With the rise of various new reading media and the rapid development of the digitization of paper resources,the traditional function positioning of university libraries based on information query is facing unprecedent...With the rise of various new reading media and the rapid development of the digitization of paper resources,the traditional function positioning of university libraries based on information query is facing unprecedented challenges.How to deal with the change of social information?The library should be demand-oriented,re-examine its own value and find a new starting point.With the help of the concept of customer delivered value and based on 4P theory,this paper constructs the value chain of university library from the dimensions of product,image,personnel and service,and forms a multi-dimensional development positioning system.展开更多
BACKGROUND: The development of a harmless and effi- cient nonviral gene delivery system that can facilitate the penetration of nucleic acids through the plasma membrane is a key to successful gene therapy. The aim of ...BACKGROUND: The development of a harmless and effi- cient nonviral gene delivery system that can facilitate the penetration of nucleic acids through the plasma membrane is a key to successful gene therapy. The aim of this study was to test a nonviral gene transferring vector’s function of delivering DNA into liver cells to provide an important clue for gene transfer in liver gene therapy. METHODS: The complex of DNA and DNA delivering protein was injected into mice through their tail veins. Then the mice were killed and their liver tissue was sec- tioned. The gene transferring results were detected using a confocal laser scanning microscope. RESULTS: Fluorescence analysis indicated that both DNA- membrane penetrating peptide (MPP) complex and DNA- hepatocyte specific receptor binding domain ( HSRBD) - MPP complex could go into liver cells. The fluorescence value of liver cells in the DNA-HSRBD-MPP group was higher than that in the DNA-MPP group. CONCLUSIONS; MPP can successfully deliver DNA and protein into cells, and MPP with a HSRBD can specifically deliver DNA into liver cells. These have laid a foundation for further study on the nonviral liver cell gene delivering system.展开更多
The development of novel drug delivery systems is an essential step toward controlled site-specific administration of therapeutics within the body. It is desirable for delivery vehicles to be introduced into the body ...The development of novel drug delivery systems is an essential step toward controlled site-specific administration of therapeutics within the body. It is desirable for delivery vehicles to be introduced into the body through minimally invasive means and, these vehicles should be capable of releasing drug to their intended location at a controlled rate. Furthermore, it is desirable to develop drug delivery systems that are capable of in vivo to suffer degradation and to deliver the drug completely, avoiding the need to surgically remove the vehicle at the end of its useful lifetime. Hydrogels are of particular interest for drug delivery applications due to their ability to address these needs in addition to their good biocompatibility, tunable network structure to control the diffusion of drugs and, tunable affinity for drugs. However, hydrogels are also limited for drug delivery applications due to the often quick elution of drug from their highly swollen polymer matrices as well as the difficulty inherent in the injection of macroscopic hydrogels into the body. This paper presents an overview to the advances in hydrogels based drug delivery. Different types of hydrogels can be used for drug delivery to specific sites in the gastrointestinal tract ranging from the oral cavity to the colon. These novel systems exhibit a range of several peculiar properties which make them attractive as controlled drug release formulations. Moreover, such materials are biocompatible and can be formulated to give controlled, pulsed, and triggered drug release profiles in a variety of tissues.展开更多
Over the past few years,different neurontargeted nanoparticles(NPs)were designed to deliver drugs to enhance neuron protection and recovery,and much progress was made in our understanding of the uptake mechanism and t...Over the past few years,different neurontargeted nanoparticles(NPs)were designed to deliver drugs to enhance neuron protection and recovery,and much progress was made in our understanding of the uptake mechanism and the related physicochemical properties.Physicochemical properties attracting much attentions in NP's design and modification include particle size,surface hydrophobicity。展开更多
Exchange rate functions under systems of centrallyplanned economy and market economy are quite different,and the mechanism to determine such exchange rate is alsodifferent. To adopt a socialist market economic system ...Exchange rate functions under systems of centrallyplanned economy and market economy are quite different,and the mechanism to determine such exchange rate is alsodifferent. To adopt a socialist market economic system inChina, the exchange rate mechanism of Renminbi must bethoroughly transformed. To accomplish this goal, I believethere are three problems that must be solved: first,展开更多
ZTE Corporation,a leading global provider of telecommunications equipment and network solutions,announced on June 6,2007 that it has signed a strategic cooperation agreement with Polkomtel S.A.,one of the top three mo...ZTE Corporation,a leading global provider of telecommunications equipment and network solutions,announced on June 6,2007 that it has signed a strategic cooperation agreement with Polkomtel S.A.,one of the top three mobile telephony operators in Poland.展开更多
At ITU Telecom Africa 2004,Telecom Egyptofficially announced that it had selected ZTECorporation,the leading telecom solutionsprovider in the world,to be its global strategicpartner,and that ZTE would undertake thecon...At ITU Telecom Africa 2004,Telecom Egyptofficially announced that it had selected ZTECorporation,the leading telecom solutionsprovider in the world,to be its global strategicpartner,and that ZTE would undertake theconstruction of its CDMA WLL network anddeliver full services to Telecom Egypt.Akil Beshir,Chairman of展开更多
<strong>Background: </strong>Simple Unicameral and Aneurysmal Bone Cysts are benign lesions that may heal spontaneously especially after fracture which may be the first symptom. However, often size increas...<strong>Background: </strong>Simple Unicameral and Aneurysmal Bone Cysts are benign lesions that may heal spontaneously especially after fracture which may be the first symptom. However, often size increases causing pain, and complications of fractures can severely compromise the patient.<strong> Aim:</strong> The results in a series of cases treated minimally invasive using a new device for the application of allogenic bone material appear highly promising and shall be presented. <strong>Patients and Methods:</strong> Eight consecutive patients with symptomatic Unicameral Bone Cysts (UBC) were treated by percutaneous instillation of Grafton<span style="white-space:nowrap;">?</span> DBF Putty (demineralised allogenic bone containing fibers) mixed with autologous bone marrow using the Kyphon<span style="white-space:nowrap;">?</span> Cement Delivery System (Medtronic), which allows the injection of this high viscosity paste by controlled high pressure. Five patients with Aneurysmal Bone Cysts (ABC) were treated accordingly after inactivation by Aethoxysclerol 3% and lacking bone formation. Using this approach a high rate of bone regeneration was observed in these patients at 8 months to 5 years follow-up (f/u). <strong>Conclusion:</strong> The presented technique of a minimally invasive biologic treatment led to highly satisfying results using the Grafton<span style="white-space:nowrap;">?</span> DBF Putty with its higher potential for bone regeneration than demineralized bone matrix not containing fibres (DBM).展开更多
On September 25,the on-orbit delivery ceremony for China’s new generation geostationary meteorological satellite FY-4 was held in Beijing.China Aerospace Science and Technology Corporation(CASC),the manufacturer of t...On September 25,the on-orbit delivery ceremony for China’s new generation geostationary meteorological satellite FY-4 was held in Beijing.China Aerospace Science and Technology Corporation(CASC),the manufacturer of the satellite officially delivered FY-4 to the customer,the China Meteorological Administration(CMA)for operation.The delivery of FY-4 marks the up-展开更多
The manufacturer of the FY-2G meteorological satellite delivered the satellite to its customer CMA at an in-orbit delivery ceremony held on April 29 in Beijing.The FY-2G meteorological satellite developed by the Shang...The manufacturer of the FY-2G meteorological satellite delivered the satellite to its customer CMA at an in-orbit delivery ceremony held on April 29 in Beijing.The FY-2G meteorological satellite developed by the Shanghai Academy of Spaceflight Technology(SAST),is the second satellite in the third batch of FY-2geostationary meteorological satellite program and was launched on Decem-展开更多
Textiles and apparel might be a global industry,but the latest statistics show trade patterns remain largely regional.However,changes are happening,and align closely with the shifting sourcing strategies of fashion br...Textiles and apparel might be a global industry,but the latest statistics show trade patterns remain largely regional.However,changes are happening,and align closely with the shifting sourcing strategies of fashion brands and retailers and related free trade agreements-as shown in this new analysis by Dr Sheng Lu,associate professor in Fashion and Apparel Studies at the University of Delaware.展开更多
This is my second visit to Los Angeles as the Director of the State Administration for Religious Affairs to exchange views with all the American Christian friends present. I believe what you want to learn best is the ...This is my second visit to Los Angeles as the Director of the State Administration for Religious Affairs to exchange views with all the American Christian friends present. I believe what you want to learn best is the real situation of Chinese Christianity at present. I can tell you with pleasure that Chinese Christians are running their church independently and has thus removed the "cap" of "foreigness". It has become a religion that eulogizes love and traditional culture. As a reli-展开更多
Further evidence of the fast-moving global trend towards total control of yarn quality comes with the news that Uster Technologies has now delivered 1.5 million of its USTER QUANTUM yarn clearers.
China’s next-generation geostationary meteorological satellite FY-4 obtained the first images and data on February 9 and20 after two-months of in-orbit commissioning.The first FY-4satellite was developed by SAST and ...China’s next-generation geostationary meteorological satellite FY-4 obtained the first images and data on February 9 and20 after two-months of in-orbit commissioning.The first FY-4satellite was developed by SAST and was launched into space atop a LM-3B launch vehicle on December 11,2016 and positioned at 99.5°E over the equator on December 17.The satellite,designated as FY-4A officially,carries payloads展开更多
OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradablepolymers prolongs survival against experi-mental brain tumors.Moreover,paracrine administration of interleukin-2(IL-2)has been shown to elicit apotent anti...OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradablepolymers prolongs survival against experi-mental brain tumors.Moreover,paracrine administration of interleukin-2(IL-2)has been shown to elicit apotent antitumor immune response and to improve survival in animal brain tumor models.We report the use of anovel polymeric microsphere delivery vehicle to release IL-2.We demonstrate both in vitro release of cytokinefrom the microspheres and histological evidence of the inflammatory response elicited by IL-2 released from themicrospheres in the rat brain.Thees microspheres are used to deliver IL-2,and biodegradable polymer wafers展开更多
The ChinaSat-10 satellite was delivered to the customer, China Satellite Communicaitons Co. Ltd. on June 28 by CAST. President of CASC, Mr. Ma Xingrui and related leaders of the two parties attended the delivery cerem...The ChinaSat-10 satellite was delivered to the customer, China Satellite Communicaitons Co. Ltd. on June 28 by CAST. President of CASC, Mr. Ma Xingrui and related leaders of the two parties attended the delivery ceremony. The satellite was launched in June, 2011 onboard a LM-3B launch vehicle from the XSLC. It is a geosynchronous satellite展开更多
基金Supported by Key Research Project of Education and Teaching Reform in Beijing University of Agriculture from 2021 to 2022.
文摘With the rise of various new reading media and the rapid development of the digitization of paper resources,the traditional function positioning of university libraries based on information query is facing unprecedented challenges.How to deal with the change of social information?The library should be demand-oriented,re-examine its own value and find a new starting point.With the help of the concept of customer delivered value and based on 4P theory,this paper constructs the value chain of university library from the dimensions of product,image,personnel and service,and forms a multi-dimensional development positioning system.
基金This study was supported by grants from the National Natural Science Foun-dation of China( No:30472251 )and the Shanxi Youth Science Fund ( No.020011028).
文摘BACKGROUND: The development of a harmless and effi- cient nonviral gene delivery system that can facilitate the penetration of nucleic acids through the plasma membrane is a key to successful gene therapy. The aim of this study was to test a nonviral gene transferring vector’s function of delivering DNA into liver cells to provide an important clue for gene transfer in liver gene therapy. METHODS: The complex of DNA and DNA delivering protein was injected into mice through their tail veins. Then the mice were killed and their liver tissue was sec- tioned. The gene transferring results were detected using a confocal laser scanning microscope. RESULTS: Fluorescence analysis indicated that both DNA- membrane penetrating peptide (MPP) complex and DNA- hepatocyte specific receptor binding domain ( HSRBD) - MPP complex could go into liver cells. The fluorescence value of liver cells in the DNA-HSRBD-MPP group was higher than that in the DNA-MPP group. CONCLUSIONS; MPP can successfully deliver DNA and protein into cells, and MPP with a HSRBD can specifically deliver DNA into liver cells. These have laid a foundation for further study on the nonviral liver cell gene delivering system.
基金This work was financially supported by a Grant(Praxis SFRH/BD/48324/2008)from FCT(Fundacao para a Ciencia e a Tecnologia,Portugal).
文摘The development of novel drug delivery systems is an essential step toward controlled site-specific administration of therapeutics within the body. It is desirable for delivery vehicles to be introduced into the body through minimally invasive means and, these vehicles should be capable of releasing drug to their intended location at a controlled rate. Furthermore, it is desirable to develop drug delivery systems that are capable of in vivo to suffer degradation and to deliver the drug completely, avoiding the need to surgically remove the vehicle at the end of its useful lifetime. Hydrogels are of particular interest for drug delivery applications due to their ability to address these needs in addition to their good biocompatibility, tunable network structure to control the diffusion of drugs and, tunable affinity for drugs. However, hydrogels are also limited for drug delivery applications due to the often quick elution of drug from their highly swollen polymer matrices as well as the difficulty inherent in the injection of macroscopic hydrogels into the body. This paper presents an overview to the advances in hydrogels based drug delivery. Different types of hydrogels can be used for drug delivery to specific sites in the gastrointestinal tract ranging from the oral cavity to the colon. These novel systems exhibit a range of several peculiar properties which make them attractive as controlled drug release formulations. Moreover, such materials are biocompatible and can be formulated to give controlled, pulsed, and triggered drug release profiles in a variety of tissues.
基金The project“Nanoparticle Functionalization for Blood-Brain Barrier Passage”was funded by German Research Foundation(SA433/28-1)China Scholarship Council(201406370149)。
文摘Over the past few years,different neurontargeted nanoparticles(NPs)were designed to deliver drugs to enhance neuron protection and recovery,and much progress was made in our understanding of the uptake mechanism and the related physicochemical properties.Physicochemical properties attracting much attentions in NP's design and modification include particle size,surface hydrophobicity。
文摘Exchange rate functions under systems of centrallyplanned economy and market economy are quite different,and the mechanism to determine such exchange rate is alsodifferent. To adopt a socialist market economic system inChina, the exchange rate mechanism of Renminbi must bethoroughly transformed. To accomplish this goal, I believethere are three problems that must be solved: first,
文摘ZTE Corporation,a leading global provider of telecommunications equipment and network solutions,announced on June 6,2007 that it has signed a strategic cooperation agreement with Polkomtel S.A.,one of the top three mobile telephony operators in Poland.
文摘At ITU Telecom Africa 2004,Telecom Egyptofficially announced that it had selected ZTECorporation,the leading telecom solutionsprovider in the world,to be its global strategicpartner,and that ZTE would undertake theconstruction of its CDMA WLL network anddeliver full services to Telecom Egypt.Akil Beshir,Chairman of
文摘<strong>Background: </strong>Simple Unicameral and Aneurysmal Bone Cysts are benign lesions that may heal spontaneously especially after fracture which may be the first symptom. However, often size increases causing pain, and complications of fractures can severely compromise the patient.<strong> Aim:</strong> The results in a series of cases treated minimally invasive using a new device for the application of allogenic bone material appear highly promising and shall be presented. <strong>Patients and Methods:</strong> Eight consecutive patients with symptomatic Unicameral Bone Cysts (UBC) were treated by percutaneous instillation of Grafton<span style="white-space:nowrap;">?</span> DBF Putty (demineralised allogenic bone containing fibers) mixed with autologous bone marrow using the Kyphon<span style="white-space:nowrap;">?</span> Cement Delivery System (Medtronic), which allows the injection of this high viscosity paste by controlled high pressure. Five patients with Aneurysmal Bone Cysts (ABC) were treated accordingly after inactivation by Aethoxysclerol 3% and lacking bone formation. Using this approach a high rate of bone regeneration was observed in these patients at 8 months to 5 years follow-up (f/u). <strong>Conclusion:</strong> The presented technique of a minimally invasive biologic treatment led to highly satisfying results using the Grafton<span style="white-space:nowrap;">?</span> DBF Putty with its higher potential for bone regeneration than demineralized bone matrix not containing fibres (DBM).
文摘On September 25,the on-orbit delivery ceremony for China’s new generation geostationary meteorological satellite FY-4 was held in Beijing.China Aerospace Science and Technology Corporation(CASC),the manufacturer of the satellite officially delivered FY-4 to the customer,the China Meteorological Administration(CMA)for operation.The delivery of FY-4 marks the up-
文摘The manufacturer of the FY-2G meteorological satellite delivered the satellite to its customer CMA at an in-orbit delivery ceremony held on April 29 in Beijing.The FY-2G meteorological satellite developed by the Shanghai Academy of Spaceflight Technology(SAST),is the second satellite in the third batch of FY-2geostationary meteorological satellite program and was launched on Decem-
文摘Textiles and apparel might be a global industry,but the latest statistics show trade patterns remain largely regional.However,changes are happening,and align closely with the shifting sourcing strategies of fashion brands and retailers and related free trade agreements-as shown in this new analysis by Dr Sheng Lu,associate professor in Fashion and Apparel Studies at the University of Delaware.
文摘This is my second visit to Los Angeles as the Director of the State Administration for Religious Affairs to exchange views with all the American Christian friends present. I believe what you want to learn best is the real situation of Chinese Christianity at present. I can tell you with pleasure that Chinese Christians are running their church independently and has thus removed the "cap" of "foreigness". It has become a religion that eulogizes love and traditional culture. As a reli-
文摘Further evidence of the fast-moving global trend towards total control of yarn quality comes with the news that Uster Technologies has now delivered 1.5 million of its USTER QUANTUM yarn clearers.
文摘China’s next-generation geostationary meteorological satellite FY-4 obtained the first images and data on February 9 and20 after two-months of in-orbit commissioning.The first FY-4satellite was developed by SAST and was launched into space atop a LM-3B launch vehicle on December 11,2016 and positioned at 99.5°E over the equator on December 17.The satellite,designated as FY-4A officially,carries payloads
文摘OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradablepolymers prolongs survival against experi-mental brain tumors.Moreover,paracrine administration of interleukin-2(IL-2)has been shown to elicit apotent antitumor immune response and to improve survival in animal brain tumor models.We report the use of anovel polymeric microsphere delivery vehicle to release IL-2.We demonstrate both in vitro release of cytokinefrom the microspheres and histological evidence of the inflammatory response elicited by IL-2 released from themicrospheres in the rat brain.Thees microspheres are used to deliver IL-2,and biodegradable polymer wafers
文摘The ChinaSat-10 satellite was delivered to the customer, China Satellite Communicaitons Co. Ltd. on June 28 by CAST. President of CASC, Mr. Ma Xingrui and related leaders of the two parties attended the delivery ceremony. The satellite was launched in June, 2011 onboard a LM-3B launch vehicle from the XSLC. It is a geosynchronous satellite
