Precipitation over the Tibetan Plateau and surrounding highlands is a crucial process in the hydrological cycle and is very important for local and downstream ecology,and previous research mainly focused on a certain ...Precipitation over the Tibetan Plateau and surrounding highlands is a crucial process in the hydrological cycle and is very important for local and downstream ecology,and previous research mainly focused on a certain range of timescales.A better understanding of the variability across various timescales,which has been largely ignored,can provide new insight on the regional weather and climate.Here,a north‒south dipole pattern of precipitation shaped by a zonal dipole of the upper-tropospheric temperature is revealed in this region.Both dipole patterns of the precipitation and the accompanied temperature exist from daily to interdecadal scales.The three-dimensional circulation anomalies connecting the temperature and precipitation dipoles are consistent across various timescales.The frequencies of daily events with opposite phases of the temperature dipole modulate the interannual and interdecadal variability in precipitation.The south drying and north wetting pattern over the Tibetan Plateau is an interdecadal manifestation of the precipitation dipole and can be ascribed to the temperature trend favourable for the positive phase of the zonal temperature dipole.The consistent dipole pattern constructs a more complete portrayal of precipitation over the Tibetan Plateau from synoptic scale to climatology.展开更多
BACKGROUND Myasthenia gravis(MG)is an autoimmune disorder caused by neuromuscular junction failure characterized by muscle weakness and fatigability.We herein report a case of MG that received intravascular laser irra...BACKGROUND Myasthenia gravis(MG)is an autoimmune disorder caused by neuromuscular junction failure characterized by muscle weakness and fatigability.We herein report a case of MG that received intravascular laser irradiation of blood(ILIB)interventions and regained muscle power and better quality of life.To our knowledge,no previous study has investigated the benefits of ILIB treatment on patients with MG.We also evaluated the changes in brain perfusion scan and the MG activities of daily living(MG-ADL)and quantitative MG(QMG)scales.CASE SUMMARY A 59-year-old man presented to our outpatient hospital experiencing ptosis,diplopia,fibromyalgia,muscle fatigue,and fluctuating weakness in his limbs for 1 year.Based on his history,physical examination,and laboratory investigations,the final diagnosis was a flare-up of MG with poor endurance and muscle fatigue.The patient agreed to receive ILIB.Brain single-photon emission computed tomography(SPECT)was performed both before and after ILIB therapy.After receiving three courses of ILIB,the brain SPECT images showed greatly increased perfusion of the frontal lobe and anterior cingulate gyri.The patient’s MG-ADL scale score decreased markedly from 17/24 to 3/24.The QMG scale score also decreased remarkably from 32/39 to 9/39.The symptoms of MG became barely detectable and the patient was able to perform his activities of daily living and regain muscle power.CONCLUSION ILIB might have beneficial effects on MG,and brain SPECT images provided direct evidence of a positive correlation between ILIB and clinical performance.展开更多
基金the National Natural Science Foundation of China(42225505,U2142204,91637210)S&T Development Fund of CAMS(2022KJ007,2023KJ033)the Jiangsu Collaborative Innovation Center for Climate Change.
文摘Precipitation over the Tibetan Plateau and surrounding highlands is a crucial process in the hydrological cycle and is very important for local and downstream ecology,and previous research mainly focused on a certain range of timescales.A better understanding of the variability across various timescales,which has been largely ignored,can provide new insight on the regional weather and climate.Here,a north‒south dipole pattern of precipitation shaped by a zonal dipole of the upper-tropospheric temperature is revealed in this region.Both dipole patterns of the precipitation and the accompanied temperature exist from daily to interdecadal scales.The three-dimensional circulation anomalies connecting the temperature and precipitation dipoles are consistent across various timescales.The frequencies of daily events with opposite phases of the temperature dipole modulate the interannual and interdecadal variability in precipitation.The south drying and north wetting pattern over the Tibetan Plateau is an interdecadal manifestation of the precipitation dipole and can be ascribed to the temperature trend favourable for the positive phase of the zonal temperature dipole.The consistent dipole pattern constructs a more complete portrayal of precipitation over the Tibetan Plateau from synoptic scale to climatology.
文摘BACKGROUND Myasthenia gravis(MG)is an autoimmune disorder caused by neuromuscular junction failure characterized by muscle weakness and fatigability.We herein report a case of MG that received intravascular laser irradiation of blood(ILIB)interventions and regained muscle power and better quality of life.To our knowledge,no previous study has investigated the benefits of ILIB treatment on patients with MG.We also evaluated the changes in brain perfusion scan and the MG activities of daily living(MG-ADL)and quantitative MG(QMG)scales.CASE SUMMARY A 59-year-old man presented to our outpatient hospital experiencing ptosis,diplopia,fibromyalgia,muscle fatigue,and fluctuating weakness in his limbs for 1 year.Based on his history,physical examination,and laboratory investigations,the final diagnosis was a flare-up of MG with poor endurance and muscle fatigue.The patient agreed to receive ILIB.Brain single-photon emission computed tomography(SPECT)was performed both before and after ILIB therapy.After receiving three courses of ILIB,the brain SPECT images showed greatly increased perfusion of the frontal lobe and anterior cingulate gyri.The patient’s MG-ADL scale score decreased markedly from 17/24 to 3/24.The QMG scale score also decreased remarkably from 32/39 to 9/39.The symptoms of MG became barely detectable and the patient was able to perform his activities of daily living and regain muscle power.CONCLUSION ILIB might have beneficial effects on MG,and brain SPECT images provided direct evidence of a positive correlation between ILIB and clinical performance.
