Among 37 species of microbial strains, Cunninghamella echinulata AS 3.3400 were found to possess the ability to transform honokiol to （R）-magnolignan C （1） and （S）-magnolignan C （2） by regio-specific oxidation...Among 37 species of microbial strains, Cunninghamella echinulata AS 3.3400 were found to possess the ability to transform honokiol to （R）-magnolignan C （1） and （S）-magnolignan C （2） by regio-specific oxidation. Among them, 1 was a new compound. The structures of two compounds were determined by the analyses of CD, MS and NMR spectroscopic data.展开更多
Microbial transformation of pregnane-3β,16β,20-triol （1） by Cunninghamella echinulata afforded four previ- ously unreported polyhydroxylated steroids, namely pregnane-3β,14a,16β,20-tetrol （2）, pregnane-3-oxo-1...Microbial transformation of pregnane-3β,16β,20-triol （1） by Cunninghamella echinulata afforded four previ- ously unreported polyhydroxylated steroids, namely pregnane-3β,14a,16β,20-tetrol （2）, pregnane-3-oxo-14a, 16β,20-triol （3）, pregnane-3-oxo-7β,16β,20-triol （4）, and pregnane-3fl,7β,16β,20-tetrol （5）. The structures of these metabolites were established by means of spectroscopic analysis （1D and 2D NMR as well as HRESIMS analysis）.展开更多
基金The Fundamental Research Funds for the Central Universities(Grant No.2012GZF28)"985 Project"of Minzu University of China(Grant No.MUC985-9)
文摘Among 37 species of microbial strains, Cunninghamella echinulata AS 3.3400 were found to possess the ability to transform honokiol to （R）-magnolignan C （1） and （S）-magnolignan C （2） by regio-specific oxidation. Among them, 1 was a new compound. The structures of two compounds were determined by the analyses of CD, MS and NMR spectroscopic data.
基金Acknowledgement This work was supported by the National Natural Science Foundation of China （30770237） and the Pro- gram for New Century Excellent Talents in University （NCET-05-0852）.
文摘Microbial transformation of pregnane-3β,16β,20-triol （1） by Cunninghamella echinulata afforded four previ- ously unreported polyhydroxylated steroids, namely pregnane-3β,14a,16β,20-tetrol （2）, pregnane-3-oxo-14a, 16β,20-triol （3）, pregnane-3-oxo-7β,16β,20-triol （4）, and pregnane-3fl,7β,16β,20-tetrol （5）. The structures of these metabolites were established by means of spectroscopic analysis （1D and 2D NMR as well as HRESIMS analysis）.
