Radix Aconiti Lateralis Praeparata contains alkaloids,flavonoids,polysaccharides,organic acids and organic alkalis,among which diester alkaloids are important effective ingredients,which can be used for treating heart...Radix Aconiti Lateralis Praeparata contains alkaloids,flavonoids,polysaccharides,organic acids and organic alkalis,among which diester alkaloids are important effective ingredients,which can be used for treating heart failure,rheumatic heart disease,coronary heart disease,hypotension,shock and other diseases.However,it also contains the main ingredients that produce toxic effects and are highly toxic to the cardiovascular system,nervous system,digestive system,reproductive system,embryos,and livers and kidneys.In this study,we analyzed the toxicity-reducing and efficacy-enhancing effects of the compatibility of Radix Aconiti Lateralis Praeparata with with single herbs Glycyrrhiza uralensis Fisch.,Panax ginseng C.A.Meyer,Zingiber ojjicinale Rosc.and Rheum palmatum L.,aiming to provide references for further exploring the appropriate compatibility conditions of traditional Chinese medicine in the future and improving the safety of the clinical application of Radix Aconiti Lateralis Praeparata.展开更多
In 2003,two newguidelines for hyperten—sive prevention andmanagement have beenprovided by AmericanJNC7 and European So-ciety of Hypertension.They advocated that thephysician should choosedrugs following individ—uali...In 2003,two newguidelines for hyperten—sive prevention andmanagement have beenprovided by AmericanJNC7 and European So-ciety of Hypertension.They advocated that thephysician should choosedrugs following individ—ualized treatment,展开更多
Objective: To observe and assess the efficacy enhancing and toxicity attenuating effect of Nuzhen Yangyin Granule (NYG) to the anti-parkinsonism (paralysis agitans) therapy with medopa and ar-tane. Methods: Adopting t...Objective: To observe and assess the efficacy enhancing and toxicity attenuating effect of Nuzhen Yangyin Granule (NYG) to the anti-parkinsonism (paralysis agitans) therapy with medopa and ar-tane. Methods: Adopting the randomized double-blinded method, the effect of adding NYG to 30 patients with Parkinsonism in the treated group,展开更多
Drug combination based on synergistic effect is commonly used in clinical practice,especially in the application of traditional medicine.Exploring the combination mechanism could help to better utilize this synergisti...Drug combination based on synergistic effect is commonly used in clinical practice,especially in the application of traditional medicine.Exploring the combination mechanism could help to better utilize this synergistic advantage.However,current research focuses more on the efficacy enhancing of drugs,while ignoring the toxicity reducing effects.Here,we established two drug synergy patterns based on the different situations of drugs and targets,in order to better illuminate the synergistic mechanism of drugs.展开更多
The“nine cycles of steaming and shining”,“nine making”,“nine turns”and“nine cycles of calcining and quenching”methods that are recorded and used since ancient times are merely one aspect of the unique processi...The“nine cycles of steaming and shining”,“nine making”,“nine turns”and“nine cycles of calcining and quenching”methods that are recorded and used since ancient times are merely one aspect of the unique processing methods of traditional Chinese medicine.Inducing the Chinese medicine processing method“nine cycles of steaming and shining”from historical review and summarizing the practical wisdom based on the canonical aspects of traditional Chinese medicine and the experiences of ancient Chinese medicine sages to promote the new development of traditional Chinese medicine.After the long-term and multiple“nine”processing,the materials of traditional Chinese medicine exhibit significant beneficial changes in terms of taste,efficacy,and chemical composition contents,thus emphasizing that Chinese medicine processing plays a significant role in their efficacy enhancement and toxicity reduction.Heshouwu(Polygoni Multiflori Radix),Dihuang(Rehmanniae Radix),Huangjing(Rhizoma Polygonati),Dahuang(Radix et Rhizoma Rhei),and Xixiancao(Herba Siegesbeckiae)are representatives of Chinese medicinal materials prepared using the“nine-system”processing method.This review discovers the aim and the molecular mechanism of“nine”processing of the abovementioned herbs from the viewpoints of modern pharmacochemistry and pharmacology to provide a theoretical support for the“nine”processing method of traditional Chinese medicine and to promote the international market of traditional Chinese medicine.展开更多
The so-called multidrug resistance （MDR） of leukemic cells means the cross resistance of leukemic cells against multiple anti-tumor agents with different constitution and acting mechanism, which takes place simultan...The so-called multidrug resistance （MDR） of leukemic cells means the cross resistance of leukemic cells against multiple anti-tumor agents with different constitution and acting mechanism, which takes place simultaneous after resistance to a single contacted drug has been produced. Tumor cells with MDR would now show a low sensitivity to anti-tumor agents, making chemotherapy ineffective or of little effect. Moreover, MDR is one of the pathogenetic factors for inducing refractory leukemia.展开更多
Huang-Qin Decoction(HQD)is a classic prescription for diarrhea in Chinese medicine treatment.Recent studies have demonstrated that HQD and its modified formulation PHY906 could ameliorate irinotecan(CPT-11)induced gas...Huang-Qin Decoction(HQD)is a classic prescription for diarrhea in Chinese medicine treatment.Recent studies have demonstrated that HQD and its modified formulation PHY906 could ameliorate irinotecan(CPT-11)induced gastrointestinal(GI)toxicity and enhance its anticancer therapeutic efficacy.Nevertheless,which constituents in HQD are effective is still unclear so far.The study aims to screen out the key bioactive components combination from HQD that could enhance the anticancer effect of CPT-11.First,the potential bioactive constituents were obtained through system pharmacology strategy.Then the bioactivity of each constituent was investigated synthetically from the aspects of NCM460 cell migration,TNF-αrelease of THP-1-derived macrophage and MTT assay in HCT116 cell.The contribution of each constituent in HQD was evaluated using the bioactive index Ei,which taken the content and bioactivity into comprehensive consideration.And then,the most contributing constituents were selected out to form a keycomponent combination.At last,the bioefficacy of the key-component combination was validated in vitro and in vivo.As a result,a key-component combination(HB4)consisting of four compounds baicalin,baicalein,glycyrrhizic acid and wogonin was screened out.In vitro assessment indicated that HB4 could enhance the effect of CPT-11 on inhibiting cell proliferation and inducing apoptosis in HCT116.Furthermore,the in vivo study confirmed that HB4 and HQD have similar pharmacological activity and could both enhance the antitumor effect of CPT-11 in HCT116 xenograft model.Meanwhile,HB4 could also reduce the CPT-11 induced GI toxicity.展开更多
基金Guangxi Key Laboratory of Zhuang and Yao Medicines(GKJZ[2014]32)Guangxi"2011 Collaborative Innovation Center"-Collaborative Innovation Center for Zhuang and Yao Medicines(GJKY[2013]20)+2 种基金Guangxi First-class Discipline:Chinese Pharmacy(0501802815)National Natural Science Foundation of China(82060695)National Medicine Resources and Application Engineering Research Center of Guangxi Zhuang Autonomous Region(GFGGJH[2020]2605).
文摘Radix Aconiti Lateralis Praeparata contains alkaloids,flavonoids,polysaccharides,organic acids and organic alkalis,among which diester alkaloids are important effective ingredients,which can be used for treating heart failure,rheumatic heart disease,coronary heart disease,hypotension,shock and other diseases.However,it also contains the main ingredients that produce toxic effects and are highly toxic to the cardiovascular system,nervous system,digestive system,reproductive system,embryos,and livers and kidneys.In this study,we analyzed the toxicity-reducing and efficacy-enhancing effects of the compatibility of Radix Aconiti Lateralis Praeparata with with single herbs Glycyrrhiza uralensis Fisch.,Panax ginseng C.A.Meyer,Zingiber ojjicinale Rosc.and Rheum palmatum L.,aiming to provide references for further exploring the appropriate compatibility conditions of traditional Chinese medicine in the future and improving the safety of the clinical application of Radix Aconiti Lateralis Praeparata.
文摘In 2003,two newguidelines for hyperten—sive prevention andmanagement have beenprovided by AmericanJNC7 and European So-ciety of Hypertension.They advocated that thephysician should choosedrugs following individ—ualized treatment,
文摘Objective: To observe and assess the efficacy enhancing and toxicity attenuating effect of Nuzhen Yangyin Granule (NYG) to the anti-parkinsonism (paralysis agitans) therapy with medopa and ar-tane. Methods: Adopting the randomized double-blinded method, the effect of adding NYG to 30 patients with Parkinsonism in the treated group,
基金This work was supported by the National Natural Science Foundation of China(No.82003982,82274313,82204746).
文摘Drug combination based on synergistic effect is commonly used in clinical practice,especially in the application of traditional medicine.Exploring the combination mechanism could help to better utilize this synergistic advantage.However,current research focuses more on the efficacy enhancing of drugs,while ignoring the toxicity reducing effects.Here,we established two drug synergy patterns based on the different situations of drugs and targets,in order to better illuminate the synergistic mechanism of drugs.
基金This study was supported by a grant from The Key Technology Research for Traditional Chinese Medicine Modernization of Shanxi Province(Zhendong Special Project,2014ZD0302)The Key Research&Development Plan of Shanxi Province(Social Development Project,201603D3112002)Cultivate Scientific Research Excellence Programs of Higher Education Institutions in Shanxi(20190127).
文摘The“nine cycles of steaming and shining”,“nine making”,“nine turns”and“nine cycles of calcining and quenching”methods that are recorded and used since ancient times are merely one aspect of the unique processing methods of traditional Chinese medicine.Inducing the Chinese medicine processing method“nine cycles of steaming and shining”from historical review and summarizing the practical wisdom based on the canonical aspects of traditional Chinese medicine and the experiences of ancient Chinese medicine sages to promote the new development of traditional Chinese medicine.After the long-term and multiple“nine”processing,the materials of traditional Chinese medicine exhibit significant beneficial changes in terms of taste,efficacy,and chemical composition contents,thus emphasizing that Chinese medicine processing plays a significant role in their efficacy enhancement and toxicity reduction.Heshouwu(Polygoni Multiflori Radix),Dihuang(Rehmanniae Radix),Huangjing(Rhizoma Polygonati),Dahuang(Radix et Rhizoma Rhei),and Xixiancao(Herba Siegesbeckiae)are representatives of Chinese medicinal materials prepared using the“nine-system”processing method.This review discovers the aim and the molecular mechanism of“nine”processing of the abovementioned herbs from the viewpoints of modern pharmacochemistry and pharmacology to provide a theoretical support for the“nine”processing method of traditional Chinese medicine and to promote the international market of traditional Chinese medicine.
文摘The so-called multidrug resistance （MDR） of leukemic cells means the cross resistance of leukemic cells against multiple anti-tumor agents with different constitution and acting mechanism, which takes place simultaneous after resistance to a single contacted drug has been produced. Tumor cells with MDR would now show a low sensitivity to anti-tumor agents, making chemotherapy ineffective or of little effect. Moreover, MDR is one of the pathogenetic factors for inducing refractory leukemia.
基金the NSFC(Nos.81773861,81302733)Jiangsu Provincial National Science Foundation for Distinguished Young Scholars(No.BK20180027)+3 种基金National Science and Technology Major Project(2017ZX09101001)Double First-Class University projectthe Program for Jiangsu Province Innovative Research Teama project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)gsu Higher Education Institutions(PAPD)。
文摘Huang-Qin Decoction(HQD)is a classic prescription for diarrhea in Chinese medicine treatment.Recent studies have demonstrated that HQD and its modified formulation PHY906 could ameliorate irinotecan(CPT-11)induced gastrointestinal(GI)toxicity and enhance its anticancer therapeutic efficacy.Nevertheless,which constituents in HQD are effective is still unclear so far.The study aims to screen out the key bioactive components combination from HQD that could enhance the anticancer effect of CPT-11.First,the potential bioactive constituents were obtained through system pharmacology strategy.Then the bioactivity of each constituent was investigated synthetically from the aspects of NCM460 cell migration,TNF-αrelease of THP-1-derived macrophage and MTT assay in HCT116 cell.The contribution of each constituent in HQD was evaluated using the bioactive index Ei,which taken the content and bioactivity into comprehensive consideration.And then,the most contributing constituents were selected out to form a keycomponent combination.At last,the bioefficacy of the key-component combination was validated in vitro and in vivo.As a result,a key-component combination(HB4)consisting of four compounds baicalin,baicalein,glycyrrhizic acid and wogonin was screened out.In vitro assessment indicated that HB4 could enhance the effect of CPT-11 on inhibiting cell proliferation and inducing apoptosis in HCT116.Furthermore,the in vivo study confirmed that HB4 and HQD have similar pharmacological activity and could both enhance the antitumor effect of CPT-11 in HCT116 xenograft model.Meanwhile,HB4 could also reduce the CPT-11 induced GI toxicity.
