SWISS-MODEL预测PsMRC2蛋白三级结构匹配的模板与PsMRC2氨基酸序列相似性为90%,预测结果可信。基于PsMRC2蛋白氨基酸序列相似性构建的系统发育进化树显示,中华鳖与龟类的亲缘关系最近,而与鱼类相距较远。PsMRC2基因在中华鳖的心脏、肝脏、脾脏、肾脏、肠道、肌肉、脑和肺脏组织中均有表达,以脾脏组织中的相对表达量最高。感染嗜水气单胞菌后,PsMRC2基因在中华鳖肝脏、脾脏、肾脏和肠道组织中的相对表达量均呈上调趋势。【结论】PsMRC2基因在进化上较保守,广泛表达于中华鳖各组织中,参与中华鳖抗细菌感染的免疫应答过程。
文摘目的:探究在替牙列期,对深覆牙合的患儿行MRC(Myofunctional research company)早期矫治后,其软组织及硬组织的变化,评价MRC肌功能训练器对于深覆牙合病例的早期治疗效果,以期为深覆牙合病例的早期矫治提供依据。方法:回顾性分析2019年12月-2020年8月于苏州大学附属口腔医院就诊的50例替牙期中重度牙性深覆牙合患儿的临床资料,早期应用MRC肌功能训练器,比较其矫治前后硬组织及软组织变化,分析其前后改变的相关性。结果:治疗前后软组织测量值Z角,上唇E线距,下唇E线距差异无统计学意义(P>0.05),治疗前后硬组织测量值SNA、ANB、NP-FH、NA-PA、MP-FH、Y轴角、U1-L1、U1-NA、U1-NA、L1-MP、Po-NB距、FMA(FH-MP)差异均无统计学意义(P>0.05);治疗后,SNB、L1-NB、L1-NB均大于治疗前,而覆牙合小于治疗前,差异均有统计学意义(P<0.05)。结论:MRC肌功能训练器可显著减小替牙期患儿的中重度前牙深覆牙合,同时可以增加下前牙唇倾度,改善下颌后缩。
基金supported by grants from the China Postdoctoral Science Foundation(Grant No.2022M712880)the Program of the Major Research Plan of the National Natural Science Foundation of China(Grant No.91942314)the National Natural Science Foundation of China(Grant No.82001659).
文摘Plasmacytoid dendritic cells(pDCs)are a pioneer cell type that produces type I interferon(IFN-I)and promotes antiviral immune responses.However,they are tolerogenic and,when recruited to the tumor microenvironment(TME),play complex roles that have long been a research focus.The interactions between p DCs and other components of the TME,whether direct or indirect,can either promote or hinder tumor development;consequently,p DCs are an intriguing target for therapeutic intervention.This review provides a comprehensive overview of p DC crosstalk in the TME,including crosstalk with various cell types,biochemical factors,and microorganisms.An in-depth understanding of p DC crosstalk in TME should facilitate the development of novel p DC-based therapeutic methods.
文摘Liver disease has become a leading cause of death,particularly in the West,where it is attributed to more than two million deaths annually.The correlation between gut microbiota and liver disease is still not fully understood.However,it is well known that gut dysbiosis accompanied by a leaky gut causes an increase in lipopolysaccharides in circulation,which in turn evoke massive hepatic inflammation promoting liver cirrhosis.Microbial dysbiosis also leads to poor bile acid metabolism and low short-chain fatty acids,all of which exacerbate the inflammatory response of liver cells.Gut microbial homeostasis is maintained through intricate processes that ensure that commensal microbes adapt to the low oxygen potential of the gut and that they rapidly occupy all the intestinal niches,thus outcompeting any potential pathogens for available nutrients.The crosstalk between the gut microbiota and its metabolites also guarantee an intact gut barrier.These processes that protect against destabilization of gut microbes by potential entry of pathogenic bacteria are collectively called colonization resistance and are equally essential for liver health.In this review,we shall investigate how the mechanisms of colonization resistance influence the liver in health and disease and the microbial-liver crosstalk potential as therapeutic target areas.
基金supported by grants from the Key R&D Plan of the Science and Technology Plan of Tibet Autonomous Region,China(Grant No.:XZ202201ZY0026G)the Science and Technology Cooperation Project of Shandong Provincial Department of Science and Technology for Counterpart Assistance to Tibet,China(Grant No.:YDZX2021083)+1 种基金the National Natural Science Foundation of China(Grant No.:82205078)the Natural Science Foundation of Shandong Province,China(Grant No.:ZR2021QH157).
文摘Based on single-cell sequencing of the hippocampi of 5×familiar Alzheimer's disease(5×FAD)and wild type mice at 2-,12-,and 24-month of age,we found an increased percentage of microglia in aging and Alzheimer's disease(AD)mice.Blood brain barrier injury may also have contributed to this increase.Immune regulation by microglia plays a major role in the progression of aging and AD,according to the functions of 41 intersecting differentially expressed genes in microglia.Signaling crosstalk between C−C motif chemokine ligand(CCL)and major histocompatibility complex-1 bridges intercellular communication in the hippocampus during aging and AD.The amyloid precursor protein(APP)and colony stimulating factor(CSF)signals drive 5×FAD to deviate from aging track to AD occurrence among intercellular communication in hippocampus.Microglia are involved in the progression of aging and AD can be divided into 10 functional types.The strength of the interaction among microglial subtypes weakened with aging,and the CCL and CSF signaling pathways were the fundamental bridge of communication among microglial subtypes.
基金the Key-Area Research and Development Program of Guangdong Province,China(Grant No.2018B030326001)the National Natural Science Foundation of China(Grant No.11874063),the National Natural Science Foundation of China(Grant No.11890704)+3 种基金the National Natural Science Foundation of China(Grant Nos.11934018 and T2121001)the Natural Science Foundation of Beijing(Grant No.Z190012)Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB28000000)Beijing Natural Science Foundation(Grant No.Z200009)。
文摘The precise control and manipulation of the qubit state are vital for quantum simulation and quantum computation.In superconducting circuits,one notorious error comes from the crosstalk of microwave signals applied to different qubit control lines.In this work,we present a method for the calibration and cancellation of the microwave crosstalk and experimentally demonstrate its effectiveness in a superconducting 10-qubit chain.The method is convenient and efficient especially for calibrating the microwave crosstalk with large amplitudes and variations,which can be performed successively to reduce the microwave crosstalk by two to three orders.The qubit chain with microwave driving is governed by one-dimensional(1D)Bose-Hubbard model in transverse field,which is nonintegrable and shows thermalization behaviour during the time evolution from certain initial states.Such thermalization process is observed with excellent agreement between experiment and theory further confirming the effective global cancellation of the microwave crosstalk.
