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磷酸钙骨水泥/聚乳酸羟基乙酸降解产物促进小鼠单核细胞破骨向分化
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作者 龙桂月 李冬冬 廖红兵 《中国组织工程研究》 CAS 北大核心 2023年第8期1193-1198,共6页
背景:前期研究发现磷酸钙骨水泥/聚乳酸羟基乙酸复合材料可加速骨改建过程,其降解产物对单核细胞破骨向分化的影响有待进一步研究。目的:观察磷酸钙骨水泥/聚乳酸羟基乙酸降解产物对小鼠RAW264.7单核细胞破骨向分化的影响。方法:实验分... 背景:前期研究发现磷酸钙骨水泥/聚乳酸羟基乙酸复合材料可加速骨改建过程,其降解产物对单核细胞破骨向分化的影响有待进一步研究。目的:观察磷酸钙骨水泥/聚乳酸羟基乙酸降解产物对小鼠RAW264.7单核细胞破骨向分化的影响。方法:实验分为空白对照组、羟基乙酸组、磷酸钙骨水泥/聚乳酸羟基乙酸组,按照实验分组,将配制好的溶液和50μg/L核因子κB受体活化因子配体添加到完全培养基中制备成不同条件的培养基,培养小鼠RAW264.7细胞5 d,诱导其分化。应用CCK-8法分析各组培养液对细胞增殖作用的影响;RT-PCR和Western blot检测小鼠RAW264.7细胞破骨向分化相关因子活化T细胞核因子c1、基质金属蛋白酶9、核因子κB受体活化因子、抗酒石酸酸性磷酸酶基因和蛋白表达水平的变化;使用抗酒石酸酸性磷酸酶染色法鉴定破骨样细胞。结果与结论:①CCK-8结果显示,细胞在前72 h处于快速生长期,96 h后开始下降;②RT-PCR、Western blot结果显示磷酸钙骨水泥/聚乳酸羟基乙酸组的活化T细胞核因子c1、核因子κB受体活化因子、抗酒石酸酸性磷酸酶mRNA的表达水平及活化T细胞核因子c1、核因子κB受体活化因子的蛋白表达水平显著高于羟基乙酸组、对照组(P<0.05);③羟基乙酸组和磷酸钙骨水泥/聚乳酸羟基乙酸组基质金属蛋白酶9mRNA和蛋白的表达水平差异无显著性意义,但高于对照组(P<0.01);④抗酒石酸酸性磷酸酶染色可见磷酸钙骨水泥/聚乳酸羟基乙酸组破骨样细胞数高于对照组和羟基乙酸组,差异有显著性意义(P<0.05);⑤结果表明磷酸钙骨水泥/聚乳酸羟基乙酸组降解产物形成的微环境可促进小鼠RAW264.7细胞破骨向分化。 展开更多
关键词 磷酸钙骨水泥/聚乳酸羟基乙酸 单核细胞 破骨分化 基质金属蛋白酶9 活化T细胞核因子c1 核因子ΚB受体活化因子
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Recursive constructions for t-covering arrays
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作者 查日军 张德平 徐宝文 《Journal of Southeast University(English Edition)》 EI CAS 2011年第3期340-342,共3页
A t-covering array of size N, degree k, order v and strength t is an N x k array with entries from a set of v symbols such that any N x t subarray contains a t-tuple of v symbols at least once as a row. This paper pre... A t-covering array of size N, degree k, order v and strength t is an N x k array with entries from a set of v symbols such that any N x t subarray contains a t-tuple of v symbols at least once as a row. This paper presents a new algebraic recursive method for constructing covering arrays based on difference matrices. The method can extend parameter factors on the existing covering arrays and cover all the combinations of any t parameter factors (t≥2). The method, which recursively generates high strength covering arrays, is practical. Meanwhile, the theoretical derivation and realization of the proposed algebraic recursive algorithm are given. 展开更多
关键词 covering array orthogonal array difference matrix
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Constructing Pandiagonal Snowflake Magic Squares of Odd Order 被引量:3
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作者 ZHANGShi-de HUQing-wen WANGJi-zhao 《Chinese Quarterly Journal of Mathematics》 CSCD 2004年第2期172-185,共14页
The constructional methods of pandiagonal snowflake magic squares of orders 4m are established in paper [3]. In this paper, the constructional methods of pandiagonal snowflake magic squares of odd orders n are establi... The constructional methods of pandiagonal snowflake magic squares of orders 4m are established in paper [3]. In this paper, the constructional methods of pandiagonal snowflake magic squares of odd orders n are established with n = 6m+l, 6m+5 and 6m+3, m is an odd positive integer and m is an even positive integer 9|6m + 3. It is seen that the number sets for constructing pandiagonal snowflake magic squares can be extended to the matrices with symmetric partial difference in each direction for orders 6m + 1 , 6m + 5; to the trisection matrices with symmetric partial difference in each direction for order 6m + 3. 展开更多
关键词 pandiagonal magic squares matrix with uniform partial difference in each direction matrix with symmetric partial difference in each direction trisection matrix with uniform partial difference in each direction semi-pandiagonal Latin square
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A New Quality Improving Scheme for VQ Decompressed Images Based on DWT 被引量:1
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作者 Yung-Chen Chou Ya-Hsin Lo Jaui-Ji Shen 《Journal of Electronic Science and Technology》 CAS 2013年第1期51-57,共7页
The better compression rate can be achieved by the traditional vector quantization (VQ) method, and the quality of the recovered image can also be accepted. But the decompressed image quality can not be promoted eff... The better compression rate can be achieved by the traditional vector quantization (VQ) method, and the quality of the recovered image can also be accepted. But the decompressed image quality can not be promoted efficiently, so how to balance the image compression rate and image recovering quality is an important issue, in this paper, an image is transformed by discrete wavelet transform (DWT) to generate its DWT transformed image which can be compressed by the VQ method further. Besides, we compute the values between the DWT transformed image and decompressed DWT transformed image as the difference matrix which is the adjustable basis of the decompressed image quality. By controlling the deviation of the difference matrix, there can be nearly Iossless compression for the VQ method. Experimental results show that when the number of compressed bits by our method is equal to the number of those bits compressed by the VQ method, the quality of our recovered image is better. Moreover, the proposed method has more compression capability comparing with the VQ scheme. 展开更多
关键词 Difference matrix discrete wavelet transform image compression vector quantization.
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Research and Design of Coordinated Control Strategy for Smart Electromechanical Actuator System 被引量:1
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作者 HAO Zhenyang ZHANG Qiyao +2 位作者 CHEN Huajie CAO Xin MIAO Wei 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI CSCD 2022年第5期507-520,共14页
In order to improve the frequency response and anti-interference characteristics of the smart electromechanical actuator(EMA)system,and aiming at the force fighting problem when multiple actuators work synchronously,a... In order to improve the frequency response and anti-interference characteristics of the smart electromechanical actuator(EMA)system,and aiming at the force fighting problem when multiple actuators work synchronously,a multi input multi output(MIMO)position difference cross coupling control coordinated strategy based on double‑closed-loop load feedforward control is proposed and designed.In this strategy,the singular value method of return difference matrix is used to design the parameter range that meets the requirements of system stability margin,and the sensitivity function and the H_(∞)norm theory are used to design and determine the optimal solution in the obtained parameter stability region,so that the multi actuator system has excellent synchronization,stability and anti-interference.At the same time,the mathematical model of the integrated smart EMA system is established.According to the requirements of point-to-point control,the controller of double-loop control and load feedforward compensation is determined and designed to improve the frequency response and anti-interference ability of single actuator.Finally,the 270 V high-voltage smart EMA system experimental platform is built,and the frequency response,load feedforward compensation and coordinated control experiments are carried out to verify the correctness of the position difference cross coupling control strategy and the rationality of the parameter design,so that the system can reach the servo control indexes of bandwidth 6 Hz,the maximum output force 20000 N and the synchronization error≤0.1 mm,which effectively solves the problem of force fighting. 展开更多
关键词 smart electromechanical actuator(EMA) force fighting coordinated control strategy cross coupling control singular value method of return difference matrix sensitivity H∞norm control
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A Test of U-type for Goodness-of-fit in Regression Models Through Martingale Difference Divergence
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作者 Kai XU Yan-qin NIE Dao-jiang HE 《Acta Mathematicae Applicatae Sinica》 SCIE CSCD 2024年第4期979-1000,共22页
Based on the martingale difference divergence,a recently proposed metric for quantifying conditional mean dependence,we introduce a consistent test of U-type for the goodness-of-fit of linear models under conditional ... Based on the martingale difference divergence,a recently proposed metric for quantifying conditional mean dependence,we introduce a consistent test of U-type for the goodness-of-fit of linear models under conditional mean restriction.Methodologically,our test allows heteroscedastic regression models without imposing any condition on the distribution of the error,utilizes effectively important information contained in the distance of the vector of covariates,has a simple form,is easy to implement,and is free of the subjective choice of parameters.Theoretically,our mathematical analysis is of own interest since it does not take advantage of the empirical process theory and provides some insights on the asymptotic behavior of U-statistic in the framework of model diagnostics.The asymptotic null distribution of the proposed test statistic is derived and its asymptotic power behavior against fixed alternatives and local alternatives converging to the null at the parametric rate is also presented.In particular,we show that its asymptotic null distribution is very different from that obtained for the true error and their differences are interestingly related to the form expression for the estimated parameter vector embodied in regression function and a martingale difference divergence matrix.Since the asymptotic null distribution of the test statistic depends on data generating process,we propose a wild bootstrap scheme to approximate its null distribution.The consistency of the bootstrap scheme is justified.Numerical studies are undertaken to show the good performance of the new test. 展开更多
关键词 BOOTSTRAP goodness-of-fit test linear mean regression martingale difference divergence martingale difference divergence matrix
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Generalized Latin Matrix and Construction of Orthogonal Arrays
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作者 Shan-qi PANG Li-yan CHEN 《Acta Mathematicae Applicatae Sinica》 SCIE CSCD 2017年第4期1083-1092,共10页
In this paper, generalized Latin matrix and orthogonal generalized Latin matrices are proposed. By using the property of orthogonal array, some methods for checking orthogonal generalized Latin matrices are presented.... In this paper, generalized Latin matrix and orthogonal generalized Latin matrices are proposed. By using the property of orthogonal array, some methods for checking orthogonal generalized Latin matrices are presented. We study the relation between orthogonal array and orthogonal generalized Latin matrices and obtain some useful theorems for their construction. An example is given to illustrate applications of main theorems and a new class of mixed orthogonal arrays are obtained. 展开更多
关键词 orthogonal array generalized Latin matrix orthogonal generalized Latin matrices matrix image generalized permutation difference matrix
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ON MATRIX AND DETERMINANT IDENTITIES FOR COMPOSITE FUNCTIONS
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作者 XinghuaWang Aimin Xu 《Journal of Computational Mathematics》 SCIE CSCD 2011年第1期16-25,共10页
We present some matrix and determinant identities for the divided differences of the composite functions, which generalize the divided difference form of Faa di Bruno's formula. Some recent published identities can b... We present some matrix and determinant identities for the divided differences of the composite functions, which generalize the divided difference form of Faa di Bruno's formula. Some recent published identities can be regarded as special cases of our results. 展开更多
关键词 Bell polynomial Composite function Determinant identity Divided difference matrix identity.
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A Numerical Error Modeling Method for Parallel Kinematic Machines and Its Applications 被引量:1
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作者 刘大炜 王立平 +1 位作者 李铁民 黄鹏 《Tsinghua Science and Technology》 SCIE EI CAS 2010年第5期489-497,共9页
Error model is the basis for accuracy-related computations and analyses for parallel kinematic machines(PKMs).Traditional error modeling methods are usually based on differentiation of kinematic solutions,but the so... Error model is the basis for accuracy-related computations and analyses for parallel kinematic machines(PKMs).Traditional error modeling methods are usually based on differentiation of kinematic solutions,but the solving process is often complex and has limitations for certain specialized PKMs.A concise numerical error modeling method with the inverse kinematic solution as its only requirement is presented in this paper.To avoid complex Jacobian matrix computations,the difference matrix that can be quickly calculated by kinematic solutions was used to replace the differential matrix.The quasi-Newton method,which has high speed and high precision,was introduced to solve the numerical forward kinematic problem.To verify the efficiency of this numerical error modeling method,three applications in error transformation matrix(ETM) modeling,error analysis,and kinematic calibration were simulated on a 4RRR PKM.A comparison with the results obtained by the traditional method shows that the numerical method is accurate,convenient,and has lower requirements and wider applicability,especially for certain specialized and manufactured PKMs. 展开更多
关键词 error model difference matrix quasi-Newton method error transformation matrix(ETM) CALIBRATION
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CONSTRUCTION OF A NEW CLASS OF ORTHOGONAL ARRAYS 被引量:1
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作者 Shanqi PANG 《Journal of Systems Science & Complexity》 SCIE EI CSCD 2007年第3期429-436,共8页
By using the generalized Hadamard product, difference matrix and projection matrices, we present a class of orthogonal projection matrices and related orthogonal arrays of strength two. A new class of orthogonal array... By using the generalized Hadamard product, difference matrix and projection matrices, we present a class of orthogonal projection matrices and related orthogonal arrays of strength two. A new class of orthogonal arrays are constructed. 展开更多
关键词 Difference matrix mixed-level orthogonal array PERMUTATION projection matrix.
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Construction of Orthogonal Arrays without Interaction Columns
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作者 Shan-qi PANG Ya-ping WANG Ming-yao AI 《Acta Mathematicae Applicatae Sinica》 SCIE CSCD 2022年第1期159-168,共10页
In this paper a new class of orthogonal arrays(OAs),i.e.,OAs without interaction columns,are proposed which are applicable in factor screening,interaction detection and other cases.With the tools of difference matrice... In this paper a new class of orthogonal arrays(OAs),i.e.,OAs without interaction columns,are proposed which are applicable in factor screening,interaction detection and other cases.With the tools of difference matrices,we present some general recursive methods for constructing OAs of such type.Several families of OAs with high percent saturation are constructed.In particular,for any integerλ≥3,such a two-level OA of run 4λcan always be obtained if the corresponding Hadamard matrix exists. 展开更多
关键词 complex aliasing difference matrix Hadamard matrix Kronecker sum symmetric array
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The Spectrum of (gv, g, 3, λ)-dDF in Z_(gv)
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作者 Xiao Miao WANG Yan Xun CHANG 《Acta Mathematica Sinica,English Series》 SCIE CSCD 2010年第2期377-392,共16页
In this paper, several recursive constructions for directed difference family and perfect directed difference family are presented by means of difference matrix and incomplete difference matrix. Finally the necessary ... In this paper, several recursive constructions for directed difference family and perfect directed difference family are presented by means of difference matrix and incomplete difference matrix. Finally the necessary and sufficient conditions for the existence of a (gv, g, 3, λ)-directed difference family in Zgv are established. As a consequence, the necessary and sufficient conditions for the existence of a cyclic directed group divisible design with block size three and type gv are obtained. 展开更多
关键词 directed difference family incomplete difference matrix perfect directed difference family
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