Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) was applied in the detection of the end point temperature (EPT) of thermal denatured protein in fish and meat in this study. It was also used in stu...Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) was applied in the detection of the end point temperature (EPT) of thermal denatured protein in fish and meat in this study. It was also used in studying the thermal denatured temperature range of proteins in salmon and chicken meat. The results show that the temperature ranges of denatured proteins were from 65 ℃ to 75 ℃ , and these temperature ranges were influenced by the processing methods. Through SDS-PAGE, the features of repeated heating thermal denatured proteins under the same temperature and processing time were studied. The electrophoresis patterns of thermal denatured proteins determined through repeated heating at the same temperature did not exhibit any change. For the detection of cooked fish and meat samples, they were subjected to applying the SDS-PAGE method, which revealed an EPT ranging from 60 ℃ to 80 ℃ .展开更多
We calculate the quark number susceptibility （QNS） around the chiral critical end point （CEP）. The CEP is found to be located at （μc,Tc）= （80 MeV, 148 MeV） where μc and Tc are the critical chemical potential...We calculate the quark number susceptibility （QNS） around the chiral critical end point （CEP）. The CEP is found to be located at （μc,Tc）= （80 MeV, 148 MeV） where μc and Tc are the critical chemical potential and temperature, respectively. The QNS is found to have the highest and sharpest peak at the CEP. It is also found that, when the chemical potential μ is in the range of 60MeV≤ μ ≤ 110MeV, the QNS near the transition temperature is larger than the free field result, which indicates that the space-like damping mode dominates the degree of freedom of motion near the CEP.展开更多
AIM： To review the defnition and performance of the commonly used end points in trials of systemic thera-pies in metastatic castration-resistant prostate cancer patients. METHODS： A literature search was undertaken...AIM： To review the defnition and performance of the commonly used end points in trials of systemic thera-pies in metastatic castration-resistant prostate cancer patients. METHODS： A literature search was undertaken on PubMed database to identify studies meeting estab-lished criteria, with the aim of selecting randomized clinical trials and study definition and performance of their end points. The end points were grouped into three categories： overall survival （OS）, time-to-event end points, and response end points. A special analysis was performed for secondary end points of the studies which documented a beneft in OS in the experimental arm. Finally, publishes analyses for surrogacy of the in-cluded end points were also reported. RESULTS： OS, time-to-event and response end points in 31 selected trials were analyzed. OS was the pri-mary end point in 14 trials, and the secondary end point in 17. A time-to-event end point was the primaryend point in 8 studies, and the secondary end point in 22; the most reported time-to-event end points were composite end points, and the events changed among trials. A response end point was the primary end point in 9 studies, in 3 it was prostate-specifc antigen （PSA）-related, in 3 pain-related and in 3 mixed. A response end point was the secondary end point in 19 studies： PSA response and radiologic response were the most frequently used secondary end points in 19 and 11 tri-als, respectively, while pain response was used in 5 studies.CONCLUSION： A homogeneous defnition of progres-sion in future trials is mandatory. Among response end points, pain-response and PSA-response appear to be the most reliable.展开更多
We investigate the baryon number susceptibilities up to fourth order along different freeze-out lines in a holographic QCD model with a critical end point（CEP）, and we propose that the peaked baryon number susceptib...We investigate the baryon number susceptibilities up to fourth order along different freeze-out lines in a holographic QCD model with a critical end point（CEP）, and we propose that the peaked baryon number susceptibilities along the freeze-out line can be used as a clean signature to locate the CEP in the QCD phase diagram.On the temperature and baryon chemical potential plane, the cumulant ratio of the baryon number susceptibilities（up to fourth order） forms a ridge along the phase boundary, and develops a sword-shaped ＂mountain＂ standing upright around the CEP in a narrow and oblate region. The measurement of baryon number susceptibilities from heavy-ion collision experiments is along the freeze-out line. If the freeze-out line crosses the foot of the CEP mountain, then one can observe the peaked baryon number susceptibilities along the freeze-out line, and the kurtosis of the baryon number distributions has the highest magnitude. The data from the first phase of the beam energy scan program at the Relativistic Heavy Ion Collider indicates that there should be a peak of the kurtosis of the baryon number distribution at a collision energy of around 5 Ge V, which suggests that the freeze-out line crosses the foot of the CEP mountain and the summit of the CEP should be located nearby, around a collision energy of 3–7 GeV.展开更多
We investigated different entanglement properties of a holographic QCD(hQCD)model with a critical end point at the finite baryon density.Firstly,we considered the holographic entanglement entropy(HEE)of this hQCD mode...We investigated different entanglement properties of a holographic QCD(hQCD)model with a critical end point at the finite baryon density.Firstly,we considered the holographic entanglement entropy(HEE)of this hQCD model in a spherical shaped region and a strip shaped region.It was determined that the HEE of this hQCD model in both regions can reflect QCD phase transition.Moreover,although the area formulas and minimal area equations of the two regions were quite different,the HEE exhibited a similar behavior on the QCD phase diagram.Therefore,we assert that the behavior of the HEE on the QCD phase diagram is independent of the shape of the subregions.However,the HEE is not an ideal parameter for the characterization of the entanglement between different subregions of a thermal system.As such,we investigated the mutual information(MI),conditional mutual information(CMI),and the entanglement of purification(Ep)in different strip shaped regions.We determined that the three entanglement quantities exhibited some universal behavior;their values did not change significantly in the hadronic matter phase but increased rapidly with the increase in T andμin the QGP phase.Near the phase boundary,these three entanglement quantities changed smoothly in the crossover region and continuously but not smoothly at CEP;they exhibited discontinuous behavior in the first phase transition region.These properties can be used to distinguish between the different phases of strongly coupled matter.展开更多
This paper considered the optimal control problem for distributed parameter systems with mixed phase-control constraints and end-point constraints. Pontryagin's maximum principle for optimal control are derived vi...This paper considered the optimal control problem for distributed parameter systems with mixed phase-control constraints and end-point constraints. Pontryagin's maximum principle for optimal control are derived via Duboviskij-Milujin theorem.展开更多
Artificial intelligence techniques have been used to predict basic oxygen furnace(BOF) end-points. However,the main challenge is to effectively reduce the input nodes as too many input nodes in neural network increase...Artificial intelligence techniques have been used to predict basic oxygen furnace(BOF) end-points. However,the main challenge is to effectively reduce the input nodes as too many input nodes in neural network increase complexity,decrease accuracy and slow down the training speed of the network.Simply picking-up variables as input usually influence validity of model.It is quite necessary to develop an effective method to reduce the number of input nodes whereby to simplify the network and improve model performance.In this study,a variable-filtrating technique combining both metallurgical mechanism model and partial least-squares(PLS ) regression method has been proposed by taking the advantages of both of them,i.e.qualitive and quantative relationships between variables respectively.Accordingly,a fuzzy-reasoning neural network(FNN) prediction model for basic oxygen furnace(BOF) end-point carbon content based on this technique has been developed.The prediction results showed that this model can effectively improve the hit rate of end-point carbon content and increase network training speed.The successful hit rate of the model can reach up to 94.12%with about 0.02% error range.展开更多
A method of robust speech endpoint detection in airplane cockpit voice background is presented. Based on the analysis of background noise character, a complex Laplacian distribution model directly aiming at noisy spee...A method of robust speech endpoint detection in airplane cockpit voice background is presented. Based on the analysis of background noise character, a complex Laplacian distribution model directly aiming at noisy speech is established. Then the likelihood ratio test based on binary hypothesis test is carried out. The decision criterion of conventional maximum a posterior incorporating the inter-frame correlation leads to two separate thresholds. Speech endpoint detection decision is finally made depend on the previous frame and the observed spectrum, and the speech endpoint is searched based on the decision. Compared with the typical algorithms, the proposed method operates robust in the airplane cockpit voice background.展开更多
基金supported by a research project (No. 2006IK012) of the General Administration of Quality Supervision, Inspection and Quarantine of P. R. China.
文摘Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) was applied in the detection of the end point temperature (EPT) of thermal denatured protein in fish and meat in this study. It was also used in studying the thermal denatured temperature range of proteins in salmon and chicken meat. The results show that the temperature ranges of denatured proteins were from 65 ℃ to 75 ℃ , and these temperature ranges were influenced by the processing methods. Through SDS-PAGE, the features of repeated heating thermal denatured proteins under the same temperature and processing time were studied. The electrophoresis patterns of thermal denatured proteins determined through repeated heating at the same temperature did not exhibit any change. For the detection of cooked fish and meat samples, they were subjected to applying the SDS-PAGE method, which revealed an EPT ranging from 60 ℃ to 80 ℃ .
基金Supported by the National Natural Science Foundation of China under Grant Nos 11105122,11275097 and 11475085the Foundation of Graduate School of Nanjing University under Grant No 2014CL02
文摘We calculate the quark number susceptibility （QNS） around the chiral critical end point （CEP）. The CEP is found to be located at （μc,Tc）= （80 MeV, 148 MeV） where μc and Tc are the critical chemical potential and temperature, respectively. The QNS is found to have the highest and sharpest peak at the CEP. It is also found that, when the chemical potential μ is in the range of 60MeV≤ μ ≤ 110MeV, the QNS near the transition temperature is larger than the free field result, which indicates that the space-like damping mode dominates the degree of freedom of motion near the CEP.
文摘AIM： To review the defnition and performance of the commonly used end points in trials of systemic thera-pies in metastatic castration-resistant prostate cancer patients. METHODS： A literature search was undertaken on PubMed database to identify studies meeting estab-lished criteria, with the aim of selecting randomized clinical trials and study definition and performance of their end points. The end points were grouped into three categories： overall survival （OS）, time-to-event end points, and response end points. A special analysis was performed for secondary end points of the studies which documented a beneft in OS in the experimental arm. Finally, publishes analyses for surrogacy of the in-cluded end points were also reported. RESULTS： OS, time-to-event and response end points in 31 selected trials were analyzed. OS was the pri-mary end point in 14 trials, and the secondary end point in 17. A time-to-event end point was the primaryend point in 8 studies, and the secondary end point in 22; the most reported time-to-event end points were composite end points, and the events changed among trials. A response end point was the primary end point in 9 studies, in 3 it was prostate-specifc antigen （PSA）-related, in 3 pain-related and in 3 mixed. A response end point was the secondary end point in 19 studies： PSA response and radiologic response were the most frequently used secondary end points in 19 and 11 tri-als, respectively, while pain response was used in 5 studies.CONCLUSION： A homogeneous defnition of progres-sion in future trials is mandatory. Among response end points, pain-response and PSA-response appear to be the most reliable.
基金Supported by NSFC(11275213,and 11261130311)(CRC 110 by DFG and NSFC)CAS key project KJCX2-EW-N01Youth Innovation Promotion Association of CAS
文摘We investigate the baryon number susceptibilities up to fourth order along different freeze-out lines in a holographic QCD model with a critical end point（CEP）, and we propose that the peaked baryon number susceptibilities along the freeze-out line can be used as a clean signature to locate the CEP in the QCD phase diagram.On the temperature and baryon chemical potential plane, the cumulant ratio of the baryon number susceptibilities（up to fourth order） forms a ridge along the phase boundary, and develops a sword-shaped ＂mountain＂ standing upright around the CEP in a narrow and oblate region. The measurement of baryon number susceptibilities from heavy-ion collision experiments is along the freeze-out line. If the freeze-out line crosses the foot of the CEP mountain, then one can observe the peaked baryon number susceptibilities along the freeze-out line, and the kurtosis of the baryon number distributions has the highest magnitude. The data from the first phase of the beam energy scan program at the Relativistic Heavy Ion Collider indicates that there should be a peak of the kurtosis of the baryon number distribution at a collision energy of around 5 Ge V, which suggests that the freeze-out line crosses the foot of the CEP mountain and the summit of the CEP should be located nearby, around a collision energy of 3–7 GeV.
基金support by the NSFC(11947233)CPSF(2019M662507)+4 种基金the start-up funding from Zhengzhou Universitysupported in part by the NSFC(11725523,11735007,11261130311)(CRC 110 by DFG and NSFC)Chinese Academy of Sciences(XDPB09)the Fundamental Research Funds for the Central Universitiesthe start-up funding from University of Chinese Academy of Sciences。
文摘We investigated different entanglement properties of a holographic QCD(hQCD)model with a critical end point at the finite baryon density.Firstly,we considered the holographic entanglement entropy(HEE)of this hQCD model in a spherical shaped region and a strip shaped region.It was determined that the HEE of this hQCD model in both regions can reflect QCD phase transition.Moreover,although the area formulas and minimal area equations of the two regions were quite different,the HEE exhibited a similar behavior on the QCD phase diagram.Therefore,we assert that the behavior of the HEE on the QCD phase diagram is independent of the shape of the subregions.However,the HEE is not an ideal parameter for the characterization of the entanglement between different subregions of a thermal system.As such,we investigated the mutual information(MI),conditional mutual information(CMI),and the entanglement of purification(Ep)in different strip shaped regions.We determined that the three entanglement quantities exhibited some universal behavior;their values did not change significantly in the hadronic matter phase but increased rapidly with the increase in T andμin the QGP phase.Near the phase boundary,these three entanglement quantities changed smoothly in the crossover region and continuously but not smoothly at CEP;they exhibited discontinuous behavior in the first phase transition region.These properties can be used to distinguish between the different phases of strongly coupled matter.
文摘This paper considered the optimal control problem for distributed parameter systems with mixed phase-control constraints and end-point constraints. Pontryagin's maximum principle for optimal control are derived via Duboviskij-Milujin theorem.
文摘Artificial intelligence techniques have been used to predict basic oxygen furnace(BOF) end-points. However,the main challenge is to effectively reduce the input nodes as too many input nodes in neural network increase complexity,decrease accuracy and slow down the training speed of the network.Simply picking-up variables as input usually influence validity of model.It is quite necessary to develop an effective method to reduce the number of input nodes whereby to simplify the network and improve model performance.In this study,a variable-filtrating technique combining both metallurgical mechanism model and partial least-squares(PLS ) regression method has been proposed by taking the advantages of both of them,i.e.qualitive and quantative relationships between variables respectively.Accordingly,a fuzzy-reasoning neural network(FNN) prediction model for basic oxygen furnace(BOF) end-point carbon content based on this technique has been developed.The prediction results showed that this model can effectively improve the hit rate of end-point carbon content and increase network training speed.The successful hit rate of the model can reach up to 94.12%with about 0.02% error range.
文摘A method of robust speech endpoint detection in airplane cockpit voice background is presented. Based on the analysis of background noise character, a complex Laplacian distribution model directly aiming at noisy speech is established. Then the likelihood ratio test based on binary hypothesis test is carried out. The decision criterion of conventional maximum a posterior incorporating the inter-frame correlation leads to two separate thresholds. Speech endpoint detection decision is finally made depend on the previous frame and the observed spectrum, and the speech endpoint is searched based on the decision. Compared with the typical algorithms, the proposed method operates robust in the airplane cockpit voice background.
