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Characterization of the generalized permeability jail in tight reservoirs by analyzing relative-permeability curves and numerical simulation
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作者 Feng-Peng Lai Zhi-Ping Li +1 位作者 He-Xin Wei Wei Zhang 《Petroleum Science》 SCIE EI CSCD 2023年第5期2939-2950,共12页
This study comprehensively characterizes the boundary values of generalized permeability jail in tight reservoirs through relative-permeability curve analysis,numerical simulation,and economic evaluation.A total numbe... This study comprehensively characterizes the boundary values of generalized permeability jail in tight reservoirs through relative-permeability curve analysis,numerical simulation,and economic evaluation.A total number of 108 relative-permeability curves of rock samples from tight reservoirs were obtained,and the characteristics of relative-permeability curves were analyzed.The irreducible water saturation(Swi)mainly ranges from 20% to 70%,and the residual gas saturation(Sgr)ranges from 5% to 15% for 55% of the samples.The relative-permeability curves are categorized into six types(Category-Ⅰ to Ⅵ)by analyzing the following characteristics:The relative permeability of gas at Swi,the relative permeability of water at Sgr,and the relative permeability corresponding to the isotonic point.The relative permeability curves were normalized to facilitate numerical simulation and evaluate the impact of different types of curves on production performance.The results of simulation show significant difference in production performance for different types of relative-permeability curves:Category-Ⅰ corresponds to the case with best well performance,whereas Categories-Ⅴ and Ⅵ correspond to the cases with least production volume.The results of economic evaluation show a generalized permeability jail for Categories-Ⅳ,Ⅴ,and Ⅵ,and the permeability jail develops when the relative permeability of gas and water is below 0.06.This study further quantifies the range of micro-pore parameters corresponding to the generalized permeability jail for a tight sandstone reservoir. 展开更多
关键词 Generalized permeability jail CHARACTERIZATION relative permeability curve Numerical simulation Pore structure
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Experimental analysis of the pore structure, relative permeability, and water flooding characteristics of the Yan'an Formation sandstone, southwestern Ordos Basin
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作者 Ying Yang Xin Zhang +2 位作者 Xiaofeng Zhou Anlun Wang Jiangtao Li 《Energy Geoscience》 2023年第3期182-192,共11页
The oil and gas potential of the Yan'an Formation in the Ordos Basin has yet to be fully tapped. In this study, the pore structure, mobile fluid saturation, and water flooding micro-mechanism of the Yan'an For... The oil and gas potential of the Yan'an Formation in the Ordos Basin has yet to be fully tapped. In this study, the pore structure, mobile fluid saturation, and water flooding micro-mechanism of the Yan'an Formation sandstone are systematically studied through the application of a series of rock physics and fluid experiments. The results show that there is a good positive correlation between porosity and permeability, and the reservoirs are divided into types Ⅰ, Ⅱ, and Ⅲ. Mercury injection tests show that the average pore throat radius of the oil-bearing reservoir ranges from 1 to 7 μm. The displacement pressure of the Yan'an Formation is also relatively low, and it decreases from 0.1 MPa to 0.01 MPa as the rock porosity increases from 11% to 18%. NMR tests show that small (diameter <0.5 μm) and medium pores (diameter ranging from 0.5 to 2.5 μm) are predominant in the reservoir. Different types of reservoirs have different characteristics of relative permeability curve. In addition, when the average oil recovery rate is less than 1 ml/min, the oil displacement efficiency increases faster. However, when the average oil recovery rate is between 1–3.5 ml/min, the oil displacement efficiency is maintained at around 27%–30%. Physical properties of the reservoir, pore-throat structure, experimental pressure difference, and pore volume injected — all have significant effects on oil displacement efficiency. For Type Ⅰ and Type Ⅱ reservoirs, the increase of the pore volume injected has a significant effect on oil displacement efficiency. However, for Type Ⅲ reservoirs, the change of pore volume injected has insignificant effect on oil displacement efficiency. This study provides a reference for the formulation of estimated ultimate recovery (EUR) measures for similar sandstone reservoirs. 展开更多
关键词 Pore suuctue relative permeability test Nudear magnetic Tesonance Water fooding experiment Yan'an Formation Ordos Basin
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Optimization of Gas-Flooding Fracturing Development in Ultra-Low Permeability Reservoirs
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作者 Lifeng Liu Menghe Shi +3 位作者 Jianhui Wang Wendong Wang Yuliang Su Xinyu Zhuang 《Fluid Dynamics & Materials Processing》 EI 2024年第3期595-607,共13页
Ultra-low permeability reservoirs are characterized by small pore throats and poor physical properties, which areat the root of well-known problems related to injection and production. In this study, a gas injection f... Ultra-low permeability reservoirs are characterized by small pore throats and poor physical properties, which areat the root of well-known problems related to injection and production. In this study, a gas injection floodingapproach is analyzed in the framework of numerical simulations. In particular, the sequence and timing of fracturechanneling and the related impact on production are considered for horizontal wells with different fracturemorphologies. Useful data and information are provided about the regulation of gas channeling and possible strategiesto delay gas channeling and optimize the gas injection volume and fracture parameters. It is shown that inorder to mitigate gas channeling and ensure high production, fracture length on the sides can be controlled andlonger fractures can be created in the middle by which full gas flooding is obtained at the fracture location in themiddle of the horizontal well. A Differential Evolution (DE) algorithm is provided by which the gas injectionvolume and the fracture parameters of gas injection flooding can be optimized. It is shown that an improvedoil recovery factor as high as 6% can be obtained. 展开更多
关键词 Ultra-low permeability reservoir gas injection flooding component simulation fracture parameters intelligent optimization differential evolution
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Pore-Throat Combination Types and Gas-Water Relative Permeability Responses of Tight Gas Sandstone Reservoirs in the Zizhou Area of East Ordos Basin, China 被引量:5
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作者 LI Mi GUO Yinghai +2 位作者 LI Zhuangfu WANG Huaichang ZHANG Jingxia 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2019年第3期622-636,共15页
With the aim of better understanding the tight gas reservoirs in the Zizhou area of east Ordos Basin,a total of 222 samples were collected from 50 wells for a series of experiments.In this study,three pore-throat comb... With the aim of better understanding the tight gas reservoirs in the Zizhou area of east Ordos Basin,a total of 222 samples were collected from 50 wells for a series of experiments.In this study,three pore-throat combination types in sandstones were revealed and confirmed to play a controlling role in the distribution of throat size and the characteristics of gas-water relative permeability.The type-I sandstones are dominated by intercrystalline micropores connected by cluster throats,of which the distribution curves of throat size are narrow and have a strong single peak(peak ratio>30%).The pores in the type-II sandstones dominantly consist of secondary dissolution pores and intercrystalline micropores,and throats mainly occur as slice-shaped throats along cleavages between rigid grain margins and cluster throats in clay cement.The distribution curves of throat size for the type-II sandstones show a bimodal distribution with a substantial low-value region between the peaks(peak ratio<15%).Primary intergranular pores and secondary intergranular pores are mainly found in type-III samples,which are connected by various throats.The throat size distribution curves of type-III sandstones show a nearly normal distribution with low kurtosis(peak ratio<10%),and the micro-scale throat radii(>0.5μm)constitute a large proportion.From type-I to type-III sandstones,the irreducible water saturation(Swo)decreased;furthermore,the slope of the curves of Krw/Krg in two-phase saturation zone decreased and the two-phase saturation zone increased,indicating that the gas relative flow ability increased.Variations of the permeability exist in sandstones with different porethroat combination types,which indicate the type-III sandstones are better reservoirs,followed by type-II sandstones and type-I sandstones.As an important factor affecting the reservoir quality,the pore-throat combination type in sandstones is the cumulative expression of lithology and diagenetic modifications with strong heterogeneity. 展开更多
关键词 tight gas sandstone pore-throat COMBINATION type THROAT characteristic GAS-WATER relative permeability Zizhou area ORDOS Basin
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Controlling effects of differential swelling index on evolution of coal permeability 被引量:6
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作者 Chuanzhong Jiang Zhenfeng Zhao +3 位作者 Xiwei Zhang Jishan Liu Derek Elsworth Guanglei Cui 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2020年第3期461-472,共12页
Coal permeability measurements are normally conducted under the assumption that gas pressure in the matrix is equalized with that in fracture and that gas sorption-induced swelling/shrinking strain is uniformly distri... Coal permeability measurements are normally conducted under the assumption that gas pressure in the matrix is equalized with that in fracture and that gas sorption-induced swelling/shrinking strain is uniformly distributed within the coal.However,the validity of this assumption has long been questioned and differential strain between the fracture strain and the bulk strain has long been considered as the primary reason for the inconsistency between experimental data and poroelasticity solutions.Although efforts have been made to incorporate the impact into coal permeability models,the fundamental nature of those efforts to split the matrix strain between fracture and coal bulk remains questionable.In this study,a new concept of differential swelling index(DSI)was derived to theoretically define the relation among sorption-induced strains of the coal bulk,fracture,and coal matrix at the equilibrium state.DSI was a function of the equilibrium pressure and its magnitudes were regulated by the Langmuir constants of both the matrix and the coal bulk.Furthermore,a spectrum of DSI-based coal permeability models was developed to explicitly consider the effect of differential strains.These models were verified with the experimental data under the conditions of uniaxial strain,constant confining pressure,and constant effective stress. 展开更多
关键词 Coal permeability differential swelling behavior Gas adsorption Equilibrium pressure
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Relative permeability estimation of oil-water two-phase flow in shale reservoir 被引量:1
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作者 Yu-Liang Su Ji-Long Xu +2 位作者 Wen-Dong Wang Han Wang Shi-Yuan Zhan 《Petroleum Science》 SCIE CAS CSCD 2022年第3期1153-1164,共12页
Oil-water two-phase flow is ubiquitous in shale strata due to the existence of connate water and the injection of fracturing fluid.In this work,we propose a relative permeability model based on a modified Hagen-Poiseu... Oil-water two-phase flow is ubiquitous in shale strata due to the existence of connate water and the injection of fracturing fluid.In this work,we propose a relative permeability model based on a modified Hagen-Poiseuille(HP)equation and shale reconstruction algorithm.The proposed model can consider the nanoconfined effects(slip length and spatially varying viscosity),oil-water distribution,pore size distribution(PSD),total organic matter content(TOC),and micro-fracture.The results show that the increasing contact angles of organic matters(OM)and inorganic minerals(iOM)increase the relative permeability of both oil and water.As the viscosity ratio increases,the relative permeability of oil phase increases while that of water phase decreases,due to the different water-oil distribution.The effective permeability of both oil and water decreases with the increasing TOC.However,the relative permeability of water phase increases while that of oil phase decreases.The increasing number and decreasing deviation angle of micro-fracture increase the effective permeability of oil and water.However,microfracture has a minor effect on relative permeability.Our model can help understand oil-water twophase flow in shale reservoirs and provide parameter characterization for reservoir numerical simulation. 展开更多
关键词 SHALE relative permeability Two-phase flow TOC Analytical model
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The Influence Law of Oil Relative Permeability on Water Cut 被引量:1
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作者 Yanhui Zhang Yingxian Liu +2 位作者 Hongyou Zhang Mengjun Bie Guangyi Sun 《Journal of Geoscience and Environment Protection》 2018年第9期223-232,共10页
Water cut is a key evaluation parameter for reservoir development evaluation. Relative permeability curve reflects reservoir characteristics and fluid characteristics. It is important to figure out the influence law o... Water cut is a key evaluation parameter for reservoir development evaluation. Relative permeability curve reflects reservoir characteristics and fluid characteristics. It is important to figure out the influence law of oil relative permeability on water cut. Based on the 269 relative permeability curves of Bohai oilfields, the distribution of oil index of Bohai oilfields were studied. On the basis, combined with Corey expression of relative permeability and fractional flow equation, the theoretical relationship between oil index and water cut increasing rate was established. Three end points of water cut increasing rate curve were proposed and the influence law between three end points and oil index was studied. The results show that the oil index has a linear relationship with three end points. When the value of water oil mobile ratio is large than 1, with the increase of oil index, maximum value of water cut increasing rate gradually increase. When the value of water oil mobile ratio is less than 10, oil index has great effect on recovery percent when water cut increasing rate reaches to the maximum value as well as water cut when water cut increasing rate reaches to the maximum value. The application of SS field shows that the theoretical value is consistent with the field data. 展开更多
关键词 Water CUT INCREASING Rate OIL relative permeability OIL index End Point of relative permeability CURVE
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Estimation of the water–oil–gas relative permeability curve from immiscible WAG coreflood experiments using the cubic B-spline model
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作者 Dai-Gang Wang Yong-Le Hu +1 位作者 Jing-Jing Sun Yong Li 《Petroleum Science》 SCIE CAS CSCD 2016年第3期507-516,共10页
Immiscible water-alternating-gas(WAG) flooding is an EOR technique that has proven successful for water drive reservoirs due to its ability to improve displacement and sweep efficiency.Nevertheless,considering the com... Immiscible water-alternating-gas(WAG) flooding is an EOR technique that has proven successful for water drive reservoirs due to its ability to improve displacement and sweep efficiency.Nevertheless,considering the complicated phase behavior and various multiphase flow characteristics,gas tends to break through early in production wells in heterogeneous formations because of overriding,fingering,and channeling,which may result in unfavorable recovery performance.On the basis of phase behavior studies,minimum miscibility pressure measurements,and immiscible WAG coreflood experiments,the cubic B-spline model(CBM) was employed to describe the three-phase relative permeability curve.Using the Levenberg-Marquardt algorithm to adjust the vector of unknown model parameters of the CBM sequentially,optimization of production performance including pressure drop,water cut,and the cumulative gas-oil ratio was performed.A novel numerical inversion method was established for estimation of the water-oil-gas relative permeability curve during the immiscible WAG process.Based on the quantitative characterization of major recovery mechanisms,the proposed method was validated by interpreting coreflood data of the immiscible WAG experiment.The proposed method is reliable and can meet engineering requirements.It provides a basic calculation theory for implicit estimation of oil-water-gas relative permeability curve. 展开更多
关键词 Cubic B-spline model IMMISCIBLE WAG flooding relative permeability Numerical inversion
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Effect of H_(2)S content on relative permeability and capillary pressure characteristics of acid gas/brine/rock systems:A review
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作者 Xiaoyan Zhang Qi Li +2 位作者 Mathias Simon Guodong Zheng Yongsheng Tan 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2022年第6期2003-2033,共31页
Geological storage of acid gas has been identified as a promising approach to reduce atmospheric carbon dioxide(CO_(2)),hydrogen sulfide(H_(2)S)and alleviate public concern resulting from the sour gas production.A goo... Geological storage of acid gas has been identified as a promising approach to reduce atmospheric carbon dioxide(CO_(2)),hydrogen sulfide(H_(2)S)and alleviate public concern resulting from the sour gas production.A good understanding of the relative permeability and capillary pressure characteristics is crucial to predict the process of acid gas injection and migration.The prediction of injection and redistribution of acid gas is important to determine storage capacity,formation pressure,plume extent,shape,and leakage potential.Herein,the existing experimental data and theoretical models were reviewed to gain a better understanding of the issue how the H_(2)S content affects gas density,gas viscosity,interfacial tension,wettability,relative permeability and capillary pressure characteristics of acid gas/brine/rock systems.The densities and viscosities of the acid gas with different H_(2)S mole fractions are both temperature-and pressure-dependent,which vary among the gas,liquid and supercritical phases.Water/acid gas interfacial tension decreases strongly with increasing H_(2)S content.For mica and clean quartz,water contact angle increases with increasing H_(2)S mole fraction.In particular,wettability reversal of mica to a H_(2)S-wet behavior occurs in the presence of dense H_(2)S.The capillary pressure increases with decreasing contact angle.At a given saturation,the relative permeability of a fluid is higher when the fluid is nonwetting.The capillary pressure decreases with decreasing interfacial tension at a given saturation.However,the existing datasets do not show a consistent link between capillary number and relative permeability.The capillary pressure decreases with increasing H_(2)S mole fraction.However,there is no consensus on the effect of the H_(2)S content on the relative permeability curves.This may be due to the limited availability of the relative permeability and capillary pressure data for acid gas/brine/rock systems;thus,more experimental measurements are required. 展开更多
关键词 Acid gas geological sequestration relative permeability Capillary pressure H_(2)S content Wettability Interfacial tension
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Classification Study on Relative Permeability Curves
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作者 Pingzhi Gong Bin Liu +2 位作者 Junting Zhang Zheng Lv Guohao Zhang 《World Journal of Engineering and Technology》 2018年第4期723-737,共15页
The classification method of relative permeability curves is rarely reported, when relative permeability curves are applied;if the multiple relative permeability curves are normalized directly, but not classified, the... The classification method of relative permeability curves is rarely reported, when relative permeability curves are applied;if the multiple relative permeability curves are normalized directly, but not classified, the calculated result maybe cause a large error. For example, the relationship curve between oil displacement efficiency and water cut, which derived from the relative permeability curve in LD oilfield is uncertain in the shape of low water cut stage. If being directly normalized, the result of the interpretation of the water flooded zone is very high. In this study, two problems were solved: 1) The mathematical equation of the relationship between oil displacement efficiency and water cut was deduced, and repaired the lost data of oil displacement efficiency and water cut curve, which solve the problem of uncertain curve shape. After analysis, the reason why the curve is not available is that relative permeability curves are not classified and optimized;2) Two kinds of classification and evaluation methods of relative permeability curve were put forward, the direct evaluation method and the analogy method;it can get the typical relative permeability curve by identifying abnormal curve. 展开更多
关键词 relative permeability CURVE DISPLACEMENT Efficiency CLASSIFICATION CORRECTION
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Numerical simulation-based correction of relative permeability hysteresis in water-invaded underground gas storage during multi-cycle injection and production
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作者 ZHU Sinan SUN Junchang +4 位作者 WEI Guoqi ZHENG Dewen WANG Jieming SHI Lei LIU Xianshan 《Petroleum Exploration and Development》 CSCD 2021年第1期190-200,共11页
By conducting relative permeability experiments of multi-cycle gas-water displacement and imbibition on natural cores,we discuss relative permeability hysteresis effect in underground gas storage during multi-cycle in... By conducting relative permeability experiments of multi-cycle gas-water displacement and imbibition on natural cores,we discuss relative permeability hysteresis effect in underground gas storage during multi-cycle injection and production.A correction method for relative permeability hysteresis in numerical simulation of water-invaded gas storage has been worked out using the Carlson and Killough models.A geologic model of water-invaded sandstone gas storage with medium-low permeability is built to investigate the impacts of relative permeability hysteresis on fluid distribution and production performance during multi-cycle injection and production of the gas storage.The study shows that relative permeability hysteresis effect occurs during high-speed injection and production in gas storage converted from water-invaded gas reservoir,and leads to increase of gas-water transition zone width and thickness,shrinkage of the area of high-efficiency gas storage,and decrease of the peak value variation of pore volume containing gas,and then reduces the storage capacity,working gas volume,and high-efficiency operation span of the gas storage.Numerical simulations exhibit large prediction errors of performance indexes if this hysteresis effect is not considered.Killough and Carlson methods can be used to correct the relative permeability hysteresis effect in water-invaded underground gas storage to improve the prediction accuracy.The Killough method has better adaptability to the example model. 展开更多
关键词 water-invaded gas reservoir underground gas storage multicycle injection-production relative permeability hysteresis model-based correction index prediction
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A Method for Calculating Oil Field Relative Permeability Curve by Using Water Drive Characteristic Curve in High Water Cut Stage
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作者 Juan Du 《Journal of Geoscience and Environment Protection》 2022年第2期47-54,共8页
With the production of strong bottom water reservoir, it will soon enter the ultra-high water cut stage. After entering the ultra-high water cut period, the main means of stable production is liquid extraction. Large ... With the production of strong bottom water reservoir, it will soon enter the ultra-high water cut stage. After entering the ultra-high water cut period, the main means of stable production is liquid extraction. Large liquid volume has a certain impact on the physical property distribution and fluid seepage law of the oilfield. The relative permeability curve measured according to the industry standard is not used for the prediction of development indicators and the understanding of the dynamic law of the oilfield. In order to understand the characteristics of water drive law in high water cut stage of water drive oilfield, starting from the water drive characteristic curve in high water cut stage, the method for calculating the relative permeability curve is deduced. Through numerical simulation verification and fitting the actual production data, it is confirmed that the obtained relative permeability curve is in line with the reality of the oilfield, It can provide some guiding significance for understanding the production law and water drive law of strong bottom water reservoir in ultra-high water cut stage. 展开更多
关键词 Strong Bottom Water Reservoir High Water Cut Stage Water Drive Curve relative permeability Curve
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差序整合:农村互助养老实现的机制分析
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作者 郝亚光 潘琼 《云南社会科学》 北大核心 2024年第2期140-148,共9页
农村互助养老作为居家养老和机构养老的重要补充,是解决农村深度老龄化问题的有效路径。基于差序格局理论,在“关系—制度”分析框架和“差序整合”概念下,通过对河南省W县农村互助养老实践的考察发现,当地基层党组织成功借助乡土社会... 农村互助养老作为居家养老和机构养老的重要补充,是解决农村深度老龄化问题的有效路径。基于差序格局理论,在“关系—制度”分析框架和“差序整合”概念下,通过对河南省W县农村互助养老实践的考察发现,当地基层党组织成功借助乡土社会关系的差序规则,有序动员老人的亲友、邻里、同乡等为其提供养老服务。究其实现机制,具体包括以重塑认知为重点的制度嵌入、以均衡互利为核心的关系整合、以满足需求为关键的行动激励、以责任践履为要求的多方问责机制,差序整合为农村互助养老的可持续发展提供了规引制度、关系基础、参与动力和履责保障,实现了社会关系、制度规约、行动主体的全面整合,推动了农村养老服务高质量发展。 展开更多
关键词 农村互助养老 社会关系 差序整合 人口老龄化
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资源下乡背景下乡村关系的差序格局及其形塑逻辑
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作者 姜国俊 《中南大学学报(社会科学版)》 北大核心 2024年第1期136-146,共11页
以“一乡−多村”为乡村关系的两个主体,突破过去将乡村关系中的“村”视为一个抽象整体的研究进路,提出“乡村关系的差序格局”。在“行政消解自治”乡村一体化的背景下,乡镇与其下辖的各行政村的关系存在“亲疏远近”之别。形塑这种亲... 以“一乡−多村”为乡村关系的两个主体,突破过去将乡村关系中的“村”视为一个抽象整体的研究进路,提出“乡村关系的差序格局”。在“行政消解自治”乡村一体化的背景下,乡镇与其下辖的各行政村的关系存在“亲疏远近”之别。形塑这种亲疏远近的要素主要有三个:一是特定行政村在中央或地方涉农政策中的重要性。政策性位置越突出,其与乡镇的关系越亲近。二是特定行政村村治情况良善与否。村干部治村能力越强,其与乡镇的关系越亲近。三是特定行政村在体制内有无先赋性外联关系。这种外联关系越重要,其与乡镇的关系越亲近。自上而下的各类资源在各行政村之间的配置,相应由乡村关系的差序格局来形塑。 展开更多
关键词 资源下乡 乡村关系 差序格局 驻村工作队 政绩思维
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Screening Rat Hypertension-Related Genes By Differential Display
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作者 曹宇清 张晨晖 +2 位作者 李倩虹 徐平 周爱儒 《北京大学学报(医学版)》 CAS CSCD 1994年第S1期56-62,共7页
ScreeningRatHypertension-RelatedGenesByDifferentialDisplayCaoYuqing曹宇清,ZhangChenhui张晨晖,LiQianhong李倩虹,XuPing徐... ScreeningRatHypertension-RelatedGenesByDifferentialDisplayCaoYuqing曹宇清,ZhangChenhui张晨晖,LiQianhong李倩虹,XuPing徐平,ZhouAiru周爱儒,and... 展开更多
关键词 differential DISPLAY Hypertension- related gene VASCULAR SMOOTH MUSCLE cells
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国医大师王晞星分期辨治胃癌癌因性疲乏经验采菁
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作者 石智尧 刘佳佳 +4 位作者 高宇 孙祎濛 张谷庆 张晓男 王晞星 《长春中医药大学学报》 2024年第2期150-154,共5页
王晞星教授认为,胃癌患者癌因性疲乏发生病机为脏腑功能失常、气血阴阳不足,具体可划分早期“脾胃两伤”、进展期“痰瘀互结”、末期“肾虚精亏”。针对此过程,提出不同阶段治法为早期“固本培元、清热解毒”、进展期“化瘀消痰、攻补... 王晞星教授认为,胃癌患者癌因性疲乏发生病机为脏腑功能失常、气血阴阳不足,具体可划分早期“脾胃两伤”、进展期“痰瘀互结”、末期“肾虚精亏”。针对此过程,提出不同阶段治法为早期“固本培元、清热解毒”、进展期“化瘀消痰、攻补兼施”、末期“抗癌托毒、滋补肝肾”。选用补中益气汤、六君子汤、血府逐瘀汤、桂枝茯苓丸、滋水清肝饮、三棱、莪术、浙贝母、蜈蚣等方药。临证治疗时注重“和”法思维,病证结合,效果显著。 展开更多
关键词 胃癌 癌因性疲乏 虚劳 分期论治 王晞星
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羊栖菜中的褐藻糖胶通过影响MAPK信号通路对表皮屏障的修复治疗
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作者 李涛 张琪 +3 位作者 王妍 罗晓焱 高艺恬 吴明江 《沈阳药科大学学报》 CAS CSCD 2024年第1期102-111,共10页
目的探讨羊栖菜褐藻糖胶(Sargassum fusiforme fucoidan,SFF)对表皮屏障损伤的修复作用。评价SFF对角质形成细胞增殖、迁移和分化的影响。方法使用BrdU和CCK8试剂盒分析SFF对HaCaT细胞的增殖作用影响;划痕法测定SFF对HaCaT细胞的迁移作... 目的探讨羊栖菜褐藻糖胶(Sargassum fusiforme fucoidan,SFF)对表皮屏障损伤的修复作用。评价SFF对角质形成细胞增殖、迁移和分化的影响。方法使用BrdU和CCK8试剂盒分析SFF对HaCaT细胞的增殖作用影响;划痕法测定SFF对HaCaT细胞的迁移作用;流式细胞仪、qPCR和蛋白免疫印迹检测SFF对HaCaT细胞中mRNA表达和蛋白表达的影响。构建表皮屏障受损模型,通过经皮水散失、组织学观察等实验确定SFF对受损表皮屏障的体内修复作用。结果显示SFF以剂量依赖方式显著促进HaCaT细胞的增殖及迁移。此外,SFF能上调HaCaT细胞分化标志物的基因表达,通过激活ERK和JNK通路促进表皮角质形成细胞的增殖、迁移和分化。体内研究表明,与基质组相比,SFF处理组能促进表皮通透性屏障的恢复率,显著增加水合作用。结论SFF能够影响MAPK信号通路调节紊乱的角质形成细胞功能,作为治疗表皮屏障损伤的潜在药物或功能性化妆品添加成分。 展开更多
关键词 表皮屏障功能损伤 羊栖菜多糖 角质形成细胞 增殖 分化 迁移
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蔡小平治疗肿瘤相关性抑郁的临床经验
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作者 晁瑞 魏征 +1 位作者 张俊萍 蔡小平 《中医肿瘤学杂志》 2024年第2期62-67,共6页
肿瘤相关性抑郁是恶性肿瘤确诊及治疗过程中出现的病理性的抑郁状态,主要表现为恐惧、兴趣减退等,不仅使肿瘤患者更加痛苦,也不利于疾病本身的治疗。西医治疗有一定的局限性,患者病情初期,仅仅服用中药,病情就可以得到明显的改善,若不... 肿瘤相关性抑郁是恶性肿瘤确诊及治疗过程中出现的病理性的抑郁状态,主要表现为恐惧、兴趣减退等,不仅使肿瘤患者更加痛苦,也不利于疾病本身的治疗。西医治疗有一定的局限性,患者病情初期,仅仅服用中药,病情就可以得到明显的改善,若不予以重视,则会恶化,甚至进展为难治性抑郁。蔡小平教授通过认为肿瘤相关性抑郁与肿瘤及其伴随的治疗密切相关,初则及气,渐及血分,久则伤及肝肾之阴,可从痰气交阻、肝胃不和、肝郁脾虚、心脾两虚、血虚脏躁及肝肾阴虚6个方面进行辨证论治,治疗以行气化痰、疏肝清肝、疏肝健脾、补益心脾、和中缓急及滋肾养肝为主,取得了良好的临床疗效;本文对其辨证治疗肿瘤相关性抑郁的临床经验进行整理,为临床实践提供参考。 展开更多
关键词 肿瘤相关抑郁 临床经验 蔡小平 辨证论治
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干性年龄相关性黄斑变性中西医治疗研究进展
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作者 孙婉钰 李欣 张红 《中国中医眼科杂志》 2024年第4期374-377,391,共5页
年龄相关性黄斑变性(AMD)是导致老年人致盲的常见性眼病,随着全球人口老龄化的加剧,AMD已成为全球性问题。根据眼底的不同表现,AMD在可分为2种类型,即干性AMD(dAMD)和湿性AMD(wAMD)。抗血管内皮生长因子作为一线药物治疗wAMD已取得显著... 年龄相关性黄斑变性(AMD)是导致老年人致盲的常见性眼病,随着全球人口老龄化的加剧,AMD已成为全球性问题。根据眼底的不同表现,AMD在可分为2种类型,即干性AMD(dAMD)和湿性AMD(wAMD)。抗血管内皮生长因子作为一线药物治疗wAMD已取得显著疗效,而dAMD尚无明确的治疗方法。本文通过梳理国内外文献,针对dAMD的中、西医治疗进展进行综述,发现西医治疗主要包括补体抑制、神经保护、基因治疗、干细胞治疗、抗炎、抗氧化治疗等;中医治疗本病主要从肝、脾、肾出发,病证结合、辨证论治。但目前研究样本量均较小,尚缺乏大样本、多中心随机对照试验为本病的治疗提供有力的证据支持。 展开更多
关键词 干性年龄相关性黄斑变性 中医 西医 辨证论治
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模仿IgG4相关淋巴结病的多中心型Castleman病:易误诊病例的鉴别诊断及文献复习
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作者 李春艳 刘国荣 +2 位作者 常丽君 李秀博 丁文双 《广州医药》 2024年第2期121-126,共6页
目的通过学习1例少见的组织学特征与IgG4相关性淋巴结病类似的浆细胞型特发性多中心型Castleman病(PC-iMCD),总结两种易误诊疾病的鉴别要点,提高病理诊断水平。方法回顾性分析1例PC-iMCD患者临床资料,常规苏木素-伊红(HE)染色分析淋巴... 目的通过学习1例少见的组织学特征与IgG4相关性淋巴结病类似的浆细胞型特发性多中心型Castleman病(PC-iMCD),总结两种易误诊疾病的鉴别要点,提高病理诊断水平。方法回顾性分析1例PC-iMCD患者临床资料,常规苏木素-伊红(HE)染色分析淋巴结组织结构及细胞形态,免疫组织化学染色及原位杂交分析免疫表型及EB病毒(EBV)感染状态,并结合文献分析讨论其与IgG4相关淋巴结病的鉴别诊断。结果48岁女性患者,临床表现为口干、多饮、皮肤瘙痒伴全身多处淋巴结肿大。实验室检查血清IgG、IgA、IgM及IgE水平均升高,血清IgG4显著升高(14.7 g/L),白介素-6(IL-6)异常升高(150.84 pg/mL)。病理检查显示淋巴结生发中心萎缩,套区淋巴细胞呈“洋葱皮”样围绕生发中心排列,滤泡间区扩张,其内见大量成熟的浆细胞呈片状浸润,灶区见含铁血黄素沉积及血管增生;免疫组化染色显示IgG4阳性浆细胞数大于100/高倍视野,IgG4阳性细胞/IgG阳性细胞比值>40%,Kappa及Lambda轻链呈非限制性表达;EB病毒编码RNA原位杂交(EBER)阴性。结论部分PC-iMCD与IgG4相关淋巴结病具有相似的组织病理学特征,单纯根据组织学及免疫表型难以将两者鉴别,正确诊断需结合IgG4相关病变诊断标准、排除性诊断标准、临床表现及实验室检查综合判断。 展开更多
关键词 CASTLEMAN病 IgG4相关淋巴结病 淋巴结 浆细胞 鉴别诊断
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