Resonance lines are extensively used to diagnose electronic temperature Te and ions distribution. However, the analysis of the x-ray spectroscopy emitted from plasmas produced by a ns laser Jsually needs the help of a...Resonance lines are extensively used to diagnose electronic temperature Te and ions distribution. However, the analysis of the x-ray spectroscopy emitted from plasmas produced by a ns laser Jsually needs the help of a code or some assumptions. In this paper, a diagnostic idea of using line-pairs emitted from a doubly-excited state is proposed. By using the method presented in this paper, Te and the fractional population ratio of bare nuclei and H-like ions are directly obtained from the emission intensity ratios.展开更多
The Neutralized Drift Compression Experiment-II(NDCX-II)is an induction linac that generates intense pulses of 1.2 MeV helium ions for heating matter to extreme conditions.Here,we present recent results on optimizing ...The Neutralized Drift Compression Experiment-II(NDCX-II)is an induction linac that generates intense pulses of 1.2 MeV helium ions for heating matter to extreme conditions.Here,we present recent results on optimizing beam transport.The NDCX-II beamline includes a 1-m-long drift section downstream of the last transport solenoid,which is filled with charge-neutralizing plasma that enables rapid longitudinal compression of an intense ion beam against space-charge forces.The transport section on NDCX-II consists of 28 solenoids.Finding optimal field settings for a group of solenoids requires knowledge of the envelope parameters of the beam.Imaging the beam on the scintillator gives the radius of the beam,but the envelope angle is not measured directly.We demonstrate how the parameters of the beam envelope(radius,envelop angle,and emittance)can be reconstructed from a series of images taken by varying the B-field strengths of a solenoid upstream of the scintillator.We use this technique to evaluate emittance at several points in the NDCX-II beamline and for optimizing the trajectory of the beam at the entry of the plasma-filled drift section.展开更多
The present study was designed to characterize the chemical constituents of Guge Fengtong Tablet(GGFTT).Based on the chromatographic retention behavior,fragmentation pathways of chemical components and the published l...The present study was designed to characterize the chemical constituents of Guge Fengtong Tablet(GGFTT).Based on the chromatographic retention behavior,fragmentation pathways of chemical components and the published literatures,a diagnostic ion filtering strategy with electrospray ionization quadrupole time-of-flight tandem mass spectrometry(HPLC-ESI-Q-TOF/MS) was established to identify the multiple bioactive constituents of GGFTT.The rapid identification of forty-seven components,including 18 phenolic acids,8 saponins,14 gingerol-related compounds,and 7 diarylhepatonoids,was accomplished using this newly developed method.The coupling of HPLC-ESI-Q-TOF/MS with the diagnostic ion filtering strategy was useful and efficient for the in-depth structural elucidation of chemical compounds of GGFTT.展开更多
The acoustic pulse emitted from the Bragg peak of a laser-accelerated proton bunch focused into water has recently enabled the reconstruction of the bunch energy distribution.By adding three ultrasonic transducers and...The acoustic pulse emitted from the Bragg peak of a laser-accelerated proton bunch focused into water has recently enabled the reconstruction of the bunch energy distribution.By adding three ultrasonic transducers and implementing a fast data analysis of the filtered raw signals,I-BEAT(Ion-Bunch Energy Acoustic Tracing)3D now provides the mean bunch energy and absolute lateral bunch position in real-time and for individual bunches.Relative changes in energy spread and lateral bunch size can also be monitored.Our experiments at DRACO with proton bunch energies between 10 and 30 MeV reveal sub-MeV and sub-mm resolution.In addition to this 3D bunch information,the signal strength correlates also with the absolute bunch particle number.展开更多
Steroid saponins are secondary metabolites with multiple medicinal values that are found in large quantities in natural medicines,especially Vernonia amygdalina,a famous nature medicine for the treatment of tonsilliti...Steroid saponins are secondary metabolites with multiple medicinal values that are found in large quantities in natural medicines,especially Vernonia amygdalina,a famous nature medicine for the treatment of tonsillitis,diabetes,pneumonia.The current study was designed to combine molecular networking(MN)with diagnostic ions for rapid identification ofΔ^(7,9(11))stigmastane-type saponins which were theα-glucosidase inhibitory active substances in V.amygdalina.First,theα-glucosidase inhibitory activities of fiveΔ^(7,9(11))stigmastane-type steroid saponins that were previously isolated were screened,which indicated that theΔ^(7,9(11))stigmastane-type steroid saponin was one of the active constituents responsible for ameliorating diabetes.Furthermore,a strategy was proposed to identify stigmastane-type steroid saponins and verify the plausibility of derived fragmentation pathways by applying MN,MolNetEnhancer and unsupervised substructure annotation(MS2LDA).Based on this strategy,other sevenΔ^(7,9(11))stigmastane-type steroid saponins were identified from this plant.Our research provide scientific evidence for the antidiabetic potential of the steroid saponin-rich extract of V.amygdalina leaf.展开更多
The time-of-flight technique coupled with semiconductor detectors is a powerful instrument to provide real-time characterization of ions accelerated because of laser-matter interactions.Nevertheless,the presence of st...The time-of-flight technique coupled with semiconductor detectors is a powerful instrument to provide real-time characterization of ions accelerated because of laser-matter interactions.Nevertheless,the presence of strong electromagnetic pulses(EMPs)generated during the interactions can severely hinder its employment.For this reason,the diagnostic system must be designed to have high EMP shielding.Here we present a new advanced prototype of detector,developed at ENEA-Centro Ricerche Frascati(Italy),with a large-area(15 mm×15 mm)polycrystalline diamond sensor having 150 μm thickness.The tailored detector design and testing ensure high sensitivity and,thanks to the fast temporal response,high-energy resolution of the reconstructed ion spectrum.The detector was offline calibrated and then successfully tested during an experimental campaign carried out at the PHELIX laser facility(E_(L)~100 J,τ_(L)=750 fs,I_(L)(1-2.5)×10^(19)W/cm^(2))at GSI(Germany).The high rejection to EMP fields was demonstrated and suitable calibrated spectra of the accelerated protons were obtained.展开更多
文摘Resonance lines are extensively used to diagnose electronic temperature Te and ions distribution. However, the analysis of the x-ray spectroscopy emitted from plasmas produced by a ns laser Jsually needs the help of a code or some assumptions. In this paper, a diagnostic idea of using line-pairs emitted from a doubly-excited state is proposed. By using the method presented in this paper, Te and the fractional population ratio of bare nuclei and H-like ions are directly obtained from the emission intensity ratios.
基金This work is supported by the Office of Science of the US DOE under contracts DE-AC0205CH11231,DE-AC52-07NA27344,and DE-AC02-09CH11466.
文摘The Neutralized Drift Compression Experiment-II(NDCX-II)is an induction linac that generates intense pulses of 1.2 MeV helium ions for heating matter to extreme conditions.Here,we present recent results on optimizing beam transport.The NDCX-II beamline includes a 1-m-long drift section downstream of the last transport solenoid,which is filled with charge-neutralizing plasma that enables rapid longitudinal compression of an intense ion beam against space-charge forces.The transport section on NDCX-II consists of 28 solenoids.Finding optimal field settings for a group of solenoids requires knowledge of the envelope parameters of the beam.Imaging the beam on the scintillator gives the radius of the beam,but the envelope angle is not measured directly.We demonstrate how the parameters of the beam envelope(radius,envelop angle,and emittance)can be reconstructed from a series of images taken by varying the B-field strengths of a solenoid upstream of the scintillator.We use this technique to evaluate emittance at several points in the NDCX-II beamline and for optimizing the trajectory of the beam at the entry of the plasma-filled drift section.
基金supported by a project of the National Science&Technology Pillar Program during the Twelfth Five-year Plan Period(No.2012BAI29B07)the National Natural Science Foundation of China(No.81202898)
文摘The present study was designed to characterize the chemical constituents of Guge Fengtong Tablet(GGFTT).Based on the chromatographic retention behavior,fragmentation pathways of chemical components and the published literatures,a diagnostic ion filtering strategy with electrospray ionization quadrupole time-of-flight tandem mass spectrometry(HPLC-ESI-Q-TOF/MS) was established to identify the multiple bioactive constituents of GGFTT.The rapid identification of forty-seven components,including 18 phenolic acids,8 saponins,14 gingerol-related compounds,and 7 diarylhepatonoids,was accomplished using this newly developed method.The coupling of HPLC-ESI-Q-TOF/MS with the diagnostic ion filtering strategy was useful and efficient for the in-depth structural elucidation of chemical compounds of GGFTT.
基金supported by the German Research Foundation (DFG) within the Research Training Group GRK 2274the Bundesministerium für Bildung und Forschung (BMBF) within project 01IS17048financial support by the BMBF within projects 05P18WMFA1 and 05P21WMFA1
文摘The acoustic pulse emitted from the Bragg peak of a laser-accelerated proton bunch focused into water has recently enabled the reconstruction of the bunch energy distribution.By adding three ultrasonic transducers and implementing a fast data analysis of the filtered raw signals,I-BEAT(Ion-Bunch Energy Acoustic Tracing)3D now provides the mean bunch energy and absolute lateral bunch position in real-time and for individual bunches.Relative changes in energy spread and lateral bunch size can also be monitored.Our experiments at DRACO with proton bunch energies between 10 and 30 MeV reveal sub-MeV and sub-mm resolution.In addition to this 3D bunch information,the signal strength correlates also with the absolute bunch particle number.
基金supported by the National Natural Science Foundation of China(No.81573550)。
文摘Steroid saponins are secondary metabolites with multiple medicinal values that are found in large quantities in natural medicines,especially Vernonia amygdalina,a famous nature medicine for the treatment of tonsillitis,diabetes,pneumonia.The current study was designed to combine molecular networking(MN)with diagnostic ions for rapid identification ofΔ^(7,9(11))stigmastane-type saponins which were theα-glucosidase inhibitory active substances in V.amygdalina.First,theα-glucosidase inhibitory activities of fiveΔ^(7,9(11))stigmastane-type steroid saponins that were previously isolated were screened,which indicated that theΔ^(7,9(11))stigmastane-type steroid saponin was one of the active constituents responsible for ameliorating diabetes.Furthermore,a strategy was proposed to identify stigmastane-type steroid saponins and verify the plausibility of derived fragmentation pathways by applying MN,MolNetEnhancer and unsupervised substructure annotation(MS2LDA).Based on this strategy,other sevenΔ^(7,9(11))stigmastane-type steroid saponins were identified from this plant.Our research provide scientific evidence for the antidiabetic potential of the steroid saponin-rich extract of V.amygdalina leaf.
基金funding from the Euratom research and training program 2014-2018 and 2019-2020 under grant agreement No.633053funding from LASERLAB-EUROPE(grant agreement No.654148,European Union’s Horizon 2020 research and innovation program)supported by the Ministry of Science and Higher Education of the Russian Federation(Agreement with Joint Institute for High Temperatures RAS No.075-15-2020-785,dated 23 September 2020).
文摘The time-of-flight technique coupled with semiconductor detectors is a powerful instrument to provide real-time characterization of ions accelerated because of laser-matter interactions.Nevertheless,the presence of strong electromagnetic pulses(EMPs)generated during the interactions can severely hinder its employment.For this reason,the diagnostic system must be designed to have high EMP shielding.Here we present a new advanced prototype of detector,developed at ENEA-Centro Ricerche Frascati(Italy),with a large-area(15 mm×15 mm)polycrystalline diamond sensor having 150 μm thickness.The tailored detector design and testing ensure high sensitivity and,thanks to the fast temporal response,high-energy resolution of the reconstructed ion spectrum.The detector was offline calibrated and then successfully tested during an experimental campaign carried out at the PHELIX laser facility(E_(L)~100 J,τ_(L)=750 fs,I_(L)(1-2.5)×10^(19)W/cm^(2))at GSI(Germany).The high rejection to EMP fields was demonstrated and suitable calibrated spectra of the accelerated protons were obtained.
