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Effect of drying-wetting cycles on pore characteristics and mechanical properties of enzyme-induced carbonate precipitation-reinforced sea sand 被引量:3
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作者 Ming Huang Kai Xu +2 位作者 Zijian Liu Chaoshui Xu Mingjuan Cui 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第1期291-302,共12页
Enzyme-induced carbonate precipitation(EICP)is an emanating,eco-friendly and potentially sound technique that has presented promise in various geotechnical applications.However,the durability and microscopic character... Enzyme-induced carbonate precipitation(EICP)is an emanating,eco-friendly and potentially sound technique that has presented promise in various geotechnical applications.However,the durability and microscopic characteristics of EICP-treated specimens against the impact of drying-wetting(D-W)cycles is under-explored yet.This study investigates the evolution of mechanical behavior and pore charac-teristics of EICP-treated sea sand subjected to D-W cycles.The uniaxial compressive strength(UCS)tests,synchrotron radiation micro-computed tomography(micro-CT),and three-dimensional(3D)recon-struction of CT images were performed to study the multiscale evolution characteristics of EICP-reinforced sea sand under the effect of D-W cycles.The potential correlations between microstructure characteristics and macro-mechanical property deterioration were investigated using gray relational analysis(GRA).Results showed that the UCS of EICP-treated specimens decreases by 63.7% after 15 D-W cycles.The proportion of mesopores gradually decreases whereas the proportion of macropores in-creases due to the exfoliated calcium carbonate with increasing number of D-W cycles.The micro-structure in EICP-reinforced sea sand was gradually disintegrated,resulting in increasing pore size and development of pore shape from ellipsoidal to columnar and branched.The gray relational degree suggested that the weight loss rate and UCS deterioration were attributed to the development of branched pores with a size of 100-1000 m m under the action of D-W cycles.Overall,the results in this study provide a useful guidancee for the long-term stability and evolution characteristics of EICP-reinforced sea sand under D-W weathering conditions. 展开更多
关键词 Enzyme-induced carbonate precipitation(EICP) Plant-based urease Drying-wetting(D-W)cycles Microstructure
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Jovian Planet Influence on the Forcing of Sunspot Cycles
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作者 Fred J. Cadieu 《World Journal of Condensed Matter Physics》 CAS 2024年第1期1-9,共9页
The history of our solar system has been greatly influenced by the fact that there is a large gas giant planet, Jupiter that has a nearly circular orbit. This has allowed relics of the early solar system formation to ... The history of our solar system has been greatly influenced by the fact that there is a large gas giant planet, Jupiter that has a nearly circular orbit. This has allowed relics of the early solar system formation to still be observable today. Since Jupiter orbits the Sun with a period of approximately 12 years, it has always been thought that this could be connected to the nearly 11-year periodic peak in the number of sunspots observed. In this paper, the Sun and planets are considered to be moving about a center of mass point as the different planets orbit the Sun. This is the action of gravity that holds the solar system together. The center of mass for the Jupiter-Sun system actually lies outside the Sun. The four gas giant planets dominate such effects and the four gas giant Jovian planets can be projected together to determine an effective distance from the Sun’s center. Taken together these effects do seem to function as a sunspot forcing factor with a periodicity very close to 11 years. These predictions are made without consideration of any details of what is happening in the interior of the Sun. From these estimates, sunspot cycle 25 will be expected to peak in about September-October of 2025. Sunspot cycle 26 should peak in the year March of 2037. 展开更多
关键词 Sun cycles Solar System Formation JUPITER
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Coupling Effect of Cryogenic Freeze-Thaw Cycles and Chloride Ion Erosion Effect in Pre-Cracked Reinforced Concrete
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作者 Yang Li Sibo Jiang Ruixin Lan 《Structural Durability & Health Monitoring》 EI 2024年第3期255-276,共22页
Chloride (Cl−) ion erosion effects can seriously impact the safety and service life of marine liquefied natural gas(LNG) storage tanks and other polar offshore structures. This study investigates the impact of differe... Chloride (Cl−) ion erosion effects can seriously impact the safety and service life of marine liquefied natural gas(LNG) storage tanks and other polar offshore structures. This study investigates the impact of different low-temperaturecycles (20°C, –80°C, and −160°C) and concrete specimen crack widths (0, 0.3, and 0.6 mm) on the Cl−ion diffusion performance through rapid erosion tests conducted on pre-cracked concrete. The results show thatthe minimum temperature and crack width of freeze-thaw cycles enhance the erosive effect of chloride ions. TheCl− ion concentration and growth rate increased with the increasing crack width. Based on the experimental modeland in accordance with Fick’s second law of diffusion, the Cl− ion diffusion equation was modified by introducingcorrection factors in consideration of the freeze-thaw temperature, crack width, and their coupling effect.The experimental and fitting results obtained from this model can provide excellent reference for practical engineeringapplications. 展开更多
关键词 Chloride ions freeze-thaw cycles cracks
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Thermodynamic Performance Analysis of Geothermal Power Plant Based on Organic Rankine Cycle (ORC) Using Mixture of Pure Working Fluids
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作者 Abdul Sattar Laghari Mohammad Waqas Chandio +1 位作者 Laveet Kumar Mamdouh El Haj Assad 《Energy Engineering》 EI 2024年第8期2023-2038,共16页
The selection of working fluid significantly impacts the geothermal ORC’s Efficiency.Using a mixture as a working fluid is a strategy to improve the output of geothermal ORC.In the current study,modelling and thermod... The selection of working fluid significantly impacts the geothermal ORC’s Efficiency.Using a mixture as a working fluid is a strategy to improve the output of geothermal ORC.In the current study,modelling and thermodynamic analysis of ORC,using geothermal as a heat source,is carried out at fixed operating conditions.The model is simulated in the Engineering Equation Solver(EES).An environment-friendly mixture of fluids,i.e.,R245fa/R600a,with a suitable mole fraction,is used as the operating fluid.The mixture provided the most convenient results compared to the pure working fluid under fixed operating conditions.The impact of varying the evaporator pressure on the performance parameters,including energy efficiency,exergy efficiency and net power output is investigated.The system provided the optimal performance once the evaporator pressure reached the maximum value.The efficiencies:Energy and Exergy,and Net Power output of the system are 16.62%,64.08%and 2199 kW for the basic cycle and 20.72%,67.76%and 2326 kW respectively for the regenerative cycle. 展开更多
关键词 Organic rankine cycle internal heat exchanger moderate-temperature geothermal source mixture of the fluid EXERGY
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Frost heaving force considering synchronous damage to tunnel lining and surrounding rocks under freeze—thaw cycles 被引量:1
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作者 LIU Wen-jun LING Tong-hua +1 位作者 HE Wen-chao LIU Xian-jun 《Journal of Mountain Science》 SCIE CSCD 2023年第4期1131-1146,共16页
In areas with seasonal freezing,when the tunnel lining concrete is saturated with water infiltrating the interior,the lining and the surrounding rocks will simultaneously freeze.However,the current calculation of the ... In areas with seasonal freezing,when the tunnel lining concrete is saturated with water infiltrating the interior,the lining and the surrounding rocks will simultaneously freeze.However,the current calculation of the frost heaving force fails to consider the synchronous damage to the lining and surrounding rocks under freeze-thaw cycles.Therefore,as per the elastic calculation model of the frost heaving force and model of steady-state heat transfer of circular tunnels,this study introduces the frost heaving rate of lining and surrounding rocks.First,the analytical solution of frost heaving force is obtained for simultaneous frost heaving of lining and surrounding rocks under any steady-state temperature field.Then,based on the fracture theory and meso-damage mechanics,the damage variables of lining and surrounding rocks under freeze-thaw cycles are extracted,representing their elastic modulus and porosity.Finally,the formula of frost heaving force for synchronous damage to the lining and surrounding rocks at any steady-state temperature field is obtained.The calculation results demonstrate that the lower the temperature inside the lining,the greater the frost heaving force.With the increasing number of freeze-thaw cycles,frost heaving force tends to gradually increase initially,reaching a peak value at 85 freeze-thaw cycles,decreasing to 80%of the peak value at 140 cycles before reaching a constant value.The lining participates in frost heaving,increasing the frost heaving force.The initial increase rate of frost heaving force is 15.7%.Changing the fitting coefficients s1 and s2 of the lining and surrounding rocks can effectively control the magnitude of the frost heaving force in the tunnels. 展开更多
关键词 Freeze-thaw cycles Frost heaving force Concrete lining Tunnel surrounding rock Synchronous damage
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Dynamic simulation analysis of molten salt reactor-coupled air-steam combined cycle power generation system 被引量:2
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作者 Jing-Lei Huang Guo-Bin Jia +3 位作者 Li-Feng Han Wen-Qian Liu Li Huang Zheng-Han Yang 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第2期222-233,共12页
A nonlinear dynamic simulation model based on coordinated control of speed and flow rate for the molten salt reactor and combined cycle systems is proposed here to ensure the coordination and stability between the mol... A nonlinear dynamic simulation model based on coordinated control of speed and flow rate for the molten salt reactor and combined cycle systems is proposed here to ensure the coordination and stability between the molten salt reactor and power system.This model considers the impact of thermal properties of fluid variation on accuracy and has been validated with Simulink.This study reveals the capability of the control system to compensate for anomalous situations and maintain shaft stability in the event of perturbations occurring in high-temperature molten salt tank outlet parameters.Meanwhile,the control system’s impact on the system’s dynamic characteristics under molten salt disturbance is also analyzed.The results reveal that after the disturbance occurs,the controlled system benefits from the action of the control,and the overshoot and disturbance amplitude are positively correlated,while the system power and frequency eventually return to the initial values.This simulation model provides a basis for utilizing molten salt reactors for power generation and maintaining grid stability. 展开更多
关键词 Molten salt reactor Combined cycle Dynamic characteristic CONTROL
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车用小型化内燃机余热回收ORC系统试验 被引量:1
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作者 石晓磊 高妍 +1 位作者 田华 王轩 《内燃机学报》 EI CAS CSCD 北大核心 2024年第2期185-191,共7页
基于有机朗肯循环(ORC)原理,针对车用内燃机余热回收系统,搭建了集成化试验台架并开展了台架综合性能试验,探究了内燃机余热回收ORC系统小型化优势和上车应用的潜力.结果表明:设计搭建的试验台架主体尺寸为800 mm×750 mm×620 ... 基于有机朗肯循环(ORC)原理,针对车用内燃机余热回收系统,搭建了集成化试验台架并开展了台架综合性能试验,探究了内燃机余热回收ORC系统小型化优势和上车应用的潜力.结果表明:设计搭建的试验台架主体尺寸为800 mm×750 mm×620 mm,质量为200 kg左右,具有一定的小型化优势;ORC系统整体运行具有较好的稳定性和可靠性,在发动机转速为1300 r/min、转矩为600 N·m工况下,工质质量流量为0.1716 kg/s,蒸发压力达到1.26 MPa,膨胀机运行转速调整为1456 r/min时,ORC系统的输出功率达到2.64 kW. 展开更多
关键词 车用内燃机 余热回收 有机朗肯循环
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Durable K-ion batteries with 100% capacity retention up to 40,000 cycles 被引量:1
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作者 Xianlu Lu Zhao Liang +6 位作者 Zhi Fang Dongdong Zhang Yapeng Zheng Qiao Liu Dingfa Fu Jie Teng Weiyou Yang 《Carbon Energy》 SCIE EI CAS CSCD 2024年第5期201-212,共12页
Currently,the major challenge in terms of research on K-ion batteries is to ensure that they possess satisfactory cycle stability and specific capacity,especially in terms of the intrinsically sluggish kinetics induce... Currently,the major challenge in terms of research on K-ion batteries is to ensure that they possess satisfactory cycle stability and specific capacity,especially in terms of the intrinsically sluggish kinetics induced by the large radius of K+ions.Here,we explore high-performance K-ion half/full batteries with high rate capability,high specific capacity,and extremely durable cycle stability based on carbon nanosheets with tailored N dopants,which can alleviate the change of volume,increase electronic conductivity,and enhance the K+ion adsorption.The as-assembled K-ion half-batteries show an excellent rate capability of 468 mA h g^(−1) at 100 mA g^(−1),which is superior to those of most carbon materials reported to date.Moreover,the as-assembled half-cells have an outstanding life span,running 40,000 cycles over 8 months with a specific capacity retention of 100%at a high current density of 2000 mA g^(−1),and the target full cells deliver a high reversible specific capacity of 146 mA h g^(−1) after 2000 cycles over 2 months,with a specific capacity retention of 113%at a high current density of 500 mA g^(−1),both of which are state of the art in the field of K-ion batteries.This study might provide some insights into and potential avenues for exploration of advanced K-ion batteries with durable stability for practical applications. 展开更多
关键词 carbon nanosheet cycle stability K-ion batteries rate performance specific capacity
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耦合太阳能氨气分解制氢过程的MGT-ORC动力系统热力性能分析
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作者 席学章 王秋实 +1 位作者 张汉飞 段立强 《热力发电》 CAS CSCD 北大核心 2024年第3期59-66,共8页
构建高效、无污染的动力发电系统是解决目前能源紧缺和环境污染问题的有效手段。以Capstone公司生产的C65型微型燃气轮机为核心发电部件,耦合了太阳能驱动氨气分解制氢的热化学过程,实现了可再生能源和氨气化学能之间的多能互补,采用有... 构建高效、无污染的动力发电系统是解决目前能源紧缺和环境污染问题的有效手段。以Capstone公司生产的C65型微型燃气轮机为核心发电部件,耦合了太阳能驱动氨气分解制氢的热化学过程,实现了可再生能源和氨气化学能之间的多能互补,采用有机朗肯循环(ORC)作为底循环回收微型燃气轮机(微燃机,MGT)产生的烟气余热并发电,实现能量梯级利用。在化工模拟软件Aspen Plus中构建了详细的模拟流程,进行系统热力性能分析,结果表明:通过太阳能和氨气的互补提高了富氢合成气热值,微燃机输出功率为89.95 k W,比参考系统中的C65微燃机多24.95k W;该系统在设计工况下的电效率达到了44.81%,[火用]效率为47.97%,分别比参考系统高出8.51百分点和9.67百分点;系统中最大的?损部件为燃烧室,占到了总[火用]损的41.67%,其次蒸发器和回热器分别占14.31%和11.15%;系统电效率和[火用]效率随着太阳能集热量的增加分别呈减小和增大的趋势。该研究结果可为以氨气为燃料并耦合太阳能的分布式微燃机发电系统提供参考。 展开更多
关键词 太阳能 氨气 制氢 热力性能 微型燃气轮机-有机朗肯循环
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烧结冷却烟气低温余热ORC系统建模与热经济性能 被引量:1
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作者 冯军胜 程新妮 +2 位作者 王欢欢 赵亮 董辉 《烧结球团》 北大核心 2024年第1期93-98,105,共7页
本文以烧结冷却烟气低温余热为有机朗肯循环(organic Rankine cycle,ORC)系统热源,建立超临界ORC系统热力和经济模型,并选取R134a为ORC工质,研究变温热源下膨胀机的进口温度和压力,以及工质冷凝温度对系统热经济性能的影响。研究结果表... 本文以烧结冷却烟气低温余热为有机朗肯循环(organic Rankine cycle,ORC)系统热源,建立超临界ORC系统热力和经济模型,并选取R134a为ORC工质,研究变温热源下膨胀机的进口温度和压力,以及工质冷凝温度对系统热经济性能的影响。研究结果表明:系统净输出功随膨胀机进口温度的增加而增加,随膨胀机进口压力和工质冷凝温度的增加而减小,但系统单位温度的传热量随之均减小。当系统热力参数一定时,热源进口温度越大,系统净输出功和单位温度的传热量越大。在实际操作过程中,存在适宜的热源进口温度和系统热力参数使得ORC系统获得较大的净输出功和较小的单位温度传热量。 展开更多
关键词 烧结矿 余热回收 有机朗肯循环 净输出功 单位温度传热量
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基于小型ORC涡旋膨胀机变工况特性研究及实验验证
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作者 石磊 赵亚珑 彭斌 《热力发电》 CAS CSCD 北大核心 2024年第1期115-123,共9页
涡旋膨胀机作为有机朗肯循环(organic Rankine cycle,ORC)核心部件之一,其运行特性直接影响了ORC的性能。首先,建立了涡旋膨胀机的三维瞬态仿真模型,通过数值模拟的方法,系统地分析了不同工况下吸气压力、排气压力、转速和对涡旋膨胀机... 涡旋膨胀机作为有机朗肯循环(organic Rankine cycle,ORC)核心部件之一,其运行特性直接影响了ORC的性能。首先,建立了涡旋膨胀机的三维瞬态仿真模型,通过数值模拟的方法,系统地分析了不同工况下吸气压力、排气压力、转速和对涡旋膨胀机输出功率和等熵效率的影响;其次,分析了不同工况对涡旋膨胀机瞬态性能的影响,较为全面地分析了其中的机理;最后,通过实验室搭建的ORC低温余热无油发电系统试验台验证了数值模型的准确性,实验结果与数值模拟结果吻合良好,验证了数值模拟方法的可靠性和适用性。研究结果对涡旋膨胀机的设计和优化具有重要的参考价值。 展开更多
关键词 有机朗肯循环 涡旋膨胀机 数值模拟 变工况 实验验证
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Multi-objective optimization and evaluation of supercritical CO_(2) Brayton cycle for nuclear power generation 被引量:1
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作者 Guo-Peng Yu Yong-Feng Cheng +1 位作者 Na Zhang Ping-Jian Ming 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2024年第2期183-209,共27页
The supercritical CO_(2) Brayton cycle is considered a promising energy conversion system for Generation IV reactors for its simple layout,compact structure,and high cycle efficiency.Mathematical models of four Brayto... The supercritical CO_(2) Brayton cycle is considered a promising energy conversion system for Generation IV reactors for its simple layout,compact structure,and high cycle efficiency.Mathematical models of four Brayton cycle layouts are developed in this study for different reactors to reduce the cost and increase the thermohydraulic performance of nuclear power generation to promote the commercialization of nuclear energy.Parametric analysis,multi-objective optimizations,and four decision-making methods are applied to obtain each Brayton scheme’s optimal thermohydraulic and economic indexes.Results show that for the same design thermal power scale of reactors,the higher the core’s exit temperature,the better the Brayton cycle’s thermo-economic performance.Among the four-cycle layouts,the recompression cycle(RC)has the best overall performance,followed by the simple recuperation cycle(SR)and the intercooling cycle(IC),and the worst is the reheating cycle(RH).However,RH has the lowest total cost of investment(C_(tot))of$1619.85 million,and IC has the lowest levelized cost of energy(LCOE)of 0.012$/(kWh).The nuclear Brayton cycle system’s overall performance has been improved due to optimization.The performance of the molten salt reactor combined with the intercooling cycle(MSR-IC)scheme has the greatest improvement,with the net output power(W_(net)),thermal efficiencyη_(t),and exergy efficiency(η_(e))improved by 8.58%,8.58%,and 11.21%,respectively.The performance of the lead-cooled fast reactor combined with the simple recuperation cycle scheme was optimized to increase C_(tot) by 27.78%.In comparison,the internal rate of return(IRR)increased by only 7.8%,which is not friendly to investors with limited funds.For the nuclear Brayton cycle,the molten salt reactor combined with the recompression cycle scheme should receive priority,and the gas-cooled fast reactor combined with the reheating cycle scheme should be considered carefully. 展开更多
关键词 Supercritical CO_(2)Brayton cycle Nuclear power generation Thermo-economic analysis Multi-objective optimization Decision-making methods
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Involvement of the ABA-and H_(2)O_(2)-Mediated Ascorbate-Glutathione Cycle in the Drought Stress Responses of Wheat Roots 被引量:1
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作者 Mengyuan Li Zhongye Gao +2 位作者 Lina Jiang Leishan Chen Jianhui Ma 《Phyton-International Journal of Experimental Botany》 SCIE 2024年第2期329-342,共14页
Abscisic acid(ABA),hydrogen peroxide(H_(2)O_(2)) and ascorbate(AsA)–glutathione(GSH)cycle are widely known for their participation in various stresses.However,the relationship between ABA and H_(2)O_(2) levels and th... Abscisic acid(ABA),hydrogen peroxide(H_(2)O_(2)) and ascorbate(AsA)–glutathione(GSH)cycle are widely known for their participation in various stresses.However,the relationship between ABA and H_(2)O_(2) levels and the AsA–GSH cycle under drought stress in wheat has not been studied.In this study,a hydroponic experiment was conducted in wheat seedlings subjected to 15%polyethylene glycol(PEG)6000–induced dehydration.Drought stress caused the rapid accumulation of endogenous ABA and H_(2)O_(2) and significantly decreased the number of root tips compared with the control.The application of ABA significantly increased the number of root tips,whereas the application of H_(2)O_(2) markedly reduced the number of root tips,compared with that under 15%PEG-6000.In addition,drought stress markedly increased the DHA,GSH and GSSG levels,but decreased the AsA levels,AsA/DHA and GSH/GSSG ratios compared with those in the control.The activities of the four enzymes in the AsA–GSH cycle were also markedly increased under drought stress,including glutathione reductase(GR),ascorbate peroxidase(APX),monodehydroascorbate reductase(MDHAR)and dehydroascorbate reductase(DHAR),compared with those in the control.However,the application of an ABA inhibitor significantly inhibited GR,DHAR and APX activities,whereas the application of an H_(2)O_(2) inhibitor significantly inhibited DHAR and MDHAR activities.Furthermore,the application of ABA inhibitor significantly promoted the increases of H_(2)O_(2) and the application of H_(2)O_(2) inhibitor significantly blocked the increases of ABA,compared with those under 15% PEG-6000.Taken together,the results indicated that ABA and H_(2)O_(2) probably interact under drought stress in wheat;and both of them can mediate drought stress by modulating the enzymes in AsA–GSH cycle,where ABA acts as the main regulator of GR,DHAR,and APX activities,and H_(2)O_(2) acts as the main regulator of DHAR and MDHAR activities. 展开更多
关键词 ABA H_(2)O_(2) AsA-GSH cycle drought stress wheat roots
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有向图上基于层次树索引的最大cycle truss社区搜索
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作者 宗传玉 张纯鹤 夏秀峰 《计算机应用》 CSCD 北大核心 2024年第1期190-198,共9页
社区搜索旨在从信息网络中找出包含用户查询顶点的高内聚连通子图,cycle truss是一种基于cycle三角形的社区搜索模型,而现有的基于索引的cycle truss社区搜索方法存在索引空间大、搜索效率低、社区内聚性低的缺点。为了解决这一问题,提... 社区搜索旨在从信息网络中找出包含用户查询顶点的高内聚连通子图,cycle truss是一种基于cycle三角形的社区搜索模型,而现有的基于索引的cycle truss社区搜索方法存在索引空间大、搜索效率低、社区内聚性低的缺点。为了解决这一问题,提出一种基于层次树索引的最大cycle truss社区搜索方法。首先,提出了k-cycle truss分解算法,并引入了两个重要的概念:cycle三角连通与k-层次等价。基于k-层次等价设计了层次树索引TreeCIndex与表结构索引SuperTable,在此基础上,并基于这两个新的索引,提出了两个高效的cycle truss社区搜索算法。在4个真实数据集上与已有的基于TrussIndex与EquiTruss的社区搜索算法进行了比较,实验结果表明,TreeCIndex与SuperTable比TrussIndex与EquiTruss节省至少41.5%的空间,索引构建的时间节省8.2%至98.3%,且搜索最大cycle truss社区的效率分别高出了一个和两个数量级。 展开更多
关键词 有向图 社区搜索 cycle truss cycle三角形 层次等价 层次树索引
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The MORC2 p.S87L mutation reduces proliferation of pluripotent stem cells derived from a patient with the spinal muscular atrophy-like phenotype by inhibiting proliferation-related signaling pathways 被引量:1
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作者 Sen Zeng Honglan Yang +8 位作者 Binghao Wang Yongzhi Xie Ke Xu Lei Liu Wanqian Cao Xionghao Liu Beisha Tang Mujun Liu Ruxu Zhang 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第1期205-211,共7页
Mutations in the microrchidia CW-type zinc finger protein 2(MORC2)gene are the causative agent of Charcot-Marie-Tooth disease type 2Z(CMT2Z),and the hotspot mutation p.S87L is associated with a more seve re spinal mus... Mutations in the microrchidia CW-type zinc finger protein 2(MORC2)gene are the causative agent of Charcot-Marie-Tooth disease type 2Z(CMT2Z),and the hotspot mutation p.S87L is associated with a more seve re spinal muscular atrophy-like clinical phenotype.The aims of this study were to determine the mechanism of the severe phenotype caused by the MORC2 p.S87L mutation and to explore potential treatment strategies.Epithelial cells were isolated from urine samples from a spinal muscular atrophy(SMA)-like patient[MORC2 p.S87L),a CMT2Z patient[MORC2 p.Q400R),and a healthy control and induced to generate pluripotent stem cells,which were then differentiated into motor neuron precursor cells.Next-generation RNA sequencing followed by KEGG pathway enrichment analysis revealed that differentially expressed genes involved in the PI3K/Akt and MAP K/ERK signaling pathways were enriched in the p.S87L SMA-like patient group and were significantly downregulated in induced pluripotent stem cells.Reduced proliferation was observed in the induced pluripotent stem cells and motor neuron precursor cells derived from the p.S87L SMA-like patient group compared with the CMT2Z patient group and the healthy control.G0/G1 phase cell cycle arrest was observed in induced pluripotent stem cells derived from the p.S87L SMA-like patient.MORC2 p.S87Lspecific antisense oligonucleotides(p.S87L-ASO-targeting)showed significant efficacy in improving cell prolife ration and activating the PI3K/Akt and MAP K/ERK pathways in induced pluripotent stem cells.Howeve r,p.S87L-ASO-ta rgeting did not rescue prolife ration of motor neuron precursor cells.These findings suggest that downregulation of the PI3K/Akt and MAP K/ERK signaling pathways leading to reduced cell proliferation and G0/G1 phase cell cycle arrest in induced pluripotent stem cells might be the underlying mechanism of the severe p.S87L SMA-like phenotype.p.S87L-ASO-targeting treatment can alleviate disordered cell proliferation in the early stage of pluripotent stem cell induction. 展开更多
关键词 antisense oligonucleotides cell cycle arrest Charcot-Marie-Tooth disease 2Z induced pluripotent stem cells MAPK/ERK PI3K/Akt PROLIFERATION spinal muscular atrophy-like
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A Review on Technologies for the Use of CO2 as a Working Fluid in Refrigeration and Power Cycles
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作者 Orelien T. Boupda Hyacinthe D. Tessemo +3 位作者 Isidore B. Nkounda Fongang Francklin G. Nyami Frederic Lontsi Thomas Djiako 《Energy and Power Engineering》 2024年第6期217-256,共40页
The use of carbon dioxide as a working fluid has been the subject of extensive studies in recent years, particularly in the field of refrigeration where it is at the heart of research to replace CFC and HCFC. Its ther... The use of carbon dioxide as a working fluid has been the subject of extensive studies in recent years, particularly in the field of refrigeration where it is at the heart of research to replace CFC and HCFC. Its thermodynamic properties make it a fluid of choice in the efficient use of energy at low and medium temperatures in engine cycles. However, the performance of transcritical CO2 cycles weakens under high temperature and pressure conditions, especially in refrigeration systems;On the other hand, this disadvantage becomes rather interesting in engine cycles where CO2 can be used as an alternative to the organic working fluid in small and medium-sized electrical systems for low quality or waste heat sources. In order to improve the performance of systems operating with CO2 in the field of refrigeration and electricity production, research has made it possible to develop several concepts, of which this article deals with a review of the state of the art, followed by analyzes in-depth and critical of the various developments to the most recent modifications in these fields. Detailed discussions on the performance and technical characteristics of the different evolutions are also highlighted as well as the factors affecting the overall performance of the systems studied. Finally, perspectives on the future development of the use of CO2 in these different cycles are presented. 展开更多
关键词 Refrigeration cycle Power cycle System Performance Transcritical CO2 cycles Working Fluid
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Structure Optimization of a Tesla Turbine Using an Organic Rankine Cycle Technology
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作者 Yongguo Li Caiyin Xu +1 位作者 Can Qin Dingjian Zheng 《Fluid Dynamics & Materials Processing》 EI 2024年第6期1251-1263,共13页
The so-called ORC(Organic Rankine Cycle)heat recovery technology has attracted much attention with regard to medium and low temperature waste heat recovery.In the present study,it is applied to a Tesla turbine.At the ... The so-called ORC(Organic Rankine Cycle)heat recovery technology has attracted much attention with regard to medium and low temperature waste heat recovery.In the present study,it is applied to a Tesla turbine.At the same time,the effects of the disc speed,diameter and inter-disc gap on the internal flow field and output power of the turbine are also investigated by means of CFD(Computational Fluid Dynamics)numerical simulation,by which the pressure,velocity,and output efficiency of the internal flow field are obtained under different internal and external conditions.The highest efficiency(66.4%)is obtained for a number of nozzles equal to 4,a disk thickness of 1 mm,and a gap of 1 mm between the disks.The results of the study serve as a theoretical basis for the structural design and optimization of Tesla turbines. 展开更多
关键词 orc Tesla turbine CFD numerical simulation structural parameters
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Long-Cycle Lithium Batteries with LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) Cathodes above 4.5 V Enabled by Uniform Coating of Nanosized Garnet Electrolytes
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作者 王建群 赵宁 郭向欣 《Chinese Physics Letters》 SCIE EI CAS CSCD 2024年第7期161-175,共15页
The pursuit of high-energy cathode materials has been focused on raising the charging cutoff voltage of nickel (Ni)-rich layered oxide cathode such as LiNi_(0.8)Co_(0.1)Mn_(0.1)O2 (NCM811). However, the NCM811 suffers... The pursuit of high-energy cathode materials has been focused on raising the charging cutoff voltage of nickel (Ni)-rich layered oxide cathode such as LiNi_(0.8)Co_(0.1)Mn_(0.1)O2 (NCM811). However, the NCM811 suffers from rapid capacity fading upon cycling at cutoff voltage higher than 4.5 V, owing to their structural degradation and labile surface reactivity. Surface-coating with solid electrolytes has been recognized as an effective method to mitigate the performance failure of NCM811 at high voltage. Herein, the nano-sized Li_(6.4)La_(3)Ta_(0.6)Zr_(1.4)O_(12) (LLZTO) is uniformly coated on the surface of single-crystal NCM811 particles, accompanied with the long-range Ta^(5+) diffusion into the transition metal layer of NCM811 lattice. It is revealed that the LLZTO coating can not only inhibit the surface reactions of NCM811 with liquid electrolytes but also play an important role in suppressing the bulk microcracking within the NCM811 particles. The incorporation of Ta^(5+) ion expands the lattice spacing and thereby improves the homogeneity of the Li^(+) diffusion in the single-crystal NCM811, which alleviates the mechanical strain and intragranular cracks caused by nonuniform phases-transformation at high charging voltage. The synergy of surface protection and structural stabilization realized by LLZTO coating enables the NCM811-based lithium batteries to achieve a remarkable electrochemical performance. Typically, LLZTO coated NCM811 delivers a high reversible specific capacity of 202.1 mAh⋅g^(−1) with an excellent capacity retention as high as 70% over 1000 cycles upon charging to 4.5 V at 1 C. 展开更多
关键词 coating CYCLING sized
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Bicycle-related traumatic injuries: a retrospective study during COVID-19 pandemic
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作者 Jie Er Janice Soo Yuan Helen Zhang +1 位作者 Gek Hsiang Lim Fatimah Lateef 《World Journal of Emergency Medicine》 SCIE CAS CSCD 2024年第4期256-262,共7页
BACKGROUND:This study aimed to review bicycle-related injuries during the COVID-19 pandemic to assist with reinforcement or implementation of new policies for injury prevention.METHODS:This is a retrospective descript... BACKGROUND:This study aimed to review bicycle-related injuries during the COVID-19 pandemic to assist with reinforcement or implementation of new policies for injury prevention.METHODS:This is a retrospective descriptive analysis of injuries sustained during cycling for patients 18 years old and above who presented to Singapore General Hospital from January to June 2021.Medical records were reviewed and consolidated.Descriptive analyses were used to summarize patient characteristics,and differences in characteristics subgrouped by triage acuity and discharge status were analyzed.RESULTS:The study included 272 patients with a mean age of 43 years and a male predominance(71.7%).Most presented without referrals(88.2%)and were not conveyed by ambulances(70.6%).Based on acuity category,there were 24(8.8%)Priority 1(P1)patients with 7 trauma activations,174(64.0%)and 74(27.2%)P2 and P3 patients respectively.The most common injuries were fractures(34.2%),followed by superficial abrasion/contusion(29.4%)and laceration/wound(19.1%).Thirteen(4.8%)patients experienced head injury and 85 patients(31.3%)were documented to be wearing a helmet.The majority occurred on the roads as traffic accidents(32.7%).Forty-two patients(15.4%)were admitted with a mean length of stay of 4.1 d and 17(6.3%)undergone surgical procedures.Out of 214(78.7%)discharged patients,no re-attendances or mortality were observed.In the subgroup analysis,higher acuity patients were generally older,with higher proportions of head injuries leading to admission.CONCLUSION:Our study highlights significant morbidities in bicycle-related injuries.There is also a high proportion of fractures in the young healthy male population.Injury prevention is paramount and we propose emphasizing helmet use and road user safety. 展开更多
关键词 CYCLING INJURIES Emergency department
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The Impact of Network Topologies and Radio Duty Cycle Mechanisms on the RPL Routing Protocol Power Consumption
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作者 Amal Hkiri Hamzah Faraj +3 位作者 Omar Ben Bahri Mouna Karmani Sami Alqurashi Mohsen Machhout 《Computers, Materials & Continua》 SCIE EI 2024年第5期1835-1854,共20页
The Internet of Things(IoT)has witnessed a significant surge in adoption,particularly through the utilization of Wireless Sensor Networks(WSNs),which comprise small internet-connected devices.These deployments span va... The Internet of Things(IoT)has witnessed a significant surge in adoption,particularly through the utilization of Wireless Sensor Networks(WSNs),which comprise small internet-connected devices.These deployments span various environments and offer a multitude of benefits.However,the widespread use of battery-powered devices introduces challenges due to their limited hardware resources and communication capabilities.In response to this,the Internet Engineering Task Force(IETF)has developed the IPv6 Routing Protocol for Low-power and Lossy Networks(RPL)to address the unique requirements of such networks.Recognizing the critical role of RPL in maintaining high performance,this paper proposes a novel approach to optimizing power consumption.Specifically,it introduces a developed sensor motes topology integrated with a Radio Duty Cycling(RDC)mechanism aimed at minimizing power usage.Through rigorous analysis,the paper evaluates the power efficiency of this approach through several simulations conducted across different network topologies,including random,linear,tree,and elliptical topologies.Additionally,three distinct RDC mechanisms—CXMAC,ContikiMAC,and NullRDC—are investigated to assess their impact on power consumption.The findings of the study,based on a comprehensive and deep analysis of the simulated results,highlight the efficiency of ContikiMAC in power conservation.This research contributes valuable insights into enhancing the energy efficiency of RPL-based IoT networks,ultimately facilitating their widespread deployment and usability in diverse environments. 展开更多
关键词 WSN IoT radio duty cycles TOPOLOGIES
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