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Synthesis of pH-responsive triazine skeleton nano-polymer composite containing AIE group for drug delivery
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作者 Yifan ZHANG Xueying PENG +6 位作者 Xinbo JING Lin CUI Shengchao YANG Jianning WU Guihua MENG Zhiyong LIU Xuhong GUO 《Frontiers of Materials Science》 SCIE CSCD 2021年第1期113-123,共11页
We exploited a unique porous structure of the nano-covalent triazinepolymer(NCTP)containing aggregation-induced emission(AlE)group to achievecontrolled release and drug tracking in tumor acidic microenvironment.NCTP w... We exploited a unique porous structure of the nano-covalent triazinepolymer(NCTP)containing aggregation-induced emission(AlE)group to achievecontrolled release and drug tracking in tumor acidic microenvironment.NCTP wassynthesized by the Friedel-Crafts alkylation and the McMurry coupling reaction.It notonly had strong doxorubicin(DOX)-loading capacity due to its high specific surface areaand large pore volume,but also showed the significant cumulative drug release as aresult of the pH response of triazine polymers.NCTP was induced luminescence aftermass accumulation near tumor cells.Besides,it had excellent biocompatibility andobvious antineoplastic toxicity.The results demonstrate that NCTP as a utility-type drugcarrier provides a new route for designing the multi-functional drug delivery platform. 展开更多
关键词 triazine skeleton structure pH response aggregation-induced emission drug dolivery
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