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基于drop-off ddPCR方法检测急性髓系白血病C-KIT基因N822位点突变及其临床应用
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作者 李婷 金晔 +7 位作者 袁倩 姚冬明 向鹤麟 肖高飞 于迪 冷加燕 林江 钱军 《江苏大学学报(医学版)》 CAS 2024年第2期151-155,160,共6页
目的:建立急性髓系白血病(acute myeloid leukemia, AML)患者C-KIT基因N822位点突变的drop-off微滴式数字PCR(droplet digital PCR,ddPCR)定量检测方法,并评价其临床应用价值。方法:针对C-KIT基因第17外显子设计一对引物及探针,优化drop... 目的:建立急性髓系白血病(acute myeloid leukemia, AML)患者C-KIT基因N822位点突变的drop-off微滴式数字PCR(droplet digital PCR,ddPCR)定量检测方法,并评价其临床应用价值。方法:针对C-KIT基因第17外显子设计一对引物及探针,优化drop-off ddPCR反应条件及体系,评价该方法的特异性、灵敏度、重复性,使用所建立的方法对140例已行Sanger测序的AML初诊患者骨髓标本进行检测,并用二代测序(next generation sequencing, NGS)验证结果;用drop-off ddPCR对3例阳性患者化疗后C-KIT突变频率进行动态监测。结果:drop-off ddPCR检测C-KIT基因N822位点突变的最适退火温度为54℃,空白检测限为1.62拷贝数/μL,最低检测下限为10.12拷贝数/μL,线性良好。140例AML初诊患者样本中Sanger测序检出2例阳性(1.4%),而ddPCR共检出突变7例(5.0%),突变频率为0.29%~7.41%;进一步应用常规NGS方法对ddPCR阳性样本进行验证,共检出阳性3例(2.1%),等位基因频率为1.26%~8.00%。动态监测3例阳性患者C-KIT突变频率,结果显示治疗达完全缓解时C-KIT突变频率明显下降甚至降低至0。结论:本研究建立了检测C-KIT基因N822位点突变的drop-off ddPCR技术,具有良好的方法学检测性能,其灵敏度高于Sanger测序和NGS,有望用于阳性患者缓解后的可检测残留疾病监测及治疗指导。 展开更多
关键词 drop-off微滴式数字PCR C-KIT基因 基因突变 微小残留病 急性髓系白血病 预后
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基于MacBERT和R-Drop的地质命名实体识别
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作者 刘昕 徐洪珍 +1 位作者 刘爱华 邓德军 《郑州大学学报(工学版)》 CAS 北大核心 2024年第3期89-95,共7页
地质命名实体识别中常用的基于BERT预训练模型的深度学习方法是基于字的方法,没有利用词信息,且神经网络中的Dropout机制会导致训练阶段和推理阶段之间存在不一致性。针对该问题,提出了一种基于MacBERT和R-Drop的地质命名实体识别模型M... 地质命名实体识别中常用的基于BERT预训练模型的深度学习方法是基于字的方法,没有利用词信息,且神经网络中的Dropout机制会导致训练阶段和推理阶段之间存在不一致性。针对该问题,提出了一种基于MacBERT和R-Drop的地质命名实体识别模型MBCR。首先,通过MacBERT学习文本特征表示,充分利用字词信息;其次,运用BiGRU编码上下文特征,有效提取完整的语义信息;最后,采用CRF获取标签间的依赖关系,生成最优标签序列。此外,在训练过程中引入R-Drop,进一步提升模型的泛化能力。结果表明:与BiLSTM-CRF、BERTBiLSTM-CRF等模型相比,所提MBCR模型在NERdata数据集上的F1值提高了2.08百分点~4.62百分点,在Boson数据集上的F1值提高了1.26百分点~17.54百分点。 展开更多
关键词 命名实体识别 地质 MacBERT BiGRU R-drop
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Buckling Properties of Water-Drop-Shaped Pressure Hulls with Various Shape Indices Under Hydrostatic External Pressure
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作者 DING Xiao-de ZHANG Jian +2 位作者 WANG Fang JIAO Hui-feng WANG Ming-lu 《China Ocean Engineering》 SCIE EI CSCD 2024年第1期1-17,共17页
The water-drop-shaped pressure hull has a good streamline,which has good application prospect in the underwater observatory.Therefore,this study conducted analytical,experimental and numerical investigation of the buc... The water-drop-shaped pressure hull has a good streamline,which has good application prospect in the underwater observatory.Therefore,this study conducted analytical,experimental and numerical investigation of the buckling properties of water-drop-shaped pressure hulls under hydrostatic pressure.A water-drop experiment was conducted to design water-drop-shaped pressure hulls with various shape indices.The critical loads for the water-drop-shaped pressure hulls were resolved by using Mushtari’s formula.Several numerical simulations including linear buckling analysis and nonlinear buckling analysis including eigenmode imperfections were performed.The results indicated that the critical loads resolved by Mushtari's formula were in good agreement with the linear buckling loads from the numerical simulations.This formula can be extended to estimate the buckling capacity of water-drop-shaped pressure hulls.In addition,three groups of pressure hulls were fabricated by using stereolithography,a rapid prototyping technique.Subsequently,three groups of the pressure hulls were subjected to ultrasonic measurements,optical scanning,hydrostatic testing and numerical analysis.The experimental results were consistent with the numerical results.The results indicate that the sharp end of the water-drop-shaped pressure hulls exhibited instability compared with the blunt end.This paper provides a new solution to the limitations of experimental studies on the water-drop-shaped pressure hulls as well as a new configuration and evaluation method for underwater observatories. 展开更多
关键词 BUCKLING pressure hull water drop underwater observatory
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A data-driven model of drop size prediction based on artificial neural networks using small-scale data sets
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作者 Bo Wang Han Zhou +3 位作者 Shan Jing Qiang Zheng Wenjie Lan Shaowei Li 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第2期71-83,共13页
An artificial neural network(ANN)method is introduced to predict drop size in two kinds of pulsed columns with small-scale data sets.After training,the deviation between calculate and experimental results are 3.8%and ... An artificial neural network(ANN)method is introduced to predict drop size in two kinds of pulsed columns with small-scale data sets.After training,the deviation between calculate and experimental results are 3.8%and 9.3%,respectively.Through ANN model,the influence of interfacial tension and pulsation intensity on the droplet diameter has been developed.Droplet size gradually increases with the increase of interfacial tension,and decreases with the increase of pulse intensity.It can be seen that the accuracy of ANN model in predicting droplet size outside the training set range is reach the same level as the accuracy of correlation obtained based on experiments within this range.For two kinds of columns,the drop size prediction deviations of ANN model are 9.6%and 18.5%and the deviations in correlations are 11%and 15%. 展开更多
关键词 Artificial neural network drop size Solvent extraction Pulsed column Two-phase flow HYDRODYNAMICS
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局部凸Hausdorff空间中的Drop定理和Drop性质 被引量:1
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作者 贺飞 刘德 +1 位作者 罗成 许成锋 《内蒙古大学学报(自然科学版)》 CAS CSCD 北大核心 2006年第3期251-257,共7页
证明了局部凸H ausdorff空间中的一个D rop定理,提出了局部凸H ausdorff空间中的-τdrop性质、拟-τdrop性质和局部D rop性质.并证明τ-序列紧凸集具有-τdrop性质,τ-可数紧凸集具有拟-τdrop性质以及局部序列紧凸集都具有局部D rop性质.
关键词 局部凸空间 drop定理 τ-drop性质 拟τ-drop性质 局部drop性质
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A-DROP评分对老年社区获得性肺炎临床结局的预测价值 被引量:5
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作者 陈冬梅 达·霹莉情 +2 位作者 杨倩 韩美荣 陈燕 《西部医学》 2023年第1期125-129,共5页
目的探讨A-DROP评分对老年社区获得性肺炎临床结局的预测价值。方法回顾性分析2019年1月~2020年12月本院呼吸与危重症医学科收治的老年社区获得性肺炎患者(CAP)临床资料,入院后24 h内完成血常规、生化等检测,并完成A-DROP、PSI、CURB-6... 目的探讨A-DROP评分对老年社区获得性肺炎临床结局的预测价值。方法回顾性分析2019年1月~2020年12月本院呼吸与危重症医学科收治的老年社区获得性肺炎患者(CAP)临床资料,入院后24 h内完成血常规、生化等检测,并完成A-DROP、PSI、CURB-65评分,根据28 d结局分为死亡及存活组,通过比较受试者工作特征曲线(ROC)分析A-DROP、PSI、CURB-65对患者28 d死亡率的预测效能。结果共纳入137例老年CAP患者,其中死亡组23例,存活组114例,A-DROP、PSI、CURB-65评分在死亡组中更高(P<0.0001);A-DROP、CURB-65、PSI危险分层预测老年CAP患者28 d死亡率的AUC值分别为0.759、0.732、0.755,A-DROP的截断值为极严重组,其敏感性为82.61%,特异性为65.79%;依据A-DROP进行危险分层,极严重组患者中位生存时间为22.638天(95%CI:20.096~25.180),极严重组患者死亡风险是中度组患者8.56倍(95%CI 3.3~22.21),是严重组患者的4.28倍(95%CI:1.32~13.9)。结论A-DROP评分系统对老年CAP患者死亡率具有一定预测价值,与PSI、CURB-65的预测效能相当。 展开更多
关键词 社区获得性肺炎 PSI CURB-65 A-drop 预后
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Drop-off微滴式数字PCR检测急性髓系白血病NRAS基因突变及其临床应用 被引量:1
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作者 向鹤麟 金晔 +6 位作者 袁倩 姚冬明 李婷 于迪 冷加燕 林江 钱军 《江苏大学学报(医学版)》 CAS 2023年第1期49-53,共5页
目的:建立检测急性髓系白血病(acute myeloid leukemia,AML)神经母细胞瘤RAS病毒癌基因同源物(NRAS)基因突变的drop-off微滴式数字PCR(droplet digital PCR,ddPCR)方法,并评价该方法的临床应用价值。方法:针对NRAS G12和G13突变位点设... 目的:建立检测急性髓系白血病(acute myeloid leukemia,AML)神经母细胞瘤RAS病毒癌基因同源物(NRAS)基因突变的drop-off微滴式数字PCR(droplet digital PCR,ddPCR)方法,并评价该方法的临床应用价值。方法:针对NRAS G12和G13突变位点设计特异性drop-off ddPCR引物和探针,建立最佳反应体系,并对该方法进行性能验证。应用该方法对140例临床样本进行初筛,其检测结果与Sanger测序进行比较,并用二代测序(next generation sequencing,NGS)进行验证。结果:建立drop-off ddPCR检测NRAS基因G12/G13突变的方法,灵敏度达0.158%,重复性、线性良好,其空白限为5.40拷贝数/μL,最低检测下限为15.84拷贝数/μL。在140例初诊AML患者中,drop-off ddPCR检出NRAS突变28例(20%),其突变负荷为0.26%~52.85%(中位2.14%);而Sanger测序仅检出7例(5%)阳性,为进一步验证,将21例Sanger测序结果阴性而drop-off ddPCR检测阳性的样本进行NRAS基因NGS,检出14例阳性,而另外7例NGS阴性的样本,其drop-off ddPCR检测突变频率为0.53%~1.50%(中位1.10%)。结论:建立了drop-off ddPCR技术检测AML患者中NRAS基因突变的方法,该方法灵敏度高,可用于对NRAS基因G12/G13突变进行定量检测,有望可用于AML患者预后判断和疾病监测。 展开更多
关键词 drop-off微滴式数字PCR NRAS基因 急性髓系白血病 基因突变 微小残留病灶 预后
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基于GRU-GCN-RDrop模型的交通速度预测 被引量:1
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作者 赵嘉雨 段亚茹 何立明 《计算机技术与发展》 2023年第4期120-125,139,共7页
准确并实时地预测交通速度是实现智能交通管控和建设智慧交通系统必不可少的一环,然而现有的预测方法无法准确地挖掘其潜在的时空相关性。为了进一步挖掘数据的时空特性以及提高预测精度,设计了基于门控循环神经网络(GRU),图卷积网络(G... 准确并实时地预测交通速度是实现智能交通管控和建设智慧交通系统必不可少的一环,然而现有的预测方法无法准确地挖掘其潜在的时空相关性。为了进一步挖掘数据的时空特性以及提高预测精度,设计了基于门控循环神经网络(GRU),图卷积网络(GCN)和正则化Dropout(R-Drop)结合的GRU-GCN-RDrop组合模型。GCN用于学习复杂的拓扑结构来捕获空间依赖性,GRU用于学习交通数据的动态变化来捕获时间依赖性。GCN和GRU相结合后使用R-Drop方法提高模型泛化能力。以SZ-taxi数据集为例进行预测分析,GRU-GCN-RDrop模型预测了未来在15分钟、30分钟、45分钟和60分钟的交通速度,并得出对应的均方根误差、平均绝对误差、精度、判定系数和解释方差。对比GCN、GRU单个模型,GRU-GCN-RDrop模型有效解决了误差的迅速累积问题。对比大多数现有基准模型,GRU-GCN-RDrop模型对于交通速度序列的特征提取及解释能力较为优秀。对比T-GCN模型和ST-AGTCN模型,GRU-GCN-RDrop模型泛化能力更强。由此说明了GRU-GCN-RDrop模型预测的交通速度时间序列具有较高的精度和稳定性。 展开更多
关键词 智慧交通系统 交通速度预测 图卷积网络 门控循环单元 正则化dropout
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Effects of endogenous dopamine induced by low concentration atropine eye drops on choroidal neovascularization in high myopia mice 被引量:2
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作者 Yan-Yan Ji Shi-Xi Zhang +1 位作者 Ye Kang Song Chen 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第7期1034-1040,共7页
AIM:To evaluate effects of endogenous dopamine induced by low concentration atropine eye drops on choroidal neovascularization(CNV)in high myopia mice.METHODS:The C57BL/6J mice were deprived of the right eye for 4wk,a... AIM:To evaluate effects of endogenous dopamine induced by low concentration atropine eye drops on choroidal neovascularization(CNV)in high myopia mice.METHODS:The C57BL/6J mice were deprived of the right eye for 4wk,and the high myopia was diagnosed by optometry,the diopter was less than-6.00 D,and CNV was induced by 532 nm laser.The changes of dopamine D1 receptor(DRD1),dopamine D2 receptor(DRD2),and vascular endothelial growth factor A(VEGFA)were detected by Western blot technology at 0.5,1,2h,and 7d after 0.01%,0.05%,and 0.1%atropine eye drops,respectively,the area of CNV was measured.RESULTS:Significant increases were observed on the expression of DRD2 in mouse high myopia model at 0.5,1,2h,7d with 0.05%and 0.1%atropine eye drops(P<0.05).Significant decreases were observed on the expression of DRD1 and VEGFA in mouse high myopia model at 0.5,1,2h,7d with 0.05%and 0.1%atropine eye drops(P<0.05).The area of CNV induced by laser in the drug-treated group was significantly smaller than that in the control group,and the higher the concentration,the more significant the inhibitory effect(P<0.05).CONCLUSION:The 0.01%,0.05%,0.1%atropine eye drops can decrease the level of VEGFA and inhibit high myopia CNV indirectly by up-regulating the level of DRD2 and down-regulating the level of DRD1,and the effect of 0.05%and 0.1%atropine eye drops is more significant. 展开更多
关键词 high myopia choroidal neovascularization low concentration atropine eye drops dopamine D1 receptor dopamine D2 receptor
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The role of cochlear implantation in alleviating Tumarkin drop attacks of Meniere's disease;a case report 被引量:1
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作者 Chiara Filippi Edoardo Covelli +2 位作者 Haitham H.Elfarargy Simonetta Monini Maurizio Barbara 《Journal of Otology》 CAS CSCD 2023年第3期168-172,共5页
Ménière’s disease(MD)patients may suffer episodes of sudden falls,named Tu markin drop attacks(DAs).This fall occurs abruptly and without warning or loss of consciousness.DAs usually aggravate the clinical ... Ménière’s disease(MD)patients may suffer episodes of sudden falls,named Tu markin drop attacks(DAs).This fall occurs abruptly and without warning or loss of consciousness.DAs usually aggravate the clinical picture of MD and are challenging to manage.The present report describes a case treated by cochlear implantation(CI)due to concomitant deafness and offers some clinical considerations for this condition.A male patient aged 48 years with a 10-year history of definite bilateral MD had profound SNHL on the right and severe SNHL on the left side.He suffered from intermittent attacks of vertigo,ear fullness,and tinnitus and,in the last year,had developed DAs and experienced 14 episodes in the previous six months.The preoperative category of acoustic performance was 3.The Dizziness Handicap Inventory(DHI)questionnaire showed a total score of 46,which indicated a moderate degree of disability.A CI was planned for the right side.The patient did not report any further DAs episode for two years since then.The postoperative category of acoustic performance became 11,and the postoperative DHI questionnaire showed a decrease in the total score(from 46 to 19),which indicated a mild disability.Unilateral CI effectively alleviated the DAs associated with bilateral MD.Our report proposes a new modality for managing vertiginous symptoms in cases of MD with hearing loss without the need for more aggressive surgical interventions with the need for clinical trials to confirm our results. 展开更多
关键词 Meniere's disease Tumarkin drop attacks Hearing loss Cochlear implant
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基于A-DROP评分的干预模式对老年社区获得性肺炎患者的康复效果影响
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作者 李静华 秦俊红 +2 位作者 赵月伟 崔英 范灵敏 《临床误诊误治》 CAS 2023年第9期63-66,共4页
目的 探讨基于A-DROP评分的干预模式对老年社区获得性肺炎(CAP)患者的康复效果。方法 选取2022年2月—2023年2月老年CAP 102例,根据干预模式的不同均分为研究组和对照组。患者全部接受基本治疗和优质护理干预,研究组选择A-DROP评分干预... 目的 探讨基于A-DROP评分的干预模式对老年社区获得性肺炎(CAP)患者的康复效果。方法 选取2022年2月—2023年2月老年CAP 102例,根据干预模式的不同均分为研究组和对照组。患者全部接受基本治疗和优质护理干预,研究组选择A-DROP评分干预治疗,对照组选择CURB-65评分干预治疗。比较2组病死率、入住重症监护病房(ICU)时间、总住院时间及医疗费用,2组咳嗽消失时间、体温恢复正常时间、肺部啰音消失时间,干预前后肺功能指标[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC]和生活质量。结果 研究组病死率低于对照组,入住ICU时间、总住院时间短于对照组,医疗费用少于对照组(P<0.05,P<0.01)。研究组咳嗽消失时间、体温恢复正常时间、肺部啰音消失时间均短于对照组(P<0.05)。研究组干预后FEV1、FVC、FEV1/FVC高于对照组(P<0.05,P<0.01)。干预后2组SF-36简明健康状况量表各项评分均升高,且研究组高于对照组(P<0.05)。结论 A-DROP评分作为CURB-65评分的改良版,更适合识别高危老年CAP住院患者及评估病情严重程度和死亡风险。 展开更多
关键词 肺炎 老年人 CURB-65评分 A-drop评分 病死率 住院时间 肺功能 生活质量
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Study of main factors influencing unsteady-state temperature drop in oil tank storage under dynamic thermal environment coupling
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作者 Wei Sun Ming-Yang Li +4 位作者 Yu-Duo Liu Qing-Lin Cheng Li-Xin Zhao Shuai Shao Zhi-Hua Wang 《Petroleum Science》 SCIE EI CAS CSCD 2023年第6期3783-3797,共15页
With the increasing oil demand, the construction of oil energy reserves in China needs to be further strengthened. However, given that there has been no research on the main influencing factors of crude oil temperatur... With the increasing oil demand, the construction of oil energy reserves in China needs to be further strengthened. However, given that there has been no research on the main influencing factors of crude oil temperature drop in storage tanks under actual dynamically changing environments, this paper considers the influence of dynamic thermal environment and internal crude oil physical properties on the fluctuating changes in crude oil temperature. A theoretical model of the unsteady-state temperature drop heat transfer process is developed from a three-dimensional perspective. According to the temperature drop variation law of crude oil storage tank under the coupling effect of various heat transfer modes such as external forced convection, thermal radiation, and internal natural convection, the external dynamic thermal environment influence zone, the internal crude oil physical property influence zone, and the intermediate transition zone of the tank are proposed. And the multiple non-linear regression method is used to quantitatively characterize the influence of external ambient temperature, solar radiation, wind speed, internal crude oil density, viscosity, and specific heat capacity on the temperature drop of crude oil in each influencing zone. The results of this paper not only quantitatively explain the main influencing factors of the oil temperature drop in the top, wall, and bottom regions of the tank, but also provide a theoretical reference for oil security reserves under a dynamic thermal environment. 展开更多
关键词 Oil temperature drop Forced convection Natural convection Dynamic thermal environment Quantitative analysis
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Pressure drop of structured packing in pilot column and comparison to common correlations
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作者 Emil Madsen Randi Neerup +3 位作者 Arne Gladis Jens K.Jørsboe Nicolas von Solms Philip L.Fosbøl 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2023年第12期281-291,共11页
Packed columns are widely used in the chemical industry such as absorption,stripping,distillation,and extraction in the production of e.g.organic chemicals,and pharmaceuticals.Pressure loss and pressure drop correlati... Packed columns are widely used in the chemical industry such as absorption,stripping,distillation,and extraction in the production of e.g.organic chemicals,and pharmaceuticals.Pressure loss and pressure drop correlations are of special interest when it comes to the hydrodynamic properties of a column.The pressure loss across the column is of interest in the design phase when the size of the blower to drive the gas stream through the column has to be decided.The loading point and flooding point are also influenced by the pressure loss and the area of operation is determined from these points.This work examines four different correlations on pressure drop.The correlations are(i)Ergun’s equation(1952),(ii)an improved version of Ergun’s equation by Stichlmair,Bravo,and Fair(1989),(iii)an equation developed by Billet and Schultes(1999),and(iv)an equation by Rocha,Bravo,and Fair(1993).The complexity of the correlations is increasing in the mentioned order,Ergun’s equation being the simplest one.This study investigates if the more complicated correlations give better predictions to pressure drop in packed columns.This is determined by comparing the correlations to experimental data for pressure drop in a packed column with 8.2 m of structured packing using water as the liquid and atmospheric air as the gas.Seven experiments were carried out for determining the pressure drop in the column with liquid flows varying from 0 to 500 kg·h^(-1).At constant liquid flow,the gas flow was varied from approximately 10 to 70 kg·h^(-1).The pressure drop across the non-wetted column was best described by the correlation by Rocha et al.while the pressure drop for liquid flows from 100 to 500 kg·h^(-1)was,in general,best described by Stichlmair’s equation.For an irrigated column,the highest deviation was a predicted pressure drop 69.6%lower than measured.The best prediction was 0.1%higher than the measured.This study shows,surprisingly,that for a system of water and atmospheric air,complicated correlations on pressure drop determination do not provide better estimates than simple equations. 展开更多
关键词 Pressure drop correlations Packed columns Structured packing Fluid dynamics
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Multi-criteria comparative analysis of the pressure drop on coal gangue fly-ash slurry at different parts along an L-shaped pipeline
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作者 Defeng Wang Dengwu Jiao +2 位作者 Zhanbo Cheng Qingwen Shi Helmut Mischo 《International Journal of Coal Science & Technology》 EI CAS CSCD 2023年第2期129-145,共17页
Disposing of coal gangue and fly-ash on the surface is a risky method with tremendous potential catastrophic consequences for the environment.Backfill mining is a promising practice for turning those hazardous wastes ... Disposing of coal gangue and fly-ash on the surface is a risky method with tremendous potential catastrophic consequences for the environment.Backfill mining is a promising practice for turning those hazardous wastes into functional backfill materi-als.Unfortunately,how to efficiently deliver the slurry to the desired places remains under-researched.To address this issue,the computational fluid dynamics software Fluent was used in the current study in addition to a laboratory rheological test to simulate the impact of various parameters on the evolution of pressure at a particular section of the pipeline.Furthermore,the response surface method was employed to investigate how the various components and their corresponding influencing weights interact to affect the pressure drop.This study demonstrates that the pressure drop of the slurry is highly influenced by slurry concentration,speed,and pipe diameter.While conveying speed is the main component in the bend section,pipe diameter takes over in the horizontal and vertical pipe sections. 展开更多
关键词 Coal gangue slurry Pressure drop Numerical simulation Response surface analysis
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In Tube Condensation:Changing the Pressure Drop into a Temperature Difference for a Wire-on-Tube Heat Exchanger
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作者 Louay Abd Al-Azez Mahdi Mohammed A.Fayad Miqdam T.Chaichan 《Fluid Dynamics & Materials Processing》 EI 2023年第9期2201-2214,共14页
A theoretical study based on the Penalty factor(PF)method by Cavallini et al.is conducted to show that the pressure drop occurring in a wire-on-tube heat exchanger can be converted into a temperature difference for tw... A theoretical study based on the Penalty factor(PF)method by Cavallini et al.is conducted to show that the pressure drop occurring in a wire-on-tube heat exchanger can be converted into a temperature difference for two types of refrigerants R-134a and R-600a typically used for charging refrigerators and freezers.The following conditions are considered:stratified or stratified-wavyflow condensation occurring inside the smooth tube of a wire-on-tube condenser with diameter 3.25,4.83,and 6.299 mm,condensation temperatures 35℃,45℃,and 54.4℃ and cover refrigerant massflow rate spanning the interval from 1 to 7 kg/hr.The results show that the PF variation is not linear with vapor quality and attains a maximum when the vapor quality is 0.2 and 0.18 for the R-134a and R-600a refrigerants,respectively.The PF increases with the refrigerant massflow rate if the inner diameter and saturation temperature constant,and it decreases on increasing the inner diameter to 6.299 mm for constant refrigerant massflow rate and saturation temperature.The PF for R-600a is higher than that for R-134a due to the lower saturation pressure in thefirst case.Furthermore,a stratifiedflow produces higher PF in comparison to the annularflow due to the effect of the surface tension. 展开更多
关键词 CONDENSATION penalty factor pressure drop temperature difference TWO-PHASE wire condenser
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Numerical simulation of drop weight impact sensitivity evaluation criteria for pressed PBXs
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作者 Hong-zheng Duan Yan-qing Wu +1 位作者 Kun Yang Feng-lei Huang 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第1期76-90,共15页
A thorough understanding of drop-weight impacted responses for polymer-bonded explosives(PBXs)is significant to evaluate their impact sensitivity.The characteristics of the drop-weight impacted pressed PBXs including ... A thorough understanding of drop-weight impacted responses for polymer-bonded explosives(PBXs)is significant to evaluate their impact sensitivity.The characteristics of the drop-weight impacted pressed PBXs including deforming,fracturing,forming a local high-temperature region and igniting,were simulated using a coupled mechanical-thermo-chemical model integrating micro-defects evolution.A novel evaluation method for impact sensitivity is established using the relation between the input kinetic energy and the output energy due to deformation,crushing energy,local hot spot energy and ignition.The effects of impact velocity on sensitivity were analyzed and the critical local ignition impact velocity is determined as 4.0-4.5 m/s.The simulated results show that shear-crack friction heating is the dominant ignition mechanism.The region along the boundary of PBXs sample is the most hazardous regions where ignition first occur.The propagation of stress wave in PBXs causes shear-crack hotspot and bulk temperature exhibiting an approximate 45°direction evolution path,which is the main reason that dominated damage-ignition region transits from the boundary to the central of sample. 展开更多
关键词 Polymer-bonded explosives(PBXs) drop weight impact Numerical simulation Sensitivity evaluation criterion Hotspot mechanism
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Influence of Wellbore Trajectory on Pressure Drop and Fluid Discharge
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作者 Ruidong Wu Guowei Wang +2 位作者 Zhixing Yang Ruiquan Liao Yang Cheng 《Fluid Dynamics & Materials Processing》 EI 2023年第8期2053-2066,共14页
An experimental analysis has been conducted to study the process of fluid accumulation for different borehole trajectories.More specifically,five heel angles have been experimentally realized to simulate the borehole ... An experimental analysis has been conducted to study the process of fluid accumulation for different borehole trajectories.More specifically,five heel angles have been experimentally realized to simulate the borehole trajectory of the sloping section of the formation.The fluid-carrying capacity,pressure drop and fluid discharge volatility have been investigated for these conditions and,accordingly,the relationship between heel angle and wellbore pressure drop fluid-carrying capacity has been determined.The results show that while the reasonable roll angle can increase the pressure loss in the wellbore,it is beneficial to drainage.In terms of pressure loss and liquid-carrying capacity,when the heeling angle is 50°,the latter is increased while the former becomes very high,which indicates that when drilling and completing wells on site,a 50°roll angle should be avoided.It is found that the main reason for the increase of the total pressure drop in the wellbore is the increase of the local pressure loss in the inclined section.From the perspective of drainage stability,when there is heeling in the inclined section of the horizontal well,the fluctuation of the wellbore drainage tends to be enhanced.Through the comparison of the Beggs-Brill(B-B)and Mukherjee-Brill liquid holdup methods,it is found that B-B method better predicts liquid holdup.A new method for calculating the pressure drop in the inclined section in the presence of lateral inclination is obtained by taking into account the pressure drop in the curved section.Through comparison with experimental data,it is found that the error is within 20%,and the prediction accuracy is high. 展开更多
关键词 Horizontal well slant section heel angle pressure drop drainage quantity
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Pump-stopping pressure drop model considering transient leak-off of fracture network
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作者 WANG Fei XU Jiaxin +1 位作者 ZHOU Tong ZHANG Shicheng 《Petroleum Exploration and Development》 SCIE 2023年第2期473-483,共11页
By introducing the coupling flow expressions of main fracture-matrix, secondary fracture-matrix and main fracture-secondary fracture into the traditional main fracture material balance equation, the “main fracture-se... By introducing the coupling flow expressions of main fracture-matrix, secondary fracture-matrix and main fracture-secondary fracture into the traditional main fracture material balance equation, the “main fracture-secondary fracture-matrix” leak-off coupling flow model is established. The pressure-dependent fracture width equation and the wellbore injection volume equation are coupled to solve the pressure-rate continuity problem. The simulation and calculation of the bottomhole pressure drop and fracture network closure after the pump stopping in slickwater volumetric fracturing treatment are realized. The research results show that the log-log curve of pump-stopping bottomhole pressure drop derivative presents five characteristic slope segments, reflecting four dominant stages, i.e. inter-fracture crossflow, fracture network leak-off, fracture network closure and residual leak-off, after pump shutdown. At the initial time of pump shutdown for volumetric fracturing treatment of horizontal well, the crossflow between main and secondary fractures is obvious, and then the leak-off becomes dominant. The leak-off of main and secondary fractures shows a non-uniform decreasing trend. Specifically, the leak-off of main fractures is slow, while that of secondary fractures is fast;the fracture network as a whole presents the leak-off law of fast first, then slow, until close to zero. The influence of fracture network conductivity on the shape of pressure decline curve is relatively weaker than that of fracture network size. The fracture network conductivity is positively correlated with leak-off volume and fracture closure. The secondary fracture size is positively correlated with leakoff volume and closure of the secondary fracture, but negatively correlated with closure of the main fracture. Field data validation proves that the proposed model and simulation results can effectively reflect the closure characteristics of the fracture network, and the interpretation results are reliable and can reflect the non-uniform stimulation performance of each fracturing stage of an actual horizontal well. 展开更多
关键词 volume fracturing stop-pumping pressure drop fracture network characteristic curve transient leak-off frac-ture closure stimulation performance
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Traffic flow of connected and automated vehicles at lane drop on two-lane highway: An optimization-based control algorithm versus a heuristic rules-based algorithm
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作者 刘华清 姜锐 +1 位作者 田钧方 朱凯旋 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第1期380-391,共12页
This paper investigates traffic flow of connected and automated vehicles at lane drop on two-lane highway. We evaluate and compare performance of an optimization-based control algorithm(OCA) with that of a heuristic r... This paper investigates traffic flow of connected and automated vehicles at lane drop on two-lane highway. We evaluate and compare performance of an optimization-based control algorithm(OCA) with that of a heuristic rules-based algorithm(HRA). In the OCA, the average speed of each vehicle is maximized. In the HRA, virtual vehicle and restriction of the command acceleration caused by the virtual vehicle are introduced. It is found that(i) capacity under the HRA(denoted as C_(H)) is smaller than capacity under the OCA;(ii) the travel delay is always smaller under the OCA, but driving is always much more comfortable under the HRA;(iii) when the inflow rate is smaller than C_(H), the HRA outperforms the OCA with respect to the fuel consumption and the monetary cost;(iv) when the inflow rate is larger than C_(H), the HRA initially performs better with respect to the fuel consumption and the monetary cost, but the OCA would become better after certain time. The spatiotemporal pattern and speed profile of traffic flow are presented, which explains the reason underlying the different performance. The study is expected to help for better understanding of the two different types of algorithm. 展开更多
关键词 traffic flow connected and automated vehicles(CAVs) lane drop optimization-based control algorithm Heuristic rules-based algorithm
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Effect of dynamic loading conditions on the dynamic performance of MP1 energy-absorbing rockbolts:Insight from laboratory drop test
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作者 Jinfu Lou Fuqiang Gao +2 位作者 Jianzhong Li Guiyang Yuan Mostafa Sharifzadeh 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2023年第2期215-231,共17页
Energy-absorbing rockbolts have been widely adopted in burst-prone excavation support, and their serviceability is closely related to the frequency and magnitude of seismic events. In this research, the splittube drop... Energy-absorbing rockbolts have been widely adopted in burst-prone excavation support, and their serviceability is closely related to the frequency and magnitude of seismic events. In this research, the splittube drop test with varying impact energy was conducted to reproduce the dynamic performance of MP1rockbolts under a wide range of seismic event magnitudes. The test results showed that the impact process could be subdivided into four distinct stages, i.e. mobilization, strain hardening, plastic flow(ductile), and rebound stage, of which strain hardening and plastic flow are the primary energy absorbing stages. As the impact energy per drop increases from 8.1 to 46.7 k J, the strain rate of the shank varies between 1.20 and 2.70 s^(-1), and the average impact load is between 240 and 270kN, which may be considered as constant. The MP1 rockbolt has a cumulative maximum energy absorption(CMEA) of 31.9–40.0 k J/m, with an average of 35.0 k J/m, and the elongation rate is 11.4%–14.7%, with an average of 12.7%, both of which are negatively correlated with the impact energy per drop. Regression analysis shows that energy absorption and shank elongation, as well as momentum input and impact duration,conform to the linear relationship. The complete dynamic capacity envelope of MP1 rockbolts is proposed, which reflects the dynamic bearing capacity, elongation, and distinct stages. This study is helpful to better understand the dynamic characteristics of energy-absorbing rockbolts and assist design engineers in robust reinforcement systems design to mitigate rockburst damage in seismically active underground excavations. 展开更多
关键词 Energy-absorbing rockbolt Dynamic performance drop test Residual elastic energy(REE) Energy absorption rate(EAR) Dynamic capacity envelope
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