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High-Precision Doppler Frequency Estimation Based Positioning Using OTFS Modulations by Red and Blue Frequency Shift Discriminator 被引量:1
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作者 Shaojing Wang Xiaomei Tang +3 位作者 Jing Lei Chunjiang Ma Chao Wen Guangfu Sun 《China Communications》 SCIE CSCD 2024年第2期17-31,共15页
Orthogonal Time Frequency and Space(OTFS) modulation is expected to provide high-speed and ultra-reliable communications for emerging mobile applications, including low-orbit satellite communications. Using the Dopple... Orthogonal Time Frequency and Space(OTFS) modulation is expected to provide high-speed and ultra-reliable communications for emerging mobile applications, including low-orbit satellite communications. Using the Doppler frequency for positioning is a promising research direction on communication and navigation integration. To tackle the high Doppler frequency and low signal-to-noise ratio(SNR) in satellite communication, this paper proposes a Red and Blue Frequency Shift Discriminator(RBFSD) based on the pseudo-noise(PN) sequence.The paper derives that the cross-correlation function on the Doppler domain exhibits the characteristic of a Sinc function. Therefore, it applies modulation onto the Delay-Doppler domain using PN sequence and adjusts Doppler frequency estimation by red-shifting or blue-shifting. Simulation results show that the performance of Doppler frequency estimation is close to the Cramér-Rao Lower Bound when the SNR is greater than -15dB. The proposed algorithm is about 1/D times less complex than the existing PN pilot sequence algorithm, where D is the resolution of the fractional Doppler. 展开更多
关键词 channel estimation communication and navigation integration Orthogonal Time Frequency and Space pseudo-noise sequence red-blue frequency shift discriminator
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A Dual Discriminator Method for Generalized Zero-Shot Learning
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作者 Tianshu Wei Jinjie Huang 《Computers, Materials & Continua》 SCIE EI 2024年第4期1599-1612,共14页
Zero-shot learning enables the recognition of new class samples by migrating models learned from semanticfeatures and existing sample features to things that have never been seen before. The problems of consistencyof ... Zero-shot learning enables the recognition of new class samples by migrating models learned from semanticfeatures and existing sample features to things that have never been seen before. The problems of consistencyof different types of features and domain shift problems are two of the critical issues in zero-shot learning. Toaddress both of these issues, this paper proposes a new modeling structure. The traditional approach mappedsemantic features and visual features into the same feature space;based on this, a dual discriminator approachis used in the proposed model. This dual discriminator approach can further enhance the consistency betweensemantic and visual features. At the same time, this approach can also align unseen class semantic features andtraining set samples, providing a portion of information about the unseen classes. In addition, a new feature fusionmethod is proposed in the model. This method is equivalent to adding perturbation to the seen class features,which can reduce the degree to which the classification results in the model are biased towards the seen classes.At the same time, this feature fusion method can provide part of the information of the unseen classes, improvingits classification accuracy in generalized zero-shot learning and reducing domain bias. The proposed method isvalidated and compared with othermethods on four datasets, and fromthe experimental results, it can be seen thatthe method proposed in this paper achieves promising results. 展开更多
关键词 Generalized zero-shot learning modality consistent discriminator domain shift problem feature fusion
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EDU-GAN:Edge Enhancement Generative Adversarial Networks with Dual-Domain Discriminators for Inscription Images Denoising
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作者 Yunjing Liu Erhu Zhang +2 位作者 Jingjing Wang Guangfeng Lin Jinghong Duan 《Computers, Materials & Continua》 SCIE EI 2024年第7期1633-1653,共21页
Recovering high-quality inscription images from unknown and complex inscription noisy images is a challenging research issue.Different fromnatural images,character images pay more attention to stroke information.Howev... Recovering high-quality inscription images from unknown and complex inscription noisy images is a challenging research issue.Different fromnatural images,character images pay more attention to stroke information.However,existingmodelsmainly consider pixel-level informationwhile ignoring structural information of the character,such as its edge and glyph,resulting in reconstructed images with mottled local structure and character damage.To solve these problems,we propose a novel generative adversarial network(GAN)framework based on an edge-guided generator and a discriminator constructed by a dual-domain U-Net framework,i.e.,EDU-GAN.Unlike existing frameworks,the generator introduces the edge extractionmodule,guiding it into the denoising process through the attention mechanism,which maintains the edge detail of the restored inscription image.Moreover,a dual-domain U-Net-based discriminator is proposed to learn the global and local discrepancy between the denoised and the label images in both image and morphological domains,which is helpful to blind denoising tasks.The proposed dual-domain discriminator and generator for adversarial training can reduce local artifacts and keep the denoised character structure intact.Due to the lack of a real-inscription image,we built the real-inscription dataset to provide an effective benchmark for studying inscription image denoising.The experimental results show the superiority of our method both in the synthetic and real-inscription datasets. 展开更多
关键词 Dual-domain discriminators inscription images DENOISING edge-guided generator
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A Multi-Task Motion Generation Model that Fuses a Discriminator and a Generator
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作者 Xiuye Liu Aihua Wu 《Computers, Materials & Continua》 SCIE EI 2023年第7期543-559,共17页
The human motion generation model can extract structural features from existing human motion capture data,and the generated data makes animated characters move.The 3D human motion capture sequences contain complex spa... The human motion generation model can extract structural features from existing human motion capture data,and the generated data makes animated characters move.The 3D human motion capture sequences contain complex spatial-temporal structures,and the deep learning model can fully describe the potential semantic structure of human motion.To improve the authenticity of the generated human motion sequences,we propose a multi-task motion generation model that consists of a discriminator and a generator.The discriminator classifies motion sequences into different styles according to their similarity to the mean spatial-temporal templates from motion sequences of 17 crucial human joints in three-freedom degrees.And target motion sequences are created with these styles by the generator.Unlike traditional related works,our model can handle multiple tasks,such as identifying styles and generating data.In addition,by extracting 17 crucial joints from 29 human joints,our model avoids data redundancy and improves the accuracy of model recognition.The experimental results show that the discriminator of the model can effectively recognize diversified movements,and the generated data can correctly fit the actual data.The combination of discriminator and generator solves the problem of low reuse rate of motion data,and the generated motion sequences are more suitable for actual movement. 展开更多
关键词 Human motion discriminator GENERATOR human motion generation model multi-task processing performance motion style
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Analysis of Multipath and CW Interference Effects on GNSS Receivers with EMLP Discriminator 被引量:2
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作者 Bo Qu Jiaolong Wei +1 位作者 Shuangna Zhang Liang Bi 《Communications and Network》 2013年第3期80-85,共6页
Multipath and continuous wave (CW) interference may cause severe performance degradation of global navigation satellite system (GNSS) receivers. This paper analyzes the code tracking performance of early-minus-late po... Multipath and continuous wave (CW) interference may cause severe performance degradation of global navigation satellite system (GNSS) receivers. This paper analyzes the code tracking performance of early-minus-late power (EMLP) discriminator of GNSS receivers in the presence of multipath and CW interference. An analytical expression of the code tracking error is suggested for EMLP discriminator, and it can be used to assess the effect of multipath and CW interference. The derived expression shows that the combined effects include three components: multipath component;CW interference component and the combined component of multipath and CW interference. The effect of these components depends on some factors which can be classified into two categories: the receiving environment and the receiver parameters. Numerical results show how these factors affect the tracking performances. It is shown that the proper receiver parameters can suppress the combined effects of multipath and CW interference. 展开更多
关键词 ANALYSIS of MULTIPATH and CW Interference Effects on GNSS RECEIVERS with EMLP discriminator
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A New Self-assembly Metal CMG Discriminator by Multi-exposure LiGA Like Process and Sacrificial Layer Process 被引量:1
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作者 张卫平 陈文元 +2 位作者 赵小林 丁桂甫 李胜勇 《Journal of Donghua University(English Edition)》 EI CAS 2005年第4期91-93,共3页
The counter-meshing gears (CMG) discriminator is a mechanically coded lock, which is used to prevent the occurrence of High Consequence Events. This paper advanced a new kind of self-assembly metal CMG discriminator... The counter-meshing gears (CMG) discriminator is a mechanically coded lock, which is used to prevent the occurrence of High Consequence Events. This paper advanced a new kind of self-assembly metal CMG discriminator based on multi-exposure LiGA like process and sacrificial layer process. The new CMG discriminator has the following characters except low cost: 1) it has only discrimination teeth sections; 2) the thickness of each gear layer exceeds one hundred micrometers; 3) it is axially driven by a separate dectronic magnetic micromotor directly; 4) its CMG is made of metal and is batch fabricated in the assembled state; 5) it is prevented from rotating in the opposite direction by pawl/ratchet wheel mechanism; 6) it has simpler structure. This device has better strength and reliability in abnormal environment compared to the existing surface micro machining (SMM) discriminator. 展开更多
关键词 Counter-meshing gears (CMG) discriminator multi-exposure LiGA like process sacrificial layer process.
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Mathematical Model of Non-Coherent-DLL Discriminator Output and Multipath Envelope Error for BOC (α, β) Modulated Signals 被引量:1
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作者 Khaled Rouabah Chebir Saifeddine +2 位作者 Salim Atia Mustapha Flissi Djamel Chikouche 《Positioning》 2013年第1期65-79,共15页
In this paper we propose the derivation of the expressions for the non-coherent Delay Locked Loop (DLL) Discriminator Curve (DC) in the absence and presence of Multipath (MP). Also derived, are the expressions of MP t... In this paper we propose the derivation of the expressions for the non-coherent Delay Locked Loop (DLL) Discriminator Curve (DC) in the absence and presence of Multipath (MP). Also derived, are the expressions of MP tracking errors in non-coherent configuration. The proposed models are valid for all Binary Offset Carrier (BOC) modulated signals in Global Navigation Satellite Systems (GNSS) such as Global Positioning System (GPS) and Future Galileo. The non-coherent configuration is used whenever the phase of the received signal cannot be estimated and thus cannot be demodulated. Therefore, the signal must be treated in a transposed band by the non-coherent DLL. The computer implementations show that the proposed models coincide with the numerical ones. 展开更多
关键词 BOC Modulation GNSS PRN Code MULTIPATH discriminator ENVELOPE ERROR
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Analog rise-time discriminator for CdZnTe detector
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作者 Chuan-Hao Hu Guo-Qiang Zeng +4 位作者 Liang-Quan Ge Shi-Long Wei Jian Yang Qiang Li Hong-Zhi Li 《Nuclear Science and Techniques》 SCIE CAS CSCD 2017年第4期59-65,共7页
Due to variable time for charge collection,energy resolution of nuclear detectors declines,especially compound semiconductor detectors like cadmium zinc telluride(CdZnTe) detector.To solve this problem,an analog rise-... Due to variable time for charge collection,energy resolution of nuclear detectors declines,especially compound semiconductor detectors like cadmium zinc telluride(CdZnTe) detector.To solve this problem,an analog rise-time discriminator based on charge comparison principle is designed.The reference charge signal after attenuation is compared with the deconvoluted and delayed current signal.It is found that the amplitude of delayed current signal is higher than that of the reference charge signal when rise time of the input signal is shorter than the discrimination time,thus generating gating signal and triggering DMCA(digital multi-channel analyzer) to receive the total integral charge signal.When rise time of the input signal is longer than discrimination time,DMCA remains inactivated and the corresponding total integral charge signal is abandoned.Test results show that combination of the designed rise-time discriminator and DMCA can reduce hole tailing of CdZnTe detector significantly.Energy resolution of the system is 0.98%@662 keV,and it is still excellent under high counting rates. 展开更多
关键词 ANALOG rise-time discriminator CDZNTE detector Charge comparison PRINCIPLE
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Reinforced CNN Forensic Discriminator to Detect Document Forgery by DCGAN
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作者 Seo-young Lim Jeongho Cho 《Computers, Materials & Continua》 SCIE EI 2022年第6期6039-6051,共13页
Recently,the technology of digital image forgery based on a generative adversarial network(GAN)has considerably improved to the extent that it is difficult to distinguish it from the original image with the naked eye ... Recently,the technology of digital image forgery based on a generative adversarial network(GAN)has considerably improved to the extent that it is difficult to distinguish it from the original image with the naked eye by compositing and editing a person’s face or a specific part with the original image.Thus,much attention has been paid to digital image forgery as a social issue.Further,document forgery through GANs can completely change the meaning and context in a document,and it is difficult to identify whether the document is forged or not,which is dangerous.Nonetheless,few studies have been conducted on document forgery and new forgery-related attacks have emerged daily.Therefore,in this study,we propose a novel convolutional neural network(CNN)forensic discriminator that can detect forged text or numeric images by GANs using CNNs,which have been widely used in image classification for many years.To strengthen the detection performance of the proposed CNN forensic discriminator,CNN was trained after image preprocessing,including salt and pepper as well asGaussian noises.Moreover,we performed CNN optimization to make existing CNN more suitable for forged text or numeric image detection,which have mainly focused on the discrimination of forged faces to date.The test evaluation results using Hangul texts and numbers showed that the accuracy of forgery discrimination of the proposed method was significantly improved by 20%in Hangul texts and 5%in numbers compared with that of existing state-of-the-art methods,which proved the proposed model performance superiority and verified that it could be a useful tool in reducing crime potential. 展开更多
关键词 Digital forensics CNN GAN discriminator image processing
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Perceptual Image Outpainting Assisted by Low-Level Feature Fusion and Multi-Patch Discriminator
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作者 Xiaojie Li Yongpeng Ren +5 位作者 Hongping Ren Canghong Shi Xian Zhang Lutao Wang Imran Mumtaz Xi Wu 《Computers, Materials & Continua》 SCIE EI 2022年第6期5021-5037,共17页
Recently,deep learning-based image outpainting has made greatly notable improvements in computer vision field.However,due to the lack of fully extracting image information,the existing methods often generate unnatural... Recently,deep learning-based image outpainting has made greatly notable improvements in computer vision field.However,due to the lack of fully extracting image information,the existing methods often generate unnatural and blurry outpainting results in most cases.To solve this issue,we propose a perceptual image outpainting method,which effectively takes the advantage of low-level feature fusion and multi-patch discriminator.Specifically,we first fuse the texture information in the low-level feature map of encoder,and simultaneously incorporate these aggregated features reusability with semantic(or structural)information of deep feature map such that we could utilizemore sophisticated texture information to generate more authentic outpainting images.Then we also introduce a multi-patch discriminator to enhance the generated texture,which effectively judges the generated image from the different level features and concurrently impels our network to produce more natural and clearer outpainting results.Moreover,we further introduce perceptual loss and style loss to effectively improve the texture and style of outpainting images.Compared with the existing methods,our method could produce finer outpainting results.Experimental results on Places2 and Paris StreetView datasets illustrated the effectiveness of our method for image outpainting. 展开更多
关键词 Deep learning image outpainting low-level feature fusion multi-patch discriminator
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OBLIQUE PROJECTION REALIZATION OF A KERNEL-BASED NONLINEAR DISCRIMINATOR
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作者 Liu Benyong Zhang Jing 《Journal of Electronics(China)》 2006年第1期94-98,共5页
Previously, a novel classifier called Kernel-based Nonlinear Discriminator (KND) was proposed to discriminate a pattern class from other classes by minimizing mean effect of the latter. To consider the effect of the t... Previously, a novel classifier called Kernel-based Nonlinear Discriminator (KND) was proposed to discriminate a pattern class from other classes by minimizing mean effect of the latter. To consider the effect of the target class, this paper introduces an oblique projection algorithm to determine the coefficients of a KND so that it is extended to a new version called extended KND (eKND). In eKND construction, the desired output vector of the target class is obliquely projected onto the relevant subspace along the subspace related to other classes. In addition, a simple technique is proposed to calculate the associated oblique projection operator. Experimental results on handwritten digit recognition show that the algorithm performes better than a KND classifier and some other commonly used classifiers. 展开更多
关键词 Pattern recognition Nonlinear classifier Kernel-based Nonlinear discriminator(KND) Extended KND(eKND) Handwritten digit recognition
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A real-time neutron-gamma discriminator based on the support vector machine method for the time-of-flight neutron spectrometer 被引量:3
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作者 张伟 吴彤宇 +3 位作者 郑博文 李世平 张轶泼 阴泽杰 《Plasma Science and Technology》 SCIE EI CAS CSCD 2018年第4期170-175,共6页
A new neutron-gamma discriminator based on the support vector machine(SVM) method is proposed to improve the performance of the time-of-flight neutron spectrometer. The neutron detector is an EJ-299-33 plastic scintil... A new neutron-gamma discriminator based on the support vector machine(SVM) method is proposed to improve the performance of the time-of-flight neutron spectrometer. The neutron detector is an EJ-299-33 plastic scintillator with pulse-shape discrimination(PSD) property. The SVM algorithm is implemented in field programmable gate array(FPGA) to carry out the real-time sifting of neutrons in neutron-gamma mixed radiation fields. This study compares the ability of the pulse gradient analysis method and the SVM method. The results show that this SVM discriminator can provide a better discrimination accuracy of 99.1%. The accuracy and performance of the SVM discriminator based on FPGA have been evaluated in the experiments. It can get a figure of merit of 1.30. 展开更多
关键词 plasma diagnosis support vector machine pulse-shape discrimination TOF spectrometer
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Research of Frequency Discriminator on Frequency Lock Loops 被引量:1
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作者 徐颖 吴嗣亮 王菊 《Journal of Beijing Institute of Technology》 EI CAS 2008年第4期462-465,共4页
Frequency lock loops (FLL) discriminating algorithms for direct-sequence spread-spectrum are discussed. The existing algorithms can't solve the problem of data bit reversal during one pre-detection integral period.... Frequency lock loops (FLL) discriminating algorithms for direct-sequence spread-spectrum are discussed. The existing algorithms can't solve the problem of data bit reversal during one pre-detection integral period. And when the initial frequency offset is large, the frequency discriminator can' t work normally. To solve these problems, a new FLL discriminating algorithm is introduced. The least-squares discriminator is used in this new algorithm. As the least-squares discriminator has a short process unit period, the correspond- ing frequency discriminating range is large. And the data bit reversal just influence one process unit period, so the least-squares discriminated result will not be affected. Compared with traditional frequency discriminator, the least-squares algorithm can effectively solve the problem of data bit reversal and can endure larger initial frequency offset. 展开更多
关键词 frequency discriminating four-quadrant arctangent LEAST-SQUARES
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Organizations in science and medicine must hold each other accountable for discriminatory practices
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作者 Julie K Silver 《四川生理科学杂志》 2022年第8期1486-1486,共1页
Many organizations persist in working with others that engage in known,remediable structural discrimination.We name this practice interorganizational structural discrimination(ISD)and argue it is a pivotal contributor... Many organizations persist in working with others that engage in known,remediable structural discrimination.We name this practice interorganizational structural discrimination(ISD)and argue it is a pivotal contributor to inequities in science and medicine.We urge organizations to leverage their relationships and demand progress from collaborators. 展开更多
关键词 organizations DISCRIMINATION ENGAGE
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I-DCGAN and TOPSIS-IFP:A simulation generation model for radiographic flaw detection images in light alloy castings and an algorithm for quality evaluation of generated images
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作者 Ming-jun Hou Hao Dong +7 位作者 Xiao-yuan Ji Wen-bing Zou Xiang-sheng Xia Meng Li Ya-jun Yin Bao-hui Li Qiang Chen Jian-xin Zhou 《China Foundry》 SCIE EI CAS CSCD 2024年第3期239-247,共9页
The intelligent detection technology driven by X-ray images and deep learning represents the forefront of advanced techniques and development trends in flaw detection and automated evaluation of light alloy castings.H... The intelligent detection technology driven by X-ray images and deep learning represents the forefront of advanced techniques and development trends in flaw detection and automated evaluation of light alloy castings.However,the efficacy of deep learning models hinges upon a substantial abundance of flaw samples.The existing research on X-ray image augmentation for flaw detection suffers from shortcomings such as poor diversity of flaw samples and low reliability of quality evaluation.To this end,a novel approach was put forward,which involves the creation of the Interpolation-Deep Convolutional Generative Adversarial Network(I-DCGAN)for flaw detection image generation and a comprehensive evaluation algorithm named TOPSIS-IFP.I-DCGAN enables the generation of high-resolution,diverse simulated images with multiple appearances,achieving an improvement in sample diversity and quality while maintaining a relatively lower computational complexity.TOPSIS-IFP facilitates multi-dimensional quality evaluation,including aspects such as diversity,authenticity,image distribution difference,and image distortion degree.The results indicate that the X-ray radiographic images of magnesium and aluminum alloy castings achieve optimal performance when trained up to the 800th and 600th epochs,respectively.The TOPSIS-IFP value reaches 78.7%and 73.8%similarity to the ideal solution,respectively.Compared to single index evaluation,the TOPSIS-IFP algorithm achieves higher-quality simulated images at the optimal training epoch.This approach successfully mitigates the issue of unreliable quality associated with single index evaluation.The image generation and comprehensive quality evaluation method developed in this paper provides a novel approach for image augmentation in flaw recognition,holding significant importance for enhancing the robustness of subsequent flaw recognition networks. 展开更多
关键词 light alloy casting flaw detection image generator discriminator comprehensive evaluation index
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Constant fraction discriminator in pulsed time-of-flight laser rangefinding 被引量:4
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作者 Ruitong ZHENG GuanhaoWU 《Frontiers of Optoelectronics》 2012年第2期182-186,共5页
Constant fraction discriminator (CFD) is one of theoretic method which can locate timing point at same fraction of echo pulse in pulsed time-of-flight (TOF) laser rangefinding. In this paper, the theory of CFD met... Constant fraction discriminator (CFD) is one of theoretic method which can locate timing point at same fraction of echo pulse in pulsed time-of-flight (TOF) laser rangefinding. In this paper, the theory of CFD method was analyzed in reality condition. The design, simulation and printed-circuit-board (PCB) performance of CFD circuit were shown. Finally, an over amplified method was introduced, by which the influence of direct-current (DC) bias error could be reduced. The experimental results showed that timing discriminator could set the timing point to a certain point on echo pulse, which did not depend on the amplitude of echo pulse. 展开更多
关键词 constant fraction discriminator (CFD) time-of-flight (TOF) pulsed TOF laser rangending direct-current(DC) bias error
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A novel joint navigation state error discriminator based on iterative maximum likelihood estimation 被引量:2
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作者 WANG YongQing LUO Yu +1 位作者 WANG Pai WU SiLiang 《Science China Chemistry》 SCIE EI CAS CSCD 2015年第12期115-128,共14页
To break through the limitations of traditional discriminators used in vector tracking loops, this paper presents an iterative maximum likelihood estimation(IMLE) method for extracting navigation state errors from mul... To break through the limitations of traditional discriminators used in vector tracking loops, this paper presents an iterative maximum likelihood estimation(IMLE) method for extracting navigation state errors from multi-satellite signals. The IMLE method takes into account both computational cost and estimation accuracy. The associated gradient vector and Hessian matrix of the MLE cost function are derived. The characteristics of the proposed joint discriminator are analyzed based on the properties of the MLE cost function,gradient vector, and Hessian matrix. The effectiveness of IMLE is verified by Monte Carlo simulation. 展开更多
关键词 global navigation satellite system (GNSS) iterative maximum likelihood estimation (IMLE) jointnavigation state error discriminator Cramer-Rao bound (CRB) vector tracking loop
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Underwater Pulse Waveform Recognition Based on Hash Aggregate Discriminant Network
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作者 WANG Fangchen ZHONG Guoqiang WANG Liang 《Journal of Ocean University of China》 SCIE CAS CSCD 2024年第3期654-660,共7页
Underwater pulse waveform recognition is an important method for underwater object detection.Most existing works focus on the application of traditional pattern recognition methods,which ignore the time-and space-vary... Underwater pulse waveform recognition is an important method for underwater object detection.Most existing works focus on the application of traditional pattern recognition methods,which ignore the time-and space-varying characteristics in sound propagation channels and cannot easily extract valuable waveform features.Sound propagation channels in seawater are time-and space-varying convolutional channels.In the extraction of the waveform features of underwater acoustic signals,the effect of high-accuracy underwater acoustic signal recognition is identified by eliminating the influence of time-and space-varying convolutional channels to the greatest extent possible.We propose a hash aggregate discriminative network(HADN),which combines hash learning and deep learning to minimize the time-and space-varying effects on convolutional channels and adaptively learns effective underwater waveform features to achieve high-accuracy underwater pulse waveform recognition.In the extraction of the hash features of acoustic signals,a discrete constraint between clusters within a hash feature class is introduced.This constraint can ensure that the influence of convolutional channels on hash features is minimized.In addition,we design a new loss function called aggregate discriminative loss(AD-loss).The use of AD-loss and softmax-loss can increase the discriminativeness of the learned hash features.Experimental results show that on pool and ocean datasets,which were collected in pools and oceans,respectively,by using acoustic collectors,the proposed HADN performs better than other comparative models in terms of accuracy and mAP. 展开更多
关键词 convolutional channel hash aggregate discriminative network aggregate discriminant loss waveform recognition
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Discrimination of polysorbate 20 by high-performance liquid chromatography-charged aerosol detection and characterization for components by expanding compound database and library
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作者 Shi-Qi Wang Xun Zhao +10 位作者 Li-Jun Zhang Yue-Mei Zhao Lei Chen Jin-Lin Zhang Bao-Cheng Wang Sheng Tang Tom Yuan Yaozuo Yuan Mei Zhang Hian Kee Lee Hai-Wei Shi 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2024年第5期722-732,共11页
Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual tolerance.The similar structures and polarities of PS20 compon... Analyzing polysorbate 20(PS20)composition and the impact of each component on stability and safety is crucial due to formulation variations and individual tolerance.The similar structures and polarities of PS20 components make accurate separation,identification,and quantification challenging.In this work,a high-resolution quantitative method was developed using single-dimensional high-performance liquid chromatography(HPLC)with charged aerosol detection(CAD)to separate 18 key components with multiple esters.The separated components were characterized by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UHPLC-Q-TOF-MS)with an identical gradient as the HPLC-CAD analysis.The polysorbate compound database and library were expanded over 7-time compared to the commercial database.The method investigated differences in PS20 samples from various origins and grades for different dosage forms to evaluate the composition-process relationship.UHPLC-Q-TOF-MS identified 1329 to 1511 compounds in 4 batches of PS20 from different sources.The method observed the impact of 4 degradation conditions on peak components,identifying stable components and their tendencies to change.HPLC-CAD and UHPLC-Q-TOF-MS results provided insights into fingerprint differences,distinguishing quasi products. 展开更多
关键词 Polysorbate 20 Component DATABASE DISCRIMINATION Degradation
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LociScan,a tool for screening genetic marker combinations for plant variety discrimination
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作者 Yang Yang Hongli Tian +5 位作者 Hongmei Yi Zi Shi Lu Wang Yaming Fan Fengge Wang Jiuran Zhao 《The Crop Journal》 SCIE CSCD 2024年第2期583-593,共11页
To reduce the cost and increase the efficiency of plant genetic marker fingerprinting for variety discrimination,it is desirable to identify the optimal marker combinations.We describe a marker combination screening m... To reduce the cost and increase the efficiency of plant genetic marker fingerprinting for variety discrimination,it is desirable to identify the optimal marker combinations.We describe a marker combination screening model based on the genetic algorithm(GA)and implemented in a software tool,Loci Scan.Ratio-based variety discrimination power provided the largest optimization space among multiple fitness functions.Among GA parameters,an increase in population size and generation number enlarged optimization depth but also calculation workload.Exhaustive algorithm afforded the same optimization depth as GA but vastly increased calculation time.In comparison with two other software tools,Loci Scan accommodated missing data,reduced calculation time,and offered more fitness functions.In large datasets,the sample size of training data exerted the strongest influence on calculation time,whereas the marker size of training data showed no effect,and target marker number had limited effect on analysis speed. 展开更多
关键词 Plant variety discrimination Genetic marker combination Variety discrimination power Genetic algorithm
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