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Design study of APS-U-type hybrid-MBA lattice for mid-energy DLSR 被引量:1
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作者 Yu Zhao Yi Jiao Sheng Wang 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2021年第7期46-54,共9页
In recent years,a new generation of storage ring-based light sources,known as diffraction-limited storage rings(DLSRs),whose emittance approaches the diffraction limit for the range of X-ray wavelengths of interest to... In recent years,a new generation of storage ring-based light sources,known as diffraction-limited storage rings(DLSRs),whose emittance approaches the diffraction limit for the range of X-ray wavelengths of interest to the scientific community,has garnered significant attention worldwide.Researchers have begun to design and build DLSRs.Among various DLSR proposals,the hybrid multibend achromat(H-MBA)lattice enables sextupole strengths to be maintained at a reasonable level when minimizing the emittance;hence,it has been adopted in many DLSR designs.Based on the H-7BA lattice,the design of the Advanced Photon Source Upgrade Project(APS-U)can effectively reduce emittance by replacing six quadrupoles with anti-bends.Herein,we discuss the feasibility of designing an APS-U-type H-MBA lattice for the Southern Advanced Photon Source,a mid-energy DLSR light source with ultralow emittance that has been proposed to be built adjacent to the China Spallation Neutron Source.Both linear and nonlinear dynamics are optimized to obtain a detailed design of this type of lattice.The emittance is minimized,while a sufficiently large dynamic aperture(DA)and momentum acceptance(MA)are maintained.A design comprising 36 APS-U type H-7BAs,with an energy of 3 GeV and a circumference of 972 m,is achieved.The horizontal natural emittance is 20 pm·rad,with a horizontal DA of 5.8 mm,a vertical DA of 4.5 mm,and an MA of 4%,as well as a long longitudinal damping time of 120 ms.Subsequently,a few modifications are performed based on the APS-U-type lattice to reduce the maximum value of damping time from 120 to 44 ms while maintaining other performance parameters at the same level. 展开更多
关键词 Southern advanced photon source(SAPS) Diffraction-limited storage ring(DLSR) Hybrid multibend achromat(H-MBA) Advanced photon source upgrade project(APS-U) Lattice design
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Collaborating with Young Adults Diagnosed with Schizophrenia:A Participatory Design Study to Shape the Healthcare System
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作者 Malene Terp Charlotte D.Bjornes +2 位作者 Rikke Jorgensen Jan Mainz Birgitte Schantz Laursen 《Open Journal of Nursing》 2017年第7期743-758,共16页
Introduction: Disengagement from mental health services in young adults with schizophrenia has been associated with dissatisfaction and unmet needs. Striving to improve engagement, we invited service users recently di... Introduction: Disengagement from mental health services in young adults with schizophrenia has been associated with dissatisfaction and unmet needs. Striving to improve engagement, we invited service users recently diagnosed with schizophrenia to be co-designers of a smartphone technology that will be responsive to their needs. Aim: This paper reports the first phase of a three-phased participatory design process. The objective was to identify needs of support in young adults recently diagnosed with schizophrenia and to generate ideas of how the needs could be accommodated using smartphone technology. Methods: Participatory design guided the research process and a qualitative approach was used to generate and analyse the data. Data were generated by means of participant observations (n = 45 hours) and interviews (n = 6) with young adults from a first episode psychosis program in Denmark. Findings: Low levels of knowledge and high levels of uncertainties are characteristic of young adults recently diagnosed with schizophrenia, bringing about a vast need of support in order for them to gain power over their new life situation. Our study suggests that the smartphone may be used to foster empowerment by guiding the young adult’s actions in situ, providing comprehensive and easily understood information on the go, allowing for recovery tracking, and notification of mental health changes, providing medication overview and giving easy access to healthcare providers. Conclusion: Young adults recently diagnosed with schizophrenia require comprehensive support in order to become empowered to confidently manage their new life situation. The smartphone holds this potential by offering flexible collaboration and timely access to self-management 展开更多
关键词 EMPOWERMENT Mobile Health Participatory design SCHIZOPHRENIA Young adults
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Optimal design study of high order FIR digital filters based on neural network algorithm 被引量:2
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作者 Wang Xiaohua & He YigangCollege of Electrical and Information Engineering, Hunan University, Changsha 410082, P. R. China College of Electrical and Information Engineering, Changsha University of Science and Technology,Changsha 410077, P. R. China 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2004年第2期115-119,130,共6页
An optimal design approach of high order FIR digital filter is developed based on the algorithm of neural networks with cosine basis function . The main idea is to minimize the sum of the square errors between the amp... An optimal design approach of high order FIR digital filter is developed based on the algorithm of neural networks with cosine basis function . The main idea is to minimize the sum of the square errors between the amplitude response of the desired FIR filter and that of the designed by training the weights of neural networks, then obtains the impulse response of FIR digital filter . The convergence theorem of the neural networks algorithm is presented and proved, and the optimal design method is introduced by designing four kinds of FIR digital filters , i.e., low-pass, high-pass, bandpass , and band-stop FIR digital filter. The results of the amplitude responses show that attenuation in stop-bands is more than 60 dB with no ripple and pulse existing in pass-bands, and cutoff frequency of passband and stop-band is easily controlled precisely . The presented optimal design approach of high order FIR digital filter is significantly effective. 展开更多
关键词 神经网络 FIR数字滤波 幅度频率响应 收敛定理
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Curriculum Ideological and Political Teaching and Practice of Study Tour Course Design in Higher Vocational Colleges: A Case Study of Qingdao Preschool Education College
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作者 YANG Qiong LI Yanan 《Journal of Landscape Research》 2024年第1期86-90,共5页
Curriculum ideology and politics are critical for colleges and universities to fulfill theirfundamental mission of fostering moral and intellectual development. Within this framework, professionalcourses serve as the ... Curriculum ideology and politics are critical for colleges and universities to fulfill theirfundamental mission of fostering moral and intellectual development. Within this framework, professionalcourses serve as the primary vehicles for integrating ideological and political education. Specifically, inthe field of study tours, the Study Tour Course Design emerges as a pivotal component for actualizingthe educational objectives of such programs. To construct a robust ideological and political curriculum,it is essential to devise a comprehensive system that aligns with professional teaching standards, industrybenchmarks, and vocational skill requirements. This involves a thorough exploration of ideologicaland political elements within the curriculum, ensuring their seamless integration throughout the coursedevelopment process. 展开更多
关键词 study tour course design Curriculum ideology and politics Curriculum construction
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A Comparative Study of Metaheuristic Optimization Algorithms for Solving Real-World Engineering Design Problems
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作者 Elif Varol Altay Osman Altay Yusuf Ovik 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第4期1039-1094,共56页
Real-world engineering design problems with complex objective functions under some constraints are relatively difficult problems to solve.Such design problems are widely experienced in many engineering fields,such as ... Real-world engineering design problems with complex objective functions under some constraints are relatively difficult problems to solve.Such design problems are widely experienced in many engineering fields,such as industry,automotive,construction,machinery,and interdisciplinary research.However,there are established optimization techniques that have shown effectiveness in addressing these types of issues.This research paper gives a comparative study of the implementation of seventeen new metaheuristic methods in order to optimize twelve distinct engineering design issues.The algorithms used in the study are listed as:transient search optimization(TSO),equilibrium optimizer(EO),grey wolf optimizer(GWO),moth-flame optimization(MFO),whale optimization algorithm(WOA),slimemould algorithm(SMA),harris hawks optimization(HHO),chimp optimization algorithm(COA),coot optimization algorithm(COOT),multi-verse optimization(MVO),arithmetic optimization algorithm(AOA),aquila optimizer(AO),sine cosine algorithm(SCA),smell agent optimization(SAO),and seagull optimization algorithm(SOA),pelican optimization algorithm(POA),and coati optimization algorithm(CA).As far as we know,there is no comparative analysis of recent and popular methods against the concrete conditions of real-world engineering problems.Hence,a remarkable research guideline is presented in the study for researchersworking in the fields of engineering and artificial intelligence,especiallywhen applying the optimization methods that have emerged recently.Future research can rely on this work for a literature search on comparisons of metaheuristic optimization methods in real-world problems under similar conditions. 展开更多
关键词 Metaheuristic optimization algorithms real-world engineering design problems multidisciplinary design optimization problems
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Theoretical Research and Practical Application of the Rural Cultural Enhancement by Creative Designs Under Rural Vitalization-A Case Study of Shanxi Province
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作者 BAI Lu 《Journal of Literature and Art Studies》 2024年第2期155-164,共10页
To revive the nation,the rural area must be revitalized.Every regional cultural and creative industry has its own development path and practical mode.From the perspective of rural revitalization,this paper conducts re... To revive the nation,the rural area must be revitalized.Every regional cultural and creative industry has its own development path and practical mode.From the perspective of rural revitalization,this paper conducts research on the development model of cultural and creative design,and analyzes the significance of the integration of creative design with rural regional culture.Based on the current situation of rural cultural and creative development in Shanxi Province,this study proposes to form a brand communication chain through the integration between cultural design and rural culture,and the establishment of cultural and creative brands,furthermore,to establish trending topics through multiple channels.Finally,the important practical significance of cultural and creative design in promoting rural economic development and enhancing rural culture value is discussed in this design strategy,so as to actively help the new journey of rural revitalization. 展开更多
关键词 rural vitalization creative designs rural culture SHANXI
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Landscape Architecture Planning and Design Based on Landscape Ecology Theory:A Case Study of Waterfront Landscape Planning and Design of Dapo Town
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作者 WANG Sangju XIAO Shizhen 《Journal of Landscape Research》 2024年第1期35-39,42,共6页
With the rapid development of urbanization,landscape architecture has become an indispensable component of daily life.In order to achieve better landscape effects and protect the ecological environment,landscape ecolo... With the rapid development of urbanization,landscape architecture has become an indispensable component of daily life.In order to achieve better landscape effects and protect the ecological environment,landscape ecology theory can be integrated into landscape planning to carry out disciplinary crossing and integration research between landscape ecology and landscape architecture.In this study,based on the basic theories of landscape ecology,the waterfront landscape of Dapo Town was designed,with the aim to achieve ecological balance in planning,showcase biodiversity,and create a harmonious landscape ecological environment which can benefit both nature and people.This design combined artificial and natural elements while improving the natural environment,which promoted a harmonious relationship between humans and nature,thus enriching the spatial organization of the city,and playing a role in regulating the urban environment and climate. 展开更多
关键词 Landscape ecology theory Landscape architecture planning and design Dapo Town Waterfront landscape
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Factorial Experimental Design to Study the Effects of Layers and Fiber Content on Concrete Flexural Behavior
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作者 Dumbiri H. Odia 《Open Journal of Civil Engineering》 CAS 2023年第1期83-102,共20页
Experimentation has come a long in helping researchers achieve breakthroughs in their different scientific areas and engineering happens to be one of those areas with the most impact from experimental advancement. The... Experimentation has come a long in helping researchers achieve breakthroughs in their different scientific areas and engineering happens to be one of those areas with the most impact from experimental advancement. The need for valid experimental results free from biases and confounding conclusions has prompted the development of new experimental techniques that takes consideration of all applicable factor and combinations in providing answers on a research topic, and the Factorial Experimental design credited to Sir Ronald Fisher is one technique yielding highly valid results. This paper uses the factorial design of experiments to research the flexural impact of polyvinyl acetate fiber and layered concrete in construction. The experiment considered two levels of fiber contents and two levels of layers, and prepared samples with all combinations of the variable factors. The samples were tested after 7 days from casting for flexural strength and an advance statistical analysis was performed on the flexural responses of the samples using R-program. The results from the analyses revealed the significance of the variables to the flexural strength of the samples, as well as their interactions. The experiment concluded that based on the number of layers and fiber content used for the experiment, casting concrete in layers does have a significant negative effect on the flexural strength of concrete, and the failure pattern of concrete members under flexural load in evidently influenced by the material composition of the concrete, and that it can be evidently influenced by casting the concrete in layers. 展开更多
关键词 Experimental design Concrete Flexural Strength Factorial design of Experiments Concrete Fibers Concrete Layers
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Practice and Exploration of Experiential Theme Landscape Design in Urban Historic Blocks: A Case Study of Shengjin Tower Folk Custom Historical Block in Nanchang
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作者 FANG Qianghua FANG Huan XI Xingzhou 《Journal of Landscape Research》 2023年第6期35-42,46,共9页
Urban historic blocks are an important part of urban public space,but urban public space pays far less attention to users’experience,and there is a lack of design problem of experiential theme landscape.The landscape... Urban historic blocks are an important part of urban public space,but urban public space pays far less attention to users’experience,and there is a lack of design problem of experiential theme landscape.The landscape design practice of Shengjin Tower Folk Custom Historical Block in Nanchang provides an attempt to explore the design problem of experiential theme landscape.In this paper,the results of the design practice were sorted out and summarized,and the specific conception of the experiential design of urban public space was discussed from three aspects of the experiential control design,spatial experience design and serial experience design of the historic block on the basis of elaborating the design concept,so as to provide inspiration and reference for similar urban historic block projects. 展开更多
关键词 Experiential design Historic block LANDSCAPE design practice
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Influence of Urban Street Greening Design under the Concept of Green Healthy Cities:A Case Study of Hefei City
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作者 HUANG Jin 《Journal of Landscape Research》 2023年第4期31-34,40,共5页
In order to explore the influence of urban street greening,the street landscape of Changjiang West Road and Xiyou Road in Hefei City was selected as the research sample to study the design of urban street landscape un... In order to explore the influence of urban street greening,the street landscape of Changjiang West Road and Xiyou Road in Hefei City was selected as the research sample to study the design of urban street landscape under the concept of green healthy cities.The results show that the urban street landscape of Hefei City is single in design and plant type,and plant maintenance management is not good.It is proposed to strengthen the maintenance and management of street greening,increase the types of native plants,and improve cultural connotation,so as to enhance the artistry,regionalism and functionality of urban street landscape in Hefei City. 展开更多
关键词 Green healthy cities Urban landscape design Street landscape design
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Planning and Design of Beautiful Countryside Based on the Concept of Stormwater Resilience: A Case Study of Shanbei Village, Yunfu City, Guangdong Province
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作者 ZHONG Guoqing 《Journal of Landscape Research》 2023年第6期13-19,共7页
Shanbei Village is a village in Yunfu of Guangdong,which has been seriously affected by flood disasters.In the context of the construction of beautiful countryside,utilizing the concept of resilience stormwater,constr... Shanbei Village is a village in Yunfu of Guangdong,which has been seriously affected by flood disasters.In the context of the construction of beautiful countryside,utilizing the concept of resilience stormwater,construction ideas of beautiful countryside of combining the prevention and control of village flood disasters with economic and social development and cultural heritage are proposed.The planning methods of adjusting the planting way of crops,demolition of dwellings in submerged areas and development and utilization of ancient dwellings,sorting out drainage systems and planning“large,medium and small sponges”,and improving the drainage capacity of culverts are summarized. 展开更多
关键词 Stormwater resilience Beautiful countryside Planning and design
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Planning and Design of Geological Landscape Popular Science Exhibition in Urban Geopark:A Case Study of Zhengzhou Yellow River National Geopark
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作者 YANG Dongjiang TANG Chang 《Journal of Landscape Research》 2023年第4期6-8,16,共4页
Urban geopark is the backyard garden of urban residents’life.Geological landscape popular science exhibition enables people to receive geological popular science knowledge easily and happily while playing,which will ... Urban geopark is the backyard garden of urban residents’life.Geological landscape popular science exhibition enables people to receive geological popular science knowledge easily and happily while playing,which will virtually strengthen people’s protection awareness of urban geological landscape.Urban geopark landscape is featured by unique typical geological characteristics.It is a realistic problem that troubles the planning and design of geological landscape popular science exhibition in urban geopark by effectively protecting these geological landscapes and upgrading them into urban popular science leisure tourism resources.Taking Zhengzhou Yellow River National Geopark as an example,this paper systematically studies the planning and design of geological landscape popular science exhibition in urban geopark. 展开更多
关键词 Urban geopark Geological landscape Popular science exhibition Planning and design
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基于“Design Thinking”理念的职业院校创新创业人才培养模式
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作者 杨经纬 《产业创新研究》 2024年第7期184-186,共3页
随着我国经济不断发展和社会进步,创新创业已经成为推动经济增长的关键驱动力,在2015年全国人民代表大会上,李克强总理将“大众创业、万众创新”明确列为我国经济增长的“双引擎”之一,彰显了创新创业对于推动社会发展的重要地位。为响... 随着我国经济不断发展和社会进步,创新创业已经成为推动经济增长的关键驱动力,在2015年全国人民代表大会上,李克强总理将“大众创业、万众创新”明确列为我国经济增长的“双引擎”之一,彰显了创新创业对于推动社会发展的重要地位。为响应国家政策,各高校积极开展创新创业教育,将其纳入高等教育综合改革的重要议程,成为培养未来人才的重要途径。本文分析了“Design Thinking”理念下职业院校创新创业人才培养的必要性,围绕新时期专业院校创新创业人才培养的要求,提出了基于“Design Thinking”理念的职业院校创新创业人才培养模式的有效策略,为职业院校人才培养效率的强化提供了参考性意见。 展开更多
关键词 design Thinking”理念 职业院校 创新创业 人才培养
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Recent progresses in the development of tubular segmented-in-series solid oxide fuel cells:Experimental and numerical study
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作者 Shuo Han Tao Wei +6 位作者 Sijia Wang Yanlong Zhu Xingtong Guo Liang He Xiongzhuang Li Qing Huang Daifen Chen 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第3期427-442,共16页
Solid oxide fuel cells(SOFCs)have attracted a great deal of interest because they have the highest efficiency without using any noble metal as catalysts among all the fuel cell technologies.However,traditional SOFCs s... Solid oxide fuel cells(SOFCs)have attracted a great deal of interest because they have the highest efficiency without using any noble metal as catalysts among all the fuel cell technologies.However,traditional SOFCs suffer from having a higher volume,current leakage,complex connections,and difficulty in gas sealing.To solve these problems,Rolls-Royce has fabricated a simple design by stacking cells in series on an insulating porous support,resulting in the tubular segmented-in-series solid oxide fuel cells(SIS-SOFCs),which achieved higher output voltage.This work systematically reviews recent advances in the structures,preparation methods,perform-ances,and stability of tubular SIS-SOFCs in experimental and numerical studies.Finally,the challenges and future development of tubular SIS-SOFCs are also discussed.The findings of this work can help guide the direction and inspire innovation of future development in this field. 展开更多
关键词 solid oxide fuel cell SEGMENTED-IN-SERIES TUBULAR experimental study numerical study
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Study on Mechanical Properties of High Fine Silty Basalt Fiber Shotcrete Based on Orthogonal Design
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作者 Jinxing Wang Yingjie Yang +5 位作者 Xiaolin Yang Huazhe Jiao Qi Wang Liuhua Yang Jianxin Yu Fengbin Chen 《Journal of Renewable Materials》 EI 2023年第8期3351-3370,共20页
In order to improve the comprehensive utilization rate of highfines sand(HFS)produced by the mine,full solid waste shotcrete(HFS-BFRS)was prepared with HFS asfine aggregate in cooperation with basaltfiber(BF).The strengt... In order to improve the comprehensive utilization rate of highfines sand(HFS)produced by the mine,full solid waste shotcrete(HFS-BFRS)was prepared with HFS asfine aggregate in cooperation with basaltfiber(BF).The strength growth characteristics of HFS-BFRS were analyzed.And thefitting equation of compressive strength growth characteristics of HFS-BFRS under the synergistic effect of multiple factors was given.And based on the orthogonal experimental method,the effects on the compressive strength,splitting tensile strength andflex-ural strength of HFS-BFRS under the action of different levels of influencing factors were investigated.The effect of three factors on the mechanical properties of HFS-BFRS,3,and 28 d,respectively,was revealed by choosing the colloidal sand ratio(C/H),basaltfiber volume fraction(BF Vol)and naphthalene high-efficiency water reducing agent(FDN)as the design variables,combined with indoor tests and theoretical analysis.The results show that the sensitivity of the three factors on compressive strength andflexural strength is C/H>FDN>BF Vol,and split-ting tensile strength is BF Vol>FDN>C/H.Finally,thefitting ratio of HFS-BFRS was optimized by the factor index method,and the rationality was verified by thefield test.For thefluidity of HFS-BFRS,the slump can be improved by 139%under the action of 1.2%FDN,which guarantees the pump-ability of HFS-BFRS. 展开更多
关键词 Solid wastes recycling high-fine silt basaltfiber total solid waste shotcrete orthogonal design
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The Study of Optimizing Reservoir Model Using Experimental Design in Stochastic Models
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作者 Huan Wang Xiaojun Jiang 《Journal of Civil Engineering and Architecture》 2023年第3期145-151,共7页
In response to the main problems in commonly used model selection methods,a method was proposed to apply the concept of experimental design to the optimization of uncertain reservoir models.Firstly,based on the actual... In response to the main problems in commonly used model selection methods,a method was proposed to apply the concept of experimental design to the optimization of uncertain reservoir models.Firstly,based on the actual situation of the oil field,the uncertain variables were determined that affect the geological reserves of the model and their possible range of variation,and experimental design was used to determine the modeling plan.Then,multiple geological models were established and reserves were calculated,and multiple regression was performed between uncertain variables and the corresponding geological reserves of the model.Finally,Monte Carlo simulation technology was applied to determine the parameters of the P10,P50,and P90 models for probabilistic reserves,and P10,P50,and P90 models were established.This method is not only more objective and time-saving in the application process,but also can determine the main geological variables that affect geological reserves,providing a new idea for evaluating the uncertainty of geological reserves. 展开更多
关键词 Uncertainty evaluation experimental design random modeling model optimization
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Study of the Ballistic Impact Behavior of Protective Multi-Layer Composite Armor
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作者 Dongsheng Jia Yingjie Xu +2 位作者 Liangdi Wang Jihong Zhu Weihong Zhang 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第7期171-199,共29页
The abalone shell,a composite material whose cross-section is composed of inorganic and organic layers,has high strength and toughness.Inspired by the abalone shell,several multi-layer composite plates with different ... The abalone shell,a composite material whose cross-section is composed of inorganic and organic layers,has high strength and toughness.Inspired by the abalone shell,several multi-layer composite plates with different layer sequences and thicknesses are studied as bullet-proof material in this paper.To investigate the ballistic performance of this multi-layer structure,the complete characterization model and related material parameters of large deformation,failure and fracture ofAl_(2)O_(3)ceramics andCarbon Fiber Reinforced Polymer(CFRP)are studied.Then,3D finite element models of the proposed composite plates with different layer sequences and thicknesses impacted by a 12.7 mm armor-piercing incendiary(API)are built using Abaqus to predict failure.The simulation results show that the CFRP/Al2O3 ceramic/Ultrahigh Molecular Weight Polyethylene(UHMWPE)/CFRP(1 mm/4 mm/4 mm/1 mm)composite is the optimized stack of layers.The simulation results under specified layer sequence and thickness have a reasonable correlation with the experimental results and reflect the failure and fracture of the multi-layer composite protective armor. 展开更多
关键词 Protective armor COMPOSITE bionic design structure design mechanical property
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Web Layout Design of Large Cavity Structures Based on Topology Optimization
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作者 Xiaoqiao Yang Jialiang Sun Dongping Jin 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第3期2665-2689,共25页
Large cavity structures are widely employed in aerospace engineering, such as thin-walled cylinders, blades andwings. Enhancing performance of aerial vehicles while reducing manufacturing costs and fuel consumptionhas... Large cavity structures are widely employed in aerospace engineering, such as thin-walled cylinders, blades andwings. Enhancing performance of aerial vehicles while reducing manufacturing costs and fuel consumptionhas become a focal point for contemporary researchers. Therefore, this paper aims to investigate the topologyoptimization of large cavity structures as a means to enhance their performance, safety, and efficiency. By usingthe variable density method, lightweight design is achieved without compromising structural strength. Theoptimization model considers both concentrated and distributed loads, and utilizes techniques like sensitivityfiltering and projection to obtain a robust optimized configuration. The mechanical properties are checked bycomparing the stress distribution and displacement of the unoptimized and optimized structures under the sameload. The results confirm that the optimized structures exhibit improved mechanical properties, thus offering keyinsights for engineering lightweight, high-strength large cavity structures. 展开更多
关键词 Topology optimization lightweight design web layout design cavity structure
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A Study on Emotional Design for Vitamin C Dietary Supplements(Chinese Market,Generation Z Consumers)
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作者 Suimeng Qin Albert Young Choi 《Psychology Research》 2023年第11期527-536,共10页
China,recognized as the world’s largest developing nation,displays considerably lower per capita consumption of dietary supplements in comparison to Asian nations such as Japan and South Korea.However,in recent years... China,recognized as the world’s largest developing nation,displays considerably lower per capita consumption of dietary supplements in comparison to Asian nations such as Japan and South Korea.However,in recent years,there has been a substantial surge in health consciousness among the Chinese populace.This trend is not confined to the middle-aged and elderly;even younger consumer demographics are exhibiting increased health awareness.Consequently,the target demographic for dietary supplements is transitioning towards a younger demographic.Within the Chinese dietary supplement industry,vitamin C has consistently held the largest market share,commanding a broad consumer base.This underscores the substantial role of vitamin C in the dietary supplement sector.In response to the trend towards a younger target demographic in the dietary supplement industry,adjustments are required to accommodate the preferences of this younger consumer group.This research,guided by Norman’s emotional design framework,executed a survey of over 200 respondents to investigate the preferences of Generation Z consumers in China.The research encompassed packaging,product forms,and brand imagery,corresponding to the emotional design’s visceral,behavioral,and reflective layers,with a primary focus on optimally meeting the emotional needs of Generation Z.The findings indicated that consumers favor products in capsule form,packaged in zip-lock.The predominant color scheme is clean white,accented by vibrant orange elements,while emphasizing the product’s health and scientific attributes.This study offers valuable insights for the continued evolution of the vitamin C dietary supplement market in China. 展开更多
关键词 Generation Z consumers vitamin C products emotional design
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Pharmacodynamic Study of Parallel Groups Comparing the Effect of Rivaroxaban 20 Mg (Laboratorios Leti, S.A.V.) vs Rivaroxaban 20 Mg (Bayer Laboratories) on Prothrombin Time
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作者 Elsy Rodriguez de Roa María Gonzalez Yibirin +1 位作者 David Rincón Matute Carolina Aguilera 《International Journal of Clinical Medicine》 CAS 2024年第3期123-133,共11页
Background: The prevalence of both atrial fibrillation (FA) and diabetes mellitus (DM) is increasing and they often occur together and constitute a high risk of thrombosis. Rivaroxaban is a Factor Xa inhibitor with a ... Background: The prevalence of both atrial fibrillation (FA) and diabetes mellitus (DM) is increasing and they often occur together and constitute a high risk of thrombosis. Rivaroxaban is a Factor Xa inhibitor with a rapid onset and disappearance of action after oral administration;it acts by inhibiting the active form of the coagulation factor. In order to reflect the effect of the action of Rivaroxaban, we used the prothrombin time (PT);however, it′s not the most accurate, but it is the one available in our community. Methods: This was a prospective, randomized, analyst-blinded, parallel group clinical study to verify the efficacy of Rivaroxaban Leti 20 mg (RL) (12 volunteers vs Rivaroxaban Bayer 20 mg (RB) (13 volunteers). The variables were determination of PT and Partial Thromboplastin Time (aPTT) at baseline and at 24, 48 and 72 hours after administering a daily dose of 20 mg for three days. The determination was carried out with the IDG method (Integrated Diagnostics Group Sanzay Corporation) with an International Sensitivity Index (ISI) of 1.17 PT and aPTT were taken before the first dose, and then, every day during the next 3 days, three hours after the ingestion of their daily dose at 7 am. Results: The 25 healthy volunteers were similar in age, BMI, and SBP/DBP level with a greater number of men in the Bayer group. The efficacy of rivaroxaban was similar in both groups with prolongation of PTT to the 2nd day of treatment with PT, and percentage changes from baseline (14.46 ± 0.97 for RB vs 14.17 ± 0.94 RL p: 0.45), PTT results and percentage changes from the base (RB: 34 ± 4.53 RL: 33.46 ± 2.82). The safety of rivaroxaban was good in both groups with no serious adverse events. The equivalence in the logarithmically transformed PT result (ln) on day two, Mean and CI (90%) 99.2 (94.4-104) and 100 (99.5-100.8);neither the means nor the 90% confidence intervals of the PT variable transformed logarithmically to ensure its normality, were far from the 80%-125% allowed for declaration of similarity. Conclusion: The test formulation Rivaroxaban Asarap<sup>?</sup> 20 mg, manufactured by Leti Laboratories, is interchangeable or bioequivalent in clinical and laboratory response to the reference formulation Xarelto<sup>?</sup> manufactured by Bayer Laboratories. 展开更多
关键词 Pharmacodynamic study RIVAROXABAN Clinical Trial PT APTT
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