Objective:To treat patients with menstrual disorders with Wenjing Decoction and analyze its therapeutic effects.Metlods:80 patients with menstrual disorders were selected as the research subjects,and they were divided...Objective:To treat patients with menstrual disorders with Wenjing Decoction and analyze its therapeutic effects.Metlods:80 patients with menstrual disorders were selected as the research subjects,and they were divided into two groups(experimental group and control group),with each group given different treatment methods.The control group was given conventional Western medical treatment while the experimental group was given Wenjing Decoction treatment,and the effects of different treatment methods on the patients were compared.Results:The total number of effectively treated patients in the experimental group(39 cases,97.50%)was more than the that of the control group(25 cases,62.50%)。and the quality of life score of the experimental group(91.56±4.44 points)was higher that of the control group(81.72±3.19 points),and the number of menstnual recovery cycles(1.11±0.41)was less than that of the control group patients(2.42±1.25 times),P<0.05.Conclusion:The application of Wenjing Decoction for patients with menstrual disorders can significantly improve the treatment efficacy and is beneficial to improve the quality of life of the patients and shorten the number of cycles that menstruation starts to return to normal.展开更多
When the historical data of the early phase trial and the interim data of the Phase II trial are avail-able,we should use them to give a more accurate prediction in both futility and efficacy analysis.The predictive p...When the historical data of the early phase trial and the interim data of the Phase II trial are avail-able,we should use them to give a more accurate prediction in both futility and efficacy analysis.The predictive power is an important measure of the practical utility of a proposed trial,and it is better than the classical statistical power in giving a good indication of the probability that the trial will demonstrate a positive or statistically significant outcome.In addition to the four predic-tive powers with historical and interim data available in the literature and summarized in Table 1,we discover and calculate another four predictive powers also summarized in Table 1,for one-sided hypotheses.Moreover,we calculate eight predictive powers summarized in Table 2,for the reversed hypotheses.The combination of the two tables gives us a complete picture of the pre-dictive powers with historical and interim data for futility and efficacy analysis.Furthermore,the eight predictive powers with historical and interim data are utilized to guide the futility analysis in the tamoxifen example.Finally,extensive simulations have been conducted to investigate the sensitivity analysis of priors,sample sizes,interim result and interim time on different predictive powers.展开更多
文摘Objective:To treat patients with menstrual disorders with Wenjing Decoction and analyze its therapeutic effects.Metlods:80 patients with menstrual disorders were selected as the research subjects,and they were divided into two groups(experimental group and control group),with each group given different treatment methods.The control group was given conventional Western medical treatment while the experimental group was given Wenjing Decoction treatment,and the effects of different treatment methods on the patients were compared.Results:The total number of effectively treated patients in the experimental group(39 cases,97.50%)was more than the that of the control group(25 cases,62.50%)。and the quality of life score of the experimental group(91.56±4.44 points)was higher that of the control group(81.72±3.19 points),and the number of menstnual recovery cycles(1.11±0.41)was less than that of the control group patients(2.42±1.25 times),P<0.05.Conclusion:The application of Wenjing Decoction for patients with menstrual disorders can significantly improve the treatment efficacy and is beneficial to improve the quality of life of the patients and shorten the number of cycles that menstruation starts to return to normal.
基金The research was supported by National Social Science Fund of China[grant number 21XTJ001].
文摘When the historical data of the early phase trial and the interim data of the Phase II trial are avail-able,we should use them to give a more accurate prediction in both futility and efficacy analysis.The predictive power is an important measure of the practical utility of a proposed trial,and it is better than the classical statistical power in giving a good indication of the probability that the trial will demonstrate a positive or statistically significant outcome.In addition to the four predic-tive powers with historical and interim data available in the literature and summarized in Table 1,we discover and calculate another four predictive powers also summarized in Table 1,for one-sided hypotheses.Moreover,we calculate eight predictive powers summarized in Table 2,for the reversed hypotheses.The combination of the two tables gives us a complete picture of the pre-dictive powers with historical and interim data for futility and efficacy analysis.Furthermore,the eight predictive powers with historical and interim data are utilized to guide the futility analysis in the tamoxifen example.Finally,extensive simulations have been conducted to investigate the sensitivity analysis of priors,sample sizes,interim result and interim time on different predictive powers.
