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A clinical trial of cytokine induced killer cells treating patients with malignant tumor after radiochemotherapy 被引量:1
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作者 Jing Tian Donghai Teng 《The Chinese-German Journal of Clinical Oncology》 CAS 2010年第11期656-659,共4页
Objective: Our study investigated the immunity changes and life quality changes after the treatment of cytokine induced killer (CIK) cells for patients with malignant tumor after radiochemotherapy, and explored the th... Objective: Our study investigated the immunity changes and life quality changes after the treatment of cytokine induced killer (CIK) cells for patients with malignant tumor after radiochemotherapy, and explored the therapeutic effects of CIK cells on these patients. Methods: Thirty-one patients with malignant tumor after radiochemotherapy were treated with CIK cells. Before and after CIK cells being transfused back, the immunity indexes of the peripheral blood of these cases were detected and the changes of life quality of these cases were compared. Results: After radiochemotherapy, the percentage of CD3+, CD4+ cells declined, the percentage of CD8+ cells rose; the ratio of CD4+/CD8+ declined, and the percentage of CD16+, CD56+ cells declined. As all the above indexes compared with that of normal people, the difference was significant (P < 0.05). After CIK cells therapy, the above indexes improved (P < 0.05). Life quality improved significantly after CIK cells therapy (P < 0.05). Conclusion: Radiochemotherapy can inhibit the immunity in patients with malignant tumor. CIK cells therapy is safe and effective. It may improve the recent immunity and life quality of the patients, which suggesting that it may be an alternative maintenance treatment for patients with malignant tumor after radiochemotherapy. 展开更多
关键词 cytokine induced killer (CIK) immunity malignant tumor RADIOCHEMOTHERAPY
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Effects of Various Factors on Proliferation Capacity and Cytotoxicity of Induced CIK of Patients with Tumor In Vitro 被引量:1
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作者 王晓华 梁红 +5 位作者 隋承光 孟凡东 王杨 蒋涛 付立业 姜又红 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2008年第1期49-52,共4页
Objective: To evaluate effects of different factors on proliferation capacity and cytotoxicity of induced cytokine induced killer (CIK) cells in vitro, so as to provide experimental basis for cell therapy of CIK in... Objective: To evaluate effects of different factors on proliferation capacity and cytotoxicity of induced cytokine induced killer (CIK) cells in vitro, so as to provide experimental basis for cell therapy of CIK in tumor. Methods: Cytometry and MTT assay were used in detecting proliferation capacity and cytotoxicity of CIK. Results: The proliferation capacity and cytotoxicity of CIK in vitro were stronger in the group of low age and serum free medium than in the group of advanced age or serum medium. And the proliferation of CIK in vitro increased with time during a certain period of incubation. Furthermore, CIK had equal cytotoxicity to various tumor cells. Conclusion: Various factors might influence the proliferation capacity and cytotoxicity of CIK of tumor patients in vitro. 展开更多
关键词 CIK Cytokin induced killer Proliferation capacity CYTOTOXICITY cytokine
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Clinical study of co-treatment with DC-CIK cells for advanced solid carcinomas 被引量:4
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作者 Tao Yang Ying Xiang +3 位作者 Yucheng Li Jianghe Shao Qiying Li Huiqing Yu 《The Chinese-German Journal of Clinical Oncology》 CAS 2011年第6期354-359,共6页
Objective: The aim of this study was to observe the therapeutic effect of cytokine induced killer (CIK) cells in combination with dendritic cells (DCs) on advanced solid carcinoma patients. Methods: Isolated per... Objective: The aim of this study was to observe the therapeutic effect of cytokine induced killer (CIK) cells in combination with dendritic cells (DCs) on advanced solid carcinoma patients. Methods: Isolated peripheral blood mononuclear cells (PBMCs) from 110 advanced solid tumor patients. Added granulocyte-macrophage colony-stimulating factor (GM-CSF), tumor necrosis factor-a (TNF-a) and interleukin-4 (IL-4) to adherent cells to induce DCs, and sensitized DCs with antigens of autologous tumor cells or extrinsic tumor cell lines. Cultured suspending cells with interferon-y (IFN-y), interleukin-2 (IL-2) and CD3 monoclonal antibody (CD3 McAb) to prepare CIK cells, then co-cultured with DCs. After analyzing the phenotype and checking tumor markers and immune function, the autologous CIK cells and DCs were transfused into the cancer patients. Results: Forty-two patients with measurable nidus, 2 achieved complete remission (CR), 9 partial remission (PR) and 15 stable disease (SD), while 37 patients with immeasurable nidus, 25 had efficient response. The tumor markers and immune function both improved significantly compared with those before treatment. Conclusion: DCs and CIK cells combinational treatment is safe and effective on advanced solid carcinoma and provide a new and efficacious immunity therapeutic methods for the cancer patients. 展开更多
关键词 NEOPLASMS cytokine induced killer (CIK) cells dendritic cells immunotherapy
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