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BIG HANKEL OPERATORS ON HARDY SPACES OF STRONGLY PSEUDOCONVEX DOMAINS
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作者 陈伯勇 江良英 《Acta Mathematica Scientia》 SCIE CSCD 2024年第3期789-809,共21页
In this article,we investigate the(big) Hankel operator H_(f) on the Hardy spaces of bounded strongly pseudoconvex domains Ω in C^(n).We observe that H_(f ) is bounded on H~p(Ω)(1 <p <∞) if f belongs to BMO a... In this article,we investigate the(big) Hankel operator H_(f) on the Hardy spaces of bounded strongly pseudoconvex domains Ω in C^(n).We observe that H_(f ) is bounded on H~p(Ω)(1 <p <∞) if f belongs to BMO and we obtain some characterizations for Hf on H^(2)(Ω) of other pseudoconvex domains.In these arguments,Amar's L^(p)-estimations and Berndtsson's L^(2)-estimations for solutions of the ■_(b)-equation play a crucial role.In addition,we solve Gleason's problem for Hardy spaces H^(p)(Ω)(1 ≤p≤∞) of bounded strongly pseudoconvex domains. 展开更多
关键词 Hankel operator Hardy space Bergman space pseudoconvex domain
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Time-Domain Higher-Order Boundary Element Method for Simulating High Forward-Speed Ship Motions in Waves
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作者 ZHOU Xiao-guo CHENG Yong PAN Su-yong 《China Ocean Engineering》 SCIE EI CSCD 2024年第5期904-914,共11页
The hydrodynamic performance of a high forward-speed ship in obliquely propagating waves is numerically examined to assess both free motions and wave field in comparison with a low forward-speed ship.This numerical mo... The hydrodynamic performance of a high forward-speed ship in obliquely propagating waves is numerically examined to assess both free motions and wave field in comparison with a low forward-speed ship.This numerical model is based on the time-domain potential flow theory and higher-order boundary element method,where an analytical expression is completely expanded to determine the base-unsteady coupling flow imposed on the moving condition of the ship.The ship in the numerical model may possess different advancing speeds,i.e.stationary,low speed,and high speed.The role of the water depth,wave height,wave period,and incident wave angle is analyzed by means of the accurate numerical model.It is found that the resonant motions of the high forward-speed ship are triggered by comparison with the stationary one.More specifically,a higher forward speed generates a V-shaped wave region with a larger elevation,which induces stronger resonant motions corresponding to larger wave periods.The shoaling effect is adverse to the motion of the low-speed ship,but is beneficial to the resonant motion of the high-speed ship.When waves obliquely propagate toward the ship,the V-shaped wave region would be broken due to the coupling effect between roll and pitch motions.It is also demonstrated that the maximum heave motion occurs in beam seas for stationary cases but occurs in head waves for high speeds.However,the variation of the pitch motion with period is hardly affected by wave incident angles. 展开更多
关键词 high forward speed oblique incident waves ship motion higher-order boundary element method time domain wave field
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人参皂苷Rd促进创伤性脑损伤后的内源性神经发生和相关机制研究
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作者 马进 袁华 +4 位作者 顾毓庭 郭志强 冯秋鹏 刘华 夏晓华 《徐州医科大学学报》 CAS 2024年第8期547-552,共6页
目的探讨人参皂苷Rd(GSRd)对创伤性脑损伤(TBI)后内源性神经发生的影响及可能机制。方法取SD雄性大鼠随机分为假手术组、溶剂组和GSRd组。应用液压损伤装置制备大鼠TBI模型,然后尾静脉注射GSRd进行治疗。采用水迷宫实验检测大鼠的学习... 目的探讨人参皂苷Rd(GSRd)对创伤性脑损伤(TBI)后内源性神经发生的影响及可能机制。方法取SD雄性大鼠随机分为假手术组、溶剂组和GSRd组。应用液压损伤装置制备大鼠TBI模型,然后尾静脉注射GSRd进行治疗。采用水迷宫实验检测大鼠的学习记忆能力,采用ROS、MDA、SOD试剂盒检测大鼠体内氧化应激水平,采用qPCR法检测损伤区皮质细胞线粒体损伤情况,采用TUENL试剂盒检测损伤区皮质细胞凋亡情况,采用Western blot法检测大鼠海马组织中双肾上腺皮质激素(DCX)蛋白水平,采用NeuN/BrdU免疫荧光法检测损伤区皮质新生神经元情况。结果与溶剂组比较,GSRd组大鼠逃避潜伏期显著缩短,平台穿越次数显著增加,差异有统计学意义(P<0.05);ROS和MDA水平显著降低,SOD活力显著升高,差异有统计学意义(P<0.05);GSRd治疗能抑制损伤区皮质细胞线粒体DNA拷贝数的下降,缓解大鼠损伤区皮质的细胞凋亡,提高损伤侧海马及皮质的神经发生,差异有统计学意义(P<0.05)。结论GSRd能促进TBI大鼠内源性神经发生及学习记忆能力的恢复,这可能与抑制氧化应激及线粒体损伤并减少细胞凋亡有关。 展开更多
关键词 人参皂苷rd 创伤性脑损伤 内源性神经发生 氧化应激 线粒体损伤 凋亡
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miR-592靶向调控PRDM5影响肾细胞癌侵袭转移及自噬的机制研究
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作者 李顺来 宋晓琳 +1 位作者 姜亭起 王文祯 《医学分子生物学杂志》 CAS 2024年第3期239-246,共8页
目的探究miR-592靶向调控PR结构域锌指蛋白5(PR domain zinc finger protein 5,PRDM5)影响肾细胞癌(renal cell carcinoma,RCC)侵袭转移及自噬的机制。方法RT-qPCR、蛋白质印迹检测RCC组织和细胞中miR-592、PRDM5 mRNA和蛋白水平。A498... 目的探究miR-592靶向调控PR结构域锌指蛋白5(PR domain zinc finger protein 5,PRDM5)影响肾细胞癌(renal cell carcinoma,RCC)侵袭转移及自噬的机制。方法RT-qPCR、蛋白质印迹检测RCC组织和细胞中miR-592、PRDM5 mRNA和蛋白水平。A498、786-O细胞分为anti-miR-NC组、anti-miR-592组、anti-miR-592+si-NC组、anti-miR-592+si-PRDM5组。RNA免疫共沉淀(RIP)检测miR-592和PRDM5的结合;CCK-8、Transwell实验检测细胞增殖、迁移和侵袭能力;透射电镜观察自噬小体形成;蛋白质印迹检测细胞PRDM5、基质金属蛋白酶(MMP)-2、MMP-9、Beclin1、微管相关蛋白1轻链3(LC3)Ⅱ/Ⅰ水平。建立移植瘤裸鼠模型,分析敲低miR-592表达对移植瘤生长的影响。结果RCC组织和细胞中PRDM5 mRNA和蛋白水平降低,miR-592水平增加(P<0.05)。敲低miR-592表达后,细胞A_(450 nm)、迁移和侵袭细胞数、MMP-2、MMP-9水平降低,自噬小体数量、Beclin1、LC3Ⅱ/Ⅰ水平增加(P<0.05)。敲低PRDM5表达能部分逆转敲低miR-592对细胞增殖、侵袭及自噬的影响(P<0.05)。敲低miR-592表达能够抑制裸鼠移植瘤生长(P<0.05)。结论miR-592通过靶向抑制PRDM5表达,促进RCC细胞增殖、侵袭转移能力,并抑制自噬能力。 展开更多
关键词 miR-592 PR结构域锌指蛋白5 肾细胞癌 侵袭转移 自噬
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基于GADF融合RDSAN的跨工况轴承故障诊断
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作者 瞿红春 韩松钰 +3 位作者 贾柏谊 马文博 詹亦宏 台合泽 《组合机床与自动化加工技术》 北大核心 2024年第7期182-187,共6页
针对在不同工况下获取到的滚动轴承振动数据特征分布存在差异,以及由于存在噪声而导致故障特征不明显的问题,提出了一种融合格拉姆角差场(GADF)与残差深度子领域自适应(RDSAN)模型的跨工况轴承故障诊断方法。首先,为充分利用GADF在故障... 针对在不同工况下获取到的滚动轴承振动数据特征分布存在差异,以及由于存在噪声而导致故障特征不明显的问题,提出了一种融合格拉姆角差场(GADF)与残差深度子领域自适应(RDSAN)模型的跨工况轴承故障诊断方法。首先,为充分利用GADF在故障特征差异化显示上的优势,利用GADF来生成滚动轴承一维振动时域信号对应的图像数据集;其次,将数据集输入RDSAN模型,其中使用由改进图像集预训练的ResNet-18网络结构进行源域与目标域通用特征的进一步提取,并引入局部最大均值差异(LMMD)计算匹配条件分布距离进行子领域自适应;最后,在添加0.5 dB高斯白噪声的CWRU滚动轴承数据集上进行跨工况试验验证,结果表明所提方法的平均诊断精度达到96.8%;将所提出的方法与不同的诊断方法进行比较分析,结果验证了该方法的有效性和优越性。 展开更多
关键词 滚动轴承 故障诊断 跨工况 格拉姆角差场 子领域自适应
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人参皂苷Rd通过下调DRP1介导的线粒体分裂缓解哮喘
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作者 李祎 马立光 《中国病理生理杂志》 CAS CSCD 北大核心 2024年第7期1237-1243,共7页
目的:探讨人参皂苷Rd通过发动蛋白相关蛋白1(DRP1)介导的线粒体分裂缓解蟑螂提取物(CRE)诱导的哮喘小鼠气道炎症的分子机制。方法:动物(BALB/c小鼠)和细胞(人气道上皮BEAS-2B细胞)实验均设置对照组、模型组(CRE组)、CRE+低剂量人参皂苷R... 目的:探讨人参皂苷Rd通过发动蛋白相关蛋白1(DRP1)介导的线粒体分裂缓解蟑螂提取物(CRE)诱导的哮喘小鼠气道炎症的分子机制。方法:动物(BALB/c小鼠)和细胞(人气道上皮BEAS-2B细胞)实验均设置对照组、模型组(CRE组)、CRE+低剂量人参皂苷Rd组、CRE+高剂量人参皂苷Rd组和CRE+地塞米松组。利用HE染色法观察肺组织病理改变;ELISA及流式细胞术检测辅助性T细胞(Th1/Th2)因子水平;Western blot和荧光染色法检测活性氧(ROS)产生、线粒体分裂蛋白及线粒体形态。结果:人参皂苷Rd显著减轻CRE诱导的小鼠气道周围炎症细胞浸润,降低血清总免疫球蛋白E(IgE)和CRE特异性IgE水平(P<0.05),以及支气管肺泡灌洗液中嗜酸性粒细胞比例(P<0.05),纠正Th1/Th2失衡(P<0.05)。人参皂苷Rd还可降低模型小鼠肺组织和CRE诱导的BEAS-2B细胞中DRP1、p-DRP1(Ser616)和线粒体分裂蛋白1(FIS1)水平(P<0.05),改善线粒体形态,抑制ROS产生。结论:人参皂苷Rd通过下调DRP1介导的线粒体分裂,减轻CRE诱导的哮喘气道炎症。本研究对人参皂苷Rd在哮喘模型中的免疫药理作用提出了新的见解。 展开更多
关键词 人参皂苷rd 发动蛋白相关蛋白1 线粒体 哮喘
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基于网络药理学探索人参皂苷Rd抗结肠癌的关键靶点及作用机制
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作者 李慧娟 卢静 +1 位作者 李强 陆以霞 《黑龙江医学》 2024年第19期2315-2318,共4页
目的:通过网络药理学联合分子对接技术,探讨人参皂苷Rd抗结肠癌的分子机制。方法:在Swiss Target Prediction数据库中搜索参皂苷Rd搜索对应靶点的活性成分,从GeneCards数据库及OMIM数据库筛选结肠癌的靶点,将交集靶点进行功能富集和生... 目的:通过网络药理学联合分子对接技术,探讨人参皂苷Rd抗结肠癌的分子机制。方法:在Swiss Target Prediction数据库中搜索参皂苷Rd搜索对应靶点的活性成分,从GeneCards数据库及OMIM数据库筛选结肠癌的靶点,将交集靶点进行功能富集和生物学途径分析,通过Cytoscape软件绘制蛋白质互作网络(PPI),并将排序前4的核心靶点与人参皂苷Rd的进行分子对接。结果:通过网络药理学分析发现人参皂苷Rd治疗结肠癌的关键靶点为44个;本体富集(GO)分析结果显示,包括2 406个生物过程(BP)、48个细胞成分(CC)和169个分子功能(MF);京都基因与基因组百科全书(KEGG)结果发现了91个信号通路。将排列前4的核心靶点与人参皂苷Rd进行分子对接,结果表明人参皂苷Rd对关键靶点具有有效的结合热。结论:MMP9、IL2、NR3C1、JUN、PTGS2、STAT3、PRSS1、F2RL1、CYP27B1和F2是人参皂苷Rd治疗结肠癌的关键靶点,可能通过PI3K/Akt信号通路、MAPK信号通路、Wnt信号通路等抑制结肠癌,后续可通过基础实验进一步验证。 展开更多
关键词 人参皂苷rd 结肠癌 网络药理学 作用机制 分子对接
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Fast solution to the free return orbit's reachable domain of the manned lunar mission by deep neural network
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作者 YANG Luyi LI Haiyang +1 位作者 ZHANG Jin ZHU Yuehe 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第2期495-508,共14页
It is important to calculate the reachable domain(RD)of the manned lunar mission to evaluate whether a lunar landing site could be reached by the spacecraft. In this paper, the RD of free return orbits is quickly eval... It is important to calculate the reachable domain(RD)of the manned lunar mission to evaluate whether a lunar landing site could be reached by the spacecraft. In this paper, the RD of free return orbits is quickly evaluated and calculated via the classification and regression neural networks. An efficient databasegeneration method is developed for obtaining eight types of free return orbits and then the RD is defined by the orbit’s inclination and right ascension of ascending node(RAAN) at the perilune. A classify neural network and a regression network are trained respectively. The former is built for classifying the type of the RD, and the latter is built for calculating the inclination and RAAN of the RD. The simulation results show that two neural networks are well trained. The classification model has an accuracy of more than 99% and the mean square error of the regression model is less than 0.01°on the test set. Moreover, a serial strategy is proposed to combine the two surrogate models and a recognition tool is built to evaluate whether a lunar site could be reached. The proposed deep learning method shows the superiority in computation efficiency compared with the traditional double two-body model. 展开更多
关键词 manned lunar mission free return orbit reachable domain(rd) deep neural network computation efficiency
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食品级商业酶转化人参皂苷Rb1制备人参皂苷Rd研究
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作者 曹锦雯 李涵涵 +2 位作者 王思涵 千文 杨长青 《广东化工》 CAS 2024年第20期45-48,共4页
在11种不同厂家食品级商业酶中筛选出转化人参皂苷Rb1制备Rd活性最佳的酶,并利用单因素实验考察反应时间、酶量、初始pH及温度对转化效率的影响。结果显示,β-葡聚糖酶(庞博)的转化活性最高,其最佳转化条件为反应时间2 h,酶量0.3 mg/1.5... 在11种不同厂家食品级商业酶中筛选出转化人参皂苷Rb1制备Rd活性最佳的酶,并利用单因素实验考察反应时间、酶量、初始pH及温度对转化效率的影响。结果显示,β-葡聚糖酶(庞博)的转化活性最高,其最佳转化条件为反应时间2 h,酶量0.3 mg/1.5 mg Rb1,pH 5.5和55℃,Rd转化效率为98.01%±1.19%(n=3)。β-葡聚糖酶(庞博)酶转化法是一种高效、绿色、安全的人参皂苷Rd制备方法。 展开更多
关键词 Β-葡聚糖酶 酶转化 人参皂苷rd 人参皂苷RB1 商业酶
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滋阴明目方对视网膜色素变性rd10小鼠PERK-ATF4信号通路的影响
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作者 谢薇 宋厚盼 +3 位作者 彭俊 徐剑 欧晨 彭清华 《湖南中医药大学学报》 CAS 2024年第9期1568-1574,共7页
目的研究滋阴明目方对视网膜色素变性小鼠的影响及其可能机制。方法将60只rd10小鼠随机分为模型组(等量生理盐水)、维生素A(Vitamin A,VitA)组[VitA 750 IU/(kg·d)]及滋阴明目方低、中、高剂量组[滋阴明目方水煎液13.5、27、54 g/(... 目的研究滋阴明目方对视网膜色素变性小鼠的影响及其可能机制。方法将60只rd10小鼠随机分为模型组(等量生理盐水)、维生素A(Vitamin A,VitA)组[VitA 750 IU/(kg·d)]及滋阴明目方低、中、高剂量组[滋阴明目方水煎液13.5、27、54 g/(kg·d)],12只C57BL/6小鼠作为空白组(等量生理盐水),均灌胃干预28 d。HE染色观察视网膜组织病理改变,TUNEL法检测视网膜组织凋亡,微滴式数字PCR和免疫荧光双染检测视网膜组织蛋白激酶样内质网激酶(protein kinase RNA-like endoplasmic reticulum kinase,PERK)、活化转录因子4(activating transcription factor 4,ATF4)mRNA和蛋白的表达。结果与空白组比较,模型组小鼠视网膜明显萎缩、变薄,视网膜色素上皮(retinal pigment epithelial,RPE)细胞不可见,外核层消失,视网膜厚度减小(P<0.01),小鼠视网膜细胞数量明显减少,存在大量凋亡细胞;PERK、ATF4 mRNA和蛋白表达量升高(P<0.01)。与模型组比较,VitA组和滋阴明目方各剂量组视网膜状况改善,厚度均增加(P<0.01);细胞数量增多,凋亡细胞减少;PERK、ATF4 mRNA表达量降低(P<0.01)。与模型组比较,VitA组和滋阴明目方中、高剂量组PERK、ATF4蛋白表达量降低(P<0.01);滋阴明目方低剂量组ATF4蛋白表达量降低(P<0.01)。与滋阴明目方低剂量组比较,滋阴明目方高剂量组视网膜厚度增加(P<0.05),滋阴明目方中、高剂量组ATF4蛋白表达量及PERK mRNA表达量降低(P<0.01)。与VitA组相比,滋阴明目方高剂量组ATF4蛋白表达量降低(P<0.05),滋阴明目方中、高剂量组PERK mRNA表达量降低(P<0.01)。结论滋阴明目方可改善小鼠视网膜的形态,减少视网膜组织的凋亡,其分子机制可能与调控PERK-ATF4信号通路有关。 展开更多
关键词 视网膜色素变性 滋阴明目方 rd10小鼠 PERK-ATF4信号通路 凋亡 内质网应激
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Investigation of magnetization reversal and domain structures in perpendicular synthetic antiferromagnets by first-order reversal curves and magneto-optical Kerr effect
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作者 王向谦 李佳楠 +2 位作者 何开宙 谢明玲 朱旭鹏 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第11期580-584,共5页
Perpendicular synthetic-antiferromagnet(p-SAF) has broad applications in spin-transfer-torque magnetic random access memory and magnetic sensors. In this study, the p-SAF films consisting of (Co/Ni)3]/Ir(tIr)/[(Ni/Co)... Perpendicular synthetic-antiferromagnet(p-SAF) has broad applications in spin-transfer-torque magnetic random access memory and magnetic sensors. In this study, the p-SAF films consisting of (Co/Ni)3]/Ir(tIr)/[(Ni/Co)3are fabricated by magnetron sputtering technology. We study the domain structure and switching field distribution in p-SAF by changing the thickness of the infrared space layer. The strongest exchange coupling field(Hex) is observed when the thickness of Ir layer(tIr) is 0.7 nm and becoming weak according to the Ruderman–Kittel–Kasuya–Yosida-type coupling at 1.05 nm,2.1 nm, 4.55 nm, and 4.9 nm in sequence. Furthermore, the domain switching process between the upper Co/Ni stack and the bottom Co/Ni stack is different because of the antiferromagnet coupling. Compared with ferromagnet coupling films, the antiferromagnet samples possess three irreversible reversal regions in the first-order reversal curve distribution.With tIrincreasing, these irreversible reversal regions become denser and smaller. The results from this study will help us understand the details of the magnetization reversal process in the p-SAF. 展开更多
关键词 perpendicular synthetic antiferromagnet first-order reversal curves magnetization reversal pro-cess domain
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Delineating homogeneous domains of fractured rocks using topological manifolds and deep learning
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作者 Yongqiang Liu Jianping Chen +3 位作者 Fujun Zhou Jiewei Zhan Wanglai Xu Jianhua Yan 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第8期2996-3013,共18页
Determining homogeneous domains statistically is helpful for engineering geological modeling and rock mass stability evaluation.In this text,a technique that can integrate lithology,geotechnical and structural informa... Determining homogeneous domains statistically is helpful for engineering geological modeling and rock mass stability evaluation.In this text,a technique that can integrate lithology,geotechnical and structural information is proposed to delineate homogeneous domains.This technique is then applied to a high and steep slope along a road.First,geological and geotechnical domains were described based on lithology,faults,and shear zones.Next,topological manifolds were used to eliminate the incompatibility between orientations and other parameters(i.e.trace length and roughness)so that the data concerning various properties of each discontinuity can be matched and characterized in the same Euclidean space.Thus,the influence of implicit combined effect in between parameter sequences on the homogeneous domains could be considered.Deep learning technique was employed to quantify abstract features of the characterization images of discontinuity properties,and to assess the similarity of rock mass structures.The results show that the technique can effectively distinguish structural variations and outperform conventional methods.It can handle multisource engineering geological information and multiple discontinuity parameters.This technique can also minimize the interference of human factors and delineate homogeneous domains based on orientations or multi-parameter with arbitrary distributions to satisfy different engineering requirements. 展开更多
关键词 Homogeneous domain Geological domain Geotechnical domain Structural domain Topological manifold Deep learning
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Second-Order Invariant Domain Preserving ALE Approximation of Euler Equations
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作者 Jean-Luc Guermond Bojan Popov Laura Saavedra 《Communications on Applied Mathematics and Computation》 2023年第2期923-945,共23页
An invariant domain preserving arbitrary Lagrangian-Eulerian method for solving non-linear hyperbolic systems is developed.The numerical scheme is explicit in time and the approximation in space is done with continuou... An invariant domain preserving arbitrary Lagrangian-Eulerian method for solving non-linear hyperbolic systems is developed.The numerical scheme is explicit in time and the approximation in space is done with continuous finite elements.The method is made invar-iant domain preserving for the Euler equations using convex limiting and is tested on vari-ous benchmarks. 展开更多
关键词 Conservation equations Hyperbolic systems Arbitrary Lagrangian-Eulerian Moving meshes Invariant domains High-order method Convex limiting Finite element method
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ANKRD49通过增加Snail/Slug/ZEB1表达促进NCI-H1299细胞上皮-间充质转化的研究
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作者 高睿 刘超锋 +5 位作者 胡金瑞 梁刚 付荣 王维 王海龙 庞敏 《中国病理生理杂志》 CAS CSCD 北大核心 2024年第7期1190-1196,共7页
目的:研究锚蛋白重复结构域蛋白49(ANKRD49)对人肺腺癌NCI-H1299细胞上皮-间充质转化(EMT)的影响及其机制。方法:构建ANKRD49过表达的NCI-H1299肺腺癌细胞株,显微镜下观察ANKRD49过表达下细胞形态变化;采用RT-qPCR和Western blot法检测... 目的:研究锚蛋白重复结构域蛋白49(ANKRD49)对人肺腺癌NCI-H1299细胞上皮-间充质转化(EMT)的影响及其机制。方法:构建ANKRD49过表达的NCI-H1299肺腺癌细胞株,显微镜下观察ANKRD49过表达下细胞形态变化;采用RT-qPCR和Western blot法检测EMT相关指标[上皮钙黏素(E-cadherin)、转化生长因子β1(TGF-β1)、波形蛋白(vimentin)、α-平滑肌肌动蛋白(α-SMA)]及EMT相关转录因子(Snail、Slug、Twist与ZEB1)的mRNA和蛋白表达水平;采用细胞免疫荧光观察E-cadherin和vimentin在细胞中的定位和表达水平;免疫组织化学法检测ANKRD49过表达的H1299细胞及对照细胞接种裸鼠肺组织E-cadherin、α-SMA、Snail、Slug及ZEB1的表达。结果:与对照组相比,过表达ANKRD49组细胞表现出间充质细胞样形态(梭形样且紧密连接减少);RT-qPCR和Western blot结果显示ANKRD49过表达组间充质标志物vimentin和α-SMA的mRNA和蛋白质水平显著高于对照组,上皮标志物E-cadherin的mRNA和蛋白质水平低于对照组;与对照组相比,ANKRD49过表达后E-cadherin免疫荧光强度减弱,而vimentin免疫荧光强度显著增加;与对照组相比,ANKRD49过表达后显著增加Snail、Slug与ZEB1的表达;与对照组相比,ANKRD49过表达的NCI-H1299细胞接种裸鼠肺组织中E-cadherin显著减少,α-SMA、Snail、Slug及ZEB1的表达显著增加。结论:ANKRD49通过增加Snail1、Slug与ZEB1的表达来抑制E-cadherin的表达,提高vimentin和α-SMA的表达进而促进NCI-H1299细胞EMT发生。 展开更多
关键词 锚蛋白重复结构域蛋白49 肺腺癌 上皮-间充质转化
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Consistency between domain wall oscillation modes and spin wave modes in nanostrips
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作者 董新伟 吴振江 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第6期511-516,共6页
Investigations on domain wall(DW) and spin wave(SW) modes in a series of nanostrips with different widths and thicknesses have been carried out using micromagnetic simulation. The simulation results show that the freq... Investigations on domain wall(DW) and spin wave(SW) modes in a series of nanostrips with different widths and thicknesses have been carried out using micromagnetic simulation. The simulation results show that the frequencies of SW modes and the corresponding DW modes are consistent with each other if they have the same node number along the width direction. This consistency is more pronounced in wide and thin nanostrips, favoring the DW motion driven by SWs.Further analysis of the moving behavior of a DW driven by SWs is also carried out. The average DW speed can reach a larger value of ~ 140 m/s under two different SW sources. We argue that this study is very meaningful for the potential application of DW motion driven by SWs. 展开更多
关键词 micromagnetic simulation domain wall spin wave
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Mapping the antiparallel aligned domain rotation by microwave excitation
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作者 Jing Zhang Yuanzhi Cui +11 位作者 Xiaoyu Wang Chuang Wang Mengchen Liu Jie Xu Kai Li Yunhe Zhao Zhenyan Lu Lining Pan Chendong Jin Qingfang Liu Jianbo Wang Derang Cao 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第9期599-605,共7页
The evolution process of magnetic domains in response to external fields is crucial for the modern understanding and application of spintronics.In this study,we investigated the domain rotation in stripe domain films ... The evolution process of magnetic domains in response to external fields is crucial for the modern understanding and application of spintronics.In this study,we investigated the domain rotation in stripe domain films of varying thicknesses by examining their response to microwave excitation in four different orientations.The resonance spectra indicate that the rotation field of stripe domain film under an applied magnetic field approaches the field where the resonance mode of sample changes.The saturation field of the stripe domain film corresponds to the field where the resonance mode disappears when measured in the stripe direction parallel to the microwave magnetic field.The results are reproducible and consistent with micromagnetic simulations,providing additional approaches and techniques for comprehending the microscopic mechanisms of magnetic domains and characterizing their rotation. 展开更多
关键词 stripe domain magnetic film microwave excitation micromagnetic simulation
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Low-Rank Optimal Transport for Robust Domain Adaptation
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作者 Bingrong Xu Jianhua Yin +2 位作者 Cheng Lian Yixin Su Zhigang Zeng 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第7期1667-1680,共14页
When encountering the distribution shift between the source(training) and target(test) domains, domain adaptation attempts to adjust the classifiers to be capable of dealing with different domains. Previous domain ada... When encountering the distribution shift between the source(training) and target(test) domains, domain adaptation attempts to adjust the classifiers to be capable of dealing with different domains. Previous domain adaptation research has achieved a lot of success both in theory and practice under the assumption that all the examples in the source domain are welllabeled and of high quality. However, the methods consistently lose robustness in noisy settings where data from the source domain have corrupted labels or features which is common in reality. Therefore, robust domain adaptation has been introduced to deal with such problems. In this paper, we attempt to solve two interrelated problems with robust domain adaptation:distribution shift across domains and sample noises of the source domain. To disentangle these challenges, an optimal transport approach with low-rank constraints is applied to guide the domain adaptation model training process to avoid noisy information influence. For the domain shift problem, the optimal transport mechanism can learn the joint data representations between the source and target domains using a measurement of discrepancy and preserve the discriminative information. The rank constraint on the transport matrix can help recover the corrupted subspace structures and eliminate the noise to some extent when dealing with corrupted source data. The solution to this relaxed and regularized optimal transport framework is a convex optimization problem that can be solved using the Augmented Lagrange Multiplier method, whose convergence can be mathematically proved. The effectiveness of the proposed method is evaluated through extensive experiments on both synthetic and real-world datasets. 展开更多
关键词 domain adaptation low-rank constraint noise corruption optimal transport
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Multiple Matching Attenuation Based on Curvelet Domain Extended Filtering
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作者 HUA Qingfeng CHEN Zhang +6 位作者 HE Huili TAN Jun CHEN Haifeng LI Guanbao SONG Peng ZHAO Bo JIANG Xiuping 《Journal of Ocean University of China》 SCIE CAS CSCD 2024年第4期924-932,共9页
The paper develops a multiple matching attenuation method based on extended filtering in the curvelet domain,which combines the traditional Wiener filtering method with the matching attenuation method in curvelet doma... The paper develops a multiple matching attenuation method based on extended filtering in the curvelet domain,which combines the traditional Wiener filtering method with the matching attenuation method in curvelet domain.Firstly,the method uses the predicted multiple data to generate the Hilbert transform records,time derivative records and time derivative records of Hilbert transform.Then,the above records are transformed into the curvelet domain and multiple matching attenuation based on least squares extended filtering is performed.Finally,the attenuation results are transformed back into the time-space domain.Tests on the model data and field data show that the method proposed in the paper effectively suppress the multiples while preserving the primaries well.Furthermore,it has higher accuracy in eliminating multiple reflections,which is more suitable for the multiple attenuation tasks in the areas with complex structures compared to the time-space domain extended filtering method and the conventional curvelet transform method. 展开更多
关键词 multiple matching attenuation curvelet domain extended filtering
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Complementary-Label Adversarial Domain Adaptation Fault Diagnosis Network under Time-Varying Rotational Speed and Weakly-Supervised Conditions
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作者 Siyuan Liu Jinying Huang +2 位作者 Jiancheng Ma Licheng Jing Yuxuan Wang 《Computers, Materials & Continua》 SCIE EI 2024年第4期761-777,共17页
Recent research in cross-domain intelligence fault diagnosis of machinery still has some problems,such as relatively ideal speed conditions and sample conditions.In engineering practice,the rotational speed of the mac... Recent research in cross-domain intelligence fault diagnosis of machinery still has some problems,such as relatively ideal speed conditions and sample conditions.In engineering practice,the rotational speed of the machine is often transient and time-varying,which makes the sample annotation increasingly expensive.Meanwhile,the number of samples collected from different health states is often unbalanced.To deal with the above challenges,a complementary-label(CL)adversarial domain adaptation fault diagnosis network(CLADAN)is proposed under time-varying rotational speed and weakly-supervised conditions.In the weakly supervised learning condition,machine prior information is used for sample annotation via cost-friendly complementary label learning.A diagnosticmodel learning strategywith discretized category probabilities is designed to avoidmulti-peak distribution of prediction results.In adversarial training process,we developed virtual adversarial regularization(VAR)strategy,which further enhances the robustness of the model by adding adversarial perturbations in the target domain.Comparative experiments on two case studies validated the superior performance of the proposed method. 展开更多
关键词 Time-varying rotational speed weakly-supervised fault diagnosis domain adaptation
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